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Krishneeta C Kashyap,1 Lisa M Nissen,1 Simon S Smith,2 James A Douglas,3 Greg J Kyle41School of Pharmacy, University of Queensland, Woolloongabba, Queensland, Australia; 2Centre for Accident Research and Road Safety, Queensland University of Technology, Kelvin Grove, Queensland, Australia; 3The Prince Charles Hospital, Chermside, Queensland, Australia; 4School of Pharmacy, University of Canberra, Bruce, Canberra, AustraliaBackground: When experiencing sleep problems for the first time, consumers may often approach community pharmacists for advice as they are easily accessible health care professionals in the community. In Australian community pharmacies there are no specific tools available for use by pharmacists to assist with the assessment and handling of consumers with sleep enquiries.Objective: To assess the feasibility of improving the detection of sleep disorders within the community through the pilot of a newly developed Community Pharmacy Sleep Assessment Tool (COP-SAT).Method: The COP-SAT was designed to incorporate elements from a number of existing, standardized, and validated clinical screening measures. The COP-SAT was trialed in four Australian community pharmacies over a 4-week period.Key findings: A total of 241 community pharmacy consumers were assessed using the COP-SAT. A total of 74 (30.7%) were assessed as being at risk of insomnia, 26 (10.7%) were at risk of daytime sleepiness, 19 (7.9%) were at risk of obstructive sleep apnea, and 121 (50.2%) were regular snorers. A total of 116 (48.1%) participants indicated that they consume caffeine before bedtime, of which 55 (47%) had associated symptoms of sleep onset insomnia. Moreover, 85 (35%) consumed alcohol before bedtime, of which 50 (58%) experienced fragmented sleep, 50 (58%) were regular snorers, and nine (10.6%) had apnea symptoms. The COP-SAT was feasible in the community pharmacy setting. The prevalence of sleep disorders in the sampled population was high, but generally consistent with previous studies on the general population.Conclusion: A large proportion of participants reported sleep disorder symptoms, and a link was found between the consumption of alcohol and caffeine substances at bedtime and associated symptoms. While larger studies are needed to assess the clinical properties of the tool, the results of this feasibility study have demonstrated that the COP-SAT may be a practical tool for the identification of patients at risk of developing sleep disorders in the community.Keywords: sleep disorder, insomnia, sleep apnea, sleep assessment, pharmacy

Purpose The role of temporary ovarian suppression with gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy as a strategy to preserve ovarian function and fertility in premenopausal women remains controversial. This systematic review and meta-analysis using individual patient-level data was conducted to better assess the efficacy and safety of this strategy in patients with early breast cancer. Methods The trials in which premenopausal women with early breast cancer were randomly assigned to receive (neo)adjuvant chemotherapy alone or with concurrent GnRHa were eligible for inclusion. Primary end points were premature ovarian insufficiency (POI) rate and post-treatment pregnancy rate. Disease-free survival and overall survival were secondary end points. Because each study represents a cluster, statistical analyses were performed using a random effects model. Results A total of 873 patients from five trials were included. POI rate was 14.1% in the GnRHa group and 30.9% in the control group (adjusted odds ratio, 0.38; 95% CI, 0.26 to 0.57; P < .001). A total of 37 (10.3%) patients had at least one post-treatment pregnancy in the GnRHa group and 20 (5.5%) in the control group (incidence rate ratio, 1.83; 95% CI, 1.06 to 3.15; P = .030). No significant differences in disease-free survival (adjusted hazard ratio, 1.01; 95% CI, 0.72 to 1.42; P = .999) and overall survival (adjusted hazard ratio, 0.67; 95% CI, 0.42 to 1.06; P = .083) were observed between groups. Conclusion Our findings provide evidence for the efficacy and safety of temporary ovarian suppression with GnRHa during chemotherapy as an available option to reduce the likelihood of chemotherapy-induced POI and potentially improve future fertility in premenopausal patients with early breast cancer.

Se analizó el contenido estomacal de una Güiña (Leopardus guigna) que fue encontrada atropellada en una zona suburbana-rural de la ciudad de Pucón. En el estómago del félido se encontró solo un individuo de Guarén (Rattus norvegicus), roedor exótico que no se había descrito previamente en la dieta de este félido. Se discute el potencial de la Güiña como controlador biológico de roedores exóticos y portadores de enfermedades.

Se describe el contenido alimenticio de una feca de Lycalopex culpaeus recolectada en diciembre de 2021 en el Parque Bosque Pehuén, localizado en la precordillera andina de la Región de La Araucanía, Chile. El análisis del contenido de la feca muestra la incidencia de dos grupos de importancia alimentaria (micromamíferos e insectos), siendo los insectos coleópteros los de mayor frecuencia, destacando entre estos el Scarabaeidae Brachysternus patagoniensis Jameson y Smith, que representa el 94,2% del total de presas consumidas. Los resultados demuestran que esta especie de escarabajo puede ser un importante alimento en la dieta de L. culpaeus cuando las poblaciones de estos insectos se encuentran en su período de mayor abundancia.

Regenerative agriculture is a potential alternative to conventional agricultural systems. It integrates the components of zero-tillage, permanent soil cover, diverse crop rotations and rotational or mob-grazing by ruminant livestock. Earthworms are beneficial soil macrofauna and function as indicators of soil health. A need exists to identify how earthworm populations are affected when all four regenerative agriculture components are implemented simultaneously. This study investigates earthworm abundance in three split-plot treatments located on adjacent land within the same farm: (1) ungrazed permanent grassland, (2) a three-year grass-clover ley within an arable zero tillage system without grazing and (3) identical to treatment 2 but with mob-grazing. Earthworms were sampled using soil pits and classified into four functional groups: epigeic (surface dwellers), endogeic (sub-surface), anecic (deep soil) and juveniles. The total earthworm count, epigeic and juvenile functional groups were significantly (p ≤ 0.05) higher in treatment (3), the arable zero tillage system with mob-grazing. Mob-grazing increases the diversity of carbon sources available to earthworms and has a positive impact on earthworm abundance and functional group diversity within the arable rotation under evaluation.

Background Dyslipidemia is an important risk factor for atherosclerotic cardiovascular disease, especially when disease presents at a young age. Despite national screening guidelines to perform a lipid profile test in children and young adults, many reproductive‐age women have not undergone lipid screening. Our objective was to assess the feasibility of lipid screening during the first trimester of pregnancy as a strategy to increase lipid screening rates among women receiving prenatal care. Methods and Results A nonfasting lipid panel was incorporated into routine prenatal care among obstetricians at a single academic clinic. Educational materials and a clinical referral pathway were developed for patients with abnormal results. Over 6 months, 445 patients had a first prenatal care visit. Of the 358 patients who completed laboratory testing, 236 (66%) patients completed lipid testing. Overall, 59 (25%) patients had abnormal results. One patient with previously undiagnosed suspected familial hypercholesterolemia was identified. Barriers to ordering lipid tests included the burden of reviewing additional laboratory results and uncertainty about patient counseling. Conclusions Implementation of nonfasting lipid screening as part of routine prenatal care during the first trimester is feasible and may play a crucial role in timely diagnosis and management of lipid disorders in women of reproductive age. Future work should focus on optimizing health system workflow to minimize burden on clinical staff and facilitate follow‐up with appropriate specialists.

Abstract We present an extension of the GM2Calc software to calculate the muon anomalous magnetic moment ( $${a_\mu ^{{\text {BSM}}}}$$ a μ BSM ) in the Two-Higgs Doublet Model. The Two-Higgs Doublet Model is one of the simplest and most popular extensions of the Standard Model. It is one of the few single field extensions that can give large contributions to $${a_\mu ^{{\text {BSM}}}}$$ a μ BSM . It is essential to include two-loop corrections to explain the long standing discrepancy between the Standard Model prediction and the experimental measurement in the Two-Higgs Doublet Model. The new version GM2Calc 2 implements the state of the art two-loop calculation for the general, flavour violating Two-Higgs Doublet Model as well as for the flavour aligned Two-Higgs Doublet Model and the type I, II, X and Y flavour conserving variants. Input parameters can be provided in either the gauge basis or the mass basis, and we provide an easy to use SLHA-like command-line interface to specify these. Using this interface users may also select between Two-Higgs Doublet Model types and choose which contributions to apply. In addition, GM2Calc 2 also provides interfaces in C++, C, Python and Mathematica, to make it easy to interface with other codes.

Abstract We present a likelihood analysis of the general two Higgs doublet model, using the most important currently measured flavour observables, in view of the anomalies in charged current tree-level and neutral current one-loop rare decays of B mesons in b → cl ν ¯ $$ \overline{\nu} $$ and b → sμ + μ − transitions, respectively. We corroborate that the model explains the latter and it is able to simultaneously fit the experimental values of the R(D) charged current ratio at 1σ, but it can not accommodate the D * charmed meson observables R(D *) and F L (D *). We find that the fitted values for the angular observables in b → sμ + μ − transitions exhibit better agreement with the general two Higgs double model in comparison to the SM. We also make predictions for future collider observables BR(t → ch), BR(h → bs), BR(h → τμ), BR(B s → τ + τ − ), BR(B + → K + τ + τ − ) and the flavour violating decays of the τ lepton, BR(τ → 3μ) and BR(τ → μγ). The model predicts values of BR(t → ch), BR(B s → τ + τ − ) and BR(B + → K + τ + τ − ) that are out of reach of future experiments, but its predictions for BR(h → bs) and BR(h → τμ) are within the future sensitivity of the HL-LHC or the ILC. We also find that the predictions for the τ → 3μ and τ → μγ decays are well within the projected limits of the Belle II experiment. Finally, using the latest measurement of the Fermilab Muon g − 2 Collaboration, we performed a simultaneous fit to ∆a μ constrained by the charged anomalies, finding solutions at the 1σ level. Once the neutral anomalies are included, however, a simultaneous explanation is unfeasible.

For patients with lupus erythematosus (LE) or dermatomyositis (DM), there is an urgent need to address a heightened risk of clinical events, chiefly heart attacks and strokes, caused by atherosclerotic cardiovascular disease (ASCVD). Patients with LE or DM frequently exhibit high levels of conventional risk factors for ASCVD events, particularly dyslipoproteinemia and hypertension; an amplified burden of atherosclerotic plaques; and increased age- and sex-adjusted rates of ASCVD events compared with the general population. The rate of ASCVD events exceeds what would be expected from conventional risk factors, suggesting that disease-specific autoimmune processes exacerbate specific, known pathogenic steps in atherosclerosis. Importantly, despite their heightened risk, patients with LE or DM are often undertreated for known causative agents and exacerbators of ASCVD. Herein, we propose an approach to assess and manage the heightened risk of ASCVD events in patients with LE or DM. Our approach is modeled in large part on established approaches to patients with diabetes mellitus or stage 3 or 4 chronic kidney disease, which are well-studied conditions that also show heightened risk for ASCVD events and have been explicitly incorporated into standard clinical guidelines for ASCVD. Based on the available evidence, we conclude that patients with LE or DM require earlier and more aggressive screening and management of ASCVD. We suggest that physicians consider implementing multipliers of conventional risk calculators to trigger earlier initiation of lifestyle modifications and medical therapies in primary prevention of ASCVD events, employ vascular imaging to quantify the burden of subclinical plaques, and treat to lower lipid targets using statins and newer therapies, such as PCSK9 inhibitors, that decrease ASCVD events in nonautoimmune cohorts. More clinical vigilance is needed regarding surveillance, prevention, risk modification, and treatment of dyslipidemias, hypertension, and smoking in patients with LE or DM. All of these goals are achievable.

Abstract Ascorbate peroxidases (APXs) are heme peroxidases involved in the control of hydrogen peroxide levels and signal transduction pathways related to development and stress responses. Here, a total of 238 APX, 30 APX-related (APX-R), and 34 APX-like (APX-L) genes were identified from 24 species from the Poaceae family. Phylogenetic analysis of APX indicated five distinct clades, equivalent to cytosolic (cAPX), peroxisomal (pAPX), mitochondrial (mitAPX), stromal (sAPX), and thylakoidal (tAPX) isoforms. Duplication events contributed to the expansion of this family and the divergence times. Different from other APX isoforms, the emergence of Poaceae mitAPXs occurred independently after eudicot and monocot divergence. Our results showed that the constitutive silencing of mitAPX genes is not viable in rice plants, suggesting that these isoforms are essential for rice regeneration or development. We also obtained rice plants silenced individually to sAPX isoforms, demonstrating that, different to plants double silenced to both sAPX and tAPX or single silenced to tAPX previously obtained, these plants do not show changes in the total APX activity and hydrogen peroxide content in the shoot. Among rice plants silenced to different isoforms, plants silenced to cAPX showed a higher decrease in total APX activity and an increase in hydrogen peroxide levels. These results suggest that the cAPXs are the main isoforms responsible for regulating hydrogen peroxide levels in the cell, whereas in the chloroplast, this role is provided mainly by the tAPX isoform. In addition to broadening our understanding of the core components of the antioxidant defense in Poaceae species, the present study also provides a platform for their functional characterization.

Las tendencias que se han desplazado en la modernidad acerca de lo que se debe en- tender política y económicamente por relaciones de convivencia democráticas, pasan por interpretar que estas relaciones de poder deben dejar de ser centralizadas en el Estado neoliberal por los grupos hegemónicos que consideran la estructura de gobierno como orden jerárquico e institucional. Entonces, las nociones de justicia, ciudadanía, participación, convivencia y diálogo, deben formar parte de un ejercicio que entre todos permita redefinir los poderes desde el espacio público y plebiscitario de la interacción social abierta. La democracia se bifurca, sus fuerzas internas son diversas en intereses e intenciones, por lo que se requiere de un Estado de derechos humanos más inclusivo para todos los ciudadanos.

Chloroplast ascorbate peroxidases exert an important role in the maintenance of hydrogen peroxide levels in chloroplasts by using ascorbate as the specific electron donor. In this work, we performed a functional study of the stromal APX in rice (OsAPX7) and demonstrated that silencing of OsAPX7 did not impact plant growth, redox state, or photosynthesis parameters. Nevertheless, when subjected to drought stress, silenced plants (APX7i) show a higher capacity to maintain stomata aperture and photosynthesis performance, resulting in a higher tolerance when compared to non-transformed plants. RNA-seq analyses indicate that the silencing of OsAPX7 did not lead to changes in the global expression of genes related to reactive oxygen species metabolism. In addition, the drought-mediated induction of several genes related to the proteasome pathway and the down-regulation of genes related to nitrogen and carotenoid metabolism was impaired in APX7i plants. During drought stress, APX7i showed an up-regulation of genes encoding flavonoid and tyrosine metabolism enzymes and a down-regulation of genes related to phytohormones signal transduction and nicotinate and nicotinamide metabolism. Our results demonstrate that OsAPX7 might be involved in signaling transduction pathways related to drought stress response, contributing to the understanding of the physiological role of chloroplast APX isoforms in rice.

Ascorbate peroxidase (APX), Monodehydroascorbate Reductase (MDAR), Dehydroascorbate Reductase (DHAR) and Glutathione Reductase (GR) enzymes participate in the ascorbate-glutathione cycle, which exerts a central role in the antioxidant metabolism in plants. Despite the importance of this antioxidant system in different signal transduction networks related to development and response to environmental stresses, the pathway has not yet been comprehensively characterized in many crop plants. Among different eudicotyledons, the Euphorbiaceae family is particularly diverse with some species highly tolerant to drought. Here the APX, MDAR, DHAR, and GR genes in Ricinus communis, Jatropha curcas, Manihot esculenta, and Hevea brasiliensis were identified and characterized. The comprehensive phylogenetic and genomic analyses allowed the classification of the genes into different classes, equivalent to cytosolic, peroxisomal, chloroplastic, and mitochondrial enzymes, and revealed the duplication events that contribute to the expansion of these families within plant genomes. Due to the high drought stress tolerance of Ricinus communis, the expression patterns of ascorbate-glutathione cycle genes in response to drought were also analyzed in leaves and roots, indicating a differential expression during the stress. Altogether, these data contributed to the characterization of the expression pattern and evolutionary analysis of these genes, filling the gap in the proposed functions of core components of the antioxidant mechanism during stress response in an economically relevant group of plants.

Objective Visually estimated coronary artery calcium (VECAC) from chest CT or attenuation correction (AC)/CT obtained during positron emission tomography (PET)–myocardial perfusion imaging (MPI) is feasible. Our aim was to determine the prognostic value of VECAC beyond conventional risk factors and PET imaging parameters, including coronary flow reserve (CFR).Methods We analysed 608 patients without known coronary artery disease who underwent PET–MPI between 2012 and 2016 and had AC/CT and/or chest CT images. We used Cox regression to estimate the association of VECAC categories (≤10, 11–400, >400 Agatston units (AU)) with the primary outcome of all-cause death, acute coronary syndrome or stroke (mean follow-up 4.3±1.8 years). C-statistics assessed the relationship between PET parameters and VECAC with the primary outcome.Results Mean age was 58±11 years, 65% were women and 67% were black. VECAC ≤10, 11–400 and >400 AU was observed in 68%, 12% and 20% of subjects, respectively. Compared with VECAC ≤10, VECAC categories 11–400 (HR 2.25, 95% CI 1.24 to 4.08) and >400 AU (HR 3.05, 95% CI 1.87 to 4.98) were associated with the primary outcome after adjusting for traditional risk factors, MPI findings and CFR. Adding VECAC to a model that included PET–MPI, CFR and clinical risk factors improved the prognostic value for the primary outcomes (c-statistic 0.71 to 0.75 with VECAC, p=0.01).Conclusions VECAC is a potent predictor of events beyond traditional risk factors and PET imaging markers, including CFR. These data further support the importance for routine VECAC implementation.

The COVID-19 crisis has revealed weaknesses and placed great stress on the agri-food system in the U.S. Many believe that it could be a catalyst event that leads to structural changes to improve the food system’s resilience. We use a sample of 220 articles published in prominent national newspapers and agricultural trade journals from March to May 2020 to explore the extent to which farmer responses to COVID-19 covered in the media represent examples of resistant, adaptive, or transformative strategies. The pandemic disrupted the U.S. food system and impacted farmers by reducing access to markets, lowering commodity prices, restricting access to farmworker labor, and shifting consumer demand. Media coverage of farmer responses to these stressors were coded into three alternative pathways: (i) reactive or buffering responses, (ii) adaptive responses; and (iii) transformative responses. Most news media coverage focused on the pandemic’s disruptive impacts on the U.S. food system, related negative impacts on farmers, and short-term responses by institutional actors, including policy-makers and food supply chain industry actors. Farmer responses to pandemic stressors were mentioned less frequently than farmer impacts and responses by institutional actors. The most common examples of farmer responses highlighted in the media reflected farmer reactive and buffering behaviors, which were mentioned significantly more frequently than adaptive or transformative responses. National newspapers were more likely to cover farmer responses and present examples of adaptive and transformative strategies compared to agricultural trade journals. Our findings suggest that news media coverage in the early months of the pandemic largely characterized the event as a rapid onset ‘natural’ disaster that created severe negative impacts. Media devoted more attention to short-term policy responses designed to mitigate these impacts than to farmer responses (in general) or to discussion of the deeper structural causes of and potential solutions to the vulnerabilities revealed by the pandemic. In this way, both national newspaper and agricultural trade journal coverage seems to promote frames that reduce the likelihood of the pandemic becoming the seed of a more resilient system.

The effect on annual konjac corm production of planting heavier corms and increasing plant density was investigated at Pukekohe Research Station, New Zealand. Corm yields were 2.2 times the planted corm weights giving a mean corm weight of 741 g harvested from large corms (325 g) and 334 g from small corms (150 g). The mean corm yield increased 1.5 t ha−1for every 10 g increase in planted corm weight in the 150–330 g range. Increasing the plant density from 33,330 to 106,670 plants ha−1had a strong linear effect on corm yield. The total yield of corms and offsets from large planted corms increased by 7.2 t ha−1for each additional plant m−2to lift yields from 34.9 t ha−1to 88.1 t ha−1. For small planted corms, total yields rose from 13.7 t ha−1to 43.9 t ha−1giving an increase of 4.1 t ha−1for each plant m−2increase. Offset production was 12% of the total corm yield grown from large corms and 20% when grown from small corms with no effect from plant spacing. [ABSTRACT FROM AUTHOR]

Widespread use of antibiotics in U.S. livestock operations has been identified as a potential contributor to the rising rates of antibiotic-resistant bacterial infections. In response, the U.S. Food and Drug Administration (FDA) issued new rules in January 2017. GFI (Guide for Industry) #213 banned use of antibiotics for growth promotion and required veterinarian permission, via a revised Veterinary Feed Directive (VFD), to deliver antibiotics through feed. Many stakeholders expressed pre-implementation concerns regarding the rules’ potential adverse effects on production and profitability. Our study employed qualitative and quantitative methods to investigate how implementation of GFI #213/VFD impacted Ohio cattle operations. We interviewed over fifty cattle farmers and eight large animal veterinarians to document changes in farm antibiotic use, management practices, and profitability. We also examined published government data for possible effects on overall meat production at the state and national levels. We found that the great majority of Ohio farmers reported little difficulty in complying with the VFD with minimal adverse impacts. Farm responses to the feed directive varied with operation size, type (beef or dairy), and whether producers had previously used fed antibiotics. The most commonly reported changes, by both producers and veterinarians, were more veterinary-client interactions, more paperwork/record-keeping, and decreased use of fed antibiotics. All veterinarians, many beef operators, but no dairy operators reported perceiving the VFD as beneficial; however, dairy operations reported less difficulty with compliance due to established working relationships with veterinarians. We found no evidence that the rules impacted the trajectory of state or national livestock output. In conclusion, GFI #213 was reported as not burdensome enough to prevent compliance, but inconvenient enough to incentivize reduced use of fed antibiotics (when previously used) without significant adverse effects, consistent with its goal of promoting judicious use of medically important antibiotics in order to preserve their effectiveness.

Large high-quality datasets of human body shape and kinematics lay the foundation for modelling and simulation approaches in computer vision, computer graphics, and biomechanics. Creating datasets that combine naturalistic recordings with high-accuracy data about ground truth body shape and pose is challenging because different motion recording systems are either optimized for one or the other. We address this issue in our dataset by using different hardware systems to record partially overlapping information and synchronized data that lend themselves to transfer learning. This multimodal dataset contains 9 hours of optical motion capture data, 17 hours of video data from 4 different points of view recorded by stationary and hand-held cameras, and 6.6 hours of inertial measurement units data recorded from 60 female and 30 male actors performing a collection of 21 everyday actions and sports movements. The processed motion capture data is also available as realistic 3D human meshes. We anticipate use of this dataset for research on human pose estimation, action recognition, motion modelling, gait analysis, and body shape reconstruction.

El presente trabajo es una lectura cultural sobre las políticas de comunicación que el Estado-nación de Velasco Alvarado (1968-1975) diseñó para difundir sus propuestas educativas y culturales. En principio, distinguimos dos conceptos claves para este artículo: medios de comunicación y publicidad. Para esta propuesta, los medios de comunicación son instrumentos que utilizan un lenguaje destinado a divulgar mensajes articulados con las propuestas educativas del régimen militar velasquista. A partir de este objetivo, la publicidad cumpliría un rol significativo: no solo utilizaría un lenguaje que condicionase las estructuras formales y de contenido de medios masivos como la prensa y la televisión, sino uno que condicionase la comunicación entre el emisor del mensaje (el Estado-nación) y el receptor del mismo (la población). En este contexto, a través del presente trabajo se sostiene que el lenguaje publicitario resultó un fenómeno comunicativo que el régimen instrumentalizó al utilizar sus recursos más usuales —imagen visual y mensaje lingüístico— para la difusión de su retórica nacionalista. Entre estos, la caricatura sería el recurso más requerido. Según lo señalado, las razones de esta instrumentalización se deben a que, si la intención del régimen militar era comunicar y educar, el lenguaje publicitario se adecuaba a estas pretensiones: es de fácil recordación y decodificación. Además, es una práctica discursiva que se incrementa en sociedades despolitizadas y prestas al consumismo como la sociedad peruana de la década de los 70.

Objective: The primary objective of this study was to explore different dimensions of Journal of the Medical Library Association (JMLA) authorship from 2006–2017. Dimensions that were evaluated using coauthorship networks and affiliation data included collaboration, geographical reach, and relationship between Medical Library Association (MLA) member and nonmember authors. A secondary objective was to analyze the practice and practical application of data science skills. Methods: A team of librarians who attended the 2017 Data Science and Visualization Institute used JMLA bibliographic metadata extracted from Scopus, together with select MLA membership data from 2006–2017. Data cleaning, anonymization, analysis, and visualization were done collaboratively by the team members to meet their learning objectives and to produce insights about the nature of collaborative authorship at JMLA. Results: Sixty-nine percent of the 1,351 JMLA authors from 2006–2017 were not MLA members. MLA members were more productive and collaborative, and tended to author articles together. The majority of the authoring institutions in JMLA are based in the United States. Global reach outside of the United States and Canada shows higher authorship in English-speaking countries (e.g., Australia, United Kingdom), as well as in Western Europe and Japan. Conclusions: MLA support of JMLA may benefit a wider network of health information specialists and medical professionals than is reflected in MLA membership. Conducting coauthorship network analyses can create opportunities for health sciences librarians to practice applying emerging data science and data visualization skills.

Resumen. Se describe el daño causado por Abyarachryson signaticolle (Blanchard, 1851), en ramas secas de “encino” (Quercus robur L., Fagaceae) y “olmo” (Ulmus sp., Ulmaceae) en el sector urbano de la ciudad de Santiago, Región Metropolitana de Santiago. Se detalla la actividad larval y la sucesión de insectos concomitantes. Se discute la importancia de estos árboles exóticos como focos de infestación. Este registro permite adicionar dos nuevos hospedantes de A. signaticolle a los conocidos previamente y se registra un parasitoide de la familia Eupelmidae (Hymenoptera), asociado a la cámara pupal de este cerambícido.

Root and rhizome production of goldenseal (Hydrastis canadensis)was measured annually from 1996 to 2002 under shade in Waikato, New Zealand. Root and rhizome production increased annually to 60–70 g dry matter (DM)/plant after 6 years, giving a root:rhizome DM yield of 5500 kg/ha. Initial growth was dominated by the roots but by the fifth and sixth year, the root:rhizome ratio remained constant at 1.2. After 6 years, approximately 84% of the root and rhizome mass was in the first 50 mm of soil, with very few roots below 100 mm. The berberine concentration in the roots and rhizomes was always above theUS Pharmacopeia's quality threshold of 2.5%. The hydrastine content was only above the US quality threshold of 2% in the rhizomes and in the roots in 1999. In the 2001 and 2002 analyses, hydrastine concentrations dropped markedly in both roots and rhizomes with the hydrastine levels in the roots being below the quality threshold. [ABSTRACT FROM PUBLISHER]

Heat acclimation (HA) is the process of intentional and consistent exercise in the heat that results in positive physiological adaptations, which can improve exercise performance both in the heat and thermoneutral conditions. Previous research has indicated the many performance benefits of HA, however, a meta-analysis examining the magnitude of different types of performance improvement is absent. Additionally, there are several methodological discrepancies in the literature that could lead to increased variability in performance improvement following HA and no previous study has examined the impact of moderators on performance improvement following HA. Therefore, the aim of this study was two-fold; (1) to perform a meta-analysis to examine the magnitude of changes in performance following HA in maximal oxygen consumption (VO2max), time to exhaustion, time trial, mean power, and peak power tests; (2) to determine the impact of moderators on results of these performance tests. Thirty-five studies met the inclusion/exclusion criteria with 23 studies that assessed VO2max (n = 204), 24 studies that assessed time to exhaustion (n = 232), 10 studies that performed time trials (n = 101), 7 studies that assessed mean power (n = 67), and 10 papers that assessed peak power (n = 88). Data are reported as Hedge's g effect size (ES), and 95% confidence intervals (95% CI). Statistical significance was set to p < 0.05, a priori. The magnitude of change following HA was analyzed, with time to exhaustion demonstrating the largest performance enhancement (ES [95% CI], 0.86 [0.71, 1.01]), followed by time trial (0.49 [0.26, 0.71]), mean power (0.37 [0.05, 0.68]), VO2max (0.30 [0.07, 0.53]), and peak power (0.29 [0.09, 0.48]) (p < 0.05). When all of the covariates were analyzed as individual models, induction method, fitness level, heat index in time to exhaustion (coefficient [95% CI]; induction method, −0.69 [−1.01, −0.37], p < 0.001; fitness level, 0.04 [0.02, 0.06], p < 0.001; heat index, 0.04 [0.02, 0.07], p < 0.0001) and induction length in mean power (coefficient [95% CI]; induction length 0.15 [0.05, 0.25], p = 0.002) significantly impacted the magnitude of change. Sport scientists and researchers can use the findings from this meta-analysis to customize HA induction. For time to exhaustion improvements, HA implementation should focus on induction method and baseline fitness, while the training and recovery balance could lead to optimal time trial performance.

In recent years, counties in the Intermountain West (Colorado, Idaho, Montana, Wyoming, and Utah) have experienced rapid population growth and housing development, and much of this growth is occurring outside of urban areas. Residential development often has negative impacts on farmlands, farm viability, and environmental services provided by working landscapes. We used county-level data to identify the association between the intensity and spatial patterns of residential settlement and trends in selected farm outcomes between 1997 and 2012 in the region. Results demonstrate that accounting for the spatial pattern or degree of fragmentation and clustering of rural and exurban residential development improves our ability to explain variation in county-level agricultural trends. We also found evidence of significant spatial dependencies among the counties in this region, which suggests that trends in one county are affected by development and agricultural activity in neighboring counties. Findings suggest that efforts to protect farming using growth management tools can work, but should focus on separation of agriculture and potentially conflicting land uses.

The procurement of high-quality lithic resources is amongst the most indicative processes of decision-making in the archaeology of early human groups peopling the Americas. Directly dated deposits from quarry workshops have been absent of the late Pleistocene record of South America. We present the results of the excavations of a high-quality translucent quartz crystal workshop that yielded radiocarbon-dated coherently layered stratigraphic deposits that shed light into the behavior of the initial stages of lithic procurement. Based on a detailed analysis of the context of the Valiente site (32° S, Chile, South America), we discuss the stages of bifacial production of point technology. The deposit produced evidence of cumulative occupations over the period between 12,630 and 11,320 calibrated years before present. This ~1,300-year span is coincidental with a major environmental step-wise drying trend as indicated by the local and regional pollen records. Furthermore, it is synchronous to the process in which natural landscapes became the earliest taskscapes in the region, thereby encompassing major cultural changes related to the organization of the land use. These results are discussed in the frame of contemporaneous archaeological data to discuss specific aspects of technology and decision-making of the earliest settlers of South America.