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116 results on '"Douglas Bauer"'

1. On the necessity of Chvátal’s Hamiltonian degree condition

Author

Douglas Bauer, Linda Lesniak, Aori Nevo, and Edward Schmeichel

Subjects
degree condition, forcibly hamiltonian degree sequence, forcibly k-connected degree sequence, Mathematics, QA1-939
Abstract

In 1972 Chvátal gave a well-known sufficient condition for a graphical sequence to be forcibly Hamiltonian, and showed that in some sense his condition is best possible. In this paper, we conjecture that with probability 1 as Chvátal’s sufficient condition is also necessary. In contrast, we essentially prove that for every , the sufficient condition of Bondy and Boesch for forcible k-connectedness is not necessary in the same way.

Published
2020
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2. Cell Cycle Arrest and Apoptosis Induction by a New 2,4-Dinitrobenzenesulfonamide Derivative In Acute Leukemia Cells

Author

Patricia Alves Almeida, Luiz Felipe Schmitz de Souza, Mariana Franzoni Maioral, Laura Otto Walter, Bruna Fischer Duarte, Íris Mattos Santos-Pirath, Douglas Bauer Speer, Larissa Sens, Tiago Tizziani, Aldo Sena de Oliveira, Ricardo José Nunes, and Maria Cláudia Santos-Silva

Subjects
Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441
Abstract

Background: Current therapies for acute leukemias (ALs) are associated with severe adverse reactions and high relapse rates, which makes the search for new antileukemic agents a necessity. Therefore, the aim of this study was to evaluate the effects of a new sulfonamide, S1, in AL cells K562 and Jurkat. Methods: The cytotoxic activity of S1 was assessed using MTT method. The involvement of apoptosis in the mechanism of cell death was assessed by flow cytometry and fluorescence microscopy. Results: Our results demonstrated that S1 induced morphological changes suggestive of apoptosis in both K562 and Jurkat cells. Additionally, S1 was not cytotoxic to normal erythrocytes and mononuclear cells and had a highly selective cytotoxicity for AL lineages. The mechanisms of cell death induced by S1 in K562 cells involves cell cycle arrest at G2/M phase and the activation of both extrinsic and intrinsic apoptosis, with an increased FasR and AIF expression and the loss of mitochondrial potential. As for Jurkat, we observed cell cycle blockade at G0/G1 phase, phosphatidylserine exposure and the involvement of intrinsic apoptosis only, with mitochondrial potential loss and a reduced expression of Survivin. Although sulfonamide S1 did not altered Bcl-2 and Bax expression in AL cell lines, it was able to activate caspase-3 in K562 cells. Conclusion: Our results suggest that sulfonamide S1 may be a promising candidate for the development of new drugs for the treatment of ALs

Published
2021
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3. Copyright

Author

Douglas Bauer

Published
2008

4. Title Page

Author

Douglas Bauer

Published
2008

5. Autumn

Author

Douglas Bauer

Published
2008

6. Prologue

Author

Douglas Bauer

Published
2008

7. Spring

Author

Douglas Bauer

Published
2008

9. Winter

Author

Douglas Bauer

Published
2008

49. The Beckoning World : A Novel

Author

Douglas Bauer and Douglas Bauer

Abstract

The Beckoning World is set in the first quarter of the twentieth century and follows Earl Dunham. His weeks are comprised of six days mining coal, followed by Sundays playing baseball. Then one day a major-league scout happens on a game, signs Earl, and he begins a life he had no idea he could even dream. But dreams sometimes suffer from a lovely abundance, and in Earl's case her name is Emily Marchand. They fall quickly and deeply in love, but with that love comes heartbreaking complications. The Beckoning World gathers a cast of characters that include Babe Ruth and Lou Gehrig; a huge-hearted Pullman steward offering aphoristic wisdom; and countless others, not least of which is the 1918 Spanish flu taking vivid spectral form. At the center is a relentless love that Earl and Emily are defenseless against, allied as they are “in this business of their hearts.”

Published
2022

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