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1. Bivalent Omicron BA.1 vaccine booster increases memory B cell breadth and neutralising antibodies against emerging SARS-CoV-2 variants

Author

Cunningham, Anthony L., Sorrell, Tania, Kelleher, Anthony, Britton, Warwick, Maclean, Mark, Lee, Sharon, Camilleri, Joanne, Douglas, Mark, Bull, Rowena, Sandgren, Kerrie, Song, Yang, Mao, Lijun, Phu, Amy, Sigmund, Allison, Beard, Sophie, Caterson, Ian, Hunt, Stephanie, Vande More, Anne Marie, Kandasamy, Rama, Kok, Jen, Byrne, Jennifer, Lloyd, Andrew, Triccas, James, Tangye, Stuart, Turville, Stuart, Brilot, Fabienne, O’Sullivan, Matthew, Steain, Megan, Baird, Sarah, Phetsouphanh, Chansavath, Zhao, Yanran, Shrestha, Lok Bahadur, Tungatt, Katie, Aggarwal, Anupriya, Stubis, Aija, Fewings, Nicole L., Fichter, Christina, Akerman, Anouschka, Rodrigo, Chaturaka, Tedla, Nicodemus, Lloyd, Andrew R., Britton, Warwick J., Caterson, Ian D., Douglas, Mark W., Rockett, Rebecca, Tangye, Stuart G., Triccas, James A., Turville, Stuart G., Sandgren, Kerrie J., and Bull, Rowena A.

Published
2024
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2. Circulating capsid-antibody-complexes (CACs) drive intrahepatic complement deposition and inform subclinical liver inflammation in chronic hepatitis B

Author

Tang, Yijie, Xu, Mingzhu, Wang, Cong, Wu, Min, Hu, Lyuyin, Li, Jin, Lu, Wei, Zheng, Ye, Zhang, Min, Jiang, Xizi, Zhu, Chuanwu, Audsley, Jennifer, Tangkijvanich, Pisit, Avihingsanon, Anchalee, Song, Shu, Liu, Shuangzhe, Lewin, Sharon R., George, Jacob, Douglas, Mark W., Ling, Yun, Yuan, Zhenghong, Zhu, Li, Zhang, Zhanqing, and Zhang, Xiaonan

Published
2024
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3. BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial

Author

Messina, Nicole L., Pittet, Laure F., McDonald, Ellie, Moore, Cecilia, Barry, Simone, Bonten, Marc, Byrne, Anthony, Campbell, John, Croda, Julio, Croda, Mariana G., Dalcolmo, Margareth, de Almeida e Val, Fernando F., de Oliveira, Roberto D., dos Santos, Glauce, Douglas, Mark W., Gardiner, Kaya, Gwee, Amanda, Jardim, Bruno A., Kollmann, Tobias, Lacerda, Marcus VG, Lucas, Michaela, Lynn, David J., Manning, Laurens, Marshall, Helen, O’Connell, Abby, Perrett, Kirsten P., Post, Jeffrey J., Prat-Aymerich, Cristina, Rocha, Jorge L., Rodriguez-Baño, Jesus, Wadia, Ushma, Warris, Adilia, Davidson, Andrew, and Curtis, Nigel

Published
2024
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4. Bacillus Calmette-Guérin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial

Author

Curtis, Nigel, Davidson, Andrew, Gardiner, Kaya, Gwee, Amanda, Jamieson, Tenaya, Messina, Nicole, Morawakage, Thilanka, Perlen, Susan, Perrett, Kirsten, Pittet, Laure, Sastry, Amber, Teo, Jia Wei, Orsini, Francesca, Lee, Katherine, Moore, Cecilia, Vidmar, Suzanna, Ali, Rashida, Dunn, Ross, Edler, Peta, Gell, Grace, Goodall, Casey, Hall, Richard, Krastev, Ann, La, Nathan, McDonald, Ellie, McPhate, Nick, Nguyen, Thao, Ren, Jack, Stevens, Luke, Alamrousi, Ahmed, Bonnici, Rhian, Dang, Thanh, Germano, Susie, Hua, Jenny, McElroy, Rebecca, Razmovska, Monica, Reddiex, Scott, Wang, Xiaofang, Anderson, Jeremy, Azzopardi, Kristy, Bennett-Wood, Vicki, Czajko, Anna, Mazarakis, Nadia, McCafferty, Conor, Oppedisano, Frances, Ortika, Belinda, Pell, Casey, Spry, Leena, Toh, Ryan, Velagapudi, Sunitha, Vlahos, Amanda, Wee-Hee, Ashleigh, Ramos, Pedro, De La Cruz, Karina, Gamage, Dinusha, Karunanayake, Anushka, Mezzetti, Isabella, Ong, Benjamin, Singh, Ronita, Sooriyarachchi, Enoshini, Nicholson, Suellen, Cain, Natalie, Brizuela, Rianne, Huang, Han, Abruzzo, Veronica, Bealing, Morgan, Bimboese, Patricia, Bowes, Kirsty, Burrell, Emma, Chan, Joyce, Cushnahan, Jac, Elborough, Hannah, Elkington, Olivia, Fahey, Kieran, Fernandez, Monique, Flynn, Catherine, Fowler, Sarah, Andrit, Marie Gentile, Gladanac, Bojana, Hammond, Catherine, Ma, Norine, Macalister, Sam, Milojevic, Emmah, Mojeed, Jesutofunmi, Nguyen, Jill, O'Donnell, Liz, Olivier, Nadia, Ooi, Isabelle, Reynolds, Stephanie, Shen, Lisa, Sherry, Barb, Spotswood, Judith, Wedderburn, Jamie, Younes, Angela, Legge, Donna, Bell, Jason, Cheah, Jo, Cobbledick, Annie, Lim, Kee, Elia, Sonja, Addlem, Lynne, Bourke, Anna, Brophy, Clare, Henare, Nadine, Jenkins, Narelle, Machingaifa, Francesca, Miller, Skye, Mitchell, Kirsten, Pitkin, Sigrid, Wall, Kate, Villanueva, Paola, Crawford, Nigel, Norton, Wendy, Tan, Niki, Chengodu, Thilakavathi, Dawson, Diane, Gordon, Victoria, Korman, Tony, O'Bryan, Jess, Agius, Sophie, Bannister, Samantha, Bucholc, Jess, Burns, Alison, Camesella, Beatriz, Carlin, John, Ciaverella, Marianna, Curtis, Maxwell, Firth, Stephanie, Guo, Christina, Hannan, Matthew, Hill, Erin, Joshi, Sri, Lieschke, Katherine, Mathers, Megan, Odoi, Sasha, Rak, Ashleigh, Richards, Chris, Steve, Leah, Stewart, Carolyn, Sudbury, Eva, Thomson, Helen, Watts, Emma, Williams, Fiona, Young, Angela, Glenn, Penny, Kaynes, Andrew, Philippart De Floy, Amandine, Buchanan, Sandy, Sondag, Thijs, Xie, Ivy, Edmund, Harriet, Byrne, Bridie, Keeble, Tom, Ngien, Belle, Noonan, Fran, Wearing-Smith, Michelle, Clarke, Alison, Davies, Pemma, Eastwood, Oliver, Ellinghaus, Alric, Ghieh, Rachid, Hilton, Zahra, Jennings, Emma, Kakkos, Athina, Liang, Iris, Nicol, Katie, O'Callaghan, Sally, Osman, Helen, Rajaram, Gowri, Ratcliffe, Sophia, Rayner, Victoria, Salmon, Ashleigh, Scheppokat, Angela, Stevens, Aimee, Street, Rebekah, Toogood, Nicholas, Wood, Nicholas, Bahaduri, Twinkle, Baulman, Therese, Byrne, Jennifer, Carter, Candace, Corbett, Mary, Dao, Aiken, Desylva, Maria, Dunn, Andrew, Gardiner, Evangeline, Joyce, Rosemary, Kandasamy, Rama, Munns, Craig, Pelayo, Lisa, Sharma, Ketaki, Sterling, Katrina, Uren, Caitlin, Colaco, Clinton, Douglas, Mark, Hamilton, Kate, Bartlett, Adam, McMullan, Brendan, Palasanthiran, Pamela, Williams, Phoebe, Beardsley, Justin, Bergant, Nikki, Lagunday, Renier, Overton, Kristen, Post, Jeffrey, Al-Hindawi, Yasmeen, Barney, Sarah, Byrne, Anthony, Mead, Lee, Plit, Marshall, Lynn, David, Benson, Saoirse, Blake, Stephen, Botten, Rochelle, Chern, Tee Yee, Eden, Georgina, Griffith, Liddy, James, Jane, Lynn, Miriam, Markow, Angela, Sacca, Domenic, Stevens, Natalie, Wesselingh, Steve, Doran, Catriona, Barry, Simone, Sawka, Alice, Evans, Sue, Goodchild, Louise, Heath, Christine, Krieg, Meredith, Marshall, Helen, McMillan, Mark, Walker, Mary, Richmond, Peter, Amenyogbe, Nelly, Anthony, Christina, Arnold, Annabelle, Arrowsmith, Beth, Ben-Othman, Rym, Clark, Sharon, Dunnill, Jemma, Eiffler, Nat, Ewe, Krist, Finucane, Carolyn, Flynn, Lorraine, Gibson, Camille, Hartnell, Lucy, Hollams, Elysia, Hutton, Heidi, Jarvis, Lance, Jones, Jane, Jones, Jan, Jones, Karen, Kent, Jennifer, Kollmann, Tobias, Lalich, Debbie, Lee, Wenna, Lim, Rachel, McAlister, Sonia, McDonald, Fiona, Meehan, Andrea, Minhaj, Asma, Montgomery, Lisa, O'Donnell, Melissa, Ong, Jaslyn, Ong, Joanne, Parkin, Kimberley, Perez, Glady, Power, Catherine, Rezazadeh, Shadie, Richmond, Holly, Rogers, Sally, Schultz, Nikki, Shave, Margaret, Skut, Patrycja, Stiglmayer, Lisa, Truelove, Alexandra, Wadia, Ushma, Wallace, Rachael, Waring, Justin, England, Michelle, Latkovic, Erin, Manning, Laurens, Herrmann, Susan, Lucas, Michaela, Lacerda, Marcus, Andrade, Paulo Henrique, Barbosa, Fabiane Bianca, Barros, Dayanne, Brasil, Larissa, Capella, Ana Greyce, Castro, Ramon, Costa, Erlane, de Souza, Dilcimar, Dias, Maianne, Dias, José, Ferreira, Klenilson, Figueiredo, Paula, Freitas, Thamires, Furtado, Ana Carolina, Gama, Larissa, Godinho, Vanessa, Gouy, Cintia, Hinojosa, Daniele, Jardim, Bruno, Jardim, Tyane, Junior, Joel, Lima, Augustto, Maia, Bernardo, Marins, Adriana, Mazurega, Kelry, Medeiros, Tercilene, Melo, Rosangela, Moraes, Marinete, Nascimento, Elizandra, Neves, Juliana, Oliveira, Maria Gabriela, Oliveira, Thais, Oliveira, Ingrid, Otsuka, Arthur, Paes, Rayssa, Pereira, Handerson, Pereira, Gabrielle, Prado, Christiane, Queiroz, Evelyn, Rodrigues, Laleyska, Rodrigues, Bebeto, Sampaio, Vanderson, Santos, Anna Gabriela, Santos, Daniel, Santos, Tilza, Santos, Evelyn, Sartim, Ariandra, Silva, Ana Beatriz, Silva, Juliana, Silva, Emanuelle, Simão, Mariana, Soares, Caroline, Sousa, Antonny, Trindade, Alexandre, Val, Fernando, Vasconcelos, Adria, Vasconcelos, Heline, Croda, Julio, Abreu, Carolinne, Almeida, Katya Martinez, Bitencourt de Andrade, Camila, Campos Angelo, Jhenyfer Thalyta, Gonçalvez de Araújo Arcanjo, Ghislaine, Silva Menezes Arruda, Bianca Maria, Ayala, Wellyngthon Espindola, Refosco Barbosa, Adelita Agripina, Vieira Batista, Felipe Zampieri, de Morais Batista, Fabiani, de Jesus Costa, Miriam, Croda, Mariana Garcia, Alves da Cruz, Lais, Pereira Diogo, Roberta Carolina, Dutra Escobar, Rodrigo Cezar, Fernandes, Iara Rodrigues, Figueiredo, Leticia Ramires, Cavalcanti Gonçalves, Leandro Galdino, Lahdo, Sarita, Lencina, Joyce dos Santos, Teodoro de Lima, Guilherme, Matos, Larissa Santos, Leopoldina Meireles, Bruna Tayara, Moreira, Debora Quadros, Silva Muranaka, Lilian Batista, de Oliveira, Adriely, Warszawski de Oliveira, Karla Regina, Vieira de Oliveira, Matheus, Dias de Oliveira, Roberto, Souza de Almeida dos Reis Pereira, Andrea Antonia, Puga, Marco, Ramos, Caroliny Veron, Souza da Rosa, Thaynara Haynara, Lopes dos Santos, Karla, Ribeiro dos Santos, Claudinalva, Leopoldina dos Santos, Dyenyffer Stéffany, Santos, Karina Marques, Pereira da Silva, Paulo César, Rocha da Silva, Paulo Victor, Silva, Débora dos Santos, Vieira da Silva, Patricia, Freitas da Rosa Soares, Bruno, Sperotto, Mariana Gazzoni, Tadokoro, Mariana Mayumi, Tsuha, Daniel, Ramos Vieira, Hugo Miguel, Pretti Dalcolmo, Margareth Maria, Lopes Alves da Paixão, Cíntia Maria, Corrêa E Castro, Gabriela, Collopy, Simone Silva, da Costa Silva, Renato, Almeida da Silveira, Samyra, Da-Cruz, Alda Maria, Maria da Silva Passos de Carvalho, Alessandra, de Cássia Batista, Rita, Silva De Freitas, Maria Luciana, Gerhardt de Oliveira Ferreira, Aline, Conceição de Souza, Ana Paula, Doblas, Paola Cerbino, Alcoforado da Silva dos Santos, Ayla, Cristine de Moraes dos Santos, Vanessa, Alves dos Santos Gomes, Dayane, Fortunato, Anderson Lage, Gomes-Silva, Adriano, Gonçalves, Monique Pinto, Garcia Meireless Junior, Paulo Leandro, Martins da Costa Carvalho, Estela, Motta, Fernando do Couto, Olivo de Mendonça, Ligia Maria, Pandine, Girlene dos Santos, Plácido Pereira, Rosa Maria, Maia, Ivan Ramos, Luiz da Rocha, Jorge, Paiva Romano, João Victor, Santos, Glauce dos, Fernandes da Silva, Erica, Mendonça Teixeira de Siqueira, Marilda Agudo, Prudêncio Soares, Ágatha Cristinne, Bonten, Marc, Arroyo, Sandra Franch, Besten, Henny Ophorst-den, Boon, Anna, Brakke, Karin M., Janssen, Axel, Koopmans, Marijke A.H., Lemmens, Toos, Leurink, Titia, Prat-Aymerich, Cristina, Septer-Bijleveld, Engelien, Stadhouders, Kimberly, Troeman, Darren, van der Waal, Marije, van Opdorp, Marjoleine, van Sluis, Nicolette, Wolters, Beatrijs, Kluytmans, Jan, Romme, Jannie, van den Bijllaardt, Wouter, van Mook, Linda, Rijen, M.M.L (Miranda) van, Filius, P.M.G., Gisolf, Jet, Greven, Frances, Huijbens, Danique, Hassing, Robert Jan, Pon, R.C., Preijers, Lieke, van Leusen, J.H., Verheij, Harald, Boersma, Wim, Brans, Evelien, Kloeg, Paul, Molenaar-Groot, Kitty, Nguyen, Nhat Khanh, Paternotte, Nienke, Rol, Anke, Stooper, Lida, Dijkstra, Helga, Eggenhuizen, Esther, Huijs, Lucas, Moorlag, Simone, Netea, Mihai, Pranger, Eva, Taks, Esther, Oever, Jaap ten, Heine, Rob ter, Blauwendraat, Kitty, Meek, Bob, Erkaya, Isil, Harbech, Houda, Roescher, Nienke, Peeters, Rifka, Riele, Menno te, Zhou, Carmen, Calbo, Esther, Marti, Cristina Badia, Palomares, Emma Triviño, Porcuna, Tomás Perez, Barriocanal, Anabel, Barriocanal, Ana Maria, Casas, Irma, Dominguez, Jose, Esteve, Maria, Lacoma, Alicia, Latorre, Irene, Molina, Gemma, Molina, Barbara, Rosell, Antoni, Vidal, Sandra, Barrera, Lydia, Bustos, Natalia, Calderón, Ines Portillo, Campos, David Gutierrez, Carretero, Jose Manuel, Castellano, Angel Dominguez, Compagnone, Renato, Ramirez de Arellano, Encarnacion, Serna, Almudena de la, Dolores del Toro Lopez, Maria, Clement Espindola, Marie-Alix, Martin Gutierrez, Ana Belen, Hernandez, Alvaro Pascual, Jiménez, Virginia Palomo, Moreno, Elisa, Navarrete, Nicolas, Paño, Teresa Rodriguez, Rodríguez-Baño, Jesús, Tristán, Enriqueta, Rios Villegas, Maria Jose, Garces, Atsegiñe Canga, Amo, Erika Castro, Guerrero, Raquel Coya, Goikoetxea, Josune, Jorge, Leticia, Perez, Cristina, Fariñas Álvarez, María Carmen, Cuadra, Manuel Gutierrez, Arnaiz de las Revillas Almajano, Francisco, Garcia, Pilar Bohedo, Poderos, Teresa Giménez, Rico, Claudia González, Sanchez, Blanca, Valero, Olga, Vega, Noelia, Campbell, John, Barnes, Anna, Catterick, Helen, Cranston, Tim, Dawe, Phoebe, Fletcher, Emily, Fouracre, Liam, Gifford, Alison, Kirkwood, John, Martin, Christopher, McAnew, Amy, Mitchell, Marcus, Newman, Georgina, O'Connell, Abby, Onysk, Jakob, Quinn, Lynne, Rhodes, Shelley, Stone, Samuel, Symons, Lorrie, Tripp, Harry, Warris, Adilia, Watkins, Darcy, Whale, Bethany, Harding, Alex, Lockhart, Gemma, Sidaway-Lee, Kate, Hilton, Sam, Manton, Sarah, Webber-Rookes, Daniel, Winder, Rachel, Moore, James, Bateman, Freya, Gibbons, Michael, Knight, Bridget, Moss, Julie, Statton, Sarah, Studham, Josephine, Hall, Lydia, Moyle, Will, Venton, Tamsin, Pittet, Laure F., Moore, Cecilia L., Dalcolmo, Margareth, Douglas, Mark W., Lacerda, Marcus V.G., Lynn, David J., de Oliveira, Roberto D., Perrett, Kirsten P., Richmond, Peter C., Rocha, Jorge L., Rodriguez-Baño, Jesus, Wood, Nicholas J., and Messina, Nicole L.

Published
2023
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6. Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals

Author

Martinello, Marianne, Matthews, Gail, Fernando, Fay Fabián, Esteban, Juan I., Müllhaupt, Beat, Wiesch, Julian Schulze zur, Buggisch, Peter, Neumann-Haefelin, Christoph, Berg, Thomas, Berg, Christoph P., Schattenberg, Jörn M., Moreno, Christophe, Stauber, Rudolf, Lloyd, Andrew, Dore, Gregory, Applegate, Tanya, Ignacio, Juan, Garcia-Cehic, Damir, Gregori, Josep, Rodriguez-Frias, Francisco, Rando, Ariadna, Gozlan, Yael, Angelico, Mario, Andreoni, Massimo, Babudieri, Sergio, Bertoli, Ada, Cento, Valeria, Coppola, Nicola, Craxì, Antonio, Paolucci, Stefania, Parruti, Giustino, Pasquazzi, Caterina, Perno, Carlo Federico, Teti, Elisabetta, Vironet, C., Lannergård, Anders, Duberg, Ann-Sofi, Aleman, Soo, Gutteberg, Tore, Soulier, Alexandre, Gourgeon, Aurélie, Chevaliez, Stephane, Pol, Stanislas, Carrat, Fabrice, Salmon, Dominique, Kaiser, Rolf, Knopes, Elena, Gomes, Perpetua, de Kneght, Rob, Rijnders, Bart, Poljak, Mario, Lunar, Maja, Usubillaga, Rafael, Seguin_Devaux, Carole, Tay, Enoch, Wilson, Caroline, Wang, Dao Sen, George, Jacob, Kok, Jen, Pérez, Ana Belén, Chueca, Natalia, García-Deltoro, Miguel, Martínez-Sapiña, Ana María, Lara-Pérez, María Magdalena, García-Bujalance, Silvia, Aldámiz-Echevarría, Teresa, Vera-Méndez, Francisco Jesús, Pineda, Juan Antonio, Casado, Marta, Pascasio, Juan Manuel, Salmerón, Javier, Alados-Arboledas, Juan Carlos, Poyato, Antonio, Téllez, Francisco, Rivero-Juárez, Antonio, Merino, Dolores, Vivancos-Gallego, María Jesús, Rosales-Zábal, José Miguel, Ocete, María Dolores, Simón, Miguel Ángel, Rincón, Pilar, Reus, Sergi, De la Iglesia, Alberto, García-Arata, Isabel, Jiménez, Miguel, Jiménez, Fernando, Hernández-Quero, José, Galera, Carlos, Balghata, Mohamed Omar, Primo, Joaquín, Masiá, Mar, Espinosa, Nuria, Delgado, Marcial, von-Wichmann, Miguel Ángel, Collado, Antonio, Santos, Jesús, Mínguez, Carlos, Díaz-Flores, Felícitas, Fernández, Elisa, Bernal, Enrique, De Juan, José, Antón, José Joaquín, Vélez, Mónica, Aguilera, Antonio, Navarro, Daniel, Arenas, Juan Ignacio, Fernández, Clotilde, Espinosa, María Dolores, Ríos, María José, Alonso, Roberto, Hidalgo, Carmen, Hernández, Rosario, Téllez, María Jesús, Rodríguez, Francisco Javier, Antequera, Pedro, Delgado, Cristina, Martín, Patricia, Crespo, Javier, Becerril, Berta, Pérez, Oscar, García-Herola, Antonio, Montero, José, Freyre, Carolina, Grau, Concepción, Cabezas, Joaquin, Jimenez, Miguel, Rodriguez, Manuel Alberto Macias, Quilez, Cristina, Pardo, Maria Rodriguez, Muñoz-Medina, Leopoldo, Figueruela, Blanca, Howe, Anita Y.M., Rodrigo, Chaturaka, Cunningham, Evan B., Douglas, Mark W., Dietz, Julia, Grebely, Jason, Popping, Stephanie, Sfalcin, Javier Alejandro, Parczewski, Milosz, Sarrazin, Christoph, de Salazar, Adolfo, Fuentes, Ana, Sayan, Murat, Quer, Josep, Kjellin, Midori, Kileng, Hege, Mor, Orna, Lennerstrand, Johan, Fourati, Slim, Di Maio, Velia Chiara, Chulanov, Vladimir, Pawlotsky, Jean-Michel, Harrigan, P. Richard, Ceccherini-Silberstein, Francesca, and Garcia, Federico

Published
2022
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7. Hepatitis B Virus and Hepatitis C Virus Affect Mitochondrial Function Through Different Metabolic Pathways, Explaining Virus-Specific Clinical Features of Chronic Hepatitis.

Author

Selvamani, Sakthi Priya, Khan, Anis, Tay, Enoch S E, Garvey, Matthew, Ajoyan, Harout, Diefenbach, Eve, Gloss, Brian S, Tu, Thomas, George, Jacob, and Douglas, Mark W

Subjects
PYRUVATE dehydrogenase kinase, HEPATITIS C virus, HEPATITIS B virus, FATTY liver, CHRONIC active hepatitis, LACTATES
Abstract

Background Hepatitis C virus (HCV) and hepatitis B virus (HBV) cause chronic hepatitis with important clinical differences. HCV causes hepatic steatosis and insulin resistance, while HBV confers increased risk of liver cancer. We hypothesized these differences may be due to virus-specific effects on mitochondrial function. Methods Seahorse technology was used to investigate effects of virus infection on mitochondrial function. Cell-based assays were used to measure mitochondrial membrane potential and quantify pyruvate and lactate. Mass spectrometry was performed on mitochondria isolated from HBV-expressing, HCV-infected, and control cells cultured with isotope-labelled amino acids, to identify proteins with different abundance. Altered expression of key mitochondrial proteins was confirmed by real-time polymerase chain reaction (PCR) and western blot. Results Reduced mitochondrial function and ATP production were observed with HCV infection and HBV expression. HCV impaired glycolysis and fatty acid oxidation, promoting lipid accumulation whereas HBV caused lactate accumulation. In HBV-expressing cells enrichment of pyruvate dehydrogenase kinase inhibited pyruvate to acetyl-CoA conversion thereby reducing its availability for mitochondrial oxidative phosphorylation. Conclusions HBV and HCV impair mitochondrial function. HCV infection reduces lipid oxidation causing its accumulation and fatty liver disease. HBV infection affects pyruvate processing causing lactate accumulation, cellular stress, and increased risk of liver disease and cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Inhibition of Cellular Factor TM6SF2 Suppresses Secretion Pathways of Hepatitis B, Hepatitis C, and Hepatitis D Viruses.

Author

Tu, Thomas, Ajoyan, Harout, Umami, Rifqiyah Nur, Veeraraghavan, Vaishnavi, Boldbaatar, Delgerbat, Najim, Mustafa Ahmed M, Khan, Anis, Bayoumi, Ali, Ho, Vikki, Eslam, Mohammed, Berg, Thomas, Chan, Henry L Y, George, Jacob, and Douglas, Mark W

Subjects
HEPATITIS D virus, CHRONIC active hepatitis, HEPATITIS viruses, HEPATITIS C virus, VIRAL hepatitis
Abstract

Chronic viral hepatitis is caused by hepatitis B virus (HBV), hepatitis C virus (HCV), or hepatitis D virus (HDV). Despite different replication strategies, all of these viruses rely on secretion through the host endoplasmic reticulum–Golgi pathway, providing potential host targets for antiviral therapy. Knockdown of transmembrane 6 superfamily member 2 (TM6SF2) in virus cell culture models reduced secretion of infectious HCV virions, HDV virions, and HBV subviral particles. Moreover, in a cohort of people with hepatitis B, a TM6SF2 polymorphism (rs58542926 CT/TT, which causes protein misfolding and reduced TM6SF2 in the liver) correlated with lower concentrations of subviral particles in blood, complementing our previous work showing decreased HCV viral load in people with this polymorphism. In conclusion, the host protein TM6SF2 plays a key role in secretion of HBV, HCV, and HDV, providing the potential for novel pan-viral agents to treat people with chronic viral hepatitis. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Hepatitis C Virus Antiviral Drug Resistance and Salvage Therapy Outcomes Across Australia

Author

Wang, Dao Sen, primary, Phu, Amy, additional, McKee, Kristen, additional, Strasser, Simone I, additional, Sheils, Sinead, additional, Weltman, Martin, additional, Sellar, Sue, additional, Davis, Joshua S, additional, Young, Mel, additional, Braund, Alicia, additional, Farrell, Geoffrey C, additional, Blunn, Anne, additional, Harding, Damian, additional, Ralton, Lucy, additional, Muller, Kate, additional, Davison, Scott A, additional, Shaw, David, additional, Wood, Marnie, additional, Hajkowicz, Krispin, additional, Skolen, Richard, additional, Davies, Jane, additional, Tate-Baker, Jaclyn, additional, Doyle, Adam, additional, Tuma, Rhoda, additional, Hazeldine, Simon, additional, Lam, Wendy, additional, Edmiston, Natalie, additional, Zohrab, Krista, additional, Pratt, William, additional, Watson, Belinda, additional, Zekry, Amany, additional, Stephens, Carlie, additional, Clark, Paul J, additional, Day, Melany, additional, Park, Gordon, additional, Kim, Hami, additional, Wilson, Mark, additional, McGarity, Bruce, additional, Menzies, Natalie, additional, Russell, Darren, additional, Lam, Thao, additional, Boyd, Peter, additional, Kok, Jen, additional, George, Jacob, additional, and Douglas, Mark W, additional

Published
2024
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11. Epidemiology of Coronavirus Disease in Gansu Province, China, 2020

Author

Fan, Jingchun, Liu, Xiaodong, Pan, Weimin, Douglas, Mark W., and Bao, Shisan

Subjects
United States. Centers for Disease Control and Prevention -- Analysis -- International economic relations, Coronavirus infections -- Health aspects -- Analysis, Coronaviruses -- Analysis -- Health aspects, Epidemiology -- Analysis -- Health aspects, Health
Abstract

The outbreak of coronavirus disease (COVID-19) was first reported on December 31, 2019, in Wuhan, China (1). Within a few weeks, the virus had spread rapidly throughout China and within [...]

Published
2020
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12. BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial

Author

Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectious Diseases, Epi Infectieziekten Team 1, Messina, Nicole L, Pittet, Laure F, McDonald, Ellie, Moore, Cecilia, Barry, Simone, Bonten, Marc, Byrne, Anthony, Campbell, John, Croda, Julio, Croda, Mariana G, Dalcolmo, Margareth, de Almeida E Val, Fernando F, de Oliveira, Roberto D, Dos Santos, Glauce, Douglas, Mark W, Gardiner, Kaya, Gwee, Amanda, Jardim, Bruno A, Kollmann, Tobias, Lacerda, Marcus Vg, Lucas, Michaela, Lynn, David J, Manning, Laurens, Marshall, Helen, O'Connell, Abby, Perrett, Kirsten P, Post, Jeffrey J, Prat-Aymerich, Cristina, Rocha, Jorge L, Rodriguez-Baño, Jesus, Wadia, Ushma, Warris, Adilia, Davidson, Andrew, Curtis, Nigel, BRACE trial Consortium Group, Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectious Diseases, Epi Infectieziekten Team 1, Messina, Nicole L, Pittet, Laure F, McDonald, Ellie, Moore, Cecilia, Barry, Simone, Bonten, Marc, Byrne, Anthony, Campbell, John, Croda, Julio, Croda, Mariana G, Dalcolmo, Margareth, de Almeida E Val, Fernando F, de Oliveira, Roberto D, Dos Santos, Glauce, Douglas, Mark W, Gardiner, Kaya, Gwee, Amanda, Jardim, Bruno A, Kollmann, Tobias, Lacerda, Marcus Vg, Lucas, Michaela, Lynn, David J, Manning, Laurens, Marshall, Helen, O'Connell, Abby, Perrett, Kirsten P, Post, Jeffrey J, Prat-Aymerich, Cristina, Rocha, Jorge L, Rodriguez-Baño, Jesus, Wadia, Ushma, Warris, Adilia, Davidson, Andrew, Curtis, Nigel, and BRACE trial Consortium Group

Published
2024

15. Bacillus Calmette-Guérin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial

Author

Pittet, Laure F., primary, Moore, Cecilia L., additional, McDonald, Ellie, additional, Barry, Simone, additional, Bonten, Marc, additional, Campbell, John, additional, Croda, Julio, additional, Dalcolmo, Margareth, additional, Davidson, Andrew, additional, Douglas, Mark W., additional, Gardiner, Kaya, additional, Gwee, Amanda, additional, Jardim, Bruno, additional, Lacerda, Marcus V.G., additional, Lucas, Michaela, additional, Lynn, David J., additional, Manning, Laurens, additional, de Oliveira, Roberto D., additional, Perrett, Kirsten P., additional, Prat-Aymerich, Cristina, additional, Richmond, Peter C., additional, Rocha, Jorge L., additional, Rodriguez-Baño, Jesus, additional, Warris, Adilia, additional, Wood, Nicholas J., additional, Messina, Nicole L., additional, Curtis, Nigel, additional, Jamieson, Tenaya, additional, Messina, Nicole, additional, Morawakage, Thilanka, additional, Perlen, Susan, additional, Perrett, Kirsten, additional, Pittet, Laure, additional, Sastry, Amber, additional, Teo, Jia Wei, additional, Orsini, Francesca, additional, Lee, Katherine, additional, Moore, Cecilia, additional, Vidmar, Suzanna, additional, Ali, Rashida, additional, Dunn, Ross, additional, Edler, Peta, additional, Gell, Grace, additional, Goodall, Casey, additional, Hall, Richard, additional, Krastev, Ann, additional, La, Nathan, additional, McPhate, Nick, additional, Nguyen, Thao, additional, Ren, Jack, additional, Stevens, Luke, additional, Alamrousi, Ahmed, additional, Bonnici, Rhian, additional, Dang, Thanh, additional, Germano, Susie, additional, Hua, Jenny, additional, McElroy, Rebecca, additional, Razmovska, Monica, additional, Reddiex, Scott, additional, Wang, Xiaofang, additional, Anderson, Jeremy, additional, Azzopardi, Kristy, additional, Bennett-Wood, Vicki, additional, Czajko, Anna, additional, Mazarakis, Nadia, additional, McCafferty, Conor, additional, Oppedisano, Frances, additional, Ortika, Belinda, additional, Pell, Casey, additional, Spry, Leena, additional, Toh, Ryan, additional, Velagapudi, Sunitha, additional, Vlahos, Amanda, additional, Wee-Hee, Ashleigh, additional, Ramos, Pedro, additional, De La Cruz, Karina, additional, Gamage, Dinusha, additional, Karunanayake, Anushka, additional, Mezzetti, Isabella, additional, Ong, Benjamin, additional, Singh, Ronita, additional, Sooriyarachchi, Enoshini, additional, Nicholson, Suellen, additional, Cain, Natalie, additional, Brizuela, Rianne, additional, Huang, Han, additional, Abruzzo, Veronica, additional, Bealing, Morgan, additional, Bimboese, Patricia, additional, Bowes, Kirsty, additional, Burrell, Emma, additional, Chan, Joyce, additional, Cushnahan, Jac, additional, Elborough, Hannah, additional, Elkington, Olivia, additional, Fahey, Kieran, additional, Fernandez, Monique, additional, Flynn, Catherine, additional, Fowler, Sarah, additional, Andrit, Marie Gentile, additional, Gladanac, Bojana, additional, Hammond, Catherine, additional, Ma, Norine, additional, Macalister, Sam, additional, Milojevic, Emmah, additional, Mojeed, Jesutofunmi, additional, Nguyen, Jill, additional, O'Donnell, Liz, additional, Olivier, Nadia, additional, Ooi, Isabelle, additional, Reynolds, Stephanie, additional, Shen, Lisa, additional, Sherry, Barb, additional, Spotswood, Judith, additional, Wedderburn, Jamie, additional, Younes, Angela, additional, Legge, Donna, additional, Bell, Jason, additional, Cheah, Jo, additional, Cobbledick, Annie, additional, Lim, Kee, additional, Elia, Sonja, additional, Addlem, Lynne, additional, Bourke, Anna, additional, Brophy, Clare, additional, Henare, Nadine, additional, Jenkins, Narelle, additional, Machingaifa, Francesca, additional, Miller, Skye, additional, Mitchell, Kirsten, additional, Pitkin, Sigrid, additional, Wall, Kate, additional, Villanueva, Paola, additional, Crawford, Nigel, additional, Norton, Wendy, additional, Tan, Niki, additional, Chengodu, Thilakavathi, additional, Dawson, Diane, additional, Gordon, Victoria, additional, Korman, Tony, additional, O'Bryan, Jess, additional, Agius, Sophie, additional, Bannister, Samantha, additional, Bucholc, Jess, additional, Burns, Alison, additional, Camesella, Beatriz, additional, Carlin, John, additional, Ciaverella, Marianna, additional, Curtis, Maxwell, additional, Firth, Stephanie, additional, Guo, Christina, additional, Hannan, Matthew, additional, Hill, Erin, additional, Joshi, Sri, additional, Lieschke, Katherine, additional, Mathers, Megan, additional, Odoi, Sasha, additional, Rak, Ashleigh, additional, Richards, Chris, additional, Steve, Leah, additional, Stewart, Carolyn, additional, Sudbury, Eva, additional, Thomson, Helen, additional, Watts, Emma, additional, Williams, Fiona, additional, Young, Angela, additional, Glenn, Penny, additional, Kaynes, Andrew, additional, Philippart De Floy, Amandine, additional, Buchanan, Sandy, additional, Sondag, Thijs, additional, Xie, Ivy, additional, Edmund, Harriet, additional, Byrne, Bridie, additional, Keeble, Tom, additional, Ngien, Belle, additional, Noonan, Fran, additional, Wearing-Smith, Michelle, additional, Clarke, Alison, additional, Davies, Pemma, additional, Eastwood, Oliver, additional, Ellinghaus, Alric, additional, Ghieh, Rachid, additional, Hilton, Zahra, additional, Jennings, Emma, additional, Kakkos, Athina, additional, Liang, Iris, additional, Nicol, Katie, additional, O'Callaghan, Sally, additional, Osman, Helen, additional, Rajaram, Gowri, additional, Ratcliffe, Sophia, additional, Rayner, Victoria, additional, Salmon, Ashleigh, additional, Scheppokat, Angela, additional, Stevens, Aimee, additional, Street, Rebekah, additional, Toogood, Nicholas, additional, Wood, Nicholas, additional, Bahaduri, Twinkle, additional, Baulman, Therese, additional, Byrne, Jennifer, additional, Carter, Candace, additional, Corbett, Mary, additional, Dao, Aiken, additional, Desylva, Maria, additional, Dunn, Andrew, additional, Gardiner, Evangeline, additional, Joyce, Rosemary, additional, Kandasamy, Rama, additional, Munns, Craig, additional, Pelayo, Lisa, additional, Sharma, Ketaki, additional, Sterling, Katrina, additional, Uren, Caitlin, additional, Colaco, Clinton, additional, Douglas, Mark, additional, Hamilton, Kate, additional, Bartlett, Adam, additional, McMullan, Brendan, additional, Palasanthiran, Pamela, additional, Williams, Phoebe, additional, Beardsley, Justin, additional, Bergant, Nikki, additional, Lagunday, Renier, additional, Overton, Kristen, additional, Post, Jeffrey, additional, Al-Hindawi, Yasmeen, additional, Barney, Sarah, additional, Byrne, Anthony, additional, Mead, Lee, additional, Plit, Marshall, additional, Lynn, David, additional, Benson, Saoirse, additional, Blake, Stephen, additional, Botten, Rochelle, additional, Chern, Tee Yee, additional, Eden, Georgina, additional, Griffith, Liddy, additional, James, Jane, additional, Lynn, Miriam, additional, Markow, Angela, additional, Sacca, Domenic, additional, Stevens, Natalie, additional, Wesselingh, Steve, additional, Doran, Catriona, additional, Sawka, Alice, additional, Evans, Sue, additional, Goodchild, Louise, additional, Heath, Christine, additional, Krieg, Meredith, additional, Marshall, Helen, additional, McMillan, Mark, additional, Walker, Mary, additional, Richmond, Peter, additional, Amenyogbe, Nelly, additional, Anthony, Christina, additional, Arnold, Annabelle, additional, Arrowsmith, Beth, additional, Ben-Othman, Rym, additional, Clark, Sharon, additional, Dunnill, Jemma, additional, Eiffler, Nat, additional, Ewe, Krist, additional, Finucane, Carolyn, additional, Flynn, Lorraine, additional, Gibson, Camille, additional, Hartnell, Lucy, additional, Hollams, Elysia, additional, Hutton, Heidi, additional, Jarvis, Lance, additional, Jones, Jane, additional, Jones, Jan, additional, Jones, Karen, additional, Kent, Jennifer, additional, Kollmann, Tobias, additional, Lalich, Debbie, additional, Lee, Wenna, additional, Lim, Rachel, additional, McAlister, Sonia, additional, McDonald, Fiona, additional, Meehan, Andrea, additional, Minhaj, Asma, additional, Montgomery, Lisa, additional, O'Donnell, Melissa, additional, Ong, Jaslyn, additional, Ong, Joanne, additional, Parkin, Kimberley, additional, Perez, Glady, additional, Power, Catherine, additional, Rezazadeh, Shadie, additional, Richmond, Holly, additional, Rogers, Sally, additional, Schultz, Nikki, additional, Shave, Margaret, additional, Skut, Patrycja, additional, Stiglmayer, Lisa, additional, Truelove, Alexandra, additional, Wadia, Ushma, additional, Wallace, Rachael, additional, Waring, Justin, additional, England, Michelle, additional, Latkovic, Erin, additional, Herrmann, Susan, additional, Lacerda, Marcus, additional, Andrade, Paulo Henrique, additional, Barbosa, Fabiane Bianca, additional, Barros, Dayanne, additional, Brasil, Larissa, additional, Capella, Ana Greyce, additional, Castro, Ramon, additional, Costa, Erlane, additional, de Souza, Dilcimar, additional, Dias, Maianne, additional, Dias, José, additional, Ferreira, Klenilson, additional, Figueiredo, Paula, additional, Freitas, Thamires, additional, Furtado, Ana Carolina, additional, Gama, Larissa, additional, Godinho, Vanessa, additional, Gouy, Cintia, additional, Hinojosa, Daniele, additional, Jardim, Tyane, additional, Junior, Joel, additional, Lima, Augustto, additional, Maia, Bernardo, additional, Marins, Adriana, additional, Mazurega, Kelry, additional, Medeiros, Tercilene, additional, Melo, Rosangela, additional, Moraes, Marinete, additional, Nascimento, Elizandra, additional, Neves, Juliana, additional, Oliveira, Maria Gabriela, additional, Oliveira, Thais, additional, Oliveira, Ingrid, additional, Otsuka, Arthur, additional, Paes, Rayssa, additional, Pereira, Handerson, additional, Pereira, Gabrielle, additional, Prado, Christiane, additional, Queiroz, Evelyn, additional, Rodrigues, Laleyska, additional, Rodrigues, Bebeto, additional, Sampaio, Vanderson, additional, Santos, Anna Gabriela, additional, Santos, Daniel, additional, Santos, Tilza, additional, Santos, Evelyn, additional, Sartim, Ariandra, additional, Silva, Ana Beatriz, additional, Silva, Juliana, additional, Silva, Emanuelle, additional, Simão, Mariana, additional, Soares, Caroline, additional, Sousa, Antonny, additional, Trindade, Alexandre, additional, Val, Fernando, additional, Vasconcelos, Adria, additional, Vasconcelos, Heline, additional, Abreu, Carolinne, additional, Almeida, Katya Martinez, additional, Bitencourt de Andrade, Camila, additional, Campos Angelo, Jhenyfer Thalyta, additional, Gonçalvez de Araújo Arcanjo, Ghislaine, additional, Silva Menezes Arruda, Bianca Maria, additional, Ayala, Wellyngthon Espindola, additional, Refosco Barbosa, Adelita Agripina, additional, Vieira Batista, Felipe Zampieri, additional, de Morais Batista, Fabiani, additional, de Jesus Costa, Miriam, additional, Croda, Mariana Garcia, additional, Alves da Cruz, Lais, additional, Pereira Diogo, Roberta Carolina, additional, Dutra Escobar, Rodrigo Cezar, additional, Fernandes, Iara Rodrigues, additional, Figueiredo, Leticia Ramires, additional, Cavalcanti Gonçalves, Leandro Galdino, additional, Lahdo, Sarita, additional, Lencina, Joyce dos Santos, additional, Teodoro de Lima, Guilherme, additional, Matos, Larissa Santos, additional, Leopoldina Meireles, Bruna Tayara, additional, Moreira, Debora Quadros, additional, Silva Muranaka, Lilian Batista, additional, de Oliveira, Adriely, additional, Warszawski de Oliveira, Karla Regina, additional, Vieira de Oliveira, Matheus, additional, Dias de Oliveira, Roberto, additional, Souza de Almeida dos Reis Pereira, Andrea Antonia, additional, Puga, Marco, additional, Ramos, Caroliny Veron, additional, Souza da Rosa, Thaynara Haynara, additional, Lopes dos Santos, Karla, additional, Ribeiro dos Santos, Claudinalva, additional, Leopoldina dos Santos, Dyenyffer Stéffany, additional, Santos, Karina Marques, additional, Pereira da Silva, Paulo César, additional, Rocha da Silva, Paulo Victor, additional, Silva, Débora dos Santos, additional, Vieira da Silva, Patricia, additional, Freitas da Rosa Soares, Bruno, additional, Sperotto, Mariana Gazzoni, additional, Tadokoro, Mariana Mayumi, additional, Tsuha, Daniel, additional, Ramos Vieira, Hugo Miguel, additional, Pretti Dalcolmo, Margareth Maria, additional, Lopes Alves da Paixão, Cíntia Maria, additional, Corrêa E Castro, Gabriela, additional, Collopy, Simone Silva, additional, da Costa Silva, Renato, additional, Almeida da Silveira, Samyra, additional, Da-Cruz, Alda Maria, additional, Maria da Silva Passos de Carvalho, Alessandra, additional, de Cássia Batista, Rita, additional, Silva De Freitas, Maria Luciana, additional, Gerhardt de Oliveira Ferreira, Aline, additional, Conceição de Souza, Ana Paula, additional, Doblas, Paola Cerbino, additional, Alcoforado da Silva dos Santos, Ayla, additional, Cristine de Moraes dos Santos, Vanessa, additional, Alves dos Santos Gomes, Dayane, additional, Fortunato, Anderson Lage, additional, Gomes-Silva, Adriano, additional, Gonçalves, Monique Pinto, additional, Garcia Meireless Junior, Paulo Leandro, additional, Martins da Costa Carvalho, Estela, additional, Motta, Fernando do Couto, additional, Olivo de Mendonça, Ligia Maria, additional, Pandine, Girlene dos Santos, additional, Plácido Pereira, Rosa Maria, additional, Maia, Ivan Ramos, additional, Luiz da Rocha, Jorge, additional, Paiva Romano, João Victor, additional, Santos, Glauce dos, additional, Fernandes da Silva, Erica, additional, Mendonça Teixeira de Siqueira, Marilda Agudo, additional, Prudêncio Soares, Ágatha Cristinne, additional, Arroyo, Sandra Franch, additional, Besten, Henny Ophorst-den, additional, Boon, Anna, additional, Brakke, Karin M., additional, Janssen, Axel, additional, Koopmans, Marijke A.H., additional, Lemmens, Toos, additional, Leurink, Titia, additional, Septer-Bijleveld, Engelien, additional, Stadhouders, Kimberly, additional, Troeman, Darren, additional, van der Waal, Marije, additional, van Opdorp, Marjoleine, additional, van Sluis, Nicolette, additional, Wolters, Beatrijs, additional, Kluytmans, Jan, additional, Romme, Jannie, additional, van den Bijllaardt, Wouter, additional, van Mook, Linda, additional, Rijen, M.M.L (Miranda) van, additional, Filius, P.M.G., additional, Gisolf, Jet, additional, Greven, Frances, additional, Huijbens, Danique, additional, Hassing, Robert Jan, additional, Pon, R.C., additional, Preijers, Lieke, additional, van Leusen, J.H., additional, Verheij, Harald, additional, Boersma, Wim, additional, Brans, Evelien, additional, Kloeg, Paul, additional, Molenaar-Groot, Kitty, additional, Nguyen, Nhat Khanh, additional, Paternotte, Nienke, additional, Rol, Anke, additional, Stooper, Lida, additional, Dijkstra, Helga, additional, Eggenhuizen, Esther, additional, Huijs, Lucas, additional, Moorlag, Simone, additional, Netea, Mihai, additional, Pranger, Eva, additional, Taks, Esther, additional, Oever, Jaap ten, additional, Heine, Rob ter, additional, Blauwendraat, Kitty, additional, Meek, Bob, additional, Erkaya, Isil, additional, Harbech, Houda, additional, Roescher, Nienke, additional, Peeters, Rifka, additional, Riele, Menno te, additional, Zhou, Carmen, additional, Calbo, Esther, additional, Marti, Cristina Badia, additional, Palomares, Emma Triviño, additional, Porcuna, Tomás Perez, additional, Barriocanal, Anabel, additional, Barriocanal, Ana Maria, additional, Casas, Irma, additional, Dominguez, Jose, additional, Esteve, Maria, additional, Lacoma, Alicia, additional, Latorre, Irene, additional, Molina, Gemma, additional, Molina, Barbara, additional, Rosell, Antoni, additional, Vidal, Sandra, additional, Barrera, Lydia, additional, Bustos, Natalia, additional, Calderón, Ines Portillo, additional, Campos, David Gutierrez, additional, Carretero, Jose Manuel, additional, Castellano, Angel Dominguez, additional, Compagnone, Renato, additional, Ramirez de Arellano, Encarnacion, additional, Serna, Almudena de la, additional, Dolores del Toro Lopez, Maria, additional, Clement Espindola, Marie-Alix, additional, Martin Gutierrez, Ana Belen, additional, Hernandez, Alvaro Pascual, additional, Jiménez, Virginia Palomo, additional, Moreno, Elisa, additional, Navarrete, Nicolas, additional, Paño, Teresa Rodriguez, additional, Rodríguez-Baño, Jesús, additional, Tristán, Enriqueta, additional, Rios Villegas, Maria Jose, additional, Garces, Atsegiñe Canga, additional, Amo, Erika Castro, additional, Guerrero, Raquel Coya, additional, Goikoetxea, Josune, additional, Jorge, Leticia, additional, Perez, Cristina, additional, Fariñas Álvarez, María Carmen, additional, Cuadra, Manuel Gutierrez, additional, Arnaiz de las Revillas Almajano, Francisco, additional, Garcia, Pilar Bohedo, additional, Poderos, Teresa Giménez, additional, Rico, Claudia González, additional, Sanchez, Blanca, additional, Valero, Olga, additional, Vega, Noelia, additional, Barnes, Anna, additional, Catterick, Helen, additional, Cranston, Tim, additional, Dawe, Phoebe, additional, Fletcher, Emily, additional, Fouracre, Liam, additional, Gifford, Alison, additional, Kirkwood, John, additional, Martin, Christopher, additional, McAnew, Amy, additional, Mitchell, Marcus, additional, Newman, Georgina, additional, O'Connell, Abby, additional, Onysk, Jakob, additional, Quinn, Lynne, additional, Rhodes, Shelley, additional, Stone, Samuel, additional, Symons, Lorrie, additional, Tripp, Harry, additional, Watkins, Darcy, additional, Whale, Bethany, additional, Harding, Alex, additional, Lockhart, Gemma, additional, Sidaway-Lee, Kate, additional, Hilton, Sam, additional, Manton, Sarah, additional, Webber-Rookes, Daniel, additional, Winder, Rachel, additional, Moore, James, additional, Bateman, Freya, additional, Gibbons, Michael, additional, Knight, Bridget, additional, Moss, Julie, additional, Statton, Sarah, additional, Studham, Josephine, additional, Hall, Lydia, additional, Moyle, Will, additional, and Venton, Tamsin, additional

Published
2023
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18. FibroGENE: A gene-based model for staging liver fibrosis

Author

Eslam, Mohammed, Hashem, Ahmed M., Romero-Gomez, Manuel, Berg, Thomas, Dore, Gregory J., Mangia, Alessandra, Chan, Henry Lik Yuen, Irving, William L., Sheridan, David, Abate, Maria Lorena, Adams, Leon A., Weltman, Martin, Bugianesi, Elisabetta, Spengler, Ulrich, Shaker, Olfat, Fischer, Janett, Mollison, Lindsay, Cheng, Wendy, Nattermann, Jacob, Riordan, Stephen, Miele, Luca, Kelaeng, Kebitsaone Simon, Ampuero, Javier, Ahlenstiel, Golo, McLeod, Duncan, Powell, Elizabeth, Liddle, Christopher, Douglas, Mark W., Booth, David R., and George, Jacob

Published
2016
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19. A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms

Author

Sharkawy, Rasha El, Bayoumi, Ali, Metwally, Mayada, Mangia, Alessandra, Berg, Thomas, Romero-Gomez, Manuel, Abate, Maria Lorena, Irving, William L., Sheridan, David, Dore, Gregory J., Spengler, Ulrich, Lampertico, Pietro, Bugianesi, Elisabetta, Weltman, Martin, Mollison, Lindsay, Cheng, Wendy, Riordan, Stephen, Santoro, Rosanna, Gallego-Durán, Rocío, Fischer, Janett, Nattermann, Jacob, D’Ambrosio, Roberta, McLeod, Duncan, Powell, Elizabeth, latchoumanin, Olivier, Thabet, Khaled, Najim, Mustafa A. M., Douglas, Mark W., Liddle, Christopher, Qiao, Liang, George, Jacob, Eslam, Mohammed, and International Liver Disease Genetics Consortium (ILDGC)

Published
2019
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20. Bacillus Calmette-Guérin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial

Author

Bill & Melinda Gates Foundation, Minderoo Foundation, Royal Children's Hospital Foundation, Health Services Union New South Wales Branch, Peter Sowerby Foundation, SA Health, Insurance Advisernet Foundation, NAB Foundation, Calvert-Jones Foundation, Modara Pines Charitable Foundation, United Health Foundation, Epworth HealthCare, National Health and Medical Research Council (Australia), Swiss National Science Foundation, Pittet, Laure F., Moore, Cecilia L., McDonald, Ellie, Barry, Simone, Bonten, Marc, Campbell, John, Croda, Julio, Dalcolmo, Margareth, Davidson, Andrew, Douglas, Mark W., Gardiner, Kaya, Gwee, Amanda, Jardim, Bruno, Lacerda, Marcus V. G., Lucas, Michaela, Lynn, David J., Manning, Laurens, Oliveira, Roberto D. de, Perrett, Kirsten P., Prat-Aymerich, Cristina, Richmond, Peter C., Rocha, Jorge L., Rodríguez-Baño, Jesús, Warris, Adilia, Wood, Nicholas J., Messina, Nicole L., Curtis, Nigel, BRACE Trial Consortium Group, Bill & Melinda Gates Foundation, Minderoo Foundation, Royal Children's Hospital Foundation, Health Services Union New South Wales Branch, Peter Sowerby Foundation, SA Health, Insurance Advisernet Foundation, NAB Foundation, Calvert-Jones Foundation, Modara Pines Charitable Foundation, United Health Foundation, Epworth HealthCare, National Health and Medical Research Council (Australia), Swiss National Science Foundation, Pittet, Laure F., Moore, Cecilia L., McDonald, Ellie, Barry, Simone, Bonten, Marc, Campbell, John, Croda, Julio, Dalcolmo, Margareth, Davidson, Andrew, Douglas, Mark W., Gardiner, Kaya, Gwee, Amanda, Jardim, Bruno, Lacerda, Marcus V. G., Lucas, Michaela, Lynn, David J., Manning, Laurens, Oliveira, Roberto D. de, Perrett, Kirsten P., Prat-Aymerich, Cristina, Richmond, Peter C., Rocha, Jorge L., Rodríguez-Baño, Jesús, Warris, Adilia, Wood, Nicholas J., Messina, Nicole L., Curtis, Nigel, and BRACE Trial Consortium Group

Abstract

[Background] Recurrences of herpes simplex virus (HSV) in the orofacial region (herpes labialis or cold sores) impact quality-of-life. We aimed to study whether the bacille Calmette-Guérin (BCG) vaccine can attenuate cold sore recurrences through off-target immunomodulatory effects., [Methods] In this nested randomised controlled trial within the multicentre, phase 3 BRACE trial, 6828 healthcare workers were randomised in 36 sites in Australia, the Netherlands, Spain, the United Kingdom and Brazil, to receive BCG-Denmark or no BCG (1:1 ratio using a web-based procedure) and followed for 12 months with 3-monthly questionnaires. Exclusion criteria included contraindication to BCG vaccine or previous vaccination with BCG within the past year, any other live-attenuated vaccine within the last month, or any COVID-specific vaccine. The intervention group received one intradermal dose of 0.1 mL of BCG-Denmark corresponding to 2−8 x 105 colony forming units of Mycobacterium bovis, Danish strain 1331. The primary outcome was the difference in restricted mean survival time (i.e., time to first cold-sore recurrence), in participants with frequent recurrent herpes labialis (≥4 recurrences/year), analysed by intention-to-treat. Secondary outcomes addressed additional questions, including analyses in other sub-populations. Adverse events were monitored closely during the first 3 months and were reported in all participants who received one dose of study drug according to intervention received. The BRACE trial is registered with ClinicalTrials.gov, NCT04327206., [Findings] Between March 30, 2020 and February 18, 2021, 84 individuals with frequent recurrent cold sores were randomly assigned to BCG (n = 38) or control (n = 46). The average time to first cold-sore recurrence was 1.55 months longer in the BCG group (95% CI 0.27–2.82, p = 0.02) than the control group (hazard ratio 0.54, 95% CI 0.32–0.91; intention-to-treat). The beneficial effect of BCG was greater in the as-treated population (difference 1.91 months, 95% CI 0.69–3.12, p = 0.003; hazard ratio 0.45, 95% CI 0.26–0.76). In prespecified subgroup analyses, only sex modified the treatment effect (interaction p = 0.007), with benefit restricted to males. Over 12 months, a greater proportion of participants in the BCG group compared with the control group reported a decrease in duration (61% vs 21%), severity (74% vs 21%), frequency (55% vs 21%), and impact on quality of life (42% vs 15%) of cold sore recurrences. In participants who had ever had a cold sore, there was also a decrease in self-reported burden of recurrences in the BCG group. In participants who had never had a cold sore, there was an increased risk of a first episode in the BCG group (risk difference 1.4%; 95% CI 0.3–2.6%, p = 0.02). There were no safety concerns., [Interpretation] BCG-Denmark vaccination had a beneficial effect on herpes labialis, particularly in males with frequent recurrences, but may increase the risk of a first cold sore.

Published
2023

21. Telehealth Use and Legal Considerations in Drug Health Services During Pandemics: Systematic Scoping Review.

Author

Jefferies, Meryem, Graham, Robert, Tracy, Marguerite, Read, Scott, Eslam, Mohammed, Douglas, Mark W, and George, Jacob

Subjects
MEDICAL personnel, LEGAL documents, MEDICAL malpractice, MEDICAL databases, OUTPATIENT medical care
Abstract

Background: The COVID-19 pandemic impacted patients with substance use disorder (SUD) more than the general population and resulted in substantially increased emergency department admissions. Routine care of patients attending drug health services during the pandemic transitioned, with telehealth being important in delivering appropriate care. However, telehealth introduces unique risks such as privacy, confidentiality, and data safety. Providing health care through telehealth may fail if the legal impacts are not fully identified and acted on by health professionals. It also poses unintended risks for patients and can result in ineffectiveness, damages, medical negligence, and detracts from the best intentions of governments and health professionals. Understanding the legal framework ensures that medical professionals operate health care through telehealth within the law. Providing health care successfully through telehealth depends on the balance between innovation and legal compliance. By considering these aspects, clinicians and practitioners can provide effective and safe telehealth services during pandemics or any other natural disaster. Objective: We aimed to explore the legal impact of autonomy consent, confidentiality, privacy, data security, professional indemnity, and liability when delivering telehealth to patients with SUD. The scoping review also aimed to provide legal, ethical, and clinical considerations to minimize legal risks with using telehealth in drug health service outpatient settings. Methods: We performed a scoping review to provide an overview of existing research, statutes, and case laws for the incorporation of clinical, ethical, and legal considerations into telehealth use. Six databases for medical and 6 databases for legal publications were searched, as well as Australian national and selected international regulatory standards. Medical articles published up to June 2022 were included in this review. Our search yielded 1436 publications, 614 abstracts were reviewed, and 80 published studies met the inclusion criteria from 614 legal and medical search results. Current regulations related to technology use in drug health services, relevant cases, and international regulatory standards are discussed. Results: In total, 43 legal documents including 15 statutes, 4 case laws, and 37 medical publications were reviewed. The themes arising from the literature were consent and autonomy (20/80, 25%), confidentiality (8/80, 10%), privacy (8/80, 10%), data security (7/80, 9%), and professional indemnity issues (3/80, 4%) in telehealth use. Further, 24 studies identified legal issues associated with telehealth use in patients with SUD. Conclusions: Our review identified potential legal issues associated with telehealth use in patients with SUD. Several legal and medical research articles provide frameworks, codes of conduct, or suggestions for clinicians to consider, but there was little discussion or evidence of how legal considerations are being applied when providing telehealth consultations at drug health services. Clinicians should be aware of the medicolegal implications when providing health care via telehealth at drug health services. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Inhibition of cellular factor TM6SF2 suppresses secretion pathways of Hepatitis B, Hepatitis C and Hepatitis D viruses

Author

Tu, Thomas, primary, Ajoyan, Harout, additional, Umami, Rifqiyah nur, additional, Veeraraghavan, Vaishnavi, additional, Najim, Mustafa Ahmed M, additional, Khan, Anis, additional, Bayoumi, Ali, additional, Ho, Vikki, additional, Eslam, Mohammed, additional, Berg, Thomas, additional, Chan, Henry L Y, additional, George, Jacob, additional, and Douglas, Mark W, additional

Published
2023
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26. COVID-19 Impact on Australian Patients with Substance Use Disorders: Emergency Department Admissions in Western Sydney before Vaccine Roll Out

Author

Jefferies, Meryem, primary, Rashid, Harunor, additional, Graham, Robert, additional, Read, Scott, additional, Banik, Gouri R., additional, Lam, Thao, additional, Njiomegnie, Gaitan F., additional, Eslam, Mohammed, additional, Zhao, Xiaojing, additional, Ahmed, Nausheen, additional, Douglas, Mark W., additional, and George, Jacob, additional

Published
2022
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27. Global multi-stakeholder endorsement of the MAFLD definition

Author

Abate, Maria Lorena, Abbas, Bahaa, Abbassy, Ahmed Amr, Abd El Ghany, Waleed, Abd Elkhalek, Amira, Abd ElMajeed, Emad, Abdalgaber, Mohammad, AbdAllah, Mohamed, Abdallah, Marwa, Abdallah, Nourhan, Abdelaleem, Shereen, Abdelghani, Yasser, Abdelghany, Wael, Abdelhalim, Safaa Mohamed, Abdelhamid, Wafaa, Abdelhamid, Nehal, Abdelkader, Nadia A., Abdelkreem, Elsayed, Abdelmohsen, Aly Mohamed, Abdelrahman, Awny Ali, Abd-elsalam, Sherief M, Abdeltawab, Doaa, Abduh, Abdulbaset, Abdulhakam, Nada, Abdulla, Maheeba, Abedpoor, Navid, Abenavoli, Ludovico, Åberg, Fredrik, Ablack, Omala, Abo elftouh, Mostafa, Abo-Amer, Yousry Esam-Eldin, Aboubkr, Ashraf, Aboud, Alaa, Abouelnaga, Amr M., Aboufarrag, Galal A., Aboutaleb, Ashraf, Abundis, Leticia, Adalı, Gupse, Adames, Enrique, Adams, Leon, Adda, Danjuma, Adel, Noor, Adel, Nada, Adel Sayed, Muhammad, Afaa, Taiba Jibril, Afredj, Nawal, Aghayeva, Gulnara, Aghemo, Alessio, Aguilar-Salinas, Carlos A., Ahlenstiel, Golo, Ahmady, Walid, Ahmed, Wafaa, Ahmed, Amira, Ahmed, Samah Nasser, Ahmed, Heba Mostafa, Ahmed, Rasha, Aigner, Elmar, Akarsu, Mesut, Akroush, Maisam, Akyuz, Umit, Al Mahtab, Mamun, Al Qadiri, Tahani, Al Rawahi, Yusriya, AL rubaee, Razzaq, Al Saffar, Muna, Alam, Shahinul, Al-Ani, Zaid, Albillos, Agustín, Alboraie, Mohamed, Al-Busafi, Said, Al-Emam, Mohamed, Alharthi, Jawaher, Ali, Kareem, Ali, Basma Abdelmoez, Ali, Mohammad, Ali, Raja Affendi Raja, Alisi, Anna, AL-Khafaji, Ali Raad, Alkhatry, Maryam, Aller, Rocio, Almansoury, Yahya, Al-Naamani, Khalid, Alnakeeb, Alaa, Alonso, Anna, Alqahtani, Saleh A., Alrabadi, Leina, Alswat, Khalid, Altaher, Mahir, Altamimi, Turki, Altamirano, Jose, Alvares-da-Silva, Mario R., Aly, Elsragy Adel M., Alzahaby, Amgad, Alzamzamy, Ahmed, Amano, Keisuke, Amer, Maysa A., Amin, Mona A., Amin, Sayed A., Amir, Ashraf A., Ampuero, Javier, Anas, Noha, Andreone, Pietro, Andriamandimby, Soa Fy, Anees, Mahmoud, Angela, Peltec, Antonios, Manal, Arafat, Wael, Araya, Jose Moreno, Armendariz-Borunda, Juan, Armstrong, Matthew J., Ashktorab, Hassan, Aspichueta, Patricia, Assal, Fathia, Atef, Mira, Attia, Dina, Atwa, Hoda, Awad, Reham, Awad, Mohyeldeen Abd Elaziz, Awny, Sally, Awolowo, Obafemi, Awuku, Yaw Asante, Ayada, Ibrahim, Aye, Than Than, Ayman, Sherif, Ayman, Hedy, Ayoub, Hesham, Azmy, Hosny M., Babaran, Romiro P., Badreldin, Omneya, Badry, Ahmed, Bahçecioğlu, İbrahim Halil, Bahour, Amira, Bai, Jiajia, Balaban, Yasemin, Balasubramanyam, Muthuswamy, Bamakhrama, Khaled, Banales, Jesus M, Bangaru, Babu, Bao, Jianfeng, Barahona, Jorge Suazo, Barakat, Salma, Barbalho, Sandra Maria, Barbra, Bikwa, Barranco, Beatriz, Barrera, Francisco, Baumann, Ulrich, Bazeed, Shamardan, Bech, Eva, Benayad, Aourarh, Benesic, Andreas, Bernstein, David, Bessone, Fernando, Birney, Susie, Bisseye, Cyrille, Blake, Martin, Bobat, Bilal, Bonfrate, Leonilde, Bordin, Dmitry S, Bosques-Padilla, Francisco, Boursier, Jerome, Boushab, Boushab Mohamed, Bowen, David, Bravo, Patricia Medina, Brennan, Paul N, Bright, Bisi, Broekaert, Ilse, Buque, Xabier, Burgos-Santamaría, Diego, Burman, Julio, Busetto, Luca, Byrne, Chris D., Cabral-Prodigalidad, Patricia Anne I., Cabrera-Alvarez, Guillermo, Cai, Wei, Cainelli, Francesca, Caliskan, Ali Riza, Canbay, Ali, Cano-Contreras, Ana, Cao, Hai-Xia, Cao, Zhujun, Carrion, Andres, Carubbi, Francesca, Casanovas, Teresa, Castellanos Fernández, Marlen Ivón, Chai, Jin, Chan, Siew Pheng, Charatcharoenwitthaya, Phunchai, Chavez-Tapia, Norberto, Chayama, Kazuaki, Chen, Jinjun, Chen, Lin, Chen, Zhong-Wei, Chen, Huiting, Chen, Sui-Dan, Chen, Qiang, Chen, Yaxi, Chen, Gang, Chen, En-Quang, Chen, Fei, Chen, Pei-Jer, Cheng, Robert, Cheng, Wendy, Chieh, Jack Tan Wei, Chokr, Imad, Cholongitas, Evangelos, Choudhury, Ashok, Chowdhury, Abhijit, Chukwudike, Evaristus Sunday, Ciardullo, Stefano, Clayton, Michelle, Clement, Karine, Cloa, Marie Michelle, Coccia, Cecilia, Collazos, Cristina, Colombo, Massimo, Cosar, Arif Mansur, Cotrim, Helma Pinchemel, Couillerot, Joris, Coulibaly, Alioune, Crespo, Gonzalo, Crespo, Javier, Cruells, Maria, Cua, Ian Homer Y., Dabbous, Hesham K., Dalekos, George N, D'Alia, Patricia, Dan, Li, Dao, Viet Hang, Darwish, Mostafa, Datz, Christian, Davalos-Moscol, Milagros B, Dawoud, Heba, de Careaga, Blanca Olaechea, de Knegt, Robert, de Ledinghen, Victor, de Silva, Janaka, Debzi, Nabil, Decraecker, Marie, Del Pozo, Elvira, Delgado, Teresa C, Delgado-Blanco, Manuel, Dembiński, Łukasz, Depina, Adilson, Derbala, Moutaz, Desalegn, Hailemichael, Desbois-Mouthon, Christèle, Desoky, Mahmoud, Dev, Anouk, Di Ciaula, Agostino, Diago, Moisés, Diallo, Ibrahima, Díaz, Luis Antonio, Dirchwolf, Melisa, Dongiovanni, Paola, Dorofeyev, Andrriy, Dou, Xiaoguang, Douglas, Mark W., Doulberis, Michael, Dovia, Cecil K., Doyle, Adam, Dragojević, Ivana, Drenth, Joost PH, Duan, Xuefei, Dulskas, Audrius, Dumitrascu, Dan L, Duncan, Oliver, Dusabejambo, Vincent, Dwawhi, Rev. Shem N.A., Eiketsu, Sho, El Amrousy, Doaa, El Deeb, Ahmed, El Deriny, Ghada, El Din, Hesham Salah, El Kamshishy, Salwa, El Kassas, Mohamed, El Raziky, Maissa, Elagamy, Osama A, Elakel, Wafaa, Elalfy, Dina, Elaraby, Hanaa, ElAwady, Heba, Elbadawy, Reda, Eldash, Hanaa Hassan, Eldefrawy, Manal S., Elecharri, Carol Lezama, Elfaramawy, Amel, Elfatih, Mohammed, Elfiky, Mahmoud, Elgamsy, Mohamed, Elgendy, Mohamed, El-Guindi, Mohamed A., Elhussieny, Nagi, Eliwa, Ahmed Maher, Elkabbany, Zeineb, El-Khayat, Hesham, El-Koofy, Nehal M., Elmetwalli, Alaa, Elrabat, Amr, El-Raey, Fathiya, Elrashdy, Fatma, Elsahhar, Medhat, Elsaid, Esraa M., Elsayed, Shimaa, Elsayed, Hany, Elsayed, Aly, Elsayed, Amr M., Elsayed, Hamdy, El-Serafy, Magdy, Elsharkawy, Ahmed M., Elsheemy, Reem Yehia, Elshemy, Eman Elsayed, Elsherbini, Sara, Eltoukhy, Naglaa, Elwakil, Reda, Emad, Ola, Emad, Shaimaa, Embabi, Mohamed, Ergenç, Ilkay, Ermolova, Tatiana, Esmat, Gamal, Esmat, Doaa M., Estupiñan, Enrique Carrera, Ettair, Said, Eugen, Tcaciuc, Ezz-Eldin, Mohammed, Falcón, Lidia Patricia Valdivieso, Fan, Yu-Chen, Fandari, Samah, Farag, Mahmoud, Farahat, Taghreed Mohamed, Fares, Eman M., Fares, Michael, Fassio, Eduardo, Fathy, Hayam, Fathy, Dina, Fathy, Wael, Fayed, Soheir, Feng, Dan, Feng, Gong, Fernández-Bermejo, Miguel, Ferreira, Cristina Targa, Ferrer, Javier Díaz, Forbes, Alastair, Fouad, Rabab, Fouad, Hanan M., Frisch, Tove, Fujii, Hideki, Fukunaga, Shuhei, Fukunishi, Shinya, Fulya, Hacer, Furuhashi, Masato, Gaber, Yasmine, Galang, Augusto Jose G., Gallardo, Jacqueline Cordova, Galloso, Rocío, Gamal, Mahmoud, Gamal, Reham, Gamal, Hadeel, Gan, Jian, Ganbold, Anar, Gao, Xin, Garas, George, Garba, Tony, García-Cortes, Miren, García-Monzón, Carmelo, García-Samaniego, Javier, Gastaldelli, Amalia, Gatica, Manuel, Gatley, Elizabeth, Gegeshidze, Tamar, Geng, Bin, Ghazinyan, Hasmik, Ghoneem, Salma, Giacomelli, Luca, Giannelli, Gianluigi, Giannini, Edoardo G., Giefer, Matthew, Ginès, Pere, Girala, Marcos, Giraudi, Pablo J, Goh, George Boon-Bee, Gomaa, Ahmed Ali, Gong, Benbingdi, Gonzales, Dina Hilda C., Gonzalez, Humberto C., Gonzalez-Huezo, Maria Saraí, Graupera, Isabel, Grgurevic, Ivica, Grønbæk, Henning, Gu, Xuelian, Guan, Lin, Gueye, Ibrahima, Guingané, Alice Nanelin, Gul, Ozen Oz, Gul, Cuma Bulent, Guo, Qing, Gupta, Pramendra Prasad, Gurakar, Ahmet, Gutierrez, Juan Carlos Restrepo, Habib, Ghada, Hafez, Azaa, Hagman, Emilia, Halawa, Eman, Hamdy, Osama, Hamed, Abd Elkhalek, Hamed, Dina H., Hamid, Saeed, Hamoudi, Waseem, Han, Yu, Haridy, James, Haridy, Hanan, Harris, David C H Harris, Hart, Michael, Hasan, Fuad, Hashim, Almoutaz, Hassan, Israa, Hassan, Ayman, Hassan, Essam Ali, Hassan, Adel Ahmed, Hassan, Magda Shehata, Hassanin, Fetouh, Hassnine, Alshymaa, Haukeland, John Willy, Hawal, Amr Ismael M., He, Jinfan, He, Qiong, He, Yong, He, Fang-Ping, Hegazy, Mona, Hegazy, Adham, Henegil, Osama, Hernández, Nelia, Hernández-Guerra, Manuel, Higuera-de-la-Tijera, Fatima, Hindy, Ibrahim, Hirota, Keisuke, Ho, Lee Chi, Hodge, Alexander, Hosny, Mohamed, Hou, Xin, Huang, Jiao-Feng, Huang, Yan, Huang, Zhifeng, Huang, Yuan, Huang, Ang, Huang, Xiao-Ping, Hui-ping, Sheng, Hunyady, Bela, Hussein, Mennatallah A., Hussein, Osama, Hussien, Shahinaz Mahmoud, Ibáñez-Samaniego, Luis, Ibdah, Jamal, Ibrahim, Luqman, Ibrahim, Miada, Ibrahim, Ibrahim, Icaza-Chávez, Maria E., Idelbi, Sahar, Idilman, Ramazan Idilman, Ikeda, Mayumi, Indolfi, Giuseppe, Invernizzi, Federica, Irshad, Iram, Isa, Hasan Mohamed Ali, Iskandar, Natacha Jreige, Ismaiel, Abdulrahman, Ismail, Mariam, Ismail, Zulkifli, Ismail, Faisal, Iwamoto, Hideki, Jack, Kathryn, Jacob, Rachael, Jafarov, Fuad, Jafri, Wasim, Jahshan, Helen, Jalal, Prasun K, Jancoriene, Ligita, Janicko, Martin, Jayasena, Hiruni, Jefferies, Meryem, Jha, Vivekanand, Ji, Fanpu, Ji, Yaqiu, Jia, Jidong, Jiang, Changtao, Jiang, Ni, Jiang, Zong-zhe, Jin, Xing, Jin, Yi, Jing, Xu, Jingyu, Qian, Jinjolava, Maia, Jong, FX Himawan Haryanto, Jucov, Alina, Julius, Ibecheole, Kaddah, Mona, Kamada, Yoshihiro, kamal, Abobakr, Kamal, Enas Mohamed, Kamel, Ashraf Sayed, Kao, Jia-Horng, Karin, Maja, Karlas, Thomas, Kashwaa, Mohammad, Katsidzira, Leolin, Kaya, Eda, Kayasseh, M.Azzam, Keenan, Bernadette, Keklikkiran, Caglayan, Keml, William, Khalaf, Deia K., Khalefa, Rofida, Khamis, Sherin, Khater, Doaa, khattab, Hamed, Khavkin, Anatoly, Khlynova, Olga, Khmis, Nabil, Kobyliak, Nazarii, Koffas, Apostolos, Koike, Kazuhiko, Kok, Kenneth Y.Y., Koller, Tomas, Komas, Narcisse Patrice, Korochanskaya, Nataliya V., Koulla, Yannoula, Koya, Shunji, Kraft, Colleen, Kraja, Bledar, Krawczyk, Marcin, Kuchay, Mohammad Shafi, Kulkarni, Anand V, Kumar, Ashish, Kumar, Manoj, Lakoh, Sulaiman, Lam, Philip, Lan, Ling, Lange, Naomi F., Lankarani, Kamran Bagheri, Lanthier, Nicolas, Lapshyna, Kateryna, Lashen, Sameh A., Laure, Konang Nguieguia Justine, Lazebnik, Leonid, Lebrec, Didier, Lee, Samuel S., Lee, Way Seah, Lee, Yeong Yeh, Leeming, Diana Julie, Leite, Nathalie Carvalho, Leon, Roberto, Lesmana, Cosmas Rinaldi Adithya, Li, Junfeng, Li, Qiong, Li, Jun, Li, Yang-Yang, Li, Yufang, Li, Lei, Li, Min, li, Yiling, Liang, Huiqing, Lijuan, Tang, Lim, Seng Gee, Lim, Lee-Ling, Lin, Shumei, Lin, Han-Chieh, Lin, Rita, Lithy, Rania, Liu, Yaru, Liu, Yuanyuan, Liu, Xin, Liu, Wen-Yue, Liu, Shourong, Liu, Ken, Liu, Tian, Lonardo, Amedeo, López, Mariana Bravo, López-Benages, Eva, Lopez-Jaramillo, Patricio, Lu, Huimin, Lu, Lun Gen, Lu, Yan, Lubel, John, Lui, Rashid, Lupasco, Iulianna, Luzina, Elena, Lv, Xiao-Hui, Lynch, Kate, Ma, Hong-Lei, Machado, Mariana Verdelho, Maduka, Nonso, Madzharova, Katerina, Magdaong, Russellini, Mahadeva, Sanjiv, Mahfouz, Amel, Mahmood, Nik Ritza Kosai Nik, Mahmoud, Eman, Mahrous, Mohamed, Maiwall, Rakhi, Majeed, Ammar, Majumdar, Avik, Mak, Loey, Maklouf, Madiha M, Malekzadeh, Reza, Mandato, Claudia, Mangia, Alessandra, Mann, Jake, Mansour, Hala Hussien, Mansouri, Abdellah, Mantovani, Alessandro, Mao, Jun qian, Maramag, Flor, Marchesini, Giulio, Marcus, Claude, Marinho, Rui António Rocha Tato, Martinez-Chantar, Maria L, Martins, Antonieta A. Soares, Marwan, Rana, Mason, Karen Frances, Masoud, Ghadeer, Massoud, Mohamed Naguib, Matamoros, Maria Amalia, Mateos, Rosa Martín, Mawed, Asmaa, Mbanya, Jean Claude, Mbendi, Charles, McColaugh, Lone, McLeod, Duncan, Medina, Juan Francisco Rivera, Megahed, Ahmed, Mehrez, Mai, Memon, Iqbal, Merat, Shahin, Mercado, Randy, Mesbah, Ahmed, Meskini, Taoufik, Metwally, Mayada, Metwaly, Rasha, Miao, Lei, Micah, Eileen, Miele, Luca, Milivojevic, Vladimir, Milovanovic, Tamara, Mina, Yvonne L., Mishkovik, Milan, Mishriki, Amal, Mitchell, Tim, Mohamed, Alshaimaa, Mohamed, Mona, Mohamed, Sofain, Mohammed, Shady, Mohammed, Ahmed, Mohan, Viswanathan, Mohie, Sara, Mokhtar, Aalaa, Moniem, Reham, Montilla, Mabel Segura, Morales, Jose Antonio Orozco, Morata, María María Sánchez, Moreno-Planas, Jose Maria, Morise, Silvia, Mosaad, Sherif, Moselhy, Mohamed, Mostafa, Alaa Mohamed, Mostafa, Ebraheem, Mouane, Nezha, Mousa, Nasser, Moustafa, Hamdy Mahfouz, Msherif, Abeer, Muller, Kate, Munoz, Christopher, Muñoz-Urribarri, Ana Beatriz, Murillo, Omar Alfaro, Mustapha, Feisul Idzwan, Muzurović, Emir, Nabil, Yehia, Nafady, Shaymaa, Nagamatsu, Ayu, Nakajima, Atsushi, Nakano, Dan, Nan, Yuemin, Nascimbeni, Fabio, Naseef, Mirella S., Nashat, Nagwa, Natalia, Taran, Negro, Francesco, Nersesov, Alexander V., Neuman, Manuela, Ng'wanasayi, Masolwa, Ni, Yan, Nicoll, Amanda, Niizeki, Takashi, Nikolova, Dafina, Ningning, Wang, Niriella, Madunil, Nogoibaeva, K.A, Nordien, Rozeena, O Sullivan, Catherine, O'Beirne, James, Obekpa, Solomon, Ocama, Ponsiano, Ochwoto, Missiani, Ogolodom, Michael Promise, Ojo, Olusegun, Okrostsvaridze, Nana, Oliveira, Claudia P., Omaña, Raul Contreras, Omar, Omneya M., Omar, Hanaa, Omar, Mabroka, Omran, Salma, Omran, Reham, Osman, Marian Muse, Owise, Nevin, Owusu-Ansah, Theobald, Padilla- Machaca, P. Martín, Palle, Sirish, Pan, Ziyan, Pan, Xiao-Yan, Pan, Qiuwei, Papaefthymiou, Apostolis, Paquissi, Feliciano Chanana, Par, Gabriella, Parkash, Arit, Payawal, Diana, Peltekian, Kevork M., Peng, Xuebin, Peng, Liang, Peng, Ying, Pengoria, Rahul, Perez, Martina, Pérez, José Luis, Pérez, Norma Marlene, Persico, Marcello, Pessoa, Mário Guimarães, Petta, Salvatore, Philip, Mathew, Plaz Torres, Maria Corina, Polavarapu, Naveen, Poniachik, Jaime, Portincasa, Piero, Pu, Chunwen, Pürnak, Tuğrul, Purwanto, Edhie, Qi, Xiaolong, Qi, Xingshun, Qian, Zibing, Qiang, Zhao, Qiao, Zengpei, Qiao, Liang, Queiroz, Alberto, Rabiee, Atoosa, Radwan, Manal, Rahetilahy, Alain Marcel, Ramadan, Yasmin, Ramadan, Dina, Ramli, Anis Safura, Ramm, Grant A., Ran, Ao, Rankovic, Ivan, RAO, Huiying, Raouf, Sara, Ray, Sayantan, Reau, Nancy, Refaat, Ahmed, Reiberger, Thomas, Remes-Troche, Jose M, Reyes, Eira Cerda, Richardson, Ben, Ridruejo, Ezequiel, Riestra Jimenez, Sergio, Rizk, Ibrahim, Roberts, Stuart, Roblero, Juan Pablo, Robles, Jorge Alberto Prado, Rockey, Don, Rodríguez, Manuel, Rodríguez Hernández, Heriberto, Román, Eva, Romeiro, Fernando Gomes, Romeo, Stefano, Rosales-Zabal, Jose Miguel, Roshdi, Georgina R., Rosso, Natalia, Ruf, Andres, Ruiz, Patricia Cordero, Runes, Nelia R., Ruzzenente, Andrea, Ryan, Marno, Saad, Ahmed, Sabbagh, Eman BE, Sabbah, Meriam, Saber, Shimaa, Sabrey, Reham, Sabry, Ramy, Saeed, Maysaa Abdallah, Said, Dina, Said, Ebada M, Sakr, Mohammad Amin, Salah, Yara, Salama, Rabab Maamoun, Salama, Asmaa, Saleh, Hussein, Saleh, Ahmed, Salem, Ahmed, Salem, Ahmed Thabet, Salifou, Alkassoum, Salih, Aso Faeq, Salman, Abdallah, Samouda, Hanen, Sanai, Faisal, Sánchez-Ávila, Juan Francisco, Sanker, Lakshumanan, Sano, Tomoya, Sanz, Miquel, Saparbu, Tobokalova, Sawhney, Rohit, Sayed, Fatma, Sayed, Sayed A., Sayed, Ashraf Othman, Sayed, Manar, Sebastiani, Giada, Secadas, Laura, Sediqi, Khawaja Qamaruddin, Seif, Sameh, Semida, Nady, Şenateş, Ebubekir, Serban, Elena Daniela, Serfaty, Lawrence, Seto, Wai-Kay, Sghaier, Ikram, Sha, Min, Shabaan, Hamada M., Shalaby, Lobna, Shaltout, Inass, Sharara, Ala I., Sharma, Vishal, Shawa, Isaac Thom, Shawkat, Ahmed, Shawky, Nehal, Shehata, Osama, Sheils, Sinead, Shewaye, Abate Bane, Shi, Guojun, Shi, Junping, Shimose, Shigeo, Shirono, Tomotake, Shou, Lan, Shrestha, Ananta, Shui, Guanghou, Sievert, William, Sigurdardottir, Solveig, Sira, Mostafa Mohamed, Siradj, Riyadh, Sison, Cecilia, Smyth, Linda, Soliman, Reham, Sollano, Jose D, Sombie, Roger, Sonderup, Mark, Sood, Siddharth, Soriano, German, Stedman, Catherine A M, Stefanyuk, Oksana, Štimac, Davor, Strasser, Simone, Strnad, Pavel, Stuart, Katherine, Su, Wen, Su, Minghua, Sumida, Yoshio, Sumie, Shuji, Sun, Dan-Qin, Sun, Jing, Suzuki, Hiroyuki, Svegliati-Baroni, Gianluca, Swar, Mohamed Osman, TAHARBOUCHT, S., Taher, Zenab, Takamura, Saori, Tan, Lin, Tan, Soek-Siam, Tanwandee, Tawesak, Tarek, Sara, Tatiana, Ghelimici, Tavaglione, Federica, Tecson, Gina Y., Tee, Hoi-Poh, Teschke, 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Mohammed, Xia, Hongping, Xiao, Jian, Xiao, Xiao, Xiaofeng, Wang, Xiong, Wanyuan, Xu, Liang, Xu, Jie, Xu, Weiguo, Xu, Jing-Hang, Xu, Keshu, Xu, Yumin, Xu, Shi-Hao, Xu, Meng, Xu, Aimin, Xu, Chengfu, Yan, Hongmei, Yang, Jingyi, Yang, Rui-Xu, Yang, Yating, Yang, Qinhe, Yang, Naibin, Yao, Jia, Yara, Justine, Yaraş, Serkan, Yılmaz, Nimet, Younes, Ramy, younes, Huda, Young, Sona, Youssef, Farah, Yu, Yanyan, Yu, Ming-Lung, Yuan, Jing, Yue, Zhang, Yuen, Man-Fung, Yun, Wang, Yurukova, Nonka, Zakaria, Serag, Zaky, Samy, Zaldastanishvili, Maia, Zapata, Rodrigo, Zare, Nazanin, Zerem, Enver, Zeriban, Nema, Zeshuai, Xu, Zhang, Huijie, Zhang, Xuemei, Zhang, Yupei, Zhang, Wen-Hua, Zhang, Xuchen, Zhang, Yon-ping, Zhang, Yuexin, Zhang, Zhan-qing, Zhao, Jingmin, Zhao, Rong-Rong, Zhao, Hongwei, Zheng, Chao, Zheng, Yijie, Zheng, Ruidan, Zheng, Tian-Lei, Zheng, Kenneth, Zhou, Xi Qiao, Zhou, Yongjian, Zhou, Yu-Jie, Zhou, Hong, Zhou, Ling, Zhou, Yongning, Zhu, Long dong, Zhu, Yong Fen, Zhu, Yueyong, Zhu, Pei-Wu, Ziada, Ebtesam, Ziring, David, Ziyi, Li, Zou, Shanshan, Zou, Zhengsheng, Zou, Huaibin, Zuart Ruiz, Roberto, Méndez-Sánchez, Nahum, Bugianesi, Elisabetta, Gish, Robert G, Lammert, Frank, Tilg, Herbert, Nguyen, Mindie H, Sarin, Shiv K, Fabrellas, Núria, Zelber-Sagi, Shira, Fan, Jian-Gao, Shiha, Gamal, Targher, Giovanni, Zheng, Ming-Hua, Chan, Wah-Kheong, Vinker, Shlomo, Kawaguchi, Takumi, Castera, Laurent, Yilmaz, Yusuf, Korenjak, Marko, Spearman, C Wendy, Ungan, Mehmet, Palmer, Melissa, El-Shabrawi, Mortada, Gruss, Hans-Juergen, Dufour, Jean-François, Dhawan, Anil, Wedemeyer, Heiner, George, Jacob, Valenti, Luca, Fouad, Yasser, Romero‐Gomez, Manuel, and Eslam, Mohammed

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2022
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28. Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals

Author

Howe, Anita Y. M., Rodrigo, Chaturaka, Cunningham, Evan B., Douglas, Mark W., Dietz, Julia, Grebely, Jason, Popping, Stephanie, Sfalcin, Javier Alejandro, Parczewski, Milosz, Sarrazin, Christoph, de Salazar, Adolfo, Fuentes, Ana, Sayan, Murat, Quer, Josep, Kjellin, Midori, Kileng, Hege, Mor, Orna, Lennerstrand, Johan, Fourati, Slim, Di Maio, Velia Chiara, Chulanov, Vladimir, Pawlotsky, Jean-Michel, Harrigan, P. Richard, Ceccherini-Silberstein, Francesca, Garcia, Federico, Howe, Anita Y. M., Rodrigo, Chaturaka, Cunningham, Evan B., Douglas, Mark W., Dietz, Julia, Grebely, Jason, Popping, Stephanie, Sfalcin, Javier Alejandro, Parczewski, Milosz, Sarrazin, Christoph, de Salazar, Adolfo, Fuentes, Ana, Sayan, Murat, Quer, Josep, Kjellin, Midori, Kileng, Hege, Mor, Orna, Lennerstrand, Johan, Fourati, Slim, Di Maio, Velia Chiara, Chulanov, Vladimir, Pawlotsky, Jean-Michel, Harrigan, P. Richard, Ceccherini-Silberstein, Francesca, and Garcia, Federico

Abstract

Background & Aims: Direct-acting antiviral (DAA) regimens provide a cure in >95% of patients with chronic HCV infection. However, in some patients in whom therapy fails, resistance-associated substitutions (RASs) can develop, limiting retreatment options and risking onward resistant virus transmission. In this study, we evaluated RAS prevalence and distribution, including novel NS5A RASs and clinical factors associated with RAS selection, among patients who experienced DAA treatment failure. Methods: SHARED is an international consortium of clinicians and scientists studying HCV drug resistance. HCV sequence linked metadata from 3,355 patients were collected from 22 countries. NS3, NS5A, and NS5B RASs in virologic failures, including novel NS5A substitutions, were examined. Associations of clinical and demographic characteristics with RAS selection were investigated. Results: The frequency of RASs increased from its natural prevalence following DAA exposure: 37% to 60% in NS3, 29% to 80% in NS5A, 15% to 22% in NS5B for sofosbuvir, and 24% to 37% in NS5B for dasabuvir. Among 730 virologic failures, most were treated with first-generation DAAs, 94% had drug resistance in >-1 DAA class: 31% single-class resistance, 42% dual-class resistance (predominantly against protease and NS5A inhibitors), and 21% triple-class resistance. Distinct patterns containing >-2 highly resistant RASs were common. New potential NS5A RASs and adaptive changes were identified in genotypes 1a, 3, and 4. Following DAA failure, RAS selection was more frequent in older people with cirrhosis and those infected with genotypes 1b and 4. Conclusions: Drug resistance in HCV is frequent after DAA treatment failure. Previously unrecognized substitutions continue to emerge and remain uncharacterized.Lay summary: Although direct-acting antiviral medications effectively cure hepatitis C in most patients, sometimes treatment selects for resistant viruses, causing antiviral drugs to be either in

Published
2022
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29. Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals

Author

Howe, Anita Y.M., Rodrigo, Chaturaka, Cunningham, Evan B., Douglas, Mark W., Dietz, Julia, Grebely, Jason, Popping, Stephanie, Sfalcin, Javier Alejandro, Parczewski, Milosz, Sarrazin, Christoph, de Salazar, Adolfo, Fuentes, Ana, Sayan, Murat, Quer, Josep, Kjellin, Midori, Kileng, Hege, Mor, Orna, Lennerstrand, Johan, Fourati, Slim, Di Maio, Velia Chiara, Chulanov, Vladimir, Pawlotsky, Jean Michel, Harrigan, P. Richard, Ceccherini-Silberstein, Francesca, Garcia, Federico, Howe, Anita Y.M., Rodrigo, Chaturaka, Cunningham, Evan B., Douglas, Mark W., Dietz, Julia, Grebely, Jason, Popping, Stephanie, Sfalcin, Javier Alejandro, Parczewski, Milosz, Sarrazin, Christoph, de Salazar, Adolfo, Fuentes, Ana, Sayan, Murat, Quer, Josep, Kjellin, Midori, Kileng, Hege, Mor, Orna, Lennerstrand, Johan, Fourati, Slim, Di Maio, Velia Chiara, Chulanov, Vladimir, Pawlotsky, Jean Michel, Harrigan, P. Richard, Ceccherini-Silberstein, Francesca, and Garcia, Federico

Abstract

Background & Aims: Direct-acting antiviral (DAA) regimens provide a cure in >95% of patients with chronic HCV infection. However, in some patients in whom therapy fails, resistance-associated substitutions (RASs) can develop, limiting retreatment options and risking onward resistant virus transmission. In this study, we evaluated RAS prevalence and distribution, including novel NS5A RASs and clinical factors associated with RAS selection, among patients who experienced DAA treatment failure. Methods: SHARED is an international consortium of clinicians and scientists studying HCV drug resistance. HCV sequence linked metadata from 3,355 patients were collected from 22 countries. NS3, NS5A, and NS5B RASs in virologic failures, including novel NS5A substitutions, were examined. Associations of clinical and demographic characteristics with RAS selection were investigated. Results: The frequency of RASs increased from its natural prevalence following DAA exposure: 37% to 60% in NS3, 29% to 80% in NS5A, 15% to 22% in NS5B for sofosbuvir, and 24% to 37% in NS5B for dasabuvir. Among 730 virologic failures, most were treated with first-generation DAAs, 94% had drug resistance in ≥1 DAA class: 31% single-class resistance, 42% dual-class resistance (predominantly against protease and NS5A inhibitors), and 21% triple-class resistance. Distinct patterns containing ≥2 highly resistant RASs were common. New potential NS5A RASs and adaptive changes were identified in genotypes 1a, 3, and 4. Following DAA failure, RAS selection was more frequent in older people with cirrhosis and those infected with genotypes 1b and 4. Conclusions: Drug resistance in HCV is frequent after DAA treatment failure. Previously unrecognized substitutions continue to emerge and remain uncharacterized. Lay summary: Although direct-acting antiviral medications effectively cure hepatitis C in most patients, sometimes treatment selects for resistant viruses, causing antiviral drugs to be either ineffe

Published
2022

30. Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals

Author

Howe, Anita Y M, Rodrigo, Chaturaka, Cunningham, Evan B, Douglas, Mark W, et al, Müllhaupt, Beat; https://orcid.org/0000-0002-9020-8192, Howe, Anita Y M, Rodrigo, Chaturaka, Cunningham, Evan B, Douglas, Mark W, et al, and Müllhaupt, Beat; https://orcid.org/0000-0002-9020-8192

Abstract

BACKGROUND & AIMS Direct-acting antiviral (DAA) regimens provide a cure in >95% of patients with chronic HCV infection. However, in some patients in whom therapy fails, resistance-associated substitutions (RASs) can develop, limiting retreatment options and risking onward resistant virus transmission. In this study, we evaluated RAS prevalence and distribution, including novel NS5A RASs and clinical factors associated with RAS selection, among patients who experienced DAA treatment failure. METHODS SHARED is an international consortium of clinicians and scientists studying HCV drug resistance. HCV sequence linked metadata from 3,355 patients were collected from 22 countries. NS3, NS5A, and NS5B RASs in virologic failures, including novel NS5A substitutions, were examined. Associations of clinical and demographic characteristics with RAS selection were investigated. RESULTS The frequency of RASs increased from its natural prevalence following DAA exposure: 37% to 60% in NS3, 29% to 80% in NS5A, 15% to 22% in NS5B for sofosbuvir, and 24% to 37% in NS5B for dasabuvir. Among 730 virologic failures, most were treated with first-generation DAAs, 94% had drug resistance in ≥1 DAA class: 31% single-class resistance, 42% dual-class resistance (predominantly against protease and NS5A inhibitors), and 21% triple-class resistance. Distinct patterns containing ≥2 highly resistant RASs were common. New potential NS5A RASs and adaptive changes were identified in genotypes 1a, 3, and 4. Following DAA failure, RAS selection was more frequent in older people with cirrhosis and those infected with genotypes 1b and 4. CONCLUSIONS Drug resistance in HCV is frequent after DAA treatment failure. Previously unrecognized substitutions continue to emerge and remain uncharacterized. LAY SUMMARY Although direct-acting antiviral medications effectively cure hepatitis C in most patients, sometimes treatment selects for resistant viruses, causing antiviral drugs to be either ineffective or only p

Published
2022

31. Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals

Author

Howe, Anita Y.M., primary, Rodrigo, Chaturaka, additional, Cunningham, Evan B., additional, Douglas, Mark W., additional, Dietz, Julia, additional, Grebely, Jason, additional, Popping, Stephanie, additional, Sfalcin, Javier Alejandro, additional, Parczewski, Milosz, additional, Sarrazin, Christoph, additional, de Salazar, Adolfo, additional, Fuentes, Ana, additional, Sayan, Murat, additional, Quer, Josep, additional, Kjellin, Midori, additional, Kileng, Hege, additional, Mor, Orna, additional, Lennerstrand, Johan, additional, Fourati, Slim, additional, Di Maio, Velia Chiara, additional, Chulanov, Vladimir, additional, Pawlotsky, Jean-Michel, additional, Harrigan, P. Richard, additional, Ceccherini-Silberstein, Francesca, additional, Garcia, Federico, additional, Martinello, Marianne, additional, Matthews, Gail, additional, Fernando, Fay Fabián, additional, Esteban, Juan I., additional, Müllhaupt, Beat, additional, Wiesch, Julian Schulze zur, additional, Buggisch, Peter, additional, Neumann-Haefelin, Christoph, additional, Berg, Thomas, additional, Berg, Christoph P., additional, Schattenberg, Jörn M., additional, Moreno, Christophe, additional, Stauber, Rudolf, additional, Lloyd, Andrew, additional, Dore, Gregory, additional, Applegate, Tanya, additional, Ignacio, Juan, additional, Garcia-Cehic, Damir, additional, Gregori, Josep, additional, Rodriguez-Frias, Francisco, additional, Rando, Ariadna, additional, Gozlan, Yael, additional, Angelico, Mario, additional, Andreoni, Massimo, additional, Babudieri, Sergio, additional, Bertoli, Ada, additional, Cento, Valeria, additional, Coppola, Nicola, additional, Craxì, Antonio, additional, Paolucci, Stefania, additional, Parruti, Giustino, additional, Pasquazzi, Caterina, additional, Perno, Carlo Federico, additional, Teti, Elisabetta, additional, Vironet, C., additional, Lannergård, Anders, additional, Duberg, Ann-Sofi, additional, Aleman, Soo, additional, Gutteberg, Tore, additional, Soulier, Alexandre, additional, Gourgeon, Aurélie, additional, Chevaliez, Stephane, additional, Pol, Stanislas, additional, Carrat, Fabrice, additional, Salmon, Dominique, additional, Kaiser, Rolf, additional, Knopes, Elena, additional, Gomes, Perpetua, additional, de Kneght, Rob, additional, Rijnders, Bart, additional, Poljak, Mario, additional, Lunar, Maja, additional, Usubillaga, Rafael, additional, Seguin_Devaux, Carole, additional, Tay, Enoch, additional, Wilson, Caroline, additional, Wang, Dao Sen, additional, George, Jacob, additional, Kok, Jen, additional, Pérez, Ana Belén, additional, Chueca, Natalia, additional, García-Deltoro, Miguel, additional, Martínez-Sapiña, Ana María, additional, Lara-Pérez, María Magdalena, additional, García-Bujalance, Silvia, additional, Aldámiz-Echevarría, Teresa, additional, Vera-Méndez, Francisco Jesús, additional, Pineda, Juan Antonio, additional, Casado, Marta, additional, Pascasio, Juan Manuel, additional, Salmerón, Javier, additional, Alados-Arboledas, Juan Carlos, additional, Poyato, Antonio, additional, Téllez, Francisco, additional, Rivero-Juárez, Antonio, additional, Merino, Dolores, additional, Vivancos-Gallego, María Jesús, additional, Rosales-Zábal, José Miguel, additional, Ocete, María Dolores, additional, Simón, Miguel Ángel, additional, Rincón, Pilar, additional, Reus, Sergi, additional, De la Iglesia, Alberto, additional, García-Arata, Isabel, additional, Jiménez, Miguel, additional, Jiménez, Fernando, additional, Hernández-Quero, José, additional, Galera, Carlos, additional, Balghata, Mohamed Omar, additional, Primo, Joaquín, additional, Masiá, Mar, additional, Espinosa, Nuria, additional, Delgado, Marcial, additional, von-Wichmann, Miguel Ángel, additional, Collado, Antonio, additional, Santos, Jesús, additional, Mínguez, Carlos, additional, Díaz-Flores, Felícitas, additional, Fernández, Elisa, additional, Bernal, Enrique, additional, De Juan, José, additional, Antón, José Joaquín, additional, Vélez, Mónica, additional, Aguilera, Antonio, additional, Navarro, Daniel, additional, Arenas, Juan Ignacio, additional, Fernández, Clotilde, additional, Espinosa, María Dolores, additional, Ríos, María José, additional, Alonso, Roberto, additional, Hidalgo, Carmen, additional, Hernández, Rosario, additional, Téllez, María Jesús, additional, Rodríguez, Francisco Javier, additional, Antequera, Pedro, additional, Delgado, Cristina, additional, Martín, Patricia, additional, Crespo, Javier, additional, Becerril, Berta, additional, Pérez, Oscar, additional, García-Herola, Antonio, additional, Montero, José, additional, Freyre, Carolina, additional, Grau, Concepción, additional, Cabezas, Joaquin, additional, Jimenez, Miguel, additional, Rodriguez, Manuel Alberto Macias, additional, Quilez, Cristina, additional, Pardo, Maria Rodriguez, additional, Muñoz-Medina, Leopoldo, additional, and Figueruela, Blanca, additional

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2022
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32. Global multi-stakeholder endorsement of the MAFLD definition

Author

Méndez-Sánchez, Nahum, primary, Bugianesi, Elisabetta, additional, Gish, Robert G, additional, Lammert, Frank, additional, Tilg, Herbert, additional, Nguyen, Mindie H, additional, Sarin, Shiv K, additional, Fabrellas, Núria, additional, Zelber-Sagi, Shira, additional, Fan, Jian-Gao, additional, Shiha, Gamal, additional, Targher, Giovanni, additional, Zheng, Ming-Hua, additional, Chan, Wah-Kheong, additional, Vinker, Shlomo, additional, Kawaguchi, Takumi, additional, Castera, Laurent, additional, Yilmaz, Yusuf, additional, Korenjak, Marko, additional, Spearman, C Wendy, additional, Ungan, Mehmet, additional, Palmer, Melissa, additional, El-Shabrawi, Mortada, additional, Gruss, Hans-Juergen, additional, Dufour, Jean-François, additional, Dhawan, Anil, additional, Wedemeyer, Heiner, additional, George, Jacob, additional, Valenti, Luca, additional, Fouad, Yasser, additional, Romero‐Gomez, Manuel, additional, Eslam, Mohammed, additional, Abate, Maria Lorena, additional, Abbas, Bahaa, additional, Abbassy, Ahmed Amr, additional, Abd El Ghany, Waleed, additional, Abd Elkhalek, Amira, additional, Abd ElMajeed, Emad, additional, Abdalgaber, Mohammad, additional, AbdAllah, Mohamed, additional, Abdallah, Marwa, additional, Abdallah, Nourhan, additional, Abdelaleem, Shereen, additional, Abdelghani, Yasser, additional, Abdelghany, Wael, additional, Abdelhalim, Safaa Mohamed, additional, Abdelhamid, Wafaa, additional, Abdelhamid, Nehal, additional, Abdelkader, Nadia A., additional, Abdelkreem, Elsayed, additional, Abdelmohsen, Aly Mohamed, additional, Abdelrahman, Awny Ali, additional, Abd-elsalam, Sherief M, additional, Abdeltawab, Doaa, additional, Abduh, Abdulbaset, additional, Abdulhakam, Nada, additional, Abdulla, Maheeba, additional, Abedpoor, Navid, additional, Abenavoli, Ludovico, additional, Åberg, Fredrik, additional, Ablack, Omala, additional, Abo elftouh, Mostafa, additional, Abo-Amer, Yousry Esam-Eldin, additional, Aboubkr, Ashraf, additional, Aboud, Alaa, additional, Abouelnaga, Amr M., additional, Aboufarrag, Galal A., additional, Aboutaleb, Ashraf, additional, Abundis, Leticia, additional, Adalı, Gupse, additional, Adames, Enrique, additional, Adams, Leon, additional, Adda, Danjuma, additional, Adel, Noor, additional, Adel, Nada, additional, Adel Sayed, Muhammad, additional, Afaa, Taiba Jibril, additional, Afredj, Nawal, additional, Aghayeva, Gulnara, additional, Aghemo, Alessio, additional, Aguilar-Salinas, Carlos A., additional, Ahlenstiel, Golo, additional, Ahmady, Walid, additional, Ahmed, Wafaa, additional, Ahmed, Amira, additional, Ahmed, Samah Nasser, additional, Ahmed, Heba Mostafa, additional, Ahmed, Rasha, additional, Aigner, Elmar, additional, Akarsu, Mesut, additional, Akroush, Maisam, additional, Akyuz, Umit, additional, Al Mahtab, Mamun, additional, Al Qadiri, Tahani, additional, Al Rawahi, Yusriya, additional, AL rubaee, Razzaq, additional, Al Saffar, Muna, additional, Alam, Shahinul, additional, Al-Ani, Zaid, additional, Albillos, Agustín, additional, Alboraie, Mohamed, additional, Al-Busafi, Said, additional, Al-Emam, Mohamed, additional, Alharthi, Jawaher, additional, Ali, Kareem, additional, Ali, Basma Abdelmoez, additional, Ali, Mohammad, additional, Ali, Raja Affendi Raja, additional, Alisi, Anna, additional, AL-Khafaji, Ali Raad, additional, Alkhatry, Maryam, additional, Aller, Rocio, additional, Almansoury, Yahya, additional, Al-Naamani, Khalid, additional, Alnakeeb, Alaa, additional, Alonso, Anna, additional, Alqahtani, Saleh A., additional, Alrabadi, Leina, additional, Alswat, Khalid, additional, Altaher, Mahir, additional, Altamimi, Turki, additional, Altamirano, Jose, additional, Alvares-da-Silva, Mario R., additional, Aly, Elsragy Adel M., additional, Alzahaby, Amgad, additional, Alzamzamy, Ahmed, additional, Amano, Keisuke, additional, Amer, Maysa A., additional, Amin, Mona A., additional, Amin, Sayed A., additional, Amir, Ashraf A., additional, Ampuero, Javier, additional, Anas, Noha, additional, Andreone, Pietro, additional, Andriamandimby, Soa Fy, additional, Anees, Mahmoud, additional, Angela, Peltec, additional, Antonios, Manal, additional, Arafat, Wael, additional, Araya, Jose Moreno, additional, Armendariz-Borunda, Juan, additional, Armstrong, Matthew J., additional, Ashktorab, Hassan, additional, Aspichueta, Patricia, additional, Assal, Fathia, additional, Atef, Mira, additional, Attia, Dina, additional, Atwa, Hoda, additional, Awad, Reham, additional, Awad, Mohyeldeen Abd Elaziz, additional, Awny, Sally, additional, Awolowo, Obafemi, additional, Awuku, Yaw Asante, additional, Ayada, Ibrahim, additional, Aye, Than Than, additional, Ayman, Sherif, additional, Ayman, Hedy, additional, Ayoub, Hesham, additional, Azmy, Hosny M., additional, Babaran, Romiro P., additional, Badreldin, Omneya, additional, Badry, Ahmed, additional, Bahçecioğlu, İbrahim Halil, additional, Bahour, Amira, additional, Bai, Jiajia, additional, Balaban, Yasemin, additional, Balasubramanyam, Muthuswamy, additional, Bamakhrama, Khaled, additional, Banales, Jesus M, additional, Bangaru, Babu, additional, Bao, Jianfeng, additional, Barahona, Jorge Suazo, additional, Barakat, Salma, additional, Barbalho, Sandra Maria, additional, Barbra, Bikwa, additional, Barranco, Beatriz, additional, Barrera, Francisco, additional, Baumann, Ulrich, additional, Bazeed, Shamardan, additional, Bech, Eva, additional, Benayad, Aourarh, additional, Benesic, Andreas, additional, Bernstein, David, additional, Bessone, Fernando, additional, Birney, Susie, additional, Bisseye, Cyrille, additional, Blake, Martin, additional, Bobat, Bilal, additional, Bonfrate, Leonilde, additional, Bordin, Dmitry S, additional, Bosques-Padilla, Francisco, additional, Boursier, Jerome, additional, Boushab, Boushab Mohamed, additional, Bowen, David, additional, Bravo, Patricia Medina, additional, Brennan, Paul N, additional, Bright, Bisi, additional, Broekaert, Ilse, additional, Buque, Xabier, additional, Burgos-Santamaría, Diego, additional, Burman, Julio, additional, Busetto, Luca, additional, Byrne, Chris D., additional, Cabral-Prodigalidad, Patricia Anne I., additional, Cabrera-Alvarez, Guillermo, additional, Cai, Wei, additional, Cainelli, Francesca, additional, Caliskan, Ali Riza, additional, Canbay, Ali, additional, Cano-Contreras, Ana, additional, Cao, Hai-Xia, additional, Cao, Zhujun, additional, Carrion, Andres, additional, Carubbi, Francesca, additional, Casanovas, Teresa, additional, Castellanos Fernández, Marlen Ivón, additional, Chai, Jin, additional, Chan, Siew Pheng, additional, Charatcharoenwitthaya, Phunchai, additional, Chavez-Tapia, Norberto, additional, Chayama, Kazuaki, additional, Chen, Jinjun, additional, Chen, Lin, additional, Chen, Zhong-Wei, additional, Chen, Huiting, additional, Chen, Sui-Dan, additional, Chen, Qiang, additional, Chen, Yaxi, additional, Chen, Gang, additional, Chen, En-Quang, additional, Chen, Fei, additional, Chen, Pei-Jer, additional, Cheng, Robert, additional, Cheng, Wendy, additional, Chieh, Jack Tan Wei, additional, Chokr, Imad, additional, Cholongitas, Evangelos, additional, Choudhury, Ashok, additional, Chowdhury, Abhijit, additional, Chukwudike, Evaristus Sunday, additional, Ciardullo, Stefano, additional, Clayton, Michelle, additional, Clement, Karine, additional, Cloa, Marie Michelle, additional, Coccia, Cecilia, additional, Collazos, Cristina, additional, Colombo, Massimo, additional, Cosar, Arif Mansur, additional, Cotrim, Helma Pinchemel, additional, Couillerot, Joris, additional, Coulibaly, Alioune, additional, Crespo, Gonzalo, additional, Crespo, Javier, additional, Cruells, Maria, additional, Cua, Ian Homer Y., additional, Dabbous, Hesham K., additional, Dalekos, George N, additional, D'Alia, Patricia, additional, Dan, Li, additional, Dao, Viet Hang, additional, Darwish, Mostafa, additional, Datz, Christian, additional, Davalos-Moscol, Milagros B, additional, Dawoud, Heba, additional, de Careaga, Blanca Olaechea, additional, de Knegt, Robert, additional, de Ledinghen, Victor, additional, de Silva, Janaka, additional, Debzi, Nabil, additional, Decraecker, Marie, additional, Del Pozo, Elvira, additional, Delgado, Teresa C, additional, Delgado-Blanco, Manuel, additional, Dembiński, Łukasz, additional, Depina, Adilson, additional, Derbala, Moutaz, additional, Desalegn, Hailemichael, additional, Desbois-Mouthon, Christèle, additional, Desoky, Mahmoud, additional, Dev, Anouk, additional, Di Ciaula, Agostino, additional, Diago, Moisés, additional, Diallo, Ibrahima, additional, Díaz, Luis Antonio, additional, Dirchwolf, Melisa, additional, Dongiovanni, Paola, additional, Dorofeyev, Andrriy, additional, Dou, Xiaoguang, additional, Douglas, Mark W., additional, Doulberis, Michael, additional, Dovia, Cecil K., additional, Doyle, Adam, additional, Dragojević, Ivana, additional, Drenth, Joost PH, additional, Duan, Xuefei, additional, Dulskas, Audrius, additional, Dumitrascu, Dan L, additional, Duncan, Oliver, additional, Dusabejambo, Vincent, additional, Dwawhi, Rev. Shem N.A., additional, Eiketsu, Sho, additional, El Amrousy, Doaa, additional, El Deeb, Ahmed, additional, El Deriny, Ghada, additional, El Din, Hesham Salah, additional, El Kamshishy, Salwa, additional, El Kassas, Mohamed, additional, El Raziky, Maissa, additional, Elagamy, Osama A, additional, Elakel, Wafaa, additional, Elalfy, Dina, additional, Elaraby, Hanaa, additional, ElAwady, Heba, additional, Elbadawy, Reda, additional, Eldash, Hanaa Hassan, additional, Eldefrawy, Manal S., additional, Elecharri, Carol Lezama, additional, Elfaramawy, Amel, additional, Elfatih, Mohammed, additional, Elfiky, Mahmoud, additional, Elgamsy, Mohamed, additional, Elgendy, Mohamed, additional, El-Guindi, Mohamed A., additional, Elhussieny, Nagi, additional, Eliwa, Ahmed Maher, additional, Elkabbany, Zeineb, additional, El-Khayat, Hesham, additional, El-Koofy, Nehal M., additional, Elmetwalli, Alaa, additional, Elrabat, Amr, additional, El-Raey, Fathiya, additional, Elrashdy, Fatma, additional, Elsahhar, Medhat, additional, Elsaid, Esraa M., additional, Elsayed, Shimaa, additional, Elsayed, Hany, additional, Elsayed, Aly, additional, Elsayed, Amr M., additional, Elsayed, Hamdy, additional, El-Serafy, Magdy, additional, Elsharkawy, Ahmed M., additional, Elsheemy, Reem Yehia, additional, Elshemy, Eman Elsayed, additional, Elsherbini, Sara, additional, Eltoukhy, Naglaa, additional, Elwakil, Reda, additional, Emad, Ola, additional, Emad, Shaimaa, additional, Embabi, Mohamed, additional, Ergenç, Ilkay, additional, Ermolova, Tatiana, additional, Esmat, Gamal, additional, Esmat, Doaa M., additional, Estupiñan, Enrique Carrera, additional, Ettair, Said, additional, Eugen, Tcaciuc, additional, Ezz-Eldin, Mohammed, additional, Falcón, Lidia Patricia Valdivieso, additional, Fan, Yu-Chen, additional, Fandari, Samah, additional, Farag, Mahmoud, additional, Farahat, Taghreed Mohamed, additional, Fares, Eman M., additional, Fares, Michael, additional, Fassio, Eduardo, additional, Fathy, Hayam, additional, Fathy, Dina, additional, Fathy, Wael, additional, Fayed, Soheir, additional, Feng, Dan, additional, Feng, Gong, additional, Fernández-Bermejo, Miguel, additional, Ferreira, Cristina Targa, additional, Ferrer, Javier Díaz, additional, Forbes, Alastair, additional, Fouad, Rabab, additional, Fouad, Hanan M., additional, Frisch, Tove, additional, Fujii, Hideki, additional, Fukunaga, Shuhei, additional, Fukunishi, Shinya, additional, Fulya, Hacer, additional, Furuhashi, Masato, additional, Gaber, Yasmine, additional, Galang, Augusto Jose G., additional, Gallardo, Jacqueline Cordova, additional, Galloso, Rocío, additional, Gamal, Mahmoud, additional, Gamal, Reham, additional, Gamal, Hadeel, additional, Gan, Jian, additional, Ganbold, Anar, additional, Gao, Xin, additional, Garas, George, additional, Garba, Tony, additional, García-Cortes, Miren, additional, García-Monzón, Carmelo, additional, García-Samaniego, Javier, additional, Gastaldelli, Amalia, additional, Gatica, Manuel, additional, Gatley, Elizabeth, additional, Gegeshidze, Tamar, additional, Geng, Bin, additional, Ghazinyan, Hasmik, additional, Ghoneem, Salma, additional, Giacomelli, Luca, additional, Giannelli, Gianluigi, additional, Giannini, Edoardo G., additional, Giefer, Matthew, additional, Ginès, Pere, additional, Girala, Marcos, additional, Giraudi, Pablo J, additional, Goh, George Boon-Bee, additional, Gomaa, Ahmed Ali, additional, Gong, Benbingdi, additional, Gonzales, Dina Hilda C., additional, Gonzalez, Humberto C., additional, Gonzalez-Huezo, Maria Saraí, additional, Graupera, Isabel, additional, Grgurevic, Ivica, additional, Grønbæk, Henning, additional, Gu, Xuelian, additional, Guan, Lin, additional, Gueye, Ibrahima, additional, Guingané, Alice Nanelin, additional, Gul, Ozen Oz, additional, Gul, Cuma Bulent, additional, Guo, Qing, additional, Gupta, Pramendra Prasad, additional, Gurakar, Ahmet, additional, Gutierrez, Juan Carlos Restrepo, additional, Habib, Ghada, additional, Hafez, Azaa, additional, Hagman, Emilia, additional, Halawa, Eman, additional, Hamdy, Osama, additional, Hamed, Abd Elkhalek, additional, Hamed, Dina H., additional, Hamid, Saeed, additional, Hamoudi, Waseem, additional, Han, Yu, additional, Haridy, James, additional, Haridy, Hanan, additional, Harris, David C H Harris, additional, Hart, Michael, additional, Hasan, Fuad, additional, Hashim, Almoutaz, additional, Hassan, Israa, additional, Hassan, Ayman, additional, Hassan, Essam Ali, additional, Hassan, Adel Ahmed, additional, Hassan, Magda Shehata, additional, Hassanin, Fetouh, additional, Hassnine, Alshymaa, additional, Haukeland, John Willy, additional, Hawal, Amr Ismael M., additional, He, Jinfan, additional, He, Qiong, additional, He, Yong, additional, He, Fang-Ping, additional, Hegazy, Mona, additional, Hegazy, Adham, additional, Henegil, Osama, additional, Hernández, Nelia, additional, Hernández-Guerra, Manuel, additional, Higuera-de-la-Tijera, Fatima, additional, Hindy, 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Published
2022
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36. SHARED: An International Collaboration to Unravel Hepatitis C Resistance

Author

Howe, Anita Y.M., primary, Ceccherini-Silberstein, Francesca, additional, Dietz, Julia, additional, Popping, Stephanie, additional, Grebely, Jason, additional, Rodrigo, Chaturaka, additional, Lennerstrand, Johan, additional, Douglas, Mark W., additional, Parczewsk, Milosz, additional, Harrigan, P. Richard, additional, Pawlotsky, Jean-Michel, additional, Garcia, Federico, additional, and Collaborators, SHARED, additional

Published
2021
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38. SHARED : An International Collaboration to Unravel Hepatitis C Resistance

Author

Howe, Anita Y. M., Ceccherini-Silberstein, Francesca, Dietz, Julia, Popping, Stephanie, Grebely, Jason, Rodrigo, Chaturaka, Lennerstrand, Johan, Douglas, Mark W., Parczewsk, Milosz, Harrigan, P. Richard, Pawlotsky, Jean-Michel, Garcia, Federico, Howe, Anita Y. M., Ceccherini-Silberstein, Francesca, Dietz, Julia, Popping, Stephanie, Grebely, Jason, Rodrigo, Chaturaka, Lennerstrand, Johan, Douglas, Mark W., Parczewsk, Milosz, Harrigan, P. Richard, Pawlotsky, Jean-Michel, and Garcia, Federico

Published
2021
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39. SHARED: an international collaboration to unravel Hepatitis C resistance

Author

SHARED Collaborators, Howe, Anita Y. M., Ceccherini-Silberstein, Francesca, Dietz, Julia, Popping, Stephanie, Grebely, Jason, Rodrigo, Chaturaka, Lennerstrand, Johan, Douglas, Mark W., Parczewski, Milosz, Harrigan, P. Richard, Pawlotsky, Jean-Michel, Garcia, Federico, SHARED Collaborators, Howe, Anita Y. M., Ceccherini-Silberstein, Francesca, Dietz, Julia, Popping, Stephanie, Grebely, Jason, Rodrigo, Chaturaka, Lennerstrand, Johan, Douglas, Mark W., Parczewski, Milosz, Harrigan, P. Richard, Pawlotsky, Jean-Michel, and Garcia, Federico

Published
2021

40. Targeting liver metabolism: a pathway to cure hepatitis B virus?

Author

Ajoyan, Harout, Douglas, Mark W, and Tu, Thomas

Subjects
HEPATITIS B virus, HEPATITIS B vaccines, FATTY acid synthases, FARNESOID X receptor, HEPATITIS C virus, METABOLISM
Abstract

• This paper reviews studies targeting host metabolism to treat hepatitis C virus, providing proof of principle for this approach to antiviral therapy 2 Liaw YF, Kao JH, Piratvisuth T, et al. For hepatitis B virus (HBV, an incurable and common blood-borne infection), treatments targeting metabolic pathways remain relatively under-explored. For example, the treatment of HepG2.2.15 cells that stably express HBV with deoxynojirimycin (a small-molecule inhibitor of -glucosidase) led to significant degradation of medium HBV surface protein by 86% as well as large HBV surface protein by 56% [[15]]. [Extracted from the article]

Published
2023
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45. The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23

Author

Diefenbach, Russell J., Diefenbach, Eve, Douglas, Mark W., and Cunningham, Anthony L.

Subjects
Biochemistry -- Research, Carrier proteins -- Physiological aspects, Kinesin -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on kinesin molecular motor proteins' cargo binding domain. The study of the possible cargo proteins which may bind to the kinesin domain has been carried out via the use of yeast two-hybrid assay and the results are reported.

Published
2002

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