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1. Diagnostic uncertainty presented barriers to the timely management of acute thrombotic thrombocytopenic purpura in the United Kingdom between 2014 and 2019

Author

Bull, Tom P., McCulloch, Rory, Nicolson, Phillip L.R., Doyle, Andrew J., Shaw, Rebecca J., Langridge, Alexander, Sayar, Zara, Tucker, David L., Pettit, Michala, Perry, Rita, Thomas, William, Page, Catherine, Whalley, Ioana, Dutt, Tina, Garth, Louise, Lester, Will, Buka, Richard J., Subhan, Mary, Ware, Victoria, Rayment, Rachel, Castle, Daniel, Etherington, Astrid, Carter‐Brzezinski, Luke, Peters, Jayne, Corrigan, Claire, Sharma, Narind, Benson, Gary, Challenor, Sarah, Skinner, Thomas S., Zhao, Rui, McLeod‐Kennedy, Lyndsay A.G., Douglas, Kenneth, Knott, Amy, Smith, Sophie, Wolf, Julia, Todd, Sophie A., McDonald, Vickie, Rampotas, Alexandros, Dean, Christopher, Sangha, Gavinda, Pavord, Sue, Denny, Nicholas, Jaafar, Sarah, McLaughlin, David P.T., Ross, Jennifer E., Karanth, Mamatha, Beverstock, Sarah L., Mansonso, Lynn, Burrows, Samuel H., Tauro, Sudhir, Shenouda, Amir, Bailiff, Benjamin M., Kajita, Daniel, Hermans, Joannes, Goradia, Harshita, Finan, Emily M., Alford, Sarah, Pickard, Keir, Greystoke, Brigit, Fail, Thomas, Abdussalam, Asmaa, Roberts, Lara N, Clark, James B., Heeney, Natalie, Young, Jennifer, Maddox, Jamie, Srinath, Swathy, Khawaja, Jahanzeb, Parkes, Jayne, Babiker, Samah, Hunt, Beverley J., Wheeldon, Sarah L., Kerr, Paul, Tahhan, Molham, Vickers, Mark, Pike, Alexandra C., Hill, Quentin, Mustafa, Nadreen, Almaremi, Azza, Hughes, Emily, McGoldrick, Sean J.F., Loizou, Eleana, James, Izabela, Boyce, Sara R., Farmer, Isabel, Thanigaikumar, Murugaiyan, Wickenden, Katherine, Gooding, Richard, Thornton, Kathryn, Kane, Clare, Cole, Adam, Griffin, JessicaC, Docherty, Suzanne, Dixon, Kiri I., Crowe, Josephine, Sheridan, Mathew, De Lord, Corinne, Sud, Amit, Austin, Anna, Coooper, Nichola, Bailey, Chris, Attwell, Luke, Hall, Rachel, Gray, Benjamin, Chauhan, Salena R., Lokare, Anand, Gudger, Amy, Horgan, Claire, Venkatadasari, Indrani, Kaddam, Israa, Mapplebeck, Claire L., Van Veen, Joost, Raj, Maya, De Abrew, Kanchana, Belsham, Edward, Gyansah, Cecilia, Sadullah, Shalal, Salhan, Beena, Murrin, Richard, Williams, Rhys L., Stewart, Andrew, Cornish, Naomi, Otton, Sophie, Khan, Zeeshan, Ackroyd, Sam, Chen, Lucia Y., Lafferty, Nicholas P., Leonforte, Francesca, Pemberton, Nicholas, Rawi, Emanal, Triantafyllopoulou, Diana, Adiyodi, Jagdish, Yong, Jun, Jones, Elizabeth, Davies, David, Peck, Rachel C., Philip, Robson, Seddon, Thomas, Cahalin, Paul, Prodger, Catherine, Dutton, David A., Sternberg, Alexander J., Chengal, Rajani, Polzella, Paolo, and Scully, Marie

Published
2022
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3. Effect of Extended Release Steroid Implants on the Contralateral Eye

Author

Efrat Fleissig and Douglas Kenneth Sigford

Subjects
CST, Central subfield thickness, Macular Volume, Intravitreal extended release steroid injection, Contralateral eye, Dexamethasone intravitreal implant (Ozurdex), Ophthalmology, RE1-994
Abstract

Abstract Purpose To investigate the contralateral effect of extended release steroid implants on cystoid macular edema (CME). Methods Retrospective study of patients with bilateral CME receiving intravitreal injections of long-acting intravitreal corticosteroid implants in one eye. Changes in CME and central subfield thickness (CST) in the contralateral eye on optical coherence tomography (OCT) were compared to an untreated control group. The main outcome measures were the change in central subfield thickness (CST) and the change in the macular volume. Results Thirteen study patients and 14 controls were included in the study. There was no difference in the baseline LogMAR visual acuity (0.32 ± 0.35 vs 0.43 ± 0.26, p = 0.37) or the baseline central subfield thickness (341.4 ± 76.6 vs 296.5 ± 65.0 µm, p = 0.12) between groups. In the treatment group CST remained stable in 92.3% of the patients. Of the controls, CST worsened in 21.4% and remained stable in 78.6%. The mean change in CST (6.3 ± 30.3 vs. 27.5 ± 66.1 µm, p = 0.2) and the mean change in macular volume (0.08 ± 0.34 vs. -0.05 ± 0.21 mm3, P = 0.8) were not statistically different between the treatment group and control group. In the post-hoc analysis restricting the treatment group to patients who had not received intravitreal injections in the study eye within 6 months, CST decrement was not statistically significant (p = 0.11). Conclusion In this study there was no statistically significant effect on CME of contralateral intravitreal corticosteroid implants.

Published
2022
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17. Bilateral neuroretinits and exudative retinal detachment with multifocal subretinal deposits secondary to Bartonella henselae infection

Author

Efrat Fleissig, Fiona Kim, Douglas Kenneth Sigford, and Charles C. Barr

Subjects
Neuroretinitis, Retinal detachment, Bartonella henselae, Subretinal deposits, Ophthalmology, RE1-994
Abstract

Purpose: to describe a case of bilateral neuroretinitis with bullous retinal detachment and multiple subretinal lesions, in a 10-year-old immunocompetent girl. Observations: A broad workup for infectious, inflammatory and masquerade etiologies was done for the patient, resulting in positive IgM and IgG for Bartonella henselae. The patient demonstrated improvement in the visual acuity, and rapid resolution of the retinal detachment and subretinal lesions in both eyes in response to systemic rifampin, doxycycline and corticosteroids. Conclusions and Importance: Bartonella henselae neuroretinitis may present as an acute form of bullous retinal detachment with multiple subretinal lesions and markedly reduced vision. Significant visual improvement may occur with prompt treatment with a combination of systemic antibiotics and corticosteroids.

Published
2021
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18. Education in the Peterborough Diocese in the century following the "Glorious Revolution", 1688

Author

Shearing, Douglas Kenneth

Subjects
900, Humanities and Social Sciences
Abstract

There is a consensus of academic opinion that for approximately 100 years stretching from 1688, the date of the 'Glorious Revolution', to the onset of industrialisation England enjoyed relative stability, the condition being attributed to political pragmatism. The purpose of this thesis is twofold; to document the educational developments that characterized the period and to examine their effect, nature and scope, about which historians sharply disagree. The principle that in any age education is a social tool whose practical possibilities rest on people's assumptions determined the strategy of pursuing four main lines of enquiry. These form thematic chapters, the contents of which are briefly summarized as follows: 1. Provision; the Church of England's supervisory role; incidental management of schools. 2. The curriculum and teaching methodology employed in the various scholastic institutions. 3. A survey of scholars in attendance at elementary schools, grammar schools and academies. 4. A consideration of the teaching force with sections on religious attitudes, financial standing and professionalism. Although the study has a national dimension its distinct regional focus is intentional because the bulk of surviving records relate to a locality, enabling its educational system to be largely reconstructed. The Peterborough diocese proved to be an eminently suitable choice being both the setting for educational diversity and extremely rich in source material. The evidence which accrued was not used merely to illustrate what is already known; rather, it made possible more realistic interpretations of the macro situation than hitherto. It is argued in the conclusion that education neither stagnated nor regressed. The principal finding is that the classical tradition of the grammar schools and the universities gradually lost ground to Dissent with its insistence on science and 'the relief of man's estate'. Consequently, new ideas were enterprisingly translated into commendable practice.

Published
1990

20. UK consensus statement on the use of plerixafor to facilitate autologous peripheral blood stem cell collection to support high‐dose chemoradiotherapy for patients with malignancy

Author

Douglas, Kenneth W., Gilleece, Maria, Hayden, Patrick, Hunter, Hannah, Johnson, Peter R. E., Kallmeyer, Charlotte, Malladi, Ram K., Paneesha, Shankara, Pawson, Rachel, Quinn, Michael, Raj, Kavita, Richardson, Deborah, Robinson, Stephen, Russell, Nigel, Snowden, John, Sureda, Anna, Tholouli, Eleni, Thomson, Kirsty, Watts, Mike, and Wilson, Keith M.

Published
2018
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23. Effect of Extended Release Steroid Implants on the Contralateral Eye

Author

Efrat Fleissig and Douglas Kenneth Sigford

Subjects
Ophthalmology, Visual Acuity, Humans, Steroids, General Medicine, Macular Edema, Tomography, Optical Coherence, Retrospective Studies
Abstract

Purpose To investigate the contralateral effect of extended release steroid implants on cystoid macular edema (CME). Methods Retrospective study of patients with bilateral CME receiving intravitreal injections of long-acting intravitreal corticosteroid implants in one eye. Changes in CME and central subfield thickness (CST) in the contralateral eye on optical coherence tomography (OCT) were compared to an untreated control group. The main outcome measures were the change in central subfield thickness (CST) and the change in the macular volume. Results Thirteen study patients and 14 controls were included in the study. There was no difference in the baseline LogMAR visual acuity (0.32 ± 0.35 vs 0.43 ± 0.26, p = 0.37) or the baseline central subfield thickness (341.4 ± 76.6 vs 296.5 ± 65.0 µm, p = 0.12) between groups. In the treatment group CST remained stable in 92.3% of the patients. Of the controls, CST worsened in 21.4% and remained stable in 78.6%. The mean change in CST (6.3 ± 30.3 vs. 27.5 ± 66.1 µm, p = 0.2) and the mean change in macular volume (0.08 ± 0.34 vs. -0.05 ± 0.21 mm3, P = 0.8) were not statistically different between the treatment group and control group. In the post-hoc analysis restricting the treatment group to patients who had not received intravitreal injections in the study eye within 6 months, CST decrement was not statistically significant (p = 0.11). Conclusion In this study there was no statistically significant effect on CME of contralateral intravitreal corticosteroid implants.

Published
2021

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