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26 results on '"Douen, Andre"'

1. Time Course of Early Hematoma Expansion in Acute Spot-Sign Positive Intracerebral Hemorrhage: Prespecified Analysis of the SPOTLIGHT Randomized Clinical Trial

Author

Al-Ajlan, Fahad S., Gladstone, David J., Song, Dongbeom, Thorpe, Kevin E., Swartz, Rick H., Butcher, Kenneth S., del Campo, Martin, Dowlatshahi, Dar, Gensicke, Henrik, Lee, Gloria Jooyoung, Flaherty, Matthew L., Hill, Michael D., Aviv, Richard I., Demchuk, Andrew M., Swartz, Richard H., Gladstone, David J., Boyle, Karl, Braganza, Maria, Fedasko, Nadia, Golob, Dolores, Bardi, Edith, Senyshyn, Samantha, Cayley, Megan, Colavecchia, Connie, Demchuk, Andrew M., Hill, Michael D., Coutts, Shelagh, Klein, Gary, Menon, Bijoy, Watson, Tim, Smith, Eric, Subramaniam, Suresh, Bal, Simerpreet, Barber, Philip, Camden, Marie-Christine, Horton, Myles, Mishra, Sachin, Nambiar, Vivek, Torres, Andres Venegas, Adatia, Sweta, Alseraya, Amjad, Desai, Jamsheed, Mandzia, Jennifer, Shamy, Michel, Trivedi, Anurag, Choi, Philip, Dubuc, Veronique, Klourfeld, Evgenia, Field, Thalia, Singh, Dilip, Musuka, Tapuwa, Bloujney, Sarah, Nikneshan, Davar, Imoukhuede, Oje, Yu, Amy, Appireddy, Ramana, Evans, Jamie, Ryckborst, Karla, Calvert, Carly, Dowlatshahi, Dariush, Stotts, Grant, Sharma, Mukul, Robert, Sohail, Mortensen, Melodie, Shamloul, Rany, Campo, Martin Del, Silver, Frank L., Casaubon, Leanne, Jaigobin, Cheryl, Perez, Yael, Kalman, Libby, Abraham, Jemini, Wiegner, Relu, Cayley, Anne, Riediger, Victoria, Butcher, Ken, Kate, Mahesh, Jeerakathil, Thomas, Shuaib, Ashfaq, Gaucher, Sylvia, Sivakumar, Leka, Yip, Samuel, Teal, Philip, Woolfenden, Andrew, Benavente, Oscar, Beckman, Jeff, Murphy, Colleen, Field, Thalia, Asdaghi, Negar, Villaluna-MurrVay, Karina, Sahlas, Demetrios J., Algird, Almunder, Knapman, Jordan, Macmillan, Sue, Sancan, Janice, Mehdiratta, Manu, Perez, Yael, John, Verity, Dhanani, AlNoor, Temple, Bryan, Douen, Andre, Selchen, Daniel, Saposnik, Gustavo, Kostyrko, Pawel, Chan, Richard, Young, Bryan, Kumar, Balagopal, Soros, Peter, Hesser, Kimberley, Wright, Mary, Frank, Connie, Amato-Marziali, Belinda, Deschaintre, Yan, Poppe, Alexandre, Lapierre, Marlene, Boulanger, Jean-Martin, Berger, Leo, Blais, Lise, Simard, Christel, Teitelbaum, Jeanne, Campbell, Natasha, Jin, Al, Breen, Adriana, and Bickford, Suzanne

Published
2023
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7. Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor

Author

Weaver, Joel G.R., Tarze, Agathe, Moffat, Tia C., LeBras, Morgane, Deniaud, Aurelien, Brenner, Catherine, Bren, Gary D., Morin, Mario Y., Phenix, Barbara N., Dong, Li, Jiang, Susan X., Sim, Valerie L., Zurakowski, Bogdan, Lallier, Jessica, Hardin, Heather, Wettstein, Peter, van Heeswijk, Rolf P.G., Douen, Andre, Kroemer, Romano T., Hou, Sheng T., Bennett, Steffany A.L., Lynch, David H., Kroemer, Guido, and Badley, Andrew D.

Published
2005

21. The Role of Insulin Receptor Sulphydryl Groups in Insulin Binding and Cellular Response in Rat Adipocytes

Author

Douen, Andre and Jones, Malcolm

Abstract

Phenylarsine oxide (PAO), an agent which reacts with vicinal sulphydryl groups and dithiothreitol (DTT), a disulphide reducing agent, inhibited insulin binding to intact adipocytes with half maximal inhibition occuring at 28μM and 340μM, respectively. Pretreatment of adipocytes with DTT (2mM) prevented insulin stimulation of glucose uptake by approximately 50%. The marked inhibition of insulin binding to adipocytes by PAO and DTT is consistent with the involvement of the receptor cysteine-rich region of hormone binding. Furthermore, DTT inhibition of insulin binding suggests that the integrity of disulphide bridges is critical for insulin binding. The inhibitory effect of DTT and PAO on insulin binding were not additive, instead addition of DTT to PAO-treated adipocytes effected 15% reversal of binding inhibition. The marked inhibition of insulin binding by addition of low concentrations of DTT (0.2-2.0mM) to intact adipocytes is in contrast to the previously reported biphasic response for the effect of DTT on insulin binding to isolated plasma membranes from rat adipocytes (Schweitzer et al. Proc. Natl. Acad. Sci. U.S.A. 77, 4692-4696, 1980). Scatchard plots for 125I-iodoinsulin binding to adipocytes in the basal state were linear. In contrast, Scatchard analysis of insulin binding to plasma membranes prepared from both basal and insulin-stimulated adipocytes yielded severely curvilinear plots. The data suggests that (i) fundamental differences exist between the receptor state in intact cells and isolated plasma membranes and (ii) that a disulphide-rich region within the insulin receptor, other than the previously reported class I and class II disulphide bridges, is critical for insulin binding and cellular response.

Published
1990
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22. Insulin‐induced decrease in 5′‐nucleotidase activity in skeletal muscle membranes

Author

Klip, Amira, Ramlal, Toolsie, Douen, Andre G., Burdett, Elena, Young, Douglas, Cartee, Gregory D., and Holloszy, John O.

Abstract

Insulin releases inositol phosphoglycans from myocytes in culture [(1986) Science 233, 967–972], which display insulinomimetic activity. Because 5′‐nucleotidase is anchored to the membrane through inositol‐containing phospholipid glycans, we investigated whether insulin could release the enzyme from the membrane. Membranes prepared from hindquarter muscles of rats perfused with insulin showed a 23% decrease in 5′‐nucleotidase activity. Isolated membranes from muscle exposed to insulin in vitro also showed a small but reproducible decrease (9%) in 5′‐nucleotidase activity relative to unexposed controls. Phospholipase C from Staphylococcus aureusreleased 60% of the membrane‐bound 5′‐nucleotidase. We propose that insulin may activate an endogenous phospholipase C that cleaves phospholipid‐glycan‐anchored proteins.

Published
1988
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