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13 results on '"Dou, Yuanyan"'

2. Associations of inflammation related prenatal adversities with neurodevelopment of offspring in one year: a longitudinal prospective birth cohort study

Author

Gan, Ming, Zhu, Xianxian, Wang, Weiting, Ye, Kan, Jiang, Yangqian, Jiang, Tao, Lv, Hong, Lu, Qun, Qin, Rui, Tao, Shiyao, Huang, Lei, Xu, Xin, Liu, Cong, Dou, Yuanyan, Ke, Kang, Sun, Tianyu, Liu, Yuxin, Jiang, Yue, Han, Xiumei, Jin, Guangfu, Ma, Hongxia, Shen, Hongbing, Hu, Zhibin, Guan, Yichun, Lin, Yuan, and Du, Jiangbo

Published
2024
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5. Association of Breastfeeding and Neonatal Jaundice With Infant Neurodevelopment

Author

Ke, Kang, primary, Chi, Xia, additional, Lv, Hong, additional, Zhao, Jing, additional, Jiang, Yangqian, additional, Jiang, Tao, additional, Lu, Qun, additional, Qiu, Yun, additional, Tao, Shiyao, additional, Qin, Rui, additional, Huang, Lei, additional, Xu, Xin, additional, Liu, Cong, additional, Dou, Yuanyan, additional, Huang, Bo, additional, Xu, Bo, additional, Ma, Hongxia, additional, Jin, Guangfu, additional, Shen, Hongbing, additional, Hu, Zhibin, additional, Lin, Yuan, additional, and Du, Jiangbo, additional

Published
2023
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6. Association between prenatal exposure to trace elements mixture and visual acuity in infants: A prospective birth cohort study

Author

Wang, Zijin, primary, Dou, Yuanyan, additional, Guo, Wenhui, additional, Lin, Yuan, additional, Jiang, Yangqian, additional, Jiang, Tao, additional, Qin, Rui, additional, Lv, Hong, additional, Lu, Qun, additional, Jin, Guangfu, additional, Ma, Hongxia, additional, Hu, Zhibin, additional, Liu, Hu, additional, and Du, Jiangbo, additional

Published
2023
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7. Maternal exposure to metal mixtures during early pregnancy and fetal growth in the Jiangsu Birth Cohort, China

Author

Dou, Yuanyan, primary, Yin, Yin, additional, Li, Zhi, additional, Du, Jiangbo, additional, Jiang, Yangqian, additional, Jiang, Tao, additional, Guo, Wenhui, additional, Qin, Rui, additional, Li, Mei, additional, Lv, Hong, additional, Lu, Qun, additional, Qiu, Yun, additional, Lin, Yuan, additional, Jin, Guangfu, additional, Lu, Chuncheng, additional, Ma, Hongxia, additional, and Hu, Zhibin, additional

Published
2022
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8. Maternal Exposure to Metal Mixtures During Early Pregnancy and Fetal Growth in a Prospective Cohort Study

Author

Ma, Hongxia, primary, Dou, Yuanyan, additional, Yin, Yin, additional, Li, Zhi, additional, Du, Jiangbo, additional, Jiang, Yangqian, additional, Jiang, Tao, additional, Guo, Wenhui, additional, Qin, Rui, additional, Li, Mei, additional, Lv, Hong, additional, Lu, Qun, additional, Qiu, Yun, additional, Lin, Yuan, additional, Jin, Guangfu, additional, Lu, Chuncheng, additional, and Hu, Zhibin, additional

Published
2022
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10. Mechanisms underlying melatonin-mediated prevention of fenvalerate-induced behavioral and oxidative toxicity in zebrafish

Author

Guo Yichen, Han Wang, Fenju Qin, Yan An, Jian Tong, Dou Yuanyan, Jie Zhang, Cheng Ji, Rui Yan, Shasha Tao, Jihua Nie, Han Jingjing, Chen Ji, Ting Hong, and Wei Xiao

Subjects
Insecticides, Embryo, Nonmammalian, Neurogenesis, Health, Toxicology and Mutagenesis, Apoptosis, Oxidative phosphorylation, 010501 environmental sciences, Pharmacology, Protective Agents, Toxicology, 01 natural sciences, Melatonin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Nitriles, Pyrethrins, medicine, Animals, Zebrafish, Swimming, 0105 earth and related environmental sciences, Fenvalerate, Regulation of gene expression, biology, Water pollutants, Gene Expression Regulation, Developmental, Pesticide, biology.organism_classification, Oxidative Stress, chemistry, Toxicity, Water Pollutants, Chemical, 030217 neurology & neurosurgery, medicine.drug
Abstract

The neurotoxic effects attributed to the pesticide fenvalerate (FEN) are well-established. The aim of this study was to determine whether melatonin (MLT) was able to protect against FEN-induced behavior, oxidative stress, apoptosis, and neurogenesis using zebrafish (Danio rerio) model. Zebrafish exposed to 100 μg/L FEN for 120 h exhibited decreased swimming activity accompanied by downregulated expression of neurogenesis-related genes (Dlx2, Shha, Ngn1, Elavl3, and Gfap), suggesting that neurogenesis were impaired. In addition, FEN exposure significantly elevated oxidative stress as evidenced by increased malondialdehyde levels, as well as activities of Cu/Zn superoxide dismutase (Cu/Zn SOD), catalase, and glutathione peroxidase. Acridine orange staining demonstrated that embryos treated with FEN for 120 h significantly enhanced apoptosis mainly in the brain. FEN also produced upregulation of the expression of the pro-apoptotic genes (Bax, Fas, caspase 8, caspase 9, and caspase 3) and decreased expression of the anti-apoptotic gene Bcl-2. MLT significantly attenuated the FEN-mediated oxidative stress, modulated apoptotic-regulating genes, and diminished apoptotic responses. Further, MLT blocked the FEN-induced effects on swimming behavior as well as on neurogenesis-related genes. In conclusion, MLT protected against FEN-induced developmental neurotoxicity and apoptosis by inhibiting pesticide-mediated oxidative stress in zebrafish.

Published
2017
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12. Mechanisms underlying melatonin-mediated prevention of fenvalerate-induced behavioral and oxidative toxicity in zebrafish

Author

Han, Jingjing, primary, Ji, Cheng, additional, Guo, Yichen, additional, Yan, Rui, additional, Hong, Ting, additional, Dou, Yuanyan, additional, An, Yan, additional, Tao, Shasha, additional, Qin, Fenju, additional, Nie, Jihua, additional, Ji, Chen, additional, Wang, Han, additional, Tong, Jian, additional, Xiao, Wei, additional, and Zhang, Jie, additional

Published
2017
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13. Prenatal Parental Exposure to Metals and Birth Defects: A Prospective Birth Cohort Study

Author

Lv, Hong, Jiang, Yangqian, Ye, Kan, Wang, Jinghan, Wang, Weiting, Du, Jiangbo, Hu, Lingmin, Guo, Wenhui, Qin, Rui, Xu, Xin, Dou, Yuanyan, Sun, Tianyu, Liu, Xiaoyu, Xu, Bo, Han, Xiumei, Zhou, Kun, Tao, Shiyao, Lu, Qun, Jiang, Tao, Zhao, Yang, Jin, Guangfu, Ma, Hongxia, Xia, Yankai, Li, Jiong, Shen, Hongbing, Chi, Xia, Lin, Yuan, Hu, Zhibin, and Group, Jiangsu Birth Cohort (JBC) Study

Abstract

While maternal exposure to high metal levels during pregnancy is an established risk factor for birth defects, the role of paternal exposure remains largely unknown. We aimed to assess the associations of prenatal paternal and maternal metal exposure and parental coexposure with birth defects in singletons. This study conducted within the Jiangsu Birth Cohort recruited couples in early pregnancy. We measured their urinary concentrations for 25 metals. A total of 1675 parent–offspring trios were included. The prevalence of any birth defects among infants by one year of age was 7.82%. Paternal-specific gravity-corrected urinary concentrations of titanium, vanadium, chromium, manganese, cobalt, nickel, copper, and selenium and maternal vanadium, chromium, nickel, copper, selenium, and antimony were associated with a 21–91% increased risk of birth defects after adjusting for covariates. These effects persisted after mutual adjustment for the spouse’s exposure. Notably, when assessing the parental mixture effect by Bayesian kernel machine regression, paternal and maternal chromium exposure ranked the highest in relative importance. Parental coexposure to metal mixture showed a pronounced joint effect on the risk of overall birth defects, as well as for some specific subtypes. Our findings suggested a couple-based prevention strategy for metal exposure to reduce birth defects in offspring.

Published
2024
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