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4. Prolonged antibiotic prophylaxis in tissue reconstruction using autologous fat grafting: is there a benefit for wound healing?

Author

Morandi, Evi M., Winkelmann, Selina, Dostal, Lucie, Radacki, Isabel, Rieger, Ulrich, Bauer, Benedikt, Verstappen, Ralph, Wolfram, Dolores, Bauer, Thomas, Morandi, Evi M., Winkelmann, Selina, Dostal, Lucie, Radacki, Isabel, Rieger, Ulrich, Bauer, Benedikt, Verstappen, Ralph, Wolfram, Dolores, and Bauer, Thomas

Abstract

Fat grafting is a well-established method in plastic surgery. Despite many technical advances, standardised recommendations for the use of prophylactic antibiotics in fat grafting are not available. This retrospective multicentre study aims to analyse the use of prophylactic antibiotics in fat grafting and to compare complication rates for different protocols. A retrospective medical chart review of 340 patients treated with fat grafting of the breast from January 2007 to March 2019 was performed in three plastic surgery centres. Complications, outcomes, and antibiotic regimes were analysed. The Clavien-Dindo classification was applied. All patients received perioperative antibiotic prophylaxis: 33.8% (n = 115) were treated with a single shot (group 1), 66.2% (n = 225) received a prolonged antibiotic scheme (group 2). There was no significant difference in the number of sessions (P = .475). The overall complication rate was 21.6% (n = 75), including graft resorption, fat necrosis, infection, and wound healing problems. Complication rates were not significantly different between groups. Risk factors for elevated complication rates in this specific patient group are smoking, chemotherapy, and irradiation therapy. The complication rate for lipografting of the breast is low, and it is not correlated to the antibiotic protocol. The use of prolonged prophylactic antibiotics does not lower the complication rate.

Published
2021

5. Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC)

Author

Campa, Daniele, Claus, Rainer, Dostal, Lucie, Stein, Angelika, Chang-Claude, Jenny, Meidtner, Karina, Boeing, Heiner, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rodríguez, Laudina, Bonet, Catalina, Sánchez, Maria-José, Amiano, Pilar, Huerta, José María, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas, Travis, Ruth C., Allen, Naomi E., Trichopoulou, Antonia, Bamia, Christina, Benetou, Vassiliki, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, van Kranen, Henk, Bas Bueno-de-Mesquita, H., Peeters, Petra H. M., van Gils, Carla H., Lenner, Per, Sund, Malin, Lund, Eiliv, Gram, Inger Torhild, Rinaldi, Sabina, Chajes, Veronique, Romieu, Isabelle, Engel, Pierre, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Françoise, Siddiq, Afshan, Riboli, Elio, Canzian, Federico, and Kaaks, Rudolf

Published
2011
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7. Sector Irradiation vs. Whole Brain Irradiation After Resection of Singular Brain Metastasis—A Prospective Randomized Monocentric Trial

Author

Kerschbaumer, Johannes, primary, Pinggera, Daniel, additional, Holzner, Bernhard, additional, Delazer, Margarete, additional, Bodner, Thomas, additional, Karner, Elfriede, additional, Dostal, Lucie, additional, Kvitsaridze, Irma, additional, Minasch, Danijela, additional, Thomé, Claudius, additional, Seiz-Rosenhagen, Marcel, additional, Nevinny-Stickel, Meinhard, additional, and Freyschlag, Christian F., additional

Published
2020
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8. Prolonged antibiotic prophylaxis in tissue reconstruction using autologous fat grafting: Is there a benefit for wound healing?

Author

Morandi, Evi M., Winkelmann, Selina, Dostal, Lucie, Radacki, Isabel, Rieger, Ulrich M., Bauer, Benedikt, Verstappen, Ralph, Wolfram, Dolores, and Bauer, Thomas

Subjects
BREAST surgery, RESEARCH, PERIOPERATIVE care, WOUND healing, ACQUISITION of data methodology, PLASTIC surgery, RETROSPECTIVE studies, MEDICAL cooperation, SURGICAL complications, ANTIBIOTIC prophylaxis, AUTOGRAFTS, INFECTION, MEDICAL records, DESCRIPTIVE statistics, FAT, NECROSIS
Abstract

Fat grafting is a well‐established method in plastic surgery. Despite many technical advances, standardised recommendations for the use of prophylactic antibiotics in fat grafting are not available. This retrospective multicentre study aims to analyse the use of prophylactic antibiotics in fat grafting and to compare complication rates for different protocols. A retrospective medical chart review of 340 patients treated with fat grafting of the breast from January 2007 to March 2019 was performed in three plastic surgery centres. Complications, outcomes, and antibiotic regimes were analysed. The Clavien‐Dindo classification was applied. All patients received perioperative antibiotic prophylaxis: 33.8% (n = 115) were treated with a single shot (group 1), 66.2% (n = 225) received a prolonged antibiotic scheme (group 2). There was no significant difference in the number of sessions (P =.475). The overall complication rate was 21.6% (n = 75), including graft resorption, fat necrosis, infection, and wound healing problems. Complication rates were not significantly different between groups. Risk factors for elevated complication rates in this specific patient group are smoking, chemotherapy, and irradiation therapy. The complication rate for lipografting of the breast is low, and it is not correlated to the antibiotic protocol. The use of prolonged prophylactic antibiotics does not lower the complication rate. [ABSTRACT FROM AUTHOR]

Published
2022
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9. N-Acetyltransferase 2 Polymorphisms, Tobacco Smoking, and Breast Cancer Risk in the Breast and Prostate Cancer Cohort Consortium

Author

Cox, David G., Dostal, Lucie, Hunter, David J., Le Marchand, Loïc, Hoover, Robert, Ziegler, Regina G., Thun, Michael J., Diver, W. Ryan, Stevens, Victoria L., Amiano, Pilar, Boutron-Rualt, Marie-Christine, Campa, Daniele, van Duijnhoven, Fränzel J. B., Gram, Inger T., Kaaks, Rudolf, Khaw, Kay-Tee, Riboli, Elio, Sund, Malin, Trichopoulos, Demitrios, Tumino, Rosario, Vogel, Ulla, Kraft, Peter, Buring, Julie E., Hankinson, Susan E., Lee, I-Min, Zhang, Shumin M., Lindstrom, Sara, Berg, Christine D., Chanock, Stephen, Isaacs, Claudine, McCarty, Catherine, Haiman, Christopher A., and Henderson, Brian E.

Published
2011
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10. Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium

Author

Campa, Daniele, Kaaks, Rudolf, Le Marchand, Loïc, Haiman, Christopher A., Travis, Ruth C., Berg, Christine D., Buring, Julie E., Chanock, Stephen J., Diver, W. Ryan, Dostal, Lucie, Fournier, Agnes, Hankinson, Susan E., Henderson, Brian E., Hoover, Robert N., Isaacs, Claudine, Johansson, Mattias, Kolonel, Laurence N., Kraft, Peter, Lee, I-Min, McCarty, Catherine A., Overvad, Kim, Panico, Salvatore, Peeters, Petra H.M., Riboli, Elio, Sanchez, Maria José, Schumacher, Fredrick R., Skeie, Guri, Stram, Daniel O., Thun, Michael J., Trichopoulos, Dimitrios, Zhang, Shumin, Ziegler, Regina G., Hunter, David J., Lindström, Sara, and Canzian, Federico

Published
2011
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11. A Retrospective Propensity Score Matched Analysis Reveals Superiority of Hypothermic Machine Perfusion over Static Cold Storage in Deceased Donor Kidney Transplantation

Author

Gasteiger, Silvia, primary, Berchtold, Valeria, additional, Bösmüller, Claudia, additional, Dostal, Lucie, additional, Ulmer, Hanno, additional, Bogensperger, Christina, additional, Resch, Thomas, additional, Rudnicki, Michael, additional, Neuwirt, Hannes, additional, Oberhuber, Rupert, additional, Cardini, Benno, additional, Scheidl, Stefan, additional, Mayer, Gert, additional, Öfner, Dietmar, additional, Weissenbacher, Annemarie, additional, and Schneeberger, Stefan, additional

Published
2020
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13. Genetic Variability of the mTOR Pathway and Prostate Cancer Risk in the European Prospective Investigation on Cancer (EPIC)

Author

Campa, Daniele Huesing, Anika Stein, Angelika Dostal, Lucie and Boeing, Heiner Pischon, Tobias Tjonneland, Anne Roswall, Nina Overvad, Kim Ostergaard, Jane Nautrup Rodriguez, Laudina Sala, Nuria Sanchez, Maria-Jose Larranaga, Nerea and Maria Huerta, Jose Barricarte, Aurelio Khaw, Kay-Tee and Wareham, Nicholas Travis, Ruth C. Allen, Naomi E. Lagiou, Pagona Trichopoulou, Antonia Trichopoulos, Dimitrios Palli, Domenico Sieri, Sabina Tumino, Rosario Sacerdote, Carlotta and van Kranen, Henk Bueno-de-Mesquita, H. Bas Hallmans, Goran and Johansson, Mattias Romieu, Isabelle Jenab, Mazda Cox, David G. Siddiq, Afshan Riboli, Elio Canzian, Federico and Kaaks, Rudolf

Abstract

The mTOR (mammalian target of rapamycin) signal transduction pathway integrates various signals, regulating ribosome biogenesis and protein synthesis as a function of available energy and amino acids, and assuring an appropriate coupling of cellular proliferation with increases in cell size. In addition, recent evidence has pointed to an interplay between the mTOR and p53 pathways. We investigated the genetic variability of 67 key genes in the mTOR pathway and in genes of the p53 pathway which interact with mTOR. We tested the association of 1,084 tagging SNPs with prostate cancer risk in a study of 815 prostate cancer cases and 1,266 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). We chose the SNPs (n = 11) with the strongest association with risk (p

Published
2011

14. Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer

Author

Campa, Daniele Huesing, Anika Dostal, Lucie Stein, Angelika and Drogan, Dagmar Boeing, Heiner Tjonneland, Anne Roswall, Nina Ostergaard, Jane Nautrup Overvad, Kim Rodriguez, Laudina Bonet, Catalina Sanchez, Maria-Jose Larranaga, Nerea and Maria Huerta, Jose Ardanaz, Eva Khaw, Kay-Tee Wareham, Nicholas Travis, Ruth C. Allen, Naomi E. Trichopoulou, Antonia Zylis, Dimosthenis Karapetyan, Tina Palli, Domenico and Sieri, Sabina Tumino, Rosario Vineis, Paolo and Bueno-De-Mesquita, H. Bas Lenner, Per Johansson, Mattias and Jenab, Mazda Cox, David Siddiq, Afshan Kaaks, Rudolf and Canzian, Federico

Abstract

Forkhead box O3 (FOXO3) has a wide range of functions: it promotes tumor suppression, cell cycle arrest, repair of damaged DNA, detoxification of reactive oxygen species, apoptosis and plays a pivotal role in promoting longevity. FOXO3 is a key downstream target of the PI3K-Akt pathway in response to cellular stimulation by growth factors or insulin and has been proposed as a bridge between ageing and tumor suppression. Three SNPs in the FOXO3 gene (rs3800231, rs9400239 and rs479744) that have been shown to be strongly and consistently associated with longevity, were examined in relation to PC risk in a case control study of 1571 incident PC cases and 1840 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). There was no statistically significant association between the SNPs and PC risk regardless of the model of inheritance (dominant, codominant and recessive). The associations were not modified by disease aggressiveness, circulating levels of steroid sex hormones, or IGFs or BMI. We conclude that polymorphisms in the FOXO3 gene that are associated with longevity are not major risk factors for PC risk, in this population of Caucasian men.

Published
2011

15. Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)

Author

Campa, Daniele Huesing, Anika Chang-Claude, Jenny Dostal, Lucie Boeing, Heiner Kroeger, Janine Tjonneland, Anne and Roswall, Nina Overvad, Kim Dahm, Christina C. Rodriguez, Laudina Sala, Nuria Sanchez Perez, Maria Jose Larranaga, Nerea Chirlaque, Maria-Dolores Ardanaz, Eva Khaw, Kay-Tee and Wareham, Nick Allen, Naomi E. Travis, Ruth C. and Trichopoulou, Antonia Naska, Androniki Bamia, Christina and Palli, Domenico Sieri, Sabina Tumino, Rosario Sacerdote, Carlotta van Kranen, Henk J. Bueno-de-Mesquita, H. Bas and Stattin, Par Johansson, Mattias Chajes, Veronique Rinaldi, Sabina Romieu, Isabelle Siddiq, Afshan Norat, Teresa and Riboli, Elio Kaaks, Rudolf Canzian, Federico

Abstract

A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes belonging to the fatty acid synthesis pathway is related to prostate cancer risk in 815 prostate cancer cases and 1266 controls from the European Prospective Investigation on Cancer (EPIC). Using a tagging approach and selecting 252 SNPs in 22 genes, we covered all the common genetic variation of this pathway. None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk. (C) 2010 Elsevier Ltd. All rights reserved.

Published
2011

16. Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer

Author

Campa, Daniele, Huesing, Anika, Dostal, Lucie, Stein, Angelika, Drogan, Dagmar, Boeing, Heiner, Tjonneland, Anne, Roswall, Nina, Ostergaard, Jane Nautrup, Overvad, Kim, Rodriguez, Laudina, Bonet, Catalina, Sanchez, Maria-Jose, Larranaga, Nerea, Maria Huerta, Jose, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nicholas, Travis, Ruth C., Allen, Naomi E., Trichopoulou, Antonia, Zylis, Dimosthenis, Karapetyan, Tina, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Vineis, Paolo, Bueno-De-Mesquita, H. Bas, Lenner, Per, Johansson, Mattias, Jenab, Mazda, Cox, David, Siddiq, Afshan, Kaaks, Rudolf, Canzian, Federico, Campa, Daniele, Huesing, Anika, Dostal, Lucie, Stein, Angelika, Drogan, Dagmar, Boeing, Heiner, Tjonneland, Anne, Roswall, Nina, Ostergaard, Jane Nautrup, Overvad, Kim, Rodriguez, Laudina, Bonet, Catalina, Sanchez, Maria-Jose, Larranaga, Nerea, Maria Huerta, Jose, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nicholas, Travis, Ruth C., Allen, Naomi E., Trichopoulou, Antonia, Zylis, Dimosthenis, Karapetyan, Tina, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Vineis, Paolo, Bueno-De-Mesquita, H. Bas, Lenner, Per, Johansson, Mattias, Jenab, Mazda, Cox, David, Siddiq, Afshan, Kaaks, Rudolf, and Canzian, Federico

Abstract

Forkhead box O3 (FOXO3) has a wide range of functions: it promotes tumor suppression, cell cycle arrest, repair of damaged DNA, detoxification of reactive oxygen species, apoptosis and plays a pivotal role in promoting longevity. FOXO3 is a key downstream target of the PI3K-Akt pathway in response to cellular stimulation by growth factors or insulin and has been proposed as a bridge between ageing and tumor suppression. Three SNPs in the FOXO3 gene (rs3800231, rs9400239 and rs479744) that have been shown to be strongly and consistently associated with longevity, were examined in relation to PC risk in a case control study of 1571 incident PC cases and 1840 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). There was no statistically significant association between the SNPs and PC risk regardless of the model of inheritance (dominant, codominant and recessive). The associations were not modified by disease aggressiveness, circulating levels of steroid sex hormones, or IGFs or BMI. We conclude that polymorphisms in the FOXO3 gene that are associated with longevity are not major risk factors for PC risk, in this population of Caucasian men.

Published
2011
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17. Genetic variability of the mTOR pathway and prostate cancer risk in the European prospective investigation on cancer (EPIC)

Author

Campa, Daniele, Hüsing, Anika, Stein, Angelika, Dostal, Lucie, Boeing, Heiner, Pischon, Tobias, Tjønneland, Anne, Roswall, Nina, Overvad, Kim, Ostergaard, Jane Nautrup, Rodríguez, Laudina, Sala, Núria, Sánchez, Maria-José, Larrañaga, Nerea, Huerta, José María, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas, Travis, Ruth C, Allen, Naomi E, Lagiou, Pagona, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, van Kranen, Henk, Bueno-de-Mesquita, H Bas, Hallmans, Göran, Johansson, Mattias, Romieu, Isabelle, Jenab, Mazda, Cox, David G, Siddiq, Afshan, Riboli, Elio, Canzian, Federico, Kaaks, Rudolf, Campa, Daniele, Hüsing, Anika, Stein, Angelika, Dostal, Lucie, Boeing, Heiner, Pischon, Tobias, Tjønneland, Anne, Roswall, Nina, Overvad, Kim, Ostergaard, Jane Nautrup, Rodríguez, Laudina, Sala, Núria, Sánchez, Maria-José, Larrañaga, Nerea, Huerta, José María, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas, Travis, Ruth C, Allen, Naomi E, Lagiou, Pagona, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, van Kranen, Henk, Bueno-de-Mesquita, H Bas, Hallmans, Göran, Johansson, Mattias, Romieu, Isabelle, Jenab, Mazda, Cox, David G, Siddiq, Afshan, Riboli, Elio, Canzian, Federico, and Kaaks, Rudolf

Abstract

The mTOR (mammalian target of rapamycin) signal transduction pathway integrates various signals, regulating ribosome biogenesis and protein synthesis as a function of available energy and amino acids, and assuring an appropriate coupling of cellular proliferation with increases in cell size. In addition, recent evidence has pointed to an interplay between the mTOR and p53 pathways. We investigated the genetic variability of 67 key genes in the mTOR pathway and in genes of the p53 pathway which interact with mTOR. We tested the association of 1,084 tagging SNPs with prostate cancer risk in a study of 815 prostate cancer cases and 1,266 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). We chose the SNPs (n = 11) with the strongest association with risk (p<0.01) and sought to replicate their association in an additional series of 838 prostate cancer cases and 943 controls from EPIC. In the joint analysis of first and second phase two SNPs of the PRKCI gene showed an association with risk of prostate cancer (OR(allele) = 0.85, 95% CI 0.78-0.94, p = 1.3×10(-3) for rs546950 and OR(allele) = 0.84, 95% CI 0.76-0.93, p = 5.6×10(-4) for rs4955720). We confirmed this in a meta-analysis using as replication set the data from the second phase of our study jointly with the first phase of the Cancer Genetic Markers of Susceptibility (CGEMS) project. In conclusion, we found an association with prostate cancer risk for two SNPs belonging to PRKCI, a gene which is frequently overexpressed in various neoplasms, including prostate cancer.

Published
2011
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18. Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)

Author

Campa, Daniele, Hüsing, Anika, Chang-Claude, Jenny, Dostal, Lucie, Boeing, Heiner, Kröger, Janine, Tjønneland, Anne, Roswall, Nina, Overvad, Kim, Dahm, Christina C, Rodríguez, Laudina, Sala, Núria, Pérez, Maria José Sánchez, Larrañaga, Nerea, Chirlaque, Maria-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E, Travis, Ruth C, Trichopoulou, Antonia, Naska, Androniki, Bamia, Christina, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, van Kranen, Henk J, Bas Bueno-de-Mesquita, H, Stattin, Pär, Johansson, Mattias, Chajes, Veronique, Rinaldi, Sabina, Romieu, Isabelle, Siddiq, Afshan, Norat, Teresa, Riboli, Elio, Kaaks, Rudolf, Canzian, Federico, Campa, Daniele, Hüsing, Anika, Chang-Claude, Jenny, Dostal, Lucie, Boeing, Heiner, Kröger, Janine, Tjønneland, Anne, Roswall, Nina, Overvad, Kim, Dahm, Christina C, Rodríguez, Laudina, Sala, Núria, Pérez, Maria José Sánchez, Larrañaga, Nerea, Chirlaque, Maria-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E, Travis, Ruth C, Trichopoulou, Antonia, Naska, Androniki, Bamia, Christina, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, van Kranen, Henk J, Bas Bueno-de-Mesquita, H, Stattin, Pär, Johansson, Mattias, Chajes, Veronique, Rinaldi, Sabina, Romieu, Isabelle, Siddiq, Afshan, Norat, Teresa, Riboli, Elio, Kaaks, Rudolf, and Canzian, Federico

Abstract

A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes belonging to the fatty acid synthesis pathway is related to prostate cancer risk in 815 prostate cancer cases and 1266 controls from the European Prospective Investigation on Cancer (EPIC). Using a tagging approach and selecting 252 SNPs in 22 genes, we covered all the common genetic variation of this pathway. None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk.

Published
2011
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19. Genetic Variability of the mTOR Pathway and Prostate Cancer Risk in the European Prospective Investigation on Cancer (EPIC)

Author

Campa, Daniele, primary, Hüsing, Anika, additional, Stein, Angelika, additional, Dostal, Lucie, additional, Boeing, Heiner, additional, Pischon, Tobias, additional, Tjønneland, Anne, additional, Roswall, Nina, additional, Overvad, Kim, additional, Østergaard, Jane Nautrup, additional, Rodríguez, Laudina, additional, Sala, Núria, additional, Sánchez, Maria-José, additional, Larrañaga, Nerea, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Khaw, Kay-Tee, additional, Wareham, Nicholas, additional, Travis, Ruth C., additional, Allen, Naomi E., additional, Lagiou, Pagona, additional, Trichopoulou, Antonia, additional, Trichopoulos, Dimitrios, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, van Kranen, Henk, additional, Bueno-de-Mesquita, H. Bas, additional, Hallmans, Göran, additional, Johansson, Mattias, additional, Romieu, Isabelle, additional, Jenab, Mazda, additional, Cox, David G., additional, Siddiq, Afshan, additional, Riboli, Elio, additional, Canzian, Federico, additional, and Kaaks, Rudolf, additional

Published
2011
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20. Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)

Author

Campa, Daniele, primary, Hüsing, Anika, additional, Chang-Claude, Jenny, additional, Dostal, Lucie, additional, Boeing, Heiner, additional, Kröger, Janine, additional, Tjønneland, Anne, additional, Roswall, Nina, additional, Overvad, Kim, additional, Dahm, Christina C., additional, Rodríguez, Laudina, additional, Sala, Núria, additional, Pérez, Maria José Sánchez, additional, Larrañaga, Nerea, additional, Chirlaque, Maria-Dolores, additional, Ardanaz, Eva, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Allen, Naomi E., additional, Travis, Ruth C., additional, Trichopoulou, Antonia, additional, Naska, Androniki, additional, Bamia, Christina, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, van Kranen, Henk J., additional, Bas Bueno-de-Mesquita, H., additional, Stattin, Pär, additional, Johansson, Mattias, additional, Chajes, Veronique, additional, Rinaldi, Sabina, additional, Romieu, Isabelle, additional, Siddiq, Afshan, additional, Norat, Teresa, additional, Riboli, Elio, additional, Kaaks, Rudolf, additional, and Canzian, Federico, additional

Published
2011
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21. Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC)

Author

Campa, Daniele, primary, Claus, Rainer, additional, Dostal, Lucie, additional, Stein, Angelika, additional, Chang-Claude, Jenny, additional, Meidtner, Karina, additional, Boeing, Heiner, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Rodríguez, Laudina, additional, Bonet, Catalina, additional, Sánchez, Maria-José, additional, Amiano, Pilar, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Khaw, Kay-Tee, additional, Wareham, Nicholas, additional, Travis, Ruth C., additional, Allen, Naomi E., additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Benetou, Vassiliki, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, van Kranen, Henk, additional, Bas Bueno-de-Mesquita, H., additional, Peeters, Petra H. M., additional, van Gils, Carla H., additional, Lenner, Per, additional, Sund, Malin, additional, Lund, Eiliv, additional, Gram, Inger Torhild, additional, Rinaldi, Sabina, additional, Chajes, Veronique, additional, Romieu, Isabelle, additional, Engel, Pierre, additional, Boutron-Ruault, Marie Christine, additional, Clavel-Chapelon, Françoise, additional, Siddiq, Afshan, additional, Riboli, Elio, additional, Canzian, Federico, additional, and Kaaks, Rudolf, additional

Published
2010
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23. Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)

Author

Laudina Rodríguez, Anika Hüsing, Isabelle Romieu, Rudolf Kaaks, Naomi E. Allen, Heiner Boeing, Federico Canzian, Carlotta Sacerdote, Kim Overvad, Núria Sala, David G. Cox, Elio Riboli, José María Huerta, Henk J. van Kranen, Lucie Dostal, H. Bas Bueno-de-Mesquita, Jane Nautrup Østergaard, Afshan Siddiq, Ruth C. Travis, María José Sánchez, Nerea Larrañaga, Anne Tjønneland, Angelika Stein, Göran Hallmans, Nicholas J. Wareham, Daniele Campa, Antonia Trichopoulou, Nina Roswall, Rosario Tumino, Pagona Lagiou, Mazda Jenab, Dimitrios Trichopoulos, Aurelio Barricarte, Mattias Johansson, Kay-Tee Khaw, Domenico Palli, Tobias Pischon, Sabina Sieri, [Campa, Daniele, Huesing, Anika, Stein, Angelika, Dostal, Lucie, Canzian, Federico, Kaaks, Rudolf] German Canc Res Ctr, Heidelberg, Germany. [Boeing, Heiner, Pischon, Tobias] Deutsch Inst Ernahrungsforsch, Dept Epidemiol, Potsdam, Germany. [Tjonneland, Anne, Roswall, Nina] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Overvad, Kim, Ostergaard, Jane Nautrup] Aarhus Univ Hosp, Dept Cardiol, Cardiovasc Res Ctr, Aalborg Hosp, Aalborg, Denmark. [Overvad, Kim, Ostergaard, Jane Nautrup] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, DK-8000 Aarhus C, Denmark. [Rodriguez, Laudina] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain. [Sala, Nuria] ICO IDIBELL, Barcelona, Spain. [Sanchez, Maria-Jose] Andalusian Sch Publ Hlth, Granada, Spain. [Sanchez, Maria-Jose, Larranaga, Nerea, Maria Huerta, Jose, Barricarte, Aurelio] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain. [Larranaga, Nerea] Basque Govt, Publ Hlth Dept Gipuzkoa, Gipuzkoa, Spain. [Maria Huerta, Jose] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain. [Barricarte, Aurelio] Navarre Publ Hlth Inst, Pamplona, Spain. [Khaw, Kay-Tee] Univ Cambridge, Sch Clin Med, Cambridge, England. [Wareham, Nicholas] MRC Epidemiol Unit, Cambridge, England. [Travis, Ruth C., Allen, Naomi E.] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England. [Lagiou, Pagona, Trichopoulou, Antonia] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece. [Lagiou, Pagona, Trichopoulos, Dimitrios] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Trichopoulou, Antonia] Hellen Hlth Fdn, Athens, Greece. [Trichopoulos, Dimitrios] Acad Athens, Bur Epidemiol Res, Athens, Greece. [Palli, Domenico] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy. [Sieri, Sabina] Fdn IRCCS Ist Nazl Tumori, Milan, Italy. [Tumino, Rosario] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy. [Tumino, Rosario] Civile MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy. [Sacerdote, Carlotta] Ctr Canc Prevent CPO Piemonte, Turin, Italy. [Sacerdote, Carlotta] Human Genet Fdn HuGeF, Turin, Italy. [van Kranen, Henk, Bueno-de-Mesquita, H. Bas] Natl Inst Publ Hlth & Environm, Ctr Nutr & Hlth CVG, Bilthoven, Netherlands. [Hallmans, Goran, Johansson, Mattias] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden. [Johansson, Mattias, Romieu, Isabelle, Jenab, Mazda] Int Agcy Res Canc, F-69372 Lyon, France. [Cox, David G., Siddiq, Afshan, Riboli, Elio] Univ London Imperial Coll Sci Technol & Med, London, England. [Cox, David G.] Ctr Leon Berard, INSERM, F-69373 Lyon, France., Specific results of this study were obtained with financial support from the US Army Medical Research and Material Command (W81XWH-05-1-0156). http://cdmrp.army.mil/pcrp/default.shtml. The EPIC study was funded by 'Europe Against Cancer' Programme of the European Commission (SANCO), Ligue contre le Cancer (France), Société 3M (France), Mutuelle Générale de l'Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM), German Cancer Aid, German Cancer Research Center, German Federal Ministry of Education and Research, Danish Cancer Society, Health Research Fund (FIS) of the Spanish Ministry of Health, the participating regional governments and institutions of Spain, Cancer Research UK, Medical Research Council, UK, Hellenic Ministry of Health and Social Solidarity, the Stavros Niarchos Foundation and the Hellenic Health Foundation, Italian Association for Research on Cancer, Italian National Research Council, Dutch Ministry of Public Health, Welfare and Sports (VWS), Dutch Ministry of Health, Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) (The Netherlands), Statistics Netherlands, Swedish Cancer Society, Swedish Scientific Council, Regional Government of Skane, Sweden, Norwegian Cancer Society, Department of Cancer Epidemiology, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), German Institute of Human Nutrition Potsdam-Rehbrücke, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Cancer Epidemiology Institute, Department of Cardiology, Aarhus University Hospital, Public Health and Participation Directorate, Health and Health Care Services Council, Catalan Institute of Oncology, Consorcio de Investigación Biomédica en Red especializado en Epidemiología y Salud Pública (CIBERESP), Los Centros de Investigación Biomédica en Red (CIBER), Granada Cancer Registry, Andalusian School of Public Health [Granada], Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), CIBER de Epidemiología y Salud Pública (CIBERESP), Murcia Regional Health Authority, Public Health Institute of Navarra, School of Clinical Medicine, University of Cambridge [UK] (CAM), Epidemiology Unit, Medical Research Council, Cancer Epidemiology Unit, University of Oxford [Oxford]-Cancer Epidemiology Unit, WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene-Epidemiology and Medical Statistics-Athens Medical School, Department of Hygiene, Epidemiology and Medical Statistics, Harvard School of Public Health, Bureau of Epidemiologic Research, Academy of Athens, Molecular and Nutritional Epidemiology Unit, ISPO-Cancer Research and Prevention Institute, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Cancer Registry, Civile - M.P.Arezzo Hospital, CPO Piemonte, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Department of Public Health and Clinical Medicine/Nutritional Research, Umeå University, Nutrition and Metabolism Section, International Agency for Cancer Research (IACR), Unit of Nutrition, Environment, and Cancer, Equipe 6, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Genomics of Common Disease, Imperial College London-School of public health, The University of Hong Kong (HKU)-The University of Hong Kong (HKU), Department of Epidemiology and Biostatistics, Imperial College London-Faculty of Medicine-School of public health, Department of Epidemiology and Public Health, Imperial College London, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Aalborg Hospital-Aarhus University Hospital, Consorcio de Investigación Biomédica en Red especializado en Epidemiología y Salud Pública ( CIBERESP ), Andalusian School of Public Health, University of Cambridge [UK] ( CAM ), Azienda Ospedaliera 'Civile M.P.Arezzo', National Institute for Public Health and the Environment [Bilthoven] ( RIVM ), University of Umeå, International Agency for Research on Cancer, Centre de Recherche en Cancérologie de Lyon ( CRCL ), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 ( UCBL ), and Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
Oncology, Male, MESH: Carcinoma, Epidemiology, protein p53, MESH : Aged, PROTEIN, Genome-wide association study, MESH : Genotype, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, KAPPA-B ACTIVATION, MESH: Genotype, 0302 clinical medicine, PKC-IOTA, Epidemiology of cancer, Multicenter Studies as Topic, TUBEROUS SCLEROSIS, MESH: Genetic Variation, lcsh:Science, MESH : Isoenzymes, 0303 health sciences, MESH: Middle Aged, MESH : Carcinoma, TOR Serine-Threonine Kinases, Cancer Risk Factors, target of rapamycin kinase, MTOR protein, MESH: Case-Control Studies, 3. Good health, 030220 oncology & carcinogenesis, Medicine, Science & Technology - Other Topics, MESH : Genome-Wide Association Study, Phenomena and Processes::Genetic Phenomena::Genetic Variation [Medical Subject Headings], MESH : Prostatic Neoplasms, Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::Signal Transduction [Medical Subject Headings], medicine.medical_specialty, MESH : Case-Control Studies, Genotype, Single-nucleotide polymorphism, Variación genética, 03 medical and health sciences, Genetics, Cancer Genetics, Humans, MESH : Middle Aged, human, Biology, mammalian target of rapamycin, Aged, Estudio Multicéntrico, Science & Technology, MESH: Humans, MULTIDISCIPLINARY SCIENCES, lcsh:R, MESH : Humans, Genetic Variation, medicine.disease, MESH : Neoplasms, Genitourinary Tract Tumors, Genetic epidemiology, Cardiovascular and Metabolic Diseases, Case-Control Studies, KINASE-C-IOTA, MESH: Genome-Wide Association Study, MESH: Multicenter Studies as Topic, lcsh:Q, MESH : Genetic Predisposition to Disease, RAPAMYCIN, Lifestyle Causes of Cancer, MESH: Signal Transduction, Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Multicenter Studies as Topic [Medical Subject Headings], lcsh:Medicine, Bioinformatics, MESH : Multicenter Studies as Topic, Prostate cancer, Risk Factors, MESH: Risk Factors, Neoplasms, Clinical Epidemiology, MESH: Neoplasms, Protein Kinase C, MESH: Aged, Multidisciplinary, Prostate Cancer, MESH: Genetic Predisposition to Disease, Middle Aged, MESH : Risk Factors, European Prospective Investigation into Cancer and Nutrition, Europe, Isoenzymes, Diseases::Male Urogenital Diseases::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms [Medical Subject Headings], Genetic Epidemiology, protein kinase C lambda, MESH: Isoenzymes, MESH : TOR Serine-Threonine Kinases, isoenzyme, Cancer Epidemiology, Signal Transduction, Research Article, MESH : Male, Genetic Causes of Cancer, MESH : Europe, [SDV.CAN]Life Sciences [q-bio]/Cancer, Neoplasias de la Próstata, Genetic polymorphisms, Serina-Treonina Quinasas TOR, Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings], Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease [Medical Subject Headings], LUNG-CANCER, MESH : Genetic Variation, Internal medicine, medicine, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::TOR Serine-Threonine Kinases [Medical Subject Headings], Genetic Predisposition to Disease, MESH : Protein Kinase C, PI3K/AKT/mTOR pathway, Genetic Association Studies, MESH: TOR Serine-Threonine Kinases, 030304 developmental biology, MESH : Signal Transduction, COMPLEX, Càncer de pròstata, Polimorfisme genètic, Carcinoma, MTOR protein, human, protein kinase C, Cancer, Prostatic Neoplasms, Cancers and Neoplasms, Human Genetics, MESH: Protein Kinase C, MESH: Male, MAMMALIAN TARGET, MESH: Prostatic Neoplasms, CELL-GROWTH, MESH: Europe, EPIC, Genome-Wide Association Study
Abstract

International audience; The mTOR (mammalian target of rapamycin) signal transduction pathway integrates various signals, regulating ribosome biogenesis and protein synthesis as a function of available energy and amino acids, and assuring an appropriate coupling of cellular proliferation with increases in cell size. In addition, recent evidence has pointed to an interplay between the mTOR and p53 pathways. We investigated the genetic variability of 67 key genes in the mTOR pathway and in genes of the p53 pathway which interact with mTOR. We tested the association of 1,084 tagging SNPs with prostate cancer risk in a study of 815 prostate cancer cases and 1,266 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). We chose the SNPs (n = 11) with the strongest association with risk (p

Published
2011

24. Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer.

Author

Campa D, Hüsing A, Dostal L, Stein A, Drogan D, Boeing H, Tjønneland A, Roswall N, Østergaard JN, Overvad K, Rodríguez L, Bonet C, Sánchez MJ, Larrañaga N, Huerta JM, Ardanaz E, Khaw KT, Wareham N, Travis RC, Allen NE, Trichopoulou A, Zylis D, Karapetyan T, Palli D, Sieri S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Lenner P, Johansson M, Jenab M, Cox D, Siddiq A, Kaaks R, and Canzian F

Subjects
Adult, Aged, Case-Control Studies, Cohort Studies, Europe epidemiology, Forkhead Box Protein O3, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Prostatic Neoplasms epidemiology, Prostatic Neoplasms pathology, Risk Factors, Signal Transduction, White People, Forkhead Transcription Factors genetics, Prostatic Neoplasms genetics
Abstract

Forkhead box O3 (FOXO3) has a wide range of functions: it promotes tumor suppression, cell cycle arrest, repair of damaged DNA, detoxification of reactive oxygen species, apoptosis and plays a pivotal role in promoting longevity. FOXO3 is a key downstream target of the PI3K-Akt pathway in response to cellular stimulation by growth factors or insulin and has been proposed as a bridge between ageing and tumor suppression. Three SNPs in the FOXO3 gene (rs3800231, rs9400239 and rs479744) that have been shown to be strongly and consistently associated with longevity, were examined in relation to PC risk in a case control study of 1571 incident PC cases and 1840 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). There was no statistically significant association between the SNPs and PC risk regardless of the model of inheritance (dominant, codominant and recessive). The associations were not modified by disease aggressiveness, circulating levels of steroid sex hormones, or IGFs or BMI. We conclude that polymorphisms in the FOXO3 gene that are associated with longevity are not major risk factors for PC risk, in this population of Caucasian men.

Published
2011
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