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10 results on '"Dossou-Dagba, Ida"'

4. Regulatory T cell homing and activation is a signature of neonatal sepsis.

Author

Sossou, Darius, Ezinmegnon, Sem, Agbota, Gino, Gbedande, Komi, Accrombessi, Manfred, Massougbodji, Achille, d’Almeida, Marceline, Alao, Jules M., Dossou-Dagba, Ida, Pachot, Alexandre, Vachot, Laurence, Brengel-Pesce, Karen, Cottrell, Gilles, Yessoufou, Akadiri, Briand, Valérie, Tissières, Pierre, and Fievet, Nadine

Subjects
REGULATORY T cells, NEONATAL sepsis, T cells, NEWBORN infants
Abstract

Regulatory T cells (Treg) play a prominent role in utero tolerating non-inherited maternal antigens and in regulating immune responses against pathogens at birth. This study investigates Treg immunity in newborns in West Africa, where sepsis remains a major public health problem. Treg phenotypes on neonates subgroups with early-onset sepsis (EOS), presumed sepsis, and healthy newborn with and without prenatal risk factors were evaluated. Treg phenotypes varied according to prenatal conditions, with increase in Treg frequency and Foxp3 expression in healthy newborns with prenatal risk factors compared to those with none risk. Compared to healthy newborns with prenatal risk factors, EOS neonates had a significantly reduced frequency of Treg and Foxp3 expression. In the Treg pool, higher frequency of activated Treg was observed in EOS neonates, suggesting an in-utero activation upstream of the sepsis onset. Their migration to the infection site may explain the reduced frequency of circulating Integrin α4β1+ Treg suggestive of homing to the endothelial tissue. EOS neonates show increases expression of CTLA-4, PD-1 and CD39 on Treg, which negatively regulate the activation of effector T cells (Teff) corroborating by the lower frequency of Teff in EOS neonates. The higher frequency of CD39+ Treg and the lower frequency of integrinα4β1+ Treg in EOS non-survivor suggests that Treg exhaustement and endothelial homing are associated with outcome severity. Neonates developing EOS are born with an altered Treg phenotypic profile. Treg expression of CTLA-4, PD-1, CD39, and integrinα4β1 cell markers can be considered as early warning or diagnostic markers of EOS. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Elevated plasma IL-8 as a risk factor for mortality in children presenting with cerebral malaria (NeuroCM study)

Author

Royo, Jade, primary, Vianou, Bertin, additional, Accrombessi, Manfred, additional, Kinkpé, Elisée, additional, Ayédadjou, Linda, additional, Dossou-Dagba, Ida, additional, Ladipo, Yélé, additional, Alao, Maroufou Jules, additional, Bertin, Gwladys I, additional, Cot, Michel, additional, Boumediene, Farid, additional, Houzé, Sandrine, additional, Faucher, Jean-François, additional, Aubouy, Agnès, additional, and group, collaborators NeuroCM, additional

Published
2022
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6. Additional file 1 of Non-traumatic coma in young children in Benin: are viral and bacterial infections gaining ground on cerebral malaria?

Author

Brisset, Josselin, Angendu Baki, Karl, Watier, Laurence, Kinkp��, Elis��e, Bailly, Justine, Ay��dadjou, Linda, Alao, Maroufou Jules, Dossou-Dagba, Ida, Bertin, Gwladys I., Cot, Michel, Boum��di��ne, Farid, Ajzenberg, Daniel, Aubouy, Agn��s, Houz��, Sandrine, and Faucher, Jean-Fran��ois

Abstract

Additional file 1: Figure S1. Map of Benin with focus on Cotonou and the 2 study sites. Figure S2. Coma etiologies: graphical presentation.

Published
2022
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7. Host Immunity Biomarkers of Neonatal Sepsis: A Prospective, Multicentre Study in Sub Saharan Africa

Author

Ezinmegnon, Sem, primary, Mommert, Marine, additional, Bartolo, Francois, additional, Agbota, Gino, additional, Darius, Sossou, additional, Briand, Valérie, additional, d’Almeida, Marceline, additional, Alao, Maroufou Jules, additional, Dossou-Dagba, Ida, additional, Massougbodji, Achille, additional, Lausten-Thomsen, Ulrik, additional, Pachot, Alexandre, additional, Vachot, Laurence, additional, Yugueros-Marcos, Javier, additional, Brengel-Pesce, Karen, additional, Fievet, Nadine, additional, and Tissieres, Pierre, additional

Published
2021
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8. SEPSIS project: a protocol for studying biomarkers of neonatal sepsis and immune responses of infants in a malaria-endemic region

Author

Fievet, Nadine, primary, Ezinmegnon, Sem, additional, Agbota, Gino, additional, Sossou, Darius, additional, Ladekpo, Rodolphe, additional, Gbedande, Komi, additional, Briand, Valerie, additional, Cottrell, Gilles, additional, Vachot, Laurence, additional, Yugueros Marcos, Javier, additional, Pachot, Alexandre, additional, Textoris, Julien, additional, Blein, Sophie, additional, Lausten-Thomsen, Ulrik, additional, Massougbodji, Achille, additional, Bagnan, Lehila, additional, Tchiakpe, Nicole, additional, d'Almeida, Marceline, additional, Alao, Jules, additional, Dossou-Dagba, Ida, additional, and Tissieres, Pierre, additional

Published
2020
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9. Caractérisation des liquides cérébro-spinaux dans les comas pédiatriques non-traumatiques en one d'endémie palustre

Author

Mowendabeka, A, Ayedadjou, L, Kinkpé, E., Bailly, J, Alao, J., Dossou-Dagba, Ida, Ajzenberg, Daniel, Deloron, Philippe, Houzé, Sandrine, Faucher, Jean François, Grelier, Elisabeth, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Parasitologie Mycologie [CHU Limoges], CHU Limoges, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5), laboratoire parasitologie, CHU Bichat Paris, Ministère de la santé, Service des Maladies infectieuses et tropicales [CHU Limoges], CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), and Mère et enfant face aux infections tropicales (MERIT - UMR_D 216)

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

10. Identification of Plasmodium falciparum and host factors associated with cerebral malaria: description of the protocol for a prospective, case-control study in Benin (NeuroCM)

Author

Joste, Valentin, primary, Maurice, Laurine, additional, Bertin, Gwladys I, additional, Aubouy, Agnès, additional, Boumédiène, Farid, additional, Houzé, Sandrine, additional, Ajzenberg, Daniel, additional, Argy, Nicolas, additional, Massougbodji, Achille, additional, Dossou-Dagba, Ida, additional, Alao, Maroufou Jules, additional, Cot, Michel, additional, Deloron, Philippe, additional, and Faucher, Jean-François, additional

Published
2019
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