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This study reports on CHAMPS, a youth tobacco and prevention program intervention that focused on peer-led educational activities. Nineteen schools implemented a CHAMPS tobacco prevention program in grades 5, 6, and 7. Six schools served as nonintervention comparison sites. Baseline and follow-up questionnaires were completed by 1,412 students. The proportion of students reporting current cigarette use decreased significantly in the CHAMPS group but not in the comparison group. Intervention group students' knowledge about the harmful consequences of tobacco use increased significantly, whereas knowledge essentially stayed the same among comparison group students. Finally, the number of nonsmoking students who reported they would smoke a cigarette if one of their best friends offered it increased significantly in the comparison group but not in the intervention group. These results suggest that a well-planned and implemented peer-helping program represents an important potential resource that should be considered as a welcome adjunct to existing school-based tobacco education and prevention efforts. (Contains 1 table.)

Abstract Background Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion within the huntingtin gene. Mutant huntingtin protein misfolds and accumulates within neurons where it mediates its toxic effects. Promoting mutant huntingtin clearance by activating macroautophagy is one approach for treating Huntington's disease (HD). In this study, we evaluated the mTOR kinase inhibitor and macroautophagy promoting drug everolimus in the R6/2 mouse model of HD. Results Everolimus decreased phosphorylation of the mTOR target protein S6 kinase indicating brain penetration. However, everolimus did not activate brain macroautophagy as measured by LC3B Western blot analysis. Everolimus protected against early declines in motor performance; however, we found no evidence for neuroprotection as determined by brain pathology. In muscle but not brain, everolimus significantly decreased soluble mutant huntingtin levels. Conclusions Our data suggests that beneficial behavioral effects of everolimus in R6/2 mice result primarily from effects on muscle. Even though everolimus significantly modulated its target brain S6 kinase, this did not decrease mutant huntingtin levels or provide neuroprotection.

The article presents the discussion on elected officials knowing an organization's views on issues through personal meetings. Topics include group of people from a lawmaker's district requesting a meeting, email, or calling about a parricular issue; and protecting the health and safety of patients by opposing efforts of health care practitioners for seeking licensure or recognition.