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239 results on '"Dorsch, Marion"'

1. Evaluation of Protein Kinase cAMP-Activated Catalytic Subunit Alpha as a Therapeutic Target for Fibrolamellar Carcinoma

Author

Schalm, Stefanie S., O’Hearn, Erin, Wilson, Kevin, LaBranche, Timothy P., Silva, Grace, Zhang, Zhuo, DiPietro, Lucian, Bifulco, Neil, Woessner, Richard, Stransky, Nicolas, Sappal, Darshan, Campbell, Robert, Lobbardi, Riadh, Palmer, Michael, Kim, Joseph, Ye, Chaoyang, Dorsch, Marion, Lengauer, Christoph, Guzi, Timothy, Kadambi, Vivek, Garner, Andrew, and Hoeflich, Klaus P.

Published
2023
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2. An ALK2 inhibitor, BLU-782, prevents heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva

Author

Davis, Alison J., primary, Brooijmans, Natasja, additional, Brubaker, Jason D., additional, Stevison, Faith, additional, LaBranche, Timothy P., additional, Albayya, Faris, additional, Fleming, Paul, additional, Hodous, Brian L., additional, Kim, Joseph L., additional, Kim, Sean, additional, Lobbardi, Riadh, additional, Palmer, Michael, additional, Sheets, Michael P., additional, Vassiliadis, John, additional, Wang, Ruduan, additional, Williams, Brett D., additional, Wilson, Douglas, additional, Xu, Lan, additional, Zhu, Xing Julia, additional, Bouchard, Keith, additional, Hunter, Jeffrey W., additional, Graul, Chris, additional, Greenblatt, Elliot, additional, Hussein, Amira, additional, Lyon, Morgan, additional, Russo, Joelle, additional, Stewart, Rachel, additional, Dorsch, Marion, additional, Guzi, Timothy J., additional, Kadambi, Vivek, additional, Lengauer, Christoph, additional, and Garner, Andrew P., additional

Published
2024
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3. A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

Author

Mahoney, Christopher E., Pirman, David, Chubukov, Victor, Sleger, Taryn, Hayes, Sebastian, Fan, Zi Peng, Allen, Eric L., Chen, Ying, Huang, Lingling, Liu, Meina, Zhang, Yingjia, McDonald, Gabrielle, Narayanaswamy, Rohini, Choe, Sung, Chen, Yue, Gross, Stefan, Cianchetta, Giovanni, Padyana, Anil K., Murray, Stuart, Liu, Wei, Marks, Kevin M., Murtie, Joshua, Dorsch, Marion, Jin, Shengfang, Nagaraja, Nelamangala, Biller, Scott A., Roddy, Thomas, Popovici-Muller, Janeta, and Smolen, Gromoslaw A.

Published
2019
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4. Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

Author

Bunse, Lukas, Pusch, Stefan, Bunse, Theresa, Sahm, Felix, Sanghvi, Khwab, Friedrich, Mirco, Alansary, Dalia, Sonner, Jana K., Green, Edward, Deumelandt, Katrin, Kilian, Michael, Neftel, Cyril, Uhlig, Stefanie, Kessler, Tobias, von Landenberg, Anna, Berghoff, Anna S., Marsh, Kelly, Steadman, Mya, Zhu, Dongwei, Nicolay, Brandon, Wiestler, Benedikt, Breckwoldt, Michael O., Al-Ali, Ruslan, Karcher-Bausch, Simone, Bozza, Matthias, Oezen, Iris, Kramer, Magdalena, Meyer, Jochen, Habel, Antje, Eisel, Jessica, Poschet, Gernot, Weller, Michael, Preusser, Matthias, Nadji-Ohl, Minou, Thon, Niklas, Burger, Michael C., Harter, Patrick N., Ratliff, Miriam, Harbottle, Richard, Benner, Axel, Schrimpf, Daniel, Okun, Jürgen, Herold-Mende, Christel, Turcan, Sevin, Kaulfuss, Stefan, Hess‐Stumpp, Holger, Bieback, Karen, Cahill, Daniel P., Plate, Karl H., Hänggi, Daniel, Dorsch, Marion, Suvà, Mario L., Niemeyer, Barbara A., von Deimling, Andreas, Wick, Wolfgang, and Platten, Michael

Published
2018
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5. Data from AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations

Author

Yen, Katharine, primary, Travins, Jeremy, primary, Wang, Fang, primary, David, Muriel D., primary, Artin, Erin, primary, Straley, Kimberly, primary, Padyana, Anil, primary, Gross, Stefan, primary, DeLaBarre, Byron, primary, Tobin, Erica, primary, Chen, Yue, primary, Nagaraja, Raj, primary, Choe, Sung, primary, Jin, Lei, primary, Konteatis, Zenon, primary, Cianchetta, Giovanni, primary, Saunders, Jeffrey O., primary, Salituro, Francesco G., primary, Quivoron, Cyril, primary, Opolon, Paule, primary, Bawa, Olivia, primary, Saada, Véronique, primary, Paci, Angelo, primary, Broutin, Sophie, primary, Bernard, Olivier A., primary, de Botton, Stéphane, primary, Marteyn, Benoît S., primary, Pilichowska, Monika, primary, Xu, YingXia, primary, Fang, Cheng, primary, Jiang, Fan, primary, Wei, Wentao, primary, Jin, Shengfang, primary, Silverman, Lee, primary, Liu, Wei, primary, Yang, Hua, primary, Dang, Lenny, primary, Dorsch, Marion, primary, Penard-Lacronique, Virginie, primary, Biller, Scott A., primary, and Su, Shin-San Michael, primary

Published
2023
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6. Supplementary Tables 1 - 8 from AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations

Author

Yen, Katharine, primary, Travins, Jeremy, primary, Wang, Fang, primary, David, Muriel D., primary, Artin, Erin, primary, Straley, Kimberly, primary, Padyana, Anil, primary, Gross, Stefan, primary, DeLaBarre, Byron, primary, Tobin, Erica, primary, Chen, Yue, primary, Nagaraja, Raj, primary, Choe, Sung, primary, Jin, Lei, primary, Konteatis, Zenon, primary, Cianchetta, Giovanni, primary, Saunders, Jeffrey O., primary, Salituro, Francesco G., primary, Quivoron, Cyril, primary, Opolon, Paule, primary, Bawa, Olivia, primary, Saada, Véronique, primary, Paci, Angelo, primary, Broutin, Sophie, primary, Bernard, Olivier A., primary, de Botton, Stéphane, primary, Marteyn, Benoît S., primary, Pilichowska, Monika, primary, Xu, YingXia, primary, Fang, Cheng, primary, Jiang, Fan, primary, Wei, Wentao, primary, Jin, Shengfang, primary, Silverman, Lee, primary, Liu, Wei, primary, Yang, Hua, primary, Dang, Lenny, primary, Dorsch, Marion, primary, Penard-Lacronique, Virginie, primary, Biller, Scott A., primary, and Su, Shin-San Michael, primary

Published
2023
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7. Supplementary Figure 7 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

Author

Maira, Sauveur-Michel, primary, Pecchi, Sabina, primary, Huang, Alan, primary, Burger, Matthew, primary, Knapp, Mark, primary, Sterker, Dario, primary, Schnell, Christian, primary, Guthy, Daniel, primary, Nagel, Tobi, primary, Wiesmann, Marion, primary, Brachmann, Saskia, primary, Fritsch, Christine, primary, Dorsch, Marion, primary, Chène, Patrick, primary, Shoemaker, Kevin, primary, De Pover, Alain, primary, Menezes, Daniel, primary, Martiny-Baron, Georg, primary, Fabbro, Doriano, primary, Wilson, Christopher J., primary, Schlegel, Robert, primary, Hofmann, Francesco, primary, García-Echeverría, Carlos, primary, Sellers, William R., primary, and Voliva, Charles F., primary

Published
2023
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8. Supplementary Figure 3 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

Author

Maira, Sauveur-Michel, primary, Pecchi, Sabina, primary, Huang, Alan, primary, Burger, Matthew, primary, Knapp, Mark, primary, Sterker, Dario, primary, Schnell, Christian, primary, Guthy, Daniel, primary, Nagel, Tobi, primary, Wiesmann, Marion, primary, Brachmann, Saskia, primary, Fritsch, Christine, primary, Dorsch, Marion, primary, Chène, Patrick, primary, Shoemaker, Kevin, primary, De Pover, Alain, primary, Menezes, Daniel, primary, Martiny-Baron, Georg, primary, Fabbro, Doriano, primary, Wilson, Christopher J., primary, Schlegel, Robert, primary, Hofmann, Francesco, primary, García-Echeverría, Carlos, primary, Sellers, William R., primary, and Voliva, Charles F., primary

Published
2023
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9. Supplementary Figure 6 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

Author

Maira, Sauveur-Michel, primary, Pecchi, Sabina, primary, Huang, Alan, primary, Burger, Matthew, primary, Knapp, Mark, primary, Sterker, Dario, primary, Schnell, Christian, primary, Guthy, Daniel, primary, Nagel, Tobi, primary, Wiesmann, Marion, primary, Brachmann, Saskia, primary, Fritsch, Christine, primary, Dorsch, Marion, primary, Chène, Patrick, primary, Shoemaker, Kevin, primary, De Pover, Alain, primary, Menezes, Daniel, primary, Martiny-Baron, Georg, primary, Fabbro, Doriano, primary, Wilson, Christopher J., primary, Schlegel, Robert, primary, Hofmann, Francesco, primary, García-Echeverría, Carlos, primary, Sellers, William R., primary, and Voliva, Charles F., primary

Published
2023
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10. Supplementary Methods from AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations

Author

Yen, Katharine, primary, Travins, Jeremy, primary, Wang, Fang, primary, David, Muriel D., primary, Artin, Erin, primary, Straley, Kimberly, primary, Padyana, Anil, primary, Gross, Stefan, primary, DeLaBarre, Byron, primary, Tobin, Erica, primary, Chen, Yue, primary, Nagaraja, Raj, primary, Choe, Sung, primary, Jin, Lei, primary, Konteatis, Zenon, primary, Cianchetta, Giovanni, primary, Saunders, Jeffrey O., primary, Salituro, Francesco G., primary, Quivoron, Cyril, primary, Opolon, Paule, primary, Bawa, Olivia, primary, Saada, Véronique, primary, Paci, Angelo, primary, Broutin, Sophie, primary, Bernard, Olivier A., primary, de Botton, Stéphane, primary, Marteyn, Benoît S., primary, Pilichowska, Monika, primary, Xu, YingXia, primary, Fang, Cheng, primary, Jiang, Fan, primary, Wei, Wentao, primary, Jin, Shengfang, primary, Silverman, Lee, primary, Liu, Wei, primary, Yang, Hua, primary, Dang, Lenny, primary, Dorsch, Marion, primary, Penard-Lacronique, Virginie, primary, Biller, Scott A., primary, and Su, Shin-San Michael, primary

Published
2023
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11. Supplementary Figures 1 - 11 from AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations

Author

Yen, Katharine, primary, Travins, Jeremy, primary, Wang, Fang, primary, David, Muriel D., primary, Artin, Erin, primary, Straley, Kimberly, primary, Padyana, Anil, primary, Gross, Stefan, primary, DeLaBarre, Byron, primary, Tobin, Erica, primary, Chen, Yue, primary, Nagaraja, Raj, primary, Choe, Sung, primary, Jin, Lei, primary, Konteatis, Zenon, primary, Cianchetta, Giovanni, primary, Saunders, Jeffrey O., primary, Salituro, Francesco G., primary, Quivoron, Cyril, primary, Opolon, Paule, primary, Bawa, Olivia, primary, Saada, Véronique, primary, Paci, Angelo, primary, Broutin, Sophie, primary, Bernard, Olivier A., primary, de Botton, Stéphane, primary, Marteyn, Benoît S., primary, Pilichowska, Monika, primary, Xu, YingXia, primary, Fang, Cheng, primary, Jiang, Fan, primary, Wei, Wentao, primary, Jin, Shengfang, primary, Silverman, Lee, primary, Liu, Wei, primary, Yang, Hua, primary, Dang, Lenny, primary, Dorsch, Marion, primary, Penard-Lacronique, Virginie, primary, Biller, Scott A., primary, and Su, Shin-San Michael, primary

Published
2023
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12. Supplementary Materials, Tables 1-2, Figure Legends 1-8 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

Author

Maira, Sauveur-Michel, primary, Pecchi, Sabina, primary, Huang, Alan, primary, Burger, Matthew, primary, Knapp, Mark, primary, Sterker, Dario, primary, Schnell, Christian, primary, Guthy, Daniel, primary, Nagel, Tobi, primary, Wiesmann, Marion, primary, Brachmann, Saskia, primary, Fritsch, Christine, primary, Dorsch, Marion, primary, Chène, Patrick, primary, Shoemaker, Kevin, primary, De Pover, Alain, primary, Menezes, Daniel, primary, Martiny-Baron, Georg, primary, Fabbro, Doriano, primary, Wilson, Christopher J., primary, Schlegel, Robert, primary, Hofmann, Francesco, primary, García-Echeverría, Carlos, primary, Sellers, William R., primary, and Voliva, Charles F., primary

Published
2023
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13. Supplementary Figure 5 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

Author

Maira, Sauveur-Michel, primary, Pecchi, Sabina, primary, Huang, Alan, primary, Burger, Matthew, primary, Knapp, Mark, primary, Sterker, Dario, primary, Schnell, Christian, primary, Guthy, Daniel, primary, Nagel, Tobi, primary, Wiesmann, Marion, primary, Brachmann, Saskia, primary, Fritsch, Christine, primary, Dorsch, Marion, primary, Chène, Patrick, primary, Shoemaker, Kevin, primary, De Pover, Alain, primary, Menezes, Daniel, primary, Martiny-Baron, Georg, primary, Fabbro, Doriano, primary, Wilson, Christopher J., primary, Schlegel, Robert, primary, Hofmann, Francesco, primary, García-Echeverría, Carlos, primary, Sellers, William R., primary, and Voliva, Charles F., primary

Published
2023
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14. Supplementary Figure 8 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

Author

Maira, Sauveur-Michel, primary, Pecchi, Sabina, primary, Huang, Alan, primary, Burger, Matthew, primary, Knapp, Mark, primary, Sterker, Dario, primary, Schnell, Christian, primary, Guthy, Daniel, primary, Nagel, Tobi, primary, Wiesmann, Marion, primary, Brachmann, Saskia, primary, Fritsch, Christine, primary, Dorsch, Marion, primary, Chène, Patrick, primary, Shoemaker, Kevin, primary, De Pover, Alain, primary, Menezes, Daniel, primary, Martiny-Baron, Georg, primary, Fabbro, Doriano, primary, Wilson, Christopher J., primary, Schlegel, Robert, primary, Hofmann, Francesco, primary, García-Echeverría, Carlos, primary, Sellers, William R., primary, and Voliva, Charles F., primary

Published
2023
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15. Supplementary Figure 2 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

Author

Maira, Sauveur-Michel, primary, Pecchi, Sabina, primary, Huang, Alan, primary, Burger, Matthew, primary, Knapp, Mark, primary, Sterker, Dario, primary, Schnell, Christian, primary, Guthy, Daniel, primary, Nagel, Tobi, primary, Wiesmann, Marion, primary, Brachmann, Saskia, primary, Fritsch, Christine, primary, Dorsch, Marion, primary, Chène, Patrick, primary, Shoemaker, Kevin, primary, De Pover, Alain, primary, Menezes, Daniel, primary, Martiny-Baron, Georg, primary, Fabbro, Doriano, primary, Wilson, Christopher J., primary, Schlegel, Robert, primary, Hofmann, Francesco, primary, García-Echeverría, Carlos, primary, Sellers, William R., primary, and Voliva, Charles F., primary

Published
2023
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16. Supplementary Figure 1 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

Author

Maira, Sauveur-Michel, primary, Pecchi, Sabina, primary, Huang, Alan, primary, Burger, Matthew, primary, Knapp, Mark, primary, Sterker, Dario, primary, Schnell, Christian, primary, Guthy, Daniel, primary, Nagel, Tobi, primary, Wiesmann, Marion, primary, Brachmann, Saskia, primary, Fritsch, Christine, primary, Dorsch, Marion, primary, Chène, Patrick, primary, Shoemaker, Kevin, primary, De Pover, Alain, primary, Menezes, Daniel, primary, Martiny-Baron, Georg, primary, Fabbro, Doriano, primary, Wilson, Christopher J., primary, Schlegel, Robert, primary, Hofmann, Francesco, primary, García-Echeverría, Carlos, primary, Sellers, William R., primary, and Voliva, Charles F., primary

Published
2023
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17. Supplementary Figure 4 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

Author

Maira, Sauveur-Michel, primary, Pecchi, Sabina, primary, Huang, Alan, primary, Burger, Matthew, primary, Knapp, Mark, primary, Sterker, Dario, primary, Schnell, Christian, primary, Guthy, Daniel, primary, Nagel, Tobi, primary, Wiesmann, Marion, primary, Brachmann, Saskia, primary, Fritsch, Christine, primary, Dorsch, Marion, primary, Chène, Patrick, primary, Shoemaker, Kevin, primary, De Pover, Alain, primary, Menezes, Daniel, primary, Martiny-Baron, Georg, primary, Fabbro, Doriano, primary, Wilson, Christopher J., primary, Schlegel, Robert, primary, Hofmann, Francesco, primary, García-Echeverría, Carlos, primary, Sellers, William R., primary, and Voliva, Charles F., primary

Published
2023
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20. Supplementary Table 1 from The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells

Author

Jagani, Zainab, primary, Wiederschain, Dmitri, primary, Loo, Alice, primary, He, Dan, primary, Mosher, Rebecca, primary, Fordjour, Paul, primary, Monahan, John, primary, Morrissey, Michael, primary, Yao, Yung-Mae, primary, Lengauer, Christoph, primary, Warmuth, Markus, primary, Sellers, William R., primary, and Dorsch, Marion, primary

Published
2023
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21. Supplementary Figure Legends 1-13 from The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells

Author

Jagani, Zainab, primary, Wiederschain, Dmitri, primary, Loo, Alice, primary, He, Dan, primary, Mosher, Rebecca, primary, Fordjour, Paul, primary, Monahan, John, primary, Morrissey, Michael, primary, Yao, Yung-Mae, primary, Lengauer, Christoph, primary, Warmuth, Markus, primary, Sellers, William R., primary, and Dorsch, Marion, primary

Published
2023
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22. Supplemental Information from A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture In vitro

Author

Daniel, Vincent C., primary, Marchionni, Luigi, primary, Hierman, Jared S., primary, Rhodes, Jonathan T., primary, Devereux, Wendy L., primary, Rudin, Charles M., primary, Yung, Rex, primary, Parmigiani, Giovanni, primary, Dorsch, Marion, primary, Peacock, Craig D., primary, and Watkins, D. Neil, primary

Published
2023
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23. Supplemental Tables A-H from A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture In vitro

Author

Daniel, Vincent C., primary, Marchionni, Luigi, primary, Hierman, Jared S., primary, Rhodes, Jonathan T., primary, Devereux, Wendy L., primary, Rudin, Charles M., primary, Yung, Rex, primary, Parmigiani, Giovanni, primary, Dorsch, Marion, primary, Peacock, Craig D., primary, and Watkins, D. Neil, primary

Published
2023
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26. Supplementary Methods from The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells

Author

Jagani, Zainab, primary, Wiederschain, Dmitri, primary, Loo, Alice, primary, He, Dan, primary, Mosher, Rebecca, primary, Fordjour, Paul, primary, Monahan, John, primary, Morrissey, Michael, primary, Yao, Yung-Mae, primary, Lengauer, Christoph, primary, Warmuth, Markus, primary, Sellers, William R., primary, and Dorsch, Marion, primary

Published
2023
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27. Supplementary Figures 1-13 from The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells

Author

Jagani, Zainab, primary, Wiederschain, Dmitri, primary, Loo, Alice, primary, He, Dan, primary, Mosher, Rebecca, primary, Fordjour, Paul, primary, Monahan, John, primary, Morrissey, Michael, primary, Yao, Yung-Mae, primary, Lengauer, Christoph, primary, Warmuth, Markus, primary, Sellers, William R., primary, and Dorsch, Marion, primary

Published
2023
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31. PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene

Author

Guo, Zhuyan, Wang, Anlai, Zhang, Weidong, Levit, Mikhail, Gao, Qiang, Barberis, Claude, Tabart, Michel, Zhang, Jingxin, Hoffmann, Dietmar, Wiederschain, Dmitri, Rocnik, Jennifer, Sun, Fangxian, Murtie, Josh, Lengauer, Christoph, Gross, Stefan, Zhang, Bailin, Cheng, Hong, Patel, Vinod, Schio, Laurent, Adrian, Francisco, Dorsch, Marion, Garcia-Echeverria, Carlos, and Huang, Shih-Min A.

Published
2014
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32. A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model

Author

Wang, Fang, Travins, Jeremy, Lin, Zhizhong, Si, Yaguang, Chen, Yue, Powe, Josh, Murray, Stuart, Zhu, Dongwei, Artin, Erin, Gross, Stefan, Santiago, Stephanie, Steadman, Mya, Kernytsky, Andrew, Straley, Kimberly, Lu, Chenming, Pop, Ana, Struys, Eduard A., Jansen, Erwin E. W., Salomons, Gajja S., David, Muriel D., Quivoron, Cyril, Penard-Lacronique, Virginie, Regan, Karen S., Liu, Wei, Dang, Lenny, Yang, Hua, Silverman, Lee, Agresta, Samuel, Dorsch, Marion, Biller, Scott, Yen, Katharine, Cang, Yong, Su, Shin-San Michael, and Jin, Shengfang

Published
2016
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33. Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

Author

Wang, Fang, Travins, Jeremy, DeLaBarre, Byron, Penard-Lacronique, Virginie, Schalm, Stefanie, Hansen, Erica, Straley, Kimberly, Kernytsky, Andrew, Liu, Wei, Gliser, Camelia, Yang, Hua, Gross, Stefan, Artin, Erin, Saada, Veronique, Mylonas, Elena, Quivoron, Cyril, Popovici-Muller, Janeta, Saunders, Jeffrey O., Salituro, Francesco G., Yan, Shunqi, Murray, Stuart, Wei, Wentao, Gao, Yi, Dang, Lenny, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., de Botton, Stephane, and Yen, Katharine E.

Published
2013
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34. Evaluation of PRKACA as a Therapeutic Target for Fibrolamellar Carcinoma

Author

Schalm, Stefanie S., primary, O’Hearn, Erin, additional, Wilson, Kevin, additional, LaBranche, Timothy P., additional, Silva, Grace, additional, Zhang, Zhuo, additional, DiPietro, Lucian, additional, Bifulco, Neil, additional, Woessner, Richard, additional, Stransky, Nicolas, additional, Sappal, Darshan, additional, Campbell, Robert, additional, Lobbardi, Riadh, additional, Palmer, Michael, additional, Kim, Joseph, additional, Ye, Chaoyang, additional, Dorsch, Marion, additional, Lengauer, Christoph, additional, Guzi, Timothy, additional, Kadambi, Vivek, additional, Garner, Andrew, additional, and Hoeflich, Klaus P., additional

Published
2022
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36. Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

Author

Filbin, Mariella Gruber, Dabral, Sukriti K., Pazyra-Murphy, Maria F., Ramkissoon, Shakti, Kung, Andrew L., Pak, Ekaterina, Chung, Jarom, Theisen, Matthew A., Sun, Yanping, Franchetti, Yoko, Sun, Yu, Shulman, David S., Redjal, Navid, Tabak, Barbara, Beroukhim, Rameen, Wang, Qi, Zhao, Jean, Dorsch, Marion, Buonamici, Silvia, Ligon, Keith L., Kelleher, Joseph F., and Segal, Rosalind A.

Subjects
Gene expression -- Research, Viral antibodies -- Properties, Glioblastoma multiforme -- Development and progression -- Care and treatment, Cellular signal transduction -- Genetic aspects, Cancer cells -- Genetic aspects, Antibodies -- Properties, Biological sciences, Health
Abstract

In glioblastoma, phosphatidylinositol 3-kinase (PI3K) signaling is frequently activated by loss of the tumor suppressor phosphatase and tensin homolog (PTEN) (1). However, it is not known whether inhibiting PI3K represents [...]

Published
2013
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37. Unraveling the therapeutic potential of the hedgehog pathway in cancer

Author

Amakye, Dereck, Jagani, Zainab, and Dorsch, Marion

Subjects
Oncology, Experimental, Tumor necrosis factor inhibitors -- Properties, Cancer -- Care and treatment -- Research, Hedgehog proteins -- Properties, Biological sciences, Health
Abstract

Major progress has been made in recent years in the development of Hedgehog (Hh) pathway inhibitors for the treatment of patients with cancer. Promising clinical trial results have been obtained [...]

Published
2013
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38. Abstract 1262: BLU-701 is a highly potent, brain-penetrant and WT-sparing next-generation EGFR TKI for the treatment of sensitizing (ex19del, L858R) and C797S resistance mutations in metastatic NSCLC

Author

Conti, Chiara, primary, Campbell, John, additional, Woessner, Rich, additional, Guo, Jian, additional, Timsit, Yoav, additional, Iliou, Maria, additional, Wardwell, Scott, additional, Davis, Alison, additional, Chicklas, Sharon, additional, Hsieh, John, additional, Eno, Meredith, additional, Ahmad, Omar, additional, Fernando, Dilinie, additional, Barvian, Kevin, additional, Kim, Joseph, additional, Kazmirski, Steven, additional, Perola, Emanuele, additional, Dineen, Tom, additional, Brown, Victoria, additional, Guzi, Timothy, additional, Özen, Ayşegül, additional, Stevison, Faith, additional, Utt, Caitlin, additional, Medendorp, Clare, additional, Meissner, Robert, additional, Dorsch, Marion, additional, and Hoeflich, Klaus, additional

Published
2021
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39. Abstract 1467: BLU-945, a fourth-generation, potent and highly selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with intracranial activity, demonstrates robust in vivo antitumor activity in models of osimertinib-resistant non-small cell lung cancer (NSCLC)

Author

Lim, Sun Min, primary, Park, Chae Won, additional, Zhang, Zhuo, additional, Woessner, Rich, additional, Dineen, Tom, additional, Stevison, Faith, additional, Hsieh, John, additional, Eno, Meredith, additional, Wilson, Doug, additional, Campbell, John, additional, Utt, Caitlin, additional, Albayya, Faris, additional, Lamontagne, Nicolas, additional, Dorsch, Marion, additional, Hoeflich, Klaus, additional, Cho, Byoung Chul, additional, and Schalm, Stefanie, additional

Published
2021
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40. Abstract 1279: Development of a selective CDK2-E inhibitor in CCNE driven cancers

Author

Choi, Yoon J., primary, Wenglowsky, Steve, additional, Brown, Victoria, additional, Bifulco, Neil, additional, Choi, Yeon S., additional, Guo, Jian, additional, Hatlen, Megan, additional, Kim, Joseph, additional, LaBranche, Tim, additional, Lobbardi, Riadh, additional, Perola, Emanuele, additional, Rozsahegyi, Emily, additional, Maynard, Michelle, additional, Ramsden, Phil, additional, Silva, Grace, additional, Stevison, Faith, additional, Vargas, Richard, additional, Wang, Ruduan, additional, Wilson, Doug, additional, Woessner, Rich, additional, Zhang, Dean, additional, Meissner, Rob, additional, Hoeflich, Klaus, additional, and Dorsch, Marion, additional

Published
2021
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41. Abstract 1717: MAP4K1 inhibition enhances immune cell activation and anti-tumor immunity in preclinical tumor models

Author

Faia, Kerrie, primary, Toso, Alberto, additional, Fetalvero, Kristina, additional, Roche, Marly, additional, Bench, Steven, additional, O'Hearn, Erin, additional, Cao, Qiongfang, additional, Bright, Kerry-Ann, additional, Paduraru, Debora, additional, Romagnani, Andrea, additional, Weng, Weifan, additional, Zimmermann, Tina, additional, Burke, Michael, additional, Close, Joshua, additional, Green, Luke, additional, Kim, Joseph, additional, Miduturu, Chandra, additional, Ribeiro, Alison, additional, Bacac, Marina, additional, Herter, Sylvia, additional, Perola, Emanuele, additional, Sheets, Michael, additional, Eckmann, Jan, additional, Heidkamp, Gordon, additional, Traore, Tary, additional, Gerson, Erik, additional, Woessner, Rich, additional, Wolter, Carsten, additional, Scheuplein, Felix, additional, Perez, Nisha, additional, LaBranche, Timothy, additional, Silva, Grace, additional, Ye, Chaoyang, additional, Utt, Caitlin, additional, Gross, Stefan, additional, Bischoff, James R., additional, Dorsch, Marion, additional, Guzi, Tim, additional, Hoeflich, Klaus, additional, and Brubaker, Jason, additional

Published
2021
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42. A crucial requirement for Hedgehog signaling in small cell lung cancer

Author

Park, Kwon-Sik, Martelotto, Luciano G., Peifer, Martin, Sos, Martin L., Karnezis, Anthony N., Mahjoub, Moe R., Bernard, Katie, Conklin, Jamie F., Szczepny, Anette, Yuan, Jing, Guo, Ribo, Ospina, Beatrice, Falzon, Jeanette, Bennett, Samara, Brown, Tracey J., Markovic, Ana, Devereux, Wendy L., Ocasio, Cory A., Chen, James K., Stearns, Tim, Thomas, Roman K., Dorsch, Marion, Buonamici, Silvia, Watkins, D.Neil, Peacock, Craig D., and Sage, Julien

Subjects
Hedgehog proteins -- Physiological aspects -- Genetic aspects -- Research, Lung cancer, Non-small cell -- Development and progression -- Genetic aspects -- Care and treatment -- Research, Cellular signal transduction -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Small-cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer for which there is no effective treatment (1,2). Using a mouse model in which deletion of Rbl and Trp53 in the lung epithelium of adult mice induces SCLC (3,4), we found that the Hedgehog signaling pathway is activated in SCLC cells independently of the lung microenvironment. Constitutive activation of the Hedgehog signaling molecule Smoothened (Smo) promoted the clonogenicity of human SCLC in vitro and the initiation and progression of mouse SCLC in vivo. Reciprocally, deletion of Smo in Rbl and Trp53-mutant lung epithelial cells strongly suppressed SCLC initiation and progression in mice. Furthermore, pharmacological blockade of Hedgehog signaling inhibited the growth of mouse and human SCLC, most notably following chemotherapy. These findings show a crucial cell-intrinsic role for Hedgehog signaling in the development and maintenance of SCLC and identify Hedgehog pathway inhibition as a therapeutic strategy to slow the progression of disease and delay cancer recurrence in individuals with SCLC., Activation of Hedgehog signaling has been reported in a subset of human SCLC cell lines and tumors (5-8) without changes in Hedgehog pathway gene copy numbers (9). Furthermore, we sequenced [...]

Published
2011
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43. Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway

Author

Jagani, Zainab, Mora-Blanco, E. Lorena, Sansam, Courtney G., McKenna, Elizabeth S., Wilson, Boris, Chen, Dongshu, Klekota, Justin, Tamayo, Pablo, Nguyen, Phuong T.L., Tolstorukov, Michael, Park, Peter J., Cho, Yoon-Jae, Hsiao, Kathy, Buonamici, Silvia, Pomeroy, Scott L., Mesirov, Jill P., Ruffner, Heinz, Bouwmeester, Tewis, Luchansky, Sarah J., Murtie, Joshua, Kelleher, Joseph F., Warmuth, Markus, Sellers, William R., Roberts, Charles W.M., and Dorsch, Marion

Subjects
Tumors -- Risk factors -- Genetic aspects -- Research, Gene expression -- Research, Tumor suppressor genes -- Health aspects -- Research, Hedgehog proteins -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Aberrant activation of the Hedgehog (Hh) pathway can drive tumorigenesis (1). To investigate the mechanism by which glioma-associated oncogene family zinc finger-1 (GLI1), a crucial effector of Hh signaling (2), regulates Hh pathway activation, we searched for GLI1-interacting proteins. We report that the chromatin remodeling protein SNF5 (encoded by SMARCB1, hereafter called SNF5), which is inactivated in human malignant rhabdoid tumors (MRTs), interacts with GLI1. We show that Snf5 localizes to Gli1-regulated promoters and that loss of Snf5 leads to activation of the Hh-Gli pathway. Conversely, re-expression of SNF5 in MRT cells represses GLI1. Consistent with this, we show the presence of a Hh-Gli-activated gene expression profile in primary MRTs and show that GLI1 drives the growth of SNF5-deficient MRT cells in vitro and in vivo. Therefore, our studies reveal that SNF5 is a key mediator of Hh signaling and that aberrant activation of GLI1 is a previously undescribed targetable mechanism contributing to the growth of MRT cells., The Hh pathway has critical functions in tissue patterning and differentiation during development (1). Aberrant activation of the pathway resulting from mutations in the PTCH1 gene (encoding Patched-1 receptor) and [...]

Published
2010
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44. Abstract A118: Identification of resistance mechanisms to FGFR4 targeted therapy in hepatocellular carcinoma

Author

Hatlen, Megan A, primary, Schmidt-Kittler, Oleg, additional, Sherwin, Cori-Ann, additional, Rozsahegyi, Emily, additional, Rubin, Nooreen, additional, Sheets, Michael, additional, Kim, Joseph L, additional, Miduturu, Chandra, additional, Bifulco, Neil, additional, Brooijmans, Natasja, additional, Shi, Hongliang, additional, Guzi, Timothy, additional, Boral, Andy, additional, Lengauer, Christoph, additional, Dorsch, Marion, additional, Kim, Richard D, additional, Kang, Yoon-Koo, additional, Wolf, Beni B, additional, and Hoeflich, Klaus P, additional

Published
2019
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45. Abstract B127: Evaluating PRKACA as a therapeutic target for Fibrolamellar Carcinoma

Author

Schalm, Stefanie S, primary, O’Hearn, Erin, additional, Wilson, Kevin, additional, LaBranche, Timothy, additional, Silva, Grace, additional, DiPietro, Lucian, additional, Bifulco, Neil, additional, Woessner, Richard, additional, Stransky, Nicolas, additional, Sappal, Darshan, additional, Shutes, Adam, additional, Campbell, Robert, additional, Lobbardi, Riadh, additional, Palmer, Michael, additional, Kim, Joseph, additional, Miller, Stephen, additional, Dorsch, Marion, additional, Lengauer, Christoph, additional, Guzi, Timothy, additional, Kadambi, Vivek, additional, Garner, Andrew, additional, and Hoeflich, Klaus P, additional

Published
2019
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46. Acquired On-Target Clinical Resistance Validates FGFR4 as a Driver of Hepatocellular Carcinoma

Author

Hatlen, Megan A., primary, Schmidt-Kittler, Oleg, additional, Sherwin, Cori Ann, additional, Rozsahegyi, Emily, additional, Rubin, Nooreen, additional, Sheets, Michael P., additional, Kim, Joseph L., additional, Miduturu, Chandrasekhar, additional, Bifulco, Neil, additional, Brooijmans, Natasja, additional, Shi, Hongliang, additional, Guzi, Timothy, additional, Boral, Andy, additional, Lengauer, Christoph, additional, Dorsch, Marion, additional, Kim, Richard D., additional, Kang, Yoon-Koo, additional, Wolf, Beni B., additional, and Hoeflich, Klaus P., additional

Published
2019
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47. Validating cancer drug targets

Author

Benson, John D., Chen, Ying-Nan P., Cornell-Kennon, Susan A., Dorsch, Marion, Kim, Sunkyu, Leszczyniecka, Magdalena, Sellers, William R., and Lengauer, Christoph

Published
2006

48. Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma

Author

Hock, Hanno, Dorsch, Marion, Kunzendorf, Ulrich, Zhihai Qin, Diamantstein, Tibor, and Blankenstein, Thomas

Subjects
Tumor suppressor genes -- Research, Cytokines -- Analysis, Interleukins -- Usage, Science and technology
Abstract

The mechanisms of tumor rejection induced by various cytokines were directly compared. This involved the characterization of the cellular requirements for tumor rejection of five cytokines in parallel in the same tumor cell lines. In vivo antibody treatments and immunohistochemical analysis were used in the experiments. Results indicate that the tumor rejection of cytokines were not affected by the infiltration of T-cells.

Published
1993

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