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Two octa-coordinated lanthanum (III) complexes of deprotonated azaphosphor β-diketon and diimine ligands, [LnL 3 Q] (L = [Cl 2 CHC(O)NP(O)(NC 6 H 12 ) 2 ], Q = Phen (C1) and Bipy (C2)), were synthesized and characterized by elemental analysis, IR, and NMR spectra. X-ray crystallography revealed a distorted tetragonal antiprism LaO6N2 coordination geometry around the lanthanum atom in both compounds. Nano-sized complexes (Ć1 and Ć2) were synthesized via a sonochemical process and analyzed using SEM and XRPD. TGA-DTA analysis were performed on complexes in both bulk and nano scales. Redox behavior was also examined by cyclic voltammetry. The interaction between the complexes and calf thymus DNA (ct-DNA) was investigated using UV-Vis spectroscopy, fluorescence titration, viscosity measurements, and gel electrophoresis. C2 and Ć2 likely intercalate between DNA base pairs through van der Waals forces and hydrogen bonding, whereas C1 and Ć1 interact with DNA via groove binding. Further, result indicated the apparent association constant (K app ) in the range of 4.53 × 10 4  M -1 -26.86 × 10 4  M -1 with the highest value for nanocomplex Ć2. Fluorescence studies revealed dynamic and static quenching for C1, while the other compounds followed a static quenching process. Hirshfeld surface analysis and the NCI method were employed to demonstrate how non-covalent interactions influence the crystal packing through intermolecular interactions., Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Lung cancer has been one of the leading causes of death over the past century. Unfortunately, the reliance on conventional methods to diagnose the phenotypic properties of tumors hinders early-stage cancer diagnosis. However, recent advancements in identifying disease-specific nucleotide biomarkers, particularly microRNAs, have brought us closer to early-stage detection. The roles of miR-155, miR-197, and miR-182 have been established in stage I lung cancer. Recent progress in synthesizing nanomaterials with higher conductivity has enhanced the diagnostic sensitivity of electrochemical biosensors, which can detect low concentrations of targeted biomarkers. Therefore, this review article focuses on exploring electrochemical biosensors based on microRNA in lung cancer., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Pancreatic cancer (PC) is one of the deadliest cancers worldwide. MicroRNAs (miRs) are sensitive molecular diagnostic tools that can serve as highly accurate biomarkers in many disease states in general and cancer specifically. MiR-based electrochemical biosensors can be easily and inexpensively manufactured, making them suitable for clinical use and mass production for point-of-care use. This paper reviews nanomaterial-enhanced miR-based electrochemical biosensors in pancreatic cancer detection, analyzing both labeled and label-free approaches, as well as enzyme-based and enzyme-free methods., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

The significant role of microRNAs in regulating gene expression and in disease tracking has handed the possibility of robust and accurate diagnosis of various diseases. Measurement of these biomarkers has also had a significant impact on the preparation of natural samples. Discovery of miRNAs is a major challenge due to their small size in the real sample and their short length, which is generally measured by complex and expensive methods. Electrochemical nanobiosensors have made significant progress in this field. Due to the delicate nature of nerve tissue repair and the significance of rapid-fire feature of neurodegenerative conditions, these biosensors can be reliably promising. This review presents advances in the field of neurodegenerative diseases diagnostics. At the same time, there are still numerous openings in this field that are a bright prospect for researchers in the rapid-fire opinion of neurological diseases and indeed nerve tissue repair., (© 2022 International Union of Biochemistry and Molecular Biology, Inc.)

Gastrointestinal (GI) cancers are one of the most common causes of cancer-related mortality. The discovery of microRNAs (miRs) and their unique role in cancer and other diseases has prompted the development of highly sensitive molecular diagnostic tools using nanomaterials as sensitive and specific biosensors. Among these, electrochemical biosensors, which are based on a simple and inexpensive design, make them desirable in clinical applications as well as a mass-produced point-of-care device. We review miR-based electrochemical biosensors in GI cancer and examine the use of nanoparticles in the evolving development of miR-based biosensors. Among these, a number of approaches including redox labeled probes, catalysts, redox intercalating agents and free redox indicators are highlighted for use in electrochemical biosensor technology., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

The properties of the foot deployed in a bipedal robot that targets the rendering of a human-like dynamic gait are crucial. Firstly, it has to implement a set of mechanical mechanisms/properties that improve the efficiency of the locomotion. Secondly, it has to integrate a sensory system that captures the interaction with the ground with suitable precision. Both systems-the mechanical and the sensory system-have to be integrated as tightly as possible to keep the overall dimensions and weight low. Being the most distal element of the leg, especially the latter is crucial for favorable leg dynamics. Regarding the structural properties, a modern prosthetic foot poses a good solution and has hence been adopted in various bipeds. Their elaborated structures-mostly made from carbon fiber composites-are designed to imitate the mechanisms of the anthropomorphic counterpart. The following presents a concept to estimate the ground interaction based on the intrinsic deformation of a commercially available prosthesis. To measure the deformation, strain gauges are applied to its main structural elements. Using this information, the center of pressure and the normal force acting on it are estimated. The performance of two approaches-linear regression and neural networks-is presented and compared. Finally, the accuracy of the strain-based estimation is evaluated in two experiments and compared to a conventional force/torque sensor (FTS)-based system and a pressure insole. While the presented work is initially motivated by robotics research, it might as well be transferred to the design of a modern actively actuated prosthesis.

The dandelion-shaped nanostructure of an organotin complex with formula Sn(CH 3 ) 2 Cl 2 }NC 5 H 4 C(O)NHP(O)[NHC 6 H 11 ] 2 } 2 (C 1 ) was synthesized by means of a sonochemical method. Nano-structures were characterized by elemental analysis, NMR, SEM-EDS, XRD, UV-Vis, and FT-IR spectroscopy. The thermal stability of the complex C 1 has been studied by thermal gravimetric analysis (TGA), and compared to the bulk form (C 2 ). Both the morphology and the size of the ultrasound-assisted synthesized organotin complex have been investigated using scanning electron microscopy (SEM) by changing such parameters as the concentration of initial reactants and the sonication frequency. Two different forms of the organotin complex (C 1 , C 2 ) and the corresponding ligand (L) were evaluated by a modified Ellman's method on acetyl- and butyrylcholinesterase enzymes. Nanodendalion C 1 and ligand L showed the best activity against AChE and BChE, respectively, with the IC 50 values being 326.59 μg/ml and 426.68 μg/ml. Further, Lineweaver Burk plots indicated that these compounds are mixed inhibitors. The synthesized compounds and cholinesterase enzymes were simulated by molecular docking for more details concerning the conformation and the orientations of these compounds in the active site of the receptor., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Background and Aim: Hospital Information Systems (HIS) are used for easy access to information, improvement of documentation and reducing errors. Nonetheless, using these systems is faced with some barriers and obstacles. This study identifies the challenges and the obstacles of using these systems in the academic and non-academic hospitals in Kerman., Methods: This is a cross-sectional study which was carried out in 2015. The statistical population in this study consisted of the nurses who had been working in the academic and non-academic hospitals in Kerman. A questionnaire consisting of two sections was used. The first section consisted of the demographic information of the participants and the second section comprised 34 questions about the challenges of HIS use. Data were analyzed by the descriptive and statistical analysis (t-test, and ANOVA) using SPSS 19 software., Results: The most common and important challenges in the academic hospitals were about human environment factors, particularly "negative attitude of society toward using HIS". In the non-academic hospitals, the most common and important challenges were related to human factors, and among them, "no incentive to use system" was the main factor. The results of the t-test method revealed that there was a significant relationship between gender and the mean score of challenges related to the organizational environment category in the academic hospitals and between familiarity with HIS and mean score of human environment factors (p<0.05). The results of the ANOVA test also revealed that the educational degree and work experience in the healthcare environment (years) in the academic hospitals have a significant relationship with the mean score related to the hardware challenges, as well, experience with HIS has a significant relationship, with the mean score related to the human challenges (p<0.05)., Conclusion: The most important challenges in using the information systems are the factors related to the human environment and the human factors. The results of this study can bring a good perspective to the policy makers and the managers regarding obstacles of using HISs from the nurses' perspective, so that they can solve their problems and can successfully implement these systems., Competing Interests: Conflict of Interest: There is no conflict of interest to be declared.