Information technology is a cornerstone of any space mission, and operating a multi-mission center increases the demands for efficient and effective information technology management. Simultaneously, the independent budget lines and requirements of multiple missions work against organization-wide information technology services and maintaining an integrated, manageable and affordable information technology architecture. With the Hubble Space Telescope in the prime of its science mission, the James Webb Space Telescope in development, and participation in numerous other missions, the Space Telescope Science Institute (STScI) has made several changes to increase the effectiveness and flexibility of information technology support. A clear approach to technology governance is used to develop high-level policy and involve all groups in establishing and communicating cross-mission strategies and priorities. The information technology organization is structured to support mission operations and general users, while protecting resources for development and deployment of changes to the technology infrastructure. Additionally, a strategic planning group performs mid- and long-term information technology planning, collaborating with other groups. This paper presents these changes and evaluates how well they address issues and challenges facing our missions.