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2. TNFRII polymorphism is associated with response to TNF blockers in rheumatoid arthritis patients seronegative for ACPA

Author

Vincent Daien, Christian Jorgensen, Isabelle Touitou, Sylvie Fabre, Patrice Ravel, Yves-Marie Pers, Doris Cadart, Cécile Rittore, Service d'immuno-rhumatologie[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques (LGMR), Université Montpellier 1 (UM1)-IFR3, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre de Biochimie Structurale [Montpellier] (CBS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Montpellier, and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
Adult, Male, [SDV]Life Sciences [q-bio], Peptides, Cyclic, Arthritis, Rheumatoid, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Rheumatology, Predictive Value of Tests, SNP LTA + 720, medicine, Humans, Receptors, Tumor Necrosis Factor, Type II, Anti-citrullinated peptide antibodies (ACPA), ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Aged, 030203 arthritis & rheumatology, Aged, 80 and over, 0303 health sciences, Polymorphism, Genetic, Genetic polymorphism, business.industry, Tumor Necrosis Factor-alpha, Joint bone, Middle Aged, medicine.disease, 3. Good health, SNP TNFRII-codon 196, Rheumatoid arthritis, Antirheumatic Agents, Immunology, Tumor necrosis factor alpha, TNF response, business, SNP IL10-1087, Biomarkers
Abstract

Joint Bone Spine - In Press.Proof corrected by the author Available online since jeudi 23 janvier 2014

Published
2014
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3. TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis

Author

Sylvie Fabre, Nicolas Molinari, Stephan Soler, Gautier Tejedor, Cécile Rittore, Jean-Pierre Daurès, Christian Jorgensen, Vincent Daien, Claire Daïen, Isabelle Touitou, Doris Cadart, Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Institut Universitaire de Recherche Clinique, Mathématiques, Informatique et STatistique pour l'Environnement et l'Agronomie (MISTEA), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA), and Université Montpellier 1 (UM1)

Subjects
Male, rheumatoid arthritis, TNFAIP3, Arthritis, Rheumatoid, Antibodies, Monoclonal, Murine-Derived, 0302 clinical medicine, rituximab, TGF beta1, Genotype, [MATH]Mathematics [math], STAT4, 0303 health sciences, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, Middle Aged, STAT4 Transcription Factor, 3. Good health, DNA-Binding Proteins, Treatment Outcome, Antirheumatic Agents, Rheumatoid arthritis, Cytokines, Biomarker (medicine), biomarker, Female, Rituximab, medicine.drug, Adult, SNP, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Transforming Growth Factor beta1, PTPN22, 03 medical and health sciences, Rheumatology, medicine, Humans, Genetic Predisposition to Disease, [INFO]Computer Science [cs], Tumor Necrosis Factor alpha-Induced Protein 3, Aged, 030304 developmental biology, 030203 arthritis & rheumatology, business.industry, medicine.disease, TNF Receptor-Associated Factor 1, Pharmacogenetics, Case-Control Studies, Immunology, business
Abstract

Objective: To evaluate the association between several candidate single-nucleotide polymorphisms (SNPs) and responsiveness to rituximab in patients with rheumatoid arthritis (RA). Methods: Sixty-three RA patients were included. Nine genes (13 SNPs) were subsequently analyzed, including those coding for cytokines involved in synovitis (IL10, LTA, TGF beta 1, TNF-alpha, TNF receptor II) and genes associated with RA susceptibility (-C5 TRAF1, STAT4, TNFAIP3 and PTPN22). Results: Forty-four patients were defined as responders and 19 as nonresponders. TGF beta 1 Codon 10 and TGF beta 1 Codon 25 SNPs were both associated with clinical response (probability to respond to treatment with the Codon 10 C/T genotype: OR = 1.6; P = 0.002, and with the Codon 25 G/C genotype: OR = 1.6; P = 0.025). The probability to be a responder when the TGF beta Codon10 C/T and TGF beta Codon 25 G/C genotypes were co-inherited, doubled (OR = 2.6; P = 0.008). Conclusion: The TGF beta 1 SNPs are associated with a good response to rituximab therapy and as such could be useful genetic biomarkers in predicting therapy outcome. (C) 2011 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.

Published
2012
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