166 results on '"Doornebosch, Pascal G."'
Search Results
2. Indocyanine green near-infrared fluorescence bowel perfusion assessment to prevent anastomotic leakage in minimally invasive colorectal surgery (AVOID): a multicentre, randomised, controlled, phase 3 trial
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Faber, Robin A, Meijer, Ruben P J, Droogh, Daphne H M, Jongbloed, Jasmijn J, Bijlstra, Okker D, Boersma, Fran, Braak, Jeffrey P B M, Meershoek-Klein Kranenbarg, Elma, Putter, Hein, Holman, Fabian A, Mieog, J Sven D, Neijenhuis, Peter A, van Staveren, Esther, Bloemen, Johanne G, Burger, Jacobus W A, Aukema, Tjeerd S, Brouwers, Mark A M, Marinelli, Andreas W K S, Westerterp, Marinke, Doornebosch, Pascal G, van der Weijde, Annelies, Bosscha, Koop, Handgraaf, Henricus J M, Consten, Esther C J, Sikkenk, Daan J, Burggraaf, Jacobus, Keereweer, Stijn, van der Vorst, Joost R, Hutteman, Merlijn, Peeters, Koen C M J, Vahrmeijer, Alexander L, and Hilling, Denise E
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- 2024
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3. Extrahepatic perfusion and incomplete hepatic perfusion after hepatic arterial infusion pump implantation: incidence and clinical implications
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Filipe, Wills F., Buisman, Florian Buismanz, Koerkamp, Bas Groot, Grunhagen, Dirk J., Homs, Marjolein Y.V., Verhoef, Cornelis, Moelker, Adriaan, Graven, Laura, Franssen, Stijn, Gobardhan, Paul D., Loosveld, Olaf J.L., Pool, Stefan, Mieog, J. Sven D., Speetjens, Frank M., Rietbergen, Daphne D.D., Burgmans, Mark C., Doornesbosch, Pascal G., Patijn, Gijs A., de Groot, Jan Willem B., Meier, Mark A.J., Oostdijk, Ad H.J., Boluis, Karen, Grootscholten, Cecile, klompenhouwer, Elizabeth G., Kok, Niels F.M., kuhlmann, Koert, F.D., Krul, Myrtle F., Versleijen, Michelle W.J., Bruijnen, Rutger C.G., Hagendoorn, Jroen, Lam, Marnix G.E.H., Roodhart, Jeanine M.L., Bennink, Roel J., van Delden, Otto M., Swijnenburg, Rutger-Jan, Buffart, Tineke E., Borel Rinkes, Inne H.M., Cercek, Andrea, Kemeny, Nancy E., Peter Kingham, T., D’Angelica, Michael, van Bommel, Christian P.H., van Doorn, Leni, Ayez, Ninos, Vermaas, Maarten, Nieuwenhuijse, Vincent B., Buisman, Florian E., Grünhagen, Dirk J., Bolhuis, Karen, Doornebosch, Pascal G., Hagendoorn, Jeroen, Harmsen, Paul, Klompenhouwer, Elizabeth G., Outmani, Loubna, Swijnenburg, Rutger Jan, Kuhlmann, Koert F.D., and Groot Koerkamp, Bas
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- 2024
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4. Trends and overall survival after combined liver resection and thermal ablation of colorectal liver metastases: a nationwide population-based propensity score-matched study
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Buis, Carlijn I., Hagendoorn, Jeroen, Torrenga, Hans, van Heek, N. Tjarda, Braat, Andries E., Hoogwater, Frederik J.H., Consten, Esther C.J., van der Leij, Christiaan, Patijn, Gijs, de Graaff, Michelle R., Klaase, Joost M., den Dulk, Marcel, Coolsen, Marielle M.E., Kuhlmann, Koert F.D., Verhoef, Cees, Hartgrink, Henk H., Derksen, Wouter J.M., van den Boezem, Peter, Rijken, Arjen M., Gobardhan, Paul, Liem, Mike S.L., Leclercq, Wouter K.G., Marsman, Hendrik A., van Duijvendijk, Peter, Bosscha, Koop, Elfrink, Arthur K.E., Manusama, Eric R., Belt, Eric J. Th., Doornebosch, Pascal G., Oosterling, Steven J., Ruiter, Simeon J.S., Grünhagen, Dirk J., Burgmans, Mark, Meijerink, Martijn, Kok, Niels F.M., and Swijnenburg, Rutger-Jan
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- 2024
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5. Systemic exposure of floxuridine after hepatic arterial infusion pump chemotherapy with floxuridine in patients with resected colorectal liver metastases
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IJzerman, Nikki S., Filipe, Wills F., Bruijn, Peter de, Buisman, Florian E., Doorn, Leni van, Doornebosch, Pascal G., Holster, Jessica J., Grootscholten, Cecile, Grünhagen, Dirk J., van Bommel, Christian P.E., Homs, Marjolein Y.V., Kok, Niels F.M., Verhoef, Cornelis, Koerkamp, Bas Groot, Kuhlmann, Koert F.D., Mathijssen, Ron H.J., and Koolen, Stijn L.W.
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- 2023
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6. Risk of recurrence after local resection of T1 rectal cancer: a meta-analysis with meta-regression
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Dekkers, Nik, Dang, Hao, van der Kraan, Jolein, le Cessie, Saskia, Oldenburg, Philip P., Schoones, Jan W., Langers, Alexandra M. J., van Leerdam, Monique E., van Hooft, Jeanin E., Backes, Yara, Levic, Katarina, Meining, Alexander, Saracco, Giorgio M., Holman, Fabian A., Peeters, Koen C. M. J., Moons, Leon M. G., Doornebosch, Pascal G., Hardwick, James C. H., and Boonstra, Jurjen J.
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- 2022
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7. GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells
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Rakké, Yannick S., Campos Carrascosa, Lucia, van Beek, Adriaan A., de Ruiter, Valeska, van Gemerden, Rachelle S., Doukas, Michail, Doornebosch, Pascal G., Vermaas, Maarten, ter Borg, Susan, van der Harst, Erwin, Coene, Peter Paul L.O., Kliffen, Mike, Grünhagen, Dirk J., Verhoef, Cornelis, IJzermans, Jan N.M., Kwekkeboom, Jaap, and Sprengers, Dave
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- 2023
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8. Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort
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Greijdanus, Nynke G., Wienholts, Kiedo, Ubels, Sander, Talboom, Kevin, Hannink, Gerjon, Wolthuis, Albert, de Lacy, Francisco B., Lefevre, Jérémie H., Solomon, Michael, Frasson, Matteo, Rotholtz, Nicolas, Denost, Quentin, Perez, Rodrigo O., Konishi, Tsuyoshi, Panis, Yves, Rutegård, Martin, Hompes, Roel, Rosman, Camiel, van Workum, Frans, Tanis, Pieter J., de Wilt, Johannes H.W., Bremers, Andreas J.A., Ferenschild, Floris T., de Vriendt, Stefanie, D’Hoore, André, Bislenghi, Gabriele, Farguell, Jordi, Lacy, Antonio M., Atienza, Paula González, van Kessel, Charlotte S., Parc, Yann, Voron, Thibault, Collard, Maxime K., Muriel, Jorge Sancho, Cholewa, Hannia, Mattioni, Laura A., Frontali, Alice, Polle, Sebastiaan W., Polat, Fatih, Obihara, Ndidi J., Vailati, Bruna B., Kusters, Miranda, Tuynmann, Jurriaan B., Hazen, Sanne J.A., Grüter, Alexander A.J., Amano, Takahiro, Fujiwara, Hajime, Salomon, Mario, Ruiz, Hernán, Gonzalez, Ricardo, Estefanía, Diego, Avellaneda, Nicolas, Carrie, Augusto, Santillan, Mateo, Pantoja Pachajoa, Diana A., Parodi, Matias, Gielis, Manuel, Binder, Alf-Dorian, Gürtler, Thomas, Riedl, Peter, Badiani, Sarit, Berney, Christophe, Morgan, Matthew, Hollington, Paul, da Silva, Nigel, Nair, Gavin, Ho, Yiu M., Lamparelli, Michael, Kapadia, Raj, Kroon, Hidde M., Dudi-Venkata, Nagendra N., Liu, Jianliang, Sammour, Tarik, Flamey, Nicolas, Pattyn, Paul, Chaoui, Ahmed, Vansteenbrugge, Louis, van den Broek, Nathalie E.J., Vanclooster, Patrick, de Gheldere, Charles, Pletinckx, Pieter, Defoort, Barbara, Dewulf, Maxime, Slavchev, Mihail, Belev, Nikolay, Atanasov, Boyko, Krastev, Panche, Sokolov, Manol, Maslyankov, Svilen, Gribnev, Petar, Pavlov, Vasil, Ivanov, Tsvetomir, Karamanliev, Martin, Filipov, Emil, Tonchev, Pencho, Aigner, Felix, Mitteregger, Martin, Allmer, Caterina, Seitinger, Gerald, Colucci, Nicola, Buchs, Nicolas, Ris, Frédéric, Toso, Christian, Gialamas, Eleftherios, Vuagniaux, Aurélie, Chautems, Roland, Sauvain, Marc-Olivier, Daester, Silvio, von Flüe, Markus, Guenin, Marc-Olivier, Taha-Mehlitz, Stephanie, Hess, Gabriel F., Martínek, Lubomír, Skrovina, Matej, Machackova, Maria, Benčurik, Vladimir, Uluk, Deniz, Pratschke, Johann, Dittrich, Luca S., Guel-Klein, Safak, Perez, Daniel, Grass, Julia-Kristin, Melling, Nathaniel, Mueller, Simone, Iversen, Lene H., Eriksen, Jacob D., Baatrup, Gunnar, Al-Najami, Issam, Bjørsum-Meyer, Thomas, Teras, Jüri, Teras, Roland M., Monib, Fatma A., Abu Elnga Ahmed, Nagm Eldin, Alkady, Eithar, Ali, Ahmed K., Khedr, Gehan Abd Elatti, Abdelaal, Ahmed Samir, Bassyouni Ashoush, Fouad M., Ewedah, Moataz, Elshennawy, Eslam M., Hussein, Mohamed, Fernández-Martínez, Daniel, García-Flórez, Luis J., Fernández-Hevia, María, Suárez-Sánchez, Aida, del Hoyo Aretxabala, Izaskun, Docampo, Iria Losada, Zabala, Jesús Gómez, Tejedor, Patricia, Morales Bernaldo de Quirós, Javier T., Quiroga, Ignacio Bodega, Navarro-Sánchez, Antonio, Darias, Iván Soto, Fernández, Cristina López, de La Cruz Cuadrado, Cristina, Sánchez-Guillén, Luis, López-Rodríguez-Arias, Francisco, Soler-Silva, Álvaro, Arroyo, Antonio, Bernal-Sprekelsen, Juan C., Gómez-Abril, Segundo Á., Gonzálvez, Paula, Torres, María T., Sánchez, Teresa Rubio, Antona, Francisco Blanco, Sánchez Lara, Juan E., Alcázar Montero, José A., Fernández-Martínez, Daniel, García-Flórez, Luis J., Fernández-Hevia, María, Suárez-Sánchez, Aida, Colás-Ruiz, Enrique, Tasende-Presedo, Marta M., Fernández-Hurtado, Ignacio, Cifuentes-Ródenas, José A., Suárez, Marta Castro, Losada, Manuel, Hernández, Miguel, Alonso, Alfredo, Diéguez, Beatriz, Serralta, Daniel, Medina Quintana, Rita E., Gil Lopez, Jose M., Pinto, Francisca Lima, Nieto-Moreno, Elena, Bonito, Alba Correa, Santacruz, Carlos Cerdán, Marcos, Elena Bermejo, Septiem, Javier García, Calero-Lillo, Aránzazu, Alanez-Saavedra, Javier, Muñoz-Collado, Salvador, López-Lara, Manuel, Martínez, María Labalde, Herrero, Eduardo Ferrero, Borda, Francisco Javier García, Villar, Óscar García, Escartín, Jorge, Blas, Juan L., Ferrer, Rocío, Egea, Jorge García, Rodríguez-Infante, Antonio, Mínguez-Ruiz, Germán, Carreño-Villarreal, Guillermo, Pire-Abaitua, Gerardo, Dziakova, Jana, Rodríguez, Carlos Sáez-Cazallas, Pizarro Aranda, María J., Muguerza Huguet, José M., Borda-Arrizabalaga, Nerea, Enriquez-Navascués, José M., Echaniz, Garazi Elorza, Ansorena, Yolanda Saralegui, Estaire-Gómez, Mercedes, Martínez-Pinedo, Carlos, Barbero-Valenzuela, Alejandro, Ruíz-García, Pablo, Kraft, Miquel, Gómez-Jurado, María J., Pellino, Gianluca, Espín-Basany, Eloy, Cotte, Eddy, Panel, Nathalie, Goutard, Claire-Angéline, deÁngelis, Nicola, Lauka, Lelde, Shaikh, Shafaque, Osborne, Laura, Ramsay, George, Nichita, Vladimir-Ion, Bhandari, Santosh, Sarmah, Panchali, Bethune, Rob M., Pringle, Heather C.M., Massey, Lisa, Fowler, George E., Hamid, Hytham K.S., de Simone, Belinda D., Kynaston, James, Bradley, Nicholas, Stienstra, Roxane M., Gurjar, Shashank, Mukherjee, Tanmoy, Chandio, Ashfaq, Ahmed, Safia, Singh, Baljit, Runau, Francois, Chaudhri, Sanjay, Siaw, Oliver, Sarveswaran, Janahan, Miu, Victor, Ashmore, Daniel, Darwich, Haitham, Singh-Ranger, Deepak, Singh, Nirbhaibir, Shaban, Mohamed, Gareb, Fahed, Petropolou, Thalia, Polydorou, Adreas, Dattani, Mit, Afzal, Asma, Bavikatte, Akshay, Sebastian, Boby, Ward, Nicholas, Mishra, Amitabh, Manatakis, Dimitrios, Agalianos, Christos, Tasis, Nikolaos, Antonopoulou, Maria-Ioanna, Karavokyros, Ioannis, Charalabopoulos, Alexandros, Schizas, Dimitrios, Baili, Efstratia, Syllaios, Athanasios, Karydakis, Lysandros, Vailas, Michail, Balalis, Dimitrios, Korkolis, Dimitrios, Plastiras, Aris, Rompou, Aliki, Xenaki, Sofia, Xynos, Evangelos, Chrysos, Emmanuel, Venianaki, Maria, Christodoulidis, Grigorios, Perivoliotis, Konstantinos, Tzovaras, George, Baloyiannis, Ioannis, Ho, Man-Fung, Ng, Simon Siu-man, Mak, Tony Wing-chung, Futaba, Kaori, Šantak, Goran, Šimleša, Damir, osić, Jurica, Zukanović, Goran, Kelly, Michael E., Larkin, John O., McCormick, Paul H., Mehigan, Brian J., Connelly, Tara M., Neary, Peter, Ryan, Jessica, McCullough, Peter, Al-Juaifari, Maytham A., Hammoodi, Hayder, Abbood, Ali Hashim, Calabrò, Marcello, Muratore, Andrea, Terra, Antonio La, Farnesi, Francesca, Feo, Carlo V., Fabbri, Nicolò, Pesce, Antonio, Fazzin, Marta, Roscio, Francesco, Clerici, Federico, Lucchi, Andrea, Vittori, Laura, Agostinelli, Laura, Ripoli, Maria Cristina, Sambucci, Daniele, Porta, Andrea, Sinibaldi, Giovanni, Crescentini, Giacomo, larcinese, Antonella, Picone, Emanuele, Persiani, Roberto, Biondi, Alberto, Pezzuto, Roberto, Lorenzon, Laura, Rizzo, Gianluca, Coco, Claudio, D’Agostino, Luca, Spinelli, Antonino, Sacchi, Matteo M., Carvello, Michele, Foppa, Caterina, Spinelli, Antonino, Sacchi, Matteo M., Carvello, Michele, Foppa, Caterina, Maroli, Annalisa, Palini, Gian M., Garulli, Gianluca, Zanini, Nicola, Delrio, Paolo, Rega, Daniela, Carbone, Fabio, Aversano, Alessia, Pirozzolo, Giovanni, Recordare, Alfonso, DʼAlimonte, Lucrezia, Vignotto, Chiara, Corbellini, Carlo, Sampietro, Gianluca M., Lorusso, Leonardo, Manzo, Carlo A., Ghignone, Federico, Ugolini, Giampaolo, Montroni, Isacco, Pasini, Franceso, Pasini, Francesco, Ballabio, Michele, Bisagni, Pietro, Armao, Francesca T., Longhi, Marco, Ghazouani, Omar, Galleano, Raffaele, Tamini, Nicolò, Oldani, Massimo, Nespoli, Luca, Picciariello, Arcangelo, Altomare, Donato F., Tomasicchio, Giovanni, Lantone, Giuliano, Catena, Fausto, Giuffrida, Mario, Annicchiarico, Alfredo, Perrone, Gennaro, Grossi, Ugo, Santoro, Giulio A., Zanus, Giacomo, Iacomino, Alessandro, Novello, Simone, Passuello, Nicola, Zucchella, Martino, Puca, Lucia, deGiuli, Maurizio, Reddavid, Rossella, Scabini, Stefano, Aprile, Alessandra, Soriero, Domenico, Fioravanti, Emanuela, Rottoli, Matteo, Romano, Angela, Tanzanu, Marta, Belvedere, Angela, Mariani, Nicolò M., Ceretti, Andrea P., Opocher, Enrico, Gallo, Gaetano, Sammarco, Giuseppe, de Paola, Gilda, Pucciarelli, Salvatore, Marchegiani, Francesco, Spolverato, Gaya, Buzzi, Gianluca, Di Saverio, Salomone, Meroni, Paola, Parise, Cristiano, Bottazzoli, Elisa I., Lapolla, Pierfrancesco, Brachini, Gioia, Cirillo, Bruno, Mingoli, Andrea, Sica, Giuseppe, Siragusa, Leandro, Bellato, Vittoria, Cerbo, Daniele, de Pasqual, Carlo A., de Manzoni, Giovanni, di Cosmo, Maria A., Alrayes, Bourhan M.H., Qandeel, Mahmoud W. M., Hani, Mohammad Bani, Rabadi, Alexander, el Muhtaseb, Mohammad S., Abdeen, Basel, Karmi, Fahed, Žilinskas, Justas, Latkauskas, Tadas, Tamelis, Algimantas, Pikūnienė, Ingrida, Šlenfuktas, Vygintas, Poskus, Tomas, Kryzauskas, Marius, Jakubauskas, Matas, Mikalauskas, Saulius, Jakubauskiene, Lina, Hassan, Soha Y., Altrabulsi, Amani, Abdulwahed, Eman, Ghmagh, Reem, Deeknah, Abdulqudus, Alshareea, Entisar, Elhadi, Muhammed, Abujamra, Saleh, Msherghi, Ahmed A., Tababa, Osama W.E., Majbar, Mohammed A., Souadka, Amine, Benkabbou, Amine, Mohsine, Raouf, Echiguer, Sabrillah, Moctezuma-Velázquez, Paulina, Salgado-Nesme, Noel, Vergara-Fernández, Omar, Sainz-Hernández, Juan C., Alvarez-Bautista, Francisco E., Zakaria, Andee D., Zakaria, Zaidi, Wong, Michael P.K., Ismail, Razif, Ibrahim, Aini F., Abdullah, Nik A.N., Julaihi, Rokayah, Bhat, Sameer, OʼGrady, Greg, Bissett, Ian, Lamme, Bas, Musters, Gijsbert D., Dinaux, Anne M., Grotenhuis, Brechtje A., Steller Arend G.J. Aalbers, Ernst J., Leeuwenburgh, Marjolein M., Rutten, Harm J.T., Burger, Jacobus W.A., Bloemen, Johanne G., Ketelaers, Stijn H.J., Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, Talsma, Aaldert K., Scheurink, Lieke, van Praagh, Jasper B., Segelman, Josefin, Nygren, Jonas, Anderin, Kajsa, Tiefenthal, Marit, de Andrés, Beatriz, Beltrán de Heredia, Juan P., Vázquez, Andrea, Gómez, Tania, Golshani, Parisa, Kader, Rawaz, Mohamed, Abudi, Westerterp, Marinke, Marinelli, Andreas, Niemer, Quirine, Doornebosch, Pascal G., Shapiro, Joël, Vermaas, Maarten, de Graaf, Eelco J.R., van Westreenen, Hendrik L., Zwakman, Marije, van Dalsen, Annette D., Vles, Wouter J., Nonner, Joost, Toorenvliet, Boudewijn R., Janssen, Paul T.J., Verdaasdonk, Emiel G.G., Amelung, Femke J., Peeters Renu R. Bahadoer, Koen C.M.J., Holman, Fabian A., Heemskerk, Jeroen, Vosbeek, Noortje, Leijtens, Jeroen W.A., Taverne, Sophie B.M., Heijnen, Bob H.M., El-Massoudi, Youssef, de Groot-van Veen, Irene, Hoff, Christiaan, Jou-Valencia, Daniela, Consten, Esther C.J., Burghgraef, Thijs A., Geitenbeek, Ritch, Hulshof, Lorenzo G.W.L., Slooter, Gerrit D., Reudink, Muriël, Bouvy, Nicole D., Wildeboer, Aurelia C. L., Verstappen, Sonja, Pennings, Alexander J., van den Hengel, Berber, Wijma, Allard G., de Haan, Jael, de Nes, Lindsey C.F., Heesink, Vera, Karsten, Tom, Heidsma, Charlotte M., Koemans, Willem J., Dekker, Jan-Willem T., van der Zijden, Charlène J., Roos, Daphne, Demirkiran, Ahmet, van der Burg, Sjirk, Oosterling, Steven J., Hoogteijling, Tijs J., Wiering, Bastiaan, Smeeing, Diederik P.J., Havenga, Klaas, Lutfi, Hamid, Consten, Esther C.J., Tsimogiannis, Konstantinos, Sköldberg, Filip, Folkesson, Joakim, den Boer, Frank, van Schaik, Ted G., van Gerven, Pieter, Sietses, Colin, Hol, Jeroen C., Boerma, Evert-Jan G., Creemers, Davy M.J., Schultz, Johannes K., Frivold, Tone, Riis, Rolf, Gregussen, Hilde, Busund, Sondre, Sjo, Ole H., Gaard, Maria, Krohn, Nina, Ersryd, Amanda L., Leung, Edmund, Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, Sultan, Hytham, Hajjaj, Baraa Nabil, Alhisi, Ahmed Jehad, Khader, Ahmed A.E., Mendes, Ana Filipa Dias, Semião, Miguel, Faria, Luis Queiroz, Azevedo, Constança, da Costa Devesa, Helena M., Martins, Sónia Fortuna, Rodrigues Jarimba, Aldo M., Ribeiro Marques, Sónia M., Ferreira, Rita Marques, Oliveira, António, Ferreira, Cátia, Pereira, Ricardo, Surlin, Valeriu M., Graure, Giorgiana M., Ramboiu, Stefan Patrascu Sandu D., Negoi, Ionut, Ciubotaru, Cezar, Stoica, Bogdan, Tanase, Ioan, Stoica, Bogdan, Ciubotaru, Cezar, Negoita, Valentina M., Florea, Sabrina, Macau, Florin, Vasile, Mihai, Stefanescu, Victor, Dimofte, Gabriel-Mihail, Luncă, Sorinel, Roată, Cristian-Ene, Mu[Latin Small Letter s with comma below]ină, Ana-Maria, Garmanova, Tatiana, Agapov, Mikhail N., Markaryan, Daniil G., Eduard, Galliamov, Yanishev, Alexey, Abelevich, Alexander, Bazaev, Andrey, Rodimov, Sergey V., Filimonov, Victor B., Melnikov, Andrey A., Suchkov, Igor A., Drozdov, EvgeniyS., Kostromitskiy, Dmitriy N., Sjöström, Olle, Matthiessen, Peter, Baban, Bayar, Gadan, Soran, Jadid, Kaveh Dehlaghi, Staffan, Maria, Park, Jennifer M., Rydbeck, Daniel, Lydrup, Marie-Louise, Buchwald, Pamela, Jutesten, Henrik, Darlin, Lotten, Lindqvist, Ebba, Nilsson, Karl, Larsson, Per-Anders, Jangmalm, Staffan, Košir, Jurij A., Tomažič, Aleš, Grosek, Jan, Božič, Tajda Košir, Zazo, Aya, Zazo, Rama, Fares, Hala, Ayoub, Kusay, Niazi, Ammar, Mansour, Ali, Abbas, Ayman, Tantoura, Mohammad, Hamdan, Alaa, Hassan, Naya, Hasan, Bassam, Saad, Ahmad, Sebai, Amine, Haddad, Anis, Maghrebi, Houcine, Kacem, Montasser, Yalkın, Ömer, Samsa, Mehmet Veysi, Atak, İbrahim, Balci, Bengi, Haberal, Elifcan, Dogan, Lütfi, Gecim, Ibrahim E., Akyol, Cihangir, Koc, Mehmet A., Sivrikoz, Emre, Piyadeoğlu, Deniz, Larkin, John O., avanagh, Dara O., Sökmen, Selman, Bişgin, Tayfun, Günenç, Erşan, Güzel, Melek, Leventoğlu, Sezai, Yüksel, Osman, Kozan, Ramazan, Göbüt, Hüseyin, Cengiz, Fevzi, Erdinc, Kemal, Acar, Nihan Coşgun, Kamer, Erdinc, Özgür, İlker, Aydın, Oguzhan, Keskin, Metin, Bulut, Mehmet Türker, Kulle, Cemil B., Kara, Yasin, Sıbıç, Osman, Özata, İbrahim H., Buğra, Dursun, Balık, Emre, Kulle, Cemil B., Çakır, Murat, Alhardan, Anas, Colak, Elif, CiftciEngin Aybar, Ahmet B., Sari, Ahmet Can, Atici, Semra Demirli, Kaya, Tayfun, Dursun, Ayberk, Calik, Bulent, Özkan, Ömer Faruk, Ülgür, Hanife Şeyda, Düzgün, Özgül, Monson, John, George, Sarah, Woods, Kayla, Al-Eryani, Fatima, Albakry, Rudaina, Coetzee, Emile, Boutall, Adam, Herman, Ayesiga, Warden, Claire, Mugla, Naser, Forgan, Tim, Mia, Imraan, and Lambrechts, Anton
- Published
- 2023
- Full Text
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9. T1 colorectal cancer patients' perspective on information provision and therapeutic decision‐making after local resection
- Author
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Dekkers, Nik, Dang, Hao, Graaf, Manon, Nobbenhuis, Kate, Verhoeven, Daan A., Kraan, Jolein, Vos tot Nederveen Cappel, Wouter H., Alkhalaf, Alaa, Westreenen, Henderik L., Basiliya, Kirill, Peeters, Koen C. M. J., Westerterp, Marinke, Doornebosch, Pascal G., Hardwick, James C. H., Langers, Alexandra M. J., and Boonstra, Jurjen J.
- Abstract
Decision‐making after local resection of T1 colorectal cancer (T1CRC) is often complex and calls for optimal information provision as well as active patient involvement. The aim was to evaluate the perceptions of patients with T1CRC on information provision and therapeutic decision‐making. This multicenter cross‐sectional study included patients who underwent endoscopic or local surgical resection as initial treatment. Information provision was assessed using the EORTC QLQ‐INFO25 questionnaire. In patients with high‐risk T1CRC, we evaluated decisional involvement and satisfaction regarding the choice as to whether to undergo additional treatment after local resection, and the level of decisional conflict using the Decisional Conflict Scale. Ninety‐eight patients with T1CRC were included (72% response rate; 79/98 endoscopic and 19/98 local surgical resection; 45/98 high‐risk T1CRC). Median time since local resection was 28 months (IQR 18); none had developed recurrence. Unmet information needs were reported by 29 patients (30%; 18 low‐risk, 11 high‐risk), mostly on post‐treatment related topics (follow‐up visits, recovery time, recurrence prevention). After local resection, 24 of the 45 high‐risk patients (53%) underwent additional treatment, while others were subjected to surveillance. Higher‐educated patients were more often actively involved in decision‐making (93% vs. 43%, p= 0.002) and more frequently underwent additional treatment (79% vs. 40%, p= 0.02). Decisional conflict (p= 0.19) and satisfaction (p= 0.78) were comparable between higher‐ and lower‐educated high‐risk patients. Greater attention should be given to the post‐treatment course during consultations following local T1CRC resection. The differences in decisional involvement and selected management strategies between higher‐ and lower‐educated high‐risk patients warrant further investigation.
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- 2024
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10. The association of Cognitive Coping Style with Patient Preferences in a Patient- Led Follow-Up Study among Colorectal Cancer Survivors
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Voigt, Kelly R., primary, Wullaert, Lissa, additional, Driel, M. H. Elise van, additional, Goudberg, Max, additional, Doornebosch, Pascal G., additional, Schreinemakers, Jennifer M.J., additional, Verseveld, Maria, additional, Peeters, Koen C.M.J., additional, Verhoef, Cornelis, additional, Husson, Olga, additional, and Grünhagen, Dirk J., additional
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- 2024
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11. Trends and overall survival after combined liver resection and thermal ablation of colorectal liver metastases:a nationwide population-based propensity score-matched study
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de Graaff, Michelle R., Klaase, Joost M., den Dulk, Marcel, Coolsen, Marielle M.E., Kuhlmann, Koert F.D., Verhoef, Cees, Hartgrink, Henk H., Derksen, Wouter J.M., van den Boezem, Peter, Rijken, Arjen M., Gobardhan, Paul, Liem, Mike S.L., Leclercq, Wouter K.G., Marsman, Hendrik A., van Duijvendijk, Peter, Bosscha, Koop, Elfrink, Arthur K.E., Manusama, Eric R., Belt, Eric J.Th, Doornebosch, Pascal G., Oosterling, Steven J., Ruiter, Simeon J.S., Grünhagen, Dirk J., Burgmans, Mark, Meijerink, Martijn, Kok, Niels F.M., Swijnenburg, Rutger Jan, Buis, Carlijn I., Hagendoorn, Jeroen, Torrenga, Hans, van Heek, N. Tjarda, Braat, Andries E., Hoogwater, Frederik J.H., Consten, Esther C.J., van der Leij, Christiaan, Patijn, Gijs, de Graaff, Michelle R., Klaase, Joost M., den Dulk, Marcel, Coolsen, Marielle M.E., Kuhlmann, Koert F.D., Verhoef, Cees, Hartgrink, Henk H., Derksen, Wouter J.M., van den Boezem, Peter, Rijken, Arjen M., Gobardhan, Paul, Liem, Mike S.L., Leclercq, Wouter K.G., Marsman, Hendrik A., van Duijvendijk, Peter, Bosscha, Koop, Elfrink, Arthur K.E., Manusama, Eric R., Belt, Eric J.Th, Doornebosch, Pascal G., Oosterling, Steven J., Ruiter, Simeon J.S., Grünhagen, Dirk J., Burgmans, Mark, Meijerink, Martijn, Kok, Niels F.M., Swijnenburg, Rutger Jan, Buis, Carlijn I., Hagendoorn, Jeroen, Torrenga, Hans, van Heek, N. Tjarda, Braat, Andries E., Hoogwater, Frederik J.H., Consten, Esther C.J., van der Leij, Christiaan, and Patijn, Gijs
- Abstract
Background: In colorectal liver metastases (CRLM) patients, combination of liver resection and ablation permit a more parenchymal-sparing approach. This study assessed trends in use of combined resection and ablation, outcomes, and overall survival (OS). Methods: This population-based study included all CRLM patients who underwent liver resection between 2014 and 2022. To assess OS, data was linked to two databases containing date of death for patients treated between 2014 and 2018. Hospital variation in the use of combined minor liver resection and ablation versus major liver resection alone in patients with 2–3 CRLM and ≤3 cm was assessed. Propensity score matching (PSM) was applied to evaluate outcomes. Results: This study included 3593 patients, of whom 1336 (37.2%) underwent combined resection and ablation. Combined resection increased from 31.7% in 2014 to 47.9% in 2022. Significant hospital variation (range 5.9–53.8%) was observed in the use of combined minor liver resection and ablation. PSM resulted in 1005 patients in each group. Major morbidity was not different (11.6% vs. 5%, P = 1.00). Liver failure occurred less often after combined resection and ablation (1.9% vs. 0.6%, P = 0.017). Five-year OS rates were not different (39.3% vs. 33.9%, P = 0.145). Conclusion: Combined resection and ablation should be available and considered as an alternative to resection alone in any patient with multiple metastases.
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- 2024
12. Extrahepatic perfusion and incomplete hepatic perfusion after hepatic arterial infusion pump implantation:incidence and clinical implications
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Filipe, Wills F, Buisman, Florian E, Franssen, Stijn, Krul, Myrtle F, Grünhagen, Dirk J, Bennink, Roel J, Bolhuis, Karen, Bruijnen, Rutger C G, Buffart, Tineke E, Burgmans, Mark C, van Delden, Otto M, Doornebosch, Pascal G, Gobardhan, Paul D, Graven, Laura, de Groot, Jan Willem B, Grootscholten, Cecile, Hagendoorn, Jeroen, Harmsen, Paul, Homs, Marjolein Y V, Klompenhouwer, Elizabeth G, Kok, Niels F M, Lam, Marnix G E H, Loosveld, Olaf J L, Meier, Mark A J, Mieog, J Sven D, Oostdijk, Ad H J, Outmani, Loubna, Patijn, Gijs A, Pool, Stefan, Rietbergen, Daphne D D, Roodhart, Jeanine M L, Speetjens, Frank M, Swijnenburg, Rutger Jan, Versleijen, Michelle W J, Verhoef, Cornelis, Kuhlmann, Koert F D, Moelker, Adriaan, Groot Koerkamp, Bas, Filipe, Wills F, Buisman, Florian E, Franssen, Stijn, Krul, Myrtle F, Grünhagen, Dirk J, Bennink, Roel J, Bolhuis, Karen, Bruijnen, Rutger C G, Buffart, Tineke E, Burgmans, Mark C, van Delden, Otto M, Doornebosch, Pascal G, Gobardhan, Paul D, Graven, Laura, de Groot, Jan Willem B, Grootscholten, Cecile, Hagendoorn, Jeroen, Harmsen, Paul, Homs, Marjolein Y V, Klompenhouwer, Elizabeth G, Kok, Niels F M, Lam, Marnix G E H, Loosveld, Olaf J L, Meier, Mark A J, Mieog, J Sven D, Oostdijk, Ad H J, Outmani, Loubna, Patijn, Gijs A, Pool, Stefan, Rietbergen, Daphne D D, Roodhart, Jeanine M L, Speetjens, Frank M, Swijnenburg, Rutger Jan, Versleijen, Michelle W J, Verhoef, Cornelis, Kuhlmann, Koert F D, Moelker, Adriaan, and Groot Koerkamp, Bas
- Abstract
INTRODUCTION: This study investigates the incidence of extrahepatic perfusion and incomplete hepatic perfusion at intraoperative methylene blue testing and on postoperative nuclear imaging in patients undergoing hepatic arterial infusion pump (HAIP) chemotherapy.METHODS:The first 150 consecutive patients who underwent pump implantation in the Netherlands were included. All patients underwent surgical pump implantation with the catheter in the gastroduodenal artery. All patients underwent intraoperative methylene blue testing and postoperative nuclear imaging ( 99mTc-Macroaggregated albumin SPECT/CT) to determine perfusion via the pump. RESULTS: Patients were included between January-2018 and December-2021 across eight centers. During methylene blue testing, 29.3% had extrahepatic perfusion, all successfully managed intraoperatively. On nuclear imaging, no clinically relevant extrahepatic perfusion was detected (0%, 95%CI: 0.0-2.5%). During methylene blue testing, 2.0% had unresolved incomplete hepatic perfusion. On postoperative nuclear imaging, 8.1% had incomplete hepatic perfusion, leading to embolization in only 1.3%.CONCLUSION: Methylene blue testing during pump placement for intra-arterial chemotherapy identified extrahepatic perfusion in 29.3% of patients, but could be resolved intraoperatively in all patients. Postoperative nuclear imaging found no clinically relevant extrahepatic perfusion and led to embolization in only 1.3% of patients. The role of routine nuclear imaging after HAIP implantation should be studied in a larger cohort.
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- 2024
13. Implementation and outcome of minor and major minimally invasive liver surgery in the Netherlands
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Zonderhuis, Babs, Rinkes, Inne B., Hoff, Christiaan, Oosterling, Steven, van der Poel, Marcel J., Fichtinger, Robert S., Bemelmans, Marc, Bosscha, Koop, Braat, Andries E., de Boer, Marieke T., Dejong, Cornelis H.C., Doornebosch, Pascal G., Draaisma, Werner A., Gerhards, Michael F., Gobardhan, Paul D., Gorgec, Burak, Hagendoorn, Jeroen, Kazemier, Geert, Klaase, Joost, Leclercq, Wouter K.G., Liem, Mike S., Lips, Daan J., Marsman, Hendrik A., Mieog, J. Sven D., Molenaar, Quintus I., Nieuwenhuijs, Vincent B., Nota, Carolijn L., Patijn, Gijs A., Rijken, Arjen M., Slooter, Gerrit D., Stommel, Martijn W.J., Swijnenburg, Rutger-Jan, Tanis, Pieter J., te Riele, Wouter W., Terkivatan, Türkan, van den Tol, Petrousjka M., van den Boezem, Peter B., van der Hoeven, Joost A., Vermaas, Maarten, Abu Hilal, Moh'd, van Dam, Ronald M., and Besselink, Marc G.
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- 2019
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14. Trends and overall survival after combined liver resection and thermal ablation of colorectal liver metastases: a nationwide population-based propensity score-matched study
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de Graaff, Michelle R., primary, Klaase, Joost M., additional, den Dulk, Marcel, additional, Coolsen, Marielle M.E., additional, Kuhlmann, Koert F.D., additional, Verhoef, Cees, additional, Hartgrink, Henk H., additional, Derksen, Wouter J.M., additional, van den Boezem, Peter, additional, Rijken, Arjen M., additional, Gobardhan, Paul, additional, Liem, Mike S.L., additional, Leclercq, Wouter K.G., additional, Marsman, Hendrik A., additional, van Duijvendijk, Peter, additional, Bosscha, Koop, additional, Elfrink, Arthur K.E., additional, Manusama, Eric R., additional, Belt, Eric J. Th., additional, Doornebosch, Pascal G., additional, Oosterling, Steven J., additional, Ruiter, Simeon J.S., additional, Grünhagen, Dirk J., additional, Burgmans, Mark, additional, Meijerink, Martijn, additional, Kok, Niels F.M., additional, Swijnenburg, Rutger-Jan, additional, Buis, Carlijn I., additional, Hagendoorn, Jeroen, additional, Torrenga, Hans, additional, van Heek, N. Tjarda, additional, Braat, Andries E., additional, Hoogwater, Frederik J.H., additional, Consten, Esther C.J., additional, van der Leij, Christiaan, additional, and Patijn, Gijs, additional
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- 2024
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15. The occurrence and characteristics of endoscopically unexpected malignant degeneration in large rectal adenomas
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Bemelman, Willem A., Bijnen, Bart, Bisschops, Raf, van den Broek, Frank J.C., Davids, Paul, Depla, Annekatrien, van Dullemen, Hendrik, Hardwick, James C., Hoff, Chrisiaan, Houben, Martin, Jansen, Jeroen M., Gerhards, Michael F., van der Linde, Klaas, van Milligen de Wit, A.W. Marc, Mallant, Rosalie, van der Schelling, George P., Timmer, Robin, Witteman, Ben, Weusten, Bas L.A.M., Wolthuis, Albert, Bronzwaer, Maxime E.S., Musters, Gijsbert D., Barendse, Renée M., Koens, Lianne, de Graaf, Eelco J.R., Doornebosch, Pascal G., Schwartz, Matthijs P., Consten, Esther C.J., Schoon, Erik J., de Hingh, Ignace H.J.T., Tanis, Pieter J., Dekker, Evelien, and Fockens, Paul
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- 2018
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16. B cell immune profiles in dysbiotic vermiform appendixes of pancreatic cancer patients
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Vietsch, Eveline E., primary, Latifi, Diba, additional, Verheij, Maaike, additional, van der Oost, Elise W.A., additional, de Wilde, Roeland F., additional, Haen, Roel, additional, van den Boom, Anne Loes, additional, Koerkamp, Bas Groot, additional, Doornebosch, Pascal G., additional, van Verschuer, Victorien M.T., additional, Ooms, Ariadne H.A.G., additional, Mohammad, Farzana, additional, Willemsen, Marcella, additional, Aerts, Joachim G.J.V., additional, Krog, Ricki T., additional, de Miranda, Noel F.C.C., additional, van den Bosch, Thierry P.P., additional, Mueller, Yvonne M., additional, Katsikis, Peter D., additional, and van Eijck, Casper H.J., additional
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- 2023
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17. Patient-led home-based follow-up after surgery for colorectal cancer: the protocol of the prospective, multicentre FUTURE-primary implementation study
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Voigt, Kelly Raquel, primary, Wullaert, Lissa, additional, Höppener, Diederik J, additional, Schreinemakers, Jennifer M J, additional, Doornebosch, Pascal G, additional, Verseveld, Maria, additional, Peeters, Koen, additional, Verhoef, Cornelis, additional, Husson, Olga, additional, and Grünhagen, Dirk, additional
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- 2023
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18. Outcome of Completion Surgery after Endoscopic Submucosal Dissection in Early-Stage Colorectal Cancer Patients
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Dekkers, Nik, primary, Dang, Hao, additional, Vork, Katinka, additional, Langers, Alexandra M. J., additional, van der Kraan, Jolein, additional, Westerterp, Marinke, additional, Peeters, Koen C. M. J., additional, Holman, Fabian A., additional, Koch, Arjun D., additional, de Graaf, Wilmar, additional, Didden, Paul, additional, Moons, Leon M. G., additional, Doornebosch, Pascal G., additional, Hardwick, James C. H., additional, and Boonstra, Jurjen J., additional
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- 2023
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19. Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial
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Nauth, Aaron, Creek, Aaron T., Zellar, Abby, Lawendy, Abdel-Rahman, Dowrick, Adam, Gupta, Ajay, Dadi, Akhil, van Kampen, Albert, Yee, Albert, de Vries, Alexander C., de Mol van Otterloo, Alexander, Garibaldi, Alisha, Liew, Allen, McIntyre, Allison W., Prasad, Amal Shankar, Romero, Amanda W., Rangan, Amar, Oatt, Amber, Sanghavi, Amir, Foley, Amy L., Karlsten, Anders, Dolenc, Andrea, Bucknill, Andrew, Chia, Andrew, Evans, Andrew, Gong, Andrew, Schmidt, Andrew H., Marcantonio, Andrew J., Jennings, Andrew, Ward, Angela, Khanna, Angshuman, Rai, Anil, Smits, Anke B., Horan, Annamarie D., Brekke, Anne Christine, Flynn, Annette, Duraikannan, Aravin, Stødle, Are, van Vugt, Arie B., Luther, Arlene, Zurcher, Arthur W., Jain, Arvind, Amundsen, Asgeir, Moaveni, Ash, Carr, Ashley, Sharma, Ateet, Hill, Austin D., Trommer, Axel, Rai, B. Sachidananda, Hileman, Barbara, Schreurs, Bart, Verhoeven, Bart, Barden, Benjamin B., Flatøy, Bernhard, Cleffken, Berry I., Bøe, Berthe, Perey, Bertrand, Hanusch, Birgit C., Weening, Brad, Fioole, Bram, Rijbroek, Bram, Crist, Brett D., Halliday, Brett, Peterson, Brett, Mullis, Brian, Richardson, C. Glen, Clark, Callum, Sagebien, Carlos A., van der Pol, Carmen C., Bowler, Carol, Humphrey, Catherine A., Coady, Catherine, Koppert, Cees L., Coles, Chad, Tannoury, Chadi, DePaolo, Charles J., Gayton, Chris, Herriott, Chris, Reeves, Christina, Tieszer, Christina, Dobb, Christine, Anderson, Christopher G., Sage, Claire, Cuento, Claudine, Jones, Clifford B., Bosman, Coks H.R., Linehan, Colleen, van der Hart, Cor P., Henderson, Corey, Lewis, Courtland G., Davis, Craig A., Donohue, Craig, Mauffrey, Cyril, Sundaresh, D.C., Farrell, Dana J., Whelan, Daniel B., Horwitz, Daniel, Stinner, Daniel, Viskontas, Darius, Roffey, Darren M., Alexander, David, Karges, David E., Hak, David, Johnston, David, Love, David, Wright, David M., Zamorano, David P., Goetz, David R., Sanders, David, Stephen, David, Yen, David, Bardana, Davide, Olakkengil, Davy J, Lawson, Deanna, Maddock, Deborah, Sietsema, Debra L., Pourmand, Deeba, Den Hartog, Dennis, Donegan, Derek, Heels-Ansdell, Diane, Nam, Diane, Inman, Dominic, Boyer, Dory, Li, Doug, Gibula, Douglas, Price, Dustin M., Watson, Dylan J., Hammerberg, E. Mark, Tan, Edward T.C.H., de Graaf, Eelco J.R., Vesterhus, Elise Berg, Roper, Elizabeth, Edwards, Elton, Schemitsch, Emil H., Hammacher, Eric R., Henderson, Eric R., Whatley, Erica, Torres, Erick T., Vermeulen, Erik G.J., Finn, Erin, Van Lieshout, Esther M.M., Wai, Eugene K., Bannister, Evan R., Kile, Evelyn, Theunissen, Evert B.M., Ritchie, Ewan D., Khan, Farah, Moola, Farhad, Howells, Fiona, de Nies, Frank, van der Heijden, Frank H.W.M., de Meulemeester, Frank R.A.J., Frihagen, Frede, Nilsen, Fredrik, Schmidt, G. Ben, Albers, G.H. Robert, Gudger, Garland K., Jr, Johnson, Garth, Gruen, Gary, Zohman, Gary, Sharma, Gaurav, Wood, Gavin, Tetteroo, Geert W.M., Hjorthaug, Geir, Jomaas, Geir, Donald, Geoff, Rieser, Geoffrey Ryan, Reardon, Gerald, Slobogean, Gerard P., Roukema, Gert R, Visser, Gijs A., Moatshe, Gilbert, Horner, Gillian, Rose, Glynis, Guyatt, Gordon, Chuter, Graham, Etherington, Greg, Rocca, Gregory J. Della, Ekås, Guri, Dobbin, Gwendolyn, Lemke, H. Michael, Curry, Hamish, Boxma, Han, Gissel, Hannah, Kreder, Hans, Kuiken, Hans, Brom, Hans L.F., Pape, Hans-Christoph, van der Vis, Harm M, Bedi, Harvinder, Vallier, Heather A., Brien, Heather, Silva, Heather, Newman, Heike, Viveiros, Helena, van der Hoeven, Henk, Ahn, Henry, Johal, Herman, Rijna, Herman, Stockmann, Heyn, Josaputra, Hong A., Carlisle, Hope, van der Brand, Igor, Dawson, Imro, Tarkin, Ivan, Wong, Ivan, Parr, J. Andrew, Trenholm, J. Andrew, Goslings, J. Carel, Amirault, J. David, Broderick, J. Scott, Snellen, Jaap P., Zijl, Jacco A.C., Ahn, Jaimo, Ficke, James, Irrgang, James, Powell, James, Ringler, James R., Shaer, James, Monica, James T., Biert, Jan, Bosma, Jan, Brattgjerd, Jan Egil, Frölke, Jan Paul M., Wille, Jan, Rajakumar, Janakiraman, Walker, Jane E., Baker, Janell K., Ertl, Janos P., de Vries, Jean Paul P.M., Gardeniers, Jean W.M., May, Jedediah, Yach, Jeff, Hidy, Jennifer T., Westberg, Jerald R., Hall, Jeremy A., van Mulken, Jeroen, McBeth, Jessica Cooper, Hoogendoorn, Jochem, Hoffman, Jodi M., Cherian, Joe Joseph, Tanksley, John A., Jr., Clarke-Jenssen, John, Adams, John D., Esterhai, John, Tilzey, John F., Murnaghan, John, Ketz, John P., Garfi, John S., Schwappach, John, Gorczyca, John T., Wyrick, John, Rydinge, Jonas, Foret, Jonathan L., Gross, Jonathan M., Keeve, Jonathan P., Meijer, Joost, Scheepers, Joris J.G., Baele, Joseph, O'Neil, Joseph, Cass, Joseph R., Hsu, Joseph R., Dumais, Jules, Lee, Julia, Switzer, Julie A., Agel, Julie, Richards, Justin E., Langan, Justin W., Turckan, Kahn, Pecorella, Kaili, Rai, Kamal, Aurang, Kamran, Shively, Karl, van Wessem, Karlijn, Moon, Karyn, Eke, Kate, Erwin, Katie, Milner, Katrine, Ponsen, Kees Jan, Mills, Kelli, Apostle, Kelly, Johnston, Kelly, Trask, Kelly, Strohecker, Kent, Stringfellow, Kenya, Kruse, Kevin K., III, Tetsworth, Kevin, Mitchell, Khalis, Browner, Kieran, Hemlock, Kim, Carcary, Kimberly, Jørgen Haug, Knut, Noble, Krista, Robbins, Kristin, Payton, Krystal, Jeray, Kyle J., Rubino, L. Joseph, Nastoff, Lauren A., Leffler, Lauren C., Stassen, Laurents P.S., O'Malley, Lawrence K., II, Specht, Lawrence M., Thabane, Lehana, Geeraedts, Leo M.G., Shell, Leslie E., Anderson, Linda K., Eickhoff, Linda S., Lyle, Lindsey, Pilling, Lindsey, Buckingham, Lisa, Cannada, Lisa K., Wild, Lisa M., Dulaney-Cripe, Liz, Poelhekke, Lodewijk M.S.J., Govaert, Lonneke, Ton, Lu, Kottam, Lucksy, Leenen, Luke P.H., Clipper, Lydia, Jackson, Lyle T., Hampton, Lynne, de Waal Malefijt, Maarten C., Simons, Maarten P., van der Elst, Maarten, Bronkhorst, Maarten W.G.A., Bhatia, Mahesh, Swiontkowski, Marc, Lobo, Margaret J., Swinton, Marilyn, Pirpiris, Marinis, Molund, Marius, Gichuru, Mark, Glazebrook, Mark, Harrison, Mark, Jenkins, Mark, MacLeod, Mark, de Vries, Mark R., Butler, Mark S., Nousiainen, Markku, van 't Riet, Martijne, Tynan, Martin C., Campo, Martin, Eversdijk, Martin G., Heetveld, Martin J., Richardson, Martin, Breslin, Mary, Fan, Mary, Edison, Matt, Napierala, Matthew, Knobe, Matthias, Russ, Matthias, Zomar, Mauri, de Brauw, Maurits, Esser, Max, Hurley, Meghan, Peters, Melissa E., Lorenzo, Melissa, Li, Mengnai, Archdeacon, Michael, Biddulph, Michael, Charlton, Michael, McDonald, Michael D., McKee, Michael D., Dunbar, Michael, Torchia, Michael E., Gross, Michael, Hewitt, Michael, Holt, Michael, Prayson, Michael J., Edwards, Michael J.R., Beckish, Michael L., Brennan, Michael L., Dohm, Michael P., Kain, Michael S.H., Vogt, Michelle, Yu, Michelle, Verhofstad, Michiel H.J., Segers, Michiel J.M., Siroen, Michiel P.C., Reed, Mike, Vicente, Milena R., Bruijninckx, Milko M.M., Trivedi, Mittal, Bhandari, Mohit, Moore, Molly M., Kunz, Monica, Smedsrud, Morten, Palla, Naveen, Jain, Neeraj, Out, Nico J.M., Simunovic, Nicole, Schep, Niels W.L., Müller, Oliver, Guicherit, Onno R., Van Waes, Oscar J.F., Wang, Otis, Doornebosch, Pascal G., Seuffert, Patricia, Hesketh, Patrick J., Weinrauch, Patrick, Duffy, Paul, Keller, Paul, Lafferty, Paul M., Pincus, Paul, Tornetta, Paul, III, Zalzal, Paul, McKay, Paula, Cole, Peter A., de Rooij, Peter D., Hull, Peter, Go, Peter M.N.Y.M., Patka, Peter, Siska, Peter, Weingarten, Peter, Kregor, Philip, Stahel, Philip, Stull, Philip, Wittich, Philippe, de Rijcke, Piet A.R., Oprel, Pim, Devereaux, PJ, Zhou, Qi, Lee Murphy, R., Jr., Alosky, Rachel, Clarkson, Rachel, Moon, Raely, Logishetty, Rajanikanth, Nanda, Rajesh, Sullivan, Raymond J., Snider, Rebecca G., Buckley, Richard E., Iorio, Richard, Farrugia, Richard J, Jenkinson, Richard, Laughlin, Richard, Groenendijk, Richard P.R., Gurich, Richard W., Jr, Worman, Ripley, Silvis, Rob, Haverlag, Robert, Teasdall, Robert J., Korley, Robert, McCormack, Robert, Probe, Robert, Cantu, Robert V., Huff, Roger B., Simmermacher, Rogier K.J., Peters, Rolf, Pfeifer, Roman, Liem, Ronald, Wessel, Ronald N., Verhagen, Ronald, Vuylsteke, Ronald, Leighton, Ross, McKercher, Ross, Poolman, Rudolf W., Miller, Russell, Bicknell, Ryan, Finnan, Ryan, Khan, Ryan M., Mehta, Samir, Vang, Sandy, Singh, Sanjay, Anand, Sanjeev, Anderson, Sarah A., Dawson, Sarah A., Marston, Scott B., Porter, Scott E., Watson, Scott T., Festen, Sebastiaan, Lieberman, Shane, Puloski, Shannon, Bielby, Shea A., Sprague, Sheila, Hess, Shelley, MacDonald, Shelley, Evans, Simone, Bzovsky, Sofia, Hasselund, Sondre, Lewis, Sophie, Ugland, Stein, Caminiti, Stephanie, Tanner, Stephanie L., Zielinski, Stephanie M., Shepard, Stephanie, Sems, Stephen A., Walter, Stephen D., Doig, Stephen, Finley, Stephen H., Kates, Stephen, Lindenbaum, Stephen, Kingwell, Stephen P., Csongvay, Steve, Papp, Steve, Buijk, Steven E., Rhemrev, Steven J., Hollenbeck, Steven M., van Gaalen, Steven M., Yang, Steven, Weinerman, Stuart, Subash, Lambert, Sue, Liew, Susan, Meylaerts, Sven A.G., Blokhuis, Taco J., de Vries Reilingh, Tammo S., Lona, Tarjei, Scott, Taryn, Swenson, Teresa K., Endres, Terrence J., Axelrod, Terry, van Egmond, Teun, Pace, Thomas B., Kibsgård, Thomas, Schaller, Thomas M., Ly, Thuan V., Miller, Timothy J., Weber, Timothy, Le, Toan, Oliver, Todd M., Karsten, Tom M., Borch, Tor, Hoseth, Tor Magne, Nicolaisen, Tor, Ianssen, Torben, Rutherford, Tori, Nanney, Tracy, Gervais, Trevor, Stone, Trevor, Schrickel, Tyson, Scrabeck, Tyson, Ganguly, Utsav, Naumetz, V., Frizzell, Valda, Wadey, Veronica, Jones, Vicki, Avram, Victoria, Mishra, Vimlesh, Yadav, Vineet, Arora, Vinod, Tyagi, Vivek, Borsella, Vivian, Willems, W. Jaap, Hoffman, W.H., Gofton, Wade T., Lackey, Wesley G., Ghent, Wesley, Obremskey, William, Oxner, William, Cross, William W., III, Murtha, Yvonne M., and Murdoch, Zoe
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- 2017
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20. Perineal wound closure using gluteal turnover flap or primary closure after abdominoperineal resection for rectal cancer: study protocol of a randomised controlled multicentre trial (BIOPEX-2 study)
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Sharabiany, Sarah, Blok, Robin D., Lapid, Oren, Hompes, Roel, Bemelman, Wilhelmus A., Alberts, Victor P., Lamme, Bas, Wijsman, Jan H., Tuynman, Jurriaan B., Aalbers, Arend G. J., Beets, Geerard L., Fabry, Hans F. J., Cherepanin, Ivan M., Polat, Fatih, Burger, Jacobus W. A., Rutten, Harm J. T., Bosker, Robert J. I., Talsma, Koen, Rothbarth, Joost, Verhoef, Cees, van de Ven, Anthony W. H., van der Bilt, Jarmila D. W., de Graaf, Eelco J. R., Doornebosch, Pascal G., Leijtens, Jeroen W. A., Heemskerk, Jeroen, Singh, Baljit, Chaudhri, Sanjay, Gerhards, Michael F., Karsten, Tom M., de Wilt, Johannes H. W., Bremers, Andre J. A., Vuylsteke, Ronald J. C. L. M., Heuff, Gijsbert, van Geloven, Anna A. W., Tanis, Pieter J., and Musters, Gijsbert D.
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- 2020
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21. Transanal minimally invasive surgery (TAMIS) versus endoscopic submucosal dissection (ESD) for resection of non-pedunculated rectal lesions (TRIASSIC study): study protocol of a European multicenter randomised controlled trial
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Dekkers, Nik, Boonstra, Jurjen J., Moons, Leon M. G., Hompes, Roel, Bastiaansen, Barbara A., Tuynman, Jurriaan B., Koch, Arjun D., Weusten, Bas L. A. M., Pronk, Apollo, Neijenhuis, Peter A., Westerterp, Marinke, van den Hout, Wilbert B., Langers, Alexandra M. J., van der Kraan, Jolein, Alkhalaf, Alaa, Lai, Jonathan Y. L., ter Borg, Frank, Fabry, Hans, Halet, Eric, Schwartz, Matthijs P., Nagengast, Wouter B., Straathof, Jan Willem A., ten Hove, Rogier W. R., Oterdoom, Leendert H., Hoff, Christiaan, Belt, Eric J Th, Zimmerman, David D. E., Hadithi, Muhammed, Morreau, Hans, de Cuba, Erienne M. V., Leijtens, Jeroen W. A., Vasen, Hans F. A., van Leerdam, Monique E., de Graaf, Eelco J. R., Doornebosch, Pascal G., and Hardwick, James C. H.
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- 2020
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22. Patient-led home-based follow-up after surgery for colorectal cancer:the protocol of the prospective, multicentre FUTURE-primary implementation study
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Voigt, Kelly Raquel, Wullaert, Lissa, Höppener, Diederik J., Schreinemakers, Jennifer M.J., Doornebosch, Pascal G., Verseveld, Maria, Peeters, Koen, Verhoef, Cornelis, Husson, Olga, Grünhagen, Dirk, Voigt, Kelly Raquel, Wullaert, Lissa, Höppener, Diederik J., Schreinemakers, Jennifer M.J., Doornebosch, Pascal G., Verseveld, Maria, Peeters, Koen, Verhoef, Cornelis, Husson, Olga, and Grünhagen, Dirk
- Abstract
INTRODUCTION: Colorectal cancer (CRC) is the third most common type of cancer in the Netherlands. Approximately 90% of patients can be treated with surgery, which is considered potentially curative. Postoperative surveillance during the first 5 years after surgery pursues to detect metastases in an early, asymptomatic and treatable stage. Multiple large randomised controlled trials have failed to show any (cancer-specific) survival benefit of intensive postoperative surveillance compared with a minimalistic approach in patients with CRC. This raises the question whether an (intensive) in-hospital postoperative surveillance strategy is still warranted from both a patient well-being and societal perspective. A more modern, home-based surveillance strategy could be beneficial in terms of patients' quality of life and healthcare costs. METHODS AND ANALYSIS: The multicentre, prospective FUTURE-primary study implements a patient-led home-based surveillance after curative CRC treatment. Here, patients are involved in the choice regarding three fundamental aspects of their postoperative surveillance. First regarding frequency, patients can opt for additional follow-up moments to the minimal requirement as outlined by the current Dutch national guidelines. Second regarding the setting, both in-hospital or predominantly home-based options are available. And third, concerning patient-doctor communication choices ranging from in-person to video chat, and even silent check-ups. The aim of the FUTURE-primary study is to evaluate if such a patient-led home-based follow-up approach is successful in terms of quality of life, satisfaction and anxiety compared with historic data. A successful implementation of the patient-led aspect will be assessed by the degree in which the additional, optional follow-up moments are actually utilised. Secondary objectives are to evaluate quality of life, anxiety, fear of cancer recurrence and cost-effectiveness.
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- 2023
23. Outcome of Completion Surgery after Endoscopic Submucosal Dissection in Early-Stage Colorectal Cancer Patients
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Dekkers, Nik, Dang, Hao, Vork, Katinka, Langers, Alexandra M.J., van der Kraan, Jolein, Westerterp, Marinke, Peeters, Koen C.M.J., Holman, Fabian A., Koch, Arjun D., de Graaf, Wilmar, Didden, Paul, Moons, Leon M.G., Doornebosch, Pascal G., Hardwick, James C.H., Boonstra, Jurjen J., Dekkers, Nik, Dang, Hao, Vork, Katinka, Langers, Alexandra M.J., van der Kraan, Jolein, Westerterp, Marinke, Peeters, Koen C.M.J., Holman, Fabian A., Koch, Arjun D., de Graaf, Wilmar, Didden, Paul, Moons, Leon M.G., Doornebosch, Pascal G., Hardwick, James C.H., and Boonstra, Jurjen J.
- Abstract
T1 colorectal cancers (T1CRC) are increasingly being treated by endoscopic submucosal dissection (ESD). After ESD of a T1CRC, completion surgery is indicated in a subgroup of patients. Currently, the influence of ESD on surgical morbidity and mortality is unknown. The aim of this study was to compare 90-day morbidity and mortality of completion surgery after ESD to primary surgery. The completion surgery group consisted of suspected T1CRC patients from a multicenter prospective ESD database (2014–2020). The primary surgery group consisted of pT1CRC patients from a nationwide surgical registry (2017–2019). Patients with rectal or sigmoidal cancers were selected. Patients receiving neoadjuvant therapy were excluded. Propensity score adjustment was used to correct for confounders. In total, 411 patients were included: 54 in the completion surgery group (39 pT1, 15 pT2) and 357 in the primary surgery group with pT1CRC. Adverse event rate was 24.1% after completion surgery and 21.3% after primary surgery. After completion surgery 90-day mortality did not occur, though one patient died in the primary surgery group. After propensity score adjustment, lymph node yield did not differ significantly between the groups. Among other morbidity-related outcomes, stoma rate (OR 1.298 95%-CI 0.587-2.872, p = 0.519) and adverse event rate (OR 1.162; 95%-CI 0.570-2.370, p = 0.679) also did not differ significantly. A subgroup analysis was performed in patients undergoing rectal surgery. In this subgroup (37 completion and 136 primary surgery), these morbidity outcomes also did not differ significantly. In conclusion, this study suggests that ESD does not compromise morbidity or 90-day mortality of completion surgery.
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- 2023
24. Systemic exposure of floxuridine after hepatic arterial infusion pump chemotherapy with floxuridine in patients with resected colorectal liver metastases
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IJzerman, Nikki S, Filipe, Wills F, Bruijn, Peter de, Buisman, Florian E, Doorn, Leni van, Doornebosch, Pascal G, Holster, Jessica J, Grootscholten, Cecile, Grünhagen, Dirk J, van Bommel, Christian P E, Homs, Marjolein Y V, Kok, Niels F M, Verhoef, Cornelis, Koerkamp, Bas Groot, Kuhlmann, Koert F D, Mathijssen, Ron H J, Koolen, Stijn L W, IJzerman, Nikki S, Filipe, Wills F, Bruijn, Peter de, Buisman, Florian E, Doorn, Leni van, Doornebosch, Pascal G, Holster, Jessica J, Grootscholten, Cecile, Grünhagen, Dirk J, van Bommel, Christian P E, Homs, Marjolein Y V, Kok, Niels F M, Verhoef, Cornelis, Koerkamp, Bas Groot, Kuhlmann, Koert F D, Mathijssen, Ron H J, and Koolen, Stijn L W
- Abstract
BACKGROUND: Floxuridine's high hepatic extraction ratio and short elimination half-life allows maximum liver exposure with minimal systemic side-effects. This study attempts to quantify the systemic exposure of floxuridine.METHODS: Patients undergoing continuous hepatic arterial infusion pump (HAIP) floxuridine after resection of colorectal liver metastases (CRLM) in two centres underwent six cycles of floxuridine at start dose 0.12 mg/kg/day. No concomitant systemic chemotherapy was administered. Peripheral venous blood samples were drawn during the first two cycles: pre-dose (only in the second cycle), 30 min, 1 h, 2 h, 7 h, and 15 days after floxuridine infusion. Foxuridine concentration in the residual pump reservoir was measured on day 15 of both cycles. A floxuridine assay with a lower boundary of detection of 0.250 ng/mL was developed.RESULTS: 265 blood samples were collected in the 25 patient included in this study. Floxuridine was mostly measurable at day 7 and day 15 (86 % and 88 % of patients respectively). The median dose corrected concentrations were 0.607 ng/mL [IQR: 0.472-0.747] for cycle 1 day 7, 0.579 ng/mL [IQR: 0.470-0.693] for cycle 1 day 15, 0.646 ng/mL [IQR: 0.463-0.8546] for cycle 2 day 7, and 0.534 ng/mL [IQR: 0.4257-0.7075] for cycle 2 day 15. One patient had remarkably high floxuridine concentrations reaching up to 44 ng/mL during the second cycle, without a clear explanation. The floxuridine concentration in the pump decreased by 14.7 % (range 0.5 %-37.8 %) over a period of 15 days (n = 18).CONCLUSION: Overall, negligible systemic concentrations of floxuridine were detected. However, remarkably increased levels were detected in one patient. Floxuridine concentration in the pump decreases over time.
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- 2023
25. GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells
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Rakké, Yannick S, Campos Carrascosa, Lucia, van Beek, Adriaan A, de Ruiter, Valeska, van Gemerden, Rachelle S, Doukas, Michail, Doornebosch, Pascal G, Vermaas, Maarten, Ter Borg, Susan, van der Harst, Erwin, Coene, Peter Paul L O, Kliffen, Mike, Grünhagen, Dirk J, Verhoef, Cornelis, IJzermans, Jan N M, Kwekkeboom, Jaap, Sprengers, Dave, Rakké, Yannick S, Campos Carrascosa, Lucia, van Beek, Adriaan A, de Ruiter, Valeska, van Gemerden, Rachelle S, Doukas, Michail, Doornebosch, Pascal G, Vermaas, Maarten, Ter Borg, Susan, van der Harst, Erwin, Coene, Peter Paul L O, Kliffen, Mike, Grünhagen, Dirk J, Verhoef, Cornelis, IJzermans, Jan N M, Kwekkeboom, Jaap, and Sprengers, Dave
- Abstract
BACKGROUND & AIMS: In contrast to mismatch repair deficient colorectal carcinoma (CRC), MMR proficient (pMMR) CRC does not respond to immune checkpoint blockade. We studied immune checkpoint stimulation via glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) on ex vivo functionality of human tumor-infiltrating lymphocytes (TIL) isolated from pMMR primary CRC and liver metastases (CRLM).METHODS: Using lymphocytes from resected tumor, adjacent tissues, and peripheral blood mononuclear cells (PBMC) of 132 pMMR primary CRC or CRLM patients, we determined GITR expression and the in vitro T-cell agonistic activity of recombinant GITR ligation.RESULTS: Here, we show that GITR was overexpressed on TIL when compared with other stimulatory immune checkpoints (4-1BB, OX40). Its expression was enhanced in TIL compared with PBMC and adjacent tissues. Among CD4 + TIL, GITR expression was primarily expressed by CD45RA - FoxP3 hi activated regulatory T cells. Within CD8 + TIL, GITR was predominantly expressed on functionally exhausted and putative tumor-reactive CD103 + CD39 + TIL. Strikingly, recombinant GITRL reinvigorated ex vivo TIL responses by significantly enhancing CD4 + and CD8 + TIL numbers. Dual treatment with GITRL and nivolumab (anti-PD1) enhanced CD8 + TIL expansion compared with GITRL monotherapy. Moreover, GITRL/anti-PD1 dual therapy further improved anti-PD1-mediated reinvigoration of interferon gamma secretion by exhausted CD8 TIL from primary CRC. CONCLUSIONS: GITR is overexpressed on CD4 + and CD8 + TIL from pMMR CRC and CRLM. Agonistic targeting of GITR enhances ex vivo human TIL functionality and may therefore be a promising approach for novel monotherapy or combined immunotherapies in primary pMRR CRC and CRLM.
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- 2023
26. Outcome of Completion Surgery after Endoscopic Submucosal Dissection in Early-Stage Colorectal Cancer Patients
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MS MDL 1, Cancer, Dekkers, Nik, Dang, Hao, Vork, Katinka, Langers, Alexandra M.J., van der Kraan, Jolein, Westerterp, Marinke, Peeters, Koen C.M.J., Holman, Fabian A., Koch, Arjun D., de Graaf, Wilmar, Didden, Paul, Moons, Leon M.G., Doornebosch, Pascal G., Hardwick, James C.H., Boonstra, Jurjen J., MS MDL 1, Cancer, Dekkers, Nik, Dang, Hao, Vork, Katinka, Langers, Alexandra M.J., van der Kraan, Jolein, Westerterp, Marinke, Peeters, Koen C.M.J., Holman, Fabian A., Koch, Arjun D., de Graaf, Wilmar, Didden, Paul, Moons, Leon M.G., Doornebosch, Pascal G., Hardwick, James C.H., and Boonstra, Jurjen J.
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- 2023
27. Supplementary Table from Progression and Tumor Heterogeneity Analysis in Early Rectal Cancer
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Lips, Esther H., primary, van Eijk, Ronald, primary, de Graaf, Eelco J.R., primary, Doornebosch, Pascal G., primary, de Miranda, Noel F.C.C., primary, Oosting, Jan, primary, Karsten, Tom, primary, Eilers, Paul H.C., primary, Tollenaar, Rob A.E.M., primary, van Wezel, Tom, primary, and Morreau, Hans, primary
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- 2023
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28. Transanal endoscopic surgery for complications of prior rectal surgery
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van Vledder, Mark G., Doornebosch, Pascal G., and de Graaf, Eelco J. R.
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- 2016
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29. Transanal minimally invasive surgery: impact on quality of life and functional outcome
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Verseveld, Maria, Barendse, Renée M., Gosselink, Martijn P., Verhoef, Cornelis, de Graaf, Eelco J. R., and Doornebosch, Pascal G.
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- 2016
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30. Laparoscopic Rectovaginopexy for Neorectal Prolapse After Transanal Total Mesorectal Excision
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Shapiro, Joel, de Graaf, Joris J.J.C., Doornebosch, Pascal G., Vermaas, Maarten, and de Graaf, Eelco J.R.
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- 2018
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31. RECURRENCE AFTER LOCAL SURGICAL RESECTION OF T1 RECTAL CANCER: A META-ANALYSIS AND COMPARISON WITH ENDOSCOPIC RESECTION
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Dekkers, Nik, primary, Dang, Hao, additional, van der Kraan, Jolein, additional, Le Cessie, Saskia, additional, Oldenburg, Philip P., additional, Schoones, Jan W., additional, Langers, Alexandra M., additional, Van Leerdam, Monique, additional, Van Hooft, Jeanin E., additional, Backes, Yara, additional, Levic, Katarina, additional, Meining, Alexander, additional, Saracco, Giorgio, additional, Holman, Fabian A., additional, Peeters, Koen, additional, Moons, L.M.G., additional, Doornebosch, Pascal G., additional, Hardwick, James, additional, and Boonstra, Jurjen, additional
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- 2022
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32. Risk of recurrence after local resection of T1 rectal cancer: a meta-analysis with meta-regression
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MS MDL 1, Cancer, Dekkers, Nik, Dang, Hao, van der Kraan, Jolein, le Cessie, Saskia, Oldenburg, Philip P, Schoones, Jan W, Langers, Alexandra M J, van Leerdam, Monique E, van Hooft, Jeanin E, Backes, Yara, Levic, Katarina, Meining, Alexander, Saracco, Giorgio M, Holman, Fabian A, Peeters, Koen C M J, Moons, Leon M G, Doornebosch, Pascal G, Hardwick, James C H, Boonstra, Jurjen J, MS MDL 1, Cancer, Dekkers, Nik, Dang, Hao, van der Kraan, Jolein, le Cessie, Saskia, Oldenburg, Philip P, Schoones, Jan W, Langers, Alexandra M J, van Leerdam, Monique E, van Hooft, Jeanin E, Backes, Yara, Levic, Katarina, Meining, Alexander, Saracco, Giorgio M, Holman, Fabian A, Peeters, Koen C M J, Moons, Leon M G, Doornebosch, Pascal G, Hardwick, James C H, and Boonstra, Jurjen J
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- 2022
33. Intramucosal carcinoma of the rectum can be safely treated with transanal endoscopic microsurgery; clinical support of the revised Vienna classification
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Verseveld, Maria, Barendse, Renée M., Dawson, Imro, Vos, Elvira L., de Graaf, Eelco J. R., and Doornebosch, Pascal G.
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- 2014
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34. Reliability, Validity, and Responsiveness of the Western Ontario and McMaster Universities Osteoarthritis Index for Elderly Patients with a Femoral Neck Fracture
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Burgers, Paul T.P.W., Poolman, Rudolf W, Van Bakel, Theodorus MJ, Tuinebreijer, Wim E, Zielinski, Stephanie M, Bhandari, Mohit, Patka, Peter, Van Lieshout, Esther MM, Bhandari, Mohit, Devereaux, P J, Guyatt, Gordon H, Einhorn, Thomas A, Thabane, Lehana, Schemitsch, Emil H, Koval, Kenneth J, Frihagen, Frede, Poolman, Rudolf W, Tetsworth, Kevin, Guerra-Farfan, Ernesto, Walter, Stephen D, Sprague, Sheila, Swinton, Marilyn, Scott, Taryn, McKay, Paula, Madden, Kim, Heels-Ansdell, Diane, Buckingham, Lisa, Duraikannan, Aravin, Silva, Heather, Heetveld, Martin J, Van Lieshout, Esther MM, Burgers, Paul T.P.W., Zura, Robert D, Avram, Victoria, Manjoo, Ajay, Williams, Dale, Antoniou, John, Ramsay, Tim, Bogoch, Earl R, Trenholm, Andrew, Lyman, Stephen, Mazumdar, Madhu, Bozic, Kevin J, Luborsky, Mark, Goodman, Stuart, Muray, Susan, Korley, Rob, Buckley, Richard, Duffy, Paul, Puloski, Shannon, Carcary, Kimberly, Lorenzo, Melissa, McKee, Michael D, Hall, Jeremy A, Nauth, Aaron, Whelan, Daniel, Daniels, Timothy R, Waddell, James P, Ahn, Henry, Vicente, Milena R, Hidy, Jennifer T, MacNevin, Melanie T, Kreder, Hans, Axelrod, Terry, Jenkinson, Richard, Nousiainen, Markku, Stephen, David, Wadey, Veronica, Kunz, Monica, Milner, Katrine, Cagaanan, Ria, MacNevin, Melanie, O’Brien, Peter J, Blachut, Piotr A, Broekhuyse, Henry M, Guy, Pierre, Lefaivre, Kelly A, Slobogean, Gerard P, Johal, Raman, Leung, Irene, Coles, Chad, Leighton, Ross, Richardson, C. Glen, Biddulph, Michael, Gross, Michael, Dunbar, Michael, Amirault, J. David, Alexander, David, Coady, Catherine, Glazebrook, Mark, Johnston, David, Oxner, William, Reardon, Gerald, Wong, Ivan, Trask, Kelly, MacDonald, Shelley, Furey, Andrew, Stone, Craig, Parsons, Minnie, Stone, Trevor, Zomar, Mauri, McCormack, Robert, Apostle, Kelly, Boyer, Dory, Moola, Farhad, Perey, Bertrand, Viskontas, Darius, Moon, Karyn, Moon, Raely, Laflamme, Yves, Benoit, Benoit, Ranger, Pierre, Malo, Michel, Fernandes, Julio, Tardif, Karine, Fournier, Julie, Vendittoli, Pascal André, Massé, Vincent, Roy, Alain G, Lavigne, Martin, Lusignan, Daniel, Davis, Craig, Stull, Philip, Weinerman, Stewart, Weingarten, Peter, Lindenbaum, Steven, Hewitt, Michael, Danielwicz, Rebecca, Baker, Janell, Mont, Michael, Delanois, Donald E, Kapadia, Bhaveen, Issa, Kimona, Mullen, Marylou, Sems, Andrew, Foreman, Barb, Parvizi, Javad, Morrison, Tiffany, Lewis, Courtland, Caminiti, Stephanie, Tornetta, Paul, III, Creevy, William R, Lespasio, Michelle J, Carlisle, Hope, Marcantonio, Andrew, Kain, Michael, Specht, Lawrence, Tilzey, John, Garfi, John, Mehta, Samir, Esterhai, John L, Jr., Ahn, Jaimo, Donegan, Derek, Horan, Annamarie, McGinnis, Kelly, Roberson, James, Bradbury, Thomas, Erens, Greg, Webb, Kyle, Mullis, Brian, Shively, Karl, Parr, Andrew, Ertl, Janos, Worman, Ripley, Webster, Mark, Cummings, Judd, Frizzell, Valda, Moore, Molly, Jones, Clifford B, Ringler, James R, Sietsema, Debra L, Walker, Jane E, Kanlic, Enes, Abdelgawad, Amr, Shunia, Juan, DePaolo, Charles, Sutherland, Susan, Alosky, Rachel, Zura, Robert, Manson, Maria, Strathy, Gregg, Peter, Kathleen, Johnson, Paul, Morton, Meaghan, Shaer, James, Schrickel, Tyson, Hileman, Barbara, Hanes, Marina, Chance, Elisha, Heinrich, E. Matthew, Dodgin, David, LaBadie, Michele, Zamorano, David, Tynan, Martin, Schwarzkopf, Ran, Scolaro, John A, Gupta, Ranjan, Bederman, Samuel, Bhatia, Nitin, Hoang, Bang, Kiester, Douglas, Jones, Neil, Rafijah, Gregory, Alavekios, Damon, Lee, Jason, Mehta, Akshay, Schroder, Steven, Chao, Tom, Colin, Vincent, Dang, Phuc (Phil), Heng, Stephen Keun, Lopez, Gregory, Galle, Samuel, Pahlavan, Sohrab, Phan, Duy L, Tapadia, Minal, Bui, Christopher, Jain, Nickul, Moore, Tyler, Moroski, Nathan, Pourmand, Deeba, Kubiak, Erik N, Gililland, Jeremy, Rothberg, David, Peters, Christopher, Pelt, Christopher, Stuart, Ami R, Corbey, Kirby, Shuler, Franklin D, Day, James, Garabekyan, Tigran, Cheung, Felix, Oliashirazi, Ali, Salava, Jonathon, Morgan, Linda, Wilson-Byrne, Timothy, Cordle, Mary Beth, Elmans, Leon H.G.J., van den Hout, Joost A.A.M., Joosten, Adrianus JP, van Beurden, Ad FA, Bolder, Stefan BT, Eygendaal, Denise, Moonen, Adrianus F.C.M., van Geenen, Rutger CI, Hoebink, Eric A, Wagenmakers, Robert, van Helden, Wouter, van Jonbergen, Hans-Peter W, Roerdink, Herbert, Reuver, Joost M, Barnaart, Alexander FW, Flikweert, Elvira R, Krips, Rover, Mullers, J. Bernard, Schüller, Hans, Falke, Mark LM, Kurek, Frans J, Slingerland, Adrianus CH, van Dijk, Jan P, van Helden, Wouter H, Bolhuis, Hugo W, Bullens, Pieter HJ, Hogervorst, Mike, de Kroon, Karin E, Jansen, Rob H, Steenstra, Ferry, Raven, Eric EJ, Fontijne, W. Peter J, Wiersma, Saskia C, Boetes, Bastiaan, ten Holder, Edgar JT, van der Heide, Huub JL, Nagels, Jochem, van der Linden-van der Zwaag, Enrike H.M.J., Keizer, Stefan B, Swen, Jan-Willem A, den Hollander, Peter HC, Thomassen, Bregje JW, Molekamp, Willem Jan Kleyn, de Meulemeester, Frank R.A.J., Kleipool, Arthur EB, Haverlag, Robert, Simons, Maarten P, Mutsaerts, Eduard L.A.R., Kooijman, Rob, Postema, Roelf R, Bleker, René J.T.M., Lampe, Harald IH, Schuman, Lein, Cheung, John, van Bommel, Frank, Winia, W. Paul, Haverkamp, Daniel, van der Vis, Harm, Nolte, Peter A, van den Bekerom, Michel PJ, de Jong, Tjitte, van Noort, Arthur, Vergroesen, Diederik A, Schutte, Bernard G, van der Vis, Harm M, Beimers, Lijkele, de Vries, Jasper, Zurcher, Arthur W, Albers, G.H. Rob, Rademakers, Maarten, Breugem, Stefan, van der Haven, Ibo, Jan Damen, Pieter, Bulstra, Gythe H, Campo, Martin M, Somford, Mathijs P, Haverkamp, Daniël, Liew, Susan, Bedi, Harvinder, Carr, Ashley, Chia, Andrew, Csongvay, Steve, Donohue, Craig, Doig, Stephen, Edwards, Elton, Esser, Max, Freeman, Richard, Gong, Andrew, Li, Doug, Miller, Russell, Ton, Lu, Wang, Otis, Young, Ian, Dowrick, Adam, Murdoch, Zoe, Sage, Claire, Page, Richard, Bainbridge, David, Angliss, Richard, Miller, Ben, Thomson, Andrew, Brown, Graeme, Williams, Simon, Eng, Kevin, Bowyer, David, Skelley, John, Goyal, Chatar, Beattie, Sally, Guerado, Enrique, Cruz, Encarnacion, Cano, Juan Ramon, Froufe, Miguel Angel, Serra, Lluis Marull, Al-dirra, Samer, Martinez, Cristina, Tarazona Santabalbina, Francisco José, Serra, Jordi Teixidor, Hernandez, Jordi Tomas, Garcia, Marc Aguilar, Garcia, Vicente Molero, Barrera, Sergi, Garrido, Miriam, Nordsletten, Lars, Clarke-Jenssen, John, Hjorthaug, Geir, Brekke, Anne Christine, Vesterhus, Elise Berg, Skaugrud, Ingunn, Tripathi, Pradeep, Katiyar, Sandesh, Shukla, Preksha, Swiontkowski, Marc, Guyatt, Gordon, Jeray, Kyle, Walter, Stephen, Viveiros, Helena, Truong, Victoria, Koo, Kaitlin, Zhou, Qi, Maddock, Deborah, Simunovic, Nicole, Agel, Julie, Zielinski, Stephanie M, Rangan, Amar, Hanusch, Birgit C, Kottam, Lucksy, Clarkson, Rachel, Della Rocca, Gregory J, Slobogean, Gerard, Katz, Jeffrey, Gillespie, Brenda, Greendale, Gail A, Hartman, Curtis, Rubin, Craig, Waddell, James, Lemke, H. Michael, Oatt, Amber, Buckley, Richard E, Korley, Robert, Johnston, Kelly, Powell, James, Sanders, David, Lawendy, Abdel, Tieszer, Christina, Murnaghan, John, Nam, Diane, Yee, Albert, Whelan, Daniel B, Wild, Lisa M, Khan, Ryan M, Coady, Cathy, Amirault, David, Richardson, Glen, Dobbin, Gwen, Bicknell, Ryan, Yach, Jeff, Bardana, Davide, Wood, Gavin, Harrison, Mark, Yen, David, Lambert, Sue, Howells, Fiona, Ward, Angela, Zalzal, Paul, Brien, Heather, Naumetz, V, Weening, Brad, Wai, Eugene K, Papp, Steve, Gofton, Wade T, Kingwell, Stephen P, Johnson, Garth, O’Neil, Joseph, Roffey, Darren M, Borsella, Vivian, Oliver, Todd M, Jones, Vicki, Endres, Terrence J, Agnew, Samuel G, Jeray, Kyle J, Broderick, J. Scott, Goetz, David R, Pace, Thomas B, Schaller, Thomas M, Porter, Scott E, Tanner, Stephanie L, Snider, Rebecca G, Nastoff, Lauren A, Bielby, Shea A, Switzer, Julie A, Cole, Peter A, Anderson, Sarah A, Lafferty, Paul M, Li, Mengnai, Ly, Thuan V, Marston, Scott B, Foley, Amy L, Vang, Sandy, Wright, David M, Marcantonio, Andrew J, Kain, Michael SH, Iorio, Richard, Specht, Lawrence M, Tilzey, John F, Lobo, Margaret J, Garfi, John S, Vallier, Heather A, Dolenc, Andrea, Robinson, Chalitha, Prayson, Michael J, Laughlin, Richard, Rubino, L. Joseph, May, Jedediah, Rieser, Geoffrey Ryan, Dulaney-Cripe, Liz, Gayton, Chris, Gorczyca, John T, Gross, Jonathan M, Humphrey, Catherine A, Kates, Stephen, Noble, Krista, McIntyre, Allison W, Pecorella, Kaili, Davis, Craig A, Lindenbaum, Stephen, Schwappach, John, Baker, Janell K, Rutherford, Tori, Newman, Heike, Lieberman, Shane, Finn, Erin, Robbins, Kristin, Hurley, Meghan, Lyle, Lindsey, Mitchell, Khalis, Browner, Kieran, Whatley, Erica, Payton, Krystal, Reeves, Christina, Cannada, Lisa K, Karges, David, Hill, Leslie, Esterhai, John, Horan, Annamarie D, Kaminski, Christine A, Kowalski, Brynn N, Keeve, Jonathan P, Anderson, Christopher G, McDonald, Michael D, Hoffman, Jodi M, Tarkin, Ivan, Siska, Peter, Gruen, Gary, Evans, Andrew, Farrell, Dana J, Irrgang, James, Luther, Arlene, Cross, William W, III, Cass, Joseph R, Sems, Stephen A, Torchia, Michael E, Scrabeck, Tyson, Jenkins, Mark, Dumais, Jules, Romero, Amanda W, Sagebien, Carlos A, Butler, Mark S, Monica, James T, Seuffert, Patricia, Hsu, Joseph R, Ficke, James, Charlton, Michael, Napierala, Matthew, Fan, Mary, Tannoury, Chadi, Archdeacon, Michael, Finnan, Ryan, Le, Toan, Wyrick, John, Hess, Shelley, Brennan, Michael L, Probe, Robert, Kile, Evelyn, Mills, Kelli, Clipper, Lydia, Yu, Michelle, Erwin, Katie, Horwitz, Daniel, Strohecker, Kent, Swenson, Teresa K, Schmidt, Andrew H, Westberg, Jerald R, Aurang, Kamran, Zohman, Gary, Peterson, Brett, Huff, Roger B, Baele, Joseph, Weber, Timothy, Edison, Matt, McBeth, Jessica, Ertl, Janos P, Parr, J. Andrew, Moore, Molly M, Tobias, Erin, Thomas, Emily, DePaolo, Charles J, Shell, Leslie E, Hampton, Lynne, Shepard, Stephanie, Nanney, Tracy, Cuento, Claudine, Cantu, Robert V, Henderson, Eric R, Eickhoff, Linda S, Hammerberg, E. Mark, Stahel, Philip, Hak, David, Mauffrey, Cyril, Gibula, Douglas, Gissel, Hannah, Henderson, Corey, Zamorano, David P, Tynan, Martin C, Lawson, Deanna, Crist, Brett D, Murtha, Yvonne M, Anderson, Linda K, Linehan, Colleen, Pilling, Lindsey, Lewis, Courtland G, Sullivan, Raymond J, Roper, Elizabeth, Obremskey, William, Kregor, Philip, Richards, Justin E, Stringfellow, Kenya, Dohm, Michael P, Zellar, Abby, Segers, Michiel JM, Zijl, Jacco AC, Verhoeven, Bart, Smits, Anke B, de Vries, Jean Paul PM, Fioole, Bram, van der Hoeven, Henk, Theunissen, Evert BM, de Vries Reilingh, Tammo S, Govaert, Lonneke, Wittich, Philippe, de Brauw, Maurits, Wille, Jan, Go, Peter M.N.Y.M., Ritchie, Ewan D, Wessel, Ronald N, Hammacher, Eric R, Visser, Gijs A, Stockmann, Heyn, Silvis, Rob, Snellen, Jaap P, Rijbroek, Bram, Scheepers, Joris JG, Vermeulen, Erik GJ, Siroen, Michiel PC, Vuylsteke, Ronald, Brom, Hans LF, Rijna, Herman, de Rijcke, Piet AR, Koppert, Cees L, Buijk, Steven E, Groenendijk, Richard PR, Dawson, Imro, Tetteroo, Geert WM, Bruijninckx, Milko MM, Doornebosch, Pascal G, de Graaf, Eelco JR, van der Elst, Maarten, van der Pol, Carmen C, van’t Riet, Martijne, Karsten, Tom M, de Vries, Mark R, Stassen, Laurents PS, Schep, Niels WL, Ben Schmidt, G, Hoffman, W H, van der Heijden, Frank H.W.M., Willems, W. Jaap, van der Hart, Cor P, Turckan, Kahn, Festen, Sebastiaan, de Nies, Frank, Out, Nico JM, Bosma, Jan, van Kampen, Albert, Biert, Jan, van Vugt, Arie B, Edwards, Michael JR, Blokhuis, Taco J, Frölke, Jan Paul M, Geeraedts, Leo MG, Gardeniers, Jean WM, Tan, Edward T.C.H., Poelhekke, Lodewijk M.S.J., de Waal Malefijt, Maarten C, Schreurs, Bart, Roukema, Gert R, Josaputra, Hong A, Keller, Paul, de Rooij, Peter D, Kuiken, Hans, Boxma, Han, Cleffken, Berry I, Liem, Ronald, Rhemrev, Steven J, Bosman, Coks HR, de Mol van Otterloo, Alexander, Hoogendoorn, Jochem, de Vries, Alexander C, Meylaerts, Sven AG, Verhofstad, Michiel HJ, Meijer, Joost, van Egmond, Teun, van der Brand, Igor, Patka, Peter, Eversdijk, Martin G, Peters, Rolf, Den Hartog, Dennis, Van Waes, Oscar JF, Oprel, Pim, Campo, Martin, Verhagen, Ronald, Albers, G.H. Robert, Simmermacher, Rogier KJ, van Mulken, Jeroen, van Wessem, Karlijn, van Gaalen, Steven M, Leenen, Luke PH, Bronkhorst, Maarten W.G.A., Guicherit, Onno R, Goslings, J. Carel, Ponsen, Kees Jan, Bhatia, Mahesh, Arora, Vinod, Tyagi, Vivek, Gupta, Ajay, Jain, Neeraj, Khan, Farah, Sharma, Ateet, Sanghavi, Amir, Trivedi, Mittal, Rai, Anil, Subash, Rai, Kamal, Yadav, Vineet, Singh, Sanjay, Prasad, Amal Shankar, Mishra, Vimlesh, Sundaresh, D C, Khanna, Angshuman, Cherian, Joe Joseph, Olakkengil, Davy J, Sharma, Gaurav, Dadi, Akhil, Palla, Naveen, Ganguly, Utsav, Rai, B. Sachidananda, Rajakumar, Janakiraman, Hull, Peter, Lewis, Sophie, Evans, Simone, Nanda, Rajesh, Logishetty, Rajanikanth, Anand, Sanjeev, Bowler, Carol, Jennings, Andrew, Chuter, Graham, Rose, Glynis, Horner, Gillian, Clark, Callum, Eke, Kate, Reed, Mike, Herriott, Chris, Dobb, Christine, Curry, Hamish, Etherington, Greg, Jain, Arvind, Moaveni, Ash, Russ, Matthias, Donald, Geoff, Weinrauch, Patrick, Pincus, Paul, Yang, Steven, Halliday, Brett, Gervais, Trevor, Holt, Michael, Flynn, Annette, Pirpiris, Marinis, Love, David, Bucknill, Andrew, Farrugia, Richard J, Ianssen, Torben, Amundsen, Asgeir, Brattgjerd, Jan Egil, Borch, Tor, Bøe, Berthe, Flatøy, Bernhard, Hasselund, Sondre, Haug, Knut Jørgen, Hemlock, Kim, Hoseth, Tor Magne, Jomaas, Geir, Kibsgård, Thomas, Lona, Tarjei, Moatshe, Gilbert, Müller, Oliver, Molund, Marius, Nicolaisen, Tor, Nilsen, Fredrik, Rydinge, Jonas, Smedsrud, Morten, Stødle, Are, Trommer, Axel, Ugland, Stein, Karlsten, Anders, Ekås, Guri, Pape, Hans-Christoph, Knobe, Matthias, and Pfeifer, Roman
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- 2015
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35. The learning curve of transanal total mesorectal excision for rectal cancer is associated with local recurrence: results from a multicentre external audit:results from a multicentre external audit
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van Oostendorp, Stefan E., Belgers, H. J., Hol, Jeroen C., Doornebosch, Pascal G., Belt, Eric J. Th., Oosterling, Steven J., Kusters, Miranda, Bonjer, H. J., Sietses, Colin, Tuynman, Jurriaan B., Boerma, E. J., Creemers, D., Graaf, E. J. De, van der Hoeven, J. A. B., Sosef, M. N., Stockmann, H. B. A. C., van der Stok, E. P., Vuylsteke, R. C. L. M., Surgery, CCA - Cancer Treatment and quality of life, APH - Global Health, APH - Quality of Care, and Amsterdam Gastroenterology Endocrinology Metabolism
- Abstract
Aim: Transanal total mesorectal excision (TaTME) has been suggested as a potential solution for the resection of challenging mid and low rectal cancer. This relatively complex procedure has been implemented in many centres over the last years, despite the absence of long-term safety data. Recently, concern has arisen because of an increase in local recurrence in the implementation phase. The aim of this study was to assess the correlation between accumulated experience and local recurrences. Method: An independent clinical researcher performed an external audit of consecutive series of all TaTME procedures in six centres in the Netherlands. Kaplan–Meier estimated local recurrence rates were calculated and multivariate Cox proportional hazards regression analysis performed to assess risk factors for local recurrence. Primary outcome was the local recurrence rate in the initial implementation (cases 1–10), continued adoption (cases 11-40) and prolonged experience (case 41 onward). Results: Six hundred and twenty-four consecutive patients underwent TaTME for rectal cancer with a median follow-up of 27 months (range 1–82 months). The estimated 2- and 3-year local recurrence rates were 4.6% and 6.6%, respectively. Cox proportional hazards regression revealed procedural experience to be an independent factor in multivariate analysis next to advanced stage (ycMRF+, pT3-4, pN+) and pelvic sepsis. Corrected analysis projected the 3-year local recurrence rates to be 9.7%, 3.3% and 3.5% for the implementation, continued adoption and prolonged experience cohorts, respectively. Conclusion: This multicentre study shows a high local recurrence rate (12.5%) after implementation of TaTME which lowers to an acceptable rate (3.4%) when experience increases. Therefore, intensified proctoring and further precautions must be implemented to reduce the unacceptably high risk of local recurrence at units starting this technique.
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- 2021
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36. Transanal endoscopic microsurgery for T1 rectal cancer: size matters!
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Doornebosch, Pascal G., Zeestraten, Eliane, de Graaf, Eelco J. R., Hermsen, Pleun, Dawson, Imro, Tollenaar, Rob A. E. M., and Morreau, Hans
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- 2012
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37. An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity
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Xu, Yuanming, primary, Carrascosa, Lucia Campos, additional, Yeung, Yik Andy, additional, Chu, Matthew Ling-Hon, additional, Yang, Wenjing, additional, Djuretic, Ivana, additional, Pappas, Danielle C., additional, Zeytounian, John, additional, Ge, Zhouhong, additional, de Ruiter, Valeska, additional, Starbeck-Miller, Gabriel R., additional, Patterson, James, additional, Rigas, Diamanda, additional, Chen, Shih-Hsun, additional, Kraynov, Eugenia, additional, Boor, Patrick P., additional, Noordam, Lisanne, additional, Doukas, Michael, additional, Tsao, Dave, additional, Ijzermans, Jan N., additional, Guo, Jie, additional, Grünhagen, Dirk J., additional, Erdmann, Joris, additional, Verheij, Joanne, additional, van Royen, Martin E., additional, Doornebosch, Pascal G., additional, Feldman, Renny, additional, Park, Terrence, additional, Mahmoudi, Salah, additional, Dorywalska, Magdalena, additional, Ni, Irene, additional, Chin, Sherman M., additional, Mistry, Tina, additional, Mosyak, Lidia, additional, Lin, Laura, additional, Ching, Keith A., additional, Lindquist, Kevin C., additional, Ji, Changhua, additional, Londono, Luz Marina, additional, Kuang, Bing, additional, Rickert, Robert, additional, Kwekkeboom, Jaap, additional, Sprengers, Dave, additional, Huang, Tzu-Hsuan, additional, and Chaparro-Riggers, Javier, additional
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- 2021
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38. Importance of patient reported and clinical outcomes for patients with locally advanced rectal cancer and their treating physicians. Do clinicians know what patients want?
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van der Valk, Maxime J.M., primary, van der Sande, Marit E., additional, Toebes, Renee E., additional, Breukink, Stephanie O., additional, Bröker, Mirelle E.E., additional, Doornebosch, Pascal G., additional, Maliko, Nansi, additional, Neijenhuis, Peter A., additional, Marinelli, Andreas W.K.S., additional, Peters, Femke P., additional, Peeters, Koen C.M.J., additional, Beets, Geerard L., additional, Marang-van de Mheen, Perla J., additional, and Hilling, Denise E., additional
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- 2020
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39. Additional file 1 of Transanal minimally invasive surgery (TAMIS) versus endoscopic submucosal dissection (ESD) for resection of non-pedunculated rectal lesions (TRIASSIC study): study protocol of a European multicenter randomised controlled trial
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Dekkers, Nik, Boonstra, Jurjen J., Moons, Leon M. G., Hompes, Roel, Bastiaansen, Barbara A., Tuynman, Jurriaan B., Koch, Arjun D., Weusten, Bas L. A. M., Pronk, Apollo, Neijenhuis, Peter A., Westerterp, Marinke, Hout, Wilbert B. Van Den, Langers, Alexandra M. J., Jolein Van Der Kraan, Alkhalaf, Alaa, Lai, Jonathan Y. L., Borg, Frank Ter, Fabry, Hans, Halet, Eric, Schwartz, Matthijs P., Nagengast, Wouter B., Straathof, Jan Willem A., Hove, Rogier W. R. Ten, Oterdoom, Leendert H., Hoff, Christiaan, Belt, Eric J Th, Zimmerman, David D. E., Hadithi, Muhammed, Morreau, Hans, Erienne M. V. De Cuba, Leijtens, Jeroen W. A., Vasen, Hans F. A., Leerdam, Monique E. Van, Graaf, Eelco J. R. De, Doornebosch, Pascal G., and Hardwick, James C. H.
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Data_FILES - Abstract
Additional file 1.
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- 2020
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40. Transanal minimally invasive surgery (TAMIS) versus endoscopic submucosal dissection (ESD) for resection of non-pedunculated rectal lesions (TRIASSIC study): Study protocol of a European multicenter randomised controlled trial
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MS MDL 1, Cancer, Dekkers, Nik, Boonstra, Jurjen J., Moons, Leon M.G., Hompes, Roel, Bastiaansen, Barbara A., Tuynman, Jurriaan B., Koch, Arjun D., Weusten, Bas L.A.M., Pronk, Apollo, Neijenhuis, Peter A., Westerterp, Marinke, Van Den Hout, Wilbert B., Langers, Alexandra M.J., Van Der Kraan, Jolein, Alkhalaf, Alaa, Lai, Jonathan Y.L., Ter Borg, Frank, Fabry, Hans, Halet, Eric, Schwartz, Matthijs P., Nagengast, Wouter B., Straathof, Jan Willem A., Ten Hove, Rogier W.R., Oterdoom, Leendert H., Hoff, Christiaan, Belt, Eric J.Th, Zimmerman, David D.E., Hadithi, Muhammed, Morreau, Hans, De Cuba, Erienne M.V., Leijtens, Jeroen W.A., Vasen, Hans F.A., Van Leerdam, Monique E., De Graaf, Eelco J.R., Doornebosch, Pascal G., Hardwick, James C.H., MS MDL 1, Cancer, Dekkers, Nik, Boonstra, Jurjen J., Moons, Leon M.G., Hompes, Roel, Bastiaansen, Barbara A., Tuynman, Jurriaan B., Koch, Arjun D., Weusten, Bas L.A.M., Pronk, Apollo, Neijenhuis, Peter A., Westerterp, Marinke, Van Den Hout, Wilbert B., Langers, Alexandra M.J., Van Der Kraan, Jolein, Alkhalaf, Alaa, Lai, Jonathan Y.L., Ter Borg, Frank, Fabry, Hans, Halet, Eric, Schwartz, Matthijs P., Nagengast, Wouter B., Straathof, Jan Willem A., Ten Hove, Rogier W.R., Oterdoom, Leendert H., Hoff, Christiaan, Belt, Eric J.Th, Zimmerman, David D.E., Hadithi, Muhammed, Morreau, Hans, De Cuba, Erienne M.V., Leijtens, Jeroen W.A., Vasen, Hans F.A., Van Leerdam, Monique E., De Graaf, Eelco J.R., Doornebosch, Pascal G., and Hardwick, James C.H.
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- 2020
41. Implementation and outcome of minor and major minimally invasive liver surgery in the Netherlands
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van der Poel, Marcel J., primary, Fichtinger, Robert S., additional, Bemelmans, Marc, additional, Bosscha, Koop, additional, Braat, Andries E., additional, de Boer, Marieke T., additional, Dejong, Cornelis H.C., additional, Doornebosch, Pascal G., additional, Draaisma, Werner A., additional, Gerhards, Michael F., additional, Gobardhan, Paul D., additional, Gorgec, Burak, additional, Hagendoorn, Jeroen, additional, Kazemier, Geert, additional, Klaase, Joost, additional, Leclercq, Wouter K.G., additional, Liem, Mike S., additional, Lips, Daan J., additional, Marsman, Hendrik A., additional, Mieog, J. Sven D., additional, Molenaar, Quintus I., additional, Nieuwenhuijs, Vincent B., additional, Nota, Carolijn L., additional, Patijn, Gijs A., additional, Rijken, Arjen M., additional, Slooter, Gerrit D., additional, Stommel, Martijn W.J., additional, Swijnenburg, Rutger-Jan, additional, Tanis, Pieter J., additional, te Riele, Wouter W., additional, Terkivatan, Türkan, additional, van den Tol, Petrousjka M., additional, van den Boezem, Peter B., additional, van der Hoeven, Joost A., additional, Vermaas, Maarten, additional, Abu Hilal, Moh'd, additional, van Dam, Ronald M., additional, Besselink, Marc G., additional, Zonderhuis, Babs, additional, Rinkes, Inne B., additional, Hoff, Christiaan, additional, and Oosterling, Steven, additional
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- 2019
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42. Survival after local excision for rectal cancer: a population-based overview of clinical practice and outcome
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Verseveld, Maria, primary, de Wilt, Johannes H.W., additional, Elferink, Marloes A.G., additional, de Graaf, Eelco J.R., additional, Verhoef, Cees, additional, Pouwels, Sjaak, additional, and Doornebosch, Pascal G., additional
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- 2019
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43. The CARTS study: Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery
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Bökkerink Guus MJ, de Graaf Eelco JR, Punt Cornelis JA, Nagtegaal Iris D, Rütten Heidi, Nuyttens Joost JME, van Meerten Esther, Doornebosch Pascal G, Tanis Pieter J, Derksen Eric J, Dwarkasing Roy S, Marijnen Corrie AM, Cats Annemieke, Tollenaar Rob AEM, de Hingh Ignace HJT, Rutten Harm JT, van der Schelling George P, ten Tije Albert J, Leijtens Jeroen WA, Lammering Guido, Beets Geerard L, Aufenacker Theo J, Pronk Apollo, Manusama Eric R, Hoff Christiaan, Bremers Andreas JA, Verhoef Cornelelis, and de Wilt Johannes HW
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Surgery ,RD1-811 - Abstract
Abstract Background The CARTS study is a multicenter feasibility study, investigating the role of rectum saving surgery for distal rectal cancer. Methods/Design Patients with a clinical T1-3 N0 M0 rectal adenocarcinoma below 10 cm from the anal verge will receive neoadjuvant chemoradiation therapy (25 fractions of 2 Gy with concurrent capecitabine). Transanal Endoscopic Microsurgery (TEM) will be performed 8 - 10 weeks after the end of the preoperative treatment depending on the clinical response. Primary objective is to determine the number of patients with a (near) complete pathological response after chemoradiation therapy and TEM. Secondary objectives are the local recurrence rate and quality of life after this combined therapeutic modality. A three-step analysis will be performed after 20, 33 and 55 patients to ensure the feasibility of this treatment protocol. Discussion The CARTS-study is one of the first prospective multicentre trials to investigate the role of a rectum saving treatment modality using chemoradiation therapy and local excision. The CARTS study is registered at clinicaltrials.gov (NCT01273051)
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- 2011
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44. Transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND-study)
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Geldof Han, Breumelhof Ronald, Mallant-Hent Rosalie CH, Jansen Jeroen M, van der Linde Klaas, Heine G Dimitri N, van Dullemen Hendrik M, Hoff Christiaan, Davids Paul HP, Bijnen A Bart, Derksen Erik J, Boom Maarten J, Schwartz Matthijs P, Consten Esther CJ, Gerhards Michael F, Weusten Bas LAM, Timmer Robin, Haringsma Jelle, Reitsma Johannes B, Dijkgraaf Marcel GW, de Graaf Eelco JR, van den Broek Frank JC, Hardwick James CH, Doornebosch Pascal G, Depla Annekatrien CTM, Ernst Miranda F, van Munster Ivo P, de Hingh Ignace HJT, Schoon Erik J, Bemelman Willem A, Fockens Paul, and Dekker Evelien
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Surgery ,RD1-811 - Abstract
Abstract Background Recent non-randomized studies suggest that extended endoscopic mucosal resection (EMR) is equally effective in removing large rectal adenomas as transanal endoscopic microsurgery (TEM). If equally effective, EMR might be a more cost-effective approach as this strategy does not require expensive equipment, general anesthesia and hospital admission. Furthermore, EMR appears to be associated with fewer complications. The aim of this study is to compare the cost-effectiveness and cost-utility of TEM and EMR for the resection of large rectal adenomas. Methods/design Multicenter randomized trial among 15 hospitals in the Netherlands. Patients with a rectal adenoma ≥ 3 cm, located between 1–15 cm ab ano, will be randomized to a TEM- or EMR-treatment strategy. For TEM, patients will be treated under general anesthesia, adenomas will be dissected en-bloc by a full-thickness excision, and patients will be admitted to the hospital. For EMR, no or conscious sedation is used, lesions will be resected through the submucosal plane in a piecemeal fashion, and patients will be discharged from the hospital. Residual adenoma that is visible during the first surveillance endoscopy at 3 months will be removed endoscopically in both treatment strategies and is considered as part of the primary treatment. Primary outcome measure is the proportion of patients with recurrence after 3 months. Secondary outcome measures are: 2) number of days not spent in hospital from initial treatment until 2 years afterwards; 3) major and minor morbidity; 4) disease specific and general quality of life; 5) anorectal function; 6) health care utilization and costs. A cost-effectiveness and cost-utility analysis of EMR against TEM for large rectal adenomas will be performed from a societal perspective with respectively the costs per recurrence free patient and the cost per quality adjusted life year as outcome measures. Based on comparable recurrence rates for TEM and EMR of 3.3% and considering an upper-limit of 10% for EMR to be non-inferior (beta-error 0.2 and one-sided alpha-error 0.05), 89 patients are needed per group. Discussion The TREND study is the first randomized trial evaluating whether TEM or EMR is more cost-effective for the treatment of large rectal adenomas. Trial registration number (trialregister.nl) NTR1422
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- 2009
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45. Transanal Endoscopic Microsurgery with or without Completion Total Mesorectal Excision for T2 and T3 Rectal Carcinoma
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Leijtens, J.W.A., Koedam, T.W., Borstlap, Wernard A.A., Maas, Monique, Doornebosch, Pascal G., Karsten, Tom M., Rosman, C., Bremers, A.J.A., Tuynman, J.B., Rademakers, Kevin L.J., Leijtens, J.W.A., Koedam, T.W., Borstlap, Wernard A.A., Maas, Monique, Doornebosch, Pascal G., Karsten, Tom M., Rosman, C., Bremers, A.J.A., Tuynman, J.B., and Rademakers, Kevin L.J.
- Abstract
Contains fulltext : 201272.pdf (publisher's version ) (Closed access)
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- 2019
46. Implementation and outcome of minor and major minimally invasive liver surgery in the Netherlands
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van der Poel, Marcel J., Fichtinger, Robert S., Bemelmans, Marc, Bosscha, Koop, Braat, Andries E., de Boer, Marieke T., Dejong, Cornelis H. C., Doornebosch, Pascal G., Draaisma, Werner A., Gerhards, Michael F., Gobardhan, Paul D., Gorgec, Burak, Hagendoorn, Jeroen, Kazemier, Geert, Klaase, Joost, Leclercq, Wouter K. G., Liem, Mike S., Lips, Daan J., Marsman, Hendrik A., Mieog, J. Sven D., Molenaar, Quintus I., Nieuwenhuijs, Vincent B., Nota, Carolijn L., Patijn, Gijs A., Rijken, Arjen M., Slooter, Gerrit D., Stommel, Martijn W. J., Swijnenburg, Rutger-Jan, Tanis, Pieter J., te Riele, Wouter W., Terkivatan, Turkan, van den Tol, Petrousjka M., van den Boezem, Peter B., van der Hoeven, Joost A., Vermaas, Maarten, Abu Hilal, Moh'd, van Dam, Ronald M., Besselink, Marc G., Zonderhuis, Babs, Rinkes, Inne B., Hoff, Christiaan, Oosterling, Steven, van der Poel, Marcel J., Fichtinger, Robert S., Bemelmans, Marc, Bosscha, Koop, Braat, Andries E., de Boer, Marieke T., Dejong, Cornelis H. C., Doornebosch, Pascal G., Draaisma, Werner A., Gerhards, Michael F., Gobardhan, Paul D., Gorgec, Burak, Hagendoorn, Jeroen, Kazemier, Geert, Klaase, Joost, Leclercq, Wouter K. G., Liem, Mike S., Lips, Daan J., Marsman, Hendrik A., Mieog, J. Sven D., Molenaar, Quintus I., Nieuwenhuijs, Vincent B., Nota, Carolijn L., Patijn, Gijs A., Rijken, Arjen M., Slooter, Gerrit D., Stommel, Martijn W. J., Swijnenburg, Rutger-Jan, Tanis, Pieter J., te Riele, Wouter W., Terkivatan, Turkan, van den Tol, Petrousjka M., van den Boezem, Peter B., van der Hoeven, Joost A., Vermaas, Maarten, Abu Hilal, Moh'd, van Dam, Ronald M., Besselink, Marc G., Zonderhuis, Babs, Rinkes, Inne B., Hoff, Christiaan, and Oosterling, Steven
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- 2019
47. Implementation and outcome of minor and major minimally invasive liver surgery in the Netherlands
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MS CGO, Cancer, van der Poel, Marcel J., Fichtinger, Robert S., Bemelmans, Marc, Bosscha, Koop, Braat, Andries E., de Boer, Marieke T., Dejong, Cornelis H. C., Doornebosch, Pascal G., Draaisma, Werner A., Gerhards, Michael F., Gobardhan, Paul D., Gorgec, Burak, Hagendoorn, Jeroen, Kazemier, Geert, Klaase, Joost, Leclercq, Wouter K. G., Liem, Mike S., Lips, Daan J., Marsman, Hendrik A., Mieog, J. Sven D., Molenaar, Quintus I., Nieuwenhuijs, Vincent B., Nota, Carolijn L., Patijn, Gijs A., Rijken, Arjen M., Slooter, Gerrit D., Stommel, Martijn W. J., Swijnenburg, Rutger-Jan, Tanis, Pieter J., te Riele, Wouter W., Terkivatan, Turkan, van den Tol, Petrousjka M., van den Boezem, Peter B., van der Hoeven, Joost A., Vermaas, Maarten, Abu Hilal, Moh'd, van Dam, Ronald M., Besselink, Marc G., Zonderhuis, Babs, Rinkes, Inne B., Hoff, Christiaan, Oosterling, Steven, MS CGO, Cancer, van der Poel, Marcel J., Fichtinger, Robert S., Bemelmans, Marc, Bosscha, Koop, Braat, Andries E., de Boer, Marieke T., Dejong, Cornelis H. C., Doornebosch, Pascal G., Draaisma, Werner A., Gerhards, Michael F., Gobardhan, Paul D., Gorgec, Burak, Hagendoorn, Jeroen, Kazemier, Geert, Klaase, Joost, Leclercq, Wouter K. G., Liem, Mike S., Lips, Daan J., Marsman, Hendrik A., Mieog, J. Sven D., Molenaar, Quintus I., Nieuwenhuijs, Vincent B., Nota, Carolijn L., Patijn, Gijs A., Rijken, Arjen M., Slooter, Gerrit D., Stommel, Martijn W. J., Swijnenburg, Rutger-Jan, Tanis, Pieter J., te Riele, Wouter W., Terkivatan, Turkan, van den Tol, Petrousjka M., van den Boezem, Peter B., van der Hoeven, Joost A., Vermaas, Maarten, Abu Hilal, Moh'd, van Dam, Ronald M., Besselink, Marc G., Zonderhuis, Babs, Rinkes, Inne B., Hoff, Christiaan, and Oosterling, Steven
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- 2019
48. Transanal Endoscopic Microsurgery with or without Completion Total Mesorectal Excision for T2 and T3 Rectal Carcinoma
- Author
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Leijtens, Jeroen W.A., primary, Koedam, Thomas W.A., additional, Borstlap, Wernard A.A., additional, Maas, Monique, additional, Doornebosch, Pascal G., additional, Karsten, Tom M., additional, Derksen, Eric J., additional, Stassen, Laurents P.S., additional, Rosman, Camiel, additional, de Graaf, Eelco J.R., additional, Bremers, André J.A., additional, Heemskerk, Jeroen, additional, Beets, Geerard L., additional, Tuynman, Jurriaan B., additional, and Rademakers, Kevin L.J., additional
- Published
- 2018
- Full Text
- View/download PDF
49. The occurrence and characteristics of endoscopically unexpected malignant degeneration in large rectal adenomas
- Author
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Bronzwaer, Maxime E.S., primary, Musters, Gijsbert D., additional, Barendse, Renée M., additional, Koens, Lianne, additional, de Graaf, Eelco J.R., additional, Doornebosch, Pascal G., additional, Schwartz, Matthijs P., additional, Consten, Esther C.J., additional, Schoon, Erik J., additional, de Hingh, Ignace H.J.T., additional, Tanis, Pieter J., additional, Dekker, Evelien, additional, Fockens, Paul, additional, Bemelman, Willem A., additional, Bijnen, Bart, additional, Bisschops, Raf, additional, van den Broek, Frank J.C., additional, Davids, Paul, additional, Depla, Annekatrien, additional, van Dullemen, Hendrik, additional, Hardwick, James C., additional, Hoff, Chrisiaan, additional, Houben, Martin, additional, Jansen, Jeroen M., additional, Gerhards, Michael F., additional, van der Linde, Klaas, additional, van Milligen de Wit, A.W. Marc, additional, Mallant, Rosalie, additional, van der Schelling, George P., additional, Timmer, Robin, additional, Witteman, Ben, additional, Weusten, Bas L.A.M., additional, and Wolthuis, Albert, additional
- Published
- 2018
- Full Text
- View/download PDF
50. Incisional Negative-Pressure Wound Therapy for Perineal Wounds After Abdominoperineal Resection for Rectal Cancer, a Pilot Study
- Author
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van der Valk, Maxime J.M., primary, de Graaf, Eelco J.R., additional, Doornebosch, Pascal G., additional, and Vermaas, Maarten, additional
- Published
- 2017
- Full Text
- View/download PDF
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