1,431 results on '"Donnelly, C"'
Search Results
2. High-resolution three-dimensional imaging of topological textures in nanoscale single-diamond networks
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Karpov, D., Djeghdi, K., Holler, M., Abdollahi, S. Narjes, Godlewska, K., Donnelly, C., Yuasa, T., Sai, H., Wiesner, U. B., Wilts, B. D., Steiner, U., Musya, M., Fukami, S., Ohno, H., Gunkel, I., Diaz, A., and Llandro, J.
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- 2024
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3. 2024 Roadmap on Magnetic Microscopy Techniques and Their Applications in Materials Science
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Christensen, D. V., Staub, U., Devidas, T. R., Kalisky, B., Nowack, K. C., Webb, J. L., Andersen, U. L., Huck, A., Broadway, D. A., Wagner, K., Maletinsky, P., van der Sar, T., Du, C. R., Yacoby, A., Collomb, D., Bending, S., Oral, A., Hug, H. J., Mandru, A. -O., Neu, V., Schumacher, H. W., Sievers, S., Saito, H., Khajetoorians, A. A., Hauptmann, N., Baumann, S., Eichler, A., Degen, C. L., McCord, J., Vogel, M., Fiebig, M., Fischer, P., Hierro-Rodriguez, A., Finizio, S., Dhesi, S. S., Donnelly, C., Büttner, Felix, Kfir, O., Hu, W., Zayko, S., Eisebitt, S., Pfau, B., Frömter, R., Kläui, M., Yasin, F. S., McMorran, B. J., Seki, S., Yu, X., Lubk, A., Wolf, D., Pryds, N., Makarov, D., and Poggio, M.
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Superconductivity ,Quantum Physics - Abstract
Considering the growing interest in magnetic materials for unconventional computing, data storage, and sensor applications, there is active research not only on material synthesis but also characterisation of their properties. In addition to structural and integral magnetic characterisations, imaging of magnetization patterns, current distributions and magnetic fields at nano- and microscale is of major importance to understand the material responses and qualify them for specific applications. In this roadmap, we aim to cover a broad portfolio of techniques to perform nano- and microscale magnetic imaging using SQUIDs, spin center and Hall effect magnetometries, scanning probe microscopies, x-ray- and electron-based methods as well as magnetooptics and nanoMRI. The roadmap is aimed as a single access point of information for experts in the field as well as the young generation of students outlining prospects of the development of magnetic imaging technologies for the upcoming decade with a focus on physics, materials science, and chemistry of planar, 3D and geometrically curved objects of different material classes including 2D materials, complex oxides, semi-metals, multiferroics, skyrmions, antiferromagnets, frustrated magnets, magnetic molecules/nanoparticles, ionic conductors, superconductors, spintronic and spinorbitronic materials.
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- 2024
4. Determination of optimal experimental conditions for accurate 3D reconstruction of the magnetization vector via XMCD-PEEM
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Sandoval, Miguel A. Cascales, Hierro-Rodríguez, A., Ruiz-Gómez, S., Skoric, L., Donnelly, C., Niño, M. A., McGrouther, D., McVitie, S., Flewett, S., Jaouen, N., Belkhou, R., Foerster, M., and Fernández-Pacheco, A.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
In this work we present a detailed analysis on the performance of X-ray magnetic circular dichroism photo-emission electron microscopy (XMCD-PEEM) as a tool for vector reconstruction of the magnetization. For this, we choose 360$^{\circ}$ domain wall ring structures which form in a synthetic antiferromagnet as our model to conduct the quantitative analysis. We assess how the quality of the results is affected depending on the number of projections that are involved in the reconstruction process, as well as their angular distribution. For this we develop a self-consistent error metric, which indicates that the main factor of improvement comes from selecting the projections evenly spread out in space, over having a larger number of these spanning a smaller angular range. This work thus poses XMCD-PEEM as a powerful tool for vector imaging of complex 3D magnetic structures.
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- 2023
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5. Observation and formation mechanism of 360{\deg} domain wall rings in Synthetic Anti-Ferromagnets with interlayer chiral interactions
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Sandoval, Miguel A. Cascales, Hierro-Rodríguez, A, Ruiz-Gómez, S., Skoric, L., Donnelly, C., Niño, M. A., Vedmedenko, Elena Y., McGrouther, D., McVitie, S., Flewett, S., Jaouen, N., Foerster, M., and Fernández-Pacheco, A.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The Interlayer Dzyaloshinskii-Moriya interaction (IL-DMI) chirally couples spins in different ferromagnetic layers of multilayer heterostructures. So far, samples with IL-DMI have been investigated utilizing magnetometry and magnetotransport techniques, where the interaction manifests as a tunable chiral exchange bias field. Here, we investigate the nanoscale configuration of the magnetization vector in a synthetic anti-ferromagnet (SAF) with IL-DMI, after applying demagnetizing field sequences. We add different global magnetic field offsets to the demagnetizing sequence in order to investigate the states that form when the IL-DMI exchange bias field is fully or partially compensated. For magnetic imaging and vector reconstruction of the remanent magnetic states we utilize X-ray magnetic circular dichroism photoemission electron microscopy, evidencing the formation of 360$^{\circ}$ domain wall rings of typically 0.5-3.0 $\mu m$ in diameter. These spin textures are only observed when the exchange bias field due to the IL-DMI is not perfectly compensated by the magnetic field offset. From a combination of micromagnetic simulations, magnetic charge distribution and topology arguments, we conclude that a non-zero remanent effective field with components both parallel and perpendicular to the anisotropy axis of the SAF is necessary to observe the rings. This work shows how the exchange bias field due to IL-DMI can lead to complex metastable spin states during reversal, important for the development of novel spintronic devices.
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- 2023
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6. Fourier-space generalized magneto-optical ellipsometry
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Sandoval, Miguel A. Cascales, Hierro-Rodríguez, A., Sanz-Hernández, D., Skoric, L., Christensen, C. N., Donnelly, C., and Fernández-Pacheco, A.
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Physics - Applied Physics ,Physics - Optics - Abstract
The magneto-optical Kerr effect (MOKE) is a widely used lab-based technique for the study of thin films and nanostructures, providing magnetic characterization with good spatial and temporal resolutions. Due to the complex coupling of light with a magnetic sample, conventional MOKE magnetometers normally work by selecting a small range of incident wave-vector values, focusing the incident light beam to a small spot, and recording the reflected intensity at that angular range by means of photodetectors. This generally provides signals proportional to a mixture of magnetization components, requiring additional methodologies for full vectorial magnetic characterization. Here, we computationally investigate a Fourier-space MOKE setup, where a focused beam ellipsometer using high numerical aperture optics and a camera detector is employed to simultaneously map the intensity distribution for a wide range of incident and reflected wave-vectors. We employ circularly incident polarized light and no analyzing optics, in combination with a fitting procedure of the light intensity maps to the analytical expression of the Kerr effect under linear approximation. In this way, we are able to retrieve the three unknown components of the magnetization vector as well as the material's optical and magneto-optical constants with high accuracy and short acquisition times, with the possibility of single shot measurements. Fourier MOKE is thus proposed as a powerful method to perform generalized magneto-optical ellipsometry for a wide range of magnetic materials and devices.
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- 2022
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7. Controlled Evolution of Three-Dimensional Magnetic States in Strongly Coupled Cylindrical Nanowire Pairs
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Fullerton, J, Hierro-Rodriguez, A, Donnelly, C, Sanz-Hernández, D, Skoric, L, MacLaren, D A, and Fernández-Pacheco, A
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Cylindrical magnetic nanowires are promising systems for the development of three-dimensional spintronic devices. Here, we simulate the evolution of magnetic states during fabrication of strongly-coupled cylindrical nanowires with varying degrees of overlap. By varying the separation between wires, the relative strength of exchange and magnetostatic coupling can be tuned. Hence leading to the formation of six fundamental states as a function of both inter-wire separation and wire height. In particular, two complex three-dimensional magnetic states, a 3D Landau Pattern and a Helical Domain wall, are observed to emerge for intermediate overlap. The competition of magnetic interactions and the parallel growth scheme we follow (growing both wires at the same time) favours the formation of these anti-parallel metastable states. This works shows how the engineering of strongly coupled 3D nanostructures with competing interactions can be used to create complex spin textures.
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- 2022
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8. Domain wall automotion in three-dimensional magnetic helical interconnectors
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Skoric, L., Donnelly, C., Hierro-Rodriguez, A., Ruiz-Gómez, S., Foerster, M., Orti, M. A. Niño, Belkhou, R., Abert, C., Suess, D., and Fernández-Pacheco, A.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Computational Physics - Abstract
The fundamental limits currently faced by traditional computing devices necessitate the exploration of new ways to store, compute and transmit information. Here, we propose a three-dimensional (3D) magnetic interconnector that exploits geometry-driven automotion of domain walls (DWs), for the transfer of magnetic information between functional magnetic planes. By combining state-of-the-art 3D nanoprinting and standard physical vapor deposition, we prototype 3D helical DW conduits. We observe the automotion of DWs by imaging their magnetic state under different field sequences using X-ray microscopy, observing a robust unidirectional motion of DWs from the bottom to the top of the spirals. From experiments and micromagnetic simulations, we determine that the large thickness gradients present in the structure are the main mechanism for 3D DW automotion. We obtain direct evidence of how this tailorable magnetic energy gradient is imprinted in the devices, and how it competes with pinning effects due to local changes in the energy landscape. Our work also predicts how this effect could lead to high DW velocities, reaching the Walker limit during automotion. This work provides new possibilities for efficient transfer of magnetic information in three dimensions.
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- 2021
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9. Micromagnetic modelling of magnetic domain walls in curved cylindrical nanotubes and nanowires
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Skoric, L., Donnelly, C., Abert, C., Hierro-Rodriguez, A., Suess, D., and Fernández-Pacheco, A.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Computational Physics - Abstract
We investigate the effect of curvature on the energy and stability of domain wall configurations in curved cylindrical nanotubes and nanowires. We use micromagnetic simulations to calculate the phase diagram for the transverse wall (TW) and vortex wall (VW) states in tubes, finding the ground state configuration and the metastability region where both types of walls can exist. The introduction of curvature shifts the range for which the TW is the ground state domain wall to higher diameters, and increases the range of metastability. We interpret this behavior to be primarily due to the curvature-induced effective Dzyaloshinskii-Moriya term in the exchange energy. Furthermore, we demonstrate qualitatively the same behavior in solid cylindrical nanowires. Comparing both tubes and wires, we observe how while in tubes curvature tends to suppress the transformation from the TW to VW, in wires it promotes the transformation of the VW containing the Bloch point into the TW. These findings have important implications in the fundamental understanding of domain walls in 3D geometries, and the design of future domain wall devices.
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- 2021
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10. Social Network Factors Affect Nutrition Risk in Middle-Aged and Older Adults: Results from the Canadian Longitudinal Study on Aging
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Mills, Christine Maire, Keller, H. H., DePaul, V. G., and Donnelly, C.
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- 2023
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11. Layer-by-layer growth of complex-shaped three-dimensional nanostructures with focused electron beams
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Skoric, L., Sanz-Hernández, D., Meng, F., Donnelly, C., Merino-Aceituno, S., and Fernández-Pacheco, A.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Applied Physics - Abstract
The fabrication of three-dimensional (3D) nanostructures is of great interest to many areas of nanotechnology currently challenged by fundamental limitations of conventional lithography. One of the most promising direct-write methods for 3D nanofabrication is focused electron beam-induced deposition (FEBID), owing to its high spatial resolution and versatility. Here we extend FEBID to the growth of complex-shaped 3D nanostructures by combining the layer-by-layer approach of conventional macroscopic 3D printers and the proximity effect correction of electron beam lithography. This framework is based on the continuum FEBID model and is capable of adjusting for a wide range of effects present during deposition, including beam-induced heating, defocussing and gas flux anisotropies. We demonstrate the capabilities of our platform by fabricating free-standing nanowires, surfaces with varying curvatures and topologies, and general 3D objects, directly from standard stereolithography (STL) files and using different precursors. Real 3D nanoprinting as demonstrated here opens up exciting avenues for the study and exploitation of 3D nanoscale phenomena., Comment: 15 pages, 4 figures
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- 2019
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12. Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 Å resolution
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Tsimbalyuk, S., Donnelly, C. M., and Forwood, J. K.
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- 2022
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13. The feasibility of home monitoring of young people with cystic fibrosis: Results from CLIMB-CF
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Edmondson, C., Westrupp, N., Seddon, P., Olden, C., Wallis, C., Dawson, C., Brodlie, M., Baxter, F., McCormick, J., MacFarlane, S., Rice, D., Macleod, A., Brooker, R., Connon, M., Ghayyda, S., Blaikie, L., Thursfield, R., Brown, L., Price, A., Fleischer, E., Itterman, J., Hughes, D., Barrett, P., Surette, M., Donnelly, C., Mateos-Corral, D., Padley, G., Wallenburg, J., Brownlee, K., Alton, E.W.F.W., Bush, A., and Davies, J.C.
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- 2022
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14. Morphologic Change by Overwash: Establishing and Evaluating Predictors
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Donnelly, C., primary
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- 2024
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15. A Discussion on the Evolution and Application of Quantitative Risk Informed Dam Safety Decision Making
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Donnelly, C. Richard, Acharya, A. M., Biswas, Asit K., Series Editor, Tortajada, Cecilia, Series Editor, Altinbilek, Dogan, Editorial Board Member, González-Gómez, Francisco, Editorial Board Member, Gopalakrishnan, Chennat, Editorial Board Member, Horne, James, Editorial Board Member, Molden, David J., Editorial Board Member, Varis, Olli, Editorial Board Member, Wang, Hao, Editorial Board Member, Mohd Sidek, Lariyah, editor, Salih, Gasim Hayder Ahmed, editor, and Boosroh, Mohd Hariffin, editor
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- 2020
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16. Seasonal ensemble forecasts for soil moisture, evapotranspiration and runoff across Australia
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Vogel, E., Lerat, J., Pipunic, R., Frost, A.J., Donnelly, C., Griffiths, M., Hudson, D., and Loh, S.
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- 2021
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17. Stochastic single flux quantum neuromorphic computing using magnetically tunable Josephson junctions
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Russek, S. E., Donnelly, C. A., Schneider, M. L., Baek, B., Pufall, M. R., Rippard, W. H., Hopkins, P. F., Dresselhaus, P. D., and Benz, S. P.
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Condensed Matter - Superconductivity ,Computer Science - Neural and Evolutionary Computing - Abstract
Single flux quantum (SFQ) circuits form a natural neuromorphic technology with SFQ pulses and superconducting transmission lines simulating action potentials and axons, respectively. Here we present a new component, magnetic Josephson junctions, that have a tunablility and re-configurability that was lacking from previous SFQ neuromorphic circuits. The nanoscale magnetic structure acts as a tunable synaptic constituent that modifies the junction critical current. These circuits can operate near the thermal limit where stochastic firing of the neurons is an essential component of the technology. This technology has the ability to create complex neural systems with greater than 10^21 neural firings per second with approximately 1 W dissipation., Comment: 2016 IEEE International Conference on Rebooting Computing (ICRC)
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- 2016
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18. Response to 'Verifying quantum superpositions at metre scales'
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Kovachy, T., Asenbaum, P., Overstreet, C., Donnelly, C. A., Dickerson, S. M., Sugarbaker, A., Hogan, J. M., and Kasevich, M. A.
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Quantum Physics ,Physics - Atomic Physics - Abstract
The preceding BCA (Stamper-Kurn et. al., arXiv:1607.01454) asserts that our observation of interference contrast in a half-metre-scale atom interferometer (Kovachy et. al., Nature 528, 530-3 (2015)) does not prove the existence of macroscopic quantum superpositions and hence does not test quantum mechanics at long length scales. Moreover, the BCA implies that intrinsic atomic interactions or technical imperfections could prevent the application of our work to future differential measurements. On the contrary, we argue the following: i) in standard quantum mechanics, there is no known mechanism in our system that prohibits its use in future differential measurement applications; ii) our experiment tests quantum mechanics in that it constrains any modifications that would reduce contrast in an interferometer with arms that propagate over widely separated trajectories; and iii) using a standard definition of superposition, our observation of interference results from quantum superposition at the half-metre scale. In particular, quantum superposition is a more general concept than first-order coherence., Comment: Response to comment by Stamper-Kurn et. al., arXiv:1607.01454
- Published
- 2016
19. Red banner--the Soviet military system in peace and war
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Donnelly, C.
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BOOK REVIEWS - Published
- 1989
20. Fatigue damage caused by superload vehicles in concrete pavements.
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Donnelly, C. A., Buettner, N. R., and Vandenbossche, J. M.
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FATIGUE cracks ,VEHICLES ,CONCRETE pavements ,ASPHALT pavements ,TENSILE strength - Abstract
Superload vehicles (SLs) are typically defined as vehicles having a gross vehicle weight (GVW) greater than 890 kN. SLs often consist of unique axle configurations that may cause significant damage to pavements. Research has been mainly limited to SLs on asphalt pavements, therefore the effect of SLs on concrete pavements is not well established. In this study, fatigue stresses in concrete pavements were quantified for a database of pavement structures and SLs to identify critical conditions that contribute to fatigue damage. A series of load pulses were constructed from a database of finite element results to identify conditions and locations within the slab for peak stress development. Tensile stress greatest in thin pavements with a stiff base layer and large positive temperature gradients subjected to tandem axle SLs. Fatigue damage was calculated for the critical cases using several damage models, and significant variation was found between models based on inputs used. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Determination of optimal experimental conditions for accurate 3D reconstruction of the magnetization vector via XMCD-PEEM
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Cascales-Sandoval, Miguel A., primary, Hierro-Rodriguez, A., additional, Ruiz-Gómez, S., additional, Skoric, L., additional, Donnelly, C., additional, Niño, M. A., additional, McGrouther, D., additional, McVitie, S., additional, Flewett, S., additional, Jaouen, N., additional, Belkhou, R., additional, Foerster, M., additional, and Fernandez-Pacheco, A., additional
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- 2024
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22. 24-Hour Ambulatory Electrocardiograms: What to Expect in a Mixed Breed Equine Population
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Maas, L. T., additional, Finno, C. J., additional, Donnelly, C. G., additional, Stern, J. A., additional, Hill, A. E., additional, and Morgan, J. M., additional
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- 2024
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23. Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort
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Shah, N, Xue, B, Xu, Z, Yang, H, Marwali, E, Dalton, H, Payne, P, Lu, C, Said, A, Abdukahil, S, Abdulkadir, N, Absil, L, Acker, A, Adriao, D, Hssain, A, Akwani, C, Qasim, E, Alalqam, R, Al-Dabbous, T, Alex, B, Al-Fares, A, Alfoudri, H, Aliudin, J, Alves, J, Alves, R, Cabrita, J, Amaral, M, Amira, N, Andini, R, Anthonidass, S, Antonelli, M, Arabi, Y, Arcadipane, A, Arenz, L, Arnold-Day, C, Arora, L, Arora, R, Ashraf, M, Asyraf, A, Atique, A, Bach, B, Baillie, J, Bak, E, Bakar, N, Balakrishnan, M, Barbalho, R, Barclay, W, Barnett, S, Barnikel, M, Barrasa, H, Barrigoto, C, Baruch, J, Hassin Basri, M, Battaglini, D, Bautista Rincon, D, Bee, K, Begum, H, Beljantsev, A, Benjiman, L, Bento, L, Bernal Sobrino, J, Bertolino, L, Bhatt, A, Bianco, C, Bidin, F, Humaid, F, Bin Kamarudin, M, Blanco-Schweizer, P, Bloos, F, Boccia, F, Bogaert, D, Borges, D, Bouhmani, D, Bouziotis, J, Boylan, M, Bozza, F, Brazzi, L, Brewster, D, Brickell, K, Broadley, T, Brozzi, N, Buchtele, N, Burrell, A, Cabral, S, Garces, R, Calligy, K, Campbell, P, Cardoso, S, Cardoso, F, Carelli, S, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castanheira, N, Castro, I, Catarino, A, Cavalin, R, Cavalli, G, Cavayas, A, Chand, M, Chen, A, Chen, Y, Cheng, M, Chica, J, Chidambaram, S, Tho, L, Cho, S, Chow, T, Chua, H, Chua, J, Cidade, J, Citarella, B, Ciullo, A, Clarke, J, Clohisey, S, Codan, C, Coles, J, Colombo, S, Connor, M, Cooke, G, Corley, A, Cornelis, S, Corpuz, A, Crump, J, Cruz, C, Cruz Bermudez, J, Rojo, J, Csete, M, Cullen, A, Cummings, M, Curley, G, Custodio, P, Filipe, A, Dabaliz, A, Dagens, A, Dahly, D, Dalton, J, Damas, J, Dankwa, E, Dantas, J, de Loughry, G, de Rosa, R, de Silva, T, Deacon, J, Dean, D, Debenedictis, B, Dell'Amore, A, Denis, E, Depuydt, P, Desai, M, Dhangar, P, Diaz, R, Dieperink, W, Docherty, A, Doherty, H, Donnelly, C, Donohue, C, Downer, T, Drake, T, Duculan, T, Dunning, J, Duplaix, M, Durante-Mangoni, E, Durham, L, Ean, S, Echeverria-Villalobos, M, Elotmani, L, Elshazly, T, Eng, C, Escher, M, Santo, C, Estevao, J, Everding, A, Fairfield, C, Faria, P, Fateena, H, Fayed, M, Fernandes, J, Fernandes, M, Fernandes, S, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fiorda, J, Fletcher, T, Florio, L, Fonseca, T, Forsyth, S, Foti, G, Fowler, R, Fraser, J, Fraser, C, Ribeiro, A, French, C, Fukuda, M, G, A, Gagliardi, M, Gaiao, S, Gamble, C, Gani, Y, Garcia, R, Barrio, N, Gavin, A, Germano, N, Giani, M, Gilroy, E, Girvan, M, Gnall, E, Goffard, J, Goh, J, Golob, J, Gonzalez, A, Graf, J, Grasselli, G, Green, C, Greenhalf, W, Grieco, D, Griffee, M, Griffiths, F, Lordemann, A, Gruner, H, Gu, Y, Guerreiro, D, Castro, M, Hakak, S, Hall, M, Halpin, S, Hamer, A, Hammond, T, Hammond, N, Han, L, Hao, K, Hardwick, H, Ekow Harrison, S, Harrison, E, Harrison, J, Heerman, J, Hendry, R, Hennessy, M, Higgins, D, Higgins, R, Hinton, S, Ho, Y, Ho, A, Hoh, W, Holt, R, Horby, P, Hsu, J, Hurd, A, Ijaz, S, Inacio, H, Ing, Y, Isgett, S, Isidoro, T, Ismail, N, Ivulich, D, Jackson, C, Jelani, A, Joe, O, Joshi, S, Jung, A, Kaisbain, N, Kaleesvran, T, Ayadi Kamaluddin, M, Che Kamaruddin, Z, Kamarudin, N, Kang, K, Karpayah, P, Kartsonaki, C, Kay, C, Keating, S, Kelly, A, Kelly, S, Kennon, K, Khalid, I, Khan, I, Kho, M, Khoo, R, Khoo, D, Khoo, S, Kiat, K, Kida, Y, Kim, J, Kitamura, N, Klenerman, P, Knight, S, Kobbe, R, Krishnan, V, Kumar, D, Kumar, G, Kurtzman, E, Lalueza, A, Lanza, M, Law, A, Lee, T, Lee, H, Lee, B, Lee, Y, Lee, J, Leeming, G, Lene, H, Leone, M, Bassi, G, Lim, K, Lim, W, Lina, L, Liu, K, Loforte, A, Loon, L, Lopes, D, Low, L, Loy, J, Bermejo, C, Lunn, M, Lyons, R, Maasikas, O, Machado, S, de la Calle, G, Maier, L, Malfertheiner, M, Malik, N, Sant'ana Malaque, C, Marino, D, Marques, A, Marsh, B, Marsh, L, Marshall, J, Martin, E, Martinez, F, Martin-Loeches, I, Martins, J, Martins, A, Rego, C, Martucci, G, Marzukie, M, Maynar, J, Mcarthur, C, Mccanny, P, Mccloskey, C, Mcdermott, S, Mcdonald, S, Mcelroy, A, Mcelwee, S, Mcevoy, N, Mckay, C, Mckeown, J, Mclean, K, Mele, F, Menkiti, O, Mentzer, A, Mergler, B, Merson, L, Mesquita, A, Meynert, A, Mihnovit, V, Miller, J, Misnan, N, Mohamed, T, Eliza Mohamed, N, Moin, A, Mone, M, Monteiro, A, Montes, C, Montrucchio, G, Moore, S, Motos, A, Muh, N, Muhamad, D, Murphy, A, Murthy, S, Muyandy, G, Nagpal, D, Nagrebetsky, A, Neto, R, Neumann, E, Ng, W, Choileain, O, Nichol, A, Nitayavardhana, P, Nonas, S, Mohd Noordin, N, Izzati Norharizam, N, Norman, L, Noursadeghi, M, Occhipinti, G, O'Donnell, M, Ogura, T, Oliveira, J, Olliaro, P, Ong, J, Oosthuyzen, W, Openshaw, P, Ortoleva, J, Osatnik, J, Othman, S, Palmarini, M, Panarello, G, Panda, P, Pang, L, Panigada, M, Parke, R, Patauner, F, Pathmanathan, M, Patterson, L, Paulos, J, Paxton, W, Peake, S, Peariasamy, K, Jimenez, M, Pelosi, P, Pereira, R, Periel, L, Pesenti, A, Pimentel, C, Pires, C, Pius, R, Png, H, Poli, S, Pollakis, G, Post, A, Postma, D, Povoa, P, Povoas, D, Preiser, J, Pritchard, M, Proenca, L, Semedi, B, Quesada, L, Quinones-Cardona, V, Gonzalez, V, Quraishi, M, Rafael, A, Rahman, R, Rahman, A, Rajahram, G, Ramalho, J, Ramli, A, Ramos, G, Rangappa, R, Ratsep, I, Rau, C, Ravi, T, Reis, R, Rello, J, Ren, H, Richardson, D, Ahmad Ridzuan, S, Rios, A, Robba, C, Roberto, A, Roberts, S, Robertson, D, Rodeia, S, Roessler, B, Roger, C, Rojek, A, Roncon-Albuquerque, R, Rose, M, Rosenberger, D, Rossetti, M, Russell, C, Ryckaert, S, Saba, I, Sadat, M, Sakiyalak, P, Salazar, L, Sales, G, Sanchez, E, Sancho-Shimizu, V, Sandhu, G, Santos, M, Satyapriya, S, Saviciute, E, Saw, Y, Schaffer, J, Schermer, T, Schwameis, M, Scott, J, Scott-Brown, J, Selvarajoo, M, Semple, M, Senian, R, Sequeira, F, Sequeira, T, Neto, A, Balazote, P, Shahidan, S, Shamsah, M, Sharma, P, Shaw, C, Shaw, V, Shetty, R, Shi, H, Shimizu, H, Shimizu, K, Shrapnel, S, Shum, H, Siang, N, Sigfrid, L, Sillaots, P, Silva, C, Heng, B, Singh, P, Singh, M, Sivam, K, Smith, S, Smood, B, Smyth, C, Snacken, M, Soh, T, Solomon, J, Solomon, T, Somers, E, Song, M, Sousa, M, Uva, M, Sperry, A, Sriskandan, S, Staudinger, T, Stecher, S, Stienstra, Y, Stolz, E, Stuart, A, Stuart, D, Suen, J, Summers, C, Suppiah, D, Syahrin, S, Sztajnbok, J, Szuldrzynski, K, Tabrizi, S, Taccone, F, Taib, S, Taleb, S, Talsma, J, Tan, K, Tan, Y, Tedder, R, Tee, T, Teixeira, J, Tejada, S, Teoh, S, Terpstra, P, Tessier-Grenier, H, Thabit, A, Tham, Z, Thangavelu, S, Thirumanickam, J, Thompson, S, Thomson, D, Thomson, E, Thorpe, M, Thurai, S, Thwaites, R, Toh, J, Tonnii, S, Torre, M, Torres, A, Towers, M, Trapani, T, Turtle, L, Udy, A, Ullrich, R, Uribe, A, Usman, A, Uyeki, T, Val-Flores, L, Van de Velde, S, Van Der Vekens, N, Van der Voort, P, Vanoverschelde, H, Vasudayan, S, Veeran, S, Ventura, S, Vidal, J, Vieira, C, Villanueva, J, Vitiello, C, Wahab, N, Wahab, S, Wahid, N, Wang, C, Webb, S, Wei, J, Wen, T, Wham, M, White, N, Wille, K, Williams, B, Williams, V, Williams, P, Wong, C, Wong, X, Wong, Y, Wong, T, Xian, G, Xian, L, Xuan, K, Mohd Yakop, S, Yamazaki, M, Yarad, E, Hing, N, Yeoh, C, Yerkovich, S, Yokoyama, T, Zaaqoq, A, Zahid, M, Binti Zaidan, N, Zambon, M, Zanella, A, Zaynah, N, Shah N., Xue B., Xu Z., Yang H., Marwali E., Dalton H., Payne P. P. R., Lu C., Said A. S., Abdukahil S. A., Abdulkadir N. N., Absil L., Acker A., Adriao D., Hssain A. A., Akwani C., Qasim E. A., Alalqam R., Al-Dabbous T., Alex B., Al-Fares A., Alfoudri H., Aliudin J., Alves J., Alves R., Alves J. M., Cabrita J. A., Amaral M., Amira N., Andini R., Anthonidass S., Antonelli M., Arabi Y., Arcadipane A., Arenz L., Arnold-Day C., Arora L., Arora R., Ashraf M., Asyraf A., Atique A., Bach B., Baillie J. K., Bak E., Bakar N. A., Balakrishnan M., Barbalho R., Barclay W. S., Barnett S. U., Barnikel M., Barrasa H., Barrigoto C., Baruch J., Hassin Basri M. F., Battaglini D., Bautista Rincon D. F., Bee K. H., Begum H., Beljantsev A., Benjiman L. E., Bento L., Bernal Sobrino J. L., Bertolino L., Bhatt A., Bianco C., Bidin F. N., Humaid F. B., Bin Kamarudin M. N., Blanco-Schweizer P., Bloos F., Boccia F., Bogaert D., Borges D., Bouhmani D., Bouziotis J., Boylan M., Bozza F. A., Brazzi L., Brewster D., Brickell K., Broadley T., Brozzi N., Buchtele N., Burrell A., Cabral S., Cabrita J., Garces R. C., Calligy K., Campbell P., Cardoso S., Cardoso F., Carelli S., Carrier F. M., Carson G., Cascao M., Casimiro J., Castanheira N., Castro I., Catarino A., Cavalin R., Cavalli G. G., Cavayas A., Chand M., Chen A., Chen Y. -S., Cheng M. P., Chica J., Chidambaram S. K., Tho L. C., Cho S. -M., Chow T. S., Chua H. J., Chua J., Cidade J. P., Citarella B. W., Ciullo A., Clarke J., Clohisey S., Codan C., Coles J., Colombo S. M., Connor M., Cooke G. S., Corley A., Cornelis S., Corpuz A. J., Crump J., Cruz C., Cruz Bermudez J. L., Rojo J. C., Csete M., Cullen A., Cummings M., Curley G., Custodio P., Filipe A. S., Dabaliz A. -A., Dagens A., Dahly D., Dalton J., Damas J., Dankwa E. A., Dantas J., de Loughry G., de Rosa R., de Silva T., Deacon J., Dean D., Debenedictis B., Dell'Amore A., Denis E., Depuydt P., Desai M., Dhangar P., Diaz R., Dieperink W., Docherty A. B., Doherty H., Donnelly C. A., Donohue C., Downer T., Drake T., Duculan T., Dunning J., Duplaix M., Durante-Mangoni E., Durham L., Ean S. C., Echeverria-Villalobos M., Elotmani L., Elshazly T., Eng C. C., Escher M., Santo C. E., Estevao J., Everding A. G., Fairfield C. J., Faria P., Fateena H., Fayed M., Fernandes J., Fernandes M. A., Fernandes S., Ferrao J., Ferraz M., Ferreira B., Figueiredo-Mello C., Fiorda J., Fletcher T., Florio L. L., Fonseca T., Forsyth S., Foti G., Fowler R. A., Fraser J. F., Fraser C., Ribeiro A. F., French C., Fukuda M., G A., Gagliardi M., Gaiao S., Gamble C., Gani Y., Garcia R., Barrio N. G., Gavin A., Germano N., Giani M., Gilroy E., Girvan M., Gnall E., Goffard J. -C., Goh J. Y., Golob J., Gonzalez A., Graf J., Grasselli G., Green C. A., Greenhalf W., Grieco D. L., Griffee M., Griffiths F., Lordemann A. G., Gruner H., Gu Y., Guerreiro D., Castro M. G., Hakak S., Hall M., Halpin S., Hamer A., Hammond T., Hammond N., Han L. Y., Hao K. W., Hardwick H., Ekow Harrison S. B., Harrison E. M., Harrison J., Heerman J., Hendry R., Hennessy M., Higgins D., Higgins R., Hinton S., Ho Y. B., Ho A., Hoh W. H., Holt R., Horby P., Hsu J. M. -Y., Hurd A., Ijaz S., Inacio H., Ing Y. S., Isgett S., Isidoro T., Ismail N., Ivulich D., Jackson C., Jelani A. M., Joe O. Y., Joshi S., Jung A., Kaisbain N., Kaleesvran T., Ayadi Kamaluddin M. A., Che Kamaruddin Z. A., Kamarudin N., Kang K. Y., Karpayah P., Kartsonaki C., Kay C., Keating S., Kelly A., Kelly S., Kennon K., Khalid I., Khan I., Kho M. E., Khoo R., Khoo D., Khoo S., Kiat K. H., Kida Y., Kim J. B., Kitamura N., Klenerman P., Knight S. R., Kobbe R., Krishnan V., Kumar D., Kumar G., Kurtzman E., Lalueza A., Lanza M., Law A., Lee T. C., Lee H. G., Lee B. H., Lee Y. L., Lee J., Leeming G., Lene H. S., Leone M., Bassi G. L., Lim K. C., Lim W. S., Lina L., Liu K., Loforte A., Loon L. C., Lopes D., Low L. L., Loy J. S., Bermejo C. L., Lunn M., Lyons R., Maasikas O., Machado S., de la Calle G. M., Maier L. S., Malfertheiner M., Malik N., Sant'ana Malaque C. M., Marino D., Marques A., Marsh B., Marsh L., Marshall J., Martin E., Martinez F. E., Martin-Loeches I., Martins J., Martins A., Rego C. M., Martucci G., Marzukie M., Maynar J., McArthur C., McCanny P., McCloskey C., McDermott S., McDonald S. E., McElroy A., McElwee S., McEvoy N., McKay C., McKeown J., McLean K. A., Mele F., Menkiti O., Mentzer A. J., Mergler B., Merson L., Mesquita A., Meynert A. M., Mihnovit V., Miller J., Misnan N. A., Mohamed T. J., Eliza Mohamed N. N., Moin A., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Motos A., Muh N. Y., Muhamad D., Murphy A., Murthy S., Muyandy G., Nagpal D., Nagrebetsky A., Neto R., Neumann E., Ng W. Y., Choileain O. N., Nichol A. D., Nitayavardhana P., Nonas S., Mohd Noordin N. A., Izzati Norharizam N. F., Norman L., Noursadeghi M., Occhipinti G., O'Donnell M., Ogura T., Oliveira J., Olliaro P. L., Ong J. Y., Oosthuyzen W., Openshaw P., Ortoleva J., Osatnik J., Othman S. Z., Palmarini M., Panarello G., Panda P. K., Pang L. H., Panigada M., Parke R., Patauner F., Pathmanathan M. D., Patterson L., Paulos J., Paxton W. A., Peake S. L., Peariasamy K., Jimenez M. P., Pelosi P., Pereira R., Periel L., Pesenti A., Pimentel C., Pires C., Pius R., Png H. S., Poli S., Pollakis G., Post A. -M., Postma D. F., Povoa P., Povoas D., Preiser J. -C., Pritchard M. G., Proenca L., Semedi B. P., Quesada L., Quinones-Cardona V., Gonzalez V. Q., Quraishi M., Rafael A., Rahman R. A., Rahman A. K. H. A., Rajahram G. S., Ramalho J., Ramli A. A., Ramos G. V., Rangappa R., Ratsep I., Rau C., Ravi T., Reis R., Rello J., Ren H., Richardson D., Ahmad Ridzuan S. N. A., Rios A. L., Robba C., Roberto A., Roberts S., Robertson D. L., Rodeia S., Roessler B., Roger C., Rojek A., Roncon-Albuquerque R., Rose M., Rosenberger D., Rossetti M., Russell C. D., Ryckaert S., Saba I., Sadat M., Sakiyalak P., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Santos M., Satyapriya S., Saviciute E., Saw Y. T., Schaffer J., Schermer T., Schwameis M., Scott J. T., Scott-Brown J., Selvarajoo M., Semple M. G., Senian R. B., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shahidan S. A., Shamsah M., Sharma P., Shaw C. A., Shaw V., Shetty R. M., Shi H., Shimizu H., Shimizu K., Shrapnel S., Shum H. P., Siang N. Y., Sigfrid L., Sillaots P., Silva C., Heng B. S. L., Singh P., Singh M., Sivam K., Smith S., Smood B., Smyth C., Snacken M., Soh T. V., Solomon J., Solomon T., Somers E., Song M. J., Sousa M., Uva M. S., Sperry A., Sriskandan S., Staudinger T., Stecher S. -S., Stienstra Y., Stolz E., Stuart A., Stuart D., Suen J. Y., Summers C., Suppiah D., Syahrin S., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Taib S. M., Taleb S., Talsma J., Tan K. K., Tan Y. C., Tedder R. S., Tee T. Y., Teixeira J., Tejada S., Teoh S. K., Terpstra P., Tessier-Grenier H., Thabit A. A. M., Tham Z. D., Thangavelu S., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thorpe M., Thurai S. R. T., Thwaites R. S., Toh J. Z. Y., Tonnii S. L., Torre M., Torres A., Towers M., Trapani T., Turtle L. C. W., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Val-Flores L., Van de Velde S., Van Der Vekens N., Van der Voort P., Vanoverschelde H., Vasudayan S. R., Veeran S., Ventura S., Vidal J. E., Vieira C., Villanueva J. A., Vitiello C., Wahab N. H., Wahab S. A., Wahid N. A., Wang C. -H., Webb S., Wei J., Wen T. P., Wham M., White N., Wille K., Williams B., Williams V., Williams P. J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Xian G. E., Xian L. S., Xuan K. P., Mohd Yakop S. R. B., Yamazaki M., Yarad E., Hing N. Y. L., Yeoh C. H., Yerkovich S., Yokoyama T., Zaaqoq A., Zahid M., Binti Zaidan N. 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B., Yamazaki M., Yarad E., Hing N. Y. L., Yeoh C. H., Yerkovich S., Yokoyama T., Zaaqoq A., Zahid M., Binti Zaidan N. Z., Zambon M., Zanella A., and Zaynah N.
- Abstract
Background: Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is a lifesaving support modality for severe respiratory failure, but its resource-intensive nature led to significant controversy surrounding its use during the COVID-19 pandemic. We report the performance of several ECMO mortality prediction and severity of illness scores at discriminating survival in a large COVID-19 V-V ECMO cohort. Methods: We validated ECMOnet, PRESET (PREdiction of Survival on ECMO Therapy-Score), Roch, SOFA (Sequential Organ Failure Assessment), APACHE II (acute physiology and chronic health evaluation), 4C (Coronavirus Clinical Characterisation Consortium), and CURB-65 (Confusion, Urea nitrogen, Respiratory Rate, Blood Pressure, age >65 years) scores on the ISARIC (International Severe Acute Respiratory and emerging Infection Consortium) database. We report discrimination via Area Under the Receiver Operative Curve (AUROC) and Area under the Precision Recall Curve (AURPC) and calibration via Brier score. Results: We included 1147 patients and scores were calculated on patients with sufficient variables. ECMO mortality scores had AUROC (0.58–0.62), AUPRC (0.62–0.74), and Brier score (0.286–0.303). Roch score had the highest accuracy (AUROC 0.62), precision (AUPRC 0.74) yet worst calibration (Brier score of 0.3) despite being calculated on the fewest patients (144). Severity of illness scores had AUROC (0.52–0.57), AURPC (0.59–0.64), and Brier Score (0.265–0.471). APACHE II had the highest accuracy (AUROC 0.58), precision (AUPRC 0.64), and best calibration (Brier score 0.26). Conclusion: Within a large international multicenter COVID-19 cohort, the evaluated ECMO mortality prediction and severity of illness scores demonstrated inconsistent discrimination and calibration highlighting the need for better clinically applicable decision support tools.
- Published
- 2023
24. Neurological manifestations of COVID-19 in adults and children
- Author
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S., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Streinu-Cercel A., Strudwick S., Stuart A., Stuart D., Suen G., Suen J. Y., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Tagherset L., Taib S. M., Talarek E., Taleb S., Talsma J., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka T., Taniguchi H., Taqdees H., Taqi A., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tellier M. -C., Teoh S. K., Teotonio V., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Thabit A. A. M., Tham Z. D., Thangavelu S., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson E. C., Thurai S. R. T., Thwaites R. S., Tierney P., Tieroshyn V., Timsit J. -F., Vijayaraghavan B. K. T., Tissot N., Toh J. Z. Y., Toki M., Tonby K., Tonnii S. L., Torres M., Torres A., Torres-Zevallos H., Towers M., Trapani T., Treoux T., Tromeur C., Trontzas I., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turmel J. -M., Turtle L. C. W., Tveita A., Twardowski P., Uchiyama M., Udayanga P. G. I., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Vajdovics C., Val-Flores L., Valran A., Velde S. V. D., Berge M. V. D., Feltz M. V. D., Palen J. V. D., Valk P. V. D., Vekens N. V. D., Voort P. V. D., Werf S. V. D., Gulik L. V., Hattem J. V., Netten C. V., Veen I. V., Vanel N., Vanoverschelde H., Varghese P., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vickers J., Vidal J. E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Visseaux B., Visser H., Vitiello C., Vonkeman H., Vuotto F., Wahab S. A., Wahid N. A., Shukeri W. F. W. M., Wang C. -H., Webb S., Wei J., Weil K., Wen T. P., Wesselius S., Wham M., Whelan B., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams V., Wils E. -J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Xian G. E., Xian L. S., Xuan K. P., Xynogalas I., Yakop S. R. B. M., Yamazaki M., Yazdanpanah Y., Hing N. Y. L., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zawadka K., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Different neurological manifestations of coronavirus disease 2019 (COVID-19) in adults and children and their impact have not been well characterized. We aimed to determine the prevalence of neurological manifestations and in-hospital complications among hospitalized COVID-19 patients and ascertain differences between adults and children. We conducted a prospective multicentre observational study using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) cohort across 1507 sites worldwide from 30 January 2020 to 25 May 2021. Analyses of neurological manifestations and neurological complications considered unadjusted prevalence estimates for predefined patient subgroups, and adjusted estimates as a function of patient age and time of hospitalization using generalized linear models. Overall, 161 239 patients (158 267 adults; 2972 children) hospitalized with COVID-19 and assessed for neurological manifestations and complications were included. In adults and children, the most frequent neurological manifestations at admission were fatigue (adults: 37.4%; children: 20.4%), altered consciousness (20.9%; 6.8%), myalgia (16.9%; 7.6%), dysgeusia (7.4%; 1.9%), anosmia (6.0%; 2.2%) and seizure (1.1%; 5.2%). In adults, the most frequent in-hospital neurological complications were stroke (1.5%), seizure (1%) and CNS infection (0.2%). Each occurred more frequently in intensive care unit (ICU) than in non-ICU patients. In children, seizure was the only neurological complication to occur more frequently in ICU versus non-ICU (7.1% versus 2.3%, P < 0.001). Stroke prevalence increased with increasing age, while CNS infection and seizure steadily decreased with age. There was a dramatic decrease in stroke over time during the pandemic. Hypertension, chronic neurological disease and the use of extracorporeal membrane oxygenation were associated with increased risk of stroke. Altered consciousness was associated with CNS infection, seizure and stroke.
- Published
- 2023
25. Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19
- Author
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R., Saba I., Sadaf S., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salahuddin N., Salazar L., Saleem J., Sales G., Sallaberry S., Salmon Gandonniere C., Salvator H., Sanchez O., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Santos M., Sarfo-Mensah S., Sarmento Banheiro B., Sarmiento I. C. E., Sarton B., Satya A., Satyapriya S., Satyawati R., Saviciute E., Savvidou P., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Schwartz G., Scicluna B., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvanayagam J., Selvarajoo M., Semaille C., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Serpa Neto A., Serrano Balazote P., Shadowitz E., Shahidan S. A., Shamsah M., Shankar A., Sharjeel S., Shaw C. A., Shaw V., Sheharyar A., Shetty R., Shetty R. M., Shi H., Shiban N., Shiekh M., Shime N., Shimizu H., Shimizu K., Shrapnel S., Shrestha P. S., Shrestha S. K., Shum H. P., Si Mohammed N., Siang N. Y., Sibiude J., Siddiqui A., Sillaots P., Silva C., Silva R., Silva M. J., Sin W. C., Sinatti D., Singh P., Singh B. C., Sitompul P. A., Sivam K., Skogen V., Smith S., Smood B., Smyth C., Smyth M., Snacken M., So D., Soh T. V., Solomon J., Solomon T., Sommet A., Song R., Song T., Song Chia J., Sonntagbauer M., Soom A. M., Sotto A., Soum E., Sousa M., Sousa A. C., Sousa Uva M., Souza-Dantas V., Sperry A., Spinuzza E., Sanka Ruwan Sri Darshana B. P., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Stuart D., Stuart A., Subekti D., Suen G., Suen J. Y., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Suwarti S., Svistunov A., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Tagherset L., Taib S. M., Talarek E., Taleb S., Talsma J., Tamisier R., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka T., Tanaka H., Taniguchi H., Taqdees H., Taqi A., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tejada S., Tellier M. -C., Teoh S. K., Teotonio V., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Thabit A. A. M., Thakur A., Tham Z. D., Thangavelu S., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson E. C., Thomson D., Thurai S. R. T., Thwaites R. S., Tierney P., Tieroshyn V., Timashev P. S., Timsit J. -F., Tissot N., Toh J. Z. Y., Toki M., Tonby K., Tonnii S. L., Torres M., Torres A., Torres Santos-Olmo R. M., Torres-Zevallos H., Towers M., Trapani T., Treoux T., Tromeur C., Trontzas I., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turmel J. -M., Turtle L. C. W., Tveita A., Twardowski P., Uchiyama M., Udayanga P. G. I., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Vajdovics C., Valentini P., Val-Flores L., Valran A., Van De Velde S., van Den Berge M., Van Der Feltz M., van Der Palen J., van Der Valk P., Van Der Vekens N., Van Der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Someren Greve F., van Veen I., Van Willigen H., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vickers J., Vidal J. E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Vishwanathan G., Visseaux B., Visser H., Vitiello C., Vonkeman H., Vuotto F., Wahab S. A., Wahab N. H., Wahid N. A., Wainstein M., Wan Muhd Shukeri W. F., Wang C. -H., Webb S., Weil K., Wen T. P., Wesselius S., West T. E., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams V., Wong C., Wong Y. S., Wong T. F., Wright N., Xian G. E., Xian L. S., Xuan K. P., Xynogalas I., Yakop S. R. B. M., Yamazaki M., Yazdanpanah Y., Yee Liang Hing N., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zawadka K., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world’s largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ~30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who hav
- Published
- 2023
26. Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
- Author
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B., Matan M., Mathieu D., Mattei M., Maulin L., Maxwell M., Maynar J., Mazzoni T., Sweeney L. M., McArthur C., McCanny P., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McEvoy N., McGeer A., McKay C., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Mehkri O., Mele F., Melo L., Mendes J. J., Menon K., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miller J., Miranda-Maldonado H., Misnan N. A., Mohamed T. J., Eliza Mohamed N. N., Moin A., Molinos E., Molloy B., Monahan S., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Cely L. M., Moro L., Morton B., Motherway C., Motos A., Mouquet H., Perrot C. M., Moyet J., Mudara C., Muh N. 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B., Matan M., Mathieu D., Mattei M., Maulin L., Maxwell M., Maynar J., Mazzoni T., Sweeney L. M., McArthur C., McCanny P., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McEvoy N., McGeer A., McKay C., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Mehkri O., Mele F., Melo L., Mendes J. J., Menon K., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miller J., Miranda-Maldonado H., Misnan N. A., Mohamed T. J., Eliza Mohamed N. N., Moin A., Molinos E., Molloy B., Monahan S., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Cely L. M., Moro L., Morton B., Motherway C., Motos A., Mouquet H., Perrot C. M., Moyet J., Mudara C., Muh N. 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R., Yamazaki M., Yarad E., Yazdanpanah Y., Liang Hing N. Y., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Binti Zaidan N. Z., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were mo
- Published
- 2023
27. A multi-country analysis of COVID-19 hospitalizations by vaccination status
- Author
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Knight, S, Korten, V, Kosgei, C, Kumar, D, Kutsogiannis, D, Lamontagne, F, Lanza, M, Law, A, Lawrence, T, Lee, J, Lee, T, Leeming, G, Letizia, A, Bassi, G, Liang, J, Lim, W, Lind, A, Lissauer, S, Lopes, D, Lyons, R, Machado, S, Majeed, N, Manetta, F, Sant`Ana Malaque, C, Marquis, C, Marsh, L, Marshall, J, Martin-Quiros, A, Martins, A, Rego, C, Martucci, G, Maslove, D, Matthew, C, Mayxay, M, Mcarthur, C, Mccarthy, A, Mcconnochie, R, Mcdonald, S, Mcgeer, A, Mckay, C, Mclean, K, Menon, K, Mentzer, A, Mesquita, A, Meyer, D, Meynert, A, Mihelis, E, Monteiro, A, Montrucchio, G, Moore, S, Cely, L, Moro, L, Morton, B, Mudara, C, Muhaisen, M, Muller, F, Muller, K, Munshi, L, Murthy, S, Mustafa, D, Nagpal, D, Narasimhan, M, Nasa, P, Nelder, M, Neumann, E, Ng, P, Nichol, A, Norman, L, Notari, A, Noursadeghi, M, Nusantara, D, Occhipinti, G, O'Hearn, K, Oliveira, L, Ong, D, Oosthuyzen, W, Openshaw, P, Palmarini, M, Panarello, G, Panda, P, Parke, R, Patricio, P, Patterson, L, Paul, M, Paulos, J, Paxton, W, Pejkovska, M, Pereira, R, Petrovic, M, Pettersen, F, Pharand, S, Phonemixay, O, Phoutthavong, S, de Piero, M, Pimentel, C, Pires, C, Pitaloka, A, Pius, R, Poli, S, Pollakis, G, Post, A, Povoas, D, Powis, J, Praphasiri, V, Pritchard, M, Semedi, B, Purcell, G, Quesada, L, Quist-Paulsen, E, Rafael, A, Rahardjani, M, Ramalho, J, Rangappa, R, Ratsep, I, Reeve, B, Reikvam, D, Ren, H, Rewa, O, Ricchiuto, A, Rishu, A, Rivera Nunez, M, Roberts, S, Robertson, D, Roche-Campo, F, Rodari, P, Roessler, B, Rossanese, A, Rossetti, M, Russell, C, Holten, A, Saba, I, Sadat, M, Sahraei, V, Salazar, L, Sales, G, Sanchez, E, Sancho-Shimizu, V, Sandhu, G, Sandulescu, O, Santos, M, Sarfo-Mensah, S, Sarmiento, I, Saviciute, E, Schaffer, J, Schwameis, M, Schwartz, G, Scott, J, Scott-Brown, J, Semple, M, Sequeira, T, Shadowitz, E, Shankar, A, Shaw, C, Shaw, V, Mohan Shetty, D, Sibounheuang, B, Sigfrid, L, Sillaots, P, Sin, W, Sinatti, D, Singh, M, Skogen, V, Smith, S, Solomon, J, Solomon, T, Song, R, Spinuzza, E, Sriskandan, S, Staudinger, T, Stecher, S, Steinsvik, T, Stiksrud, B, Streinu-Cercel, A, Stuart, D, Subekti, D, Suen, J, Sultana, A, Summers, C, Suwarti, A, Sztajnbok, J, Tabrizi, S, Taleb, S, Tedder, R, Teixeira, J, Tessier-Grenier, H, Thompson, S, Thomson, E, Thorpe, M, Thwaites, R, Tonby, K, Torre, M, Torres Santos-Olmo, R, Turgeon, A, Turtle, L, Tveita, A, Twardowski, P, Ullrich, R, Uyeki, T, Valentini, P, Val-Flores, L, Varrone, M, Vidal, J, Vieira, C, Villanueva, J, Villar, J, Villoldo, A, Vitiello, C, Vongsouvath, M, Wainstein, M, Webb, S, Wei, J, Wesselius, S, Wham, M, White, N, Willems, S, Williams, B, Williams, V, Wils, E, Wittman, J, Yerkovich, S, Yiaye, T, Zahran, M, Zambon, M, Goncalves B. P., Jassat W., Baruch J., Hashmi M., Rojek A., Dasgupta A., Martin-Loeches I., Reyes L. F., Piubelli C., Citarella B. W., Kartsonaki C., Lefevre B., Lopez Revilla J. W., Lunn M., Harrison E. M., Kraemer M. U. G., Shrapnel S., Horby P., Bisoffi Z., Olliaro P. L., Merson L., Abdukahil S. A., Jabal K. A., Salah N. A., Airlangga E., Hssain A. A., Akwani C., Al Qasim E., Alberti A., Aldabbourosama O., Alessi M., Alex B., Al-Fares A., Aliudin J., Alkahlout M., Almasri L., Al-Saba'a Y., Alves R., Cabrita J. A., Amaral M., Ampaw P., Anchan A. J., Angheben A., Arabi Y., Arcadipane A., Archambault P., Arenz L., Arora R., Ashley E. A., Atique A., Atlowly M., Bach B., Baillie J. K., Baird J. K., Balan V., Barbalho R., Barbosa N. Y., Barclay W. S., Barnikel M., Beer N., Begum H., Bellemare D., Beltrame A., Bertoli G., Bianco C., Humaid F. B., Bitton J., Blier C., Bogaert D., Borges D., Bouhmani D., Bounphiengsy T., Bountthasavong L., Klerk B. B. -D., Monteiro F. B., Brazzi L., Buchtele N., Buonsenso D., Burrell A., Bustos I. G., Cabrita J., Caceres E., Garces R. C., Campisi J., Canepa C., Caoili J., Cardellino C. S., Cardoso F., Cardoso S., Carney G., Carrier F. M., Carson G., Cascao M., Casimiro J., Castaneda S., Castanheira N., Cattaneo P., Cavalin R., Cavayas A., Cevik M., Chaleunphon B., Chan A., Chand M., Chen A., Cheng M. P., Chommanam D., Chow Y. P., Christy N., Claure-Del Granado R., Clohisey S., Codan C., Connor M., Cooke G. S., Copland M., Corley A., Cortegiani A., Crowl G., Cruz C., Csete M., Custodio P., da Silva Filipe A., Dagens A., Daley P., Dalloul Z., Dalton H., Dalton J., Damas J., Daneman N., Dankwa E. A., Dantas J., D'Aragon F., De Rose C., de Silva T., Dechert W., Denis E., Dishon Y., k Dhangar, Docherty A. B., Donnelly C. A., Donohue C., Douangdala P., Douglas J. J., Downer T., Downing M., Drake T., Dryden M., Dubot-Peres A., Dudman S., Dunning J., Duplaix M., Durham L., Dyrhol-Riise A. M., Edelstein M., Escher M., Esperatti M., Santo C. E., Estevao J., Faheem A., Fairfield C. J., Faria P., Farshait N., Fernandes J., Fernandes M. A., Ferrao J., Ferraz M., Ferreira B., Figueiredo-Mello C., Fletcher T., Flynn B., Fontela P., Forsyth S., Foti G., Fowler R. A., Franch-Llasat D., Fraser C., Fraser J. F., Ribeiro A. F., Friedrich C., Fuentes N., G A., Skeie L. G., Gamble C., Garces R., Garcia-Diaz J., Garcia-Gallo E., Gavin A., Germano N., Ghadimi M., Ghisulal P. K., Giani M., Gibson J., Girvan M., Goco G., Gomez-Junyent J., Grable M., Green C. A., Greenhalf W., Griffiths F., Gruner H., Gu Y., Guerguerian A. -M., Guerreiro D., Haber D., Habraken H., Hafez W., Hall M., Halpin S., Hamdan S., Hamers R. L., Hamza S., Hardwick H., Harrison J., Hartman A., Heggelund L., Hendry R., Hennessy M., Hesstvedt L., Higgins D., Higgins R., Hinton S., Ho A., Holter J. C., Horcajada J. P., Ming-Yang Hsu J., Hurd A., Ijaz S., Illana C. C., Inacio H., Ippolito M., Isidoro T., Jaber H., Jackson C., Jaworsky D., Jenum S., Jouvet P., Kalicinska A., Kandel C., Katz K., Kaur A., Keating S., Kelly A., Kelly S., Kennon K., Keomany S., Khalid I., Kho M. E., Khoo S., Kiiza P., Granerud B. K., Kildal A. B., Klenerman P., Bekken G. K., Knight S. R., Korten V., Kosgei C., Kumar D., Kutsogiannis D., Lamontagne F., Lanza M., Law A., Lawrence T., Lee J., Lee T. C., Leeming G., Letizia A., Bassi G. L., Liang J., Lim W. S., Lind A., Lissauer S., Lopes D., Lyons R., Machado S., Majeed N. A., Manetta F., Sant`Ana Malaque C. M., Marquis C., Marsh L., Marshall J., Martin-Quiros A., Martins A., Rego C. M., Martucci G., Maslove D., Matthew C., Mayxay M., McArthur C., McCarthy A., McConnochie R., McDonald S. E., McGeer A., McKay C., McLean K. A., Menon K., Mentzer A. J., Mesquita A., Meyer D., Meynert A. M., Mihelis E., Monteiro A., Montrucchio G., Moore S., Moore S. C., Cely L. M., Moro L., Morton B., Mudara C., Muhaisen M., Muller F., Muller K. E., Munshi L., Murthy S., Mustafa D., Nagpal D., Narasimhan M., Nasa P., Nelder M., Neumann E., Ng P. Y., Nichol A. D., Norman L., Notari A., Noursadeghi M., Nusantara D. U., Occhipinti G., O'Hearn K., Oliveira L., Ong D. S. Y., Oosthuyzen W., Openshaw P., Palmarini M., Panarello G., Panda P. K., Parke R., Patricio P., Patterson L., Paul M., Paulos J., Paxton W. A., Pejkovska M., Pereira R., Petrovic M., Pettersen F. O., Pharand S., Phonemixay O., Phoutthavong S., de Piero M., Pimentel C., Pires C., Pitaloka A., Pius R., Poli S., Pollakis G., Post A. -M., Povoas D., Powis J., Praphasiri V., Pritchard M. G., Semedi B. P., Purcell G., Quesada L., Quist-Paulsen E., Rafael A., Rahardjani M., Ramalho J., Rangappa R., Ratsep I., Reeve B., Reikvam D. H., Ren H., Rewa O., Ricchiuto A., Rishu A., Rivera Nunez M. A., Roberts S., Robertson D. L., Roche-Campo F., Rodari P., Roessler B., Rossanese A., Rossetti M., Russell C. D., Holten A. R., Saba I., Sadat M., Sahraei V., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmiento I. C. E., Saviciute E., Schaffer J., Schwameis M., Schwartz G., Scott J. T., Scott-Brown J., Semple M. G., Sequeira T., Shadowitz E., Shankar A., Shaw C. A., Shaw V., Mohan Shetty D. R., Sibounheuang B., Sigfrid L., Sillaots P., Sin W. C., Sinatti D., Singh M., Skogen V., Smith S., Solomon J., Solomon T., Song R., Spinuzza E., Sriskandan S., Staudinger T., Stecher S. -S., Steinsvik T., Stiksrud B., Streinu-Cercel A., Stuart D., Subekti D., Suen J. Y., Sultana A., Summers C., Suwarti A., Sztajnbok J., Tabrizi S., Taleb S., Tedder R. S., Teixeira J., Tessier-Grenier H., Thompson S., Thomson E. C., Thorpe M., Thwaites R. S., Tonby K., Torre M., Torres Santos-Olmo R. M., Turgeon A. F., Turtle L. C. W., Tveita A., Twardowski P., Ullrich R., Uyeki T. M., Valentini P., Val-Flores L., Varrone M., Vidal J. E., Vieira C., Villanueva J. A., Villar J., Villoldo A., Vitiello C., Vongsouvath M., Wainstein M., Webb S., Wei J., Wesselius S., Wham M., White N., Willems S., Williams B., Williams V., Wils E. -J., Wittman J., Yerkovich S., Yiaye T., Zahran M., Zambon M., Goncalves, B, Jassat, W, Baruch, J, Hashmi, M, Rojek, A, Dasgupta, A, Martin-Loeches, I, Reyes, L, Piubelli, C, Citarella, B, Kartsonaki, C, Lefevre, B, Lopez Revilla, J, Lunn, M, Harrison, E, Kraemer, M, Shrapnel, S, Horby, P, Bisoffi, Z, Olliaro, P, Merson, L, Abdukahil, S, Jabal, K, Salah, N, Airlangga, E, Hssain, A, Akwani, C, Al Qasim, E, Alberti, A, Aldabbourosama, O, Alessi, M, Alex, B, Al-Fares, A, Aliudin, J, Alkahlout, M, Almasri, L, Al-Saba'a, Y, Alves, R, Cabrita, J, Amaral, M, Ampaw, P, Anchan, A, Angheben, A, Arabi, Y, Arcadipane, A, Archambault, P, Arenz, L, Arora, R, Ashley, E, Atique, A, Atlowly, M, Bach, B, Baillie, J, Baird, J, Balan, V, Barbalho, R, Barbosa, N, Barclay, W, Barnikel, M, Beer, N, Begum, H, Bellemare, D, Beltrame, A, Bertoli, G, Bianco, C, Humaid, F, Bitton, J, Blier, C, Bogaert, D, Borges, D, Bouhmani, D, Bounphiengsy, T, Bountthasavong, L, Klerk, B, Monteiro, F, Brazzi, L, Buchtele, N, Buonsenso, D, Burrell, A, Bustos, I, Caceres, E, Garces, R, Campisi, J, Canepa, C, Caoili, J, Cardellino, C, Cardoso, F, Cardoso, S, Carney, G, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castaneda, S, Castanheira, N, Cattaneo, P, Cavalin, R, Cavayas, A, Cevik, M, Chaleunphon, B, Chan, A, Chand, M, Chen, A, Cheng, M, Chommanam, D, Chow, Y, Christy, N, Claure-Del Granado, R, Clohisey, S, Codan, C, Connor, M, Cooke, G, Copland, M, Corley, A, Cortegiani, A, Crowl, G, Cruz, C, Csete, M, Custodio, P, da Silva Filipe, A, Dagens, A, Daley, P, Dalloul, Z, Dalton, H, Dalton, J, Damas, J, Daneman, N, Dankwa, E, Dantas, J, D'Aragon, F, De Rose, C, de Silva, T, Dechert, W, Denis, E, Dishon, Y, K, D, Docherty, A, Donnelly, C, Donohue, C, Douangdala, P, Douglas, J, Downer, T, Downing, M, Drake, T, Dryden, M, Dubot-Peres, A, Dudman, S, Dunning, J, Duplaix, M, Durham, L, Dyrhol-Riise, A, Edelstein, M, Escher, M, Esperatti, M, Santo, C, Estevao, J, Faheem, A, Fairfield, C, Faria, P, Farshait, N, Fernandes, J, Fernandes, M, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fletcher, T, Flynn, B, Fontela, P, Forsyth, S, Foti, G, Fowler, R, Franch-Llasat, D, Fraser, C, Fraser, J, Ribeiro, A, Friedrich, C, Fuentes, N, G, A, Skeie, L, Gamble, C, Garcia-Diaz, J, Garcia-Gallo, E, Gavin, A, Germano, N, Ghadimi, M, Ghisulal, P, Giani, M, Gibson, J, Girvan, M, Goco, G, Gomez-Junyent, J, Grable, M, Green, C, Greenhalf, W, Griffiths, F, Gruner, H, Gu, Y, Guerguerian, A, Guerreiro, D, Haber, D, Habraken, H, Hafez, W, Hall, M, Halpin, S, Hamdan, S, Hamers, R, Hamza, S, Hardwick, H, Harrison, J, Hartman, A, Heggelund, L, Hendry, R, Hennessy, M, Hesstvedt, L, Higgins, D, Higgins, R, Hinton, S, Ho, A, Holter, J, Horcajada, J, Ming-Yang Hsu, J, Hurd, A, Ijaz, S, Illana, C, Inacio, H, Ippolito, M, Isidoro, T, Jaber, H, Jackson, C, Jaworsky, D, Jenum, S, Jouvet, P, Kalicinska, A, Kandel, C, Katz, K, Kaur, A, Keating, S, Kelly, A, Kelly, S, Kennon, K, Keomany, S, Khalid, I, Kho, M, Khoo, S, Kiiza, P, Granerud, B, Kildal, A, Klenerman, P, Bekken, G, Knight, S, Korten, V, Kosgei, C, Kumar, D, Kutsogiannis, D, Lamontagne, F, Lanza, M, Law, A, Lawrence, T, Lee, J, Lee, T, Leeming, G, Letizia, A, Bassi, G, Liang, J, Lim, W, Lind, A, Lissauer, S, Lopes, D, Lyons, R, Machado, S, Majeed, N, Manetta, F, Sant`Ana Malaque, C, Marquis, C, Marsh, L, Marshall, J, Martin-Quiros, A, Martins, A, Rego, C, Martucci, G, Maslove, D, Matthew, C, Mayxay, M, Mcarthur, C, Mccarthy, A, Mcconnochie, R, Mcdonald, S, Mcgeer, A, Mckay, C, Mclean, K, Menon, K, Mentzer, A, Mesquita, A, Meyer, D, Meynert, A, Mihelis, E, Monteiro, A, Montrucchio, G, Moore, S, Cely, L, Moro, L, Morton, B, Mudara, C, Muhaisen, M, Muller, F, Muller, K, Munshi, L, Murthy, S, Mustafa, D, Nagpal, D, Narasimhan, M, Nasa, P, Nelder, M, Neumann, E, Ng, P, Nichol, A, Norman, L, Notari, A, Noursadeghi, M, Nusantara, D, Occhipinti, G, O'Hearn, K, Oliveira, L, Ong, D, Oosthuyzen, W, Openshaw, P, Palmarini, M, Panarello, G, Panda, P, Parke, R, Patricio, P, Patterson, L, Paul, M, Paulos, J, Paxton, W, Pejkovska, M, Pereira, R, Petrovic, M, Pettersen, F, Pharand, S, Phonemixay, O, Phoutthavong, S, de Piero, M, Pimentel, C, Pires, C, Pitaloka, A, Pius, R, Poli, S, Pollakis, G, Post, A, Povoas, D, Powis, J, Praphasiri, V, Pritchard, M, Semedi, B, Purcell, G, Quesada, L, Quist-Paulsen, E, Rafael, A, Rahardjani, M, Ramalho, J, Rangappa, R, Ratsep, I, Reeve, B, Reikvam, D, Ren, H, Rewa, O, Ricchiuto, A, Rishu, A, Rivera Nunez, M, Roberts, S, Robertson, D, Roche-Campo, F, Rodari, P, Roessler, B, Rossanese, A, Rossetti, M, Russell, C, Holten, A, Saba, I, Sadat, M, Sahraei, V, Salazar, L, Sales, G, Sanchez, E, Sancho-Shimizu, V, Sandhu, G, Sandulescu, O, Santos, M, Sarfo-Mensah, S, Sarmiento, I, Saviciute, E, Schaffer, J, Schwameis, M, Schwartz, G, Scott, J, Scott-Brown, J, Semple, M, Sequeira, T, Shadowitz, E, Shankar, A, Shaw, C, Shaw, V, Mohan Shetty, D, Sibounheuang, B, Sigfrid, L, Sillaots, P, Sin, W, Sinatti, D, Singh, M, Skogen, V, Smith, S, Solomon, J, Solomon, T, Song, R, Spinuzza, E, Sriskandan, S, Staudinger, T, Stecher, S, Steinsvik, T, Stiksrud, B, Streinu-Cercel, A, Stuart, D, Subekti, D, Suen, J, Sultana, A, Summers, C, Suwarti, A, Sztajnbok, J, Tabrizi, S, Taleb, S, Tedder, R, Teixeira, J, Tessier-Grenier, H, Thompson, S, Thomson, E, Thorpe, M, Thwaites, R, Tonby, K, Torre, M, Torres Santos-Olmo, R, Turgeon, A, Turtle, L, Tveita, A, Twardowski, P, Ullrich, R, Uyeki, T, Valentini, P, Val-Flores, L, Varrone, M, Vidal, J, Vieira, C, Villanueva, J, Villar, J, Villoldo, A, Vitiello, C, Vongsouvath, M, Wainstein, M, Webb, S, Wei, J, Wesselius, S, Wham, M, White, N, Willems, S, Williams, B, Williams, V, Wils, E, Wittman, J, Yerkovich, S, Yiaye, T, Zahran, M, Zambon, M, Goncalves B. P., Jassat W., Baruch J., Hashmi M., Rojek A., Dasgupta A., Martin-Loeches I., Reyes L. F., Piubelli C., Citarella B. W., Kartsonaki C., Lefevre B., Lopez Revilla J. W., Lunn M., Harrison E. M., Kraemer M. U. G., Shrapnel S., Horby P., Bisoffi Z., Olliaro P. L., Merson L., Abdukahil S. A., Jabal K. A., Salah N. A., Airlangga E., Hssain A. A., Akwani C., Al Qasim E., Alberti A., Aldabbourosama O., Alessi M., Alex B., Al-Fares A., Aliudin J., Alkahlout M., Almasri L., Al-Saba'a Y., Alves R., Cabrita J. A., Amaral M., Ampaw P., Anchan A. J., Angheben A., Arabi Y., Arcadipane A., Archambault P., Arenz L., Arora R., Ashley E. A., Atique A., Atlowly M., Bach B., Baillie J. K., Baird J. K., Balan V., Barbalho R., Barbosa N. Y., Barclay W. S., Barnikel M., Beer N., Begum H., Bellemare D., Beltrame A., Bertoli G., Bianco C., Humaid F. B., Bitton J., Blier C., Bogaert D., Borges D., Bouhmani D., Bounphiengsy T., Bountthasavong L., Klerk B. B. -D., Monteiro F. B., Brazzi L., Buchtele N., Buonsenso D., Burrell A., Bustos I. G., Cabrita J., Caceres E., Garces R. C., Campisi J., Canepa C., Caoili J., Cardellino C. S., Cardoso F., Cardoso S., Carney G., Carrier F. M., Carson G., Cascao M., Casimiro J., Castaneda S., Castanheira N., Cattaneo P., Cavalin R., Cavayas A., Cevik M., Chaleunphon B., Chan A., Chand M., Chen A., Cheng M. P., Chommanam D., Chow Y. P., Christy N., Claure-Del Granado R., Clohisey S., Codan C., Connor M., Cooke G. S., Copland M., Corley A., Cortegiani A., Crowl G., Cruz C., Csete M., Custodio P., da Silva Filipe A., Dagens A., Daley P., Dalloul Z., Dalton H., Dalton J., Damas J., Daneman N., Dankwa E. A., Dantas J., D'Aragon F., De Rose C., de Silva T., Dechert W., Denis E., Dishon Y., k Dhangar, Docherty A. B., Donnelly C. A., Donohue C., Douangdala P., Douglas J. J., Downer T., Downing M., Drake T., Dryden M., Dubot-Peres A., Dudman S., Dunning J., Duplaix M., Durham L., Dyrhol-Riise A. M., Edelstein M., Escher M., Esperatti M., Santo C. E., Estevao J., Faheem A., Fairfield C. J., Faria P., Farshait N., Fernandes J., Fernandes M. A., Ferrao J., Ferraz M., Ferreira B., Figueiredo-Mello C., Fletcher T., Flynn B., Fontela P., Forsyth S., Foti G., Fowler R. A., Franch-Llasat D., Fraser C., Fraser J. F., Ribeiro A. F., Friedrich C., Fuentes N., G A., Skeie L. G., Gamble C., Garces R., Garcia-Diaz J., Garcia-Gallo E., Gavin A., Germano N., Ghadimi M., Ghisulal P. K., Giani M., Gibson J., Girvan M., Goco G., Gomez-Junyent J., Grable M., Green C. A., Greenhalf W., Griffiths F., Gruner H., Gu Y., Guerguerian A. -M., Guerreiro D., Haber D., Habraken H., Hafez W., Hall M., Halpin S., Hamdan S., Hamers R. L., Hamza S., Hardwick H., Harrison J., Hartman A., Heggelund L., Hendry R., Hennessy M., Hesstvedt L., Higgins D., Higgins R., Hinton S., Ho A., Holter J. C., Horcajada J. P., Ming-Yang Hsu J., Hurd A., Ijaz S., Illana C. C., Inacio H., Ippolito M., Isidoro T., Jaber H., Jackson C., Jaworsky D., Jenum S., Jouvet P., Kalicinska A., Kandel C., Katz K., Kaur A., Keating S., Kelly A., Kelly S., Kennon K., Keomany S., Khalid I., Kho M. E., Khoo S., Kiiza P., Granerud B. K., Kildal A. B., Klenerman P., Bekken G. K., Knight S. R., Korten V., Kosgei C., Kumar D., Kutsogiannis D., Lamontagne F., Lanza M., Law A., Lawrence T., Lee J., Lee T. C., Leeming G., Letizia A., Bassi G. L., Liang J., Lim W. S., Lind A., Lissauer S., Lopes D., Lyons R., Machado S., Majeed N. A., Manetta F., Sant`Ana Malaque C. M., Marquis C., Marsh L., Marshall J., Martin-Quiros A., Martins A., Rego C. M., Martucci G., Maslove D., Matthew C., Mayxay M., McArthur C., McCarthy A., McConnochie R., McDonald S. E., McGeer A., McKay C., McLean K. A., Menon K., Mentzer A. J., Mesquita A., Meyer D., Meynert A. M., Mihelis E., Monteiro A., Montrucchio G., Moore S., Moore S. C., Cely L. 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D., Holten A. R., Saba I., Sadat M., Sahraei V., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmiento I. C. E., Saviciute E., Schaffer J., Schwameis M., Schwartz G., Scott J. T., Scott-Brown J., Semple M. G., Sequeira T., Shadowitz E., Shankar A., Shaw C. A., Shaw V., Mohan Shetty D. R., Sibounheuang B., Sigfrid L., Sillaots P., Sin W. C., Sinatti D., Singh M., Skogen V., Smith S., Solomon J., Solomon T., Song R., Spinuzza E., Sriskandan S., Staudinger T., Stecher S. -S., Steinsvik T., Stiksrud B., Streinu-Cercel A., Stuart D., Subekti D., Suen J. Y., Sultana A., Summers C., Suwarti A., Sztajnbok J., Tabrizi S., Taleb S., Tedder R. S., Teixeira J., Tessier-Grenier H., Thompson S., Thomson E. C., Thorpe M., Thwaites R. S., Tonby K., Torre M., Torres Santos-Olmo R. M., Turgeon A. F., Turtle L. C. W., Tveita A., Twardowski P., Ullrich R., Uyeki T. M., Valentini P., Val-Flores L., Varrone M., Vidal J. E., Vieira C., Villanueva J. A., Villar J., Villoldo A., Vitiello C., Vongsouvath M., Wainstein M., Webb S., Wei J., Wesselius S., Wham M., White N., Willems S., Williams B., Williams V., Wils E. -J., Wittman J., Yerkovich S., Yiaye T., Zahran M., and Zambon M.
- Abstract
Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes. Methods: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed. Findings: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed. Conclusions: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. Funding: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the “acknowledgments” section.
- Published
- 2023
28. Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
- Author
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L., Houltham S., Ming-Yang Hsu J., Hulot J. -S., Hurd A., Ijaz S., Ikram M. A., Illes H. -G., Imbert P., Inacio H., Ing Y. S., Ippolito M., Isgett S., Isidoro T., Ismail N., Isnard M., Itai J., Ivulich D., Jaafar D., Jaafoura S., Jabot J., Jackson C., Jaquet P., Jassat W., Jaud-Fischer C., Jaureguiberry S., Jego F., Jelani A. M., Jenum S., Joe O. Y., Jorge Garcia R. N., Joseph M., Joseph C., Jourdain M., Jouvet P., Jung A., Juzar D., Kafif O., Kaguelidou F., Kaisbain N., Kaleesvran T., Kali S., Kalomoiri S., Ayadi Kamaluddin M. A., Che Kamaruddin Z. A., Kamarudin N., Kandamby D. H., Kandel C., Kang K. Y., Karpayah P., Kartsonaki C., Kasugai D., Kataria A., Katz K., Kaur A., Kay C., Kayyali L., Keating S., Kelly C., Kelly Y., Kelly A., Kelly N., Kelly S., Kelsey M., Kennedy R., Kennon K., Kernan M., Kerroumi Y., Keshav S., Khalid I., Khalil A., Khan C., Khan I., Kho M. E., Khoo S., Khoo R., Khoo D., Kiat K. H., Kida Y., Kiiza P., Granerud B. K., Kildal A. B., Kim J. B., Kimmoun A., Kitamura N., Klenerman P., Klont R., Bekken G. K., Knight S. R., Komatsu M., Korten V., Kpangon A., Krawczyk K., Krishnan S., Krishnan V., Kruglova O., Kumar D., Kumar G., Tirupakuzhi Vijayaraghavan B. K., Vecham P. K., Kuriakose D., Kurtzman E., Kutsogiannis D., Kutsyna G., Kyriakoulis K., Lachatre M., Lacoste M., Laffey J. G., Lafhej N., Lagrange M., Laine F., Lairez O., Lalueza A., Lambert M., Langelot-Richard M., Langlois V., Lantang E. Y., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence T., Lawrence C., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Le Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Lee T. C., Lee S. H., Lee J., Lee H. G., Lee B. H., Lee Y. L., Leeming G., Lefebvre L., Lefebvre B., Lefevre B., LeGac S., Lelievre J. -D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lene H. S., Leone M., Lepiller Q., Lescure F. -X., Lesens O., Lesouhaitier M., Lester-Grant A., Letrou S., Levy Y., Levy B., Levy-Marchal C., L'Her E., Bassi G. L., Liang J., Liegeon G., Lim W. S., Lim K. C., Lima C., Lina B., Lina L., Lind A., Lingas G., Lion-Daolio S., Liu K., Livrozet M., Lizotte P., Lolong N., Loon L. C., Lopes D., Lopez-Colon D., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Low L., Lowik M., Loy J. S., Lucet J. C., Bermejo C. L., Luna C. M., Lungu O., Lunn M., Luong L., Luque N., Luton D., Lyons R., Maasikas O., Mabiala O., Machado S., Machado M., Macheda G., Madiha H., Maestro de la Calle G., Mahieu R., Mahy S., Maier L. S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Malvy D., Manda V., Mandelbrot L., Manetta F., Mankikian J., Manning E., Manuel A., Sant'Ana Malaque C. M., Marino F., Markowicz S., Marques A., Marsh B., Marsh L., Marshal M., Marshall J., Martelli C. T., Martin E., Martin-Blondel G., Martinez F. E., Martin-Loeches I., Martinot M., Martins J., Martins A., Rego C. M., Martucci G., Martynenko O., Marwali E. M., Marzukie M., Maslove D., Mason S., Mat Nor M. B., Matan M., Mathieu D., Mattei M., Maulin L., Maxwell M., Mazzoni T., Sweeney L. M., McArthur C., McCanny P., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McEvoy N., McGeer A., McKay C., McKeown J., McLean K. A., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Mehkri O., Mele F., Menon K., Mentre F., Mentzer A. J., Mercier N., Mercier E., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miller J., Misnan N. A., Mohamed T. J., Eliza Mohamed N. N., Moin A., Molinos E., Molloy B., Monahan S., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Cely L. M., Moro L., Motherway C., Motos A., Mouquet H., Perrot C. M., Moyet J., Mudara C., Muh N. Y., Muhamad D., Mullaert J., Muller F., Muller K. E., Munblit D., Murphy A., Murphy L., Murray P., Murris M., Murthy S., Musaab H., Muyandy G., Myrodia D. M., Nagpal D., Nagrebetsky A., Narasimhan M., Narayanan N., Neant N., Necsoi C., Nekliudov N., Neto R., Neumann E., Ng P. Y., Ng W. Y., Nghi A., Nguyen D., Choileain O. N., Leathlobhair N. N., Nichol A. D., Nitayavardhana P., Nonas S., Mohd Noordin N. A., Noret M., Izzati Norharizam N. F., Norman L., Notari A., Noursadeghi M., Nseir S., Nusantara D. U., Nyamankolly E., Brien F. O., Callaghan A. O., O'Callaghan A., Occhipinti G., OConnor D., Ogura T., O'Halloran S., O'Hearn K., Ohshimo S., Oliveira J., Olliaro P. L., O'Neil C., Ong D. S. Y., Ong J. Y., Oosthuyzen W., Opavsky A., Openshaw P., Orozco-Chamorro C. M., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Othman S. Z., Ouamara N., Ouissa R., Oziol E., Pagadoy M., Pages J., Palmarini M., Panarello G., Panda P. K., Pang L. H., Panigada M., Pansu N., Papadopoulos A., Parke R., Pasquier J., Pastene B., Patauner F., Pathmanathan M. D., Patricio P., Patrier J., Patterson L., Paul M., Paul C., Paulos J., Paxton W. A., Payen J. -F., Peake S. L., Peariasamy K., Jimenez M. P., Peek G. J., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrovic M., Petrov-Sanchez V., Pettersen F. O., Peytavin G., Pharand S., Piagnerelli M., Picard W., Picone O., Pierobon C., Piersma D., Pimentel C., Piquard V., Pires C., Pironneau I., Piroth L., Pitaloka A., Piubelli C., Pius R., Plantier L., Png H. S., Poissy J., Pokeerbux R., Poli S., Pollakis G., Ponscarme D., Porto D. B., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Prapa S., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Proenca L., Pudota S., Puechal O., Semedi B. P., Purcell G., Quesada L., Gonzalez V. Q., Quist-Paulsen E., Quraishi M., Qutishat F., Rabaud C., Rafael A., Rafiq M., Rahardjani M., Rahimi A. K., Rahman R. A., Haji Ab Rahman A. K., Rainieri F., Rajahram G. S., Ramakrishnan N., Ramalho J., Ramli A. A., Rammaert B., Ramos G. V., Ranjan R., Rapp C., Rasmin M., Ratsep I., Ravi T., Real A., Rebaudet S., Redl S., Reeve B., Reid L., Reikvam D. H., Reis R., Remy M., Ren H., Resseguier A. -S., Revest M., Rewa O., Reyes T., Reyes L. F., Ribeiro M. I., Richardson D., Richier L., Atikah Ahmad Ridzuan S. N., Rios A. L., Rishu A., Rispal P., Risso K., Rizer N., Robba C., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Roessler B., Roger P. -M., Rojek A., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salazar L., Sales G., Sallaberry S., Gandonniere C. S., Salvator H., Sanchez E., Sanchez O., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmiento I. C. E., Sarton B., Satyapriya S., Satyawati R., Saviciute E., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shadowitz E., Shahidan S. A., Shamsah M., Shankar A., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheenan J. R., Shi H., Shime N., Shimizu H., Shimizu K., Shum H. P., Mohammed N. S., Siang N. Y., Sibiude J., Siddiqui A., Sigfrid L., Sillaots P., Silva C., Silva R., Silva M. J., Lim Heng B. S., Sin W. C., Singh P., Singh B. C., Sitompul P. A., Sivam K., Skogen V., Smith S., Smood B., Smyth C., Smyth M., Snacken M., So D., Soh T. V., Solomon J., Solomon T., Somers E., Sommet A., Song R., Song M. J., Song T., Chia J. S., Sotto A., Soum E., Sousa M., Sousa A. C., Uva M. S., Souza-Dantas V., Sperry A., Spinuzza E., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Streinu-Cercel A., Stuart A., Stuart D., Su R., Subekti D., Suen G., Suen J. Y., Sukumar P., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Svistunov S. A., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Tagherset L., Taib S. M., Taleb S., Talsma J., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka H., Tanaka T., Taniguchi H., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tellier M. -C., Teoh S. K., Teotonio V., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Mohd Thabit A. A., Tham Z. D., Thangavelu S., Theron E., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thorpe M., Thanga Thurai S. R., Thwaites R. S., Tierney P., Tieroshyn V., Timashev P. S., Timsit J. -F., Tissot N., Toal F., Yang Toh J. Z., Toki M., Tonby K., Tonnii S. L., Torre M., Torres A., Torres-Zevallos H., Towers M., Trapani T., Tromeur C., Trontzas I., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turgeon A. F., Turmel J. -M., Turtle L. C. W., Tveita A., Twardowski P., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Vajdovics C., Val-Flores L., Valran A., Van de Velde S., van den Berge M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vidal J. E., Vieira C., Villanueva J. A., Villoldo A., Visseaux B., Vitiello C., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Walsh L., Wang C. -H., Webb S., Wei J., Wen T. P., Wesselius S., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams B., Williams V., Williams P. J., Wils E. -J., Wittman J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Xian G. E., Xian L. S., Kuan P. X., Xynogalas I., Binti Mohd Yakop S. R., Yamazaki M., Yarad E., Yazdanpanah Y., Liang Hing N. Y., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zahid M., Zahran M., Binti Zaidan N. Z., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes.
- Published
- 2023
29. Liver injury in hospitalized patients with COVID-19: An International observational cohort study
- Author
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A., Donohue C., Donohue S., Donohue Y., Doran P., Dorival C., D'Ortenzio E., Douglas J. J., Dournon N., Downer T., Downey J., Downing M., Drake T., Dryden M., Fonseca C. D., Dubee V., Dubos F., Ducancelle A., Duculan T., Dudman S., Duggal A., Dunand P., Dunning J., Duplaix M., Durham L., Dussol B., Duthoit J., Duval X., Dyrhol-Riise A. M., Ean S. C., Echeverria-Villalobos M., Eira C., Sanharawi M. E., Elapavaluru S., Elharrar B., Ellerbroek J., Eloy P., Elshazly T., Enderle I., Eng C. C., Engelmann I., Enouf V., Epaulard O., Escher M., Esperatti M., Esperou H., Santo C. E., Esposito-Farese M., Estevao J., Etienne M., Ettalhaoui N., Everding A. G., Evers M., Fabre I., Fabre M., Faheem A., Fairfield C. J., Faria P., Farooq A., Fateena H., Fatoni A. Z., Faure K., Favory R., Fayed M., Feeney L., Fernandes J., Fernandes M. A., Fernandes S., Ferrand F. -X., Devouge E. F., Ferrao J., Ferraz M., Ferreira B., Ferreira I., Ferreira S., Ferriere N., Ficko C., Figueiredo-Mello C., Fiorda J., Flament T., Flateau C., Fletcher T., Florence A. -M., Flynn D., Foley J., Fomin V., Fonseca T., Forsyth S., Foti G., Fourn E., Fowler R. A., Fraher M., Franch-Llasat D., Fraser C., Fraser J. F., Freire M. V., Ribeiro A. F., French C., Friedrich C., Fritz R., Fry S., Fuentes N., Fukuda M., Argin G., Gaborieau V., Gaci R., Gagnard J. -C., Gagneux-Brunon A., Gaiao S., Skeie L. G., Gallagher P., Gamble C., Gani Y., Garan A., Garcia R., Garcia-Gallo E., Garot D., Gar V., Gault N., Gavin A., Gavrylov A., Gaymard A., Gebauer J., Geraud E., Morlaes L. G., Germano N., Ghosn J., Giani M., Giaquinto C., Gigante T., Gilg M., Giordano G., Girvan M., Gissot V., Glikman D., Glybochko P., Gnall E., Goehringer F., Goepel S., Goffard J. -C., Goh J. Y., Golob J., Gomez-Junyent J., Gominet M., Gonzalez A., Gordon P., Gorenne I., Goubert L., Goujard C., Goulenok T., Grable M., Grandin E. W., Granier P., Grasselli G., Green C. A., Greene C., Greenhalf W., Greffe S., Griffee M., Griffiths F., Groenendijk A., Lordemann A. G., Gruner H., Gu Y., Guedj J., Guego M., Guellec D., Guerreiro D., Guery R., Guillaumot A., Guilleminault L., de Castro M. G., Guimard T., Haalboom M., Haber D., Hachemi A., Hadri N., Hall A., Hall M., Halpin S., Hamer A., Hamidfar R., Hammond T., Han L. Y., Haniffa R., Hao K. W., Hardwick H., Harrison E. M., Harrison J., Hartman A., Hayes A., Hays L., Heerman J., Heggelund L., Hendry R., Hennessy M., Henriquez A., Hentzien M., Hernandez D., Hershey A., Hesstvedt L., Higgins D., Higgins E., Higgins R., Hinton S., Hiraiwa H., Hitoto H., Ho A., Ho Y. B., Hoctin A., Hoffmann I., Hoh W. H., Hoiting O., Holter J. C., Horby P., Horcajada J. P., Hoshino K., Houas I., Hough C. L., Houltham S., Hsu J. M. -Y., Hulot J. -S., Huo S., Hurd A., Hussain I., Ijaz S., Ikram A., Illes H. -G., Imbert P., Sikander R. I., Inacio H., Ing Y. S., Iosifidis E., Ippolito M., Irawany V., Isgett S., Isidoro T., Ismail N., Isnard M., Ivulich D., Jaafar D., Jaafoura S., Jabot J., Jackson C., Jamieson N., Jaquet P., Jassat W., Jaud-Fischer C., Jaureguiberry S., Jego F., Jelani A. M., Jenum S., Jimbo-Sotomayor R., Joe O. Y., Jorge Garcia R. N., Joseph C., Joseph M., Jourdain M., Jung A., Juzar D., Kafif O., Kaguelidou F., Kaisbain N., Kaleesvran T., Kali S., Kamaluddin M. A. A., Kamaruddin Z. A. C., Kamarudin N., Kandel C., Kang K. Y., Karpayah P., Kasugai D., Kataria A., Katz K., Kay C., Kayyali L., Keane H., Keating S., Kelly A., Kelly C., Kelly N., Kelly S., Kelsey M., Kennon K., Kernan M., Kerroumi Y., Keshav S., Khalid I., Khalil A., Khan C., Khan I., Khanal S., Kho M. E., Khoo D., Khoo R., Khoo S., Kiat K. H., Kida Y., Kiiza P., Granerud B. K., Kim J. B., Kimmoun A., King A., Kitamura N., Klenerman P., Klont R., Bekken G. K., Knight S. R., Kobbe R., Kosgei C., Kpangon A., Krawczyk K., Krishnan S., Krishnan V., Kruglova O., Kumar D., Kumar G., Vecham P. K., Kurtzman E., Kutsogiannis D., Kutsyna G., Lachatre M., Lacoste M., Laffey J. G., Lafhej N., Lagrange M., Laine F., Lairez O., Lambert M., Langelot-Richard M., Langlois V., Lantang E. Y., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence T., Le M., Bihan C. L., Bris C. L., Falher G. L., Fevre L. L., Hingrat Q. L., Marechal M. L., Mestre S. L., Moal G. L., Moing V. L., Nagard H. L., Turnier P. L., Lee B. H., Lee H. G., Lee J., Lee S. H., Lee T. C., Lee Y. L., Leeming G., Lefebvre B., Lefebvre L., LeGac S., Lelievre J. -D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lene H. S., Lennon J., Leone M., Lepiller Q., Lescure F. -X., Lesens O., Lesouhaitier M., Lester-Grant A., Letrou S., Levy B., Levy Y., Levy-Marchal C., Lewandowska K., L'Her E., Bassi G. L., Liegeon G., Lim K. C., Lim W. S., Lima C., Lina B., Lina L., Lind A., Lingas G., Lion-Daolio S., Lissauer S., Livrozet M., Lizotte P., Lolong N., Loon L. C., Lopes D., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Low L. L., Lowik M., Loy J. S., Lucet J. C., Luna C. M., Luong L., Luque N., Luton D., Lwin N., Lyons R., Maasikas O., Mabiala O., Machado M., Machado S., Macheda G., Madiha H., Mahieu R., Mahy S., Maia A. R., Maier L. S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Malvy D., Manda V., Mandelbrot L., Manetta F., Mankikian J., Manning E., Manuel A., Malaque C. M. S., Marino F., Markowicz S., Eid C. M., Marsh L., Marshall J., Martelli C. T., Martin D. -A., Martin E., Martin-Blondel G., Martin-Loeches I., Martinot M., Martin-Quiros A., Martins A., Martins N., Rego C. M., Martucci G., Martynenko O., Marwali E. M., Marzukie M., Maslove D., Nor B. M., Matan M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Mazzoni T., Sweeney L. M., McArthur C., McCarthy A., McCloskey C., McDermott S., McDonald S. E., McGeer A., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Mehkri O., Melo L., Mendes J. J., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miranda-Maldonado H., Misnan N. A., Mohamed N. N. E., Mohamed T. J., Moin A., Molinos E., Molloy B., Monahan S., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S., Moore S. C., Cely L. M., Moro L., Morton B., Motos A., Mouquet H., Perrot C. M., Moyet J., Mudara C., Muh N. Y., Muhamad D., Mullaert J., Muller F., Muller K. E., Munblit D., Murphy A., Murphy L., Murray P., Murris M., Murthy S., Musaab H., Muyandy G., Nagrebetsky A., Narasimhan M., Nazerali-Maitland A., Neant N., Neb H., Nekliudov N., Neto R., Neumann E., Nghi A., Nguyen D., Leathlobhair N. N., Nichol A., Nitayavardhana P., Nonas S., Noordin N. A. M., Noret M., Norharizam N. F. I., Norman L., Notari A., Noursadeghi M., Nowinski A., Nseir S., Nunez J. I., Nyamankolly E., Brien F. O., Callaghan A. O., O'Callaghan A., Occhipinti G., O'Connor D., O'Donnell M., Ogston T., Oliveira J., Oliveira L., Olliaro P. L., O'Neil C., Ong D. S. Y., Ong J. Y., Oosthuyzen W., Openshaw P., Orozco-Chamorro C. M., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Othman S. Z., Ouamara N., Ouissa R., Oziol E., Pagadoy M., Pages J., Mas A. P., Palmarini S., Panarello G., Panda P. K., Pang L. H., Panigada M., Pansu N., Papadopoulos A., Parke R., Pasquier J., Pastene B., Dass Pathmanathan M., Patrao L., Patricio P., Patrier J., Patterson L., Paul C., Paul M., Paulos J., Paxton W. A., Payen J. -F., Peariasamy K., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrovic M., Petrov-Sanchez V., Pettersen F. O., Peytavin G., Pharand S., Piagnerelli M., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Piquard V., Pires C., Pironneau I., Piroth L., Pius R., Plantier L., Png H. S., Poissy J., Pokeerbux R., Poli S., Pollakis G., Ponscarme D., Porto D. B., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Pritchard M. G., Proenca L., Puechal O., Semedi B. P., Purcell G., Quesada L., Quist-Paulsen E., Quraishi M., Qutishat F. -F., Rabaud C., Rafael A., Rafiq M., Rahman A. K. H. A., Rahman R. A., Rainieri F., Rajahram G. S., Ramakrishnan N., Ramalho J., Ramli A. A., Rammaert B., Ramos G. V., Rana A., Ranjan R., Rapp C., Rasmin M., Ratsep I., Rau C., Ravi T., Rebaudet S., Redl S., Reeve B., Reid L., Reikvam D. H., Reis R., Remppis J., Remy M., Ren H., Renk H., Resseguier A. -S., Revest M., Rewa O., Reyes L. F., Reyes T., Ribeiro M. I., Richardson D., Richier L., Ridzuan S. N. A. A., Rios A. L., Rishu A., Rispal P., Risso K., Nunez M. A. R., Rizer N., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Roessler B., Roger P. -M., Roilides E., Rojek A., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salazar L., Sales G., Sallaberry S., Gandonniere C. S., Salvator H., Sanchez O., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Banheiro B. S., Sarmiento I. C. E., Sarton B., Satyapriya S., Satyawati R., Saviciute E., Savvidou P., Saw Y. T., Schermer T., Scherpereel A., Schneider M., Schwameis M., Scott J. T., Scott-Brown J., Sedillot N., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Shadowitz E., Shahidan S. A., Shamsah M., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheenan J. R., Shi H., Shimizu H., Shimizu K., Shrapnel S., Mohammed N. S., Siang N. Y., Sibiude J., Sigfrid L., Sillaots P., Silva M. J., Silva R., Heng B. S. L., Singh B. C., Sitompul P. A., Sivam K., Smith S., Smood B., Smyth M., Snacken M., Soh T. V., Solomon J., Solomon T., Somers E., Sommet A., Song M. J., Song T., Chia J. S., Sonntagbauer M., Soom A. M., Sotto A., Soum E., Sousa A. C., Sousa M., Uva M. S., Souza-Dantas V., Sperry A., Spinuzza E., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stone A., Streinu-Cercel A., Stuart A., Stuart D., Su R., Suen G., Suen J. Y., Sukumar P., Sultana A., Summers C., Suppiah D., Svistunov A., Syahrin S., Sztajnbok J., Szuldrzynski K., Tabrizi S., Tagherset L., Taib S. M., Taleb S., Talsma J., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka T., Tardivon C., Tattevin P., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tellier M. -C., Teoh S. K., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Thabit A. A. M., Tham Z. D., Thangavelu S., Theron E., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thurai S. R. T., Thwaites R. S., Tieroshyn V., Timashev P. S., Timsit J. -F., Tissot N., Toal F., Toh J. Z. Y., Tonby K., Tonnii S. L., Torre M., Torres A., Santos-Olmo R. M. T., Torres-Zevallos H., Trapani T., Trioux T., Tromeur C., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turmel J. -M., Turtle L. C. W., Tveita A., Uchiyama M., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Val-Flores L., Valran A., Van de Velde S., van den Berge M., Van der Feltz M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vickers J., Vidal J. E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Visseaux B., Vitiello C., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Wainstein M., Walsh L., Wang C. -H., Webb S., Wei J., Wen T. P., Wesselius S., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Willems S., Williams V., Wils E. -J., Wong C., Wong T. F., Wong X. C., Wong Y. S., Xian G. E., Xian L. S., Xuan K. P., Yakop S. R. B. M., Yamazaki M., Yazdanpanah Y., Hing N. Y. L., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., and Zucman D.
- Abstract
Background Using a large dataset, we evaluated prevalence and severity of alterations in liver enzymes in COVID-19 and association with patient-centred outcomes. Methods We included hospitalized patients with confirmed or suspected SARS-CoV-2 infection from the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) database. Key exposure was baseline liver enzymes (AST, ALT, bilirubin). Patients were assigned Liver Injury Classification score based on 3 components of enzymes at admission: Normal; Stage I) Liver injury: any component between 1-3x upper limit of normal (ULN); Stage II) Severe liver injury: any component ≥3x ULN. Outcomes were hospital mortality, utilization of selected resources, complications, and durations of hospital and ICU stay. Analyses used logistic regression with associations expressed as adjusted odds ratios (OR) with 95% confidence intervals (CI). Results Of 17,531 included patients, 46.2% (8099) and 8.2% (1430) of patients had stage 1 and 2 liver injury respectively. Compared to normal, stages 1 and 2 were associated with higher odds of mortality (OR 1.53 [1.37-1.71]; OR 2.50 [2.10-2.96]), ICU admission (OR 1.63 [1.48-1.79]; OR 1.90 [1.62-2.23]), and invasive mechanical ventilation (OR 1.43 [1.27-1.70]; OR 1.95 (1.55-2.45). Stages 1 and 2 were also associated with higher odds of developing sepsis (OR 1.38 [1.27-1.50]; OR 1.46 [1.25-1.70]), acute kidney injury (OR 1.13 [1.00-1.27]; OR 1.59 [1.32-1.91]), and acute respiratory distress syndrome (OR 1.38 [1.22-1.55]; OR 1.80 [1.49-2.17]). Conclusions Liver enzyme abnormalities are common among COVID-19 patients and associated with worse outcomes.
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- 2023
30. Macrophage Migration Inhibitory Factor (MIF)
- Author
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Williams, Andrew, primary, Donnelly, C., additional, and Baugh, J.A., additional
- Published
- 2021
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31. The role of platelet‐rich plasma in androgenetic alopecia: A systematic review.
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Donnelly, C., Minty, I., Dsouza, A., Wong, Y. Y., Mukhopadhyay, I., Nagarajan, V., Rupra, R., Charles, W. N., and Khajuria, A.
- Subjects
- *
PLATELET-rich plasma , *BALDNESS - Abstract
Background: Androgenetic alopecia (AGA), also referred to as male or female pattern hair loss, is the commonest cause of chronic hair loss and affects up to 80% of men by the age of 70. Despite a high prevalence, there are few approved therapies, which show minimal efficacy. Objectives: This systematic review aims to evaluate the efficacy of platelet‐rich plasma (PrP) in the treatment of AGA in male patients. Methods: MEDLINE, EMBASE, Cochrane (CENTRAL), CINAHL, clinicaltrials.gov, Google Scholar and the Science Citation Index database were searched to identify eligible studies. All randomized controlled trials (RCTs) and prospective cohort studies related to PrP use in AGA were included. Primary outcomes included changes in hair density and hair count. Methodological quality was assessed using bias assessment tools. Results: Eight RCTs and one cohort study were included in the review with a total of 291 participants. Six studies reported a statistically significant increase in hair density in the PrP group versus the control. Five studies reported a statistically significant increase in hair count with PrP. Seven studies showed moderate risk and two showed low risk of bias. Conclusion: In a methodologically robust review on the effectiveness of PrP on male AGA, PrP demonstrated some potential to be used therapeutically. However, the low quality of evidence, moderate risk of bias, and high heterogeneity of included studies limit inferences and call for more robust designs to investigate this further. [ABSTRACT FROM AUTHOR]
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- 2024
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32. A quality improvement project on operative records
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Soh, V, primary, Mowlood, C, additional, Yuen Eow, S, additional, Donnelly, C, additional, Dow, E, additional, Reid, J, additional, Elbaroni, W, additional, and Healy, D, additional
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- 2023
- Full Text
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33. Design and Implementation of a National SARS-CoV-2 Monitoring Program in England: REACT-1 Study
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Elliott, P, Whitaker, M, Tang, D, Eales, O, Steyn, N, Bodinier, B, Wang, H, Elliott, J, Atchison, C, Ashby, D, Barclay, W, Taylor, G, Darzi, A, Cooke, G, Ward, H, Donnelly, C, Riley, S, and Chadeau-Hyam, M
- Subjects
Public Health, Environmental and Occupational Health - Abstract
Data System. The REal-time Assessment of Community Transmission-1 (REACT-1) Study was funded by the Department of Health and Social Care in England to provide reliable and timely estimates of prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection over time, by person and place. Data Collection/Processing. The study team (researchers from Imperial College London and its logistics partner Ipsos) wrote to named individuals aged 5 years and older in random cross-sections of the population of England, using the National Health Service list of patients registered with a general practitioner (near-universal coverage) as a sampling frame. We collected data over 2 to 3 weeks approximately every month across 19 rounds of data collection from May 1, 2020, to March 31, 2022. Data Analysis/Dissemination. We have disseminated the data and study materials widely via the study Web site, preprints, publications in peer-reviewed journals, and the media. We make available data tabulations, suitably anonymized to protect participant confidentiality, on request to the study’s data access committee. Public Health Implications. The study provided inter alia real-time data on SARS-CoV-2 prevalence over time, by area, and by sociodemographic variables; estimates of vaccine effectiveness; and symptom profiles, and detected emergence of new variants based on viral genome sequencing. (Am J Public Health. 2023;113(5):545–554. https://doi.org/10.2105/AJPH.2023.307230 )
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- 2023
34. Simulation of nitrate reduction in groundwater – An upscaling approach from small catchments to the Baltic Sea basin
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Hansen, A.L., Donnelly, C., Refsgaard, J.C., and Karlsson, I.B.
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- 2018
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35. Business location decisions and the management of transport demand in Northern Ireland
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Donnelly, C. M. T.
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338.604209416 - Published
- 2008
36. Seroprevalence of IgG Antibodies to SARS-Coronavirus in Asymptomatic or Subclinical Population Groups
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Leung, G. M., Lim, W. W., Ghani, A. C., Donnelly, C. A., Fraser, C., Riley, S., Ferguson, N. M., Anderson, R. M., and Hedley, A. J.
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- 2006
37. Epidemiological Analysis of Data for Scrapie in Great Britain
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Hagenaars, T. J., Donnelly, C. A., and Ferguson, N. M.
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- 2006
38. Spatial Association of Mycobacterium bovis Infection in Cattle and Badgers Meles meles
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Woodroffe, R., Donnelly, C. A., Johnston, W. T., Bourne, F. J., Cheeseman, C. L., Clifton-Hadley, R. S., Cox, D. R., Gettinby, G., Hewinson, R. G., Le Fevre, A. M., McInerney, J. P., and Morrison, W. I.
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- 2005
39. Product options for enhanced retirement income
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Donnelly, C. and Young, J.
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- 2017
40. 781 An Overview of Operative Notes in the Vascular Surgical Unit in Northern Ireland
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Soh, V, primary, Healy, D, additional, Mowlood, C, additional, Eow, S Y, additional, Donnelly, C, additional, and Dow, E, additional
- Published
- 2023
- Full Text
- View/download PDF
41. Memo from C. H. Donnelly to Secretariat, Joint Committee on New Weapons and Equipment, January 8, 1944
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Donnelly, C. H., author and Donnelly, C. H., author
42. Dynamics of a Scrapie Outbreak in a Flock of Romanov Sheep: Estimation of Transmission Parameters
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Hagenaars, T. J., Donnelly, C. A., Ferguson, N. M., and Anderson, R. M.
- Published
- 2003
43. Geographical variability in survival of European children with central nervous system tumours
- Author
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Hackl, M., Zielonke, N., Oberaigner, W., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Storm, H., Engholm, G., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Faivre, J., Bossard, N., Uhry, Z., Colonna, M., Clavel, J., Lacour, B., Desandes, E., Brenner, H., Kaatsch, P., Katalinic, A., Garami, M., Jakab, Z., Comber, H., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Sutera Sardo, A., Mancuso, P., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Zucchetto, A., De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Filiberti, R.A., Marani, E., Ricci, P., Pascucci, C., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Usala, M., Vitale, F., Ravazzolo, B., Michiara, M., Merletti, F., Maule, M., Tumino, R., Mangone, L., Di Felice, E., Falcini, F., Iannelli, A., Sechi, O., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Maspero, S., Fanetti, A.C., Candela, P., Scuderi, T., Stracci, F., Bianconi, F., Tagliabue, G., Contiero, P., Rugge, M., Guzzinati, S., Pildava, S., Smailyte, G., Calleja, N., Agius, D., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Bębenek, M., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Castro, C., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Errezola, M., Bidaurrazaga, J., Vicente Raneda, M., Díaz García, J.M., Marcos-Navarro, A.I., Marcos-Gragera, R., Izquierdo Font, A., Sanchez, M.J., Chang, D.Y.L., Navarro, C., Chirlaque, M.D., Moreno-Iribas, C., Ardanaz, E., Peris-Bonet, R., Pardo Romaguera, E., Galceran, J., Carulla, M., Lambe, M., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Aarts, M., Otter, R., Coleman, M., Allemani, C., Rachet, B., Verne, J., Stiller, C., Gavin, A., Donnelly, C., Brewster, D.H., Sánchez, M.-J., and Rutkowski, S.
- Published
- 2017
- Full Text
- View/download PDF
44. Survival of 86,690 patients with thyroid cancer: A population-based study in 29 European countries from EUROCARE-5
- Author
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Hackl, M., Zielonke, N., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Dušek, L., Zvolský, M., Storm, H., Engholm, G., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Velten, M., Guizard, A.V., Faivre, J., Woronoff, A.S., Tretarre, B., Bossard, N., Uhry, Z., Colonna, M., Molinié, F., Bara, S., Schvartz, C., Lapôtre-Ledoux, B., Grosclaude, P., Stabenow, R., Luttmann, S., Eberle, A., Brenner, H., Nennecke, A., Engel, J., Schubert-Fritschle, G., Heidrich, J., Holleczek, B., Katalinic, A., Jónasson, J.G., Tryggvadóttir, L., Comber, H., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Sutera Sardo, A., Mazzei, A., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Zucchetto, A., De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Filiberti, R.A., Vercelli, M., Ricci, P., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Usala, M., Vitale, F., Ravazzolo, B., Michiara, M., Tumino, R., Mangone, L., Vicentini, M., Falcini, F., Iannelli, A., Sechi, O., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Maspero, S., Fanetti, A.C., Zanetti, R., Rosso, S., Candela, P., Scuderi, T., Stracci, F., Rocca, A., Tagliabue, G., Contiero, P., Rugge, M., Tognazzo, S., Pildava, S., Smailyte, G., Calleja, N., Agius, D., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Bębenek, M., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Castro, C., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Errezola, M., Bidaurrazaga, J., Díaz García, J.M., Marcos-Navarro, A.I., Marcos-Gragera, R., Izquierdo Font, A., Sanchez, M.J., Molina, E., Navarro, C., Chirlaque, M.D., Moreno-Iribas, C., Ardanaz, E., Galceran, J., Carulla, M., Lambe, M., Khan, S., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Ho, V., Otter, R., Coleman, M., Allemani, C., Rachet, B., Rashbass, J., Broggio, J., Verne, J., Gavin, A., Donnelly, C., Brewster, D.H., Huws, D.W., White, C., Dal Maso, L., Pacini, F., van Dijk, B.A.C., Larrañaga, N., Rubió-Casadevall, J., Kowalska, A., and Virdone, S.
- Published
- 2017
- Full Text
- View/download PDF
45. Synaptic weighting in single flux quantum neuromorphic computing
- Author
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Schneider, M. L., Donnelly, C. A., Haygood, I. W., Wynn, A., Russek, S. E., Castellanos-Beltran, M. A., Dresselhaus, P. D., Hopkins, P. F., Pufall, M. R., and Rippard, W. H.
- Published
- 2020
- Full Text
- View/download PDF
46. Persistence Patterns of Scrapie in a Sheep Flock
- Author
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Hagenaars, T. J., Ferguson, N. M., Donnelly, C. A., and Anderson, R. M.
- Published
- 2001
47. A Discussion on the Evolution and Application of Quantitative Risk Informed Dam Safety Decision Making
- Author
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Donnelly, C. Richard, primary and Acharya, A. M., additional
- Published
- 2019
- Full Text
- View/download PDF
48. Spatial Perturbation Caused by a Badger (Meles meles) Culling Operation: Implications for the Function of Territoriality and the Control of Bovine Tuberculosis (Mycobacterium bovis)
- Author
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Tuyttens, F. A. M., Delahay, R. J., MacDonald, D. W., Cheeseman, C. L., Long, B., and Donnelly, C. A.
- Published
- 2000
49. Factors Affecting the Presence of the Cool Temperate Rain Forest Tree Myrtle Beech (Nothofagus cunninghamii) in Southern Australia: Integrating Climatic, Terrain and Disturbance Predictors of Distribution Patterns
- Author
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Lindenmayer, D. B., Mackey, B. G., Cunningham, R. B., Donnelly, C. F., Mullen, I. C., McCarthy, M. A., and Gill, A. M.
- Published
- 2000
50. Feed-Borne Transmission and Case Clustering of BSE
- Author
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Hagenaars, T. J., Ferguson, N. M., Donnelly, C. A., Ghani, A. C., and Anderson, R. M.
- Published
- 2000
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