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Background Feline calicivirus (FCV) is a common and highly prevalent pathogen causing upper respiratory diseases in kittens and felines in recent years. Due to the substantial genetic variability of the viral genes, existing vaccines cannot provide complete protection. Therefore, research on FCV antiviral drugs has received much attention. Results In this study, we found that copper chloride had dose-dependent antiviral effects on FCV in F81 cells. We also found that the combination of copper chloride and ribavirin had a synergistic protective effect against FCV in F81 cells. In contrast, the combination of copper chloride and horse anti-FCV immunoglobulin F (ab’)2 showed an antagonistic effect, likely because copper chloride has an effect on F (ab’)2 immunoglobulin; however, further research is needed to clarify this supposition. Conclusions In summary, we found that copper chloride had low cytotoxicity and significant antiviral effects on FCV in F81 cells, providing a new drug candidate for the prevention and treatment of FCV infection.

Feline calicivirus (FCV) is a highly contagious pathogen that causes acute upper respiratory infections and oral disease in cats, thus seriously endangering feline health. Recently, there have been outbreaks of particularly virulent variant strains of FCV, which can cause both acute symptoms and fatal systemic disease. The discovery of effective antiviral agents to treat FCV infection is, therefore, gradually assuming increased importance. In this study, we showed that both nitazoxanide and mizoribine had antiviral activity in F81 cells infected with different strains of FCV and also demonstrated a synergistic effect between the two drugs. Experiments in cats challenged with FCV showed that nitazoxanide significantly reduced the clinical symptoms of FCV infection, reduced viral load in the trachea and lungs, and reduced viral shedding. Our results showed that nitazoxanide and mizoribine could potentially be used as therapeutic agents to treat FCV infection., Highlights • Mizoribine had antiviral activity against FCV. • Nitazoxanide and mizoribine had synergistic anti-FCV effects. • Nitazoxanide alleviated clinical symptoms in FCV-infected kittens. • Nitazoxanide significantly reduced viral titers in lungs and trachea of kittens infected with FCV.

With the development of Micro-blogging and Wechat, updating and widely used mobile terminal technologies, as well as micro-philanthropy, "micro-era" has come. The widespread use of information technology in social life changes the way people communicate and the way of living dramatically, thus changing the ideology of the people, thereby affecting people's social life, especially for college students who are very sensitive to information technology. The core values of students are a very important part of the development of a healthy personality and the development direction of socialism with Chinese characteristics. The arrival of "micro-era" has brought new opportunities and challenges to the development of college students'core values. Universities must adapt to the new situation and create a harmonious and healthy "micro-environment" to promote the "micro culture."

One of the core mission of universities is to cultivate innovative talents , and to achieve this goal, we must innovative training model . Innovative Talent Training Mode agricultural colleges and universities is a modern economy , a necessary requirement for agricultural development , the paper explore the meaning and significance of constructing personalized innovative talent training mode , discusses the agricultural colleges and universities to build innovative training model of the basic ways . Keywordspersonality ; innovation ; agricultural colleges and universities ; personnel training mode

Teaching management information is an important way to improve the efficiency of the school, is the core of the modern university development work. With the establishment of the rapid development of computer network technology and the campus network, teaching management information already in practice and will further play a huge role and performance. In this paper, the crux of the necessity of teaching management information, the status of university teaching management and information technology issues, measures tripartite teaching management information construction in the face of college teaching management information necessary to conduct a detailed explanation and discussion.

The problems of the vacuum preloading method in treating recently-filled hydraulic fill are analyzed. The improved vacuum preloading method is put forward for the treatment of recently-fill hydraulic fills; the model tests of the key technology of the improved vacuum preloading method have been performed. The superiority of the method is studied. The study result shows that: the improved vacuum preloading method can overcome the disadvantages of the vacuum preloading method in dealing with recently-fill hydraulic fill, can be constructed on the surface of the mud fill directly, and can save processing time more than 6 months and about 40% of the pre-processing costs.