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A multi-functional graphene-based flame retardant (MZP-GO) has been successfully developed via a three-step chemical modification.

Limited durability and complex materials restrict the application of superhydrophobic fabrics in daily life. In this work, gellable fluorinated block copolymer poly(dodecafluoroheptyl methacrylate)

SUMMARY The Salton Sea Geothermal Field (SSGF) is one of the most seismically active and geothermally productive fields in California. Here we present a detailed analysis of short-term seismicity change in SSGF from 2008 to 2013 during and right following large distant earthquakes, as well as long-term seismicity change due to geothermal productions. We first apply a GPU-based waveform matched-filter technique (WMFT) to the continuous data recorded by the Calenergy Borehole (EN) Network and detect more than 70 000 new micro-earthquakes than listed in the standard Southern California Seismic Network catalogue. We then analyse the seismicity rate changes in the SSGF associated with transient stress fluctuations triggered by regional and large teleseismic earthquakes from 1999 to 2019. We find triggered seismicity in the SSGF following seven regional M > 5.5 earthquakes. In comparison, most teleseismic earthquakes with M > 8.0 did not trigger significant seismicity rate change in the SSGF, likely indicating a frequency dependence in remote dynamic triggering. We further characterize the correlation between the long-term seismicity rate and geothermal production rates, and the temporal and spatial distribution of Guttenberg–Richter b-values inside and outside the SSGF with the newly detected catalogue. The long-term seismicity shows that events with M > 1.5 are likely correlated with net production rates, while smaller events do not show any correlation. The b-values inside the SSGF are higher than those outside the SSGF, and the locations of dynamically triggered events are close to locations with high b-values.

The water level change in the Great Lake region can modulate stresses in the nearby fault system and potentially induce earthquakes. We perform a systematic analysis of local seismicity around southern Lake Erie during 2013–2020 to investigate the relation between seismicity and lake water level change. We obtain a newly detected catalog of tectonic earthquakes, which reveals 20–40 M > 0 earthquakes/yr before 2019. The peak seismicity rate in 2019 is dominated by active aftershocks following the 2019 ML 4.0 Ohio earthquake. The clustering analysis reveals both clusters with multiple events and stand-alone events that might represent isolated zones of crustal weakness in this region. The absolute location analysis identifies a group of earthquakes around the epicenter of the 1986 M 5 earthquake, which might be linked to the nearby injection activities. To evaluate the potential interaction with changing water loading of Lake Erie, we then model the coulomb stress change (ΔCSC) caused by elastic lake-water loading and find that ΔCSC strongly depends on effective friction coefficient (μ′). Considering the geometry of the receiver fault, higher lake water level results in positive ΔCSC and would promote failure when μ′≤0.3, and leads to negative ΔCSC and would discourage rupture when μ′>0.3. Further analysis indicates a lack of temporal correlation between long-term seismicity and water level variations before the 2019 Ohio sequence, suggesting that water level fluctuations do not modulate long-term seismicity. However, we cannot fully rule out the impact of increasing water level on reactivating the fault that hosted the 2019 Ohio earthquake sequence because of the uncertainty of μ′. Our results highlight the necessity of denser and closer monitoring of lake seismicity to further investigate the impact of changing water loading on reactivating shallow faults in this region.

Background: Alzheimer’s disease (AD) is a fatal neurodegenerative disease, the etiology of which is unclear. Previous studies have suggested that some viruses are neurotropic and associated with AD. Objective: By using bioinformatics analysis, we investigated the potential association between viral infection and AD. Methods: A total of 5,066 differentially expressed genes (DEGs) in the temporal cortex between AD and control samples were identified. These DEGs were then examined via weighted gene co-expression network analysis (WGCNA) and clustered into modules of genes with similar expression patterns. Of identified modules, module turquoise had the highest correlation with AD. The module turquoise was further characterized using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment analysis. Results: Our results showed that the KEGG pathways of the module turquoise were mainly associated with viral infection signaling, specifically Herpes simplex virus, Human papillomavirus, and Epstein-Barr virus infections. A total of 126 genes were enriched in viral infection signaling pathways. In addition, based on values of module membership and gene significance, a total of 508 genes within the module were selected for further analysis. By intersecting these 508 genes with those 126 genes enriched in viral infection pathways, we identified 4 hub genes that were associated with both viral infection and AD: TLR2, COL1A2, NOTCH3, and ZNF132. Conclusion: Through bioinformatics analysis, we demonstrated a potential link between viral infection and AD. These findings may provide a platform to further our understanding of AD pathogenesis.

A rather simple and feasible strategy to construct MOF porous liquids with low viscosities for CO2 capture.

SRPILs is initially proposed to upgrade the liquids adsorption technology. Tailoring the phase state of SRPILs depending on requirements can simultaneously alleviate liquids states and solids states limitations, maximizing PLs applications.

Graphene, with high strength and ultra-high specific surface area, is an excellent filler to improve the mechanical properties of epoxy resin. However, due to the strong interface interaction betwe...

Inflammation resolution plays a significant role in attenuating bone injury aggravated by acute inflammation and maintaining bone homeostasis. Maresin 1 (MaR1), a specialized pro-resolving mediators (SPMs), is biosynthesised in macrophages (Mφs) that regulates acute inflammation. Strategies to accelerate the resolution of inflammation in bone repair include not only promoting vanish of acute inflammation, also improving osteogenic microenvironment. Here, previously prepared difunctional demineralized bone matrix (DBM) scaffold was used to study thoroughly the "cross-talk" between Mφs lipid metabolism and mesenchymal stem cells (MSCs) behaviors in vitro. The pro-resolving mechanism in Mφs treated with MaR1 was elaborated. Furthermore, the biological behaviors of MSCs in co-culture system were evaluated. The results indicated that MaR1 had an enhanced capability and performance in peroxisome proliferator-activated receptor-γ (PPAR-γ) activation, M2-type Mφs polarization, and lipid droplets (LDs) biogenesis in Mφs in vitro. The nuclear receptor PPAR-γ enhanced the anti-inflammatory proteins expression and the polarization of Mφs toward M2 subtype, thereby favoring the proliferation, migration, and osteogenesis of MSCs. Overall, the results verified that MaR1 facilitated MSCs behaviors by regulating PPAR-γ-mediated inflammatory response, which implied that PPAR-γ exhibited a significant role in the dialogue between MSCs behaviors and Mφs lipid metabolism.

The dialogue between host macrophages (Mφs) and endogenous mesenchymal stem cells (MSCs) promotes M2 Mφs polarization to resolve early-stage inflammation, thereby effectively guiding in situ bone regeneration. Once inflammation is unresolved/incontrollable, it will induce the impediment of MSCs homing at bone defect site, implying the seasonable resolution of inflammation in balancing bone homeostasis. Repeatedly, evidence elucidated that specialized pro-resolving mediators (SPMs) could conduce to proper resolve inflammation and promote the repairing of bone defect. A difunctional demineralized bone matrix (DBM) scaffold co-modified by maresin 1 (MaR1) and aptamer 19S (Apt19S) was fabricated to facilitate the osteogenesis of MSCs. To confirm the osteogenesis and immunomodulatory role of the difunctional DBM scaffold, the proliferation, recruitment, and osteogenic differentiation of MSCs and the Mφs M2 subtype polarization were evaluated in vitro. Then, the DBM scaffolds were implanted into mice model with critical size calvarial defect to evaluate bone repair efficiency. Finally, the specific resolution mechanism in Mφs cultured on the difunctional DBM scaffold was further in-depth investigated. This difunctional DBM scaffold exhibited an enhanced function on the recruitment, proliferation, migration, osteogenesis of MSCs and the resolution of inflammation, finally improved bone-scaffold integration. At the same time, MaR1 modified on the difunctional DBM scaffold increased the biosynthesis of 12-lipoxygenase (12-LOX) and 12S-hydroxy-eicosatetraenoic acid (12S-HETE), and also directly stimulated lipid droplets (LDs) biogenesis in Mφs, which suggested that MaR1 regulated Mφ lipid metabolism at bone repair site. Findings based on this synergy strategy demonstrated that Mφ lipid metabolism was essential in bone homeostasis, which might provide a theoretical direction for the treatment-associated application of MaR1 in inflammatory bone disease.

Porous liquids (PLs), an emerging kind of liquid materials with permanent porosity, have attracted increasing attention in gas capture. However, directly turning metal–organic frameworks (MOFs) int...

MXenes, an emerging class of two-dimensional (2D) materials, have driven a tremendous amount of research due to their fascinating properties including excellent metallic conductivities, favorable mechanical stability and easily tailorable surface chemistry. However, the daunting drawbacks of MXene flake restacking and oxidation instability hinder their further applications. To this end, we proposed a universal approach to transform Ti3C2Tx MXenes into nanoscale ionic materials (NIMs) using an electronic interaction strategy, where the Ti3C2Tx MXenes were firstly modified using an organosilane (OS) with acidic moieties, before electrostatic grafting of an alkaline oligomer to form the resultant stable electron-balanced MXene NIMs. The as-prepared Ti3C2Tx MXene NIMs presented rather stable antioxidant ability even after standing for 570 days. Moreover, MXene NIMs exhibit macroscopic flow behaviors at room temperature, which greatly improve processability and show extensive potential in addressing the daunting restacking issue when blending Ti3C2Tx MXene flakes with other polymer matrixes. Furthermore, the generality of this strategy was demonstrated by using various classes of alkaline oligomer species. As a proof of concept, Ti3C2Tx MXene NIMs (e.g., MX-I-M2070) were incorporated into the Pebax-1657 matrix to prepare mixed matrix membranes (MMMs), where the CO2 selective separation was investigated using experimental and molecular simulation (MS) methods. More notably, the rich library of alkaline oligomer species provides more convenience for further structural optimization, thus opening up plentiful opportunities for advancing the development of MXene NIMs towards other task-specific applications, such as catalysis and photothermal conversion.

Polymer-tethered nanoparticles with different geometric shapes are very useful fillers of polymer nanocomposites. Herein, a universal approach for the fabrication of such nanoparticles with precisely controlled shape and composition is reported. By microphase separation of poly(3-(triethoxysilyl)propyl methacrylate)-block-polystyrene (PTEPM-b-PS) in the presence of oligomers, o-TEPM (oT) and/or o-S (oS), followed by cross-linking and dispersion in PS solvent, precisely tailored PS-grafted nanoparticles were prepared. These particles include those with varied shapes but identical PS shells, particles with varied core sizes but the same PS shell, and particles with fixed shapes but varied PS shells. These particles are ideal model nanofillers to study the dynamics and reinforced mechanism of polymer nanocomposites.

The performance of graphene aerogels (GAs) is based on the microstructure. However, GAs face a challenge of simultaneously controlling the size and alignment of pores strategically. Herein, we initially proposed a simple strategy to construct GAs with an adjustable structure based on the emulsion and ice dual template methods. Specifically, GAs with a honeycomb structure prepared by conventional freezing (CGAs) exhibited a high specific surface of 176 m

Despite many important industrial applications, epoxy resin (EP) suffers from high flammability and toxicity emission, extremely hampering their applications. To circumvent the problem, core-shell structured ZIF67@ZIF8 is successfully synthesized and further functionalized with phytic acid (PA) to obtain PA-ZIF67@ZIF8 hybrids. Then, it is used as an efficient flame retardant to reduce the fire risk of EP. The fire test results show a significant reduction in heat and smoke production. Compared with EP, incorporating 5.0 wt % PA-ZIF67@ZIF8 into EP, the peak heat release rate, total heat release, and peak carbon monoxide production are dramatically reduced by 42.2, 33.0, and 41.5%, respectively. Moreover, the EP/PA-ZIF67@ZIF8 composites achieve the UL-94 V-0 rating and the limiting oxygen index increases by 29.3%. These superior fire safety properties are mainly attributed to the excellent dispersion and the catalytic effect of metal oxide and phosphorus-containing compounds. This work provides an efficient strategy for preparing a promising ZIF-based flame retardant for enhancing flame retardancy and smoke toxicity suppression of EP.

Advanced oxidation processes are widely applied to removal of persistent toxic substances from wastewater by hydroxyl radicals (·OH), which is generated from hydrogen peroxide (H2O2) decomposition. However, their practical applications have been hampered by many strict conditions, such as iron sludge, rigid pH condition, large doses of hydrogen peroxide and Fe2+, etc. Herein, a magnetically recyclable Fe3O4@polydopamine (Fe3O4@PDA) core-shell nanocomposite was fabricated. As an excellent reducing agent, it can convert Fe3+ to Fe2+. Combined with the coordination of polydopamine and ferric ions, the production of iron sludge is inhibited. The minimum concentration of hydrogen peroxide (0.2 mmol/L and Fe2+ (0.18 mmol/L)) is 150-fold and 100-fold lower than that of previous reports, respectively. It also exhibits excellent degradation performance over a wide pH range from 3.0 to 9.0. Even after the tenth recycling, it still achieves over 99% degradation efficiency with the total organic carbon degradation rate of 80%, which is environmentally benign and has a large economic advantage. This discovery paves a way for extensive practical application of advanced oxidation processes, especially in environmental remediation.

Owing to the characteristics of mimicking human skin's function and transmitting sensory signals, electronic skin (e-skin), as an emerging and exciting research field, has inspired tremendous efforts in the biomedical field. However, it is frustrating that most e-skins are prone to bacterial infections, resulting a serious threat to human health. Therefore, the construction of e-skin with an integrated perceptual signal and antibacterial properties is highly desirable. Herein, the dynamic supramolecular hydrogel was prepared through a freezing/thawing method by cross-linking the conductive graphene (G), biocompatible polyvinyl alcohol (PVA), self-adhesive polydopamine (PDA), and in situ formation antibacterial silver nanoparticles (AgNPs). Having fabricated the hierarchical network structure, the PVA-G-PDA-AgNPs composite hydrogel with a tensile strength of 1.174 MPa and an elongation of 331% paves way for flexible e-skins. Notably, the PVA-G-PDA-AgNPs hydrogel exhibits outstanding antibacterial activity to typical pathogenic microbes (e.g., Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus), which effectively prevents bacterial infections that harm human health. With self-adhesiveness to various surfaces and excellent conductivity, the PVA-G-PDA-AgNPs composite hydrogel was used as strain sensors to detect a variety of macroscale and microscale human motions successfully. Meanwhile, the excellent rehealing property allows the hydrogel to recycle as a new sensor to detect large-scale human activities or tiny movement. Based on these remarkable features, the antibacterial, self-adhesive, recyclable, and tough conductive composite hydrogels possess the great promising application in biomedical materials.

The conductive road materials are of great help for the development of intelligent road system. The graphite with different volume contents (0%, 15%, 25%, 35%, 45%) was used to prepare conductive asphalt mixture. In order to enhance the electrical conductivity of graphite modified asphalt mixture, the metal electrode was imbedded into the graphite modified asphalt mixture. The influence of graphite content and electrode on electrical conductivity of graphite modified asphalt mixture was evaluated through electrical resistance sensor (Keithley 6510 data acquisition system). Results show that the electrical conductivity of the graphite modified asphalt mixture increases when the content of graphite rises. The addition of electrodes can effectively increase the electrical conductivity of graphite modified asphalt mixtures within proper content of graphite.

Torealize intelligent and personalized medicine, it is a huge challenge to develop a hydrogel dressing that can be used as a sensor to monitor human health in real-time while promoting wound healing. Herein, an injectable, self-healing, and conductive chitosan-based (CPT) hydrogel with pH responsiveness and intrinsic antibacterial properties was fabricated via a Schiff base linkage and a hydrogen bond. Due to the introduction of Schiff base bonds, the injectable CPT hydrogel exhibits various excellent properties, such as pH responsiveness to sol-gel transition, self-healing properties, and broad-spectrum antibacterial properties even without additional antibacterial agents. In vitro experiments verify the excellent biocompatibility of the as-prepared hydrogel. An in vivo experiment in a mouse full-thickness skin-wound model was performed to confirm the outstanding effect on wound healing. Meanwhile, as epidermal sensors, the conductive hydrogel that perceives various human activities in real-time could provide the real-time analysis of the patient's healthcare information. Based on these excellent properties, the CPT hydrogel, as a biological dressing with a sensing function, lays a solid foundation for the further realization of personalized medicine.

Nitrate and sulfate are crucial factors of eutrophication and black and odorous water in the surface water and thus have raised increasing environmental concerns. Constructed wetlands (CWs) are the last ecological barrier before effluent enters the natural water body. To explore the simultaneous removal of nitrate and sulfate, the CW microcosms of CW-Con (with quartz sand), CW-ZVI (quartz sand and zero-valent iron), CW-Mag (quartz sand and magnetite), CW-ZVI + Mag (quartz sand, ZVI and magnetite) groups were set up under the low (100 mg/L)/high (300 mg/L) chemical oxygen demand (COD) concentration. Under the high COD condition, CW-ZVI group showed the best performance in nitrate (97.1%) and sulfate (96.9%) removal. Under the low COD concentration, the removal content of nitrate and sulfate in CW-ZVI group was better than CW-Mag group. The reason for this result was that zero-valent iron (ZVI) could be the electron donor for nitrate and sulfate reduction. Meanwhile, ZVI promoted chemical denitrification under high COD concentration according to PCA analysis. In addition, the produced sulfides inhibited the relative abundance of denitrifying bacteria, resulting in the lowest nitrate removal rate in CW-Mag group with sufficient electron donors. This study provided an alternative method to enhance simultaneous sulfate and nitrate removal in CWs.

Nanoparticles have a lot of unique properties because of their unique surface and volume characters, and they have been successfully applied in various fields. The aggregation of the nanoparticles is an inevitable question. To extend the application of nanoparticles, solvent-free nanofluids or liquid-like nanoparticles with a core coated with flexible organic chains had been established by researchers at the beginning of the twenty-first century. Possessing unique properties and functionalities, solvent-free nanofluids can prevent the aggregation of nanoparticles. Besides, they could provide a new platform for common nanoparticles on functionalization and application. This article reviews the development and tendency of solvent-free nanofluids, including synthesis methods and promising applications of different kinds of solvent-free nanofluids. The approaches for synthesis of solvent-free nanofluids with different cores, corona, and canopy will be presented. Applications of these solvent-free nanofluids in a variety of areas comprising gas capture and separation, polymer modification and reinforcement, ionic electrolytes, luminescent materials, and decolorization are also discussed.

Study objective To provide a contemporary medicolegal analysis of claims brought against anesthesia providers in the United States related to neuraxial blocks for surgery and obstetrics. Design In this retrospective analysis, we analyzed closed claims data from the Controlled Risk Insurance Company (CRICO) Comparative Benchmarking System (CBS) database between 2007 and 2016. Setting Closed claims from inpatient and outpatient settings related to neuraxial anesthesia for surgical procedures and obstetrics. Patients Forty-five claims were identified for analysis. These patients underwent a variety of surgical procedures, included both children and adults, and with ages ranging from 6 to 82. Interventions Patients receiving neuraxial anesthesia (spinals, epidurals) for surgery or obstetrics. Measurements Data collected includes patient demographics, alleged injury type/severity, surgical specialty, likely contributors to the alleged damaging event, and case outcome. Some of the data were drawn directly from coded variables in the CRICO database, and some were gathered from narrative case summaries. Main results Settlement payments were made in 20% of claims. Reported adverse outcomes ranged from temporary minor to permanent major injuries. Most closed claims were classified as permanent minor injuries. The greatest number of claims involved residual weakness and radiculopathy resulting from epidurals. The largest contributing factor to these injuries was noted to be “Technical Knowledge/Performance” of the anesthesia provider followed by “Missing or Documentation Error.” Over half of the claims arose from obstetric patients (31%) and patients undergoing orthopedic surgery (27%). Conclusions Patients with pre-existing radiculopathy or comorbidities may warrant more thorough informed consent about the increased risk of injury. Additionally, prompt follow-up, monitoring, and documentation of post-operative symptoms, such as weakness or radiculopathy, are crucial for improving patient safety and satisfaction. More timely communication with the patient and the surgical team regarding residual neurologic symptoms is important for earlier diagnosis of injury.