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Abstract Wastewater-based epidemiology has been used in pathogen surveillance for microorganisms at the community level. This study was conducted to determine the occurrence and trends of infectious pathogens in sewage from Yongin city and the relationships between these pathogens and the incidence of infectious diseases in the community. From December 2022 to November 2023, we collected inflow water from six wastewater treatment plants in Yongin city twice a month. The analyzed microorganisms included 15 respiratory viruses, 7 pneumonia-causing bacteria, 19 acute diarrhea-causing pathogens, SARS-CoV-2, Zika virus, hepatitis A virus, poliovirus, Mpox, and measles. They were detected through real-time PCR and conventional PCR. The concentrations of 9 pathogens among them were additionally analyzed using quantitative real time PCR. The correlation was confirmed through statistical analysis with the rate of detection for pathogens reported by the Korea Disease Control and Prevention Agency. Influenza A virus, human adenovirus, and human rhinovirus were moderately correlated (rho values of 0.45 to 0.58). Campylobacter spp. and sapovirus were strong correlated (rho values of 0.62, 0.63). Enteropathogenic E. coli, human coronavirus, and norovirus GII were very strong correlated (rho values of 0.86 to 0.92). We were able to identify the prevalence of respiratory viral infections, pneumonia, and acute diarrhea-causing pathogens in the community through wastewater-based epidemiology data. This study will be helpful in establishing a system for future surveillance of infectious diseases present in sewage.

Whereas systolic blood pressure (SBP) continuously rises with age, diastolic blood pressure (DBP) gradually decreases after the age of 55 years. Therefore, hypertension in the elderly shows the pattern of isolated systolic hypertension. There is evidence on the benefits of controlling blood pressure (BP) in elderly patients with hypertension. The BP lowering effect has also been demonstrated in patients over 80 years of age with hypertension. The BP threshold for the initiation of antihypertensive drug treatment for older adults with hypertension is gradually decreasing. The antihypertensive treatment is recommended if, despite therapeutic lifestyle modifications, SBP ≥140 mmHg or DBP ≥90 mmHg in those aged 65-79 years old, and SBP ≥140-160 mmHg or DBP ≥90 mmHg in those aged ≥80 years old. Although there is no consensus on the target BP for older adults with hypertension, a target SBP of

In this study, a room-temperature ammonia gas sensor using a ZnO and reduced graphene oxide (rGO) composite is developed. The sensor fabrication involved the innovative application of reverse offset and electrostatic spray deposition (ESD) techniques to create a ZnO/rGO sensing platform. The structural and chemical characteristics of the resulting material were comprehensively analyzed using XRD, FT-IR, FESEM, EDS, and XPS, and rGO reduction was achieved via UV–ozone treatment. Electrical properties were assessed through I–V curves, demonstrating enhanced conductivity due to UV–ozone treatment and improved charge mobility from the formation of a ZnO–rGO heterojunction. Exposure to ammonia gas resulted in increased sensor responsiveness, with longer UV–ozone treatment durations yielding superior sensitivity. Furthermore, response and recovery times were measured, with the 10 min UV–ozone-treated sensor displaying optimal responsiveness. Performance evaluation revealed linear responsiveness to ammonia concentration with a high R2 value. The sensor also exhibited exceptional selectivity for ammonia compared to acetone and CO gases, making it a promising candidate for ammonia gas detection. This study shows the outstanding performance and potential applications of the ZnO/rGO-based ammonia gas sensor, promising significant contributions to the field of gas detection.

This paper reports a high-performance humidity sensor made using a novel cellulose nanofiber (CNF)–silver nanoparticle (AgNP) sensing material. The interdigital electrode pattern was printed via reverse-offset printing using Ag nano-ink, and the sensing layer on the printed interdigitated electrode (IDE) was formed by depositing the CNF-AgNP composite via inkjet printing. The structure and morphology of the CNF-AgNP layer are characterized using ultraviolet–visible spectroscopy, an X-ray diffractometer, field emission scanning electron microscopy, energy-dispersive X-ray analysis, and transmission electron microscopy. The humidity-sensing performance of the prepared sensors is evaluated by measuring the impedance changes under the relative humidity variation between 10 and 90% relative humidity. The CNF-AgNP sensor exhibited very sensitive and fast humidity-sensing responses compared to the CNF sensor. The electrode distance effect and the response and recovery times are investigated. The enhanced humidity-sensing performance is reflected in the increased conductivity of the Ag nanoparticles and the adsorption of free water molecules associated with the porous characteristics of the CNF layer. The CNF-AgNP composite enables the development of highly sensitive, fast-responding, reproducible, flexible, and inexpensive humidity sensors.

The performance, stability, and lifespan of lithium-ion batteries are influenced by variations in the flow of lithium ions with temperature. In electric vehicles, coolants are generally used to maintain the optimal temperature of the battery, leading to an increasing demand for temperature and humidity sensors that can prevent leakage and short circuits. In this study, humidity and temperature sensors were fabricated on a pouch film of a pouch-type battery. IDE electrodes were screen-printed on the pouch film and humidity- and temperature-sensing materials were printed using a dispenser process. Changes in the capacitance of the printed Ag-CNF film were used for humidity sensing, while changes in the resistance of the printed PEDOT:PSS film were used for temperature sensing. The two sensors were integrated into a single electrode for performance evaluation. The integrated sensor exhibited a response of ΔR ≈ 0.14 to temperature variations from 20 °C to 100 °C with 20% RH humidity as a reference, and a response of ΔC ≈ 2.8 to relative humidity changes from 20% RH to 80% RH at 20 °C. The fabricated integrated sensor is expected to contribute to efficient temperature and humidity monitoring applications in various pouch-type lithium-ion batteries.

Traditional printed electronics processes have recently been utilized within 3D-printed structures where components and interconnects are introduced during manufacturing disruptions. The dielectric performance of 3D-printed materials has a low-resolution problem, and many technologies have been proposed for direct printing on a 3D curved surface or structure. This paper reports a humidity sensor fabricated with a 3D-printed electrode and cellulose nanofibers on a curved surface. The electrode part of an interdigital electrode (IDE) sensor is printed on a flat glass substrate and a 3D-curved glass substrate using a double blanket reverse offset. Subsequently, a cellulose nanofiber emulsion is coated onto the IDE pattern as a sensing layer with a dispenser. The electrical impedance of the sensor is measured with the relative humidity (RH) changes between 10% and 90% RH. The sensor demonstrates a high repeatability and sensitivity, even on a 3D curved substrate. This technology provides a promising method to integrate humidity sensors and 3D deformable surfaces.

Abstract The prevention of the loss of agricultural resources caused by pests is an important issue. Advances are being made in technologies, but current farm management methods and equipment have not yet met the level required for precise pest control, and most rely on manual management by professional workers. Hence, a pest detection system based on deep learning was developed for the automatic pest density measurement. In the proposed system, an image capture device for pheromone traps was developed to solve nonuniform shooting distance and the reflection of the outer vinyl of the trap while capturing the images. Since the black pine bast scale pest is small, pheromone traps are captured as several subimages and they are used for training the deep learning model. Finally, they are integrated by an image stitching algorithm to form an entire trap image. These processes are managed with the developed smartphone application. The deep learning model detects the pests in the image. The experimental results indicate that the model achieves an F1 score of 0.90 and mAP of 94.7% and suggest that a deep learning model based on object detection can be used for quick and automatic detection of pests attracted to pheromone traps.

Abstract. Background. Resting heart rate (RHR) is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients. Bisoprolol fumarate, a second-generation beta-adrenoreceptor blockers (β-blocker) is commonly prescribed drug to manage hypertension. The present study was to retrospectively evaluate changes in the average RHR and its association with cardiovascular outcomes in bisoprolol-treated coronary artery disease (CAD) patients from the CAD treated with bisoprolol (BISO-CAD) study who had comorbid hypertension. Methods. We performed ad-hoc analysis for hypertension sub-group of the BISO-CAD study (n = 866), which was a phase IV, multination, multi-center, single-arm, observational study carried out from October 2011 to July 2015 across China, South Korea, and Vietnam. Multivariate regression analysis was used to identify factors associated with incidence of composite cardiac clinical outcome (CCCO), the results were presented as adjusted odds ratio (OR) along with 95% confidence interval (CI) and adjusted P value. Results. A total of 681 patients (mean age: 64.77 ± 10.33 years) with hypertension from BISO-CAD study were included in the analysis. Bisoprolol improved CCCOs in CAD patients with comorbid hypertension, with RHR

The linear Weingarten condition with ellipticity for the mean curvature and the extrinsic Gaussian curvature on a surface in the three-sphere can define a Riemannian metric which is called the elliptic linear Weingarten metric. We established some local characterizations of the round spheres and the tori immersed in the 3-dimensional unit sphere, along with the Laplace operator, the spherical Gauss map and the Gauss map associated with the elliptic linear Weingarten metric.

Background/Aims Efficacy and safety data of alirocumab, a fully human monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), is not yet well established in the Korean population. We assessed them in ODYSSEY-KT through the pre-specified Korean subanalysis. Methods In the ODYSSEY-KT study, South Korean and Taiwanese patients with hypercholesterolemia and high cardiovascular risks were randomized (1:1) to alirocumab or placebo. Alirocumab was self-administered subcutaneously at 75 mg every 2 weeks with a maximally tolerated statin dose with or without other lipid-modifying therapies. Alirocumab dose was increased to 150 mg every 2 weeks at week 12 if low density lipoprotein cholesterol (LDL-C) ≥ 70 mg/dL at week 8. Primary endpoint was percent change in LDL-C from baseline to week 24. Results from Korean cohort (n = 83: 40 for alirocumab and 43 for placebo, respectively) analyses are reported here. Results In alirocumab group, the least square of mean change percent in LDL-C levels was –65.7% (placebo: 11.1%; p < 0.0001) and 92.0% of them achieved LDL-C < 70 mg/dL (placebo: 12.7%; p < 0.0001) at week 24. Alirocumab also showed significantly greater improvements in high density lipoprotein cholesterol (HDL-C), non-HDL-C, total cholesterol, lipoprotein(a), and apolipoprotein B than placebo (p < 0.05). Two consecutive calculated LDL-C values < 25 mg/dL were observed in 37.5% of alirocumab-treated patients. Overall, 45.0% alirocumab-treated and 51.2% placebo-treated patients experienced treatment-emergent adverse events (TEAEs) without discontinuation of treatment due to TEAEs. Conclusions Alirocumab has demonstrated to be effective in improvement of LDL-C and related lipid profiles in Korean cohort. Alirocumab was generally well tolerated with no significant safety signals.

Extraction of old pacemaker leads remains a complex procedure owing to fibrotic encapsulation and lead adhesions. We report a case of extraction of 15-year-old pacemaker leads by weight and pulley method. A 81-year-old man presented with exposed pacemaker leads out of body with purulent discharge from a pacemaker insertion site. He inserted DDD (dual chamber pacing, dual chamber sensing dual function) pacemaker implantation 15 years ago for SSS. Previously pacemaker battery was removed 3 years ago due to recurrent infection of pacemaker scar site. We extracted the pacemaker leads by weight and pulley method successfully without any complications.

In this study, the identification of dominant fish species in the East Sea was conducted using the dB-difference method. The survey was conducted using the two frequencies of 38 and 120 kHz in transect 6 of the southern part of the East Sea. Information on fish species was identified using fishing gear and e-DNA, and the dominant target fish species were selected and analyzed as cod, anchovy, common squid, and herring. The dB-difference range for each fish species was set to −0.86 dB < ∆MVBS 38–120 kHz < 0.82 dB for cod and to the range of 2.66 dB < ∆MVBS 38–120 kHz < 2.84 dB for anchovy. The dB-difference of the common squid was set to −0.36 dB < ∆MVBS 38–120 kHz < 1.25 dB and to the range of 0.88 dB < ∆MVBS 38–120 kHz < 2.28 dB for herring; the fish species were then identified in the echograms. When comparing the results of swimming depths by fish species and previous studies, cod was detected mainly at the bottom of the sea, and anchovy and common squid were detected mainly at a depth of 50 m. Herring was detected to be mainly distributed in water depths from 50 to 150 m.

Abstract In order to evaluate the maximal storable period of the raw crab for a non-thermal muscle separation, the quality changes of the leg meat of red snow crab (Chionoecetes japonicus) during freeze storage were investigated. Fresh red snow crabs were stored at −20 °C for 7 weeks, and the leg muscle was separated by a no heating separation (NHS) method every week. During the storage, considerable loss of the leg muscle did not occur and microbiological risk was very low. In contrast, discoloration appeared at 2-week storage on around carapace and the leg muscle turned yellow at storage 3-week. In physiochemical parameters, protein and free amino acids gradually decreased with storage time, expected that proteolytic enzymes still activated at −20 °C. At 4-week storage, the sensory acceptance dropped down below point 4 as low as inedible and notable inflection points in pH and acidity were observed. The volatile base nitrogen was low, though a little increase was recorded. These results suggested that the maximal storable period at −20 °C of the raw material was within 2 weeks and it was depended on external factor such as the discoloration. The present study might be referred as basic data for approaches to solve quality loss occurred in non-thermal muscle separation.

Background and Objectives: Magnetic resonance imaging (MRI) and the Prostate Imaging-Reporting and Data System (PI-RADS) have become essential tools for prostate cancer evaluation. We evaluated the ability of PI-RADS scores in identifying significant prostate cancer, which would help avoid unnecessary prostate biopsies. Materials and Methods: Patients with prostate-specific antigen (PSA) levels ≤ 20 ng/mL, who underwent prostate MRI for evaluation from January 2018 to November 2019, were analyzed. Among them, 105 patients who received transrectal ultrasonography (TRUS)-guided biopsy were included. PSA, PI-RADS scores (low 1–2, high 3–5), biopsy results, and Gleason scores (GS) were evaluated. Biopsies with GS higher than 3 + 4 were considered as significant cancers and biopsies with no cancer or Gleason 3 + 3 were considered insignificant or no cancers. Results: Among the 105 patients, 45 patients had low PI-RADS and 60 had high PI-RADS scores. There were no patients with significant prostate cancer in the low PI-RADS groups. For the high PI-RADS group, 28 (46.7%) patients had significant cancer and 32 (53.3%) had insignificant or no cancer. The sensitivity and specificity of high PI-RADS to detect significant cancer was 100% and 58.4%, respectively. Positive predictive value was 46.7% and negative predictive value was 100%. Conclusions: Low PI-RADS scores on MRI did not show significant prostate cancer and surveillance should be considered in selected cases to prevent unnecessary invasive procedures and overdiagnosis.

This study presents a simplified analysis technique capable of predicting the dynamic behavior of a tripod suction pile subjected to a horizontal load. The first natural frequency of the system, horizontal displacement, and allowable rotation angle at the pile head were set as target physical quantities in accordance with substructure design requirements. In consideration of the physical characteristics of the tripod suction pile, the analysis was extended to the single pile-multi-pile-tripod-tower part to derive the influence factors. A possible displacement response function that could be applied to the intermediate pile range was also proposed. Thereafter, a detailed design was determined using an integrated load analysis, which included a turbine based on the basic design of simplified analysis method. Furthermore, the dynamic behavior of the offshore wind turbine at each installation stage was predicted using a numerical analysis and measured via field tests. The displacement at the pile head and the predicted value of the first natural frequency of the system were compared using the field-measured and numerical analysis values. The first natural frequency value produced by the simple analysis method showed an error range within 1%, and the displacement at the pile head also satisfied the structural design requirements. Therefore, this method provides a quick and accurate solution to the lateral response of tripod suction piles as foundations for offshore wind turbines.

We characterize spheres and the tori, the product of the two plane circles immersed in the three-dimensional unit sphere, which are associated with the Laplace operator and the Gauss map defined by the elliptic linear Weingarten metric defined on closed surfaces in the three-dimensional sphere.

In this work, Nd–Fe–B alloy powders are fabricated via high energy ball milling and their fracture behavior and magnetic properties are investigated at different milling times. The powder characteristics (particle shape, size, size distribution, and microstructure) and magnetic properties of the Nd–Fe–B alloys are systematically analyzed. The initial spherical Nd–Fe–B powder is cracked/crushed even after a short period of milling (30 s) due to the high impact energy generated during high energy ball milling. These randomly cracked polygonal-shaped powders are fragmented after 5 min of milling and converted to fine powders. Interestingly, the fine particles after milling for 5 min are conducive to agglomeration at longer milling times (20–60 min) and formed spherically-shaped agglomerated powder. Additionally, the sphericity of the powder increased to 92% by re-pulverization and agglomeration at 60 min. The milled powder shows the Nd _2 Fe _14 B phase, and the x-ray diffraction patterns exhibit peak broadening with increasing milling time, clearly confirming the powder refinement behavior by high energy ball milling. The magnetic properties of the milled powders are systematically investigated and their behavior is elucidated as a function of the milling time.

For innate immune defense, lower animals such as fish and amphibian are covered with skin mucus, which acts as both a mechanical and biochemical barrier. Although several mucus sources have been isolated and studied for their biochemical and immunological functions, the precise mechanism(s) of action remains unknown. In the present study, we additionally found the eel skin mucus (ESM) to be a promising candidate for use in anti-tumor therapy. Our results showed that the viability of K562 cells was decreased in a dose-dependent manner by treatment with the isolated ESM. The cleaved forms of caspase-9, caspase-3 and poly adenosine diphosphate-ribose polymerase were increased by ESM. The levels of Bax expression and released cytochrome C were also increased after treatment with ESM. Furthermore, during the ESM mediated-apoptosis, phosphorylation levels of ERK1/2 and p38 but not JNK were increased and cell viabilities of the co-treated cells with ESM and inhibitors of ERK 1/2 or p38 were also increased. In addition, treatment with lactose rescued the ESM-mediated decrease in cell viability, indicating lactose-containing glycans in the leukemia cells acted as a counterpart of the ESM for interaction. Taken together, these results suggest that ESM could induce mitochondria-mediated apoptosis through membrane interaction of the K562 human leukemia cells. To the best of our knowledge, this is the first observation that ESM has anti-tumor activity in human cells.

In the Euclidean space E n , hyperplanes, hyperspheres and hypercylinders are the only isoparametric hypersurfaces. These hypersurfaces are also the only ones with chord property, that is, the chord connecting two points on them meets the hypersurfaces at the same angle at the two points. In this paper, we investigate hypersurfaces in nonflat space forms with the so-called geodesic chord property and classify such hypersurfaces completely.

We study functions defined in the plane E 2 in which level curves are strictly convex, and investigate area properties of regions cut off by chords on the level curves. In this paper we give a partial answer to the question: Which function has level curves whose tangent lines cut off from a level curve segment of constant area? In the results, we give some characterization theorems regarding conic sections.

Due to the increasing demand of high accuracy in printed electronics industry at a micrometer-level, it is necessary to have a precise control scheme for web velocity and tension in the presence of disturbances. In this paper, a generalized mathematical model of non-linear control system is proposed and a systematic procedure is presented to design a backstepping controller taking the modified backstepping approach. With application of the proposed theory, a precise control algorithm is developed for a nonlinear two-span roll-to-roll web control system based on the backstepping method. The design parameters are chosen optimally by using the modified genetic algorithm. The reliability of the proposed algorithm is validated through simulations in Matlab/Simulink and real experiments

There are many important applications in printed electronics and publishing industries that use the principle of roll-to-roll manufacturing to make printed electronic devices with lower cost. Web velocity and tension control algorithm plays an important role in improving the quality of product in mass processing of using roll-to-roll web technology. Most algorithms proposed in recent years use PI or PID controllers and disturbance compensation schemes to increase the precision and the stability. Due to the increasing demand of high accuracy in printed electronics industry at micrometer-level, it is necessary to have a precise control scheme of web velocity and tension in the presence of disturbances. In this paper, a precise control algorithm is proposed for non-linear single-span roll-to-roll web control system using the back-stepping controller with the design parameters chosen optimally by using the modified genetic algorithm. The outcome of this study proves the reliability throughout simulation results in Matlab/Simulink and in comparison to the experimental results

In this paper, we study submanifolds in a Euclidean space with a generalized 1-type Gauss map. The Gauss map, G, of a submanifold in the n-dimensional Euclidean space, En, is said to be of generalized 1-type if, for the Laplace operator, Δ, on the submanifold, it satisfies ΔG=fG+gC, where C is a constant vector and f and g are some functions. The notion of a generalized 1-type Gauss map is a generalization of both a 1-type Gauss map and a pointwise 1-type Gauss map. With the new definition, first of all, we classify conical surfaces with a generalized 1-type Gauss map in E3. Second, we show that the Gauss map of any cylindrical surface in E3 is of the generalized 1-type. Third, we prove that there are no tangent developable surfaces with generalized 1-type Gauss maps in E3, except planes. Finally, we show that cylindrical hypersurfaces in En+2 always have generalized 1-type Gauss maps.

Simultaneous leakage of soil particles and groundwater into underground vacant spaces caused by sewer pipe defects and cracks can cause underground cavities and even ground collapse on the surface. Numerical studies of this problem are limited, and the mechanism of ground subsidence caused by leakage of soil and groundwater into construction sites has yet to be verified. In this study, the factors affecting the mechanism of ground subsidence are verified via physical modelling of a sewer pipe defect. Through visual inspection and particle image velocimetry analysis, it has been found that the groundwater flow direction, hydraulic gradient around the leakage point, and strength of the ground to support itself are the main factors that dominate the mechanism of ground subsidence. These factors can affect ground deformation and cavity expansion direction, ground subsidence development and collapse speed, and occurrence of sudden ground collapse, respectively. It was also found that pore pressure fluctuates when cavity cavern collapse and cavity expansion occur.

Our principal goal is to study the prescribed curvature problem in a manifold with density. In particular, we consider the Euclidean 3-space R 3 with a positive density function e ϕ , where ϕ = - x 2 - y 2 , ( x , y , z ) ∈ R 3 and construct all the helicoidal surfaces in the space by solving the second-order non-linear ordinary differential equation with the weighted Gaussian curvature and the mean curvature functions. As a result, we give a classification of weighted minimal helicoidal surfaces as well as examples of helicoidal surfaces with some weighted Gaussian curvature and mean curvature functions in the space.

For the mean curvature vector field H and the Laplace operator Δ of a submanifold in the Minkowski space, a submanifold satisfying the condition Δ H = f H + g C is known as a generalized null 2-type, where f and g are smooth functions, and C is a constant vector. The notion of generalized null 2-type submanifolds is a generalization of null 2-type submanifolds defined by B.-Y. Chen. In this paper, we study flat surfaces in the Minkowski 3-space L 3 and classify generalized null 2-type flat surfaces. In addition, we show that the only generalized null 2-type null scroll in L 3 is a B-scroll.

Purpose: This study analyzed changes in body composition and physical fitness in men with testosterone deficiency (TD) after testosterone treatment (TT) and examined the correlations of body composition and physical fitness with serum testosterone levels and hypogonadal symptoms. Materials and Methods: Seventy patients with TD were divided into control (group I, n=23) and experimental (group II, n=47) groups. Patients in the experimental group were administered intramuscular testosterone enanthate (250 mg) for six months. The aging males symptom scale (AMS) score, international prostate symptom score (IPSS), body mass index, waist circumference, and serum laboratory values were measured at baseline and at the end of the study. Bioelectrical impedance analysis was used to assess the patients’ body composition. Seven types of basic exercise tests were used to evaluate the patients’ physical fitness. Results: After six months, there were no significant differences in group I, while group II had significantly improved IPSS and AMS scores; increased hemoglobin, hematocrit, prostate-specific antigen, and testosterone levels and skeletal muscle mass; and waist circumference, and body fat mass. All elements of the physical fitness test were significantly improved in group II, with the exceptions of flexibility and endurance. Decreased waist circumference was correlated with changes in testosterone levels in group II, and the IPSS, cardiorespiratory fitness, and agility were correlated with improved hypogonadal symptoms. Conclusions: TT improved the hypogonadal and lower urinary tract symptoms in patients with TD and improved body composition, physical fitness, and metabolic syndrome parameters. Increased testosterone and improved hypogonadal symptoms were correlated with a decrease in waist circumference and an improvement in cardiorespiratory fitness and agility. As such, when implementing TT, we should consider whether these areas may be improved, as this can help to predict the effect. [ABSTRACT FROM AUTHOR]