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In order to reduce the energy consumption of data centers in the southern coastal region and enhance the analysis of the water cold storage system, the water cold storage system was selected as the energy storage solution based on the cooling load of data centers in the Pearl River Delta region and the local time-of-use tariff policy. First, the water cold storage system and operation control scheme were optimized; second, the operation situation, energy consumption and economy of the water cold storage system were analyzed for typical days, months and whole year. The results show that the optimized water cold storage system can guarantee the indoor end-load demand and operate efficiently, and the annual cooling operation cost is reduced by 25.78%, which has a good effect of "peak-load shifting effect" and reduces the cooling electricity cost significantly.

While life-sustaining, hemodialysis is a non-physiological treatment modality that exerts stress on the patient, primarily due to fluid shifts during ultrafiltration. Automated feedback control systems, integrated with sensors that continuously monitor bio-signals such as blood volume, can adjust hemodialysis treatment parameters, e.g., ultrafiltration rate, in real-time. These systems hold promise to mitigate hemodynamic stress, prevent intradialytic hypotension, and improve the removal of water and electrolytes in chronic hemodialysis patients. However, robust evidence supporting their clinical application remains limited. Based on an extensive literature research, we assess feedback-controlled ultrafiltration systems that have emerged over the past three decades in comparison to conventional hemodialysis treatment. We identified 28 clinical studies. Closed loop ultrafiltration control demonstrated effectiveness in 23 of them. No adverse effects of closed loop ultrafiltration control were reported across all trials. Closed loop ultrafiltration control represents an important advancement towards more physiological hemodialysis. Its development is driven by innovations in real-time bio-signals monitoring, advancement in control theory, and artificial intelligence. We expect these innovations will lead to the prevalent adoption of ultrafiltration control in the future, provided its clinical value is substantiated in adequately randomized controlled trials. [ABSTRACT FROM AUTHOR]

Acclimatization of short-cut denitrifying polyphosphate accumulating organisms (SDPAOs), metabolic mechanism, and operating parameters were analyzed to investigate the performance of the anaerobic/anoxic sequencing batch reactor (A2SBR) process. The high-throughput sequencing technology was employed to explore the microbial community structures of activated sludge systems. The experimental results illustrated that SDPAOs were successfully enriched with three-phase inoculation for 36 days. The removal rates of TP and NO2−-N were 93.22% and 91.36%, respectively, under the optimal parameters of a pH of 7.5, an SRT of 26 days, a temperature of 24 ℃ and a COD of 200.00 mg·L−1 using acetate as the carbon source. In the anaerobic stage, 82.20% external carbon source was converted into 88.78 mg·g−1 PHB, and the removal rate of NO2−-N in the anoxic stage was characterized by ΔNO2−-N/ΔPHB, anoxic ΔP/ΔPHBeffective was 0.289, which was higher than anaerobic ΔP/ΔCODeffective of 0.203. Ignavibacterium and Povalibacter with significant phosphorus removal ability were the dominant bacterial genera. The nitrogen and phosphorus removal could be realized simultaneously in an anaerobic/anoxic sequencing batch reactor. Therefore, this study provided an important understanding of the removal of nitrogen and phosphorus from low-carbon nitrogen wastewater. [ABSTRACT FROM AUTHOR]

The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is continuously producing new variants, necessitating effective therapeutics. Patients are not only confronted by the immediate symptoms of infection but also by the long‐term health issues linked to long COVID‐19. Activation of epidermal growth factor receptor (EGFR) signalling during SARS‐CoV‐2 infection promotes virus propagation, mucus hyperproduction, and pulmonary fibrosis, and suppresses the host's antiviral response. Over the long term, EGFR activation in COVID‐19, particularly in COVID‐19‐induced pulmonary fibrosis, may be linked to the development of lung cancer. In this review, we have summarised the significance of EGFR signalling in the context of SARS‐CoV‐2 infection. We also discussed the targeting of EGFR signalling as a promising strategy for COVID‐19 treatment and highlighted erlotinib as a superior option among EGFR inhibitors. Erlotinib effectively blocks EGFR and AAK1, thereby preventing SARS‐CoV‐2 replication, reducing mucus hyperproduction, TNF‐α expression, and enhancing the host's antiviral response. Nevertheless, to evaluate the antiviral efficacy of erlotinib, relevant clinical trials involving an appropriate patient population should be designed. [ABSTRACT FROM AUTHOR]