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23 results on '"Dong, Ze-Xi"'

9. Protective effect of 6-O-methyl-scutellarein on repeated cerebral ischemia/reperfusion in rats.

Author

Wu, Wen-Yu, Zhong, Yue, Lu, Yu-Ting, Sun, Ying, Li, Nian-Guang, Shi, Zhi-Hao, Dong, Ze-Xi, Gu, Ting, Xue, Xin, Fang, Fang, Li, He-Min, Tang, Yu-Ping, and Duan, Jin-Ao

Subjects
NEURONS, ANALYSIS of variance, ANIMAL experimentation, ANTIOXIDANTS, BIOCHEMISTRY, CEREBRAL ischemia, FISHER exact test, HISTOLOGICAL techniques, NEUROLOGIC examination, NIMODIPINE, REPERFUSION, RESEARCH funding, SPACE perception, STATISTICS, DATA analysis, REPEATED measures design, DESCRIPTIVE statistics, FLAVONES, WOUNDS & injuries, THERAPEUTICS
Abstract

Scutellarin (1) possesses protective effects against neuronal injury, while 6-O-methyl-scutellarein (3), as the main metabolite of scutellarin in vivo, has not been reported about its protective effects previously. The present study mainly investigated whether the neural injury caused by ischemia/reperfusion would be influenced by different doses of 6-O-methyl-scutellarein (3). The results of behavioral, neurological, and histological examinations indicated that 6-O-methyl-scutellarein (3) could improve neuronal injury, and exhibit significant difference among the various doses. More importantly, 6-O-methyl-scutellarein (3) had better protective effects than scutellarin in rat cerebral ischemia. [ABSTRACT FROM AUTHOR]

Published
2018
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13. [Protective mechanism of cerebrospinal fluid containing qingxin kaiqiao recipe on PC12 cell injury induced by glutamate]

Author

Hai-Yan, Hu, Dong-Ze, Xi, Lei, Lei, Xiang, Chen, and Wen-Hua, Wang

Subjects
Male, Rats, Sprague-Dawley, Neuroprotective Agents, Proto-Oncogene Proteins c-bcl-2, Caspase 3, Animals, Glutamic Acid, Apoptosis, Medicine, Chinese Traditional, PC12 Cells, Cerebrospinal Fluid, Rats
Abstract

To study the protective effect of cerebrospinal fluid containing Qingxin Kaiqiao recipe on PC12 cell injury induced by glutamate (Glu), in order to provide basis for the conical application of the recipe.SD rats were orally administered with decoction of Qingxin Kaiqiao recipe (7.9 g x kg(-1)) for three and a half days, 2 times a day, in order to prepare cerebrospinal fluid containing Qingxin Kaiqiao recipe. PC cells were divided into the normal group, the model group, the nimodipine group, the 10% normal CSF group, the 10% medicated CSF group, the 20% normal CSF group, the 20% medicated CSF group. Except for the normal group, other groups were cultured with PC12 cells and Glu with the final concentration of 20 mmol x L(-1) to establish the nerve cell injury model. Apart from the model group and the normal group, other groups were intervened with nimodipine, normal cerebrospinal fluid, and 10% and 20% medicated CSF. RT-PCR was used to detect the expression level of Bax mRNA, Bcl-2 mRNA and Caspase-3 mRNA, and MTT method was used to detect the activity of PC12 cells.The activity of PC12 cells of all of medicated CSF groups was higher than that of the model group, with the decrease in the expression of Bax mRNA and Caspase-3 mRNA and the increase in the expression of Bcl-2 mRNA. They showed a significant different with the model group (P0.01). The 20% medicated CSF group was superior than the 10% medicated CSF group (P0.01).Qingxin Kaiqiao recipe shows an apparent protective effect on PC12 cells injured by Glu.

Published
2013

14. An Improved Synthesis of 6-O-Methyl-Scutellarein through Selective Benzylation

Author

Zhang, Wei, primary, Dong, Ze-Xi, additional, Gu, Ting, additional, Li, Nian-Guang, additional, Wu, Wen-Yu, additional, Zhang, Peng-Xuan, additional, Tang, Yu-Ping, additional, Yang, Jian-Ping, additional, Xue, Xin, additional, Fang, Fang, additional, Li, He-Min, additional, Cheng, Hai-Bo, additional, Duan, Jin-Ao, additional, and Shi, Zhi-Hao, additional

Published
2015
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16. A New and Practical Synthetic Method for the Synthesis of 6-O-Methyl-scutellarein: One Metabolite of Scutellarin in Vivo

Author

Lin, Hang, primary, Zhang, Wei, additional, Dong, Ze-Xi, additional, Gu, Ting, additional, Li, Nian-Guang, additional, Shi, Zhi-Hao, additional, Kai, Jun, additional, Qu, Cheng, additional, Shang, Guan-Xiong, additional, Tang, Yu-Ping, additional, Fang, Fang, additional, Li, He-Min, additional, Yang, Jian-Ping, additional, and Duan, Jin-Ao, additional

Published
2015
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19. Microwave-Assisted Esterification of Gallic Acid

Author

Shi, Zhi-Hao, primary, Li, Nian-Guang, additional, Tang, Yu-Ping, additional, Shi, Qian-Ping, additional, Zhang, Wei, additional, Zhang, Peng-Xuan, additional, Li, Wei, additional, Dong, Ze-Xi, additional, and Duan, Jin-Ao, additional

Published
2015
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22. Studies on the Protective Effects of Scutellarein against Neuronal Injury by Ischemia through the Analysis of Endogenous Amino Acids and Ca2+ Concentration Together with Ca2+-ATPase Activity.

Author

Tang, Hao, Dong, Ze-Xi, Gu, Ting, Li, Nian-Guang, Tang, Yu-Ping, Shi, Qian-Ping, Guo, Jian-Ming, Zhang, Peng-Xuan, and Duan, Jin-Ao

Subjects
*NERVOUS system injuries, *EXTRACTION (Chemistry), *PLANT extracts, *MEDICINAL plants, *BIOCHEMISTRY, *THERAPEUTICS
Abstract

Scutellarin, which is extracted from the dried plant of Erigeron breviscapus, has been reported to protect the neural injury against excitotoxicity induced by ischemia. However, there are a few studies on the protective effects of scutellarein, which is the main metabolite of scutellarin in vivo. Thus, this study investigated the neuroprotective effects of scutellarein on cerebral ischemia/reperfusion in rats by bilateral common carotid artery occlusion (BCCAO) model, through the analysis of endogenous amino acids using HILIC-MS/MS, and evaluation of Ca2+ concentration together with Ca2+-ATPase activity. The results showed that scutellarein having good protective effects on cerebral ischemia/reperfusion might by decreasing the excitatory amino acids, increasing the inhibitory amino acids, lowing intracellular Ca2+ level, and improving Ca2+-ATPase activity, which suggested that scutellarein might be a promising potent agent for the therapy of ischemic cerebrovascular disease. [ABSTRACT FROM AUTHOR]

Published
2015
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23. Studies on the Protective Effects of Scutellarein against Neuronal Injury by Ischemia through the Analysis of Endogenous Amino Acids and Ca2+ Concentration Together with Ca2+-ATPase Activity

Author

Tang, Hao, Dong, Ze-Xi, Gu, Ting, Li, Nian-Guang, Tang, Yu-Ping, Shi, Qian-Ping, Guo, Jian-Ming, Zhang, Peng-Xuan, and Duan, Jin-Ao

Abstract

Scutellarin, which is extracted from the dried plant of Erigeron breviscapus, has been reported to protect the neural injury against excitotoxicity induced by ischemia. However, there are a few studies on the protective effects of scutellarein, which is the main metabolite of scutellarin in vivo. Thus, this study investigated the neuroprotective effects of scutellarein on cerebral ischemia/reperfusion in rats by bilateral common carotid artery occlusion (BCCAO) model, through the analysis of endogenous amino acids using HILIC-MS/MS, and evaluation of Ca2+ concentration together with Ca2+-ATPase activity. The results showed that scutellarein having good protective effects on cerebral ischemia/reperfusion might by decreasing the excitatory amino acids, increasing the inhibitory amino acids, lowing intracellular Ca2+ level, and improving Ca2+-ATPase activity, which suggested that scutellarein might be a promising potent agent for the therapy of ischemic cerebrovascular disease.

Published
2015
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