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5 results on '"Dong, Yangdou"'

1. Repeated pulmonary nodules as the primary symptom of familial hemophagocytic lymphohistiocytosis in adults: a case report and review

Author

Zhang, Lulu, primary, Dong, Chuanchuan, additional, Wu, Qiannan, additional, Li, Yupeng, additional, Feng, Liting, additional, Xing, Yanqing, additional, Dong, Yangdou, additional, Liu, Le, additional, Li, Xiaohui, additional, Huo, Rujie, additional, Dong, Yanting, additional, Cheng, Erjing, additional, Ge, Xiaoyan, additional, and Xinrui, Tian, additional

Published
2023
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3. Exploration and Validation of Potential Biomarkers and Therapeutic Targets in Ferroptosis of Asthma

Author

Xing,Yanqing, Feng,Liting, Dong,Yangdou, Li,Yupeng, Zhang,Lulu, Wu,Qiannan, Huo,Rujie, Dong,Yanting, Tian,Xinrui, Tian,Xinli, Xing,Yanqing, Feng,Liting, Dong,Yangdou, Li,Yupeng, Zhang,Lulu, Wu,Qiannan, Huo,Rujie, Dong,Yanting, Tian,Xinrui, and Tian,Xinli

Abstract

Yanqing Xing,1 Liting Feng,1 Yangdou Dong,2 Yupeng Li,1 Lulu Zhang,1 Qiannan Wu,1 Rujie Huo,1 Yanting Dong,1 Xinrui Tian,1 Xinli Tian3 1Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2College of Basic Medicine, Shanxi Medical University, Taiyuan, People’s Republic of China; 3Department of Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xinrui Tian, Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University, No. 382, Wuyi Road, Xinghualing District, Taiyuan, People’s Republic of China, Tel +8613834575570, Email tianxr@126.com Xinli Tian, Department of Cardiology, Chinese PLA General Hospital, No. 7 Medical Center No. 5 Nanmencang, Dongsijiao, Dongcheng District, Beijing, People’s Republic of China, Email 18600501329@126.comPurpose: Asthma is a chronic inflammatory airway disease involving multiple mechanisms, of which ferroptosis is a form of programmed cell death. Recent studies have shown that ferroptosis may play a crucial role in the pathogenesis of asthma, but no specific ferroptosis gene has been found in asthma, and the exact mechanism is still unclear. The present study aimed to screen ferroptosis genes associated with asthma and find therapeutic targets, in order to contribute a new clue for the diagnosis and therapy of asthma.Methods: Ferroptosis-related differentially expressed genes (FR-DEGs) in asthma were selected by the GSE41861, GSE43696 and ferroptosis datasets. Next, the FR-DEGs were subjected by GO and KEGG enrichment, and the mRNA-miRNA network was constructed. Then, GSEA and GSVA enrichment analysis and Immune infiltration analysis were performed, followed by targeted drug prediction. Finally, the expression of FR-DEGs was confirmed using GSE63142 dataset and RT-PCR assay.Results: We found 13 FR-DEGs by the GSE41861, GSE43696 and ferroptosis database. Funct

Published
2023

5. Tetramisole is a new IK1 channel agonist and exerts IK1‐dependent cardioprotective effects in rats.

Author

Liu, Qinghua, Sun, Jiaxing, Dong, Yangdou, Li, Pan, Wang, Jin, Wang, Yulan, Xu, Yanwu, Tian, Xinrui, Wu, Bowei, He, Peifeng, Yu, Qi, Lu, Xuechun, and Cao, Jimin

Subjects
MYOCARDIAL reperfusion, ACTION potentials, ARRHYTHMIA, CARDIAC hypertrophy, POTASSIUM channels, MEMBRANE potential, DRUG repositioning, CARDIOTONIC agents
Abstract

Cardiac ischemia, hypoxia, arrhythmias, and heart failure share the common electrophysiological changes featured by the elevation of intracellular Ca2+ (Ca2+ overload) and inhibition of the inward rectifier potassium (IK1) channel. IK1 channel agonists have been considered a new type of anti‐arrhythmia and cardioprotective agents. We predicted using a drug repurposing strategy that tetramisole (Tet), a known anthelminthic agent, was a new IK1 channel agonist. The present study aimed to experimentally identify the above prediction and further demonstrate that Tet has cardioprotective effects. Results of the whole‐cell patch clamp technique showed that Tet at 1–100 μmol/L enhanced IK1 current, hyperpolarized resting potential (RP), and shortened action potential duration (APD) in isolated rat cardiomyocytes, while without effects on other ion channels or transporters. In adult Sprague–Dawley (SD) rats in vivo, Tet showed anti‐arrhythmia and anticardiac remodeling effects, respectively, in the coronary ligation‐induced myocardial infarction model and isoproterenol (Iso, i.p., 3 mg/kg/day, 10 days) infusion‐induced cardiac remodeling model. Tet also showed anticardiomyocyte remodeling effect in Iso (1 μmol/L) infused adult rat ventricular myocytes or cultured H9c2 (2‐1) cardiomyocytes. Tet at 0.54 mg/kg in vivo or 30 μmol/L in vitro showed promising protections on acute ischemic arrhythmias, myocardial hypertrophy, and fibrosis. Molecular docking was performed and identified the selective binding of Tet with Kir2.1. The cardioprotection of Tet was associated with the facilitation of IK1 channel forward trafficking, deactivation of PKA signaling, and inhibition of intracellular calcium overload. Enhancing IK1 may play dual roles in anti‐arrhythmia and antiventricular remodeling mediated by restoration of Ca2+ homeostasis. [ABSTRACT FROM AUTHOR]

Published
2022
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