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In order to realize the rational development, scientific management and effective protection of water resources, the Chinese government adopts the water function zoning management system to protect water resources. Over the past decade, the water quality in China has become better, and the most areas whose water quality under the goal of water function zone has become better heading to the goal required by this system. However, water quality in a few areas that was better than the goal has getting close to the goal. As a result, this study presents the concept of the trend balance of water quality based on the water function zoning management system. To verify these trend balance points, this study takes the main stream of the Yangtze River as the research area and the time evolution trend of the Yangtze River water quality was studied based on the analysis of big data. The Dickey-Fuller Test was used to test the stability of the water quality time series. It was found that more than 90% of the river sections whose DO and TP have stabilized, and 60% of the sections whose CODMn, NH3-N, BOD5, Pb, and OIL have stabilized, indicating that the water quality of the main stream of the Yangtze River has a steady trend in time evolution. That proves the water quality of the mainstream of the Yangtze River exists trend balance points, which means the water quality will tend to be an equilibrium state that gradually approaches the control target of this system and ultimately fluctuates up and down. Keywords: water function zoning management system; the Yangtze River; big data [ABSTRACT FROM AUTHOR]

Lung cancer accounts for the highest cancer-related mortality worldwide. While immunotherapies targeting anti-tumor immune responses have demonstrated efficacy in clinical practice, the demand for novel treatment modalities remains urgent. Oncolytic viruses (OVs), which selectively kill tumor cells while stimulating an anti-tumor immune response, represent a potential breakthrough in lung cancer therapy. The induction of anti-tumor immunity by OVs is central to their overall therapeutic effectiveness. Many natural receptors on the surface of cancer cells are dysregulated, providing potential entry points for OVs. Furthermore, the inherent dysregulation of some key signaling pathways in lung cancer cells promotes proliferation, progression and metastasis, which may facilitate selective viral replication. In this review, we explore the application of OVs in lung cancer by analyzing several major OVs and their corresponding entry receptors. Then, we also examine the key signaling pathways and molecules with the potential to synergize with OVs in modulating the immune tumor microenvironment. Finally, we discuss the combination and administration strategies that warrant further clinical trials for validation. Despite certain limitations, the tolerability of OVs positions virotherapy as a promising avenue in the future of lung cancer treatment., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Dong, Luo, He, Zhang, Zeng and Chen.)