Search

Background: Limited information is available regarding the relative risks of cancer-specific mortality and noncancer-specific mortality among long-term survivors with differentiated thyroid cancer (DTC). Methods: In this retrospective study, nationwide data from the Surveillance, Epidemiology, and End Results database (1992-2020) were utilized. The Accelerated Failure Time Model was applied to calculate Survival Time Ratios (TR), with the primary focus on mortality resulting from DTC. The competing risks model was employed to investigate the relative risks of various outcomes in DTC patients with a survival duration of 5 years or more. Results: In our cohort, 279 patients succumbed to DTC, while 748 died from other diseases. Notably, in DTC cohorts, noncancer-specific mortality rates were consistently higher than DTC-specific mortality rates across different age groups and genders. The risk of DTC and noncancer-specific mortality varied based on the TNM stage. With more advanced disease stages, the risk of DTC and other cancer-specific mortality gradually increased. The cumulative mortality from other cancer-specific causes was consistently the lowest. Conclusions: In long-term surviving DTC patients, noncancer-specific mortality outweighed DTC-specific mortality irrespective of age and gender. For stage I and II patients, increased attention should be directed toward noncancer-specific mortality in postoperative follow-ups. Conversely, for stage III and IV patients, greater consideration should be given to DTC-related causes of death. In addition, for stage III and IV DTC patients, the risk of death from other cancers was significantly higher than for stages I and II. [ABSTRACT FROM AUTHOR]

By testing and analyzing the electrical characteristic data of signal equipment, it is possible to grasp the trend of equipment operation status and detect abnormal performance of signal equipment in advance. The electrical characteristic parameter indicators of signal equipment are related to their working modes. When the signal equipment operates in diff erent working modes, the magnitude of its operating voltage, current, and other values will change with changes in the working mode. In the case of multi-mode mixed-sampling statistics, it is difficult to quickly distinguish between normal and abnormal changes in data. Taking signal equipment such as tracks and switches as examples, this study explores new ideas for statistical analysis of operating trends of signal equipment in multi-state mode through working mode recognition, data sampling, and statistical analysis of electrical characteristics trends in diff erent modes. [ABSTRACT FROM AUTHOR]

Papillary thyroid carcinoma (PTC) is the most prevalent endocrine-related malignancy. In spite of the good prognosis, a more aggressive disease can develop in some PTC patients, leading to poor survival. Nuclear paraspeckle assembly transcript 1 (NEAT1) enhances tumorigenesis; however, the relationship between NEAT1_2 and glycolysis in PTC has not been identified. The expressions of NEAT1_2, KDM5B, Ras-related associated with diabetes (RRAD), and EHF were determined by quantitative reverse transcription polymerase chain reaction and immunocytochemistry. The effects of NEAT1_2, KDM5B, RRAD, and EHF on PTC glycolysis were ascertained employing in vitro as well as in vivo experiments. Chromatin immunoprecipitation (ChIP), RNA binding protein immunoprecipitation, luciferase reporter assays, and co-immunoprecipitation were utilized to analyze the binding abilities among NEAT1_2, KDM5B, RRAD, and EHF. Overexpression of NEAT1_2 was associated with glycolysis in PTC. NEAT1_2 could activate glycolysis by regulating the expression of RRAD in PTC. NEAT1_2 mediated H3K4me3 modification at the promoter of RRAD by recruiting KDM5B. RRAD further negatively regulated glycolysis by binding and regulating the subcellular location of the transcription factor EHF. EHF could activate the transcription of NEAT1_2, hexokinase 2, and pyruvate kinase M2, thereby forming the NEAT1_2/RRAD/EHF feedback loop. Our study revealed that the NEAT1_2/RRAD/EHF positive feedback loop facilitated glycolysis in PTC, which might avail meaningful insight for PTC management. [ABSTRACT FROM AUTHOR]

Objective: Papillary thyroid microcarcinoma (PTMC) comprises more than 50% of all newly detected cases of papillary thyroid carcinoma (PTC). High‐volume lymph node metastasis (involving >5 lymph nodes) (hv‐LNM) is associated with PTMC recurrence. In half of the clinically node‐negative (cN0) PTMC patients, central lymph node metastasis (CLNM) is pathologically present. However, clinical risk factors for high‐volume CLNM (hv‐CLNM) in cN0 PTMC have not been defined well. Therefore, we aimed to obtain evidence for hv‐CLNM risk factors in cN0 PTMC. Design: Data on patients who visited our hospital between January 2020 and December 2021 were collected; a preoperative diagnosis of cN0 and a postoperative pathological confirmation of PTMC were obtained. After filtering by inclusion versus exclusion criteria, the obtained data (N = 2268) were included in the meta‐analysis. Relevant studies published as of 10 April 2022, were identified from the Web of Science, PubMed, WANFANG, and CNKI databases. These eligible studies were included in the meta‐analysis and the association between clinicopathological factors and hv‐CLNM in cN0 PTMC was assessed. SPSS and MetaXL were used for statistical analyses. Results: The meta‐analysis included 10 previous studies (11,734 patients) and 2268 patients enroled in our hospital for a total of 14,002 subjects. The results of which suggested that younger age (<40, odds ratio [OR] = 3.28, 95% confidence interval [CI] = 2.75–3.92, p <.001 or <45 odds ratio [OR] = 2.93, 95% CI = 2.31–3.72, p <.001), male sex (OR = 2.81, 95% CI = 2.25–3.52, p <.001), tumour size >5 mm (OR = 1.85, 95% CI = 1.39–2.47, p <.001), multifocality (OR = 1.88, 95% CI = 1.56–2.26, p <.001), extrathyroidal extension (OR = 2.58, 95% CI = 2.02–3.30, p <.001), capsule invasion (OR = 2.02, 95% CI = 1.46–2.78, p <.001), microcalcification (OR = 3.25, 95% CI = 2.42–4.36, p <.001) and rich blood flow (OR = 1.65, 95% CI = 1.21–2.25, p =.002) were the significant factors related to an elevated hv‐CLNM risk in cN0 PTMC patients. Hashimoto thyroiditis (OR = 0.76, 95% CI = 0.55–1.07, p =.114), irregular margin (versus regular margin, OR = 0.96, 95% CI = 0.68–1.33, p =.787) and hypoechoic (versus nonhypoechoic, OR = 1.27, 95% CI = 0.84–1.92, p =.261) showed no significant association with hv‐CLNM. Conclusions: Younger age, tumour size >5 mm, males, extrathyroidal extension, multifocality, microcalcification, capsular invasion, and rich blood flow were the significant clinicopathological risk factors for hv‐CLNM risk in cN0 PTMC patients. These predictors may compensate for the sensitivity of imaging diagnosis in the preoperative period, thus helping in the effective identification of PTMCs with an invasive phenotype. [ABSTRACT FROM AUTHOR]