152 results on '"Dong, Shi-Hui"'
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2. Genome mining of sulfonated lanthipeptides reveals unique cyclic peptide sulfotransferases
3. Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans.
4. Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes
5. Divergent Biosynthesis of Bridged Polycyclic Sesquiterpenoids by a Minimal Fungal Biosynthetic Gene Cluster
6. Functional elucidation of TfuA in peptide backbone thioamidation
7. Cytochalasins from Xylaria sp. CFL5, an Endophytic Fungus of Cephalotaxus fortunei
8. Genome Mining of Linaridins Provides Insights into the Widely Distributed LinC Oxidoreductases
9. Chemical constituents from Vernonia bockiana
10. Meroterpenoids with diverse ring systems and dioxolanone-type secondary metabolites from Phyllosticta capitalensis and their phytotoxic activity
11. Structural Biology of RiPP Natural Products Biosynthesis
12. Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop “Out” Conformation for LasR
13. Activation of silent biosynthetic gene clusters using transcription factor decoys
14. Molecular basis for the substrate specificity of quorum signal synthases
15. The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis
16. Ivorenoids A–F: limonoids from Khaya ivorensis
17. Chemical constituents from Brucea javanica
18. Lanthipeptides from the Same Core Sequence: Characterization of a Class II Lanthipeptide Synthetase from Microcystis aeruginosa NIES-88
19. Biochemical Reconstitution Reveals the Biosynthetic Timing and Substrate Specificity for Thioamitides
20. Correlational networking guides the discovery of cryptic natural product biosynthetic enzymes
21. Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor† †Electronic supplementary information (ESI) available: Experimental procedures, X-ray crystallographic data, and FP biding curves. See DOI: 10.1039/c8sc03173h
22. Phomotide A, a novel polyketide, from the endophytic fungus Phomopsis sp. CFS42
23. Cytochalasins from Xylaria sp. CFL5, an Endophytic Fungus of Cephalotaxus fortunei
24. shuang zi ye zhi wu fen lei
25. Interaction of CO and O2 with supported Pt single-atoms on TiO2(110)
26. Structure-Guided Biochemical Analysis of Quorum Signal Synthase Specificities
27. Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease
28. The biochemistry and structural biology of cyanobactin biosynthetic enzymes
29. Functional interactions between post-translationally modified amino acids of methyl-coenzyme M reductase inMethanosarcina acetivorans
30. Mechanistic Basis for Ribosomal Peptide Backbone Modifications
31. Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease
32. Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor
33. Activation of silent biosynthetic gene clusters using transcription factor decoys
34. Author response: Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease
35. Cytochalasins from Xylariasp. CFL5, an Endophytic Fungus of Cephalotaxus fortunei
- Abstract
Abstract: Three previously undescribed cytochalasins, named xylariasins A‒C (1‒3), together with six known ones (4‒9) were isolated from Xylariasp. CFL5, an endophytic fungus of Cephalotaxus fortunei. The chemical structures of all new compounds were elucidated on the basis of extensive spectroscopic data analyses and electronic circular dichroism calculation, as well as optical rotation calculation. Biological activities of compounds 1, 4‒9were evaluated, including cytotoxic, LAG3/MHC II binding inhibition and LAG3/FGL1 binding inhibition activities. Compounds 6and 9possessed cytotoxicity against AGS cells at 5 μM, with inhibition rates of 94% and 64%, respectively. In addition, all tested isolates, except compound 6, exhibited obvious inhibitory activity against the interaction of both LAG3/MHC II and LAG3/FGL1. Compounds 1, 5, 7, and 8inhibited LAG3/MHC II with IC
50 values ranging from 2.37 to 4.74 μM. Meanwhile, the IC50 values of compounds 1, 7, and 8against LAG3/FGL1 were 11.78, 4.39, and 7.45 μM, respectively. Graphic Abstract:
36. The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes
37. Interaction of CO and O2with supported Pt single-atoms on TiO2(110)
38. The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold
39. Author response: The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold
40. Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage
41. New triterpenoids with protein tyrosine phosphatase 1B inhibition from Cedrela odorata
42. Lipidated steroid saponins from Dioscorea villosa (wild yam)
43. Correction to Diarylheptanoids from Dioscorea villosa (Wild Yam)
44. Alkaloids from the Twigs and Leaves ofDaphniphyllum macropodum
45. Chemical constituents from Brucea javanica
46. Diarylheptanoids from Dioscorea villosa (Wild Yam)
47. Sesquiterpenes fromDysoxylum oliganthumandDysoxylum excelsum
48. Triterpenoids from Melia toosendan
49. ChemInform Abstract: Limonoids and Triterpenoids from the Seeds of Melia azedarach.
50. Constituents of Trigonostemon heterophyllus
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