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Nanosuspensions technique is an important tool to enhance the saturation solubility and dissolution velocity of poorly soluble drugs. Trans-resveratrol (t-Res) with extensive pharmacological effects was severely restricted by poor solubility and short biological half-life. In this study, anti-solvent precipitation was employed to development trans-resveratrol nanosuspensions (t-Res NS) with PVPK30 as stabilizer. The physicochemical properties, in vitro release and in vivo pharmacokinetics of t-Res NS were investigated. The mean particle size, zeta potential, encapsulation efficiency and drug loading of t-Res NS prepared by the optimal prescription were 96.9 nm, −20.4mV, 78% and 28.1%, respectively. The morphology of t-Res nanoparticles was spherical indicated by SEM with amorphous phase verified by XRD and DSC. The t-Res NS present a good physical stability as well as enhanced chemical stability. Compared to crude drug, the in vitro dissolution rate of t-Res NS was increased with fitting Higuchi equation ( Q = 0.3215 t 1 / 2 + 0.0070 ). The in vivo pharmacokinetic test in rats showed that the AUC 0 ∼ t of t-Res NS (559.4 μg/mL·min) was about 3.6-fold higher than that of t-Res solution. Meanwhile, the MRT of t-Res nanosuspensions was longer than that of t-Res solution. These results suggested that NS may be a potentially nanocarrier for clinical delivery of t-Res. [ABSTRACT FROM AUTHOR]

The article reports on the use of a macromolecular agent to modify the surface of native nano-sized silicon nitride powder. According to the authors, the modification was done to produce nano-silicon nitride/NBR composites. They report that an organic coating layer was formed once the macromolecular coupling agent covalently bonds on the surface of the silicon nitride particles. The agent also improved the hydrophobic property of the silicon nitride and enhanced its dispersability, while the oil resistance of NBR nanocomposites was also improved.