Search

Abstract Purpose Achieving and maintaining an optimal reduction in partially or fully displaced intra-articular fractures, specifically Type C distal radius fractures, can present challenges. This study aims to retrospectively evaluate and summarize a method utilizing multi-directional temporary Kapandji technique in combination with the volar locking plate fixation for these fractures. Method The study involved 15 patients diagnosed with Type C distal radius fractures who underwent surgery between January 2024 and April 2024. The procedure incorporated a multi-directional temporary Kapandji technique, followed by stable osteosynthesis using a volar locking plate system. The functional outcomes were assessed after 4 (2–6) months of follow-up using the modified Mayo wrist scoring system (MMWS). The MMWS is a rating system used to evaluate wrist function and pain, including pain, motion, grip strength. Results All the patients incision healed within 2 weeks. All the fractures had uneventful union within 8–12 weeks. Based on the modified Mayo wrist scoring (MMWS) system, most patients showed good to excellent functional recovery. Conclusion This reduction method proved to be both simple and replicable, enabling satisfactory alignment with minimal force. The volar locking plate system provided rigid and stable fixation.

Abstract Background Tribe Oenantheae consists mainly of aquatic species within the Apioideae. The unique morphology and habitat distinguish this group from other Apioideae groups. However, the genomic information of these group species has not been widely developed, and the molecular mechanisms of adaptive evolution remain unclear. Results We provide comparative analyses on 30 chloroplast genomes of this tribe representing five genera to explore the molecular variation response to plant adaptations. The Oenantheae chloroplast genomes presented typical quadripartite structures, with sizes ranging from 153,024 bp to 155,006 bp. Gene content and order were highly conserved with no significant expansion or contraction observed. Seven regions (rps16 intron–trnK, rpoB–trnC, trnE–trnT–psbD, petA–psbJ, ndhF–rpl32–trnL, ycf1a–rps15, and ycf1a gene) were identified as remarkable candidate DNA markers for future studies on species identification, biogeography, and phylogeny of tribe Oenantheae. Our study elucidated the relationships among the genera of tribe Oenantheae and subdivided the genera of Sium and Oenanthe. However, relationships among the Oenanthe I clade remain to be further clarified. Eight positively selected genes (accD, rbcL, rps8, ycf1a, ycf1b, ycf2, ndhF, and ndhK) were persuasively detected under site models tests, and these genes might have played roles in Oenantheae species adaptation to the aquatic environments. Conclusions Our results provide sufficient molecular markers for the subsequent molecular studies of the tribe Oenantheae, and promote the understanding of the adaptation of the Oenantheae species to aquatic environments.

Abstract Bacterial biofilms are one of the major contributors to the refractoriness of septic arthritis. Although nitric oxide (NO)-enhanced photodynamic (PDT) therapy has been involved in biofilm eradication, the anti-biofilm efficacy is usually hindered by the short half-life and limited diffusion distance of active molecules. Herein, we report a three-arm structure using the photosensitive core chlorin e6 to integrate three α-cyclodextrin (α-CD) polyrotaxane chains as the supramolecular nanocarrier of NO-enhanced PDT therapy, in which NO was loaded on the cationic rings (α-CDs). Beneficial from the enhanced permeability of the nanocarrier due to the collective act on biofilms by the molecular motions (slide and rotation of rings) of three chains in different directions, NO capable of inducing biofilm dispersal and reactive oxygen species were efficiently delivered deep inside biofilms under 660 nm laser irradiation, and reactive nitrogen species with stronger bactericidal ability was produced in-situ, further accomplishing bacteria elimination inside biofilms. In-vivo therapeutic performance of this platform was demonstrated in a rat septic arthritis model by eliminating the methicillin-resistant Staphylococcus aureus infection, and potentiating the immune microenvironment regulation and bone loss inhibition, also providing a promising strategy to numerous obstinate clinical infections caused by biofilms. Graphical Abstract

Abstract Background Obesity is a well-known risk factor for developing malignant tumors and promoting tumor cell growth and spread. However, recent studies have shown that obese cancer patients, who typically have a worse prognosis than nonobese cancer patients, show a significant improvement in survival after receiving immune checkpoint inhibitor (ICI) therapy. This phenomenon is known as the “obesity paradox”. However, this phenomenon is influenced by tumor type and sex. Therefore, this study aimed to explore the impact of obesity on immunotherapy efficacy from multiple perspectives, aiming to verify this paradox and provide new scientific evidence on the effect of obesity on ICI efficacy. Methods This retrospective study evaluated the data of patients who received ICI therapy between June 2019 and August 2023. Automatic segmentation of skeletal muscle, subcutaneous fat, and visceral fat was performed using Slice-O-Matic software, and the corresponding skeletal muscle index (SMI), subcutaneous fat index (SFI) and visceral fat index (VFI) were calculated. The neutrophil-to-lymphocyte ratio (NLR) was determined by dividing the neutrophil count by the lymphocyte count. Univariate and multivariate Cox regression analyses were used to evaluate the correlation between body mass index (BMI), body composition parameters, and the NLR with overall survival (OS) and progression-free survival (PFS) in obese patients receiving ICI therapy. Results We analyzed 219 patients with a median age of 60 years (IQR 53–69 years; 155 men and 64 women). Obese patients, particularly those with visceral fat accumulation, exhibited extended OS after ICI therapy (log­rank P = 0.027). Cox multivariate analysis revealed that the NLR (HR = 1.036; 95% CI: 0.996 to 1.078; P = 0.002) was independently associated with OS. Patients with a high NLR had worse OS than those with a low NLR. Conclusions This study corroborates the veracity of the "obesity paradox" under specific conditions and identifies NLR as an independent prognostic factor, with elevated NLR indicative of a poor prognosis.

Abstract Tertiary lymphoid structures are immune cell aggregates linked with cancer outcomes, but their interactions with tumour cell aggregates are unclear. Using nasopharyngeal carcinoma as a model, here we analyse single-cell transcriptomes of 343,829 cells from 77 biopsy and blood samples and spatially-resolved transcriptomes of 31,316 spots from 15 tumours to decipher their components and interactions with tumour cell aggregates. We identify essential cell populations in tertiary lymphoid structure, including CXCL13+ cancer-associated fibroblasts, stem-like CXCL13+CD8+ T cells, and B and T follicular helper cells. Our study shows that germinal centre reaction matures plasma cells. These plasma cells intersperse with tumour cell aggregates, promoting apoptosis of EBV-related malignant cells and enhancing immunotherapy response. CXCL13+ cancer-associated fibroblasts promote B cell adhesion and antibody production, activating CXCL13+CD8+ T cells that become exhausted in tumour cell aggregates. Tertiary lymphoid structure-related cell signatures correlate with prognosis and PD-1 blockade response, offering insights for therapeutic strategies in cancers.

Abstract Purpose The purpose of this study is to retrospect and summarize clinical efficiency and experience of the free superficial palmar branch of radial artery (SPBRA) flap for soft-tissue reconstruction in distal digital injury. Method 13 patients with soft-tissue defect of finger, reconstructed by the free superficial palmar branch of radial artery (SPBRA) flap in our department from January 2020 to January 2022, were reviewed. After 6–12 months of follow-up, evaluated the treatment effect of the fingers reconstructed by SPBRA flap. Results All the flaps in our series application were survival uneventful, and all the donor sites were closed primarily without complications or obvious scarring. The flaps were soft in texture and satisfactory in appearance and function. The flaps with the median nerve palmar cutaneous branch had a good sensation recovery. Measurement of two-point discrimination (TPD) ranged from 6 to 10 mm. All patients were satisfied with the aesthetic appearance. According to the Evaluation Trial Standards of Upper Limb Partial Function of Hand Surgery of Chinese Medical Association, the results were graded as excellent in 11 cases and good in 2 cases. Conclusion The SPBRA perforator flap has the advantages of simple operation, soft texture, good appearance and function, and is credible and useful for reconstructing various finger injuries.

Abstract Portal vein tumor thrombosis (PVTT) is one of the common complications of HCC and represents a sign of poor prognosis. PVTT signifies advanced liver cancer, deteriorating liver function, and heightened susceptibility to intrahepatic dissemination, systemic metastasis, and complications related to portal hypertension. It is important to seek novel strategies for PVTT arising from HCC. Portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC) represents a worse liver function, less treatment tolerance, and poor prognosis. This study aimed to investigate the diagnostic value of the combination of the DeRitis ratio (AST/ALT) and alkaline phosphatase (ALP) index (briefly named DALP) in predicting the occurrence risk of PVTT in patients with HCC. We performed a retrospective study enrolling consecutive patients with HCC from January 2017 to December 2020 in Hebei Medical University Third Hospital. ROC analysis was performed to estimate the predictive effectiveness and optimal cut-off value of DALP for PVTT occurrence in patients with HCC. Kaplan–Meier analysis revealed the survival probabilities in each subgroup according to the risk classification of DALP value. Univariate and multivariate Logistics regression analyses were applied to determine the independent risk for poor prognosis. ROC analysis revealed that the optimal cut-off value for DALP was 1.045, with an area under the curve (AUC) of 0.793 (95% CI 0.697–0.888). Based on the DALP classification (three scores: 0–2) with distinguishable prognoses, patients in the score 0 group had the best prognosis with a 1-year overall survival (OS) of 100%, whereas score 2 patients had the worst prognosis with 1-year OS of 72.4%. Similarly, there was a statistically different recurrence-free survival among the three groups. Besides, this risk classification was also associated with PVTT progression in HCC patients (odds ratio [OR] 5.822, P

Abstract In this paper, we systematically investigate the general dark matter-electron interactions within the framework of effective field theories (EFTs). We consider both the non-relativistic (NR) EFT and the relativistic EFT descriptions of the interactions with the spin of dark matter (DM) up to one, i.e., the scalar (ϕ), fermion (χ), and vector (X) DM scenarios. We first collect the leading-order NR EFT operators describing the DM-electron interactions, and construct especially the NR operators for the vector DM case. Next, we consider all possible leading-order relativistic EFT operators including those with a photon field and perform the NR reduction to match them onto the NR EFT. Then we rederive the DM-bound-electron scattering rate within the NR EFT framework and find that the matrix element squared, which is the key input that encodes the DM and atomic information, can be compactly decomposed into three terms. Each term is a product of a DM response function (a 0,1,2), which is essentially a factor of Wilson coefficients squared, and its corresponding generalized atomic response function W ~ 0 , 1 , 2 $$ \left({\overset{\sim }{W}}_{0,1,2}\right) $$ . Lastly, we employ the electron recoil data from the DM direct detection experiments (including XENON10, XENON1T, and PandaX-4T) to constrain all the non-relativistic and relativistic operators in all three DM scenarios. We set strong bounds on the DM-electron interactions in the sub-GeV region. Particularly, we find that the latest PandaX-4T S2-only data provide stringent constraints on dark matter with a mass greater than approximately 20 MeV, surpassing those from the previous XENON10 and XENON1T experiments.

Abstract Recently Belle II reported the first measurement of B + → K + + invisible(inv), which is 2.7σ above the standard model (SM) prediction. If confirmed, this calls for new physics beyond SM. In the SM, the invisible particles are neutrino-anti-neutrino pairs. There are more possibilities when going beyond the SM. In this work, we focus on decays to dark matter (DM) and show that the B → K + inv excess from Belle II and DM relic density can be simultaneously explained in a simple extension of the SM. The model introduces a real scalar singlet ϕ acting as a DM candidate, and two heavy vector-like quarks Q, D with the same quantum numbers as the SM left-handed quark doublet and right-handed down-type quark singlet, respectively. All these new particles are odd under a ℤ2 symmetry while the SM particles are even. The model can successfully explain the Belle II anomaly and DM relic density for TeV-scale heavy quarks with hierarchical Yukawa couplings involving b and s quarks. At the same time, it can easily satisfy other flavour physics constraints. Direct detection searches utilizing the Migdal effect constrain some of the parameter space.

Polygonatum hunanense H.H. Liu & B.Z. Wang (2021) and P. verticillatum (L.) All. (1875) have been widely used as foods and as folk medicines in China and India, and P. caulialatum S. R. Yi (2021) has recently been described as a new medical plant in China. There is at present a lack of genome information regarding the species. Hence, this study reports the complete chloroplast genomes of the three species. The genomes of P. hunanense, P. verticillatum, and P. caulialatum were 155,583 bp, 155,650 bp, and 155,352 bp in length, respectively. They contained large single-copy (LSC) regions of 84,412 bp, 84,404 bp, and 84,285 bp, small single-copy (SSC) regions of 18,427 bp, 18,416 bp, and 18,463 bp, and a pair of inverted repeats of 26,372 bp, 26,415 bp, and 26,302 bp, respectively. The chloroplast genomes of P. hunanense, P. verticillatum, and P. caulialatum had 133 (103 unique) genes, consisting of 87 protein-coding genes, 38 ribosomal ribonucleic acid (RNA) genes, and eight transfer RNA genes, respectively. A maximum-likelihood phylogenetic tree showed that P. kingianum Coll. et Hemsl. var. grandifolium D.M. Liu & W.Z. Zeng (1991) was closer to P. cyrtonema Hua (1892) rather than to P. kingianum Coll. et Hemsl. (1890), further supporting its status as a unique species of the genus. Moreover, P. verticillatum was separated from the easily confused herb P. cirrhifolium (Wall.) Royle (1839), while P. caulialatum was closest to P. humile Fisch. ex Maxim. (1859). This research provides a foundation for further study of these herbs.

Abstract Background Esophageal cancer, a global health concern, impacts predominantly men, particularly in Eastern Asia. Lymph node metastasis (LNM) significantly influences prognosis, and current imaging methods exhibit limitations in accurate detection. The integration of radiomics, an artificial intelligence (AI) driven approach in medical imaging, offers a transformative potential. This meta-analysis evaluates existing evidence on the accuracy of radiomics models for predicting LNM in esophageal cancer. Methods We conducted a systematic review following PRISMA 2020 guidelines, searching Embase, PubMed, and Web of Science for English-language studies up to November 16, 2023. Inclusion criteria focused on preoperatively diagnosed esophageal cancer patients with radiomics predicting LNM before treatment. Exclusion criteria were applied, including non-English studies and those lacking sufficient data or separate validation cohorts. Data extraction encompassed study characteristics and radiomics technical details. Quality assessment employed modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) and Radiomics Quality Score (RQS) tools. Statistical analysis involved random-effects models for pooled sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC). Heterogeneity and publication bias were assessed using Deek’s test and funnel plots. Analysis was performed using Stata version 17.0 and meta-DiSc. Results Out of 426 initially identified citations, nine studies met inclusion criteria, encompassing 719 patients. These retrospective studies utilized CT, PET, and MRI imaging modalities, predominantly conducted in China. Two studies employed deep learning-based radiomics. Quality assessment revealed acceptable QUADAS-2 scores. RQS scores ranged from 9 to 14, averaging 12.78. The diagnostic meta-analysis yielded a pooled sensitivity, specificity, and AUC of 0.72, 0.76, and 0.74, respectively, representing fair diagnostic performance. Meta-regression identified the use of combined models as a significant contributor to heterogeneity (p-value = 0.05). Other factors, such as sample size (> 75) and least absolute shrinkage and selection operator (LASSO) usage for feature extraction, showed potential influence but lacked statistical significance (0.05

The objective of this paper is to propose a novel approach to develop an algorithm for estimating the grounding force between a tyre and the road surface. First, a finite element model of a heavy-duty tyre is developed in this paper, and the validity of the model is verified by load application tests and mechanical vibration tests. When the tyres are operated under various operating conditions, that is, load, side deflection, side tilt and longitudinal slip conditions, the sensitivity analysis is performed by combining the three-directional forces based on the strain curves measured when the tyres are rolling, respectively. In order to achieve accurate estimation of the three-directional forces, this paper establishes a three-directional force estimation model using the support vector machine (SVM) technique, with the tyre force-sensitive eigenvalues as inputs and the tyre forces as outputs, so as to achieve the three-directional force estimation of the tyre-grounded three-directional forces. joint estimation of tyre-road contact force. The results show that the estimation error of vertical force is 1.79%, the estimation error of lateral force is 3%, the estimation error of longitudinal force is 4.65% and in general, the estimation error of grounding force is kept within 5%, and the estimation effect is good.

Sewage with a low carbon-to-nitrogen (C/N) ratio can be effectively treated using high-rate algal ponds (HRAPs), consisting of a combined symbiotic system of algae and bacteria. However, HRAPs have been predominantly used in laboratories, but their application in wastewater treatment plants is yet to be realized. Herein, laboratory and pilot-scale experimental studies were conducted using wetland effluent from the Baitabao estuary and effluent from the ecological wastewater treatment plant in Liaozhong County. The ammonia nitrogen (NH4+–N) and chemical oxygen demand (COD) concentrations in the effluent treated using the lab-scale system decreased to

Abstract Background Neuronal ferroptosis plays a critical role in the pathogenesis of cognitive deficits. The present study explored whether artemisinin protected type 2 diabetes mellitus (T2DM) mice from cognitive impairments by attenuating neuronal ferroptosis in the hippocampal CA1 region. Methods STZ-induced T2DM mice were treated with artemisinin (40 mg/kg, i.p.), or cotreated with artemisinin and Nrf2 inhibitor MEL385 or ferroptosis inducer erastin for 4 weeks. Cognitive performance was determined by the Morris water maze and Y maze tests. Hippocampal ROS, MDA, GSH, and Fe2+ contents were detected by assay kits. Nrf2, p-Nrf2, HO-1, and GPX4 proteins in hippocampal CA1 were assessed by Western blotting. Hippocampal neuron injury and mitochondrial morphology were observed using H&E staining and a transmission electron microscope, respectively. Results Artemisinin reversed diabetic cognitive impairments, decreased the concentrations of ROS, MDA and Fe2+, and increased the levels of p-Nr2, HO-1, GPX4 and GSH. Moreover, artemisinin alleviated neuronal loss and ferroptosis in the hippocampal CA1 region. However, these neuroprotective effects of artemisinin were abolished by Nrf2 inhibitor ML385 and ferroptosis inducer erastin. Conclusion Artemisinin effectively ameliorates neuropathological changes and learning and memory decline in T2DM mice; the underlying mechanism involves the activation of Nrf2 to inhibit neuronal ferroptosis in the hippocampus. Graphical Abstract

Abstract Background Atrial fibrillation (AF) is a prevalent arrhythmic condition resulting in increased stroke risk and is associated with high mortality. Electrolyte imbalance can increase the risk of AF, where the relationship between AF and serum electrolytes remains unclear. Methods A total of 15,792 individuals were included in the observational study, with incident AF ascertainment in the Atherosclerosis Risk in Communities (ARIC) study. The Cox regression models were applied to calculate the hazard ratio (HR) and 95% confidence interval (CI) for AF based on different serum electrolyte levels. Mendelian randomization (MR) analyses were performed to examine the causal association. Results In observational study, after a median 19.7 years of follow-up, a total of 2551 developed AF. After full adjustment, participants with serum potassium below the 5th percentile had a higher risk of AF relative to participants in the middle quintile. Serum magnesium was also inversely associated with the risk of AF. An increased incidence of AF was identified in individuals with higher serum phosphate percentiles. Serum calcium levels were not related to AF risk. Moreover, MR analysis indicated that genetically predicted serum electrolyte levels were not causally associated with AF risk. The odds ratio for AF were 0.999 for potassium, 1.044 for magnesium, 0.728 for phosphate, and 0.979 for calcium, respectively. Conclusions Serum electrolyte disorders such as hypokalemia, hypomagnesemia and hyperphosphatemia were associated with an increased risk of AF and may also serve to be prognostic factors. However, the present study did not support serum electrolytes as causal mediators for AF development.

Androgenetic alopecia (AGA) is a common clinical condition, affecting over 200 million people globally each year. For decades, Minoxidil (Mi) tincture has been the primary treatment for this disease, but its low utilization rate and significant side effects necessitate new therapeutic strategies. Nitric oxide (NO) is a signaling molecule in various physiological processes, including vasodilation, immune responses, and cell proliferation. Herein, we constructed a hyaluronic acid liposome (HL) complex as a novel transdermal delivery system (HL@Mi/NONOate) for NO and Mi, which displayed promising transdermal and hair-regrowth effects. In-depth mechanistic studies revealed three potential pathways of the synergistic AGA therapy. First, NO promoted capillary dilation and accelerated blood flow, thus achieving efficient penetration of Mi. Due to the structural advantage of liposomes, the residence time of the Mi in the skin was prolonged. Moreover, HL@Mi/NONOate promoted cell proliferation and angiogenesis, and upregulated the expression of regulatory factors involved in follicle stem cell differentiation. In the AGA model, HL@Mi/NONOate down-regulated the expression of inflammatory factors, inhibiting the inflammation of follicle and improving the microenvironment of hair regrowth. Concurrently, HL@Mi/NONOate upregulated the expression of Ki67 and PCNA proteins in follicle tissues, inducing follicle regeneration and development, ultimately achieving the synergistic multimodal AGA therapy.

This research aims to assess the massif vibration that results from hydraulic transitions of pumped storage power plant (PSPP) and probe into their consequences on mountain stability. Firstly, numerical simulations of the hydraulic transitions in a pumped storage power plant were carried out, and the pressure pulsations within different sections of the waterway system under pumping and generating conditions were obtained. The historical pressure during the hydraulic transients was used as the dynamic loading condition for transient structural analysis. The time-history curves of horizontal and vertical accelerations were obtained for four main working conditions, and four detection areas were demarcated on the massif surface for analysis. The results showed that the maximum amplitude of horizontal acceleration occurred within the height range of 760 m to 960 m of work condition T2. Statistical methods and one-third octave analysis were further applied to analyze the acceleration time-history curves, showing that the highest vibration levels in the horizontal direction were observed at a specific frequency of 50 Hz. This study indicates that the hydraulic transition process of pumped-storage power stations will have a significant impact on massif stability; therefore, it is crucial to consider corresponding seismic mitigation measures during the design and operating stages to ensure structural safety.

Identifying indicators of non-functional overreaching during periods of increased training volume and/or intensity is particularly relevant for understanding the detrimental impacts incurred, as well as how these factors contribute to heightened injury risks among exposed athletes. This study aimed to compare the effects of a congested training period versus a standard training period on the strength levels and landing forces of female young aerobic gymnastics athletes. A prospective cohort study design was implemented, spanning four weeks. Fifty athletes (aged 16.2 ± 1.1 years old) at a trained/developmental level, competing at the regional level, were observed throughout the study. During two of these weeks (specifically weeks 2 and 3), half of the group was subjected to a congested training period consisting of six sessions per week (HTF), while the other half continued with their regular four sessions per week (STF). During each week of observation, participants underwent evaluation using the countermovement jump test (CMJ), squat jump test (SJ), and the leg land and hold test (LHT), with measurements taken on a force platform. The main outcomes repeatedly observed over the four weeks were CMJ peak landing force, CMJ peak power, SJ peak power, SJ maximum negative displacement, LHT time to stabilization, and LHT peak drop landing force. Significant interactions (time*group) were observed in CMJ peak power (p

By analyzing the deficiencies of existing hydraulic erecting systems (HESs) control methods, this study proposes a linear time-varying model predictive control (LTV-MPC) method based on the linear extended state observer (LESO) for HESs. First, the working mechanism of HESs is methodically analyzed and the corresponding state space equations are established. Second, the LESO system is designed to estimate the current unknown real-time states. Then, the LTV-MPC is employed to evaluate and output the optimal solution of the servo voltage signal. Finally, through simulation and experiment, the effectiveness of the proposed method is confirmed and discussed. The results show that the displacement error rate of the proposed method is still lower than 0.223% under larger external disturbances, which can effectively improve the control accuracy and stability of the system compared with other methods.

Abstract The coupling electrosynthesis involving CO2 upgrade conversion is of great significance for the sustainable development of the environment and energy but is challenging. Herein, we exquisitely constructed the self‐supported bimetallic array superstructures from the Cu(OH)2 array architecture precursor, which can enable high‐performance coupling electrosynthesis of formate and adipate at the anode and the cathode, respectively. Concretely, the faradaic efficiencies (FEs) of CO2‐to‐formate and cyclohexanone‐to‐adipate conversion simultaneously exceed 90% at both electrodes with excellent stabilities. Such high‐performance coupling electrosynthesis is highly correlated with the porous nanosheet array superstructure of CuBi alloy as the cathode and the nanosheet‐on‐nanowire array superstructure of CuNi hydroxide as the anode. Moreover, compared to the conventional electrolysis process, the cell voltage is substantially reduced while maintaining the electrocatalytic performance for coupling electrosynthesis in the two‐electrode electrolyzer with the maximal FEformate and FEadipate up to 94.2% and 93.1%, respectively. The experimental results further demonstrate that the bimetal composition modulates the local electronic structures, promoting the reactions toward the target products. Prospectively, our work proposes an instructive strategy for constructing adaptive self‐supported superstructures to achieve efficient coupling electrosynthesis.

Summary: Background: Biliary atresia (BA) is a neonatal fibro-inflammatory cholangiopathy with ductular reaction as a key pathogenic feature predicting poor survival. Mucosal-associated invariant T (MAIT) cells are enriched in human liver and display multiple roles in liver diseases. We aimed to investigate the function of MAIT cells in BA. Methods: First, we analyzed correlations between liver MAIT cell and clinical parameters (survival, alanine transaminase, bilirubin, histological inflammation and fibrosis) in two public cohorts of patients with BA (US and China). Kaplan–Meier survival analysis and spearman correlation analysis were employed for survival data and other clinical parameters, respectively. Next, we obtained liver samples or peripheral blood from BA and control patients for bulk RNA sequencing, flow cytometry analysis, immunostaning and functional experiments of MAIT cells. Finally, we established two in vitro co-culture systems, one is the rhesus rotavirus (RRV) infected co-culture system to model immune dysfunction of human BA which was validated by single cell RNA sequencing and the other is a multicellular system composed of biliary organoids, LX-2 and MAIT cells to evaluate the role of MAIT cells on ductular reaction. Findings: Liver MAIT cells in BA were positively associated with low survival and ductular reaction. Moreover, liver MAIT cells were activated, exhibited a wound healing signature and highly expressed growth factor Amphiregulin (AREG) in a T cell receptor (TCR)-dependent manner. Antagonism of AREG abrogated the proliferative effect of BA MAIT cells on both cholangiocytes and biliary organoids. A RRV infected co-culture system, recapitulated immune dysfunction of human BA, disclosed that RRV-primed MAIT cells promoted cholangiocyte proliferation via AREG, and further induced inflammation and fibrosis in the multicellular system. Interpretation: MAIT cells exhibit a wound healing signature depending on TCR signaling and promote ductular reaction via AREG, which is associated with advanced fibrosis and predictive of low survival in BA. Funding: This work was funded by National Natural Science Foundation of China grant (82001589 and 92168108), National Key R&D Program of China (2023YFA1801600) and by Basic and Applied Basic Research Foundation of Guangdong (2020A1515110921).

In recent years, explosion shock wave has been considered as a signature injury of the current military conflicts. Although strong shock wave is lethal to the human body, weak shock wave can cause many more lasting consequences. To investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading, the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3 (F-200) and 400.0 kg/m3 (F-400), polyurea with the density of 1100.0 kg/m3 (P-1100) and structures composed of the two materials, which are intended for individual protection. Experimental results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not damaged. The shock wave protective capability of single-layer materials is dependent on their thickness, density and microscopic characteristics. The overpressure, maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample thickness. For the same thickness, F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three materials. In this study, as the materials are not destroyed, F-200 with a thickness more than 10.0 mm, F-400 with a thickness more than 4.0 mm, and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%. Further, multi-layer flexible composites are designed. Different layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective performance. Within the research range, the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance, and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm respectively. The overpressure attenuation rate reached maximum value of 93.3% and impulse attenuation capacity of this structure are better than those of single-layer polyurea and polyurethane foam with higher areal density.

Abstract We introduce the effective field theory of two different light dark particles interacting with the standard model (SM) light states in a single vertex, termed dark sector effective field theory (DSEFT). We focus on the new light particles with spin up to 1 and being real in essence, namely, new real scalars ϕ and S, Majorana fermions χ and ψ, and real vectors X μ and V μ . In the framework of low energy effective field theory with QED and QCD symmetry, the DSEFT can be classified into six categories, including the scalar-scalar-SM (ϕS-SM), fermion-fermion-SM (χψ-SM), vector-vector-SM (XV-SM), scalar-fermion-SM (ϕχ-SM), scalar-vector-SM (ϕX-SM), and fermion-vector-SM (χX-SM) cases. For each case, we construct the effective operator basis up to canonical dimension 7, which will cover most interesting phenomenology at low energy. As a phenomenological example, we investigate the longstanding neutron lifetime anomaly through the neutron dark decay modes n → χϕ or χX from the effective interactions in the fermion-scalar-SM or fermion-vector-SM case. When treating the light fermion as a dark matter candidate, we also explore the constraints from DM-neutron annihilation signal at Super-Kamiokande. We find the neutron dark decay in each scenario can accommodate the anomaly, at the same time, without contradicting with the Super-Kamiokande limit.

Strength-ductility trade-off is a common issue in Mg alloys. This work proposed that a synergistic enhancement of strength and ductility could be achieved through tuning interlayer dwell time (IDT) in the wire and arc additive manufacturing (WAAM) process of Mg alloy. The thermal couples were used to monitor the thermal history during the WAAM process. Additionally, the effect of different IDTs on the microstructure characteristics and resultant mechanical properties of WAAM-processed Mg alloy thin-wall were investigated. The results showed that the stable temperature of the thin-wall component could reach 290 °C at IDT=0s, indicating that the thermal accumulation effect was remarkable. Consequently, unimodal coarse grains with an average size of 39.6 µm were generated, and the resultant room-temperature tensile property was poor. With the IDT extended to 60s, the thermal input and thermal dissipation reached a balance, and the stable temperature was only 170 °C, closing to the initial temperature of the substrate. A refined grain structure with bimodal size distribution was obtained. The remelting zone had fine grains with the size of 15.2 µm, while the arc zone owned coarse grains with the size of 24.5 µm. The alternatively distributed coarse and fine grains lead to the elimination of strength-ductility trade-off. The ultimate tensile strength and elongation of the samples at IDT=60s are increased by 20.6 and 75.0% of those samples at IDT=0s, respectively. The findings will facilitate the development of additive manufacturing processes for advanced Mg alloys.

We introduce a generalized concept of arbitrage, excess profit relative to the benchmark asset under $ \alpha $-confidence level, $ \alpha $-REP, in a single-period market model with proportional transaction costs. We obtain a fundamental theorem of asset pricing with respect to the absence of $ \alpha $-REP. Moreover, we discuss the relationships between classical arbitrage, strong statistical arbitrage and $ \alpha $-REP.

A novel shear thickening gel with micro-scale hard/soft interface structure and low reaction temperature was proposed in this article. The gel was named TH and used as core material within Kevlar fabrics. Storage modulus of TH was proved to increase by around two orders with increasing of shear frequency, and dynamic properties indicated that TH could dissipate or store more energy. TH can adhere with Kevlar fabrics well and satisfactorily fulfill the gap between fabrics. As a result, shock wave peak pressure and positive impulse decreased markedly. Wavelet decomposition analysis show that high frequency energy was filtered by protection materials. Meanwhile, impact resistance test suggested the existence of TH changed the stress propagation routes and avoided pulling out for Kevlar fabrics. Samples filled with TH demonstrated a better shock wave mitigation ability and impact resistance. Energy dissipation structures with TH have a promising prospect in the application of defending area.

Wire arc additive manufacturing (WAAM) of Mg-RE (rare-earth)-Zn alloys is important for meeting the requirements of lightweight large-scale components with high manufacturing flexibility. The Mg-8.1Gd-2.6Y-0.7Zn-0.5Zr (GWZ831K, wt.%) alloys were fabricated through the use of WAAM technology, and the microstructure evolution along the building direction and corresponding mechanical properties were then studied. The as-built sample in this paper was composed of finely equiaxed ɑ-Mg grains, eutectic (Mg, Zn)3(Gd, Y) phase, cubic phase, and γʹ precipitates. Furthermore, due to the in-suit heat treatments that were induced by the multiple thermal cycles, more γʹ precipitates were observed in the middle region. The microstructures at different heights were characterized by alternatively distributed fine equiaxed grains (melt pool boundaries, MPB) and coarse equiaxed grains (melt pools, MP). The mechanical properties of the as-built component were found to exhibit yield strength (YS), ultimate tensile strength (UTS), and elongation (EL) of 159 ± 1.0 MPa, 237 ± 4.0 MPa, and 6.7 ± 0.4 % in the building direction (BD) and 163 ± 5.1 MPa, 242 ± 8.7 MPa, and 7.0 ± 0.7 % in the traveling direction (TD). This demonstrates that the WAAM-processed GWZ831K alloy has good isotropy.

Abstract Fermionic dark matter can be pairly produced and hence searched with missing energy at colliders. We extend such probe to the associated production of a neutrino and a dark sector fermion at the future e + e − colliders such as CEPC, FCC-ee, ILC, and CLIC. Two typical processes, the mono-photon and electron-positron pair productions associated with missing energy, can serve the purpose. While the mono-photon search prevails at CEPC, FCC-ee, and ILC, the channel has more significant contributions at CLIC with much higher collision energy s $$ \sqrt{s} $$ . The beam polarizations can help further suppressing the SM backgrounds to enhance the signal significance while differential cross sections can distinguish the Lorentz structure of various effective operators. The combined sensitivity can reach well above 1 TeV at CEPC/FCC-ee and ILC while it further touches 30 TeV at CLIC. Comparing with the updated results from the direct detection experiments (XENON1T, PandaX-II, PandaX-4T, LZ, and XENONnT), astrophysical X/γ-ray observations, and cosmological constraints for the sub-MeV absorption dark matter, the collider searches are actually more sensitive and hence can provide a complementary approach to addressing the dark fermions.

Combustible gases, such as CO, CH4, and H2, are produced during spontaneous coal combustion in goaf, which may cause an explosion under the stimulation of an external fire source. It is of great significance to study the influence of combustible gases, such as CO and H2, on the characteristics of a gas explosion. In this study, CHEMKIN software (Version 17.0) and the GRI-Mech 3.0 reaction mechanism were used to study the influences of different concentration ratios between CO and H2 on the ignition delay time, free radical concentration, and key reaction step of a gas explosion. The results show that the increase in the initial CH4 and CO concentrations prolonged the ignition delay time, while the increase in the H2 concentration shortened the time and accelerated the explosion reaction. The addition of H2 promoted the generation of free radicals (H·, O·, ·OH) and accelerated the occurrence of the gas explosion. CO generated ·OH free radicals and dominated the methane consumption through the R119 and R156 reactions. As the concentrations of CO and H2 increased, the R38 reaction gradually became the main driving factor of the gas explosion.

CO, H2, and other combustible gases will be produced during coal oxidation in coal mines, which will increase the risk of explosion when mixed with methane. Therefore, it is very important to understand the production characteristics of combustible gas during coal oxidation. In this paper, a programmed temperature gas test system is built to study the impact of lignite on the production of gases at different particle sizes and temperatures, and the release characteristics of gases are also analyzed. The result shows that the production of combustible gas is influenced by the coal particle size significantly when the temperature is above 200 °C, and it decreases as the particle size increases. CO is the main gas during the early stage of coal spontaneous combustion, and the release of CH4 and H2 increases after 300 °C. The fitted equations of gas generation and temperature are consistent with the experimental results. The research results are helpful in understanding the hazards of coal spontaneous combustion and have a certain guiding significance for coal mine monitoring and prevention of coal spontaneous combustion.

The widespread use of per- and polyfluoroalkyl substances (PFASs) with different physico–chemical properties poses a great threat to the environment and human health. Simultaneous detection of different classes of PFASs is a difficult task, especially for rapid analysis of polluted water samples in environmental forensic cases. In this study, a simple sample preparation ultrahigh-performance liquid chromatography coupled with quadrupole Orbitrap high-resolution mass spectrometry was established for the detection of PFASs in a wide range of water matrices. By optimizing the conditions of pretreatment and the parameters of the instrument, the developed method provided good linearity of calibration standards (R2 > 0.99), and demonstrated excellent MLOQ (0.008–1.2 µg/L), with spiked recoveries ranging from 57.7% to 151% for 47 targets in surface water samples, and from 45.7 to 165% for 46 targets in ground and waste water samples, respectively. This method required an injection volume of 3 µL and an analysis time of only 18 min per sample. The validation method was successfully applied to the analysis of 20 environmental water samples, in which 15 target substances with different concentrations were detected, with total concentrations of 0.082 to 262.455 μg/L. The method is simple and exclusive, and can rapidly confirm the occurrence of PFASs in different water samples, providing a convenient and fast high-throughput analysis, which is especially suitable for the application in the environmental forensic investigation of PFASs pollution.

Objective: To investigate the community integration of patients following stroke and determine the predictors of their level of community integration at 1-year follow-up. Design: A multicenter, longitudinal, and observational study. Subjects: Sixty-five inpatients (41 men) with a mean age of 56.9 (standard deviation = 17.0) years, who had their first stroke at least 1 month prior to this study were recruited from 4 rehabilitation inpatient wards in China. Methods: In the initial assessment, the participants were evaluated using the Community Integration Questionnaire, the Fugl-Meyer Assessment, the Berg Balance Scale, the Modified Barthel Index, the Mini Mental State Examination, and the Modified Ashworth Scale. In the follow-up assessments, which were conducted via telephone no less than 1 year after discharge, the participants were evaluated using the Community Integration Questionnaire and also assessed for other disease-related conditions. Results: The participants’ scores on the Community Integration Questionnaire in the follow-up assessment were significantly greater than those at the initial assessment (p

Objective: Acute aortic dissection (AAD) with a high mortality and postoperative complications remains presently no effective indicators to conjunctly predict the short-term mortality and the prognosis. This study aimed to investigate the predictive role of α-HBDH on in-hospital mortality and postoperative Major adverse cardiovascular events (MACE) in patients with AAD. Methods: In this retrospective study, a total of 369 enrolled patients from 2015 to 2021 were divided into three groups (T1: low, T2: medium and T3: high) based on the tertiles of α-HBDH levels on admission. In terms of the preoperative, intraoperative and postoperative indicators among 3 groups, the relationship between α-HBDH and studying endpoints was determined by logistic regression models, along with the consolidation using Kaplan–Meier and restricted cubic spline (RCS) analysis for predicting the in-hospital death and MACE complications. Last, subgroup analysis further verified the predictive value of α-HBDH. Results: Logistic regression analysis showed that α-HBDH was independently associated with in-hospital mortality of patients with AAD [OR(95CI): 4.771(1.043–21.832), P = 0.044] and MACE [OR(95CI): 9.869(2.148–45.349), P = 0.003]. Moreover, Kaplan-Meier analysis also showed an increased α-HBDH levels associated with poor survival within 30 days (log rank test, P 0.05). Conclusions: α-HBDH is a predictor of the in-hospital mortality and postoperative MACE, guiding admission stratification of patients with AAD.

Purpose: This study aimed to: (i) analyze the changes in physical fitness and body composition following a 4-month intervention of small-sided games (SSG) training; and (ii) analyze the association between internal and external training loads and the observed changes in physical fitness and body composition among sedentary young adults. Methods: Sixty sedentary individuals (males: 30; females: 30) participated in this randomized controlled trial study. Physical fitness and body composition parameters were assessed at the 1st, 8th weeks, and 16th weeks after a SSG intervention. Results: Significant main effects of time and gender on overall physical fitness parameters, with a notable time-group interaction were observed. For body composition measures, we found significant main effects of time, group, and gender. Furthermore, we identified significant correlations between shuttle run, handgrip, and vertical jump performance, and the time spent at VO2max (TVO2max) during SSG (r = −0.779, p = 0.001; r = −0.788, p = 0.001; r = 0.692, p = 0.004, respectively). Handgrip strength exhibited significant correlations with heat exhaustion (HE) and total distance (TD) during SSG (r = −0.616, p = 0.014; r = −0.629, p = 0.012). Similarly, we observed significant correlations between hip perimeter (HP), skinfolds (SF), waist-to-hip ratio (W:H), and TVO2max (r = 0.624, p = 0.013; r = 0.663, p = 0.007; r = 0.535, p = 0.040, respectively). Conclusion: This study indicates that the intensity achieved during SSG plays a crucial role in fostering positive adaptations in aerobic capacity, maximal strength, and jumping performance in recreational soccer. Therefore, practitioners should ensure that SSG formats generate the required stimulus to sustain prolonged periods within VO2max zones.