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The 5α,6-dihydro congeners of veragranines A and B, two steroidal alkaloids with an unprecedented hexacyclic skeleton and potent analgesic effects, were synthesized from hecogenin acetate within six steps. This work enables quick access to the hexacyclic skeleton and is amendable to prepare other D-ring-modified congeners.

The aim of the present study was to investigate the protective effects of Shenfu injection (SFI) against myocardial ischemia-reperfusion injury (MIRI) in model rats and to explore its mechanism of action. Sprague-Dawley (SD) rats were pretreated with SFI and N

To investigate the role of TIGIT signal in Th1/Th2 balance in the process ofMale C57BL/6 mice were infected with cercariae ofThe proportion of TIGITThe TIGIT signaling may be involved in the development of Th2 responses in the mice infected with[

To assess the influence of glycolytic pathway on the proportion and numbers of regulatory T cells duringAThe proportions of Glut1Glycolytic pathway inhibits Treg differentiation in the spleen and mesenteric LNs of[

To study the influence of sex on the generation and function of T follicular helper (Tfh) cells in the process ofTotally 50 schistosomiasis patients were selected in the endemic areas of Chizhou City, Anhui Province, and totally 50 healthy people were selected in the non-endemic areas of Chizhou City as the controls. The peripheral bloods were collected from the above study subjects, and the human peripheral blood mononuclear cells from male/female schistosomiasis japonica patients or healthy controls were collected into the sodium heparin tubes and purified by Ficoll-paque plus density gradient centrifugation. Then, the percentages of total Tfh cell, ICOSCompared with the male and female healthy controls, the frequency of the total Tfh cells (Sex may be a crucial role in the generation and function of Tfh cells in the process of［

A two-dimensional flow numerical model of the tidal reaches, which total length is more than 700 km, is established from Datong to the Yangtze River estuary. The tidal levels, velocities, diversion ratios and dynamic axes before and after the separate regulation of each reach and combined regulation of all reaches are obtained. The comparative analysis shows that the regulation project of a separate reach basically has no impact on velocity distributions and variations of diversion ratios of upper and lower reaches, the variations of dynamic axes are only within the local scope of the project. The regulation project of a separate reach also has less impact on the water level in the lower adjacent reaches, but will make the water levels in the upper reaches rise. After the implementation of the regulation projects for all reaches, the rise of water level in the upstream reaches will have a cumulative impact.

This paper studied the management and monitoring graduation-designing platform of the university undergraduate based on the internet technology. Practice has proved that the platform can let the students write graduation-designing journal of the electronic version at any place at any time; It can update their completion status of the graduation designing in real time; Teachers in the colleges and universities can land the platform and gave the answers to the students questions in time with a variety of ways. It truly achieved the new 4W comprehensively monitoring and management pattern that some "cage-free" serious professional students of the graduation designing, especially represented by the IT professional students.

On the basis of researching virtual reality training system at home and abroad, in view of the oilfield staff training needs, we design the training system framework of the oilfield staff simulation based on virtual reality technology. Give the composition of the system framework and the main functions of the modules. Using the simulation technology, we can draw the craft process. Let the employees do man-machine interactive operation in a virtual reality scene. Then according to the quality of operation, operation steps and the alarm-condition appears in the operation, the training system give a score. Through this kind of training methods, it improves the safety skills of the oilfield staff and capability of dealing with accidents.

This thesis summarized the content of IOCP( I/O completion port ). It was improved in connection with the defect that is data communications more occupation on server system resources and its poor parallel processing ability, in the original on-line automatic-monitoring platform. It improved the shortcomings of the original data communication through the package IOCP model. And we launched an exploratory study about the package IOCP model.

Paper illustrates the background of boutique open video class in China. According to the prepared works of the photographers and the subjects before we taped of the boutique open video classes in the teaching field of China, it researches the techniques which are used in recording video and later editing. It mainly discusses the problems, such as one third composition methods, cutting-body principle, lens push-pull shooting technologies and the photography technology problems and so on. It also studies the forming strategy of the online open classes initiated by foreign distinguished universities.

This paper introduces the concept and function of the Scalable Vector Graphics (SVG). According to the basic principles of the drawing palisade connected graph, the method of drawing the palisade connected graph is finally achieved in consideration of such key technologies as the number and connection of the layers, as well as how to eliminate the hidden lines, and by employing the water injection wells data. Furthermore, it also shows how to realize the zooming and dragging of the palisade connected graph through the SVG technology. Ultimately, combined with the data background of Daqing No.2 Oil Plant water injection wells, this article illustrates the implemented effect of the palisade map.

The paper illustrates the background of boutique open video class in China, and the differences between the boutique open video class and the boutique shared class. It also discusses the domestic study of the strategy of forming the online open courses initiated by foreign distinguished universities in recent years. By the comparison of the strategy used at home and abroad in terms of equipment, shooting techniques, and multimedia technology utilization, it draws the revelation of producing boutique video open classes.

The pathogenicity of a field isolate of Marek's disease virus (MDV) named GXY2 integrated with retroviral long terminal repeat (LTR) sequence from a chicken with MD tumors was evaluated. Experimental chickens were divided into group A, B, C, D and E. The later four groups were vaccinated on one-day-old with CVI988/Rispens for group B and D, with HVT for group C and E, while group A was taken as no-vaccinated control. On 8-day-old, group A, B and C were challenged with GXY2 by intra-abdominal injection, group D and E were kept as un-challenged control. All the birds were raised routinely until 82 days post-challenge (PC), died birds during the experiment and the slaughtered birds at the end of the experiment were necropsied and examined for gross lesions of MD and further confirmed by a developed polymerase chain reaction (PCR) based differential diagnosis technique for avian neoplastic diseases. The results showed that time of onset of MD death of group A, B and C were PC 25, 77 and 29 days with the incidences of visible MD visceral tumors. On PC 82 days, tumor incidences and mortalities of group A, B and C were 72%, 34.8% and 50%, 84%, 21.7% and 20%, respectively. The vaccination protection of CVI988/Rispense and HVT were 51.67% and 30.56% respectively. Among all the visceral organs, heart had the highest tumor incidences (23.5%), and then followed by liver (14.7%) and gizzard (10.3%). The weight-gain of unvaccinated birds was significantly depressed and severe dystrophy of thymus and bursa of Fabricius were also found. The results of the study demonstrated that isolate GXY2 possessed the ability of causing acute tumors and overcoming the protection of the vaccinations of either CVI988/Rispense or HVT.

To prepare the compound danshen pH-dependent delayed release pellets and filled them in capsules and then study thier pharmacodynamics.The pH-dependent delayed release pellets were prepared by coating with HPMC, Eudragit L-30D-55 and Eudragit L100-Eudragit S100 (1:6), separately, and mixed in proper proportion to prepare the two pH-dependent delayed release systems T1 and T2. The release of delayed release pellets was determined according to the method of China Pharmacopoeia (2000) in the simulated gastrointestinal pH conditions. The pharmacodynamic,parameters were evaluated by serum pharmacology method.The compound danshen pH-dependent delayed release pellets were prepared with the characteristics of pH dependent delayed release profile in vitro. In single oral dose, the pharmacodynamic parameters of rapid release tablets R Emax (%) and Tmax (h) were 34.63% and 0.58 h, respectively. Tmax S of delayed-release pellets T1 and T2 were extended to 2.42, 3.17 h and Emax S (%) were declined to 13.57%, 14.52%. The relative bioavailabilities of T1 and T2 were 99.3%, 133.6% , respectively. In multiple oral doses of R the pharmacodynamic parameter of DF was 7.32 and those T1, T2 DF were 3.40, 3.03, respectively.The compound danshen pH-dependent delayed release capsules have characteristics of pH dependent releasing in vitro and characteristics of delayed release in vivo. In multiple oral (loses the DF of delayed release capsules was lower than that of rapid release tablet at steady state.

Pulse coding and pulse compression techniques have been used extensively in radar, sonar, non-destructive testing and seismic imaging1-4. Its application in medical imaging has been sparse and few5-8,. Possible reasons could be, (i) limitations on timebandwidth product5,7 due to transducers operating in 1 to 10 MHz range with only 60% fractional bandwidth, (ii) frequency dependent attenuation in soft tissue5 and (iii) a need to keep the sidelobe levels that result from pulse compression processing below certain levels7, for improved contrast resolution. With significant improvements in processing hardware and software, real time implementation does not appear to be a significant problem7,10. In this paper we have examined two possible applications of pulse coding techniques. The possibility of increasing the effective bandwidth of a transducer (and hence the time-bandwidth product) through pre-enhancement of the drive signal has been evaluated with simulation studies. The increasing penalty on the sidelobe levels is also examined. As a second application, the flexibility to change the center frequency f 0 and bandwidth Δf of the coded signal has been exploited to study experimentally the subresolution scattering microstructure of a scattering object.