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Your search keyword '"Dong, Jia-Mei"' showing total 12 results
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12 results on '"Dong, Jia-Mei"'

2. Study of the pseudoscalar glueball in $J/\psi$ radiative decays

Author

Gui, Long-Cheng, Dong, Jia-Mei, Chen, Ying, and Yang, Yi-Bo

Subjects
High Energy Physics - Lattice, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We aim to explore the production rate of the pseudoscalar glueball in $J/\psi$ radiative decay by lattice QCD in quenched approximation. The calculation is performed on three anisotropic lattices with the spatial lattice spacing ranging from 0.222(2) fm to 0.110(1) fm. As a calibration of some systematical uncertainties, we first extract the $M1$ form factor $\hat{V}(0)$ of the process $J/\psi\to\gamma\eta_{c}$ and get the result $\hat{V}(0)=1.933(41)$ in the continuum limit, which gives the partial width $\Gamma(J/\psi\to\gamma\eta_{c})=2.47(11)$ keV. These results are in agreement with that of previous lattice studies. As for the pseudoscalar glueball $G_{0^{-+}}$, its mass is derived to be $2.395(14)$ GeV, and the form factor $\hat{V}(0)$ of the process $J/\psi\to\gamma G_{0^{-+}}$ is determined to be $\hat{V}(0)=0.0246(43)$ after continuum extrapolation. Finally, the production rate of the pseudoscalar glueball is predicted to be $2.31(90)\times10^{-4}$, which is much smaller than that of conventional light $q\bar{q}$ $\eta$ states. After the subtraction of the phase space factor, the couplings of $J/\psi X\gamma$ are similar where $X$ stands for $\eta$ states and the pseudoscalar glueball. Possibly, the $U_{A}(1)$ anomaly plays an important role for the large couplings of gluons to the flavor singlet $\eta$ states in $J/\psi$ radiative decays., Comment: 11 pages, 16 figures, 7 tables, revised version. To appear in PRD

Published
2019
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4. Recent advances in optical aptasensors for biomarkers in early diagnosis and prognosis monitoring of hepatocellular carcinoma

Author

Dong, Jia-Mei, Wang, Rui-Qi, Yuan, Ning-Ning, Guo, Jia-Hao, Yu, Xin-Yang, Peng, Ang-Hui, Cai, Jia-Yi, Xue, Lei, Zhou, Zhi-Ling, Sun, Yi-Hao, and Chen, Ying-Yin

Subjects
Cell Biology, Developmental Biology
Abstract

Hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancers and is one of the main malignant tumor types globally. It is essential to develop rapid, ultrasensitive, and accurate strategies for the diagnosis and surveillance of HCC. In recent years, aptasensors have attracted particular attention owing to their high sensitivity, excellent selectivity, and low production costs. Optical analysis, as a potential analytical tool, offers the advantages of a wide range of targets, rapid response, and simple instrumentation. In this review, recent progress in several types of optical aptasensors for biomarkers in early diagnosis and prognosis monitoring of HCC is summarized. Furthermore, we evaluate the strengths and limitations of these sensors and discuss the challenges and future perspectives for their use in HCC diagnosis and surveillance.

Published
2023
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10. Identification of a genetic locus for autosomal dominant infantile cataract on chromosome 20p12.1-p11.23 in a Chinese family

Author

Zhang, Shirong, Liu, Mugen, Dong, Jia Mei, Yin, Ke, Wang, Pengyun, Bu, Juan, Li, Jing, Hao, Yan Sheng, Hao, Ping, Wang, Qing Kenneth, and Wang, Lejin

Subjects
Adult, Male, China, Adolescent, Chromosomes, Human, Pair 20, Middle Aged, eye diseases, Cataract, Pedigree, Corneal Opacity, Phenotype, Asian People, Humans, Family, Female, Lod Score, Child, Research Article, Genes, Dominant
Abstract

Purpose To map a gene responsible for infantile cataract in a large four-generation, non-consanguineous Chinese family. Methods Twenty-two family members including 17 cataract patients in the Chinese family were analyzed clinically. All family members were genotyped with 382 microsatellite markers that provide genome-wide coverage every 10 cM. Linkage analysis was performed to identify the chromosomal location of the infantile cataract gene in the family. Candidate genes were studied by direct DNA sequence analysis. Results Genome-wide linkage analysis provided evidence for a genetic locus for infantile cataract on chromosome 20p12.2-20p11.23. The maximum LOD score was 5.15 for marker D20S471 at a recombination fraction of 0. Fine mapping defined the cataract gene within a 7.4 Mb interval between markers D20S915 and D20S912. No mutation was detected in potential candidate genes, BFSP1 and CHMP4B. Conclusions Our results suggest that there is a new gene for infantile cataract on chromosome 20p12.2-p11.23. Our results suggest that new genes for infantile cataract could be found through further study of candidate genes at the 20q locus, which may provide insights into the pathogenic mechanisms of cataracts.

Published
2008

11. [Identification of a novel PHOX2A gene mutation in a Chinese family with congenital fibrosis of extraocular muscles type 2].

Author

Dong JM, Shen Q, Li J, Du W, Pang HL, Lin SF, and Bu J

Subjects
Base Sequence, Case-Control Studies, China, Female, Humans, Male, Molecular Sequence Data, Pedigree, Fibrosis genetics, Homeodomain Proteins genetics, Mutation, Ocular Motility Disorders genetics, Oculomotor Muscles abnormalities
Abstract

Objective: To investigate potential mutation of PHOX2A (or ARIX) gene in a Chinese family affected with congenital fibrosis of extraocular muscles tyep 2 (CFEOM2)., Methods: Genomic DNA was obtained from affected and unaffected members of the family. With an ABI PRSIM Linkage Mapping Set-MD10 kit, selected markers flanking the PHOX2A locus were used for linkage analysis. Exons of PHOX2 gene were amplified and sequenced. A total of 100 normal subjects were recruited as controls., Results: Genetic linkage was found at 11q13 between D11S4151 and D11S1320 and the PHOX2A gene. DNA sequencing has identified a heterozygous mutation in the exon 2 of the gene (227T to G, N76K). The same mutation was not found in the unaffected and 100 normal controls., Conclusion: A mutation of the PHOX2A gene 227T to G is responsible for the onset of congenital fibrosis of extraocular muscles type 2 in this Chinese family.

Published
2012
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12. [Linkage analysis of a Chinese family with autosomal dominant congenital retinaochoroidal coloboma].

Author

Dong JM, Bu J, Li J, Zhuo YL, and Wang LJ

Subjects
Asian People, Chromosome Mapping, DNA Mutational Analysis, Family, Female, Genetic Linkage, Genotype, Humans, Loss of Heterozygosity, Male, Pedigree, Polymerase Chain Reaction, Coloboma genetics, Lod Score, Microsatellite Repeats genetics, Myopia genetics
Abstract

Objective: To map the candidate gene by linkage analysis in a Chinese family with autosomal dominant congenital retinaochoroidal coloboma., Methods: A detailed clinical examination was performed for all patients in the family. The genomic DNA of all family members was extracted from peripheral blood leukocytes. Linkage analysis and genome-wide linkage screening was conducted using fluorescent detection of 398 microsatellite markers representing all autosomes at an average resolution of approximately 10 cM. Polymerase chain reaction was carried out to amplify all 398 microsatellite markers. The allele sizes were determined on ABI 3130-Avant genetic analyzer according to an internal size standard, and the results were analyzed using Genescan 3.1 and Genotyper 2.0 software., Results: Linkage analysis showed the markers D2S2382-D2S301-D2S2244-D2S163 co-segregated with the disease locus in all affected members. The maximum Lod score was 3.01(D2S2382)., Conclusion: The candidate region of the disease gene in the family was located in 2q34-2q35.

Published
2009
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