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163 results on '"Donetti E"'

3. PCSK9 modulates cardiac metabolism and impacts HFpEF

Author

Da Dalt, L., primary, Castiglioni, L., additional, Baragetti, A., additional, Audano, M., additional, Svecla, M., additional, Bonacina, F., additional, Pedretti, S., additional, Uboldi, P., additional, Benzoni, P., additional, Giannetti, F., additional, Barbuti, A., additional, Pellegatta, F., additional, Indino, S.L., additional, Donetti, E., additional, Sironi, L., additional, Mitro, N., additional, Catapano, A.L., additional, and Norata, G.D., additional

Published
2022
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10. Fenretinide treatment in APOE-KO mice severely alters erythrocyte turnover and causes a dramatic increase of circulating leukocytes resulting in a worsened atherosclerosis development

Author

Busnelli, M., primary, Manzini, S., additional, Bonacina, F., additional, Colombo, A., additional, Soldati, S., additional, Barbieri, S.S., additional, Amadio, P., additional, Sandrini, L., additional, Arnaboldi, F., additional, Donetti, E., additional, Laaksonen, R., additional, Paltrinieri, S., additional, Scanziani, E., additional, and Chiesa, G., additional

Published
2020
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17. Relevance of in vitro 3-D skin models in dissecting cytokine contribution to psoriasis pathogenesis

Author

Chiricozzi, Andrea, Romanelli, M., Panduri, S., Donetti, E., and Prignano, F.

Subjects
Models, Anatomic, RHE, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], IL-17, IFNγ, IL-17, IL-22, Psoriasis, RHE, Skin equivalent, TNFα, IL-22, TNFα, IL22, Animals, Cytokines, Humans, Psoriasis, Mast Cells, Settore MED/35 - MALATTIE CUTANEE E VENEREE, Skin equivalent, IFNγ, Skin
Abstract

Psoriasis is a chronic skin disease characterized by the activation of various T cell subsets secreting IFNγ, IL-17, and IL-22, dendritic cells producing TNFα and IFNα, and other immune cells including neutrophils and mast cells. Keratinocytes respond to different cytokine signals orchestrating innate and adaptive immune responses. In vitro studies sought to clarify the cytokine effects on keratinocytes in order to evaluate the centrality of these mediators in psoriasis pathogenesis. The aim of this review is to highlight the relevance of this peculiar in vitro approach in investigating cytokine effects on skin or multilayered epidermis. Particularly, we reported keynfinding

Published
2017

18. Consumo energetico ed inquinamento atmosferico, un binomio inscindibile

Author

BOLZACCHINI, EZIO, FERRERO, LUCA, PERRONE, MARIA GRAZIA, SANGIORGI, GIORGIA MAURA LUISA, Donetti, E, Pennacchio, A, Canepa, M, Bolzacchini, E, Donetti, E, Pennacchio, A, Ferrero, L, Perrone, M, and Sangiorgi, G

Subjects
CHIM/12 - CHIMICA DELL'AMBIENTE E DEI BENI CULTURALI, inquinamento atmosferico, isola di calore, pianificazione urbana
Published
2012

20. PRINCIPI DI ANATOMIA UMANA capitoli 1, 2, 3, 5

Author

Dolci, C., Donetti, E., Orsini, E., Quaranta, M., Zanetti, D., Campolo, F., Di Giacomo, D., Di Siena, S., Gori, M., and Pellegrini, M.

Subjects
Settore BIO/16 - Anatomia Umana
Published
2012

31. Consumo energetico ed inquinamento atmosferico, un binomio inscindibile

Author

Canepa, M, Bolzacchini, E, Donetti, E, Pennacchio, A, Ferrero, L, Perrone, M, Sangiorgi, G, BOLZACCHINI, EZIO, FERRERO, LUCA, PERRONE, MARIA GRAZIA, SANGIORGI, GIORGIA MAURA LUISA, Canepa, M, Bolzacchini, E, Donetti, E, Pennacchio, A, Ferrero, L, Perrone, M, Sangiorgi, G, BOLZACCHINI, EZIO, FERRERO, LUCA, PERRONE, MARIA GRAZIA, and SANGIORGI, GIORGIA MAURA LUISA

Published
2012

45. Early response in human breast skin cultures after a single dose of gamma-rays: an ultrastructural study.

Author

Donetti, E., Boschini, E., Bertelli, A. A. E., Sabatella, G., and Gagliano, N.

Subjects
*BREAST, *SKIN, *EPIDERMIS, *KERATINOCYTES, *IONIZING radiation, *IMMUNOHISTOCHEMISTRY
Abstract

Radiation therapy with ionising radiations (gamma-rays) is the main non-surgical treatment for cancer, but skin reaction is the most common side effect of such a treatment. At present, the scientific rationale of the management of skin response is still lacking. Though the radiation-induced dermal fibrosis was histologically characterized, little is known about the epithelial compartment overlaying fibronecrotic lesions, i.e. epidermis, and the early keratinocyte response are not yet fully understood. In this study we have investigated early effects of gamma-irradiation in organotypic breast skin cultures obtained after aesthetic surgery of healthy women (30–40 years old) (n=4). Skin biopsies in triplicate were placed epidermis upwards on Transwell plates and underwent a single dose of gamma-irradiation (200 cGray). Samples were harvested 24 hours after irradiation and routinely processed for either Araldite or Lowicryl embedding for immunohistochemistry of cytokeratin 10 (CK10), i.e., a major marker of suprabasal keratinocytes. In araldite ultrathin sections, no difference exists in epidermal architecture between non irradiated and irradiated fragments. In particular, basal cell degeneration was not apparent. However, in irradiated epidermis a marked condensation of keratin intermediate filaments was evident in the basal layer and in the lower spinous layer, where scattered pyknotic nuclei were also present. Desmosomes were abundant and present throughout all epidermal layers. CK10 immunogold confirmed the occurrence of a cytoskeletal rearrangement induced by a single dose of gamma-rays. Together with our previous observation by immunofluorescence analysis indicating that, in these experimental conditions, a strong inhibition of cell proliferation occurs, these results demonstrate that gamma-rays induce a very early alteration of epidermal homeostasis. A topical therapy before the irradiation can be thus a suitable approach to limit and/or avoid the onset of the early epidermal response, with particular regard to keratinocytes. [ABSTRACT FROM AUTHOR]

Published
2004
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48. Sperm protein 17 is expressed in the sperm fibrous sheath

Author

Albani Elena, Franceschini Barbara, Grizzi Fabio, Costa Francesco, Donetti Elena, Gagliano Nicoletta, Chiriva-Internati Maurizio, Levi-Setti Paolo E, Gioia Magda, Jenkins Marjorie, Cobos Everardo, and Kast W Martin

Subjects
Medicine
Abstract

Abstract Background Sperm protein 17 (Sp17) is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine and human somatic tissues. It was also recognized in two myeloma cell lines and in neoplastic cells from patients with multiple myeloma and ovarian carcinoma. These data all indicate that Sp17 is widely distributed in humans, expressed not only in germinal cells and in a variety of somatic tissues, but also in neoplastic cells of unrelated origin. Methods Sp17 expression was analyzed by immunocytochemistry and transmission electron microscopy on spermatozoa. Results Here, we demonstrate the ultrastructural localization of human Sp17 throughout the spermatozoa flagellar fibrous sheath, and its presence in spermatozoa during in vitro states from their ejaculation to the oocyte fertilization. Conclusion These findings suggest a possible role of Sp17 in regulating sperm maturation, capacitation, acrosomal reaction and interactions with the oocyte zona pellucida during the fertilization process. Further, the high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP)-binding motif within this region, suggest that Sp17 might play a regulatory role in a protein kinase A-independent AKAP complex in both germinal and somatic cells.

Published
2009
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