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4. Correction to: Frequency and clinical correlates of anti-nerve antibodies in a large population of CIDP patients included in the Italian database

Author

Liberatore, Giuseppe, De Lorenzo, Alberto, Giannotta, Claudia, Manganelli, Fiore, Filosto, Massimiliano, Cosentino, Giuseppe, Cocito, Dario, Briani, Chiara, Cortese, Andrea, Fazio, Raffaella, Lauria, Giuseppe, Clerici, Angelo Maurizio, Rosso, Tiziana, Marfia, Girolama Alessandra, Antonini, Giovanni, Cavaletti, Guido, Carpo, Marinella, Doneddu, Pietro Emiliano, Spina, Emanuele, Cotti Piccinelli, Stefano, Peci, Erdita, Querol, Luis, and Nobile‑Orazio, Eduardo

Published
2023
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8. Cytokines and chemokines in patients with chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy: A systematic review

Author

Cutellè, Claudia, primary, De Lorenzo, Alberto, additional, Doneddu, Pietro Emiliano, additional, Creta, Maria Francesca, additional, Selmi, Carlo, additional, Liberatore, Giuseppe, additional, Giordano, Andrea, additional, Gentile, Francesco, additional, Erre, Gian Luca, additional, and Nobile‐Orazio, Eduardo, additional

Published
2024
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9. Frequency and clinical correlates of anti-nerve antibodies in a large population of CIDP patients included in the Italian database

Author

Liberatore, Giuseppe, De Lorenzo, Alberto, Giannotta, Claudia, Manganelli, Fiore, Filosto, Massimiliano, Cosentino, Giuseppe, Cocito, Dario, Briani, Chiara, Cortese, Andrea, Fazio, Raffaella, Lauria, Giuseppe, Clerici, Angelo Maurizio, Rosso, Tiziana, Marfia, Girolama Alessandra, Antonini, Giovanni, Cavaletti, Guido, Carpo, Marinella, Doneddu, Pietro Emiliano, Spina, Emanuele, Cotti Piccinelli, Stefano, Peci, Erdita, Querol, Luis, and Nobile-Orazio, Eduardo

Published
2022
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10. Prolonged distal motor latency of median nerve does not improve diagnostic accuracy for CIDP

Author

Spina, Emanuele, Doneddu, Pietro Emiliano, Liberatore, Giuseppe, Cocito, Dario, Fazio, Raffaella, Briani, Chiara, Filosto, Massimiliano, Benedetti, Luana, Antonini, Giovanni, Cosentino, Giuseppe, Jann, Stefano, Mazzeo, Anna, Cortese, Andrea, Marfia, Girolama Alessandra, Clerici, Angelo Maurizio, Siciliano, Gabriele, Carpo, Marinella, Luigetti, Marco, Lauria, Giuseppe, Rosso, Tiziana, Cavaletti, Guido, Peci, Erdita, Tronci, Stefano, Ruiz, Marta, Piccinelli, Stefano Cotti, Schenone, Angelo, Leonardi, Luca, Gentile, Luca, Piccolo, Laura, Mataluni, Giorgia, Santoro, Lucio, Nobile-Orazio, Eduardo, and Manganelli, Fiore

Published
2022
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11. The neurophysiological lesson from the Italian CIDP database

Author

Spina, Emanuele, Doneddu, Pietro Emiliano, Liberatore, Giuseppe, Cocito, Dario, Fazio, Raffaella, Briani, Chiara, Filosto, Massimiliano, Benedetti, Luana, Antonini, Giovanni, Cosentino, Giuseppe, Jann, Stefano, Mazzeo, Anna, Cortese, Andrea, Marfia, Girolama Alessandra, Clerici, Angelo Maurizio, Siciliano, Gabriele, Carpo, Marinella, Luigetti, Marco, Lauria, Giuseppe, Rosso, Tiziana, Cavaletti, Guido, Peci, Erdita, Tronci, Stefano, Ruiz, Marta, Piccinelli, Stefano Cotti, Schenone, Angelo, Leonardi, Luca, Gentile, Luca, Piccolo, Laura, Mataluni, Giorgia, Santoro, Lucio, Nobile-Orazio, Eduardo, and Manganelli, Fiore

Published
2022
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12. Comparison of the diagnostic accuracy of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society and American Association of Electrodiagnostic Medicine diagnostic criteria for multifocal motor neuropathy.

Author

Doneddu, Pietro Emiliano, Gallo, Chiara, Gentile, Luca, Cocito, Dario, Falzone, Yuri, Di Stefano, Vincenzo, Inghilleri, Maurizio, Cosentino, Giuseppe, Matà, Sabrina, Mazzeo, Anna, Filosto, Massimiliano, Peci, Erdita, Sorrenti, Benedetta, Brighina, Filippo, Moret, Federica, Vegezzi, Elisa, Sperti, Martina, Risi, Barbara, and Nobile‐Orazio, Eduardo

Subjects
*NERVE conduction studies, *AMYOTROPHIC lateral sclerosis, *MOTOR neuron diseases, *PERIPHERAL nervous system, *EUROPEAN integration
Abstract

Background and Purpose Methods Results Conclusions This study was undertaken to compare the sensitivity and specificity of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) diagnostic criteria for multifocal motor neuropathy (MMN) with those of the American Association of Electrodiagnostic Medicine (AAEM).Sensitivity and specificity of the two sets of criteria were retrospectively evaluated in 53 patients with MMN and 280 controls with axonal peripheral neuropathy, inflammatory demyelinating polyneuropathy, or amyotrophic lateral sclerosis. Comparison of the utility of nerve conduction studies with different numbers of nerves examined was also assessed.The 2010 EFNS/PNS criteria had a sensitivity of 47% for definite MMN and 57% for probable/definite MMN, whereas the AAEM criteria had a sensitivity of 28% for definite MMN and 53% for probable/definite MMN. The sensitivity of the AAEM criteria was higher when utilizing area compared to amplitude reduction to define conduction block. Using supportive criteria, the sensitivity of the 2010 EFNS/PNS criteria for probable/definite MMN increased to 64%, and an additional 36% patients fulfilled the criteria (possible MMN). Specificity values for definite and probable/definite MMN were slightly higher with the AAEM criteria (100%) compared to the EFNS/PNS criteria (98.5% and 97%). Extended nerve conduction studies yielded slightly increased diagnostic sensitivity for both sets of criteria without significantly affecting specificity.In our patient populations, the 2010 EFNS/PNS criteria demonstrated higher sensitivity but slightly lower specificity compared to the AAEM criteria. Extended nerve conduction studies are advised to achieve slightly higher sensitivity while maintaining very high specificity. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Assessment of diagnostic criteria for multifocal motor neuropathy in patients included in the Italian database.

Author

Doneddu, Pietro Emiliano, Gentile, Luca, Cocito, Dario, Fazio, Raffaella, Luigetti, Marco, Briani, Chiara, Filosto, Massimiliano, Siciliano, Gabriele, Benedetti, Luana, Antonini, Giovanni, Matà, Sabrina, Marfia, Girolama Alessandra, Inghilleri, Maurizio, Manganelli, Fiore, Cosentino, Giuseppe, Brighina, Filippo, Carpo, Marinella, Carta, Francesca, Mazzeo, Anna, and Peci, Erdita

Subjects
*MOTOR neuron diseases, *DATABASES, *CEREBROSPINAL fluid examination, *NERVE conduction studies, *IMMUNOGLOBULIN M, *CARPAL tunnel syndrome
Abstract

Background and purpose: This study aimed to assess the diagnostic criteria, ancillary investigations and treatment response using real‐life data in multifocal motor neuropathy (MMN) patients. Methods: Clinical and laboratory data were collected from 110 patients enrolled in the Italian MMN database through a structured questionnaire. Twenty‐six patients were excluded due to the unavailability of nerve conduction studies or the presence of clinical signs and symptoms and electrodiagnostic abnormalities inconsistent with the MMN diagnosis. Analyses were conducted on 73 patients with a confirmed MMN diagnosis and 11 patients who did not meet the diagnostic criteria. Results: The European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) diagnostic criteria were variably applied. AUTHOR:When applying the American Association of Electrodiagnostic Medicine criteria, an additional 17% of patients fulfilled the criteria for probable/definite diagnosis whilst a further 9.5% missed the diagnosis. In 17% of the patients only compound muscle action potential amplitude, but not area, was measured and subsequently recorded in the database by the treating physician. Additional investigations, including anti‐GM1 immunoglobulin M antibodies, cerebrospinal fluid analysis, nerve ultrasound and magnetic resonance imaging, supported the diagnosis in 46%–83% of the patients. Anti‐GM1 immunoglobulin M antibodies and nerve ultrasound demonstrated the highest sensitivity. Additional tests were frequently performed outside the EFNS/PNS guideline recommendations. Conclusions: This study provides insights into the real‐world diagnostic and management strategies for MMN, highlighting the challenges in applying diagnostic criteria. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Impact of 2021 European Academy of Neurology/Peripheral Nerve Society diagnostic criteria on diagnosis and therapy of chronic inflammatory demyelinating polyradiculoneuropathy variants.

Author

De Lorenzo, Alberto, Liberatore, Giuseppe, Doneddu, Pietro Emiliano, Manganelli, Fiore, Cocito, Dario, Briani, Chiara, Fazio, Raffaella, Mazzeo, Anna, Schenone, Angelo, Di Stefano, Vincenzo, Cosentino, Giuseppe, Marfia, Girolama Alessandra, Benedetti, Luana, Carpo, Marinella, Filosto, Massimiliano, Antonini, Giovanni, Clerici, Angelo Maurizio, Luigetti, Marco, Matà, Sabrina, and Rosso, Tiziana

Subjects
CHRONIC inflammatory demyelinating polyradiculoneuropathy, PERIPHERAL nervous system, POLYNEUROPATHIES, ACTION potentials
Abstract

Background and purpose: There are different criteria for the diagnosis of different variants of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The 2021 European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) guidelines provide specific clinical criteria for each CIDP variant even if their therapeutical impact has not been investigated. Methods: We applied the clinical criteria for CIDP variants of the 2021 EAN/PNS guidelines to 369 patients included in the Italian CIDP database who fulfilled the 2021 EAN/PNS electrodiagnostic criteria for CIDP. Results: According to the 2021 EAN/PNS clinical criteria, 245 patients achieved a clinical diagnosis of typical CIDP or CIDP variant (66%). We identified 106 patients with typical CIDP (29%), 62 distal CIDP (17%), 28 multifocal or focal CIDP (7%), four sensory CIDP (1%), 27 sensory‐predominant CIDP (7%), 10 motor CIDP (3%), and eight motor‐predominant CIDP (2%). Patients with multifocal, distal, and sensory CIDP had milder impairment and symptoms. Patients with multifocal CIDP had less frequently reduced conduction velocity and prolonged F‐wave latency and had lower levels of cerebrospinal fluid protein. Patients with distal CIDP more frequently had reduced distal compound muscle action potentials. Patients with motor CIDP did not improve after steroid therapy, whereas those with motor‐predominant CIDP did. None of the patients with sensory CIDP responded to steroids, whereas most of those with sensory‐predominant CIDP did. Conclusions: The 2021 EAN/PNS criteria for CIDP allow a better characterization of CIDP variants, permitting their distinction from typical CIDP and more appropriate treatment for patients. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Unclassified clinical presentations of chronic inflammatory demyelinating polyradiculoneuropathy

Author

Doneddu, Pietro Emiliano, primary, Akyil, Houseyin, additional, Manganelli, Fiore, additional, Briani, Chiara, additional, Cocito, Dario, additional, Benedetti, Luana, additional, Mazzeo, Anna, additional, Fazio, Raffaella, additional, Filosto, Massimiliano, additional, Cosentino, Giuseppe, additional, Di Stefano, Vincenzo, additional, Antonini, Giovanni, additional, Marfia, Girolama Alessandra, additional, Inghilleri, Maurizio, additional, Siciliano, Gabriele, additional, Clerici, Angelo Maurizio, additional, Carpo, Marinella, additional, Schenone, Angelo, additional, Luigetti, Marco, additional, Lauria, Giuseppe, additional, Matà, Sabrina, additional, Rosso, Tiziana, additional, Minicuci, Giacomo Maria, additional, Lucchetta, Marta, additional, Cavaletti, Guido, additional, Liberatore, Giuseppe, additional, Spina, Emanuele, additional, Campagnolo, Marta, additional, Peci, Erdita, additional, Germano, Francesco, additional, Gentile, Luca, additional, Strano, Camilla, additional, Cotti Piccinelli, Stefano, additional, Vegezzi, Elisa, additional, Leonardi, Luca, additional, Mataluni, Giorgia, additional, Ceccanti, Marco, additional, Schirinzi, Erika, additional, Romozzi, Marina, additional, and Nobile-Orazio, Eduardo, additional

Published
2023
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21. Prospective open-label trial with rituximab in patients with chronic inflammatory demyelinating polyradiculoneuropathy not responding to conventional immune therapies

Author

Doneddu, Pietro Emiliano, Cocito, Dario, Fazio, Raffaella, Benedetti, Luana, Peci, Erdita, Liberatore, Giuseppe, Falzone, Yuri Matteo, Germano, Francesco, Gallia, Francesca, Giannotta, Claudia, Lleixà, Cinta, Bianchi, Elisa, and Nobile-Orazio, Eduardo

Abstract

BackgroundTo evaluate the efficacy of rituximab in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) patients not responding to conventional immune therapies.MethodsAn open-label, prospective exploratory study was conducted with intravenous rituximab on 17 CIDP patients who had not responded to at least two first-line therapies. The primary endpoint was to determine the proportion of patients who showed improvement 6 months after rituximab therapy. The percentage of responders to rituximab, along with a 95% CI, was reported and compared with the 30% response rate after other immunosuppressive drugs previously documented in the literature.Results13 of the 17 treated patients (76.5%) showed improvement at 6 months (95% CI 50.1 to 93.2). Among the 14 patients who completed the 12-month follow-up (2 were lost to follow-up after showing improvement at months 8 and 10, and 1 deteriorated at 6 months), 13 (92.9%) demonstrated improvement at 12 months (95% CI 66.1 to 99.8). Nerve conduction parameters improved by at least 20% in two nerves in 6 out of 15 (40%) patients at 6 months and in 7 out of 13 (53.9%) at 12 months. None of the treated patients withdrew from the study due to side effects. There was a significant reduction of circulating CD19+ cells 15 days, 2, 6 and 12 months after treatment.ConclusionRituximab seems to be a safe therapy in most patients with CIDP not responding to conventional immune therapies. The high percentage of patients who improved in this study suggests a possible positive effect of rituximab which is worth investigating in future randomised controlled clinical trials.Trial registration numberNCT05877040.

Published
2024
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24. Risk of disease relapse, safety and tolerability of SARS‐CoV‐2 vaccination in patients with chronic inflammatory neuropathies.

Author

Doneddu, Pietro Emiliano, Briani, Chiara, Cocito, Dario, Manganelli, Fiore, Fabrizi, Gian Maria, Matà, Sabrina, Mazzeo, Anna, Fazio, Raffaella, Benedetti, Luana, Luigetti, Marco, Inghilleri, Maurizio, Ruiu, Elisa, Siciliano, Gabriele, Cosentino, Giuseppe, Marfia, Girolama Alessandra, Carpo, Marinella, Filosto, Massimiliano, Antonini, Giovanni, Notturno, Francesca, and Sotgiu, Stefano

Subjects
*SARS-CoV-2, *CHRONIC inflammatory demyelinating polyradiculoneuropathy, *POLYNEUROPATHIES, *DISEASE relapse
Abstract

Background and purpose: The aim was to evaluate the risk of relapse after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination, and its safety and tolerability, in patients with chronic inflammatory neuropathies. Methods: In this multicenter, cohort and case‐crossover study, the risk of relapse associated with SARS‐CoV‐2 vaccination was assessed by comparing the frequency of relapse in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) patients who underwent or did not undergo vaccination. Frequency of relapse in the 3 months prior to and after vaccination, and safety and tolerability of SARS‐CoV‐2 vaccination, were also assessed. Results: In all, 336 patients were included (278 CIDP, 58 MMN). Three hundred and seven (91%) patients underwent SARS‐CoV‐2 vaccination. Twenty‐nine patients (9%) did not undergo vaccination. Mild and transient relapses were observed in 16 (5%) patients (13 CIDP, 3 MMN) after SARS‐CoV‐2 vaccination and in none of the patients who did not undergo vaccination (relative risk [RR] 3.21, 95% confidence interval [CI] 0.19–52.25). There was no increase in the specific risk of relapse associated with type of vaccine or diagnosis. Comparison with the 3‐month control period preceding vaccination revealed an increased risk of relapse after vaccination (RR 4.00, 95% CI 1.35–11.82), which was restricted to CIDP patients (RR 3.25, 95% CI 1.07–9.84). The safety profile of SARS‐CoV‐2 vaccination was characterized by short‐term, mild‐to‐moderate local and systemic adverse events. Conclusions: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination in CIDP and MMN patients does not seem to be associated with an increased risk of relapse at the primary end‐point, although a slightly increased risk in CIDP patients was found compared to the 3 months before vaccination. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Comparison of the diagnostic accuracy of the 2021 EAN/PNS and 2010 EFNS/PNS diagnostic criteria for chronic inflammatory demyelinating polyradiculoneuropathy

Author

Doneddu, Pietro Emiliano, primary, De Lorenzo, Alberto, additional, Manganelli, Fiore, additional, Cocito, Dario, additional, Fazio, Raffaella, additional, Briani, Chiara, additional, Mazzeo, Anna, additional, Filosto, Massimiliano, additional, Cosentino, Giuseppe, additional, Benedetti, Luana, additional, Schenone, Angelo, additional, Marfia, Girolama Alessandra, additional, Antonini, Giovanni, additional, Matà, Sabrina, additional, Luigetti, Marco, additional, Liberatore, Giuseppe, additional, Spina, Emanuele, additional, Peci, Erdita, additional, Strano, Camilla, additional, Cacciavillani, Mario, additional, Gentile, Luca, additional, Cotti Piccinelli, Stefano, additional, Cortese, Andrea, additional, Bianchi, Elisa, additional, and Nobile-Orazio, Eduardo, additional

Published
2022
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27. Guillain‐Barré syndrome and COVID ‐19: A 1‐year observational multicenter study

Author

Filosto, Massimiliano, primary, Cotti Piccinelli, Stefano, additional, Gazzina, Stefano, additional, Foresti, Camillo, additional, Frigeni, Barbara, additional, Servalli, Maria Cristina, additional, Sessa, Maria, additional, Cosentino, Giuseppe, additional, Marchioni, Enrico, additional, Ravaglia, Sabrina, additional, Briani, Chiara, additional, Castellani, Francesca, additional, Zara, Gabriella, additional, Bianchi, Francesca, additional, Del Carro, Ubaldo, additional, Fazio, Raffaella, additional, Filippi, Massimo, additional, Magni, Eugenio, additional, Natalini, Giuseppe, additional, Palmerini, Francesco, additional, Perotti, Anna Maria, additional, Bellomo, Andrea, additional, Osio, Maurizio, additional, Nascimbene, Caterina, additional, Carpo, Marinella, additional, Rasera, Andrea, additional, Squintani, Giovanna, additional, Doneddu, Pietro Emiliano, additional, Bertasi, Valeria, additional, Cotelli, Maria Sofia, additional, Bertolasi, Laura, additional, Fabrizi, Gian Maria, additional, Ferrari, Sergio, additional, Ranieri, Federico, additional, Caprioli, Francesca, additional, Grappa, Elena, additional, Manganotti, Paolo, additional, Bellavita, Giulia, additional, Furlanis, Giovanni, additional, De Maria, Giovanni, additional, Leggio, Ugo, additional, Poli, Loris, additional, Rasulo, Frank, additional, Latronico, Nicola, additional, Nobile‐Orazio, Eduardo, additional, Beghi, Ettore, additional, Padovani, Alessandro, additional, and Uncini, Antonino, additional

Published
2022
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31. Chronic inflammatory demyelinating polyradiculoneuropathy: Can we make a diagnosis in patients not fulfilling electrodiagnostic criteria?

Author

Liberatore, Giuseppe, Manganelli, Fiore, Doneddu, Pietro Emiliano, Cocito, Dario, Fazio, Raffaella, Briani, Chiara, Filosto, Massimiliano, Benedetti, Luana, Mazzeo, Anna, Antonini, Giovanni, Cosentino, Giuseppe, Jann, Stefano, Cortese, Andrea, Marfia, Girolama Alessandra, Clerici, Angelo Maurizio, Siciliano, Gabriele, Carpo, Marinella, Luigetti, Marco, Lauria, Giuseppe, Rosso, Tiziana, Cavaletti, Guido, Santoro, Lucio, Peci, Erdita, Tronci, Stefano, Ruiz, Marta, Piccinelli, Stefano Cotti, Schenone, Angelo, Leonardi, Luca, Toscano, Antonio, Mataluni, Giorgia, Spina, Emanuele, Gentile, Luca, Nobile‐orazio, Eduardo, Gallia, Francesca, Beronio, Alessandro, Piccolo, Laura, Fierro, Brigida, Pinuccia, Verrengia Elena, Bianchi, Elisa, Beghi, Ettore, Scrascia, Federica, Garnero, Martina, Sabatelli, Mario, Dacci, Patrizia, Schirinzi, Erika, and Balducci, Claudia

Published
2021

33. Guillain-Barré syndrome and COVID-19: an observational multicentre study from two Italian hotspot regions

Author

Filosto, Massimiliano, primary, Cotti Piccinelli, Stefano, additional, Gazzina, Stefano, additional, Foresti, Camillo, additional, Frigeni, Barbara, additional, Servalli, Maria Cristina, additional, Sessa, Maria, additional, Cosentino, Giuseppe, additional, Marchioni, Enrico, additional, Ravaglia, Sabrina, additional, Briani, Chiara, additional, Castellani, Francesca, additional, Zara, Gabriella, additional, Bianchi, Francesca, additional, Del Carro, Ubaldo, additional, Fazio, Raffaella, additional, Filippi, Massimo, additional, Magni, Eugenio, additional, Natalini, Giuseppe, additional, Palmerini, Francesco, additional, Perotti, Anna Maria, additional, Bellomo, Andrea, additional, Osio, Maurizio, additional, Scopelliti, Giuseppe, additional, Carpo, Marinella, additional, Rasera, Andrea, additional, Squintani, Giovanna, additional, Doneddu, Pietro Emiliano, additional, Bertasi, Valeria, additional, Cotelli, Maria Sofia, additional, Bertolasi, Laura, additional, Fabrizi, Gian Maria, additional, Ferrari, Sergio, additional, Ranieri, Federico, additional, Caprioli, Francesca, additional, Grappa, Elena, additional, Broglio, Laura, additional, De Maria, Giovanni, additional, Leggio, Ugo, additional, Poli, Loris, additional, Rasulo, Frank, additional, Latronico, Nicola, additional, Nobile-Orazio, Eduardo, additional, Padovani, Alessandro, additional, and Uncini, Antonino, additional

Published
2020
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35. Frequency of diabetes and other comorbidities in chronic inflammatory demyelinating polyradiculoneuropathy and their impact on clinical presentation and response to therapy

Author

Doneddu, Pietro Emiliano, primary, Cocito, Dario, additional, Manganelli, Fiore, additional, Fazio, Raffaella, additional, Briani, Chiara, additional, Filosto, Massimiliano, additional, Benedetti, Luana, additional, Bianchi, Elisa, additional, Jann, Stefano, additional, Mazzeo, Anna, additional, Antonini, Giovanni, additional, Cosentino, Giuseppe, additional, Marfia, Girolama Alessandra, additional, Cortese, Andrea, additional, Clerici, Angelo Maurizio, additional, Carpo, Marinella, additional, Schenone, Angelo, additional, Siciliano, Gabriele, additional, Luigetti, Marco, additional, Lauria, Giuseppe, additional, Rosso, Tiziana, additional, Cavaletti, Guido, additional, Beghi, Ettore, additional, Liberatore, Giuseppe, additional, Santoro, Lucio, additional, Spina, Emanuele, additional, Peci, Erdita, additional, Tronci, Stefano, additional, Ruiz, Marta, additional, Cotti Piccinelli, Stefano, additional, Verrengia, Elena Pinuccia, additional, Gentile, Luca, additional, Leonardi, Luca, additional, Mataluni, Giorgia, additional, Piccolo, Laura, additional, and Nobile-Orazio, Eduardo, additional

Published
2020
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36. Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy

Author

Liberatore, Giuseppe, primary, Giannotta, Claudia, additional, Sajeev, Blesson Punnen, additional, Morenghi, Emanuela, additional, Terenghi, Fabrizia, additional, Gallia, Francesca, additional, Doneddu, Pietro Emiliano, additional, Manganelli, Fiore, additional, Cocito, Dario, additional, Filosto, Massimiliano, additional, Antonini, Giovanni, additional, Cosentino, Giuseppe, additional, Marfia, Girolama Alessandra, additional, Clerici, Angelo Maurizio, additional, Lauria, Giuseppe, additional, Rosso, Tiziana, additional, Cavaletti, Guido, additional, and Nobile-Orazio, Eduardo, additional

Published
2020
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38. Atypical CIDP: diagnostic criteria, progression and treatment response. Data from the Italian CIDP Database

Author

Doneddu, Pietro Emiliano, primary, Cocito, Dario, additional, Manganelli, Fiore, additional, Fazio, Raffaella, additional, Briani, Chiara, additional, Filosto, Massimiliano, additional, Benedetti, Luana, additional, Mazzeo, Anna, additional, Marfia, Girolama Alessandra, additional, Cortese, Andrea, additional, Fierro, Brigida, additional, Jann, Stefano, additional, Beghi, Ettore, additional, Clerici, Angelo Maurizio, additional, Carpo, Marinella, additional, Schenone, Angelo, additional, Luigetti, Marco, additional, Lauria, Giuseppe, additional, Antonini, Giovanni, additional, Rosso, Tiziana, additional, Siciliano, Gabriele, additional, Cavaletti, Guido, additional, Liberatore, Giuseppe, additional, Santoro, Lucio, additional, Peci, Erdita, additional, Tronci, Stefano, additional, Ruiz, Marta, additional, Cotti Piccinelli, Stefano, additional, Toscano, Antonio, additional, Mataluni, Giorgia, additional, Piccolo, Laura, additional, Cosentino, Giuseppe, additional, Sabatelli, Mario, additional, and Nobile-Orazio, Eduardo, additional

Published
2018
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39. Impact of environmental factors and physical activity on disability and quality of life in CIDP.

Author

Doneddu, Pietro Emiliano, Bianchi, Elisa, Cocito, Dario, Manganelli, Fiore, Fazio, Raffaella, Filosto, Massimiliano, Beghi, Ettore, Mazzeo, Anna, Cosentino, Giuseppe, Cortese, Andrea, Jann, Stefano, Clerici, Angelo Maurizio, Antonini, Giovanni, Siciliano, Gabriele, Marfia, Girolama Alessandra, Briani, Chiara, Lauria, Giuseppe, Rosso, Tiziana, Cavaletti, Guido, and Carpo, Marinella

Subjects
*PHYSICAL activity, *DISABILITIES, *QUALITY of life, *FOOD habits, *SYMPTOMS, *CHILDREN with disabilities, *ORAL habits
Abstract

A few observational studies and randomized trials suggest that exercise and rehabilitation may improve activity limitation and quality of life (QoL) in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but the impact of other modifiable factors on the severity of the disease is not well understood. Using a structured questionnaire, we collected data on lifestyle and dietary habits of the patients included in the Italian CIDP database to investigate the possible influence of modifiable lifestyle factors on disability and QoL. Questionnaire data were available for 323 patients. The effect of lifestyle and dietary exposures on impairment, disability and QoL was evaluated using logistic regression models, adjusting for age, sex, disease duration, physical activity and smoking. Physical activity was associated with lower sensory impairment by the ISS scale, less disability by the INCAT and RODS scale and a better QoL in all the domains of EURO-QoL scale with the exception of anxiety/depression. None of the other parameters had an impact on these scales. This study adds evidence to the possible role of physical activity in improving symptom severity, disability and QoL in patients with CIDP. None of the other environmental factors investigated appeared to have an impact on the severity and health perception of CIDP. [ABSTRACT FROM AUTHOR]

Published
2020
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40. Guillain-Barré syndrome and COVID-19: an observational multicentre study from two Italian hotspot regions

Author

Filosto, Massimiliano, Cotti Piccinelli, Stefano, Gazzina, Stefano, Foresti, Camillo, Frigeni, Barbara, Servalli, Maria Cristina, Sessa, Maria, Cosentino, Giuseppe, Marchioni, Enrico, Ravaglia, Sabrina, Briani, Chiara, Castellani, Francesca, Zara, Gabriella, Bianchi, Francesca, Del Carro, Ubaldo, Fazio, Raffaella, Filippi, Massimo, Magni, Eugenio, Natalini, Giuseppe, Palmerini, Francesco, Perotti, Anna Maria, Bellomo, Andrea, Osio, Maurizio, Scopelliti, Giuseppe, Carpo, Marinella, Rasera, Andrea, Squintani, Giovanna, Doneddu, Pietro Emiliano, Bertasi, Valeria, Cotelli, Maria Sofia, Bertolasi, Laura, Fabrizi, Gian Maria, Ferrari, Sergio, Ranieri, Federico, Caprioli, Francesca, Grappa, Elena, Broglio, Laura, De Maria, Giovanni, Leggio, Ugo, Poli, Loris, Rasulo, Frank, Latronico, Nicola, Nobile-Orazio, Eduardo, Padovani, Alessandro, and Uncini, Antonino

Abstract

ObjectiveSingle cases and small series of Guillain-Barré syndrome (GBS) have been reported during the SARS-CoV-2 outbreak worldwide. We evaluated incidence and clinical features of GBS in a cohort of patients from two regions of northern Italy with the highest number of patients with COVID-19.MethodsGBS cases diagnosed in 12 referral hospitals from Lombardy and Veneto in March and April 2020 were retrospectively collected. As a control population, GBS diagnosed in March and April 2019 in the same hospitals were considered.ResultsIncidence of GBS in March and April 2020 was 0.202/100 000/month (estimated rate 2.43/100 000/year) vs 0.077/100 000/month (estimated rate 0.93/100 000/year) in the same months of 2019 with a 2.6-fold increase. Estimated incidence of GBS in COVID-19-positive patients was 47.9/100 000 and in the COVID-19-positive hospitalised patients was 236/100 000. COVID-19-positive patients with GBS, when compared with COVID-19-negative subjects, showed lower MRC sum score (26.3±18.3 vs 41.4±14.8, p=0.006), higher frequency of demyelinating subtype (76.6% vs 35.3%, p=0.011), more frequent low blood pressure (50% vs 11.8%, p=0.017) and higher rate of admission to intensive care unit (66.6% vs 17.6%, p=0.002).ConclusionsThis study shows an increased incidence of GBS during the COVID-19 outbreak in northern Italy, supporting a pathogenic link. COVID-19-associated GBS is predominantly demyelinating and seems to be more severe than non-COVID-19 GBS, although it is likely that in some patients the systemic impairment due to COVID-19 might have contributed to the severity of the whole clinical picture.

Published
2021
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43. Atypical CIDP: diagnostic criteria, progression and treatment response. Data from the Italian CIDP Database.

Author

Doneddu, Pietro Emiliano, Cocito, Dario, Manganelli, Fiore, Fazio, Raffaella, Briani, Chiara, Filosto, Massimiliano, Benedetti, Luana, Mazzeo, Anna, Marfia, Girolama Alessandra, Cortese, Andrea, Fierro, Brigida, Jann, Stefano, Beghi, Ettore, Clerici, Angelo Maurizio, Carpo, Marinella, Schenone, Angelo, Luigetti, Marco, Lauria, Giuseppe, Antonini, Giovanni, and Rosso, Tiziana

Subjects
DISEASE duration, FATHERS, SYMPTOMS
Abstract

Objectives: A few variants of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) have been described, but their frequency and evolution to typical CIDP remain unclear. To determine the frequency and characteristics of the CIDP variants, their possible evolution to typical CIDP, and treatment response.Methods: We applied a set of diagnostic criteria to 460 patients included in a database of Italian patients with CIDP. Clinical characteristics and treatment response were reviewed for each patient. The Kaplan-Meier curve was used to estimate the progression rate from atypical to typical CIDP.Results: At the time of inclusion, 376 (82%) patients had a diagnosis of typical CIDP while 84 (18%) had atypical CIDP, including 34 (7%) with distal acquired demyelinating symmetric neuropathy (DADS), 17 (4%) with purely motor, 17 (4%) with Lewis-Sumner syndrome (LSS) and 16 (3.5%) with purely sensory CIDP. Based on retrospective review of the symptoms and signs present at onset and for at least 1 year, 180 (39%) patients had an initial diagnosis compatible with atypical CIDP that in 96 (53%) patients evolved to typical CIDP. Mean disease duration was longer in patients evolving to typical CIDP than in those not evolving (p=0.0016). Patients with DADS and LSS had a less frequent response to immunoglobulin than those with typical CIDP, while patients with purely motor and sensory CIDP had a similar treatment response.Conclusions: The proportion of patients with atypical CIDP varies during the disease course. DADS and LSS have a less frequent response to intravenous immunoglobulin compared with typical CIDP, raising the possibility of a different underlying pathogenetic mechanism. [ABSTRACT FROM AUTHOR]

Published
2019
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45. Exploratory screening for Fabry’s disease in young adults with cerebrovascular disorders in northern Sardinia

Author

Fancellu, Laura, primary, Borsini, Walter, additional, Romani, Ilaria, additional, Pirisi, Angelo, additional, Deiana, Giovanni Andrea, additional, Sechi, Elia, additional, Doneddu, Pietro Emiliano, additional, Rassu, Anna Laura, additional, Demurtas, Rita, additional, Scarabotto, Anna, additional, Cassini, Pamela, additional, Arbustini, Eloisa, additional, and Sechi, GianPietro, additional

Published
2015
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46. Comparison of the diagnostic accuracy of the 2021 EAN/PNS and 2010 EFNS/PNS diagnostic criteria for chronic inflammatory demyelinating polyradiculoneuropathy

Author

Pietro Emiliano Doneddu, Alberto De Lorenzo, Fiore Manganelli, Dario Cocito, Raffaella Fazio, Chiara Briani, Anna Mazzeo, Massimiliano Filosto, Giuseppe Cosentino, Luana Benedetti, Angelo Schenone, Girolama Alessandra Marfia, Giovanni Antonini, Sabrina Matà, Marco Luigetti, Giuseppe Liberatore, Emanuele Spina, Erdita Peci, Camilla Strano, Mario Cacciavillani, Luca Gentile, Stefano Cotti Piccinelli, Andrea Cortese, Elisa Bianchi, Eduardo Nobile-Orazio, Doneddu, Pietro Emiliano, De Lorenzo, Alberto, Manganelli, Fiore, Cocito, Dario, Fazio, Raffaella, Briani, Chiara, Mazzeo, Anna, Filosto, Massimiliano, Cosentino, Giuseppe, Benedetti, Luana, Schenone, Angelo, Marfia, Girolama Alessandra, Antonini, Giovanni, Matà, Sabrina, Luigetti, Marco, Liberatore, Giuseppe, Spina, Emanuele, Peci, Erdita, Strano, Camilla, Cacciavillani, Mario, Gentile, Luca, Cotti Piccinelli, Stefano, Cortese, Andrea, Bianchi, Elisa, and Nobile-Orazio, Eduardo

Subjects
Neural Conduction, neuroimmunology, Settore MED/26, Sensitivity and Specificity, Psychiatry and Mental health, EMG, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Neurology, Humans, Surgery, neuropathy, Neurology (clinical), Peripheral Nerves, neuromuscular, neurophysiology, Retrospective Studies
Abstract

ObjectivesTo compare the sensitivity and specificity of the 2021 European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) diagnostic criteria for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with those of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS).MethodsSensitivity and specificity of the two sets of criteria were evaluated in 330 patients with CIDP and 166 axonal peripheral neuropathy controls. Comparison of the utility of nerve conduction studies with different number of nerves examined and of the sensitivity and specificity of the two criteria in typical CIDP and its variants were assessed.ResultsEFNS/PNS criteria had a sensitivity of 92% for possible CIDP and 85% for probable/definite CIDP, while the EAN/PNS criteria had a sensitivity of 83% for possible CIDP and 74% for CIDP. Using supportive criteria, the sensitivity of the EAN/PNS criteria for possible CIDP increased to 85% and that of CIDP to 77%, remaining lower than that of the EFNS/PNS criteria. Specificity of the EFNS/PNS criteria was 68% for possible CIDP and 84% for probable/definite CIDP, while the EAN/PNS criteria had a specificity of 88% for possible CIDP and 98% for CIDP. More extended studies increased the sensitivity of both sets of criteria by 4%–7% but reduced their specificity by 2%–3%. The EFNS/PNS criteria were more sensitive for the diagnosis of typical CIDP while the EAN/PNS criteria were more specific for the diagnosis of distal and sensory CIDP.ConclusionsIn our population, the EAN/PNS criteria were more specific but less sensitive than the EFNS/PNS criteria. With the EAN/PNS criteria, more extended nerve conduction studies are recommended to obtain an acceptable sensitivity while maintaining a high specificity.

Published
2022

47. Atypical CIDP: diagnostic criteria, progression and treatment response. Data from the Italian CIDP Database

Author

Pietro Emiliano, Doneddu, Dario, Cocito, Fiore, Manganelli, Raffaella, Fazio, Chiara, Briani, Massimiliano, Filosto, Luana, Benedetti, Anna, Mazzeo, Girolama Alessandra, Marfia, Andrea, Cortese, Brigida, Fierro, Stefano, Jann, Ettore, Beghi, Angelo Maurizio, Clerici, Marinella, Carpo, Angelo, Schenone, Marco, Luigetti, Giuseppe, Lauria, Giovanni, Antonini, Tiziana, Rosso, Gabriele, Siciliano, Guido, Cavaletti, Giuseppe, Liberatore, Lucio, Santoro, Erdita, Peci, Stefano, Tronci, Marta, Ruiz, Stefano, Cotti Piccinelli, Antonio, Toscano, Giorgia, Mataluni, Laura, Piccolo, Giuseppe, Cosentino, Mario, Sabatelli, Eduardo, Nobile-Orazio, Claudia, Balducci, Doneddu, P, Cocito, D, Manganelli, F, Fazio, R, Briani, C, Filosto, M, Benedetti, L, Mazzeo, A, Marfia, G, Cortese, A, Fierro, B, Jann, S, Beghi, E, Clerici, A, Carpo, M, Schenone, A, Luigetti, M, Lauria, G, Antonini, G, Rosso, T, Siciliano, G, Cavaletti, G, Liberatore, G, Santoro, L, Peci, E, Tronci, S, Ruiz, M, Cotti Piccinelli, S, Toscano, A, Mataluni, G, Piccolo, L, Cosentino, G, Sabatelli, M, Nobile-Orazio, E, Doneddu, Pietro Emiliano, Cocito, Dario, Manganelli, Fiore, Fazio, Raffaella, Briani, Chiara, Filosto, Massimiliano, Benedetti, Luana, Mazzeo, Anna, Marfia, Girolama Alessandra, Cortese, Andrea, Fierro, Brigida, Jann, Stefano, Beghi, Ettore, Clerici, Angelo Maurizio, Carpo, Marinella, Schenone, Angelo, Luigetti, Marco, Lauria, Giuseppe, Antonini, Giovanni, Rosso, Tiziana, Siciliano, Gabriele, Cavaletti, Guido, Liberatore, Giuseppe, Santoro, Lucio, Peci, Erdita, Tronci, Stefano, Ruiz, Marta, Cotti Piccinelli, Stefano, Toscano, Antonio, Mataluni, Giorgia, Piccolo, Laura, Cosentino, Giuseppe, Sabatelli, Mario, and Nobile-Orazio, Eduardo

Subjects
Adult, Male, Treatment response, lewis-sumner syndrome, Adolescent, Databases, Factual, Disease duration, chronic inflammatory demyelinating polyradiculoneuropathy, CIDP, diagnostic criteria, distal acquired demyelinating symmetric neuropathy, Surgery, Neurology (clinical), Psychiatry and Mental Health, Kaplan-Meier Estimate, computer.software_genre, Disease course, Young Adult, lewis–sumner syndrome, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, In patient, Child, Aged, Retrospective Studies, Aged, 80 and over, Retrospective review, Database, business.industry, Polyradiculoneuropathy, Middle Aged, medicine.disease, Psychiatry and Mental health, surgery, neurology, psychiatry and mental health, Italy, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Disease Progression, Female, Settore MED/26 - Neurologia, Progression rate, business, computer, 030217 neurology & neurosurgery
Abstract

ObjectivesA few variants of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) have been described, but their frequency and evolution to typical CIDP remain unclear. To determine the frequency and characteristics of the CIDP variants, their possible evolution to typical CIDP, and treatment response.MethodsWe applied a set of diagnostic criteria to 460 patients included in a database of Italian patients with CIDP. Clinical characteristics and treatment response were reviewed for each patient. The Kaplan-Meier curve was used to estimate the progression rate from atypical to typical CIDP.ResultsAt the time of inclusion, 376 (82%) patients had a diagnosis of typical CIDP while 84 (18%) had atypical CIDP, including 34 (7%) with distal acquired demyelinating symmetric neuropathy (DADS), 17 (4%) with purely motor, 17 (4%) with Lewis-Sumner syndrome (LSS) and 16 (3.5%) with purely sensory CIDP. Based on retrospective review of the symptoms and signs present at onset and for at least 1 year, 180 (39%) patients had an initial diagnosis compatible with atypical CIDP that in 96 (53%) patients evolved to typical CIDP. Mean disease duration was longer in patients evolving to typical CIDP than in those not evolving (p=0.0016). Patients with DADS and LSS had a less frequent response to immunoglobulin than those with typical CIDP, while patients with purely motor and sensory CIDP had a similar treatment response.ConclusionsThe proportion of patients with atypical CIDP varies during the disease course. DADS and LSS have a less frequent response to intravenous immunoglobulin compared with typical CIDP, raising the possibility of a different underlying pathogenetic mechanism.

Published
2018

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