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2,781 results on '"Donato, F"'

5. Cosmic-ray Antinuclei as Messengers of New Physics: Status and Outlook for the New Decade

Author

von Doetinchem, P., Perez, K., Aramaki, T., Baker, S., Barwick, S., Bird, R., Boezio, M., Boggs, S. E., Cui, M., Datta, A., Donato, F., Evoli, C., Fabris, L., Fabbietti, L., Bueno, E. Ferronato, Fornengo, N., Fuke, H., Gerrity, C., Coral, D. Gomez, Hailey, C., Hooper, D., Kachelriess, M., Korsmeier, M., Kozai, M., Lea, R., Li, N., Lowell, A., Manghisoni, M., Moskalenko, I. V., Munini, R., Naskret, M., Nelson, T., Ng, K. C. Y., Nozzoli, F., Oliva, A., Ong, R. A., Osteria, G., Pierog, T., Poulin, V., Profumo, S., Poeschl, T., Quinn, S., Re, V., Rogers, F., Ryan, J., Saffold, N., Sakai, K., Salati, P., Schael, S., Serksnyte, L., Shukla, A., Stoessl, A., Tjemsland, J., Vannuccini, E., Vecchi, M., Winkler, M. W., Wright, D., Xiao, M., Xu, W., Yoshida, T., Zampa, G., and Zuccon, P.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The precise measurement of cosmic-ray antinuclei serves as an important means for identifying the nature of dark matter and other new astrophysical phenomena, and could be used with other cosmic-ray species to understand cosmic-ray production and propagation in the Galaxy. For instance, low-energy antideuterons would provide a "smoking gun" signature of dark matter annihilation or decay, essentially free of astrophysical background. Studies in recent years have emphasized that models for cosmic-ray antideuterons must be considered together with the abundant cosmic antiprotons and any potential observation of antihelium. Therefore, a second dedicated Antideuteron Workshop was organized at UCLA in March 2019, bringing together a community of theorists and experimentalists to review the status of current observations of cosmic-ray antinuclei, the theoretical work towards understanding these signatures, and the potential of upcoming measurements to illuminate ongoing controversies. This review aims to synthesize this recent work and present implications for the upcoming decade of antinuclei observations and searches. This includes discussion of a possible dark matter signature in the AMS-02 antiproton spectrum, the most recent limits from BESS Polar-II on the cosmic antideuteron flux, and reports of candidate antihelium events by AMS-02; recent collider and cosmic-ray measurements relevant for antinuclei production models; the state of cosmic-ray transport models in light of AMS-02 and Voyager data; and the prospects for upcoming experiments, such as GAPS. This provides a roadmap for progress on cosmic antinuclei signatures of dark matter in the coming years., Comment: 45 pages, 14 figures

Published
2020
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6. Colorectal Cancer Diagnosis through Breath Test Using a Portable Breath Analyzer—Preliminary Data

Author

Arcangelo Picciariello, Agnese Dezi, Leonardo Vincenti, Marcello Giuseppe Spampinato, Wenzhe Zang, Pamela Riahi, Jared Scott, Ruchi Sharma, Xudong Fan, and Donato F. Altomare

Subjects
colorectal cancer screening, volatile organic compounds, micro GC, breath biopsy, Chemical technology, TP1-1185
Abstract

Screening methods available for colorectal cancer (CRC) to date are burdened by poor reliability and low patient adherence and compliance. An altered pattern of volatile organic compounds (VOCs) in exhaled breath has been proposed as a non-invasive potential diagnostic tool for distinguishing CRC patients from healthy controls (HC). The aim of this study was to evaluate the reliability of an innovative portable device containing a micro-gas chromatograph in enabling rapid, on-site CRC diagnosis through analysis of patients’ exhaled breath. In this prospective trial, breath samples were collected in a tertiary referral center of colorectal surgery, and analysis of the chromatograms was performed by the Biomedical Engineering Department. The breath of patients with CRC and HC was collected into Tedlar bags through a Nafion filter and mouthpiece with a one-way valve. The breath samples were analyzed by an automated portable gas chromatography device. Relevant volatile biomarkers and discriminant chromatographic peaks were identified through machine learning, linear discriminant analysis and principal component analysis. A total of 68 subjects, 36 patients affected by histologically proven CRC with no evidence of metastases and 32 HC with negative colonoscopies, were enrolled. After testing a training set (18 CRC and 18 HC) and a testing set (18 CRC and 14 HC), an overall specificity of 87.5%, sensitivity of 94.4% and accuracy of 91.2% in identifying CRC patients was found based on three VOCs. Breath biopsy may represent a promising non-invasive method of discriminating CRC patients from HC.

Published
2024
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7. Spin Physics with a fixed-target experiment at the LHC

Author

Echevarria, M. G., Brodsky, S. J., Cavoto, G., Da Silva, C., Donato, F., Ferreiro, E. G., Hadjidakis, C., Hřivnáčová, I., Kikola, D., Klein, A., Kurepin, A., Kusina, A., Lansberg, J. P., Lorcé, C., Lyonnet, F., Makdisi, Y., Massacrier, L., Porteboeuf, S., Quintans, C., Rakotozafindrabe, A., Robbe, P., Scandale, W., Schienbein, I., Seixas, J., Shao, H. S., Signori, A., Topilskaya, N., Trzeciak, B., Uras, A., Wagner, J., Yamanaka, N., Yang, Z., and Zelenski, A.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

The multi-TeV proton and ion beams of the LHC would allow for the most energetic fixed-target experiment ever. In particular, $pp$, $p$d and $p$A collisions could be performed at $\sqrt{s_{NN}}$ = 115~GeV, as well as Pb$p$ and PbA collisions at $\sqrt{s_{NN}}$ = 72~GeV, in a parasitic way by making use of the already existing LHCb and ALICE detectors in fixed-target mode. This would offer the possibility to carry out a ground-breaking physics program, to study the nucleon and nuclear structure at high $x$, the spin content of the nucleon and the phases of the nuclear matter from a new rapidity viewpoint. In this talk I focus on the spin physics axis of the full program developed so far by the AFTER@LHC study group., Comment: 6 pages, 4 figures. Proceedings of the 23rd International Spin Physics Symposium (SPIN 2018), Ferrara, Italy, September 10-14, 2018

Published
2019

8. High luminosity fixed-target experiment at the LHC

Author

Hadjidakis, C., Brodsky, S. J., Cavoto, G., Da Silva, C., Donato, F., Echevarria, M. G., Ferreiro, E. G., Hřivnáčová, I., Kikola, D., Klein, A., Kurepin, A., Kusina, A., Lansberg, J. P., Lorcé, C., Lyonnet, F., Makdisi, Y., Massacrier, L., Porteboeuf, S., Quintans, C., Rakotozafindrabe, A., Robbe, P., Scandale, W., Schienbein, I., Seixas, J., Shao, H. S., Signori, A., Topilskaya, N., Trzeciak, B., Uras, A., Wagner, J., Yamanaka, N., Yang, Z., and Zelenski, A.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

By extracting the beam with a bent crystal or by using an internal gas target, the multi-TeV proton and lead LHC beams allow one to perform the most energetic fixed-target experiments ever and to study $pp$, $p$d and $p$A collisions at $\sqrt{s_{NN}}=115$ GeV and Pb$p$ and PbA collisions at $\sqrt{s_{NN}}=72$ GeV with high precision and modern detection techniques. Such studies would address open questions in the domain of the nucleon and nucleus partonic structure at high-$x$, quark-gluon plasma and, by using longitudinally or transversally polarised targets, spin physics. In this paper, we will review the technical solutions to obtain a high-luminosity fixed-target experiment at the LHC and will discuss their possible implementations with the ALICE and LHCb detectors., Comment: 5 pages, 2 figures, 9th International Conference on Hard and Electromagnetic Probes of High-Energy Nuclear Collisions : Hard Probes 2018. (HP2018)

Published
2019

9. Ultra-peripheral-collision studies in the fixed-target mode with the proton and lead LHC beams

Author

Yamanaka, N., Hadjidakis, C., Kikola, D., Lansberg, J. P., Massacrier, L., Echevarria, M. G., Kusina, A., Schienbein, I., Seixas, J., Shao, H. S., Signori, A., Trzeciak, B., Brodsky, S. J., Cavoto, G., Da Silva, C., Donato, F., Ferreiro, E. G., Hrivnacova, I., Klein, A., Kurepin, A., Lorce, C., Lyonnet, F., Makdisi, Y., Porteboeuf, S., Quintans, C., Rakotozafindrabe, A., Robbe, P., Scandale, W., Topilskaya, N., Uras, A., Wagner, J., Yang, Z., and Zelenski, A.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment, Nuclear Theory
Abstract

We address the physics case related to the studies of ultra-peripheral pH, pPb, PbH, and PbPb collisions in the fixed-target mode at the LHC. In particular, we discuss how one can measure the gluon generalized parton distribution E_g(x,xi,t) in exclusive J/psi photoproduction with a transversely polarized hydrogen target., Comment: 6 pages, 3 figures, Proceedings of the International Conference on Hard & Electromagnetic Probes of High-Energy Nuclear Collisions (Hard Probes 2018), 30 September-5 October 2018, Aix-Les-Bains, France

Published
2019

10. Probing the high-x content of the nuclei in the fixed-target mode at the LHC

Author

Kusina, A., Hadjidakis, C., Kikola, D., Lansberg, J. P., Massacrier, L., Echevarria, M. G., Schienbein, I., Seixas, J., Shao, H. S., Signori, A., Trzeciak, B., Brodsky, S. J., Cavoto, G., Da Silva, C., Donato, F., Ferreiro, E. G., Hrivnacova, I., Klein, A., Kurepin, A., Lorce, C., Lyonnet, F., Makdisi, Y., Porteboeuf, S., Quintans, C., Rakotozafindrabe, A., Robbe, P., Scandale, W., Topilskaya, N., Uras, A., Wagner, J., Yamanaka, N., Yang, Z., and Zelenski, A.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

Using the LHCb and ALICE detectors in the fixed-target mode at the LHC offers unprecedented possibilities to study the quark, gluon and heavy-quark content of the proton and nuclei in the poorly known region of the high-momentum fractions. We review our projections for studies of Drell-Yan, charm, beauty and quarkonium production with both detector set-ups used with various nuclear targets and the LHC proton beams. Based on this, we show the expected improvement in the determination of the quark, charm and gluon proton and nuclear PDFs as well as discuss the implication for a better understanding of the cold-nuclear-matter effects in hard-probe production in proton-nucleus collisions., Comment: Proceedings of the Hard Probes 2018 conference

Published
2019

11. Cosmic-ray antinuclei as messengers of new physics: status and outlook for the new decade.

Author

von Doetinchem, P, Perez, K, Aramaki, T, Baker, S, Barwick, S, Bird, R, Boezio, M, Boggs, SE, Cui, M, Datta, A, Donato, F, Evoli, C, Fabris, L, Fabbietti, L, Ferronato Bueno, E, Fornengo, N, Fuke, H, Gerrity, C, Gomez Coral, D, Hailey, C, Hooper, D, Kachelriess, M, Korsmeier, M, Kozai, M, Lea, R, Li, N, Lowell, A, Manghisoni, M, Moskalenko, IV, Munini, R, Naskret, M, Nelson, T, Ng, KCY, Nozzoli, F, Oliva, A, Ong, RA, Osteria, G, Pierog, T, Poulin, V, Profumo, S, Pöschl, T, Quinn, S, Re, V, Rogers, F, Ryan, J, Saffold, N, Sakai, K, Salati, P, Schael, S, Serksnyte, L, Shukla, A, Stoessl, A, Tjemsland, J, Vannuccini, E, Vecchi, M, Winkler, MW, Wright, D, Xiao, M, Xu, W, Yoshida, T, Zampa, G, and Zuccon, P

Subjects
baryon asymmetry, cosmic ray experiments, cosmic ray theory, dark matter experiments, astro-ph.HE, Nuclear & Particles Physics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics
Abstract

The precise measurement of cosmic-ray antinuclei serves as an important means for identifying the nature of dark matter and other new astrophysical phenomena, and could be used with other cosmic-ray species to understand cosmic-ray production and propagation in the Galaxy. For instance, low-energy antideuterons would provide a "smoking gun" signature of dark matter annihilation or decay, essentially free of astrophysical background. Studies in recent years have emphasized that models for cosmic-ray antideuterons must be considered together with the abundant cosmic antiprotons and any potential observation of antihelium. Therefore, a second dedicated Antideuteron Workshop was organized at UCLA in March 2019, bringing together a community of theorists and experimentalists to review the status of current observations of cosmic-ray antinuclei, the theoretical work towards understanding these signatures, and the potential of upcoming measurements to illuminate ongoing controversies. This review aims to synthesize this recent work and present implications for the upcoming decade of antinuclei observations and searches. This includes discussion of a possible dark matter signature in the AMS-02 antiproton spectrum, the most recent limits from BESS Polar-II on the cosmic antideuteron flux, and reports of candidate antihelium events by AMS-02; recent collider and cosmic-ray measurements relevant for antinuclei production models; the state of cosmic-ray transport models in light of AMS-02 and Voyager data; and the prospects for upcoming experiments, such as GAPS. This provides a roadmap for progress on cosmic antinuclei signatures of dark matter in the coming years.

Published
2020

12. The international anorectal physiology working group (IAPWG) recommendations: Standardized testing protocol and the London classification for disorders of anorectal function

Author

Carrington, Emma V, Heinrich, Henriette, Knowles, Charles H, Fox, Mark, Rao, Satish, Altomare, Donato F, Bharucha, Adil E, Burgell, Rebecca, Chey, William D, Chiarioni, Guiseppe, Dinning, Philip, Emmanuel, Anton, Farouk, Ridzuan, Felt‐Bersma, Richelle JF, Jung, Kee Wook, Lembo, Anthony, Malcolm, Allison, Mittal, Ravinder K, Mion, Franҫois, Myung, Seung‐Jae, O’Connell, P Ronan, Pehl, Christian, Remes‐Troche, Jose María, Reveille, R Matthew, Vaizey, Carolynne J, Vitton, Veronique, Whitehead, William E, Wong, Reuben K, Scott, S Mark, and Group, All members of the International Anorectal Physiology Working

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Digestive Diseases, Anal Canal, Gastroenterology, Humans, Intestinal Diseases, Manometry, anorectal function testing, anorectal manometry, balloon expulsion test, functional anorectal disorders, rectal sensory test, All members of the International Anorectal Physiology Working Group, Neurosciences, Medical Physiology, Gastroenterology & Hepatology, Clinical sciences, Medical physiology
Abstract

BackgroundThis manuscript summarizes consensus reached by the International Anorectal Physiology Working Group (IAPWG) for the performance, terminology used, and interpretation of anorectal function testing including anorectal manometry (focused on high-resolution manometry), the rectal sensory test, and the balloon expulsion test. Based on these measurements, a classification system for disorders of anorectal function is proposed.MethodsTwenty-nine working group members (clinicians/academics in the field of gastroenterology, coloproctology, and gastrointestinal physiology) were invited to six face-to-face and three remote meetings to derive consensus between 2014 and 2018.Key recommendationsThe IAPWG protocol for the performance of anorectal function testing recommends a standardized sequence of maneuvers to test rectoanal reflexes, anal tone and contractility, rectoanal coordination, and rectal sensation. Major findings not seen in healthy controls defined by the classification are as follows: rectoanal areflexia, anal hypotension and hypocontractility, rectal hyposensitivity, and hypersensitivity. Minor and inconclusive findings that can be present in health and require additional information prior to diagnosis include anal hypertension and dyssynergia.Conclusions and inferencesThis framework introduces the IAPWG protocol and the London classification for disorders of anorectal function based on objective physiological measurement. The use of a common language to describe results of diagnostic tests, standard operating procedures, and a consensus classification system is designed to bring much-needed standardization to these techniques.

Published
2020

13. Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort

Author

Greijdanus, Nynke G., Wienholts, Kiedo, Ubels, Sander, Talboom, Kevin, Hannink, Gerjon, Wolthuis, Albert, de Lacy, Francisco B., Lefevre, Jérémie H., Solomon, Michael, Frasson, Matteo, Rotholtz, Nicolas, Denost, Quentin, Perez, Rodrigo O., Konishi, Tsuyoshi, Panis, Yves, Rutegård, Martin, Hompes, Roel, Rosman, Camiel, van Workum, Frans, Tanis, Pieter J., de Wilt, Johannes H.W., Bremers, Andreas J.A., Ferenschild, Floris T., de Vriendt, Stefanie, D’Hoore, André, Bislenghi, Gabriele, Farguell, Jordi, Lacy, Antonio M., Atienza, Paula González, van Kessel, Charlotte S., Parc, Yann, Voron, Thibault, Collard, Maxime K., Muriel, Jorge Sancho, Cholewa, Hannia, Mattioni, Laura A., Frontali, Alice, Polle, Sebastiaan W., Polat, Fatih, Obihara, Ndidi J., Vailati, Bruna B., Kusters, Miranda, Tuynmann, Jurriaan B., Hazen, Sanne J.A., Grüter, Alexander A.J., Amano, Takahiro, Fujiwara, Hajime, Salomon, Mario, Ruiz, Hernán, Gonzalez, Ricardo, Estefanía, Diego, Avellaneda, Nicolas, Carrie, Augusto, Santillan, Mateo, Pantoja Pachajoa, Diana A., Parodi, Matias, Gielis, Manuel, Binder, Alf-Dorian, Gürtler, Thomas, Riedl, Peter, Badiani, Sarit, Berney, Christophe, Morgan, Matthew, Hollington, Paul, da Silva, Nigel, Nair, Gavin, Ho, Yiu M., Lamparelli, Michael, Kapadia, Raj, Kroon, Hidde M., Dudi-Venkata, Nagendra N., Liu, Jianliang, Sammour, Tarik, Flamey, Nicolas, Pattyn, Paul, Chaoui, Ahmed, Vansteenbrugge, Louis, van den Broek, Nathalie E.J., Vanclooster, Patrick, de Gheldere, Charles, Pletinckx, Pieter, Defoort, Barbara, Dewulf, Maxime, Slavchev, Mihail, Belev, Nikolay, Atanasov, Boyko, Krastev, Panche, Sokolov, Manol, Maslyankov, Svilen, Gribnev, Petar, Pavlov, Vasil, Ivanov, Tsvetomir, Karamanliev, Martin, Filipov, Emil, Tonchev, Pencho, Aigner, Felix, Mitteregger, Martin, Allmer, Caterina, Seitinger, Gerald, Colucci, Nicola, Buchs, Nicolas, Ris, Frédéric, Toso, Christian, Gialamas, Eleftherios, Vuagniaux, Aurélie, Chautems, Roland, Sauvain, Marc-Olivier, Daester, Silvio, von Flüe, Markus, Guenin, Marc-Olivier, Taha-Mehlitz, Stephanie, Hess, Gabriel F., Martínek, Lubomír, Skrovina, Matej, Machackova, Maria, Benčurik, Vladimir, Uluk, Deniz, Pratschke, Johann, Dittrich, Luca S., Guel-Klein, Safak, Perez, Daniel, Grass, Julia-Kristin, Melling, Nathaniel, Mueller, Simone, Iversen, Lene H., Eriksen, Jacob D., Baatrup, Gunnar, Al-Najami, Issam, Bjørsum-Meyer, Thomas, Teras, Jüri, Teras, Roland M., Monib, Fatma A., Abu Elnga Ahmed, Nagm Eldin, Alkady, Eithar, Ali, Ahmed K., Khedr, Gehan Abd Elatti, Abdelaal, Ahmed Samir, Bassyouni Ashoush, Fouad M., Ewedah, Moataz, Elshennawy, Eslam M., Hussein, Mohamed, Fernández-Martínez, Daniel, García-Flórez, Luis J., Fernández-Hevia, María, Suárez-Sánchez, Aida, del Hoyo Aretxabala, Izaskun, Docampo, Iria Losada, Zabala, Jesús Gómez, Tejedor, Patricia, Morales Bernaldo de Quirós, Javier T., Quiroga, Ignacio Bodega, Navarro-Sánchez, Antonio, Darias, Iván Soto, Fernández, Cristina López, de La Cruz Cuadrado, Cristina, Sánchez-Guillén, Luis, López-Rodríguez-Arias, Francisco, Soler-Silva, Álvaro, Arroyo, Antonio, Bernal-Sprekelsen, Juan C., Gómez-Abril, Segundo Á., Gonzálvez, Paula, Torres, María T., Sánchez, Teresa Rubio, Antona, Francisco Blanco, Sánchez Lara, Juan E., Alcázar Montero, José A., Fernández-Martínez, Daniel, García-Flórez, Luis J., Fernández-Hevia, María, Suárez-Sánchez, Aida, Colás-Ruiz, Enrique, Tasende-Presedo, Marta M., Fernández-Hurtado, Ignacio, Cifuentes-Ródenas, José A., Suárez, Marta Castro, Losada, Manuel, Hernández, Miguel, Alonso, Alfredo, Diéguez, Beatriz, Serralta, Daniel, Medina Quintana, Rita E., Gil Lopez, Jose M., Pinto, Francisca Lima, Nieto-Moreno, Elena, Bonito, Alba Correa, Santacruz, Carlos Cerdán, Marcos, Elena Bermejo, Septiem, Javier García, Calero-Lillo, Aránzazu, Alanez-Saavedra, Javier, Muñoz-Collado, Salvador, López-Lara, Manuel, Martínez, María Labalde, Herrero, Eduardo Ferrero, Borda, Francisco Javier García, Villar, Óscar García, Escartín, Jorge, Blas, Juan L., Ferrer, Rocío, Egea, Jorge García, Rodríguez-Infante, Antonio, Mínguez-Ruiz, Germán, Carreño-Villarreal, Guillermo, Pire-Abaitua, Gerardo, Dziakova, Jana, Rodríguez, Carlos Sáez-Cazallas, Pizarro Aranda, María J., Muguerza Huguet, José M., Borda-Arrizabalaga, Nerea, Enriquez-Navascués, José M., Echaniz, Garazi Elorza, Ansorena, Yolanda Saralegui, Estaire-Gómez, Mercedes, Martínez-Pinedo, Carlos, Barbero-Valenzuela, Alejandro, Ruíz-García, Pablo, Kraft, Miquel, Gómez-Jurado, María J., Pellino, Gianluca, Espín-Basany, Eloy, Cotte, Eddy, Panel, Nathalie, Goutard, Claire-Angéline, deÁngelis, Nicola, Lauka, Lelde, Shaikh, Shafaque, Osborne, Laura, Ramsay, George, Nichita, Vladimir-Ion, Bhandari, Santosh, Sarmah, Panchali, Bethune, Rob M., Pringle, Heather C.M., Massey, Lisa, Fowler, George E., Hamid, Hytham K.S., de Simone, Belinda D., Kynaston, James, Bradley, Nicholas, Stienstra, Roxane M., Gurjar, Shashank, Mukherjee, Tanmoy, Chandio, Ashfaq, Ahmed, Safia, Singh, Baljit, Runau, Francois, Chaudhri, Sanjay, Siaw, Oliver, Sarveswaran, Janahan, Miu, Victor, Ashmore, Daniel, Darwich, Haitham, Singh-Ranger, Deepak, Singh, Nirbhaibir, Shaban, Mohamed, Gareb, Fahed, Petropolou, Thalia, Polydorou, Adreas, Dattani, Mit, Afzal, Asma, Bavikatte, Akshay, Sebastian, Boby, Ward, Nicholas, Mishra, Amitabh, Manatakis, Dimitrios, Agalianos, Christos, Tasis, Nikolaos, Antonopoulou, Maria-Ioanna, Karavokyros, Ioannis, Charalabopoulos, Alexandros, Schizas, Dimitrios, Baili, Efstratia, Syllaios, Athanasios, Karydakis, Lysandros, Vailas, Michail, Balalis, Dimitrios, Korkolis, Dimitrios, Plastiras, Aris, Rompou, Aliki, Xenaki, Sofia, Xynos, Evangelos, Chrysos, Emmanuel, Venianaki, Maria, Christodoulidis, Grigorios, Perivoliotis, Konstantinos, Tzovaras, George, Baloyiannis, Ioannis, Ho, Man-Fung, Ng, Simon Siu-man, Mak, Tony Wing-chung, Futaba, Kaori, Šantak, Goran, Šimleša, Damir, osić, Jurica, Zukanović, Goran, Kelly, Michael E., Larkin, John O., McCormick, Paul H., Mehigan, Brian J., Connelly, Tara M., Neary, Peter, Ryan, Jessica, McCullough, Peter, Al-Juaifari, Maytham A., Hammoodi, Hayder, Abbood, Ali Hashim, Calabrò, Marcello, Muratore, Andrea, Terra, Antonio La, Farnesi, Francesca, Feo, Carlo V., Fabbri, Nicolò, Pesce, Antonio, Fazzin, Marta, Roscio, Francesco, Clerici, Federico, Lucchi, Andrea, Vittori, Laura, Agostinelli, Laura, Ripoli, Maria Cristina, Sambucci, Daniele, Porta, Andrea, Sinibaldi, Giovanni, Crescentini, Giacomo, larcinese, Antonella, Picone, Emanuele, Persiani, Roberto, Biondi, Alberto, Pezzuto, Roberto, Lorenzon, Laura, Rizzo, Gianluca, Coco, Claudio, D’Agostino, Luca, Spinelli, Antonino, Sacchi, Matteo M., Carvello, Michele, Foppa, Caterina, Spinelli, Antonino, Sacchi, Matteo M., Carvello, Michele, Foppa, Caterina, Maroli, Annalisa, Palini, Gian M., Garulli, Gianluca, Zanini, Nicola, Delrio, Paolo, Rega, Daniela, Carbone, Fabio, Aversano, Alessia, Pirozzolo, Giovanni, Recordare, Alfonso, DʼAlimonte, Lucrezia, Vignotto, Chiara, Corbellini, Carlo, Sampietro, Gianluca M., Lorusso, Leonardo, Manzo, Carlo A., Ghignone, Federico, Ugolini, Giampaolo, Montroni, Isacco, Pasini, Franceso, Pasini, Francesco, Ballabio, Michele, Bisagni, Pietro, Armao, Francesca T., Longhi, Marco, Ghazouani, Omar, Galleano, Raffaele, Tamini, Nicolò, Oldani, Massimo, Nespoli, Luca, Picciariello, Arcangelo, Altomare, Donato F., Tomasicchio, Giovanni, Lantone, Giuliano, Catena, Fausto, Giuffrida, Mario, Annicchiarico, Alfredo, Perrone, Gennaro, Grossi, Ugo, Santoro, Giulio A., Zanus, Giacomo, Iacomino, Alessandro, Novello, Simone, Passuello, Nicola, Zucchella, Martino, Puca, Lucia, deGiuli, Maurizio, Reddavid, Rossella, Scabini, Stefano, Aprile, Alessandra, Soriero, Domenico, Fioravanti, Emanuela, Rottoli, Matteo, Romano, Angela, Tanzanu, Marta, Belvedere, Angela, Mariani, Nicolò M., Ceretti, Andrea P., Opocher, Enrico, Gallo, Gaetano, Sammarco, Giuseppe, de Paola, Gilda, Pucciarelli, Salvatore, Marchegiani, Francesco, Spolverato, Gaya, Buzzi, Gianluca, Di Saverio, Salomone, Meroni, Paola, Parise, Cristiano, Bottazzoli, Elisa I., Lapolla, Pierfrancesco, Brachini, Gioia, Cirillo, Bruno, Mingoli, Andrea, Sica, Giuseppe, Siragusa, Leandro, Bellato, Vittoria, Cerbo, Daniele, de Pasqual, Carlo A., de Manzoni, Giovanni, di Cosmo, Maria A., Alrayes, Bourhan M.H., Qandeel, Mahmoud W. M., Hani, Mohammad Bani, Rabadi, Alexander, el Muhtaseb, Mohammad S., Abdeen, Basel, Karmi, Fahed, Žilinskas, Justas, Latkauskas, Tadas, Tamelis, Algimantas, Pikūnienė, Ingrida, Šlenfuktas, Vygintas, Poskus, Tomas, Kryzauskas, Marius, Jakubauskas, Matas, Mikalauskas, Saulius, Jakubauskiene, Lina, Hassan, Soha Y., Altrabulsi, Amani, Abdulwahed, Eman, Ghmagh, Reem, Deeknah, Abdulqudus, Alshareea, Entisar, Elhadi, Muhammed, Abujamra, Saleh, Msherghi, Ahmed A., Tababa, Osama W.E., Majbar, Mohammed A., Souadka, Amine, Benkabbou, Amine, Mohsine, Raouf, Echiguer, Sabrillah, Moctezuma-Velázquez, Paulina, Salgado-Nesme, Noel, Vergara-Fernández, Omar, Sainz-Hernández, Juan C., Alvarez-Bautista, Francisco E., Zakaria, Andee D., Zakaria, Zaidi, Wong, Michael P.K., Ismail, Razif, Ibrahim, Aini F., Abdullah, Nik A.N., Julaihi, Rokayah, Bhat, Sameer, OʼGrady, Greg, Bissett, Ian, Lamme, Bas, Musters, Gijsbert D., Dinaux, Anne M., Grotenhuis, Brechtje A., Steller Arend G.J. Aalbers, Ernst J., Leeuwenburgh, Marjolein M., Rutten, Harm J.T., Burger, Jacobus W.A., Bloemen, Johanne G., Ketelaers, Stijn H.J., Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, Talsma, Aaldert K., Scheurink, Lieke, van Praagh, Jasper B., Segelman, Josefin, Nygren, Jonas, Anderin, Kajsa, Tiefenthal, Marit, de Andrés, Beatriz, Beltrán de Heredia, Juan P., Vázquez, Andrea, Gómez, Tania, Golshani, Parisa, Kader, Rawaz, Mohamed, Abudi, Westerterp, Marinke, Marinelli, Andreas, Niemer, Quirine, Doornebosch, Pascal G., Shapiro, Joël, Vermaas, Maarten, de Graaf, Eelco J.R., van Westreenen, Hendrik L., Zwakman, Marije, van Dalsen, Annette D., Vles, Wouter J., Nonner, Joost, Toorenvliet, Boudewijn R., Janssen, Paul T.J., Verdaasdonk, Emiel G.G., Amelung, Femke J., Peeters Renu R. Bahadoer, Koen C.M.J., Holman, Fabian A., Heemskerk, Jeroen, Vosbeek, Noortje, Leijtens, Jeroen W.A., Taverne, Sophie B.M., Heijnen, Bob H.M., El-Massoudi, Youssef, de Groot-van Veen, Irene, Hoff, Christiaan, Jou-Valencia, Daniela, Consten, Esther C.J., Burghgraef, Thijs A., Geitenbeek, Ritch, Hulshof, Lorenzo G.W.L., Slooter, Gerrit D., Reudink, Muriël, Bouvy, Nicole D., Wildeboer, Aurelia C. L., Verstappen, Sonja, Pennings, Alexander J., van den Hengel, Berber, Wijma, Allard G., de Haan, Jael, de Nes, Lindsey C.F., Heesink, Vera, Karsten, Tom, Heidsma, Charlotte M., Koemans, Willem J., Dekker, Jan-Willem T., van der Zijden, Charlène J., Roos, Daphne, Demirkiran, Ahmet, van der Burg, Sjirk, Oosterling, Steven J., Hoogteijling, Tijs J., Wiering, Bastiaan, Smeeing, Diederik P.J., Havenga, Klaas, Lutfi, Hamid, Consten, Esther C.J., Tsimogiannis, Konstantinos, Sköldberg, Filip, Folkesson, Joakim, den Boer, Frank, van Schaik, Ted G., van Gerven, Pieter, Sietses, Colin, Hol, Jeroen C., Boerma, Evert-Jan G., Creemers, Davy M.J., Schultz, Johannes K., Frivold, Tone, Riis, Rolf, Gregussen, Hilde, Busund, Sondre, Sjo, Ole H., Gaard, Maria, Krohn, Nina, Ersryd, Amanda L., Leung, Edmund, Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, Sultan, Hytham, Hajjaj, Baraa Nabil, Alhisi, Ahmed Jehad, Khader, Ahmed A.E., Mendes, Ana Filipa Dias, Semião, Miguel, Faria, Luis Queiroz, Azevedo, Constança, da Costa Devesa, Helena M., Martins, Sónia Fortuna, Rodrigues Jarimba, Aldo M., Ribeiro Marques, Sónia M., Ferreira, Rita Marques, Oliveira, António, Ferreira, Cátia, Pereira, Ricardo, Surlin, Valeriu M., Graure, Giorgiana M., Ramboiu, Stefan Patrascu Sandu D., Negoi, Ionut, Ciubotaru, Cezar, Stoica, Bogdan, Tanase, Ioan, Stoica, Bogdan, Ciubotaru, Cezar, Negoita, Valentina M., Florea, Sabrina, Macau, Florin, Vasile, Mihai, Stefanescu, Victor, Dimofte, Gabriel-Mihail, Luncă, Sorinel, Roată, Cristian-Ene, Mu[Latin Small Letter s with comma below]ină, Ana-Maria, Garmanova, Tatiana, Agapov, Mikhail N., Markaryan, Daniil G., Eduard, Galliamov, Yanishev, Alexey, Abelevich, Alexander, Bazaev, Andrey, Rodimov, Sergey V., Filimonov, Victor B., Melnikov, Andrey A., Suchkov, Igor A., Drozdov, EvgeniyS., Kostromitskiy, Dmitriy N., Sjöström, Olle, Matthiessen, Peter, Baban, Bayar, Gadan, Soran, Jadid, Kaveh Dehlaghi, Staffan, Maria, Park, Jennifer M., Rydbeck, Daniel, Lydrup, Marie-Louise, Buchwald, Pamela, Jutesten, Henrik, Darlin, Lotten, Lindqvist, Ebba, Nilsson, Karl, Larsson, Per-Anders, Jangmalm, Staffan, Košir, Jurij A., Tomažič, Aleš, Grosek, Jan, Božič, Tajda Košir, Zazo, Aya, Zazo, Rama, Fares, Hala, Ayoub, Kusay, Niazi, Ammar, Mansour, Ali, Abbas, Ayman, Tantoura, Mohammad, Hamdan, Alaa, Hassan, Naya, Hasan, Bassam, Saad, Ahmad, Sebai, Amine, Haddad, Anis, Maghrebi, Houcine, Kacem, Montasser, Yalkın, Ömer, Samsa, Mehmet Veysi, Atak, İbrahim, Balci, Bengi, Haberal, Elifcan, Dogan, Lütfi, Gecim, Ibrahim E., Akyol, Cihangir, Koc, Mehmet A., Sivrikoz, Emre, Piyadeoğlu, Deniz, Larkin, John O., avanagh, Dara O., Sökmen, Selman, Bişgin, Tayfun, Günenç, Erşan, Güzel, Melek, Leventoğlu, Sezai, Yüksel, Osman, Kozan, Ramazan, Göbüt, Hüseyin, Cengiz, Fevzi, Erdinc, Kemal, Acar, Nihan Coşgun, Kamer, Erdinc, Özgür, İlker, Aydın, Oguzhan, Keskin, Metin, Bulut, Mehmet Türker, Kulle, Cemil B., Kara, Yasin, Sıbıç, Osman, Özata, İbrahim H., Buğra, Dursun, Balık, Emre, Kulle, Cemil B., Çakır, Murat, Alhardan, Anas, Colak, Elif, CiftciEngin Aybar, Ahmet B., Sari, Ahmet Can, Atici, Semra Demirli, Kaya, Tayfun, Dursun, Ayberk, Calik, Bulent, Özkan, Ömer Faruk, Ülgür, Hanife Şeyda, Düzgün, Özgül, Monson, John, George, Sarah, Woods, Kayla, Al-Eryani, Fatima, Albakry, Rudaina, Coetzee, Emile, Boutall, Adam, Herman, Ayesiga, Warden, Claire, Mugla, Naser, Forgan, Tim, Mia, Imraan, and Lambrechts, Anton

Published
2023
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15. A fixed-target programme at the LHC for heavy-ion, hadron, spin and astroparticle physics: AFTER@LHC

Author

Kikoła, D., Brodsky, S. J., Cavoto, G., Da Silva, C., Donato, F., Echevarria, M. G., Ferreiro, E. G., Hadjidakis, C., Hřivnáčová, I., Klein, A., Kurepin, A., Kusina, A., Lansberg, J. P., Lorcé, C., Lyonnet, F., Makdisi, Y., Massacrier, L., Porteboeuf, S., Quintans, C., Rakotozafindrabe, A., Robbe, P., Scandale, W., Schienbein, I., Seixas, J., Shao, H. S., Signori, A., Topilskaya, N., Trzeciak, B., Uras, A., Wagner, J., Yamanaka, N., Yang, Z., and Zelenski, A.

Subjects
Nuclear Experiment
Abstract

Thanks to its multi-TeV LHC proton and lead beams, the LHC complex allows one to perform the most energetic fixed-target experiments ever and to study with high precision pp, pd and pA collisions at sqrt(s_NN) = 115 GeV and Pbp and PbA collisions at sqrt(s_NN) = 72 GeV. We present a selection of feasibility studies for the production of quarkonia, open heavy-flavor mesons as well as light-flavor hadrons in pA and PbA collisions using the LHCb and ALICE detectors in a fixed-target mode., Comment: Proceedings of the Quark Matter 2018 conference

Published
2018
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16. Letter of Intent: A New QCD facility at the M2 beam line of the CERN SPS (COMPASS++/AMBER)

Author

Adams, B., Aidala, C. A., Akhunzyanov, R., Alexeev, G. D., Alexeev, M. G., Amoroso, A., Andrieux, V., Anfimov, N. V., Anosov, V., Antoshkin, A., Augsten, K., Augustyniak, W., Azevedo, C. D. R., Azhibekov, A., Badelek, B., Balestra, F., Ball, M., Barth, J., Beck, R., Bedfer, Y., Antequera, J. Berenguer, Bernauer, J. C., Bernhard, J., Bodlak, M., Bordalo, P., Bradamante, F., Bressan, A., Buchele, M., Burtsev, V. E., Chang, W. -C., Chatterjee, C., Chen, X., Chiosso, M., Chumakov, A. G., Chung, S. -U., Cicuttin, A., Correia, P., Crespo, M. L., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Dashyan, N., Denisenko, I., Denisov, O. Yu., Dhara, L., d'Hose, N., Donato, F., Donskov, S. V., Doshita, N., Dreisbach, Ch., Dunnweber, W., Dusaev, R. R., Dziewiecki, M., Dzyuba, A., Efremov, A., Egelhof, P., Elagin, A., Eversheim, P. D., Faessler, M., Fedotova, J., Ferrero, A., Finger, M., Finger Jr., M., Fischer, H., Franco, C., Friedrich, J. M., Frolov, V., Futch, A., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Gevorkyan, S., Ghandilyan, Y., Giarra, J., Gnesi, I., Gorzellik, M., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Gushterski, R. I., Guskov, A., Hahne, D., Hamar, G., von Harrach, D., He, X., Heitz, R., Herrmann, F., Horikawa, N., Hsieh, C. -Y., Huber, S., Inglessi, A., Ilyichev, A., Isataev, T., Ishimoto, S., Ivanov, A., Ivanov, N., Ivanshin, Yu., Iwata, T., Jandek, M., Jary, V., Jen, C. -M., Joosten, R., Joerg, P., Juraskova, K., Kabuss, E., Kabyshev, A., Kaspar, F., Kerbizi, A., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kim, M., Kiselev, O., Kisselev, Yu., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O. M., Koval, A., Kral, Z., Kraemer, M., Krinner, F., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R. P., Kuterbekov, K., Kuznetsov, I. I., Kveton, A., Levchenko, E. A., Levorato, S., Lian, Y. -S., Liang, Y., Lichtenstadt, J., Lin, P. -J., Liu, K., Liu, M. X., Longo, R., Lorenzon, W., Losekamm, M., Lyubovitskij, V. E., Maev, E., Maggiora, A., Magnon, A., Makarenko, V., Makins, N., Makke, N., Mallot, G. K., Maltsev, A., Mamon, S. A., Marianski, B., Martin, A., Marukyan, H., Marzec, J., Masi, N., Matousek, J., Matsuda, H., Mattson, G., Meshcheryakov, G. V., Meyer, W., Meyer, M., Mikhailov, Yu. V., Mikhasenko, M., Minot, M., Mitrofanov, E., Mitrofanov, N., Miyachi, Y., Moretti, A., Nagaytsev, A., Naim, C., Neyret, D., Nigmatkulov, G., Mkrtchyan, A., Mkrtchyan, H., Novy, J., Nowak, W. -D., Nozzoli, F., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Osborn, J. D., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Peshekhonov, D. V., Pesek, M., Peskova, M., Pierre, N., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Poeschl, T., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Raymond, R., Reicherz, G., Riedl, C., Ryabchikov, D. I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V. D., Sandacz, A., Sarkar, S., Sarsour, M., Savin, I. A., Sbrizzai, G., Schmieden, H., Seder, E., Selyunin, A., Simon, H., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Srnka, A., Steffen, D., Stolarski, M., Subrt, O., Sulc, M., Suzuki, H., Szabelski, A., Sznajder, P., Tasevsky, M., Tchekhovski, V., Tessaro, S., Tessarotto, F., Thiel, A., Tomsa, J., Tosello, F., Tskhay, V., Uhl, S., Vasilishin, B. I., Vassiliev, A., Vauth, A., Veit, B. M., Ventura, B., Veloso, J., Vidon, A., Virius, M., Vorobyev, A., Wagner, M., Wallner, S., Wilfert, M., Xiao, Z., Xu, N., Yang, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., Zhao, H., Zhao, Y., Zhuravlev, N., Ziembicki, M., and Zuccon, P.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

A New QCD facility at the M2 beam line of the CERN SPS COMPASS++/AMBER, Comment: 91 pages, 51 figures

Published
2018

17. A Fixed-Target Programme at the LHC: Physics Case and Projected Performances for Heavy-Ion, Hadron, Spin and Astroparticle Studies

Author

Hadjidakis, C., Kikoła, D., Lansberg, J. P., Massacrier, L., Echevarria, M. G., Kusina, A., Schienbein, I., Seixas, J., Shao, H. S., Signori, A., Trzeciak, B., Brodsky, S. J., Cavoto, G., Da Silva, C., Donato, F., Ferreiro, E. G., Hrivnacova, I., Klein, A., Kurepin, A., Lyonnet, F., Makdisi, Y., Lorcé, C., Porteboeuf, S., Quintans, C., Rakotozafindrabe, A., Robbe, P., Topilskaya, N., Uras, A., Wagner, J., Yamanaka, N., Yang, Z., and Zelenski, A.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment, Nuclear Theory
Abstract

We review the context, the motivations and the expected performances of a comprehensive and ambitious fixed-target program using the multi-TeV proton and ion LHC beams. We also provide a detailed account of the different possible technical implementations ranging from an internal wire target to a full dedicated beam line extracted with a bent crystal. The possibilities offered by the use of the ALICE and LHCb detectors in the fixed-target mode are also reviewed., Comment: LaTeX, 115 pages. v2: version submitted to Physics Reports. A few figures added and some text improved. v3: accepted for publication in Physics Reports

Published
2018
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20. Statistical Measurement of the Gamma-ray Source-count Distribution as a Function of Energy

Author

Zechlin, H. -S., Cuoco, A., Donato, F., Fornengo, N., and Regis, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Photon counts statistics have recently been proven to provide a sensitive observable for characterizing gamma-ray source populations and for measuring the composition of the gamma-ray sky. In this work, we generalize the use of the standard 1-point probability distribution function (1pPDF) to decompose the high-latitude gamma-ray emission observed with Fermi-LAT into: (i) point-source contributions, (ii) the Galactic foreground contribution, and (iii) a diffuse isotropic background contribution. We analyze gamma-ray data in five adjacent energy bands between 1 and 171 GeV. We measure the source-count distribution dN/dS as a function of energy, and demonstrate that our results extend current measurements from source catalogs to the regime of so far undetected sources. Our method improves the sensitivity for resolving point-source populations by about one order of magnitude in flux. The dN/dS distribution as a function of flux is found to be compatible with a broken power law. We derive upper limits on further possible breaks as well as the angular power of unresolved sources. We discuss the composition of the gamma-ray sky and capabilities of the 1pPDF method., Comment: 4 pages, 2 figures. Proceedings, 6th International Symposium on High-Energy Gamma-Ray Astronomy (Gamma2016), Heidelberg, Germany, July 11-15, 2016

Published
2017
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21. Anal Fistulas

Author

Altomare, Donato F., Marino, Fabio, Lobascio, Pierluigi, De Fazio, Michele, Lumley, J. S. P., Series Editor, Howe, James R., Series Editor, Hohenberger, Werner, editor, and Parker, Michael, editor

Published
2021
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26. Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer

Author

Emanuela Guerra, Marco Trerotola, Valeria Relli, Rossano Lattanzio, Romina Tripaldi, Giovanna Vacca, Martina Ceci, Khouloud Boujnah, Valeria Garbo, Antonino Moschella, Romina Zappacosta, Pasquale Simeone, Robert de Lange, Ulrich H. Weidle, Maria Teresa Rotelli, Arcangelo Picciariello, Raffaella Depalo, Patrizia Querzoli, Massimo Pedriali, Enzo Bianchini, Domenico Angelucci, Giuseppe Pizzicannella, Carla Di Loreto, Mauro Piantelli, Laura Antolini, Xiao-Feng Sun, Donato F. Altomare, and Saverio Alberti

Subjects
E-cadherin, β-catenin, Trop-2, proteolytic cleavage, Metastasis, Signaling networks, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

We recently reported that activation of Trop-2 through its cleavage at R87-T88 by ADAM10 underlies Trop-2–driven progression of colon cancer. However, the mechanism of action and pathological impact of Trop-2 in metastatic diffusion remain unexplored. Through searches for molecular determinants of cancer metastasis, we identified TROP2 as unique in its up-regulation across independent colon cancer metastasis models. Overexpression of wild-type Trop-2 in KM12SM human colon cancer cells increased liver metastasis rates in vivo in immunosuppressed mice. Metastatic growth was further enhanced by a tail-less, activated ΔcytoTrop-2 mutant, indicating the Trop-2 tail as a pivotal inhibitory signaling element. In primary tumors and metastases, transcriptome analysis showed no down-regulation of CDH1 by transcription factors for epithelial-to-mesenchymal transition, thus suggesting that the pro-metastatic activity of Trop-2 is through alternative mechanisms. Trop-2 can tightly interact with ADAM10. Here, Trop-2 bound E-cadherin and stimulated ADAM10-mediated proteolytic cleavage of E-cadherin intracellular domain. This induced detachment of E-cadherin from β-actin, and loss of cell-cell adhesion, acquisition of invasive capability, and membrane-driven activation of β-catenin signaling, which were further enhanced by the ΔcytoTrop-2 mutant. This Trop-2/E-cadherin/β-catenin program led to anti-apoptotic signaling, increased cell migration, and enhanced cancer-cell survival. In patients with colon cancer, activation of this Trop-2–centered program led to significantly reduced relapse-free and overall survival, indicating a major impact on progression to metastatic disease. Recently, the anti-Trop-2 mAb Sacituzumab govitecan-hziy was shown to be active against metastatic breast cancer. Our findings define the key relevance of Trop-2 as a target in metastatic colon cancer.

Published
2021
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27. Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer

Author

Guerra, Emanuela, Trerotola, Marco, Relli, Valeria, Lattanzio, Rossano, Tripaldi, Romina, Vacca, Giovanna, Ceci, Martina, Boujnah, Khouloud, Garbo, Valeria, Moschella, Antonino, Zappacosta, Romina, Simeone, Pasquale, de Lange, Robert, Weidle, Ulrich H., Rotelli, Maria Teresa, Picciariello, Arcangelo, Depalo, Raffaella, Querzoli, Patrizia, Pedriali, Massimo, Bianchini, Enzo, Angelucci, Domenico, Pizzicannella, Giuseppe, Di Loreto, Carla, Piantelli, Mauro, Antolini, Laura, Sun, Xiao-Feng, Altomare, Donato F., and Alberti, Saverio

Published
2021
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29. A fixed-target programme at the LHC: Physics case and projected performances for heavy-ion, hadron, spin and astroparticle studies

Author

Hadjidakis, C., Kikoła, D., Lansberg, J.P., Massacrier, L., Echevarria, M.G., Kusina, A., Schienbein, I., Seixas, J., Shao, H.S., Signori, A., Trzeciak, B., Brodsky, S.J., Cavoto, G., Da Silva, C., Donato, F., Ferreiro, E.G., Hřivnáčová, I., Klein, A., Kurepin, A., Lorcé, C., Lyonnet, F., Makdisi, Y., Porteboeuf Houssais, S., Quintans, C., Rakotozafindrabe, A., Robbe, P., Scandale, W., Topilskaya, N., Uras, A., Wagner, J., Yamanaka, N., Yang, Z., and Zelenski, A.

Published
2021
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30. High precision particle astrophysics as a new window on the universe with an Antimatter Large Acceptance Detector In Orbit (ALADInO)

Author

Battiston, R., Bertucci, B., Adriani, O., Ambrosi, G., Baudouy, B., Blasi, P., Boezio, M., Campana, D., Derome, L., De Mitri, I., Di Felice, V., Donato, F., Duranti, M., Formato, V., Grasso, D., Gebauer, I., Iuppa, R., Masi, N., Maurin, D., Mazziotta, M. N., Musenich, R., Nozzoli, F., Papini, P., Picozza, P., Pearce, M., Pospíšil, S., Rossi, L., Tomassetti, N., Vagelli, V., and Wu, X.

Published
2021
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31. Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey

Author

Shalaby, M, Elsheikh, A, Hamed, H, Null, N, Elsheik, A, Sakr, A, Fouad, A, Kassem, A, Elfeki, H, Madbouly, K, Alzahrani, K, Marzouk, K, Ali, M, Helal, M, Elsorogy, M, Farid, M, Di Lorenzo, N, Sileri, P, Wexner, S, Khafagy, W, Adeyeye, A, El-Hussuna, A, Frontali, A, Saklani, A, Lelpo, B, Molena, D, Pandey, D, Karbovnichaya, E, Pata, F, Van Ramshor, G, Gallo, G, Spolverato, G, Pellino, G, Bagaglini, G, Rubio-Perez, I, Negoi, I, Frigerio, I, Juloski, J, Ninkovic, M, Franceschilli, M, Azer, M, Efetov, S, Ippoliti, S, Garoufalia, Z, Fazli, M, Dogjani, A, Cherfa, H, Omar, T, Minoldo, J, Alvarez Gallesio, J, Quesada, M, Bacher, A, Kropshofer, S, Ponholzer, F, Tesik, P, Gehwolf, P, Isci, S, Uranitsch, S, Berchtold, V, Samadov, E, Abualsel, A, Mitul, A, Islam, S, Vanlander, A, Van Praet, C, Van Daele, E, Vanommeslaeghe, H, Stijns, J, Abosi-Appeadu, K, Depuydt, M, Allaeys, M, Yves, V, Colleoni, R, Slavchev, M, Elbahrawy, A, Luc, J, Milford, K, Romic, I, Monti, A, Haydal, A, Klein, M, Ocklind, M, Hadi, S, Alqasaby, A, Elganash, A, Daibes, A, Elsaied, A, Elhattab, A, Lotfy, A, Alnashar, A, Elnour, A, Abdelhalim, A, Abdelhamid, A, Abdellatif, A, Abdelmohsen, A, Abdelrafee, A, Elhawary, A, Zidan, A, Eleshra, A, Elkafoury, A, Ezz, A, Abdelmomen, A, Elkased, A, Fawzy, A, Elkhouly, A, Hemidan, A, Abbas, A, Ismail, A, Attia, A, Farid, A, Elnakash, A, Negida, A, Soliman, A, Taki-Eldin, A, Albadry, A, Sanad, A, Elbatal, A, Elgazar, A, Saleh, A, Fahiem, A, Mohamed, A, Nageeb, A, Elmetwally, A, Alkhalegy, A, El-Wakeel, A, Shemes, A, Fadel, B, Lutfi, B, Ali, D, Abolnasr, K, Gamal, E, Abdallah, E, Ahmed, E, Salem, E, Hamed, E, Elshikh, E, Enad, F, Sarhan, F, Abouelnagah, G, Tagg, G, Atef, G, Shaker, G, Beshir, H, Zakaria, H, Barbary, H, Elgendy, H, Sharaf, H, Elnaghi, H, Elghadban, H, Elzayat, I, Fakhr, I, Sallam, I, Abdelmoneim, I, Elnemr, I, Zewar, K, Elalfy, K, Sabet, K, Mansour, K, Osman, K, Elgaly, M, Shams, M, Abozeid, M, Mohammed, M, Elkatt, M, Samaha, M, Mikhael, M, Khalil, M, 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Ninkovic, Marijana, Franceschilli, Marzia, Azer, Mina, Efetov, Sergey, Ippoliti, Simona, Garoufalia, Zoe, Fazli, Mohammad Rafi, Dogjani, Agron, Cherfa, Harieche Abdennour Abderahim, Omar, Tilioua, Minoldo, Javier, Alvarez Gallesio, José Maria, Quesada, Matias, Bacher, Annica, Kropshofer, Stephan, Ponholzer, Florian, Tesik, Philip, Gehwolf, Philipp, Isci, Sevim, Uranitsch, Stefan, Berchtold, Valeria, Samadov, Elgun, Abualsel, Abdulmenem, Mitul, Ashrarur Rahman, Islam, S. 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K., Hadi, Sabah Anwar, Alqasaby, Abdallah, Elganash, Abdelazim, Daibes, Adel Goda Hussein, Elsaied, Adham, Elhattab, Ahmad, Lotfy, Ahmad, Alnashar, Ahmed, Elnour, Ahmed Abd Elbaset Elsayed Abu, Abdelhalim, Ahmed, Abdelhamid, Ahmed, Abdellatif, Ahmed, Abdelmohsen, Ahmed, Abdelrafee, Ahmed, Elhawary, Ahmed Adel, Zidan, Ahmed Azmy, Eleshra, Ahmed, Elkafoury, Ahmed, Ezz, Ahmed, Abdelmomen, Ahmed Ezzat Elghrieb, Elkased, Ahmed Farag, Fawzy, Ahmed, Elkhouly, Ahmed G., Hemidan, Ahmed Gamal Abouelfetouh Ibrahim, Abbas, Ahmed Hosam Eldin Hasan, Ismail, Ahmed Mahmoud Ahmed, Attia, Ahmed Mohamed, Farid, Ahmed Mohammed, Elnakash, Ahmed Mostafa, Negida, Ahmed, Soliman, Ahmed, Taki-Eldin, Ahmed, Albadry, Ali Almahdy Ali, Sanad, Aly, Elbatal, Amira Alsayed Abdelhai, Elgazar, Amr, Saleh, Amr, Fahiem, Andrew, Mohamed, Anwar Yahya A., Nageeb, Ashraf, Elmetwally, Ashraf S., Alkhalegy, Ayman, El-Wakeel, Ayman, Shemes, Ayman, Fadel, Bashir A., Lutfi, Basma Waseem, Ali, Doaa, Abolnasr, Khaled Samir, Gamal, Ehab, Abdallah, Emad, Ahmed, Emad Ali, Salem, Eman Abdalla Mohamed, Hamed, Esmael Ali, Elshikh, Essam, Enad, Farazdaq, Sarhan, Fetoh Alaaeldin Fetoh, Abouelnagah, Galal, Tagg, Gamal Hassan El, Atef, Gehad, Shaker, George Samir Habib, Beshir, Hatem, Zakaria, Hazem M., Barbary, Hesham, Elgendy, Hesham, Sharaf, Hesham, Elnaghi, Hisham, Elghadban, Hosam, Elzayat, Ibrahim, Fakhr, Ibrahim, Sallam, Ibrahim, Abdelmoneim, Ibrahim Tharwat Mohamed, Elnemr, Islam, Zewar, Karem Shahin Mohamed, Elalfy, Khaled, Sabet, Khaled, Mansour, Khaled Yousery Ibrahim, Osman, Khalid Abdalla Abdelgadir, Elgaly, Maher Elesawi Kamel, Shams, Maher, Abozeid, Mahmoud, Mohammed, Mahmoud M., Elkatt, Mahmoud Mohamed, Samaha, Mahmoud Yahia, Mikhael, Marolla Maher Eskander, Khalil, Medhat M. 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A., Alhendawey, Moaaz, Elrefai, Mohamad, Gabr, Mohamed A., Fayed, Mohamed Abdelaziz Mohamed Abdalla M, Abdelmaksoud, Mohamed, Salem, Mohamed Abouelmagd, Mohamed Mohamed, Mohamed Adel, Nabeeh, Mohamed Adel, Elsayed, Mohamed Ahmed Abdelhalim Ahmed, Abdelmonem, Mohamed Ahmed, Ali, Mohamed Anwar Abdel Razik, Eldemery, Mohamed, Elmesery, Mohamed, Fikry, Mohamed, Gharbia, Mohamed, Omar, Mohamed I., Elmoghazy, Mohamed Ibrahim, Ghazala, Mohamed Jomma, Hamed, Mohamed Korayem Fattouh, Metwally, Mohamed, Arnouse, Mohamed Mohamed Hamdy, Amen, Mohamed Mohsen, Amary, Mohamed Mokhtar, Kandel, Mohamed Mosaad, Abuzeid, Mohamed Mostafa, Rabea, Mohamed, Sobh, Mohamed Ramadan, Taman, Mohamed, Fathy, Mohammad, Moustafa, Mohammad Montaser Hassan, Zuhdy, Mohammad, Adel, Mohammed, Alaa, Mohammed, Alawady, Mohammed, Edassy, Mohammed El, Mohammed, Mohammed Mustafa Hassan, Eldesouki, Mohammed Nabil, Salim, Mohammed Said Mahmoud, Sanad, Mohammed, Khalaf, Mohsen George, Henes, Mohsen Michael, Abdelglil, Momen, Mohmmed, Mona Mhmoud, Abdelkhalik, Morsi Mohamed Morsi, Shetiwy, Mosab, Elshazli, Mostafa, Hegazy, Mostafa, Ahmed, Mostafa Mahmoud, Abdelhalim, Mostafa Mohammed, Shahein, Mostafa, Sofan, Mostafa, Hammad, Muhammed Alaa Moukhtar, Ahmad, Mustafa, Milad, Nader, Farouk, Nehal, Eldesouky, Omnia, Mohamed, Omnia Y., Mahadel, Osama Abdel Salam, Gaarour, Osama, Torky, Radwan Abdelsabour, Elhafez, Raheem El-Gohary Abd, Adly, Ramy Magdy, Nageeb, Ramy Mikhael, Hamdi, Salah, Gamal, Sameh, Emile, Sameh Hany, Regal, Samer, Abdelrasheed, Sayed, Elzeftawy, Shady Ahmed, Khashshan, Sohib Mohammed Mohammed, Ashraf, Tamer, Khafagy, Tamer, Nabil, Tamer, Abdelazim, Tarek, Rizk, Tarek Taher, Amr, Wesam, Yousef, Yousef Mohamed, Youssef, Youssef Abdel Aziz, Castaldi, Antonio, Fiore, Antonio, Hasani, Ariola, Mariani, Aurora, Dagorno, Claire, Antonio, D'Alessandro, Izzo, Giuliano, Addari, Giulio, Mangiameli, Giuseppe, Rea, Lo Dico, Pio, Luca, Paci, Marco, Andrea, Police, De Fatico, GSerena, Elvira, Tartaglia, 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Grace, Abiyere, Henry, Oluwasuyi, Ige, George, Ihediwa, Njokanma, Iloba Gabriel, Aremu, Isiaka, Dare, Julius Kolajo, Abdur-Rahman, Lukman, Ahmad, Misbahu Haruna, Oludara, Mobolaji Adewale, Mohammad, Mohammad Aminu, Adeoluwa, Ojajuni, Situ, Oladele, Agbonrofo, Peter, Kewulere, Raji Taofiq, Aliyu, Yakubu, Adebowale, Yusuf, Galala, Ahmed, Rao, Satish, Waleed, Aasma, Inam, Aatif, Shaikh, Abdul Razaque, Qureshi, Ahmad Uzair, Muhammad, Aneeqah Din, Ahmed, Arooj, Kerawala, Asad Ali, Aslam, Mohammad, Mehr, Asma, Javed, Ayesha, Ahmad, Farooq, Majid, Haroon Javaid, Ahmed, Hassan, Daudi, Irfan, Akhtar, Khalid, Niaz, Khurram, Anwer, Mariyah, Amir, Mohammed, Hanif, Muhammad Amir, Asif, Muhammad, Raza, Muhammad Asif, Khokhar, Muhammad Imran, Jameel, Muhammad Khurram, Nasir, Muhammad, Shafique, Muhammad Salman, Ateeb, Mujammad, Nadeem, Munawar, Shah, Rahmat Ullah, Waqar, Shahzad Hussain, Shah, Shahzad Alam, Waseem, Talat, Ghafoor, Tariq, Fatima, Tauseef, Bashir, Umar, Gonzales, Erick Ivan Huaman, Ruiz, Luis Angel Garcia, Freitas, Carla, De Sousa, Xavier, Al-Bahrani, Ahmed, Portela, Carlos Antonio Sanchez, Elgazar, Elsayed Aly, Robles, Eloy Morasen, Khan, Irfan Jan, Jarboa, Lutfi, Khawar, Mahwish, Echevarria, Miguel Jose Pinto, Bashah, Moataz M., Dawdi, Salahaldeen, Musthafa, Shameel, Ali, Syed Muhammad, Ciubotaru, Cezar, Bonci, Eduard-Alexandru, Muresan, Mihai-Stefan, Bogdan, Stoica, Ioan, Tanase, Zubayraeva, Albina, Derinov, Aleksandr, Zakharenko, Alexander, Novikova, Anastasia, Bashlachev, Andrey, Kaldarov, Ayrat, Stanislav, Berelavichus, Gorin, David, Puzenko, Dmitriy, Kazachenko, Ekaterina, Ashimov, Erkin, Medkova, Iuliia, Ignatov, Ivan, Sergeevich, Kochetkov Viktor, Sidorova, Lyudmila, Kiselev, Michail, Danilov, Michail, Aleksandr, Ogoreltsev, Rodimov, Sergey, Garmanovs, Tatiana, Kitsenko, Yury, Valery, Nekoval, Japhet, Ntezamizero, Sibiany, Abdulrahman, Saadeldin, Abdelhalim, Abuosba, Abdelrahman, Alawadhi, Abdulbari Mohammed, Alharbi, Abdulhamid, Althumali, Abdullah, Alghuliga, Abdullah, Alotaibi, Abdullah, Abduraboh, Abdullah Fayez, Kateb, Abdullah, Sindy, Abdullah, Al Eisa, Abdulmohsen, Alotaibi, Abdulrahman, Almulhim, Abdulrhman, Aljawhari, Adel Ali, Abozeid, Ahmad Mahmoud, Saad, Ahmad, Alqarni, Ahmed, Alwan, Ahmed, Alwusaibie, Ahmed, Bafaraj, Ahmed, Eldeeb, Ahmed, Tarabay, Ahmed, Mohammed, Mahfoudh, Alhedaithy, Alhanouf, Almaghrabi, Alhassan Hesham, Abed, Ali Ibrahim Eldawy, Abdullah, Alqahtani Ali, Semilan, Anmar, Farag, Mohamed, Khudhayr, Essa, Hussain, Marwah, Abbas, Ghanem, Alqudaihi, Heba, Abualnaja, Yousra, Shaheen, Abelnasser, Mubarak, Ashraf Abdelazeem Mohamed, Ali, Bandar Idrees A., Alhazmi, Barrag, Hijazi, Bilal Ahmed, Abdulrahman, Chadi, Oyedepo, Charles Olajide, Alzamel, Heythem, Tairab, Elsanousi Ibrahim Sabir, Alsuwaimel, Munir A., Hejazi, Soha, Alnoqaidan, Emad, Alhussien, Fade Ahmed, Jallad, Fadi Sami, Khadwardi, Faisal, Alghamdi, Faisal Saleh, Haddad, Feras, Sauri, Fozan, Alafghani, Haitham, Alfalah, Haitham, Gad, Hamada, 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Nouf, Larbi, Noureddine, Alsallum, Ofays, Suliman, Omar AAbu, Elsherbiny, Osama, Abusalem, Osama, Albalawi, Ibrahim Altedlawi, Abutalib, Raid Abdullah, Alarabi, Rayan, Khan, Roaa Ghazi, Alazzam, Saleh, Alghamdi, Saleh, Alsawat, Salem, Salim, Sami, Alshukr, Sarah, Alzahrani, Saud, Golea, Smain, Alowairdhi, Tumadher, Salman, Usama, Abusiam, Wael, Abualkhair, Wael, Saber, Wael, Tashkandi, Wail, Alhazmi, Waleed, Tashkandi, Waleed, Yassine, Wassim Abou, Alshabi, Yaser Ahmad, Ibrahim, Yaser, Shahin, Yasser, Ibrahim, Yassin, Aljathlany, Yousef, Alnahas, Yousef, Alrashidi, Yousef, Wali, Zubair, Ndong, Abdourahmane, Ba, Mamadou, Faye, Papa Mamadou, Arbutina, Dragana, Milic, Ljiljana, Cuk, Vladica, Hussein, Abdinafic Mohamud, Mccaul, Jeannie, Bertels, Laurie, Pohl, Linda, Arnold, Marion, Mbatani, Nomonde, Oosthuizen, Pj, Rayamajhi, Shreya, Vosloo, Susan, Jooma, Uzair, Landaluce-Olavarria, Aitor, Vázquez-Melero, Alba, Marcos, Alberto, Puerto Puerto, Alejandro, De La Hermosa, Alicia Ruiz, 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Tamburrini, A, Parente, A, Light, A, Diamantopoulou, A, Singh, B, Gurung, B, Frauenfelder, C, Leo, C, Raptis, D, Thakrar, D, Madhuri, T, Tsounaki, E, Garreffa, E, Soggiu, F, Stavrou, G, Ng, H, Tabasi, H, Nasef, H, Kostakis, I, Jeffery, J, Warusavitarne, J, Lund, J, Qurashi, K, Sahnan, K, Tong, K, Orecchia, L, Kaur, M, Zaidi, M, Ganau, M, Curtis, N, Bhatt, N, Machairas, N, Zafar, N, Toma, O, Sarmah, P, Bassuni, M, Davies, J, Shawer, S, Lewis, S, Subramanian, S, Nadeem, U, Njau, A, Tohamy, A, Pakula, A, Simioni, A, Jarvis, B, Skandalakis, G, Hesham, H, Isaiah, I, Villwock, J, Martin, L, Kress, M, Sebelik, M, Lathan, S, Towfigh, S, Holubar, S, Demeester, S, Alshehari, M, Ghabisha, S, Abdulatef, S, Al-Kubati, W, Obadiel, Y, Gots, A, Nakazwe, M, Chipaila, J, Mazingi, D, Shalaby, Mostafa, ElSheikh, Ahmed M., Hamed, Hosam, null, null, Elsheik, Ahmed, Sakr, Ahmad, Fouad, Amgad, Kassem, Amr, Elfeki, Hossam, Madbouly, Khaled, Alzahrani, Khalid H., Marzouk, Khalid, Ali, Mahmoud, Helal, Mohamed Alaa Abdelmoez, Elsorogy, Mohamed, Farid, Mohamed, Di Lorenzo, Nicola, Sileri, Pierpaolo, Wexner, Steven, Khafagy, Wael, Adeyeye, Ademola, El-Hussuna, Alaa, Frontali, Alice, Saklani, Avanish, Lelpo, Benedettao, Molena, Daniela, Pandey, Diwakar, Karbovnichaya, Elena, Pata, Francesco, Van Ramshor, Gabrielle H., Gallo, Gaetano, Spolverato, Gaya, Pellino, Gianluca, Bagaglini, Giulia, Rubio-Perez, Ines, Negoi, Ionut, Frigerio, Isabella, Juloski, Jovan, Ninkovic, Marijana, Franceschilli, Marzia, Azer, Mina, Efetov, Sergey, Ippoliti, Simona, Garoufalia, Zoe, Fazli, Mohammad Rafi, Dogjani, Agron, Cherfa, Harieche Abdennour Abderahim, Omar, Tilioua, Minoldo, Javier, Alvarez Gallesio, José Maria, Quesada, Matias, Bacher, Annica, Kropshofer, Stephan, Ponholzer, Florian, Tesik, Philip, Gehwolf, Philipp, Isci, Sevim, Uranitsch, Stefan, Berchtold, Valeria, Samadov, Elgun, Abualsel, Abdulmenem, Mitul, Ashrarur Rahman, Islam, S. M. Nazmul, Vanlander, Aude, Van Praet, Charles, Van Daele, Elke, Vanommeslaeghe, Hanne, Stijns, Jasper, Abosi-Appeadu, Kessewa, Depuydt, Martijn, Allaeys, Mathias, Yves, Van Nieuwenhove, Colleoni, Ramiro, Slavchev, Mihail, Elbahrawy, Aly, Luc, Jessica G. Y., Milford, Karen, Romic, Ivan, Monti, Alessio, Haydal, Ashraf, Klein, Mads Falk, Ocklind, Miranda E. K., Hadi, Sabah Anwar, Alqasaby, Abdallah, Elganash, Abdelazim, Daibes, Adel Goda Hussein, Elsaied, Adham, Elhattab, Ahmad, Lotfy, Ahmad, Alnashar, Ahmed, Elnour, Ahmed Abd Elbaset Elsayed Abu, Abdelhalim, Ahmed, Abdelhamid, Ahmed, Abdellatif, Ahmed, Abdelmohsen, Ahmed, Abdelrafee, Ahmed, Elhawary, Ahmed Adel, Zidan, Ahmed Azmy, Eleshra, Ahmed, Elkafoury, Ahmed, Ezz, Ahmed, Abdelmomen, Ahmed Ezzat Elghrieb, Elkased, Ahmed Farag, Fawzy, Ahmed, Elkhouly, Ahmed G., Hemidan, Ahmed Gamal Abouelfetouh Ibrahim, Abbas, Ahmed Hosam Eldin Hasan, Ismail, Ahmed Mahmoud Ahmed, Attia, Ahmed Mohamed, Farid, Ahmed Mohammed, Elnakash, Ahmed Mostafa, Negida, Ahmed, Soliman, Ahmed, Taki-Eldin, Ahmed, Albadry, Ali Almahdy Ali, Sanad, Aly, Elbatal, Amira Alsayed Abdelhai, Elgazar, Amr, Saleh, Amr, Fahiem, Andrew, Mohamed, Anwar Yahya A., Nageeb, Ashraf, Elmetwally, Ashraf S., Alkhalegy, Ayman, El-Wakeel, Ayman, Shemes, Ayman, Fadel, Bashir A., Lutfi, Basma Waseem, Ali, Doaa, Abolnasr, Khaled Samir, Gamal, Ehab, Abdallah, Emad, Ahmed, Emad Ali, Salem, Eman Abdalla Mohamed, Hamed, Esmael Ali, Elshikh, Essam, Enad, Farazdaq, Sarhan, Fetoh Alaaeldin Fetoh, Abouelnagah, Galal, Tagg, Gamal Hassan El, Atef, Gehad, Shaker, George Samir Habib, Beshir, Hatem, Zakaria, Hazem M., Barbary, Hesham, Elgendy, Hesham, Sharaf, Hesham, Elnaghi, Hisham, Elghadban, Hosam, Elzayat, Ibrahim, Fakhr, Ibrahim, Sallam, Ibrahim, Abdelmoneim, Ibrahim Tharwat Mohamed, Elnemr, Islam, Zewar, Karem Shahin Mohamed, Elalfy, Khaled, Sabet, Khaled, Mansour, Khaled Yousery Ibrahim, Osman, Khalid Abdalla Abdelgadir, Elgaly, Maher Elesawi Kamel, Shams, Maher, Abozeid, Mahmoud, Mohammed, Mahmoud M., Elkatt, Mahmoud Mohamed, Samaha, Mahmoud Yahia, Mikhael, Marolla Maher Eskander, Khalil, Medhat M. H. A., Alhendawey, Moaaz, Elrefai, Mohamad, Gabr, Mohamed A., Fayed, Mohamed Abdelaziz Mohamed Abdalla M, Abdelmaksoud, Mohamed, Salem, Mohamed Abouelmagd, Mohamed Mohamed, Mohamed Adel, Nabeeh, Mohamed Adel, Elsayed, Mohamed Ahmed Abdelhalim Ahmed, Abdelmonem, Mohamed Ahmed, Ali, Mohamed Anwar Abdel Razik, Eldemery, Mohamed, Elmesery, Mohamed, Fikry, Mohamed, Gharbia, Mohamed, Omar, Mohamed I., Elmoghazy, Mohamed Ibrahim, Ghazala, Mohamed Jomma, Hamed, Mohamed Korayem Fattouh, Metwally, Mohamed, Arnouse, Mohamed Mohamed Hamdy, Amen, Mohamed Mohsen, Amary, Mohamed Mokhtar, Kandel, Mohamed Mosaad, Abuzeid, Mohamed Mostafa, Rabea, Mohamed, Sobh, Mohamed Ramadan, Taman, Mohamed, Fathy, Mohammad, Moustafa, Mohammad Montaser Hassan, Zuhdy, Mohammad, Adel, Mohammed, Alaa, Mohammed, Alawady, Mohammed, Edassy, Mohammed El, Mohammed, Mohammed Mustafa Hassan, Eldesouki, Mohammed Nabil, Salim, Mohammed Said Mahmoud, Sanad, Mohammed, Khalaf, Mohsen George, Henes, Mohsen Michael, Abdelglil, Momen, Mohmmed, Mona Mhmoud, Abdelkhalik, Morsi Mohamed Morsi, Shetiwy, Mosab, Elshazli, Mostafa, Hegazy, Mostafa, Ahmed, Mostafa Mahmoud, Abdelhalim, Mostafa Mohammed, Shahein, Mostafa, Sofan, Mostafa, Hammad, Muhammed Alaa Moukhtar, Ahmad, Mustafa, Milad, Nader, Farouk, Nehal, Eldesouky, Omnia, Mohamed, Omnia Y., Mahadel, Osama Abdel Salam, Gaarour, Osama, Torky, Radwan Abdelsabour, Elhafez, Raheem El-Gohary Abd, Adly, Ramy Magdy, Nageeb, Ramy Mikhael, Hamdi, Salah, Gamal, Sameh, Emile, Sameh Hany, Regal, Samer, Abdelrasheed, Sayed, Elzeftawy, Shady Ahmed, Khashshan, Sohib Mohammed Mohammed, Ashraf, Tamer, Khafagy, Tamer, Nabil, Tamer, Abdelazim, Tarek, Rizk, Tarek Taher, Amr, Wesam, Yousef, Yousef Mohamed, Youssef, Youssef Abdel Aziz, Castaldi, Antonio, Fiore, Antonio, Hasani, Ariola, Mariani, Aurora, Dagorno, Claire, Antonio, D'Alessandro, Izzo, Giuliano, Addari, Giulio, Mangiameli, Giuseppe, Rea, Lo Dico, Pio, Luca, Paci, Marco, Andrea, Police, De Fatico, GSerena, Elvira, Tartaglia, Schuldes, Alejandro Daniel Lira, Rihan, Eslam, Moeslein, Gabriela, Lederhuber, Hans, Botros, Ibram, Jaman, Ismail, Doerner, Johannes, Elseberbihy, John Rezk Hanna, Sherbiny, Kareem El, Ghonim, Mostafa, Mikrish, Amir, Aziz, Mina, Hatm, Mohamed, Archid, Rami, Gendy, Samuel Elkess Morcos, Ahmad, Sufian, Charalabopoulos, Alexandros, Prodromidou, Anastasia, Ioannidis, Argyrios, Mpaili, Eustratia, Boukorou, Garyfallia, Papadopoulos, Georgios, Liakakos, Theodore, Styliani, Vasileiadou, Agrawal, Abhishek, Jain, Amita, Rashid, Arshad, Mehraj, Asif, Brahmachari, Swagata, Lakshmi, Harish Neelamraju, Vishwakarma, Kushagra, Parida, Lalit, Sharma, Meenakshi, Zaieem, Mohammad, Makasarwala, Murtaza, Nittala, Rigved, Kumar, Sanjeev, Vikrantmr, Sharma, Junaid, Sheikh, Khuller, Somyaa, More, Vinal, Ahmed, Abeer Abdul Hameed, Alomieri, Adil, Alhamdany, Arkan Shubber, Del, Muslim Ka, Najm, Ghadah, Lateef, Nawras Falah, Mcnamara, Deborah, Abdelmageed, Mohammed Elkassaby, Majeed, Mudassar, Troci, Albert, Porcu, Alberto, Marano, Alessandra, Di Bartolomeo, Alessandro, Giani, Alessandro, Giardino, Alessandro, Canfora, Alfonso, Balla, Andrea, Barberis, Andrea, Belli, Andrea, Borasi, Andrea, Manetti, Andrea, Mingoli, Andrea, Morini, Andrea, Maurizi, Angela, Marra, Angelo Alessandro, Epifani, Angelo Gabriele, Iossa, Angelo, Parello, Angelo, Guida, Anna, Maffioli, Anna, Scafa, Anthony Kevin, Spinelli, Antonino, Matarangolo, Antonio, Picciariello, Arcangelo, Pirozzi, Brunella, Cirillo, Bruno, Gazia, Carlo, Ratto, Carlo, Foppa, Caterina, Marafante, Chiara, Andrea, Chierici, Tanda, Cinzia, Guerci, Claudio, Don, Cristine, Zigiotto, Daniele, Coniglio, Denise, Sasia, Diego, Visconti, Diego, Altomare, Donato F., Guaitoli, Eleonora, Botteri, Emanuele, Pinotti, Enrico, Martinelli, Fabio, Uggeri, Fabio, Bàmbina, Fabrizio, Falaschi, Federica, Costanzo, Federico, La Torre, Filippo, Milana, Flavio, Abbatini, Francesca, De Lucia, Francesca, Tropeano, Francesca Paola, Colombo, Francesco, Ferrara, Francesco, Litta, Francesco, Carrano, Francesco Maria, Orlando, Francesco, Roscio, Francesco, Selvaggi, Francesco, Giarratano, Gabriella, Pagano, Gianluca, Lisi, Giorgio, Argenio, Giulio, Zancana, Giuseppa, Cavallaro, Giuseppe, Frazzetta, Giuseppe, Mariateresa, Grasso, Sciaudone, Guido, Vella, Ivan, Siragusa, Leandro, Santurro, Letizia, Ferri, Lorenzo, Petagna, Lorenzo, Ferrario, Luca, Pitoni, Ludovica, Pignatelli, Marcello Filograna, Angrisani, Marco, Giugliano, Marco, Inama, Marco, Marino, Marco V., Veltri, Marco, Giuffrida, Maria Carmela, Menna, Maria Paola, Valente, Marina, Rottoli, Matteo, Sacchi, Matteo, Uccelli, Matteo, Rho, Maurizio, Garino, Mauro, Montuori, Mauro, Campanelli, Michela, Zese, Monica, De Falco, Nadia, Cillara, Nicola, Mariani, Nicolò Maria, Tamini, Nicolò, Adorisio, Ottavio, Campennì, Paola, Venturelli, Paolina, Bernante, Paolo, Sapienza, Paolo, Cianci, Pasquale, Marsanic, Patrizia, Lapolla, Pierfrancesco, Tecchio, Piero, Familiari, Pietro, Fransvea, Pietro, Bruzzaniti, Placido, Hassan, Redan, Pirovano, Riccardo, Rimonda, Roberto, Di Saverio, Salomone, Di Carlo, Sara, Perra, Teresa, Campagnaro, Tommaso, Testa, Valentina, Andriola, Valeria, Grappelli, Virgilio Michael Ambrosi, Capizzi, Vita, Chiarella, Vito, Bellato, Vittoria, Yanaga, Katsuhiko, Farouk, Mohamed, Uraiqat, Ahmad, Almasri, Mahmoud, Nabwana, Ambrose, Siboe, Mark M. W., W, Njoroge P., Njoroge, Githu, Ilkul, Jh., Obure, Ralph Ombati, Palkhi, Yusuf, Alkhayat, Ali, Ali, Ali Sayed, Malek, Amgad Nashaat Abdel, Abdelsayed, Emad Fahim, Zahra, Tarek, Ayoub, Larissa, Sleilati, Fadi, Aoun, Rany, Algatanesh, Nassib, Fieturi, Nura Ahmed, Ng, Jen Siang, Díaz, Andrés Vega, Duran, Erik Efrain Sosa, Guerrero, José Eaazim Flores, Jasso, Manuel Meza, Flores, Manuel SSalas, Felix, Marcos José Serrato, Angulo, Victor Manuel Pinto, Mejdane, Abdelhadi, Aitali, Abdelmounaim, Amal, Benzakour, Zentar, Aziz, Bensaad, Ahmed, Yacir, El Alami, Jawad, Fassi Fihri Mohamed, Rachid, Mohamed Ghassane, Maliki-Alaoui, Mohamed, Ouadii, Mouaqit, Mohammed, Ouazni, Thein, Nyan, Koirala, Dinesh Prasad, Hilling, Denise, Pouwels, Sjaak, Okunlola, Abiodun Idowu, Adejumo, Adeyinka, Akinmade, Akinola, Shittu, Asimiyu Adekunle, Oluyomi, Ayodele Samuel, Abiodun, Azeez Lateef, Lawal, Bashir, Odion, Clement, Popoola, Ademola, Jolayemi, Edward, Shomoye, El-Zaki, Wuraola, Funmilola Olanike, Eke, Grace, Abiyere, Henry, Oluwasuyi, Ige, George, Ihediwa, Njokanma, Iloba Gabriel, Aremu, Isiaka, Dare, Julius Kolajo, Abdur-Rahman, Lukman, Ahmad, Misbahu Haruna, Oludara, Mobolaji Adewale, Mohammad, Mohammad Aminu, Adeoluwa, Ojajuni, Situ, Oladele, Agbonrofo, Peter, Kewulere, Raji Taofiq, Aliyu, Yakubu, Adebowale, Yusuf, Galala, Ahmed, Rao, Satish, Waleed, Aasma, Inam, Aatif, Shaikh, Abdul Razaque, Qureshi, Ahmad Uzair, Muhammad, Aneeqah Din, Ahmed, Arooj, Kerawala, Asad Ali, Aslam, Mohammad, Mehr, Asma, Javed, Ayesha, Ahmad, Farooq, Majid, Haroon Javaid, Ahmed, Hassan, Daudi, Irfan, Akhtar, Khalid, Niaz, Khurram, Anwer, Mariyah, Amir, Mohammed, Hanif, Muhammad Amir, Asif, Muhammad, Raza, Muhammad Asif, Khokhar, Muhammad Imran, Jameel, Muhammad Khurram, Nasir, Muhammad, Shafique, Muhammad Salman, Ateeb, Mujammad, Nadeem, Munawar, Shah, Rahmat Ullah, Waqar, Shahzad Hussain, Shah, Shahzad Alam, Waseem, Talat, Ghafoor, Tariq, Fatima, Tauseef, Bashir, Umar, Gonzales, Erick Ivan Huaman, Ruiz, Luis Angel Garcia, Freitas, Carla, De Sousa, Xavier, Al-Bahrani, Ahmed, Portela, Carlos Antonio Sanchez, Elgazar, Elsayed Aly, Robles, Eloy Morasen, Khan, Irfan Jan, Jarboa, Lutfi, Khawar, Mahwish, Echevarria, Miguel Jose Pinto, Bashah, Moataz M., Dawdi, Salahaldeen, Musthafa, Shameel, Ali, Syed Muhammad, Ciubotaru, Cezar, Bonci, Eduard-Alexandru, Muresan, Mihai-Stefan, Bogdan, Stoica, Ioan, Tanase, Zubayraeva, Albina, Derinov, Aleksandr, Zakharenko, Alexander, Novikova, Anastasia, Bashlachev, Andrey, Kaldarov, Ayrat, Stanislav, Berelavichus, Gorin, David, Puzenko, Dmitriy, Kazachenko, Ekaterina, Ashimov, Erkin, Medkova, Iuliia, Ignatov, Ivan, Sergeevich, Kochetkov Viktor, Sidorova, Lyudmila, Kiselev, Michail, Danilov, Michail, Aleksandr, Ogoreltsev, Rodimov, Sergey, Garmanovs, Tatiana, Kitsenko, Yury, Valery, Nekoval, Japhet, Ntezamizero, Sibiany, Abdulrahman, Saadeldin, Abdelhalim, Abuosba, Abdelrahman, Alawadhi, Abdulbari Mohammed, Alharbi, Abdulhamid, Althumali, Abdullah, Alghuliga, Abdullah, Alotaibi, Abdullah, Abduraboh, Abdullah Fayez, Kateb, Abdullah, Sindy, Abdullah, Al Eisa, Abdulmohsen, Alotaibi, Abdulrahman, Almulhim, Abdulrhman, Aljawhari, Adel Ali, Abozeid, Ahmad Mahmoud, Saad, Ahmad, Alqarni, Ahmed, Alwan, Ahmed, Alwusaibie, Ahmed, Bafaraj, Ahmed, Eldeeb, Ahmed, Tarabay, Ahmed, Mohammed, Mahfoudh, Alhedaithy, Alhanouf, Almaghrabi, Alhassan Hesham, Abed, Ali Ibrahim Eldawy, Abdullah, Alqahtani Ali, Semilan, Anmar, Farag, Mohamed, Khudhayr, Essa, Hussain, Marwah, Abbas, Ghanem, Alqudaihi, Heba, Abualnaja, Yousra, Shaheen, Abelnasser, Mubarak, Ashraf Abdelazeem Mohamed, Ali, Bandar Idrees A., Alhazmi, Barrag, Hijazi, Bilal Ahmed, Abdulrahman, Chadi, Oyedepo, Charles Olajide, Alzamel, Heythem, Tairab, Elsanousi Ibrahim Sabir, Alsuwaimel, Munir A., Hejazi, Soha, Alnoqaidan, Emad, Alhussien, Fade Ahmed, Jallad, Fadi Sami, Khadwardi, Faisal, Alghamdi, Faisal Saleh, Haddad, Feras, Sauri, Fozan, Alafghani, Haitham, Alfalah, Haitham, Gad, Hamada, Aboelmagid, Hamdy Haggag Ebrahim, Ibrahim, Hamed, Elzayady, Hany M., Sharafeldin, Hatem Abdelrahman Ahmed, Sembawa, Hatem A., Alabbas, Haytham, Abbas, Hazem, Elgamal, Hesham, Alawfi, Homoud, Al-Sadery, Humood, Abdelmotaleb, Hussien Ali, Al Hassn, Ibrahim, Mudawi, Ishag M., Nekhala, Islam, Elsanhoury, Kareem, Said, Khalid Babieker, Albeshri, Khalid A., Albahooth, Khalid, Mohammed, Khalid Fathelrahman Bakier, Asar, Khalid Mohammad Ibrahim, Osman, Luqman, Alzamanan, Mahdi, Alnabarawi, Mahmoud, Althobaiti, Majid, Elsayed, Mohamed Abdelmoneim, Al Naeb, Mohamed, Hassan, Mohamed Salah Eldin, Abdelhamid, Mohamed Sayed, Alyami, Mohammad, Mirza, Mohammad Amin, Sayouh, Mohammad, Alkhayat, Mohammed Amer, Basendowah, Mohammed, Ghunaim, Mohammed, Alhussaini, Mohammed Khalid, Khoj, Mohammed, Sbaih, Mohammed, Saeed, Muhammad Ahmad, Ali, Muhammad Zulfiqar, Abdelaziz, Nabil Yassin Tammam, Malibary, Nadim, Abdo, Nael, Amer, Nasser Mohammed, Al Turki, Neamat Ahmed Ali, Durayb, Norah, Yassin, Nouf, Akeel, Nouf, Larbi, Noureddine, Alsallum, Ofays, Suliman, Omar AAbu, Elsherbiny, Osama, Abusalem, Osama, Albalawi, Ibrahim Altedlawi, Abutalib, Raid Abdullah, Alarabi, Rayan, Khan, Roaa Ghazi, Alazzam, Saleh, Alghamdi, Saleh, Alsawat, Salem, Salim, Sami, Alshukr, Sarah, Alzahrani, Saud, Golea, Smain, Alowairdhi, Tumadher, Salman, Usama, Abusiam, Wael, Abualkhair, Wael, Saber, Wael, Tashkandi, Wail, Alhazmi, Waleed, Tashkandi, Waleed, Yassine, Wassim Abou, Alshabi, Yaser Ahmad, Ibrahim, Yaser, Shahin, Yasser, Ibrahim, Yassin, Aljathlany, Yousef, Alnahas, Yousef, Alrashidi, Yousef, Wali, Zubair, Ndong, Abdourahmane, Ba, Mamadou, Faye, Papa Mamadou, Arbutina, Dragana, Milic, Ljiljana, Cuk, Vladica, Hussein, Abdinafic Mohamud, Mccaul, Jeannie, Bertels, Laurie, Pohl, Linda, Arnold, Marion, Mbatani, Nomonde, Oosthuizen, Pj, Rayamajhi, Shreya, Vosloo, Susan, Jooma, Uzair, Landaluce-Olavarria, Aitor, Vázquez-Melero, Alba, Marcos, Alberto, Puerto Puerto, Alejandro, De La Hermosa, Alicia Ruiz, Senent-Boza, Ana, Ugarte-Sierra, Bakarne, Montalbán, Beatriz Cros, Martin-Perez, Beatriz, Gomez, Caroina Gonzalez, Colás-Ruiz, Enrique, Santos, Esther Garcia, Senra, Fatima, Mora-Guzmán, Ismael, Dziakova, Jana, Díaz, Jeancarlos J. Trujillo, Silva, Jesús, Laina, Juan Luis Blas, Tallon-Aguilar, Luis, Di Martino, Marcello, Chacón, Mario Franco, Frasson, Matteo, Calvo, Mikel Prieto, Millan, Monica, Tejedoe, Patricia, Pérez-Bertólez, Sonia, Turrado-Rodríguez, Víctor, Elsanosi, Abdelrhman Azhari Mohammed, Abdalbakheet, Duaa, Ahmed, Mohamed, Salim, Omer El Faroug H., Youssef, Mohamed, Barbon, Carlotta, Bouchrika, Amal, Maghrebi, Houcine, Loukil, Issam, Yildiz, Alp, Dursun, Ayberk, Gulcu, Baris, Calik, Bulent, Eral, Burak, Yeşilyurt, Değercan, Yakar, Fatih, Akin, Furkan Atakan, Kilinc, Gizem, Uslu, Gülberk, Tuncer, Korhan, Koc, Mehmet Ali, Leventoğlu, Sezai, Sokmen, Selman, Atici, Semra Demirli, Kaya, Tayfun, Dere, Ümit Akın, Kırmızı, Yasemin, Ssenono, Kavuma Daniel, Lule, Herman, Mbiine, Ronald, Hamza, Ahmed, Ali, Shabeer, Peediyakkal, Saidalavi Padinhare, Varma, Gopala Pillay, Mussa, Haidar Aal, Al-Masari, Hayder Makki, Shehata, Mina, Seiam, Moham, Aziz, Muhammad Akram Abdul, Nimir, Nessrein, Khare, Ritu, Rashid, Shahid, Kazim, Shuiab, Gondal, Zafar, Sherif, Ahmed Elshawadfy, Ghanem, Ahmed, Helmy, Ahmed Hazem I., Ibrahim, Ahmed, Elshaer, Ahmed Mohammed, Marzouk, Ahmed Msm, Tamburrini, Alessandro Paolo, Parente, Alessandro, Light, Alexander, Diamantopoulou, Angela, Singh, Baljit, Gurung, Binay, Frauenfelder, Claire, Leo, Cosimo Alex, Raptis, Dimitri, Thakrar, Dixa, Madhuri, Thumuluru Kavitha, Tsounaki, Efthymia, Garreffa, Emanuele, Soggiu, Fiammetta, Stavrou, George, Ng, Hwei Jene, Tabasi, Hani, Nasef, Hazem, Kostakis, Ioannis D., Jeffery, James, Warusavitarne, Janindra, Lund, Jon, Qurashi, Kamran, Sahnan, Kapil, Tong, Kin Seng, Orecchia, Luca, Kaur, Mandeep, Zaidi, Mariam, Ganau, Mario, Hassan, Mohamed Ali Gad, Curtis, Nathan, Bhatt, Nikita, Machairas, Nikolaos, Zafar, Noman, Toma, Omar, Sarmah, Panchali, Bassuni, Majid, Davies, Justin, Shawer, Sami, Shawer, Sherif, Lewis, Sophia, Subramanian, Sivaraman, Ahmad, Suhaib, Nadeem, Uqba, Njau, Aidan, Tohamy, Aley Eldin, Pakula, Andrea M., Simioni, Andrea, Jarvis, Bennie L., Skandalakis, Georgios P., Hesham, Hosai Todd, Isaiah, Isaac A., Villwock, Jennifer, Martin, Linda W., Kress, Melissa, Sebelik, Merry, Lathan, Sanaz, Towfigh, Shirin, Holubar, Stefan D., Demeester, Steve, Alshehari, Mohammed Mohammed Hasan, Ghabisha, Saif Ali, Abdulatef, Shehab Ahmed Ali, Al-Kubati, Waheeb, Obadiel, Yasser Abdurabo, Gots, Alexander, Nakazwe, Mildred, Chipaila, Jackson, and Mazingi, Dennis

Abstract

BackgroundSARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice.MethodsThis is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure.ResultsNine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout.There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management.ResultsNine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout.There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits

Published
2024

32. Status of cosmic-ray antideuteron searches

Author

von Doetinchem, P., Aramaki, T., Boggs, S., Bufalino, S., Dal, L., Donato, F., Fornengo, N., Fuke, H., Grefe, M., Hailey, C., Hamilton, B., Ibarra, A., Mitchell, J., Mognet, I., Ong, R. A., Pereira, R., Perez, K., Putze, A., Raklev, A., Salati, P., Sasaki, M., Tarle, G., Urbano, A., Vittino, A., Wild, S., Xue, W., and Yoshimura, K.

Subjects
High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The precise measurement of cosmic-ray antiparticles serves as important means for identifying the nature of dark matter. Recent years showed that identifying the nature of dark matter with cosmic-ray positrons and higher energy antiprotons is difficult, and has lead to a significantly increased interest in cosmic-ray antideuteron searches. Antideuterons may also be generated in dark matter annihilations or decays, offering a potential breakthrough in unexplored phase space for dark matter. Low-energy antideuterons are an important approach because the flux from dark matter interactions exceeds the background flux by more than two orders of magnitude in the low-energy range for a wide variety of models. This review is based on the "dbar14 - dedicated cosmic-ray antideuteron workshop", which brought together theorists and experimentalists in the field to discuss the current status, perspectives, and challenges for cosmic-ray antideuteron searches and discusses the motivation for antideuteron searches, the theoretical and experimental uncertainties of antideuteron production and propagation in our Galaxy, as well as give an experimental cosmic-ray antideuteron search status update. This report is a condensed summary of the article "Review of the theoretical and experimental status of dark matter identification with cosmic-ray antideuteron" (arXiv:1505.07785)., Comment: 9 pages, 4 figures, ICRC 2015 proceedings

Published
2015

33. Review of the theoretical and experimental status of dark matter identification with cosmic-ray antideuterons

Author

Aramaki, T., Boggs, S., Bufalino, S., Dal, L., von Doetinchem, P., Donato, F., Fornengo, N., Fuke, H., Grefe, M., Hailey, C., Hamilton, B., Ibarra, A., Mitchell, J., Mognet, I., Ong, R. A., Pereira, R., Perez, K., Putze, A., Raklev, A., Salati, P., Sasaki, M., Tarle, G., Urbano, A., Vittino, A., Wild, S., Xue, W., and Yoshimura, K.

Subjects
High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

Recent years have seen increased theoretical and experimental effort towards the first-ever detection of cosmic-ray antideuterons, in particular as an indirect signature of dark matter annihilation or decay. In contrast to indirect dark matter searches using positrons, antiprotons, or gamma-rays, which suffer from relatively high and uncertain astrophysical backgrounds, searches with antideuterons benefit from very suppressed conventional backgrounds, offering a potential breakthrough in unexplored phase space for dark matter. This article is based on the first dedicated cosmic-ray antideuteron workshop, which was held at UCLA in June 2014. It reviews broad classes of dark matter candidates that result in detectable cosmic-ray antideuteron fluxes, as well as the status and prospects of current experimental searches. The coalescence model of antideuteron production and the influence of antideuteron measurements at particle colliders are discussed. This is followed by a review of the modeling of antideuteron propagation through the magnetic fields, plasma currents, and molecular material of our Galaxy, the solar system, the Earth's geomagnetic field, and the atmosphere. Finally, the three ongoing or planned experiments that are sensitive to cosmic-ray antideuterons, BESS, AMS-02, and GAPS, are detailed. As cosmic-ray antideuteron detection is a rare event search, multiple experiments with orthogonal techniques and backgrounds are essential. Many theoretical and experimental groups have contributed to these studies over the last decade, this review aims to provide the first coherent discussion of the relevant dark matter theories that antideuterons probe, the challenges to predictions and interpretations of antideuteron signals, and the experimental efforts toward cosmic antideuteron detection., Comment: 72 pages, 20 figures

Published
2015
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34. The Connection Between the Positron Fraction Anomaly and the Spectral Features in Galactic Cosmic-Ray Hadrons

Author

Tomassetti, N. and Donato, F.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

Recent data on Galactic cosmic-ray (CR) leptons and hadrons gave rise to two exciting problems: on the lepton side, the origin of the rise of the CR positron fraction e+/(e- + e+) at ~10 - 300 GeV of energy; on the hadron side, the nature of the spectral hardening observed in CR protons and nuclei at ~TeV energies. The lepton anomaly indicates the existence of a nearby e+/- source. It has been proposed that high-energy positrons can be produced inside nearby supernova remnants (SNRs) via interactions of CR hadrons with the ambient medium. A distinctive prediction of this mechanism is a high-energy rise of the boron-to-carbon ratio, which has not been observed. It also requires old SNRs at work (with ineffective magnetic field amplification and slow shock speed), that cannot account for the CR hadronic spectra observed up to the knee energies (~5 PeV). We propose a new picture where, in addition to such a nearby CR accelerator, the high-energy spectrum of CR hadrons is provided by the large-scale population of SNRs, on average younger, that can efficiently accelerate CRs up to the knee. Under this scenario, the spectral hardening of CR hadrons can be naturally interpreted as the transition between the two components. As we will show, our two-component model breaks the connection between the positron fraction and the boron-to-carbon ratio, which is now predicted to decrease with energy in accordance with the data. Forthcoming data from AMS will be crucial for testing this model., Comment: 5 pages, 3 figures; matches the published version

Published
2015
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36. Management and Treatment of External Hemorrhoidal Thrombosis

Author

Arcangelo Picciariello, Marcella Rinaldi, Ugo Grossi, Luigi Verre, Michele De Fazio, Agnese Dezi, Giovanni Tomasicchio, Donato F Altomare, and Gaetano Gallo

Subjects
hemorrhoidal disease, external hemorrhoidal thrombosis, hemorrhoidectomy, surgery, pregnancy, Surgery, RD1-811
Abstract

BackgroundExternal hemorrhoidal thrombosis (EHT) is a common complication of hemorrhoidal disease. This condition causes extreme pain, likely resulting from internal anal sphincter hypertonicity, which traps the hemorrhoids below the dentate line thus leading to congestion and swelling. The choice of treatment remains controversial and both conservative and surgical options have been proposed in the last decades.MethodsThis mini-review focuses on the most relevant studies found in literature evaluating conservative and surgical management of EHT. Special conditions such as pregnancy and EHT in elderly patients have been considered.ResultsTraditionally, symptoms duration represents the discriminant in the choice between medical and surgical treatment. Several Coloproctological Societies considered conservative treatment as the first-line approach to EHT and a variety of options have been proposed: wait and see, mixture of flavonoids, mix of lidocaine and nifedipine, botulinum toxin injection and topical application of 0.2% glyceryl trinitrate. Meanwhile, different surgical treatments are recommended when EHT fails to respond to conservative management or when symptoms onset falls within the last 48–72 h: drainage with radial incision, conventional excision, excision under local anesthesia and stapled technique.ConclusionThe management and treatment of EHT is still controversial since no specific guidelines have been published. Both medical and surgical treatment have been proven effective but randomized clinical trials and structured consensus-based guidelines are warranted.

Published
2022
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38. Diffuse gamma-ray emission from galactic pulsars

Author

Calore, F., Di Mauro, M., and Donato, F.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Millisecond Pulsars are second most abundant source population discovered by the Fermi-LAT. They might contribute non-negligibly to the diffuse emission measured at high latitudes by Fermi-LAT, the IDGRB. Gamma-ray sources also contribute to the anisotropy of the IDGRB measured on small scales by Fermi-LAT. We aim to assess the contribution of the unresolved counterpart of the detected MSPs population to the IDGRB and the maximal fraction of the measured anisotropy produced by this source class. We model the MSPs spatial distribution in the Galaxy and the gamma-ray emission parameters by considering radio and gamma-ray observational constraints. By simulating a large number of MSPs populations, we compute the average diffuse emission and the anisotropy 1-sigma upper limit. The emission from unresolved MSPs at 2 GeV, where the peak of the spectrum is located, is at most 0.9% of the measured IDGRB above 10 degrees in latitude. The 1-sigma upper limit on the angular power for unresolved MSP sources turns out to be about a factor of 60 smaller than Fermi-LAT measurements above 30 degrees. Our results indicate that this galactic source class represents a negligible contributor to the high-latitude gamma-ray sky and confirm that most of the intensity and geometrical properties of the measured diffuse emission are imputable to other extragalactic source classes. Nevertheless, given the MSP distribution, we expect them to contribute significantly to the gamma-ray diffuse emission at low latitudes. Since, along the galactic disk, the population of young Pulsars overcomes in number the one of MSPs, we compute the gamma-ray emission from the whole population of unresolved Pulsars in two low-latitude regions: the inner Galaxy and the galactic center., Comment: 19 pages, 26 figures. It matches the published version, minor changes only

Published
2014
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39. Gamma-ray anisotropies from dark matter in the Milky Way: the role of the radial distribution

Author

Calore, F., De Romeri, V., Di Mauro, M., Donato, F., Herpich, J., Maccio', A. V., and Maccione, L.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, High Energy Physics - Phenomenology
Abstract

The annihilation of dark matter particles in the halo of galaxies may end up into gamma rays, which travel almost unperturbed till to their detection at Earth. This annihilation signal can exhibit an anisotropic behavior quantified by the angular power spectrum, whose properties strongly depend on the dark matter distribution and its clumpiness. We use high resolution pure dark matter N-body simulations to quantify the contribution of different components (main halo and satellites) to the global signal as a function of the analytical profile adopted to describe the numerical results. We find that the smooth main halo dominates the angular power spectrum of the gamma-ray signal up to quite large multipoles, where the sub-haloes anisotropy signal starts to emerge, but the transition multipole strongly depends on the assumed radial profile. The extrapolation down to radii not resolved by current numerical simulations can affect both the normalization and the shape of the gamma-ray angular power spectrum. For the sub-haloes described by an asymptotically cored dark matter distribution, the angular power spectrum shows an overall smaller normalization and a flattening at high multipoles. Our results show the criticality of the dark matter density profile shape in gamma-ray anisotropy searches, and evaluate quantitatively the intrinsic errors occurring when extrapolating the dark matter radial profiles down to spatial scales not yet explored by numerical simulations., Comment: 7 pages, 8 figures. It matches the version published in MNRAS

Published
2014
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40. Interpretation of AMS-02 electrons and positrons data

Author

Di Mauro, M., Donato, F., Fornengo, N., Lineros, R., and Vittino, A.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, High Energy Physics - Phenomenology
Abstract

We perform a combined analysis of the recent AMS-02 data on electrons, positrons, electrons plus positrons and positron fraction, in a self-consistent framework where we realize a theoretical modeling of all the astrophysical components that can contribute to the observed fluxes in the whole energy range. The primary electron contribution is modeled through the sum of an average flux from distant sources and the fluxes from the local supernova remnants in the Green catalog. The secondary electron and positron fluxes originate from interactions on the interstellar medium of primary cosmic rays, for which we derive a novel determination by using AMS-02 proton and helium data. Primary positrons and electrons from pulsar wind nebulae in the ATNF catalog are included and studied in terms of their most significant (while loosely known) properties and under different assumptions (average contribution from the whole catalog, single dominant pulsar, a few dominant pulsars). We obtain a remarkable agreement between our various modeling and the AMS-02 data for all types of analysis, demonstrating that the whole AMS-02 leptonic data admit a self-consistent interpretation in terms of astrophysical contributions., Comment: 33 pages, 26 figures and 4 tables, v2: accepted for publication in JCAP, minor changes relative to v1

Published
2014
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42. Health promotion in universities: the national university smoke-free network

Author

Campo, L, Riva, M, Barbic, F, Donato, F, Moriondo, A, Villani, S, Cristini, A, Cattaruzza, M, Corradi, M, Merusi, F, Paoli, A, Monaco, M, Chiarantini, L, Barbieri, E, Santarelli, L, Paoloni, L, Florena, A, Fustinoni, S, Campo L., Riva M., Barbic F., Donato F., Moriondo A., Villani S., Cristini A. L., Cattaruzza M. S., Corradi M., Merusi F., Paoli A., Monaco M. P., Chiarantini L., Barbieri E., Santarelli L., Paoloni L., Florena A. M., Fustinoni S., Campo, L, Riva, M, Barbic, F, Donato, F, Moriondo, A, Villani, S, Cristini, A, Cattaruzza, M, Corradi, M, Merusi, F, Paoli, A, Monaco, M, Chiarantini, L, Barbieri, E, Santarelli, L, Paoloni, L, Florena, A, Fustinoni, S, Campo L., Riva M., Barbic F., Donato F., Moriondo A., Villani S., Cristini A. L., Cattaruzza M. S., Corradi M., Merusi F., Paoli A., Monaco M. P., Chiarantini L., Barbieri E., Santarelli L., Paoloni L., Florena A. M., and Fustinoni S.

Abstract

Introduction With the aim of implementing common policies of health promotion to counter the use of tobacco cigarettes and new products and e-cig at university, the UNIVERSITY SMOKE-FREE network was set up in Italy. Objective The main objectives of the network are: to update and uniform the university regulations; to investigate exposure of students and staff to active and passive smoking by means of a multicentre survey; to implement initiatives for helping students to stop smoking; to produce information and teaching materials. Material and Methods With the involvement of the university governments, a network was set up comprising 14 universities: Milan La Statale (UNIMI), Milan-Bicocca, Milan-Humanitas, Brescia, Insubria, Pavia, Bergamo, Rome Sapienza, Parma, Padua, Florence, Urbino, the Polytechnic University of Marche, and Palermo. In order to carry out the survey, a questionnaire was developed and validated1, investigating active cigarette smoking, use of new products, exposure to passive smoking, knowledge of the health effects of smoking, and knowledge of, and agreement on regulations. Results All network universities have started to review and update their smoke-free regulations. The survey protocol, developed at UNIMI, was shared among the universities for approval by their respective Ethics Committees. The survey was completed in 2021 by the University of Milan La Statale, and in May-July 2023 by the Universities of Brescia and Urbino, while it will be conducted in the other universities in 2024. To date, more than 10000 students participated in the survey (11-25% of students). First results show differences among universities and scientific and humanistic faculties, in terms of active and passive smoking, and awareness of risks of smoking2. Conclusions The establishment of the UNIVERSITY SMOKE-FREE network is an important step to counter smoking at university. Conducting a multicentre survey may be useful to develop information material and implement com

Published
2023

43. Promozione della salute in università: la rete nazionale università smoke-free

Author

Campo, L, Riva, M, Barbic, F, Donato, F, Moriondo, A, Villani, S, Cristini, A, Cattaruzza, M, Corradi, M, Merusi, F, Paoli, A, Monaco, M, Chiarantini, L, Barbieri, E, Santarelli, L, Paoloni, L, Florena, A, Fustinoni, S, Campo L, Riva M, Barbic F, Donato F, Moriondo A, Villani S, Cristini AL, Cattaruzza MS, Corradi M, Merusi F, Paoli A, Monaco MP, Chiarantini L, Barbieri E, Santarelli L, Paoloni L, Florena AM, Fustinoni S., Campo, L, Riva, M, Barbic, F, Donato, F, Moriondo, A, Villani, S, Cristini, A, Cattaruzza, M, Corradi, M, Merusi, F, Paoli, A, Monaco, M, Chiarantini, L, Barbieri, E, Santarelli, L, Paoloni, L, Florena, A, Fustinoni, S, Campo L, Riva M, Barbic F, Donato F, Moriondo A, Villani S, Cristini AL, Cattaruzza MS, Corradi M, Merusi F, Paoli A, Monaco MP, Chiarantini L, Barbieri E, Santarelli L, Paoloni L, Florena AM, and Fustinoni S.

Published
2023

44. Diffuse $\gamma$-ray emission from unresolved BL Lac objects

Author

Di Mauro, M., Donato, F., Lamanna, G., Sanchez, D. A., and Serpico, P. D.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Blazars represent the most abundant class of high-energy extragalactic $\gamma$-ray sources. The subset of blazars known as BL Lac objects is on average closer to Earth and characterized by harder spectra at high energy than the whole sample. The fraction of BL Lacs that is too dim to be detected and resolved by current $\gamma$-ray telescopes is therefore expected to contribute to the high-energy isotropic diffuse $\gamma$-ray background (IGRB). The IGRB has been recently measured over a wide energy range by the Large Area Telescope (LAT) on board the Gamma-ray Space Telescope ({\it Fermi}). We present a new prediction of the diffuse $\gamma$-ray flux due to the unresolved BL Lac blazar population. The model is built upon the spectral energy distribution and the luminosity function derived from the fraction of BL Lacs detected (and spectrally characterized) in the $\gamma$-ray energy range. We focus our attention on the ${\cal O}(100)$ GeV energy range, predicting the emission up to the TeV scale and taking into account the absorption on the extragalactic background light. In order to better shape the BL Lac spectral energy distribution, we combine the {\it Fermi}-LAT data with Imaging Atmospheric Cerenkov Telescopes measurements of the most energetic sources. Our analysis is carried on separately for low- and intermediate-synchrotron-peaked BL Lacs on one hand, and high-synchrotron-peaked BL Lacs on the other one: we find in fact statistically different features for the two. The diffuse emission from the sum of both BL Lac classes increases from about 10$\%$ of the measured IGRB at 100 MeV to $\sim$100$\%$ of the data level at 100 GeV. At energies greater than 100 GeV, our predictions naturally explain the IGRB data, accommodating their softening with increasing energy. Uncertainties are estimated to be within of a factor of two of the best-fit flux up to 500 GeV., Comment: 14 pages, 6 figures. Version 4: Minor typos corrections, notably minus sign in the exponent of the square brackets of Eq.s A2, A6 and luminosity units in Table 2

Published
2013
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45. Diffuse $\gamma$-ray emission from misaligned active galactic nuclei

Author

Di Mauro, M., Donato, F., and Calore, F.

Subjects
Astrophysics - Cosmology and Extragalactic Astrophysics, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

We calculate the diffuse $\gamma$-ray emission due to the population of misaligned AGN (MAGN) unresolved by the Large Area Telescope (LAT) on the {\it Fermi} Gamma-ray Space Telescope ({\it Fermi}). A correlation between the $\gamma$-ray luminosity and the radio-core luminosity is established and demonstrated to be physical by statistical tests, as well as compatible with upper limits based on {\it Fermi}-LAT data for a large sample of radio-loud MAGN. We constrain the derived $\gamma$-ray luminosity function by means of the source count distribution of the MAGN detected by the {\it Fermi}-LAT. We finally estimate the diffuse $\gamma$-ray flux due to the whole MAGN population which ranges from 10% up to nearly the entire measured Isotropic Gamma-Ray Background (IGRB). We evaluate also the room left to galactic DM at high latitudes ($>10^\circ$), by taking into account the results on the MAGN together with the other significant galactic and extragalactic $\gamma$-rays emitting sources., Comment: Proceedings of Rencontres de Moriond, La Thuile, March 9th - 16th, 2013

Published
2013

46. A fixed-target programme at the LHC for heavy-ion, hadron, spin and astroparticle physics: AFTER@LHC

Author

Kikoła, D., Brodsky, S.J., Cavoto, G., Da Silva, C., Donato, F., Echevarria, M.G., Ferreiro, E.G., Hadjidakis, C., Hřivnáčová, I., Klein, A., Kurepin, A., Kusina, A., Lansberg, J.P., Lorcé, C., Lyonnet, F., Makdisi, Y., Massacrier, L., Porteboeuf, S., Quintans, C., Rakotozafindrabe, A., Robbe, P., Scandale, W., Schienbein, I., Seixas, J., Shao, H.S., Signori, A., Topilskaya, N., Trzeciak, B., Uras, A., Wagner, J., Yamanaka, N., Yang, Z., and Zelenski, A.

Published
2019
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47. Secondary Cosmic Ray Nuclei from Supernova Remnants and Constraints to the Propagation Parameters

Author

Tomassetti, N. and Donato, F.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The secondary-to-primary B/C ratio is widely used to study the cosmic ray (CR) propagation processes in the Galaxy. It is usually assumed that secondary nuclei such as Li-Be-B are entirely generated by collisions of heavier CR nuclei with the interstellar medium (ISM). We study the CR propagation under a scenario where secondary nuclei can also be produced or accelerated from galactic sources. We consider the processes of hadronic interactions inside supernova remnants (SNRs) and re-acceleration of background CRs in strong shocks. Thus, we investigate their impact in the propagation parameter determination within present and future data. The spectra of Li-Be-B nuclei emitted from SNRs are harder than those due to CR collisions with the ISM. The secondary-to-primary ratios flatten significantly at ~TeV/n energies, both from spallation and re-acceleration in the sources. The two mechanisms are complementary to each other and depend on the properties of the local ISM around the expanding remnants. The secondary production in SNRs is significant for dense background media, n ~1 cm^-3, while the amount of re-accelerated CRs is relevant for SNRs expanding into rarefied media, n ~0.1 cm-3. Due to these effects, the the diffusion parameter 'delta' may be misunderstood by a factor of ~5-15%. Our estimations indicate that an experiment of the AMS-02 caliber can constrain the key propagation parameters while breaking the source-transport degeneracy, for a wide class of B/C-consistent models. Given the precision of the data expected from on-going experiments, the SNR production/acceleration of secondary nuclei should be considered, if any, to prevent a possible mis-determination of the CR transport parameters., Comment: 13 pages, 9 figures; matches the published version

Published
2012
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48. Les Houches 2011: Physics at TeV Colliders New Physics Working Group Report

Author

Brooijmans, G., Gripaios, B., Moortgat, F., Santiago, J., Skands, P., Vásquez, D. Albornoz, Allanach, B. C., Alloul, A., Arbey, A., Azatov, A., Baer, H., Balázs, C., Barr, A., Basso, L., Battaglia, M., Bechtle, P., Bélanger, G., Belyaev, A., Benslama, K., Bergström, L., Bharucha, A., Boehm, C., Bondarenko, M., Bondu, O., Boos, E., Boudjema, F., Bringmann, T., Brown, M., Bunichev, V., Calvet, S., Campanelli, M., Carmona, A., Cerdeño, D. G., Chala, M., Chivukula, R. S., Chowdhury, D., Christensen, N. D., Cirelli, M., Cox, S., Cranmer, K., Da Silva, J., Delahaye, T., De Roeck, A., Djouadi, A., Dobson, E., Dolan, M., Donato, F., La Rochelle, G. Drieu, Duda, G., Duhr, C., Dumont, B., Edsjö, J., Ellis, J., Evoli, C., Falkowski, A., Felcini, M., Fuks, B., Gabrielli, E., Gaggero, D., Gascon-Shotkin, S., Ghosh, D. K., Giammanco, A., Godbole, R. M., Gondolo, P., Goto, T., Grasso, D., Gris, P., Guadagnoli, D., Gunion, J. F., Haisch, U., Hartgring, L., Heinemeyer, S., Hirsch, M., Hewett, J., Ismail, A., Jeltema, T., Kadastik, M., Kakizaki, M., Kannike, K., Khalil, S., Kneur, J-L., Krämer, M., Kraml, S., Kreiss, S., Lavalle, J., Leane, R., Lykken, J., Maccione, L., Mahmoudi, F., Mangano, M., Martin, S. P., Maurin, D., Moreau, G., Moretti, S., Moskalenko, I., Moultaka, G., Muhlleitner, M., Niessen, I., O'Leary, B., Orlando, E., Panci, P., Polesello, G., Porod, W., Porter, T., Profumo, S., Prosper, H., Pukhov, A., Racioppi, A., Raidal, M., de Traubenberg, M. Rausch, Renaud, A., Reuter, J., Rizzo, T. G., Robens, T., Rodríguez-Marrero, A. Y., Salati, P., Savage, C., Scott, P., Sekmen, S., Semenov, A., Shan, C. -L., Shepherd-Themistocleous, C., Simmons, E. H., Slavich, P., Speckner, C., Staub, F., Strong, A., Taillet, R., Thomas, F. S., Thomas, M. C., Tomalin, I., Tytgat, M., Ughetto, M., Valéry, L., Walker, D. G. E., Weiler, A., West, S. M., White, C. D., Williams, A. J., Wingerter, A., Wymant, C., Yu, J. -H., Yuan, C. -P., and Zerwas, D.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

We present the activities of the "New Physics" working group for the "Physics at TeV Colliders" workshop (Les Houches, France, 30 May-17 June, 2011). Our report includes new agreements on formats for interfaces between computational tools, new tool developments, important signatures for searches at the LHC, recommendations for presentation of LHC search results, as well as additional phenomenological studies., Comment: 243 pages, report of the Les Houches 2011 New Physics Group; fix three figures

Published
2012

49. Conservative upper limits on WIMP annihilation cross section from Fermi-LAT $\gamma$-rays

Author

Donato, F., Calore, F., and De Romeri, V.

Subjects
High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The spectrum of an isotropic extragalactic $\gamma$-ray background (EGB) has been measured by the Fermi-LAT telescope at high latitudes. Two new models for the EGB are derived from the subtraction of unresolved point sources and extragalactic diffuse processes, which could explain from 30% to 70% of the Fermi-LAT EGB. Within the hypothesis that the two residual EGBs are entirely due to the annihilation of dark matter (DM) particles in the Galactic halo, we obtain $conservative$ upper limits on their annihilation cross section \sigmav. Severe bounds on a possible Sommerfeld enhancement of the annihilation cross section are set as well. Finally, would {\sigmav} be inversely proportional to the WIMP velocity, very severe limits are derived for the velocity-independent part of the annihilation cross section., Comment: Proceedings of XII Taup Conference, Munich, September 2011

Published
2011
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50. p, He, and C to Fe cosmic-ray primary fluxes in diffusion models: Source and transport signatures on fluxes and ratios

Author

Putze, A., Maurin, D., and Donato, F.

Subjects
Astrophysics - Galaxy Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The propagated fluxes of proton, helium, and heavier primary cosmic-ray species (up to Fe) are a means to indirectly access the source spectrum of cosmic rays. We check the compatibility of the primary fluxes with the transport parameters derived from the B/C analysis, but also if they bring further constraints. Proton data are well described in the simplest model defined by a power-law source spectrum and plain diffusion. They can also be accommodated by models with, e.g., convection and/or reacceleration. There is no need for breaks in the source spectral indices below $\sim 1$ TeV/n. Fits on the primary fluxes alone do not provide physical constraints on the transport parameters. If we let free the source spectrum $dQ/dE = q \beta^{\eta_S} {\cal R}^{-\alpha}$ and fix the diffusion coefficient $K(R)= K_0\beta^{\eta_T} {\cal R}^{\delta}$ such as to reproduce the B/C ratio, the MCMC analysis constrains the source spectral index $\alpha$ to be in the range $2.2-2.5$ for all primary species up to Fe, regardless of the value of the diffusion slope $\delta$. The $\eta_S$ low-energy shape of the source spectrum is degenerate with the low-energy shape $\eta_T$ of the diffusion coefficient: we find $\eta_S-\eta_T\approx 0$ for p and He data, but $\eta_S-\eta_T\approx 1$ for C to Fe primary species. This is consistent with the toy-model calculation in which the shape of the p/He and C/O to Fe/O data is reproduced if $\eta_S-\eta_T\approx 0-1$ (no need for different slopes $\alpha$). When plotted as a function of the kinetic energy per nucleon, the low-energy p/He ratio is shaped mostly by the modulation effect, whereas primary/O ratios are mostly shaped by their destruction rate., Comment: 18 pages, 14 figures: accepted in A&A (1 table added)

Published
2010
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