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2. Vaccination against SARS-CoV-2 in pregnancy during the Omicron wave: the prospective cohort study of the Italian obstetric surveillance system

Author

Alberi, Irene, Camandona, Franco, Casucci, Paola, Cetin, Irene, Ciavattini, Andrea, Damiani, Fabrizio, Di Sebastiano, Francesca, Driul, Lorenza, Droghini, Fiorenza, Ettore, Giuseppe, Farsetti, Daniele, Franchi, Massimo Piergiuseppe, Leo, Livio, Liberati, Marco, Sacchi, Lucia Li, Locci, Mariavittoria, Martini, Claudio, Maso, Gianpaolo, Mecacci, Federico, Meloni, Alessandra, Mignuoli, Anna Domenica, Mondo, Luisa, Morano, Danila, Paradiso, Rocco, Perrone, Enrica, Piccinno, Roberta, Prefumo, Federico, Ramenghi, Luca, Rocca, Morena, Sampaolo, Letizia, Scalchi, Sabrina, Antonio Schettini, Sergio Crescenzo, Simeone, Daniela, Simeone, Serena, Steinkasserer, Martin, Taddei, Fabrizio, Tesorone, Marina, Trojano, Vito, Tronci, Caterina, Veneziano, Micaela, Vimercati, Antonella, Corsi Decenti, Edoardo, Salvatore, Michele Antonio, Mandolini, Donatella, and Donati, Serena

Published
2023
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3. A large series of molecular and serological specimens to evaluate mother-to-child SARS-CoV-2 transmission: a prospective study from the Italian Obstetric Surveillance System

Author

Alberi, Irene, Anelli, Gaia Maria, Baltaro, Federica, Bisulli, Maria, Brusa, Stefano, Cataneo, Ilaria, Cetin, Irene, Cuomo, Marianna, Rì, Pietro Dal, Cerbo, Lidia Di, Ferretti, Alice, Gismondo, Maria Rita, Grisolia, Gianpaolo, Livio, Stefania, Locci, Mariavittoria, Malentacchi, Francesca, Mecacci, Federico, Paccaloni, Barbara, Pedna, Maria Federica, Perrone, Enrica, Pignatti, Lucrezia, Piras, Martina, Primavera, Alessandra, Savasi, Valeria, Simeone, Serena, Taddei, Fabrizio, Tironi, Roberta, Torri, Arianna, Corsi Decenti, Edoardo, Salvatore, Michele Antonio, Mancon, Alessandro, Portella, Giuseppe, Rocca, Arianna, Vocale, Caterina, and Donati, Serena

Published
2023
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5. Availability of facility resources and services and infection-related maternal outcomes in the WHO Global Maternal Sepsis Study: a cross-sectional study

Author

Brizuela, Vanessa, Cuesta, Cristina, Bartolelli, Gino, Abdosh, Abdulfetah Abdulkadir, Abou Malham, Sabina, Assarag, Bouchra, Castro, Rigoberto, Díaz, Virginia, El Kak, Faysal, Elsheikh, Mohamed, Pérez, Aquilino M., Souza, João Paulo, Bonet, Mercedes, Abalos, Edgardo, Aman, Mohammad Iqbal, Noormal, Bashir, Espinoza, Marisa, Pasquale, Julia, Leroy, Charlotte, Roelens, Kristien, Vandenberghe, Griet, Agossou, M. Christian Urlyss, Goufodji Keke, Sourou, Tshabu Aguemon, Christiane, Apaza Peralta, Patricia Soledad, Conde Altamirano, Víctor, Hernández Muñoz, Rosalinda, Cecatti, José Guilherme, Ribeiro do Valle, Carolina, Batiene, Vincent, Cisse, Kadari, Ouedraogo, Henri Gautier, Cheang, Kannitha, Lam, Phirun, Rathavy, Tung, Simo, Elie, Tebeu, Pierre-Marie, Yakana, Emah Irene, Carvajal, Javier, Escobar, María Fernanda, Fernández, Paula, Colmorn, Lotte Berdiin, Langhoff-Roos, Jens, Mereci, Wilson, Vélez, Paola, Salah Eldin, Yasser, Sultan, Alaa, Teklu, Alula M., Worku, Dawit, Adanu, Richard, Govule, Philip, Noora Lwanga, Charles, Arriaga Romero, William Enrique, Flores Aceituno, María Guadalupe, Bustillo, Carolina, Lara, Bredy, Kumar, Vijay, Suri, Vanita, Trikha, Sonia, Cetin, Irene, Donati, Serena, Personeni, Carlo, Baimussanova, Guldana, Kabylova, Saule, Sagyndykova, Balgyn, Gwako, George, Osoti, Alfred, Qureshi, Zahida, Asylbasheva, Raisa, Boobekova, Aigul, Seksenbaeva, Damira, Itani, Saad Eddine, Minkauskienė, Meilė, Ramašauskaitė, Diana, Chikhwaza, Owen, Gadama, Luis, Malunga, Eddie, Dembele, Haoua, Sangho, Hamadoun, Zerbo, Fanta Eliane, Dávila Serapio, Filiberto, Herrera Maldonado, Nazarea, Islas Castañeda, Juan I., Cauaus, Tatiana, Curteanu, Ala, Petrov, Victor, Buyanjargal, Yadamsuren, Khishgee, Seded, Lkhagvasuren, Bat-Erdene, Essolbi, Amina, Moulki, Rachid, Jaze, Zara, Mariano, Arlete, Bique Osman, Nafissa, Einda, Hla Mya Thway, Maung, Thae Maung, Tin, Khaing Nwe, Gurung, Tara, Shrestha, Amir Babu, Shrestha, Sangeeta, Bloemenkamp, Kitty, Rijken, Marcus J., Van Den Akker, Thomas, Estrada, María Esther, Pavón Gómez, Néstor J., Adesina, Olubukola, Aimakhu, Chris, Fawole, Bukola, Chaudhri, Rizwana, Hamid, Saima, Khan, M. Adnan, Huatuco Hernández, María del Pilar, Zavaleta Pimentel, Nelly M., Andal, Maria Lu, Recidoro, Zenaida Dy, Martin, Carolina Paula, Budianu, Mihaela, Puşcaşiu, Lucian, Diouf, Léopold, Guirassy, Dembo, Moreira, Philippe Marc, Borovsky, Miroslav, Kovac, Ladislav, Kristufkova, Alexandra, Cebekhulu, Sylvia, Cornelissen, Laura, Soma-Pillay, Priya, Cararach, Vicenç, López, Marta, Vidal Benedé, María José, Jayakody, Hemali, Jayaratne, Kapila, Rowel, Dhammica, Nabag, Wisal, Omer, Sara, Tsoy, Victoria, Uzakova, Urunbish, Yunusova, Dilrabo, Siriwachirachai, Thitiporn, Tangsiriwatthana, Thumwadee, Dunlop, Catherine, Knight, Marian, Lissauer, David, Roman, Jhon, Vitureira, Gerardo, Tuan, Dinh Anh, Truong, Luong Ngoc, Hanh, Nghiem Thi Xuan, Madziyire, Mugove, Magwali, Thulani, Munjanja, Stephen, Baguiya, Adama, Chamillard, Mónica, Kouanda, Seni, Lumbiganon, Pisake, Nabhan, Ashraf, Nadisauskiene, Ruta, Bartlett, Linda, Bellissimo-Rodrigues, Fernando, Jacob, Shevin T., Shakoor, Sadia, Yunis, Khalid, Campodónico, Liana, Gamerro, Hugo, Giordano, Daniel, Althabe, Fernando, Gülmezoglu, A. Metin, Castro Banegas, Rigoberto, El-Kak, Faysal, El Sheikh, Mohamed, and Pérez, Aquilino M

Published
2021
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7. Trends in caesarean section rates in Europe from 2015 to 2019 using Robson's Ten Group Classification System: A Euro‐Peristat study

Author

Amyx, Melissa, Philibert, Marianne, Farr, Alex, Donati, Serena, Smárason, Alexander Kr, Tica, Vlad, Velebil, Petr, Alexander, Sophie, Durox, Mélanie, Elorriaga, Maria Fernandez, Heller, Günther, Kyprianou, Theopisti, Mierzejewska, Ewa, Verdenik, Ivan, Zīle‐Velika, Irisa, Zeitlin, Jennifer, Amyx, Melissa, Philibert, Marianne, Farr, Alex, Donati, Serena, Smárason, Alexander Kr, Tica, Vlad, Velebil, Petr, Alexander, Sophie, Durox, Mélanie, Elorriaga, Maria Fernandez, Heller, Günther, Kyprianou, Theopisti, Mierzejewska, Ewa, Verdenik, Ivan, Zīle‐Velika, Irisa, and Zeitlin, Jennifer

Abstract

Objective To assess changes in caesarean section (CS) rates in Europe from 2015 to 2019 and utilise the Robson Ten Group Classification System (TGCS) to evaluate the contribution of different obstetric populations to overall CS rates and trends. Design Observational study utilising routine birth registry data. Setting A total of 28 European countries. Population Births at ≥22 weeks of gestation in 2015 and 2019. Methods Using a federated model, individual‐level data from routine sources in each country were formatted to a common data model and transformed into anonymised, aggregated data. Main Outcome Measures By country: overall CS rate. For TGCS groups (by country): CS rate, relative size, relative and absolute contribution to overall CS rate. Results Among the 28 European countries, both the CS rates (2015, 16.0%–55.9%; 2019, 16.0%–52.2%) and the trends varied (from −3.7% to +4.7%, with decreased rates in nine countries, maintained rates in seven countries (≤ ± 0.2) and with increasing rates in 12 countries). Using the TGCS (for 17 countries), in most countries labour induction increased (groups 2a and 4a), whereas multiple pregnancies (group 8) decreased. In countries with decreasing overall CS rates, CS tended to decrease across all TGCS groups, whereas in countries with increasing rates, CS tended to increase in most groups. In countries with the greatest increase in CS rates (>1%), the absolute contributions of groups 1 (nulliparous term cephalic singletons, spontaneous labour), 2a and 4a (induction of labour), 2b and 4b (prelabour CS) and 10 (preterm cephalic singletons) to the overall CS rate tended to increase. Conclusions The TGCS shows varying CS trends and rates among countries of Europe. Comparisons between European countries, particularly those with differing trends, could provide insight into strategies to reduce CS without clinical indication., info:eu-repo/semantics/published

Published
2024

8. Frequency and management of maternal infection in health facilities in 52 countries (GLOSS): a 1-week inception cohort study

Author

Bonet, Mercedes, Brizuela, Vanessa, Abalos, Edgardo, Cuesta, Cristina, Baguiya, Adama, Chamillard, Mónica, Fawole, Bukola, Knight, Marian, Kouanda, Seni, Lumbiganon, Pisake, Nabhan, Ashraf, Nadisauskiene, Ruta J, Abdulkadir, Abdulfetah, Adanu, Richard MK, Aman, Mohammad Iqbal, Arriaga Romero, William E., Assarag, Bouchra, Bloemenkamp, Kitty W.M., Boobekova, Aigul, Budianu, Mihaela A., Cararach, Vicenç, Castro, Rigoberto, Cebekhulu, Sylvia, Cecatti, José Guilherme, Colmorn, Lotte Berdiin, Curteanu, Ala, Donati, Serena, Einda, Hla Mya Thway, El Deen, Yasser Salah, El Kak, Faysal, Elsheikh, Mohamed, Escobar-Vidarte, Maria F, Espinoza, Marisa Mabel, Estrada, María Ester, Gadama, Luis Aaron, Goufodji, Sourou B, Hamid, Saima, Hernandez Munoz, Rosalinda, Herrera Maldonado, Nazarea, Jayaratne, Kapila, Kabylova, Saule, Kristufkova, Alexandra, Kumar, Vijay, Lissauer, David, Mereci, Wilson, Minkauskiene, Meile, Moreira, Philippe, Munjanja, Stephen, B. Osman, Nafissa, Ouedraogo, Henri Gautier, Perez, Aquilino M., Pasquale, Julia, Puscasiu, Lucian, Qureshi, Zahida, Recidoro, Zenaida, C. Ribeiro-do-Valle, Carolina, Rowel, Dhammica, Sangho, Hamadoun, Shrestha, Amir Babu, Siriwachirachai, Thitiporn, Tebeu, Pierre Marie, Tin, Khaing Nwe, Tuan, Dinh Anh, Tung, Rathavy, Vandenberghe, Griet, Yadamsuren, Buyanjargal, Yunusova, Dilrabo, Zavaleta Pimentel, Nelly, Noormal, Bashir, Díaz, Virginia, Leroy, Charlotte, Roelens, Kristien, Agossou, M. Christian Urlyss, Tshabu Aguemon, Christiane, Apaza Peralta, Patricia Soledad, Conde Altamirano, Víctor, Batiene, Vincent, Cisse, Kadari, Cheang, Kannitha, Lam, Phirun, Simo, Elie, Yakana, Emah Irene, Carvajal, Javier, Fernández, Paula, Langhoff-Roos, Jens, Vélez, Paola, Sultan, Alaa, Teklu, Alula M., Worku, Dawit, Govule, Philip, Noora Lwanga, Charles, Flores Aceituno, María Guadalupe, Bustillo, Carolina, Lara, Bredy, Suri, Vanita, Trikha, Sonia, Cetin, Irene, Personeni, Carlo, Baimussanova, Guldana, Sagyndykova, Balgyn, Gwako, George, Osoti, Alfred, Asylbasheva, Raisa, Seksenbaeva, Damira, Itani, Saad Eddine, Abou Malham, Sabina, Ramašauskaitė, Diana, Chikhwaza, Owen, Malunga, Eddie, Dembele, Haoua, Zerbo, Fanta Eliane, Dávila Serapio, Filiberto, Islas Castañeda, Juan I., Cauaus, Tatiana, Petrov, Victor, Khishgee, Seded, Lkhagvasuren, Bat-Erdene, Essolbi, Amina, Moulki, Rachid, Jaze, Zara, Mariano, Arlete, Maung, Thae Maung, Gurung, Tara, Shrestha, Sangeeta, Rijken, Marcus J., Van Den Akker, Thomas, Estrada, María Esther, Pavón Gómez, Néstor J., Adesina, Olubukola, Aimakhu, Chris, Chaudhri, Rizwana, Khan, M. Adnan, Huatuco Hernández, María del Pilar, Andal, Maria Lu, Martin, Carolina Paula, Diouf, Léopold, Guirassy, Dembo, Borovsky, Miroslav, Kovac, Ladislav, Cornelissen, Laura, Soma-Pillay, Priya, López, Marta, Vidal Benedé, María José, Jayakody, Hemali, Nabag, Wisal, Omer, Sara, Tsoy, Victoria, Uzakova, Urunbish, Tangsiriwatthana, Thumwadee, Dunlop, Catherine, Roman, Jhon, Vitureira, Gerardo, Truong, Luong Ngoc, Hanh, Nghiem Thi Xuan, Madziyire, Mugove, Magwali, Thulani, Bartlett, Linda, Bellissimo-Rodrigues, Fernando, Jacob, Shevin T., Shakoor, Sadia, Yunis, Khalid, Campodónico, Liana, Gamerro, Hugo, Giordano, Daniel, Althabe, Fernando, Gülmezoglu, A. Metin, and Souza, João Paulo

Published
2020
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10. Cancer and Pregnancy: Estimates in Italy from Record-Linkage Procedures between Cancer Registries and the Hospital Discharge Database

Author

Pierannunzio, Daniela, primary, Maraschini, Alice, additional, Lopez, Tania, additional, Donati, Serena, additional, Amodio, Rosalba, additional, Bianconi, Fortunato, additional, Bruni, Rossella, additional, Castaing, Marine, additional, Cirilli, Claudia, additional, Fantaci, Giovanna, additional, Guarda, Linda, additional, Iacovacci, Silvia, additional, Mangone, Lucia, additional, Mazzoleni, Guido, additional, Mazzucco, Walter, additional, Melcarne, Anna, additional, Merlo, Elisabetta, additional, Parazzini, Fabio, additional, Peccatori, Fedro Alessandro, additional, Rugge, Massimo, additional, Sampietro, Giuseppe, additional, Scambia, Giovanni, additional, Scarfone, Giovanna, additional, Sferrazza, Ausilia, additional, Stracci, Fabrizio, additional, Torrisi, Antonina, additional, Vitale, Maria Francesca, additional, and Francisci, Silvia, additional

Published
2023
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12. Evolution of National Guidelines on Medicines Used to Treat COVID-19 in Pregnancy in 2020–2022: A Scoping Review

Author

Maisonneuve, Emeline, primary, de Bruin, Odette, additional, Favre, Guillaume, additional, Goncé, Anna, additional, Donati, Serena, additional, Engjom, Hilde, additional, Hurley, Eimir, additional, Al-Fadel, Nouf, additional, Siiskonen, Satu, additional, Bloemenkamp, Kitty, additional, Nordeng, Hedvig, additional, Sturkenboom, Miriam, additional, Baud, David, additional, and Panchaud, Alice, additional

Published
2023
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13. Vaccination against SARS-CoV-2 in pregnancy during the Omicron wave: the prospective cohort study of the Italian obstetric surveillance system

Author

Corsi Decenti, Edoardo, primary, Salvatore, Michele Antonio, additional, Mandolini, Donatella, additional, Donati, Serena, additional, Alberi, Irene, additional, Camandona, Franco, additional, Casucci, Paola, additional, Cetin, Irene, additional, Ciavattini, Andrea, additional, Damiani, Fabrizio, additional, Di Sebastiano, Francesca, additional, Driul, Lorenza, additional, Droghini, Fiorenza, additional, Ettore, Giuseppe, additional, Farsetti, Daniele, additional, Franchi, Massimo Piergiuseppe, additional, Leo, Livio, additional, Liberati, Marco, additional, Sacchi, Lucia Li, additional, Locci, Mariavittoria, additional, Martini, Claudio, additional, Maso, Gianpaolo, additional, Mecacci, Federico, additional, Meloni, Alessandra, additional, Mignuoli, Anna Domenica, additional, Mondo, Luisa, additional, Morano, Danila, additional, Paradiso, Rocco, additional, Perrone, Enrica, additional, Piccinno, Roberta, additional, Prefumo, Federico, additional, Ramenghi, Luca, additional, Rocca, Morena, additional, Sampaolo, Letizia, additional, Scalchi, Sabrina, additional, Antonio Schettini, Sergio Crescenzo, additional, Simeone, Daniela, additional, Simeone, Serena, additional, Steinkasserer, Martin, additional, Taddei, Fabrizio, additional, Tesorone, Marina, additional, Trojano, Vito, additional, Tronci, Caterina, additional, Veneziano, Micaela, additional, and Vimercati, Antonella, additional

Published
2023
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14. Postpartum haemorrhage in high‐resource settings: Variations in clinical management and future research directions based on a comparative study of national guidelines.

Author

de Vries, Pauline L. M., Deneux‐Tharaux, Catherine, Baud, David, Chen, Kenneth K., Donati, Serena, Goffinet, Francois, Knight, Marian, D'Souzah, Rohan, Sueters, Marieke, and van den Akker, Thomas

Subjects
POSTPARTUM hemorrhage, HIGH-income countries, COMPARATIVE studies, BLOOD transfusion, BLOOD transfusion reaction, SURGICAL blood loss
Abstract

Objective: To compare guidelines from eight high‐income countries on prevention and management of postpartum haemorrhage (PPH), with a particular focus on severe PPH. Design: Comparative study. Setting: High‐resource countries. Population: Women with PPH. Methods: Systematic comparison of guidance on PPH from eight high‐income countries. Main outcome measures: Definition of PPH, prophylactic management, measurement of blood loss, initial PPH‐management, second‐line uterotonics, non‐pharmacological management, resuscitation/transfusion management, organisation of care, quality/methodological rigour. Conclusions: Our study highlights areas where strong evidence is lacking. There is need for a universal definition of (severe) PPH. Consensus is required on how and when to quantify blood loss to identify PPH promptly. Future research may focus on timing and sequence of second‐line uterotonics and non‐pharmacological interventions and how these impact maternal outcome. Until more data are available, different transfusion strategies will be applied. The use of clear transfusion‐protocols are nonetheless recommended to reduce delays in initiation. There is a need for a collaborative effort to develop standardised, evidence‐based PPH guidelines. Results: Definitions of (severe) PPH varied as to the applied cut‐off of blood loss and incorporation of clinical parameters. Dose and mode of administration of prophylactic uterotonics and methods of blood loss measurement were heterogeneous. Recommendations on second‐line uterotonics differed as to type and dose. Obstetric management diverged particularly regarding procedures for uterine atony. Recommendations on transfusion approaches varied with different thresholds for blood transfusion and supplementation of haemostatic agents. Quality of guidelines varied considerably. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Incidence and outcomes of uterine rupture in women with unscarred, preterm or prelabour uteri: data from the international network of obstetric survey systems.

Author

Vandenberghe, Griet, Vierin, Anne, Bloemenkamp, Kitty, Berlage, Sylvia, Colmorn, Lotte, Deneux‐Tharaux, Catherine, Donati, Serena, Gissler, Mika, Knight, M., Langhoff‐Roos, Jens, Lindqvist, Pelle G., Maier, Barbara, van Roosmalen, Jos, Zwart, Joost, and Roelens, Kristien

Subjects
UTERINE rupture, UTERUS, PERINATAL death, HIGH-income countries
Abstract

Objective: Analysis of atypical cases of uterine rupture, namely, uterine rupture occurring in unscarred, preterm or prelabour uteri. Design: Descriptive multi‐country population‐based study. Setting: Ten high‐income countries within the International Network of Obstetric Survey Systems. Population: Women with unscarred, preterm or prelabour ruptured uteri. Methods: We merged prospectively collected individual patient data in ten population‐based studies of women with complete uterine rupture. In this analysis, we focused on women with uterine rupture of unscarred, preterm or prelabour ruptured uteri. Main Outcome Measures: Incidence, women's characteristics, presentation and maternal and perinatal outcome. Results: We identified 357 atypical uterine ruptures in 3 064 923 women giving birth. Estimated incidence was 0.2 per 10 000 women (95% CI 0.2–0.3) in the unscarred uteri, 0.5 (95% CI 0.5–0.6) in the preterm uteri, 0.7 (95% CI 0.6–0.8) in the prelabour uteri, and 0.5 (95% CI 0.4–0.5) in the group with no previous caesarean. Atypical uterine rupture resulted in peripartum hysterectomy in 66 women (18.5%, 95% CI 14.3–23.5%), three maternal deaths (0.84%, 95% CI 0.17–2.5%) and perinatal death in 62 infants (19.7%, 95% CI 15.1–25.3%). Conclusions: Uterine rupture in preterm, prelabour or unscarred uteri are extremely uncommon but were associated with severe maternal and perinatal outcome. We found a mix of risk factors in unscarred uteri, most preterm uterine ruptures occurred in caesarean‐scarred uteri and most prelabour uterine ruptures in 'otherwise' scarred uteri. This study may increase awareness among clinicians and raise suspicion of the possibility of uterine rupture under these less expected conditions. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Variations across Europe in hospitalization and management of pregnant women with SARS‐CoV‐2 during the initial phase of the pandemic: Multi‐national population‐based cohort study using the International Network of Obstetric Survey Systems (INOSS)

Author

de Bruin, Odette, Engjom, Hilde, Vousden, Nicola, Ramakrishnan, Rema, Aabakke, Anna J. M., Äyräs, Outi, Donati, Serena, Jónasdóttir, Eva, Knight, Marian, Overtoom, Evelien M., Salvatore, Michele A., Sturkenboom, Miriam C. J. M., Svanvik, Teresia, Varpula, Reetta, Vercoutere, An, and Bloemenkamp, Kitty W. M.

Subjects
PREGNANT women, SARS-CoV-2, COHORT analysis, THERAPEUTICS, DIAGNOSTIC use of polymerase chain reaction
Abstract

Introduction: The majority of data on COVID‐19 in pregnancy are not from sound population‐based active surveillance systems. Material and methods: We conducted a multi‐national study of population‐based national or regional prospective cohorts using standardized definitions within the International Network of Obstetric Survey systems (INOSS). From a source population of women giving birth between March 1 and August 31, 2020, we included pregnant women admitted to hospital with a positive SARS‐CoV‐2 PCR test ≤7 days prior to or during admission and up to 2 days after birth. The admissions were further categorized as COVID‐19‐related or non‐COVID‐19‐related. The primary outcome of interest was incidence of COVID‐19‐related hospital admission. Secondary outcomes included severe maternal disease (ICU admission and mechanical ventilation) and COVID‐19‐directed medical treatment. Results: In a source population of 816 628 maternities, a total of 2338 pregnant women were admitted with SARS‐CoV‐2; among them 940 (40%) were COVID‐19‐related admissions. The pooled incidence estimate for COVID‐19‐related admission was 0.59 (95% confidence interval 0.27–1.02) per 1000 maternities, with notable heterogeneity across countries (I2 = 97.3%, P = 0.00). In the COVID‐19 admission group, between 8% and 17% of the women were admitted to intensive care, and 5%–13% needed mechanical ventilation. Thromboprophylaxis was the most frequent treatment given during COVID‐19‐related admission (range 14%–55%). Among 908 infants born to women in the COVID‐19‐related admission group, 5 (0.6%) stillbirths were reported. Conclusions: During the initial months of the pandemic, we found substantial variations in incidence of COVID‐19‐related admissions in nine European countries. Few pregnant women received COVID‐19‐directed medical treatment. Several barriers to rapid surveillance were identified. Investment in robust surveillance should be prioritized to prepare for future pandemics. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Evolution of National Guidelines on Medicines Used to Treat COVID-19 in Pregnancy in 2020-2022: A Scoping Review

Author

Maisonneuve, Emeline, de Bruin, Odette, Favre, Guillaume, Goncé, Anna, Donati, Serena, Engjom, Hilde, Hurley, Eimir, Al-Fadel, Nouf, Siiskonen, Satu, Bloemenkamp, Kitty, Nordeng, Hedvig, Sturkenboom, Miriam, Baud, David, and Panchaud, Alice

Subjects
360 Social problems & social services, 610 Medicine & health
Abstract

The lack of inclusion of pregnant women in clinical trials evaluating the effectiveness of medicines to treat COVID-19 has made it difficult to establish evidence-based treatment guidelines for pregnant women. Our aim was to provide a review of the evolution and updates of the national guidelines on medicines used in pregnant women with COVID-19 published by the obstetrician and gynecologists' societies in thirteen countries in 2020-2022. Based on the results of the RECOVERY (Randomized Evaluation of COVID-19 Therapy) trial, the national societies successively recommended against prescribing hydroxychloroquine, lopinavir-ritonavir and azithromycin. Guidelines for remdesivir differed completely between countries, from compassionate or conditional use to recommendation against. Nirmatrelvir-ritonavir was authorized in Australia and the UK only in research settings and was no longer recommended in the UK at the end of 2022. After initial reluctance to use corticosteroids, the results of the RECOVERY trial have enabled the recommendation of dexamethasone in case of severe COVID-19 since mid-2020. Some societies recommended prescribing tocilizumab to pregnant patients with hypoxia and systemic inflammation from June 2021. Anti-SARS-CoV-2 monoclonal antibodies were authorized at the end of 2021 with conditional use in some countries, and then no longer recommended in Belgium and the USA at the end of 2022. The gradual convergence of the recommendations, although delayed compared to the general population, highlights the importance of the inclusion of pregnant women in clinical trials and of international collaboration to improve the pharmacological treatment of pregnant women with COVID-19.

Published
2023

20. Evolution of National Guidelines on Medicines Used to Treat COVID-19 in Pregnancy in 2020-2022: A Scoping Review

Author

Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, PECP - Centre for Pharmacoepidemiology, Maisonneuve, Emeline, de Bruin, Odette, Favre, Guillaume, Goncé, Anna, Donati, Serena, Engjom, Hilde, Hurley, Eimir, Al-Fadel, Nouf, Siiskonen, Satu, Bloemenkamp, Kitty, Nordeng, Hedvig, Sturkenboom, Miriam, Baud, David, Panchaud, Alice, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, PECP - Centre for Pharmacoepidemiology, Maisonneuve, Emeline, de Bruin, Odette, Favre, Guillaume, Goncé, Anna, Donati, Serena, Engjom, Hilde, Hurley, Eimir, Al-Fadel, Nouf, Siiskonen, Satu, Bloemenkamp, Kitty, Nordeng, Hedvig, Sturkenboom, Miriam, Baud, David, and Panchaud, Alice

Published
2023

21. Variations across Europe in hospitalization and management of pregnant women with SARS-CoV-2 during the initial phase of the pandemic:Multi-national population-based cohort study using the International Network of Obstetric Survey Systems (INOSS)

Author

de Bruin, Odette, Engjom, Hilde, Vousden, Nicola, Ramakrishnan, Rema, Aabakke, Anna J.M., Äyräs, Outi, Donati, Serena, Jónasdóttir, Eva, Knight, Marian, Overtoom, Evelien M., Salvatore, Michele A., Sturkenboom, Miriam C.J.M., Svanvik, Teresia, Varpula, Reetta, Vercoutere, An, Bloemenkamp, Kitty W.M., de Bruin, Odette, Engjom, Hilde, Vousden, Nicola, Ramakrishnan, Rema, Aabakke, Anna J.M., Äyräs, Outi, Donati, Serena, Jónasdóttir, Eva, Knight, Marian, Overtoom, Evelien M., Salvatore, Michele A., Sturkenboom, Miriam C.J.M., Svanvik, Teresia, Varpula, Reetta, Vercoutere, An, and Bloemenkamp, Kitty W.M.

Abstract

Introduction: The majority of data on COVID-19 in pregnancy are not from sound population-based active surveillance systems. Material and methods: We conducted a multi-national study of population-based national or regional prospective cohorts using standardized definitions within the International Network of Obstetric Survey systems (INOSS). From a source population of women giving birth between March 1 and August 31, 2020, we included pregnant women admitted to hospital with a positive SARS-CoV-2 PCR test ≤7 days prior to or during admission and up to 2 days after birth. The admissions were further categorized as COVID-19-related or non-COVID-19-related. The primary outcome of interest was incidence of COVID-19-related hospital admission. Secondary outcomes included severe maternal disease (ICU admission and mechanical ventilation) and COVID-19-directed medical treatment. Results: In a source population of 816 628 maternities, a total of 2338 pregnant women were admitted with SARS-CoV-2; among them 940 (40%) were COVID-19-related admissions. The pooled incidence estimate for COVID-19-related admission was 0.59 (95% confidence interval 0.27–1.02) per 1000 maternities, with notable heterogeneity across countries (I2 = 97.3%, P = 0.00). In the COVID-19 admission group, between 8% and 17% of the women were admitted to intensive care, and 5%–13% needed mechanical ventilation. Thromboprophylaxis was the most frequent treatment given during COVID-19-related admission (range 14%–55%). Among 908 infants born to women in the COVID-19-related admission group, 5 (0.6%) stillbirths were reported. Conclusions: During the initial months of the pandemic, we found substantial variations in incidence of COVID-19-related admissions in nine European countries. Few pregnant women received COVID-19-directed medical treatment. Several barriers to rapid surveillance were identified. Investment in robust surveillance should be prioritized to prepare for future pandemics.

Published
2023

22. Evolution of National Guidelines on Medicines Used to Treat COVID-19 in Pregnancy in 2020-2022: A Scoping Review

Author

MS Verloskunde, Child Health, Data Science & Biostatistiek, Maisonneuve, Emeline, de Bruin, Odette, Favre, Guillaume, Goncé, Anna, Donati, Serena, Engjom, Hilde, Hurley, Eimir, Al-Fadel, Nouf, Siiskonen, Satu, Bloemenkamp, Kitty, Nordeng, Hedvig, Sturkenboom, Miriam, Baud, David, Panchaud, Alice, MS Verloskunde, Child Health, Data Science & Biostatistiek, Maisonneuve, Emeline, de Bruin, Odette, Favre, Guillaume, Goncé, Anna, Donati, Serena, Engjom, Hilde, Hurley, Eimir, Al-Fadel, Nouf, Siiskonen, Satu, Bloemenkamp, Kitty, Nordeng, Hedvig, Sturkenboom, Miriam, Baud, David, and Panchaud, Alice

Published
2023

24. A large series of molecular and serological specimens to evaluate mother-to-child SARS-CoV-2 transmission: a prospective study from the Italian Obstetric Surveillance System

Author

Corsi Decenti, Edoardo, primary, Salvatore, Michele Antonio, additional, Mancon, Alessandro, additional, Portella, Giuseppe, additional, Rocca, Arianna, additional, Vocale, Caterina, additional, Donati, Serena, additional, Alberi, Irene, additional, Anelli, Gaia Maria, additional, Baltaro, Federica, additional, Bisulli, Maria, additional, Brusa, Stefano, additional, Cataneo, Ilaria, additional, Cetin, Irene, additional, Cuomo, Marianna, additional, Rì, Pietro Dal, additional, Cerbo, Lidia Di, additional, Ferretti, Alice, additional, Gismondo, Maria Rita, additional, Grisolia, Gianpaolo, additional, Livio, Stefania, additional, Locci, Mariavittoria, additional, Malentacchi, Francesca, additional, Mecacci, Federico, additional, Paccaloni, Barbara, additional, Pedna, Maria Federica, additional, Perrone, Enrica, additional, Pignatti, Lucrezia, additional, Piras, Martina, additional, Primavera, Alessandra, additional, Savasi, Valeria, additional, Simeone, Serena, additional, Taddei, Fabrizio, additional, Tironi, Roberta, additional, and Torri, Arianna, additional

Published
2023
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25. Maternal mortality in eight European countries with enhanced surveillance systems: descriptive population based study

Author

Diguisto, Caroline, primary, Saucedo, Monica, additional, Kallianidis, Athanasios, additional, Bloemenkamp, Kitty, additional, Bødker, Birgit, additional, Buoncristiano, Marta, additional, Donati, Serena, additional, Gissler, Mika, additional, Johansen, Marianne, additional, Knight, Marian, additional, Korbel, Miroslav, additional, Kristufkova, Alexandra, additional, Nyflot, Lill T, additional, and Deneux-Tharaux, Catherine, additional

Published
2022
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29. Monitoring medicine prescriptions before, during and after pregnancy in Italy.

Author

Fortinguerra, Filomena, Belleudi, Valeria, Poggi, Francesca Romana, Perna, Serena, Bortolus, Renata, Donati, Serena, D'Aloja, Paola, Da Cas, Roberto, Clavenna, Antonio, Locatelli, Anna, Addis, Antonio, Davoli, Marina, and Trotta, Francesco

Subjects
HEPARIN, PREGNANT women, PREGNANCY, DRUG prescribing, FOLIC acid, CLINICAL medicine, FETAL monitoring
Abstract

Background: The use of medications during pregnancy is a common event worldwide. Monitoring medicine prescriptions in clinical practice is a necessary step in assessing the impact of therapeutic choices in pregnant women as well as the adherence to clinical guidelines. The aim of this study was to provide prevalence data on medication use before, during and after pregnancy in the Italian population. Methods: A retrospective prevalence study using administrative healthcare databases was conducted. A cohort of 449,012 pregnant women (15–49 years) residing in eight Italian regions (59% of national population), who delivered in 2016–2018, were enrolled. The prevalence of medication use was estimated as the proportion (%) of pregnant women with any prescription. Results: About 73.1% of enrolled women received at least one drug prescription during pregnancy, 57.1% in pre-pregnancy and 59.3% in postpartum period. The prevalence of drug prescriptions increased with maternal age, especially during the 1st trimester of pregnancy. The most prescribed medicine was folic acid (34.6%), followed by progesterone (19%), both concentrated in 1st trimester of pregnancy (29.2% and 14.8%, respectively). Eight of the top 30 most prescribed medications were antibiotics, whose prevalence was higher during 2nd trimester of pregnancy in women ≥ 40 years (21.6%). An increase in prescriptions of anti-hypertensives, antidiabetics, thyroid hormone and heparin preparations was observed during pregnancy; on the contrary, a decrease was found for chronic therapies, such as anti-epileptics or lipid-modifying agents. Conclusions: This study represents the largest and most representative population-based study illustrating the medication prescription patterns before, during and after pregnancy in Italy. The observed prescriptive trends were comparable to those reported in other European countries. Given the limited information on medication use in Italian pregnant women, the performed analyses provide an updated overview of drug prescribing in this population, which can help to identify critical aspects in clinical practice and to improve the medical care of pregnant and childbearing women in Italy. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Population birth data and pandemic readiness in Europe

Author

Haidinger, Gerald, Klimont, Jeannette, Alexander, Sophie, Zhang, Wei-Hong, Vandervelpen, Ele, Delnord, Marie, Kolarova, Rumyana, Yordanova, Evelin, Rodin, Urelija, Drausnik, Zeljka, Filipovic-Grcic, Boris, Kyprianou, Theopisti, Scoutellas, Vasos, Velebil, Petr, Mortensen, Laust Hvas, Sakkeus, Luule, Abuladze, Liili, Gissler, Mika, Blondel, Beatrice, Deneux-Tharaux, Catherine, Durox, Melanie, Philibert, Marianne, Zeitlin, Jennifer, Fresson, Jeanne, Heller, Guenther, Misselwitz, Bjoern, Antsaklis, Aris, Berbik, Istvan, Olafsdottir, Helga Sol, Kearns, Karen, Sikora, Izabela, Cuttini, Marina, Loghi, Marzia, Donati, Serena, Boldrini, Rosalia, Misins, Janis, Zile, Irisa, Isakova, Jelena, Touvrey-Lecomte, Aline, Billy, Audrey, Couffignal, Sophie, Weber, Guy, Gatt, Miriam, Nijhuis, Jan, Broeders, Lisa, Achterberg, P. W., Hindori-Mohangoo, Ashna, Klungsoyr, Kari, Akerkar, Rupali, Engjom, Hilde, Szamotulska, Katarzyna, Mierzejewska, Ewa, Barros, Henrique, Rodrigues, Carina, Horga, Mihai, Tica, Vlad, Puscasiu, Lucian, Budianu, Mihaela-Alexandra, Cucu, Alexandra, Calomfirescu, Cristian, Cap, Jan, Mandic, Natasa Tul, Verdenik, Ivan, Zurriaga, Oscar, Alcaide, Adela Recio, Jane, Mireia, Vidal, Maria Jose, Kallen, Karin, Nyman, Anastasia, Rihs, Tonia, Macfarlane, Alison, Wood, Rachael, Monteath, Kirsten, Smith, Lucy, Morgan, Siobhan, Hillen, Jennifer, Haidinger, Gerald, Klimont, Jeannette, Alexander, Sophie, Zhang, Wei-Hong, Vandervelpen, Ele, Delnord, Marie, Kolarova, Rumyana, Yordanova, Evelin, Rodin, Urelija, Drausnik, Zeljka, Filipovic-Grcic, Boris, Kyprianou, Theopisti, Scoutellas, Vasos, Velebil, Petr, Mortensen, Laust Hvas, Sakkeus, Luule, Abuladze, Liili, Gissler, Mika, Blondel, Beatrice, Deneux-Tharaux, Catherine, Durox, Melanie, Philibert, Marianne, Zeitlin, Jennifer, Fresson, Jeanne, Heller, Guenther, Misselwitz, Bjoern, Antsaklis, Aris, Berbik, Istvan, Olafsdottir, Helga Sol, Kearns, Karen, Sikora, Izabela, Cuttini, Marina, Loghi, Marzia, Donati, Serena, Boldrini, Rosalia, Misins, Janis, Zile, Irisa, Isakova, Jelena, Touvrey-Lecomte, Aline, Billy, Audrey, Couffignal, Sophie, Weber, Guy, Gatt, Miriam, Nijhuis, Jan, Broeders, Lisa, Achterberg, P. W., Hindori-Mohangoo, Ashna, Klungsoyr, Kari, Akerkar, Rupali, Engjom, Hilde, Szamotulska, Katarzyna, Mierzejewska, Ewa, Barros, Henrique, Rodrigues, Carina, Horga, Mihai, Tica, Vlad, Puscasiu, Lucian, Budianu, Mihaela-Alexandra, Cucu, Alexandra, Calomfirescu, Cristian, Cap, Jan, Mandic, Natasa Tul, Verdenik, Ivan, Zurriaga, Oscar, Alcaide, Adela Recio, Jane, Mireia, Vidal, Maria Jose, Kallen, Karin, Nyman, Anastasia, Rihs, Tonia, Macfarlane, Alison, Wood, Rachael, Monteath, Kirsten, Smith, Lucy, Morgan, Siobhan, and Hillen, Jennifer

Published
2022

33. Maternal mortality in eight European countries with enhanced surveillance systems: Descriptive population based study

Author

MS Verloskunde, Child Health, Geboortecentrum voorzitterschap, Diguisto, Caroline, Saucedo, Monica, Kallianidis, Athanasios, Bloemenkamp, Kitty, Bødker, Birgit, Buoncristiano, Marta, Donati, Serena, Gissler, Mika, Johansen, Marianne, Knight, Marian, Korbel, Miroslav, Kristufkova, Alexandra, Nyflot, Lill T., Deneux-Tharaux, Catherine, MS Verloskunde, Child Health, Geboortecentrum voorzitterschap, Diguisto, Caroline, Saucedo, Monica, Kallianidis, Athanasios, Bloemenkamp, Kitty, Bødker, Birgit, Buoncristiano, Marta, Donati, Serena, Gissler, Mika, Johansen, Marianne, Knight, Marian, Korbel, Miroslav, Kristufkova, Alexandra, Nyflot, Lill T., and Deneux-Tharaux, Catherine

Published
2022

34. Severe COVID-19 in pregnancy is almost exclusively limited to unvaccinated women – time for policies to change

Author

Geboortecentrum voorzitterschap, Child Health, MS Verloskunde, Engjom, Hilde, van den Akker, Thomas, Aabakke, Anna, Ayras, Outi, Bloemenkamp, Kitty, Donati, Serena, Cereda, Danilo, Overtoom, Evelien, Knight, Marian, Geboortecentrum voorzitterschap, Child Health, MS Verloskunde, Engjom, Hilde, van den Akker, Thomas, Aabakke, Anna, Ayras, Outi, Bloemenkamp, Kitty, Donati, Serena, Cereda, Danilo, Overtoom, Evelien, and Knight, Marian

Published
2022

36. The Psychological Impact of COVID-19 among Women Accessing Family Care Centers during Pregnancy and the Postnatal Period in Italy

Author

Lega, Ilaria, primary, Bramante, Alessandra, additional, Lauria, Laura, additional, Grussu, Pietro, additional, Dubini, Valeria, additional, Falcieri, Marcella, additional, Ghiani, Maria Carmen, additional, Giordano, Antonia, additional, Guidomei, Stefania, additional, Mignuoli, Anna Domenica, additional, Paris, Serena, additional, Bettinelli, Maria Enrica, additional, Proietti, Patrizia, additional, Andreozzi, Silvia, additional, Brenna, Valeria, additional, Bucciarelli, Mauro, additional, Martelli, Gabriella, additional, Ferraro, Claudia, additional, Torrisi, Melissa, additional, Carrozzino, Danilo, additional, and Donati, Serena, additional

Published
2022
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38. Population birth data and pandemic readiness in Europe

Author

Haidinger, Gerald Klimont, Jeannette Alexander, Sophie and Zhang, Wei-Hong Vandervelpen, Ele Delnord, Marie Kolarova, Rumyana Yordanova, Evelin Rodin, Urelija Drausnik, Zeljka and Filipovic-Grcic, Boris Kyprianou, Theopisti Scoutellas, Vasos Velebil, Petr Mortensen, Laust Hvas Sakkeus, Luule and Abuladze, Liili Gissler, Mika Blondel, Beatrice and Deneux-Tharaux, Catherine Durox, Melanie Philibert, Marianne and Zeitlin, Jennifer Fresson, Jeanne Heller, Guenther and Misselwitz, Bjoern Antsaklis, Aris Berbik, Istvan and Olafsdottir, Helga Sol Kearns, Karen Sikora, Izabela and Cuttini, Marina Loghi, Marzia Donati, Serena Boldrini, Rosalia Misins, Janis Zile, Irisa Isakova, Jelena and Touvrey-Lecomte, Aline Billy, Audrey Couffignal, Sophie and Weber, Guy Gatt, Miriam Nijhuis, Jan Broeders, Lisa and Achterberg, P. W. Hindori-Mohangoo, Ashna Klungsoyr, Kari and Akerkar, Rupali Engjom, Hilde Szamotulska, Katarzyna and Mierzejewska, Ewa Barros, Henrique Rodrigues, Carina Horga, Mihai Tica, Vlad Puscasiu, Lucian Budianu, Mihaela-Alexandra and Cucu, Alexandra Calomfirescu, Cristian Cap, Jan Mandic, Natasa Tul Verdenik, Ivan Zurriaga, Oscar Alcaide, Adela Recio Jane, Mireia Vidal, Maria Jose Kallen, Karin and Nyman, Anastasia Rihs, Tonia Macfarlane, Alison Wood, Rachael Monteath, Kirsten Smith, Lucy Morgan, Siobhan and Hillen, Jennifer Euro-Peristat Res Network

Published
2022

39. Childbirth care among sars-cov-2 positive women in Italy

Author

Donati, Serena, Corsi, Edoardo, Salvatore, Michele, Maraschini, Alice, Bonassisa, Silvia, Casucci, Paola, Cataneo, Ilaria, Cetin, Irene, D’Aloja, Paola, Dardanoni, Gabriella, Ambrosi, Elena De, Ferrazzi, Enrico, Fieni, Stefania, Franchi, Massimo, Gargantini, Gianluigi, Iurlaro, Enrico, Leo, Livio, Liberati, Marco, Livio, Stefania, Locci, Mariavittoria, Marozio, Luca, Martini, Claudio, Maso, Gianpaolo, Mecacci, Federico, Meloni, Alessandra, Mignuoli, Anna, Patanè, Luisa, Pellegrini, Edda, Perotti, Francesca, Perrone, Enrica, Prefumo, Federico, Ramenghi, Luca, Rusciani, Raffaella, Savasi, Valeria, Schettini, Sergio, Simeone, Daniela, Simeone, Serena, Spinillo, Arsenio, Steinkasserer, Martin, Tateo, Saverio, Ternelli, Giliana, Tironi, Roberta, Trojano, Vito, Vergani, Patrizia, Zullino, Sara, Group, on behalf of the ItOSS COVID-19 Working, Donati, Serena, Corsi, Edoardo, Salvatore, Michele Antonio, Maraschini, Alice, Bonassisa, Silvia, Casucci, Paola, Cataneo, Ilaria, Cetin, Irene, D'Aloja, Paola, Dardanoni, Gabriella, De Ambrosi, Elena, Ferrazzi, Enrico, Fieni, Stefania, Franchi, Massimo Piergiuseppe, Gargantini, Gianluigi, Iurlaro, Enrico, Leo, Livio, Liberati, Marco, Livio, Stefania, Locci, Mariavittoria, Marozio, Luca, Martini, Claudio, Maso, Gianpaolo, Mecacci, Federico, Meloni, Alessandra, Mignuoli, Anna Domenica, Patanè, Luisa, Pellegrini, Edda, Perotti, Francesca, Perrone, Enrica, Prefumo, Federico, Ramenghi, Luca, Rusciani, Raffaella, Savasi, Valeria, Schettini, Sergio Crescenzo Antonio, Simeone, Daniela, Simeone, Serena, Spinillo, Arsenio, Steinkasserer, Martin, Tateo, Saverio, Ternelli, Giliana, Tironi, Roberta, Trojano, Vito, Vergani, Patrizia, Zullino, Sara, Donati, S, Corsi, E, Salvatore, M, Maraschini, A, Bonassisa, S, Casucci, P, Cataneo, I, Cetin, I, D'Aloja, P, Dardanoni, G, De Ambrosi, E, Ferrazzi, E, Fieni, S, Franchi, M, Gargantini, G, Iurlaro, E, Leo, L, Liberati, M, Livio, S, Locci, M, Marozio, L, Martini, C, Maso, G, Mecacci, F, Meloni, A, Mignuoli, A, Patane, L, Pellegrini, E, Perotti, F, Perrone, E, Prefumo, F, Ramenghi, L, Rusciani, R, Savasi, V, Schettini, S, Simeone, D, Simeone, S, Spinillo, A, Steinkasserer, M, Tateo, S, Ternelli, G, Tironi, R, Trojano, V, Vergani, P, and Zullino, S

Subjects
Perinatal care, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Infectious Disease Transmission, Breastfeeding, 0302 clinical medicine, Pregnancy, Health care, Childbirth, Vertical, 030212 general & internal medicine, Prospective Studies, Pregnancy Complications, Infectious, Prospective cohort study, Child, education.field_of_study, 030219 obstetrics & reproductive medicine, Obstetrics, Infectious, Italy, Cohort, Medicine, Female, Human, medicine.medical_specialty, Population, Article, 03 medical and health sciences, medicine, Humans, Caesarean section, education, business.industry, SARS-CoV-2, Cesarean Section, Public Health, Environmental and Occupational Health, Infant, Newborn, COVID-19, Infant, medicine.disease, Newborn, Infectious Disease Transmission, Vertical, Pregnancy Complications, Prospective Studie, Birth, business
Abstract

The new coronavirus emergency spread to Italy when little was known about the infection’s impact on mothers and newborns. This study aims to describe the extent to which clinical practice has protected childbirth physiology and preserved the mother–child bond during the first wave of the pandemic in Italy. A national population-based prospective cohort study was performed enrolling women with confirmed SARS-CoV-2 infection admitted for childbirth to any Italian hospital from 25 February to 31 July 2020. All cases were prospectively notified, and information on peripartum care (mother–newborn separation, skin-to-skin contact, breastfeeding, and rooming-in) and maternal and perinatal outcomes were collected in a structured form and entered in a web-based secure system. The paper describes a cohort of 525 SARS-CoV-2 positive women who gave birth. At hospital admission, 44.8% of the cohort was asymptomatic. At delivery, 51.9% of the mothers had a birth support person in the delivery room, the average caesarean section rate of 33.7% remained stable compared to the national figure. On average, 39.0% of mothers were separated from their newborns at birth, 26.6% practised skin-to-skin, 72.1% roomed in with their babies, and 79.6% of the infants received their mother’s milk. The infants separated and not separated from their SARS-CoV-2 positive mothers both had good outcomes. At the beginning of the pandemic, childbirth raised awareness and concern due to limited available evidence and led to “better safe than sorry” care choices. An improvement of the peripartum care indicators was observed over time.

Published
2021

40. Methods to estimate maternal mortality: a global perspective

Author

Donati, Serena, Maraschini, Alice, Buoncristiano, Marta, Asole, Simona, Basevi, Vittorio, Da Frè, Monica, Dardanoni, Gabriella, Di Lallo, Domenico, Dubini, Valeria, Lupi, Camilla, Mondo, Luisa, Pezzella, Marcello, Pizzuti, Renato, Polo, Arianna, Rusciani, Raffaella, Spettoli, Daniela, and Voller, Fabio

Published
2016
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41. Maternal Sepsis in Italy: A Prospective, Population-Based Cohort and Nested Case-Control Study.

Author

Ornaghi, Sara, Maraschini, Alice, Buoncristiano, Marta, Corsi Decenti, Edoardo, Colciago, Elisabetta, Cetin, Irene, and Donati, Serena

Subjects
SEPSIS, URINARY tract infections, ESCHERICHIA coli, CASE-control method, IMPLANTABLE catheters, SYMPTOMS
Abstract

Maternal sepsis represents a leading cause of mortality and severe morbidity worldwide. In Italy, it is the second cause of direct maternal mortality. Delay in recognition and treatment initiation are the drivers of sepsis-associated adverse outcomes. Between November 2017 and October 2019, the Italian Obstetric Surveillance System coordinated a prospective population-based study on maternal sepsis occurring before or after childbirth from 22 weeks' gestation onward and up to 42 days following the end of pregnancy. A nested 1:2 matched case-control study on postpartum sepsis was also performed. Maternal sepsis was diagnosed for the presence of suspected or confirmed infection alongside signs or symptoms of organ failure. The aim of this study was to assess maternal sepsis incidence and its associated risk factors, management, and perinatal outcomes. Six Italian regions, covering 48.2% of the national births, participated in the project. We identified an incidence rate of 5.5 per 10,000 maternities (95% CI 4.80–6.28). Seventy percent of patients had a low education level and one third were foreigners with a language barrier. Genital, respiratory, and urinary tract infections were the predominant sources of infection; the majority of cases was caused by E. coli and polymicrobial infections. The presence of vascular and indwelling bladder catheters was associated with a nine-fold increased risk of postpartum sepsis. There were no maternal deaths, but one fourth of women experienced a serious adverse event and 28.3% required intensive care; 1.8% of newborns died. Targeted interventions to increase awareness of maternal sepsis and its risk factors and management should be promoted. [ABSTRACT FROM AUTHOR]

Published
2023
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44. A total blood volume or more transfused during pregnancy or after childbirth: Individual patient data from six international population-based observational studies

Author

Geboortecentrum voorzitterschap, Child Health, McCall, Stephen J., Henriquez, Dacia, Edwards, Hellen Mc Kinnon, Van Den Akker, Thomas, Bloemenkamp, Kitty W.M., Van Der Bom, Johanna, Bonnet, Marie Pierre, Deneux-Tharaux, Catherine, Donati, Serena, Gillissen, Ada, Kurinczuk, Jennifer J., Li, Zhuoyang, Maraschini, Alice, Seco, Aurelien, Sullivan, Elizabeth, Stanworth, Simon, Knight, Marian, Geboortecentrum voorzitterschap, Child Health, McCall, Stephen J., Henriquez, Dacia, Edwards, Hellen Mc Kinnon, Van Den Akker, Thomas, Bloemenkamp, Kitty W.M., Van Der Bom, Johanna, Bonnet, Marie Pierre, Deneux-Tharaux, Catherine, Donati, Serena, Gillissen, Ada, Kurinczuk, Jennifer J., Li, Zhuoyang, Maraschini, Alice, Seco, Aurelien, Sullivan, Elizabeth, Stanworth, Simon, and Knight, Marian

Published
2021

45. Placental Characteristics of a Large Italian Cohort of SARS-CoV-2-Positive Pregnant Women.

Author

Salvatore, Michele Antonio, Corsi Decenti, Edoardo, Bonasoni, Maria Paola, Botta, Giovanni, Castiglione, Francesca, D'Armiento, Maria, Fulcheri, Ezio, Nebuloni, Manuela, and Donati, Serena

Subjects
COVID-19, PREGNANT women, PLACENTA, SARS-CoV-2, CYTOKINE release syndrome, COVID-19 pandemic
Abstract

The variety of placental morphological findings with SARS-CoV-2 maternal infections has raised the issue of poor agreement in histopathological evaluation. The aims of this study were: to describe the histopathological placental features of a large sample of SARS-CoV-2-positive women who gave birth in Italy during the COVID-19 pandemic, to analyse the factors underlying these lesions, and to analyse the impact of placental impairment on perinatal outcomes. From 25 February 2020 to 30 June 2021, experienced perinatal pathologists examined 975 placentas of SARS-CoV-2-positive mothers enrolled in a national prospective study, adopting the Amsterdam Consensus Statement protocol. The main results included the absence of specific pathological findings for SARS-CoV-2 infections, even though a high proportion of placentas showed signs of inflammation, possibly related to a cytokine storm induced by the virus, without significant perinatal consequences. Further research is needed to better define the clinical implications of placental morphology in SARS-CoV-2 infections, but the results of this large cohort suggest that placentas do not seem to be a preferential target for the new Coronavirus infection. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Childbirth Care among SARS-CoV-2 Positive Women in Italy

Author

Donati, Serena, primary, Corsi, Edoardo, additional, Salvatore, Michele Antonio, additional, Maraschini, Alice, additional, Bonassisa, Silvia, additional, Casucci, Paola, additional, Cataneo, Ilaria, additional, Cetin, Irene, additional, D’Aloja, Paola, additional, Dardanoni, Gabriella, additional, De Ambrosi, Elena, additional, Ferrazzi, Enrico, additional, Fieni, Stefania, additional, Franchi, Massimo Piergiuseppe, additional, Gargantini, Gianluigi, additional, Iurlaro, Enrico, additional, Leo, Livio, additional, Liberati, Marco, additional, Livio, Stefania, additional, Locci, Mariavittoria, additional, Marozio, Luca, additional, Martini, Claudio, additional, Maso, Gianpaolo, additional, Mecacci, Federico, additional, Meloni, Alessandra, additional, Mignuoli, Anna Domenica, additional, Patanè, Luisa, additional, Pellegrini, Edda, additional, Perotti, Francesca, additional, Perrone, Enrica, additional, Prefumo, Federico, additional, Ramenghi, Luca, additional, Rusciani, Raffaella, additional, Savasi, Valeria, additional, Schettini, Sergio Crescenzo Antonio, additional, Simeone, Daniela, additional, Simeone, Serena, additional, Spinillo, Arsenio, additional, Steinkasserer, Martin, additional, Tateo, Saverio, additional, Ternelli, Giliana, additional, Tironi, Roberta, additional, Trojano, Vito, additional, Vergani, Patrizia, additional, and Zullino, Sara, additional

Published
2021
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48. SENZA CONFINI Come ridisegnare le cure per l’infanzia e l’adolescenza, integrando i servizi, promuovendo l’equità, diffondendo le eccellenze. A cura di: Centro per la Salute del Bambino (CSB), Associazione Culturale Pediatri (ACP)

Author

Tamburlini, Giorgio, Mario, Simona Di, Gangemi, Michele, Zanetto, Federica, Speri, Leonardo, Baronciani, Dante, Manetti, Stefania, Toffol, Giacomo, Brunelli, Antonella, Rapisardi, Gherardo, Pedrotti, Anna, Donati, Serena, Giusti, Angela, Pizzi, Enrica, Marchetti, Federico, Pediatria Di Gruppo Piccolo Principe Modena, Coscia, Alessandra, and Farneti, Massimo

Published
2020
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49. Frequency and management of maternal infection in health facilities in 52 countries (GLOSS): a 1-week inception cohort study

Author

Geboortecentrum voorzitterschap, Child Health, MS Verloskunde, Bonet, Mercedes, Brizuela, Vanessa, Abalos, Edgardo, Cuesta, Cristina, Baguiya, Adama, Chamillard, Mónica, Fawole, Bukola, Knight, Marian, Kouanda, Seni, Lumbiganon, Pisake, Nabhan, Ashraf, Nadisauskiene, Ruta J., Abdulkadir, Abdulfetah, Adanu, Richard MK, Aman, Mohammad Iqbal, Arriaga Romero, William E., Assarag, Bouchra, Bloemenkamp, Kitty W.M., Boobekova, Aigul, Budianu, Mihaela A., Cararach, Vicenç, Castro, Rigoberto, Cebekhulu, Sylvia, Cecatti, José Guilherme, Colmorn, Lotte Berdiin, Curteanu, Ala, Donati, Serena, Einda, Hla Mya Thway, El Deen, Yasser Salah, El Kak, Faysal, Elsheikh, Mohamed, Escobar-Vidarte, Maria F., Espinoza, Marisa Mabel, Estrada, María Ester, Gadama, Luis Aaron, Goufodji, Sourou B., Hamid, Saima, Hernandez Munoz, Rosalinda, Herrera Maldonado, Nazarea, Jayaratne, Kapila, Kabylova, Saule, Kristufkova, Alexandra, Kumar, Vijay, Lissauer, David, Mereci, Wilson, Minkauskiene, Meile, Moreira, Philippe, Munjanja, Stephen, Osman, Nafissa B., Rijken, Marcus J., Geboortecentrum voorzitterschap, Child Health, MS Verloskunde, Bonet, Mercedes, Brizuela, Vanessa, Abalos, Edgardo, Cuesta, Cristina, Baguiya, Adama, Chamillard, Mónica, Fawole, Bukola, Knight, Marian, Kouanda, Seni, Lumbiganon, Pisake, Nabhan, Ashraf, Nadisauskiene, Ruta J., Abdulkadir, Abdulfetah, Adanu, Richard MK, Aman, Mohammad Iqbal, Arriaga Romero, William E., Assarag, Bouchra, Bloemenkamp, Kitty W.M., Boobekova, Aigul, Budianu, Mihaela A., Cararach, Vicenç, Castro, Rigoberto, Cebekhulu, Sylvia, Cecatti, José Guilherme, Colmorn, Lotte Berdiin, Curteanu, Ala, Donati, Serena, Einda, Hla Mya Thway, El Deen, Yasser Salah, El Kak, Faysal, Elsheikh, Mohamed, Escobar-Vidarte, Maria F., Espinoza, Marisa Mabel, Estrada, María Ester, Gadama, Luis Aaron, Goufodji, Sourou B., Hamid, Saima, Hernandez Munoz, Rosalinda, Herrera Maldonado, Nazarea, Jayaratne, Kapila, Kabylova, Saule, Kristufkova, Alexandra, Kumar, Vijay, Lissauer, David, Mereci, Wilson, Minkauskiene, Meile, Moreira, Philippe, Munjanja, Stephen, Osman, Nafissa B., and Rijken, Marcus J.

Published
2020

50. A total blood volume or more transfused during pregnancy or after childbirth: Individual patient data from six international population-based observational studies

Author

McCall, Stephen J., primary, Henriquez, Dacia, additional, Edwards, Hellen McKinnon, additional, van den Akker, Thomas, additional, Bloemenkamp, Kitty W. M., additional, van der Bom, Johanna, additional, Bonnet, Marie-Pierre, additional, Deneux-Tharaux, Catherine, additional, Donati, Serena, additional, Gillissen, Ada, additional, Kurinczuk, Jennifer J., additional, Li, Zhuoyang, additional, Maraschini, Alice, additional, Seco, Aurélien, additional, Sullivan, Elizabeth, additional, Stanworth, Simon, additional, and Knight, Marian, additional

Published
2021
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