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The present article focuses upon particular findings from a mixed-methods study that examined the leadership strategies Antiguan school principals employed to incorporate technology into the teaching and learning process. The aim was to provide greater insight into these strategies, as well as, to identify some of the successes and challenges associated with the incorporation of ICT by these secondary school principals. This study was anchored by the International Standards for Technology in Education (ISTE) model, an established technology leadership theoretical framework. Qualitative data were gathered from school principals and teachers through the use of semistructured interviews (N=27). Furthermore, the qualitative data were manually coded and subjected to thematic content analysis. Regarding ICT integration, findings on leadership strategies highlighted a number of developing themes related to successes and challenges, in areas such as communication with key stakeholders, ICT resource allocation, attitude of educators towards ICT integration, and administrative activities.

The Good Behavior Game (GBG) is an effective procedure for reducing disruptive classroom behavior. Students in three fifth-grade classes selected the rules of the GBG and then experienced the GBG with different forms of feedback for rule violations (vocal and visual, vocal only, visual only, no feedback). Following an initial baseline, the four feedback versions of the GBG and a baseline condition were alternated across sessions in a multielement design. All versions of the GBG substantially reduced disruptive behavior below baseline levels. Additionally, in one of the three classes losing the GBG produced an increase in negative peer interactions immediately following the GBG. Following the multielement comparison, we implemented a group-arrangement concurrent-chains preference assessment in which students selected one of the conditions to experience each day. The most selected condition across all classes was the GBG condition, which included both vocal and visual feedback.

Making mistakes and receiving feedback are crucial elements of learning. Reading picturebooks with young children can help shape their perceptions of mistakes and model adaptive responses they can emulate, both in the short term and for years to come. This content analysis identified and analyzed the story characteristics of 25 recently published and widely available picturebooks with mistake-related narratives. Findings include frequencies and descriptions of characters, plot, setting, and a host of other story attributes. Overall, messaging in these books was optimistic--emphasizing responsibility, growth, and acceptance--and making mistakes ultimately led to positive outcomes. Such stories are promising resources for the development of growth mindsets in young children. Teachers and caregivers can use these picturebooks to help children develop positive perceptions of mistakes and learn healthy ways to navigate them in their day-to-day lives.

Background: The MD Anderson Dysphagia Inventory (MDADI) is a widely used patient-reported outcome measure (PROM) which assesses dysphagia-related quality of life (QoL) in head and neck cancer (HNC). Despite its common use in HNC research and clinical practice, few of its psychometric properties have been reappraised since its inception. The aim of this study was to perform a survey-based qualitative analysis of UK HNC clinicians' perceptions of the content validity of the MDADI, evaluating it across the parameters of relevance, comprehensiveness and comprehensibility as per the COSMIN guideline for PROM assessment. Results: Four themes relating to the content validity of the MDADI were identified: (1) MDADI items lack clarity of definition of the terms 'swallowing', 'eating' and 'dysphagia'; (2) the MDADI is perceived to be overly negative in tone including items that service users may find distressing or disempowering; (3) items in the tool are exclusory to specific subgroups of patients, such as those who are nil by mouth or socially isolated; and (4) modifications to the MDADI were suggested and encouraged to make it more clinically useful and patient-centred. Conclusions: This study indicates that MDADI's content validity is 'insufficient' when rated by COSMIN parameters. This has significant implications for its continued use in HNC research and clinical practice. Further re-evaluation of the content validity of the MDADI is warranted, with potential future amendment of items being indicated if the results of this study are corroborated in subsequent research.

Background: Documented inequalities in access to eye care for people with learning disabilities and/or autism are caused by poor uptake of primary eye care services, poor identification of eye problems, lack of signposting and reasonable adjustments of existing services, concerns about costs of care and the low priority historically given to these issues in eye care policy at a regional and national level. In 2019, the charity SeeAbility employed four eye care champions (ECCs) with lived experience of learning disability and/or autism to work in local communities in London and the Northwest of England. They provided peer-to-peer support on understanding the need for good eye health and engaged with policy makers, and learning disability, autism and eye care professionals at the local, regional and national levels to influence both the clinical practice of individual practitioners (within existing service/pathway models) and more widely to influence the commissioning of the Easy Eye Care pathway. This study explores the experiences of these ECCs. Methods: The study was conducted in April and May 2023. A case study approach was used to describe the experiences of the ECCs from March 2019 to March 2023. Data from structured interviews with the four ECCs and workload analysis were triangulated to provide a multifaceted understanding of this novel health promotion project. Findings: The ECCs found the role useful and reported that confidence in their practice and impact grew with time but they required ongoing support in the role. A good understanding of the promotional messages was reported. Developing a good network of contacts at an early stage, both people with learning disabilities and healthcare professionals, was key. Relationships with professionals were supportive and positive and a positive emotive response to their lived experience was reported in these interactions. Conclusions: From the perspective of the ECCs, the role is useful and beneficial. The work suggests some key recommendations for future development which include planning to build networks, support in presentation and communications skills and defining key messages and knowledge. Confidence of the ECCs builds with time in the role but also needs support the emotive impact of their lived experiences on audiences is highlighted. There is a need to evaluate how the programme is perceived by those who interact with it and how it changes behaviours which leads to better health outcomes.

Since the discovery of fatty acid hydroxy fatty acids (FAHFAs), significant progress has been made in understanding their regulation, biochemistry, and physiological activities. Here, we contribute to this understanding by revealing that inflammation induces the production of fatty acid hydroxy stearic acids and fatty acid hydroxyoctadecadienoic acids in white adipose tissue depots and in adipocytes cocultured with macrophages. In lipopolysaccharide (LPS)-induced coculture systems, we confirm that adipose triglyceride lipase is required for inflammation-induced FAHFA generation and demonstrate that inflammation is necessary for producing hydroxy fatty acids. Chemically synthesized fatty acid hydroxyoctadecadienoic acids show anti-inflammatory activities in vivo, but only at supraphysiological concentrations. While endogenous FAHFAs are unlikely to be anti-inflammatory due to their low concentrations, conversion of proinflammatory hydroxy fatty acids into FAHFAs may dampen inflammation. Indeed, we demonstrate that proinflammatory lipids, such as hydroxyeicosatetraenoic acids (HETEs) and leukotriene B4 (LTB4), can be converted by cells in culture to weakly anti-inflammatory FAHFAs.

PURPOSE: The Audiovisual-Assisted Therapeutic Ambience in Radiotherapy (AVATAR) trial was a prospective multicenter study (NCT03991156) examining the combination of video immersion with radiation therapy and was successfully conducted through the collaboration of pediatric radiation oncology teams at 10 institutions independent of any pre-existing consortium. We sought to analyze and report the methodology of trial conception and development, process map, and cost. METHODS AND MATERIALS: The study enrolled patients aged 3 to 10 years preparing to undergo radiation therapy, integrated the combination of AVATAR-based video immersion with radiation therapy at each institution, and offered AVATAR use as an alternative to anesthesia, with rates of anesthesia use and outcomes of serial standardized anxiety and quality-of-life assessments assessed among the 81 children enrolled. A process map was created based on the trial timeline with the following components: study development time (time from conception of the trial to the accrual of the first patient, including design phase, agreement and approval phase, and site preparation phase), and accrual duration time (time from the first to last accrual). Costs and institutional success rates were calculated. RESULTS: Time from inception of study to last accrual was 3.6 years (1313 days). The study development time was 417 days (31.7%), and accrual duration time was 896 days (68.3%), with the final 50% of accrual occurring in

BACKGROUND: Artificial intelligence (AI) has transformative potential to support prehospital clinicians, emergency physicians, and trauma surgeons in acute traumatic injury care. This scoping review examines the literature evaluating AI models using prehospital features to support early traumatic injury care. METHODS: We conducted a systematic search in August 2023 of PubMed, Embase, and Web of Science. Two independent reviewers screened titles/abstracts, with a third reviewer for adjudication, followed by a full-text analysis. We included original research and conference presentations evaluating AI models-machine learning (ML), deep learning (DL), and natural language processing (NLP)-that used prehospital features or features available immediately upon emergency department arrival. Review articles were excluded. The same investigators extracted data and systematically categorized outcomes to ensure consistency and transparency. We calculated kappa for interrater reliability and descriptive statistics. RESULTS: We identified 1050 unique publications, with 49 meeting inclusion criteria after title and abstract review (kappa 0.58) and full-text review. Publications increased annually from 2 in 2007 to 10 in 2022. Geographic analysis revealed a 61% focus on data from the United States. Studies were predominantly retrospective (88%), used local (45%) or national level (41%) data, focused on adults only (59%) or did not specify adults or pediatrics (27%), and 57% encompassed both blunt and penetrating injury mechanisms. The majority used machine learning (88%) alone or in conjunction with DL or NLP, and the top three algorithms used were support vector machine, logistic regression, and random forest. The most common study objectives were to predict the need for critical care and life-saving interventions (29%), assist in triage (22%), and predict survival (20%). CONCLUSIONS: A small but growing body of literature described AI models based on prehospital features that may support decisions made by dispatchers, Emergency Medical Services clinicians, and trauma teams in early traumatic injury care.

PURPOSE: Optical development of the zebrafish eye relies on the movement of the highly refractive lens nucleus from an anterior to a central location in the optical axis during development. We have shown that this mechanism in turn depends on the function of Aquaporin 0a (Aqp0a), a multifunctional and extremely abundant protein in lens fiber cell membranes. Here, we probe the specific cellular functions necessary for rescuing lens nucleus centralization defects in aqp0a-/- null mutants by stable overexpression of an Aqp0 orthologue from a killifish, MIPfun. METHODS: We test in vivo requirements for lens transparency and nucleus centralization of MIPfun for auto-adhesion, water permeability (Pf), and Pf sensitivity to regulation by Ca2+ or pH by overexpression of MIPfun mutants previously shown to have defects in these functions in vitro or in silico. RESULTS: Water permeability of MIPfun is essential for rescuing lens transparency and nucleus centralization defects, whereas auto-adhesion is not. Furthermore, water permeability regulation by Ca2+ and pH appear residue-dependent, because some Ca2+-insensitive mutants fail to rescue, and pH-insensitive mutants only partially rescue defects. MIPfun lacking Pf sensitivity to both, Ca2+ and pH, also fails to rescue lens nucleus centralization. CONCLUSION: This study shows that regulation of water permeability by Aqp0 plays a key role in the centralization of the zebrafish lens nucleus, providing the first direct evidence for water transport in this aspect of optical development.

Present and future climatic trends are expected to markedly alter water fluxes and stores in the hydrologic cycle. In addition, water demand continues to grow due to increased human use and a growing population. Sustainably managing water resources requires a thorough understanding of water storage and flow in natural, agricultural, and urban ecosystems. Measurements of stable isotopes of water (hydrogen and oxygen) in the water cycle (atmosphere, soils, plants, surface water, and groundwater) can provide information on the transport pathways, sourcing, dynamics, ages, and storage pools of water that is difficult to obtain with other techniques. However, the potential of these techniques for practical questions has not been fully exploited yet. Here, we outline the benefits and limitations of potential applications of stable isotope methods useful to water managers, farmers, and other stakeholders. We also describe several case studies demonstrating how stable isotopes of water can support water management decision-making. Finally, we propose a workflow that guides users through a sequence of decisions required to apply stable isotope methods to examples of water management issues. We call for ongoing dialogue and a stronger connection between water management stakeholders and water stable isotope practitioners to identify the most pressing issues and develop best-practice guidelines to apply these techniques.

Abstract: Quantifying evapotranspiration (ET) is critical to accurately predict vegetation health, groundwater recharge, and streamflow generation. Hillslope aspect, the direction a hillslope faces, results in variable incoming solar radiation and subsequent vegetation water use that drive ET. Previous work in watersheds with a single dominant vegetation type (e.g., trees) have shown that equator‐facing slopes (EFS) have higher ET compared to pole‐facing slopes (PFS) due to higher evaporative demand. However, it remains unclear how differences in vegetation type (i.e., grasses and trees) influence ET and water partitioning between hillslopes with opposing aspects. Here, we quantified ET and root‐zone water storage deficits between a PFS and EFS with contrasting vegetation types within central coastal California. Our results suggest that the cooler PFS with oak trees has higher ET than the warmer EFS with grasses, which is counter to previous work in landscapes with a singule dominant vegetation type. Our root‐zone water storage deficit calculations indicate that the PFS has a higher subsurface storage deficit and a larger seasonal dry down than the EFS. This aspect difference in subsurface water storage deficits may influence the subsequent replenishment of dynamic water storage, groundwater recharge and streamflow generation. In addition, larger subsurface water deficits on PFS may reduce their ability to serve as hydrologic refugia for oaks during multi‐year droughts. This research provides a novel integration of field‐based and remotely‐sensed estimates of ET required to properly quantify hillslope‐scale water balances. These findings emphasize the importance of resolving hillslope‐scale vegetation structure within Earth system models, especially in landscapes with diverse vegetation types.

The impostor phenomenon is a psychological construct referring to a range of negative emotions associated with a person's perception of their own "fraudulent competence" in a field or of their lack of skills necessary to be successful in that field. Anecdotal evidence suggests that many practicing evaluators have experienced impostor feelings, but lack a framework in which to understand their experiences and the forums in which to discuss them. This paper summarizes the literature on the impostor phenomenon, applies it to the field of evaluation, and describes the results of an empirical, quantitatively focused study which included open-ended qualitative questions exploring impostorism in 323 practicing evaluators. The results suggest that impostor phenomenon in evaluators consists of three constructs: Discount, Luck, and Fake. Qualitative data analysis suggests differential coping strategies for men and women. Thematic analysis guided the development of a set of proposed solutions to help lessen the phenomenon's detrimental effects for evaluators.

While transition from primary to secondary school is a positive experience for many young people, for others, it may be a difficult period of adjustment. Socioeconomic status (SES) may influence the likelihood of a positive or negative transition experience owing to differences in psychosocial (self-esteem, self-efficacy, social support) and flexible (cultural capital, financial support, power) resources to respond to the challenges presented by a new school environment. Welsh all-age schools do not have a typical primary to secondary school transition and offer an opportunity for comparative analysis to explore the impact of transition on young people. This analysis used multilevel and structural equation modelling to assess differences in mental health and bullying outcomes in year 7 (first year of secondary education) in young people in all-age schools compared with those in secondary schools. It also considered whether school connectedness might explain these differences. It found that school type did not significantly predict outcomes at a population level; however, there was evidence of an interaction between SES and school attended for some outcomes. Peer problems, conduct problems and bullying victimisation were lower for children with low SES when attending all-age schools. For children with high SES, the same outcomes tended to be more positive if the children attended secondary schools. There was no evidence that school connectedness mediated the relationship between school type and mental health or bullying outcomes. Findings provide tentative evidence that all-age schools may act to reduce health inequalities caused by SES.

Fixel-based analysis was used to probe age-related changes in white matter micro- and macrostructure of the corpus callosum between participants with (N = 54) and without (N = 50) autism spectrum disorder (ASD). Data were obtained from the Autism Brain Imaging Data Exchange-II (ABIDE-II). Compared to age-matched controls, young adolescents with ASD (11.19 ± 7.54 years) showed reduced macroscopic fiber cross-section (logFC) and combined fiber-density and cross-section (FDC). Reduced fiber-density (FD) and FDC was noted in a marginally older (13.87 ± 3.15 years) ASD cohort. Among the oldest ASD cohort (17.07 ± 3.56 years), a non-significant trend indicative of reduced FD was noted. White matter aberration appears greatest and most widespread among younger ASD cohorts. This supports the suggestion that some early neuropathophysiological indicators in ASD may dissipate with age.

Background: People with a learning disability experience challenges accessing primary health care services, including eye care services. Methods: Eye care needs of people with a learning disability, and how well they are met by existing services in England, were explored. Barriers and enablers to accessing these services were investigated. This was informed by a scoping review of the literature and a historic literature library. Findings: Adults with a learning disability are 10 times more likely than other adults to have a serious sight problem and children with learning disabilities are 28 times more likely. There is good evidence of high levels of unmet eye care need special schools in England with over 4 in 10 children attending having no history of any eye care. Conclusion: The authors discuss possible systemic changes to address these inequalities in England. These include automatic entitlement to an NHS sight test annually, specialist pathways in community opticians, eye care services in special schools, and peer to peer and peer to professional promotion of services by people with lived experience. Dedicated care pathways have improved uptake of services in other areas of primary care. Research into the effectiveness of lived experience eye health advocacy is needed.

Anxiety is a multifaceted force that can negatively impact the ability of evaluators to succeed in practice. In the evaluation literature, discussions concerning anxiety have primarily been limited to strategies to reduce stakeholder anxiety to encourage positive and productive working relationships with evaluators. This study was among the first to explicitly recognize and empirically assess the anxiety "evaluators" feel during practice. Using a mixed-methods design, a random sample of 109 American Evaluation Association members was surveyed. There was overwhelming agreement (96.30%) that evaluator anxiety is a commonly experienced phenomenon, often citing reasons such as lack of experience, imposter syndrome, unreasonable scope, and difficulties with stakeholder interactions as key contributors to increased anxiety. Evaluator anxiety varied across stages of the evaluation process, with some stages eliciting more anxiety than others. Further discussion and training concerning how to reduce evaluator anxiety could be useful in the preparation of evaluators.

In her book Folklore of the Disc Jacqueline Simpson argues persuasively that 'Whatever is folklore on Earth finds its mirror in the reality of the disc' (14). Following her, I propose that a study of recurring images, motifs and allusions in the Tiffany books suggests that Tiffany might be considered the Discworld's reflection of Earth's Celtic Sovereignty Goddess. For anyone who has read the Witches books, even a superficial consideration of this statement rings true, given that the Celtic Sovereignty Goddesses were bound to the land and were responsible for everything in their territories, from birth and death and the welfare of livestock to guarding the boundaries against intruders and endorsing the rule of the mortal king. Just so, Pratchett's witches are bound to the land of their steadings and care for everything that lives there. They are midwives and they tend to the dying. They also guard the borders of their homes and have the authority to ratify or rescind the legitimacy of those who rule. In this article, I therefore propose that as a young Tiffany Aching feels out the shape of her power, learning from the older witches and stepping into her responsibilities, Pratchett takes this opportunity to reflect on the mythical and folkloric force that shapes her and, arguably all his witches, and I contend that this force is the Celtic Sovereignty Goddess. Additional Keywords Tiffany Aching; Celtic Sovereignty Goddess; Celtic mythology; Terry Pratchett, Recommended Citation Eileen Donaldson University of South Africa Rec-240816-052 THERE ARE MANY REASONS WHY TERRY PRATCHETT'S BOOKS are so widely loved, certainly too many--both subjective and objective--to enumerate them here. [...]