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1. An Overview of the Management of Drug-Resistant Tuberculosis in Six French-Speaking African Countries from 2018 to 2022

Author: Gisèle Badoum, Abdoul R. Ouédraogo, Attannon A. Fiogbé, Albert Kuate Kuate, Alphazazi Soumana, Yacine Mar Diop, Mohammed F. Dogo, Olivia B. Mbitikon, Adjima Combary, Gildas Agodokpessi, Dissou Affolabi, Annie Bisso, Dona R. Atimbada, Sonia Menon, and Kobto G. Koura
Subjects: drug-resistant tuberculosis, treatment outcomes, French-speaking African countries, Medicine
Abstract: Drug-resistant tuberculosis (DR-TB) poses a significant public health challenge, particularly in resource-limited settings. The prevalence and management of DR-TB in African countries require comprehensive strategies to improve patient outcomes and control the spread of the disease. Aggregated routine data (from 2018 to 2022) on multidrug-resistant TB (MDR-TB) were collected from the National TB Programs (NTPs) from all six countries. The diagnostic capacity for MDR-TB was globally insufficient. The system for collecting and transporting samples was sometimes inoperative. A total of 2353 cases of MDR-TB were reported, with 86.4% receiving treatment. The gap between the expected number of MDR-TB cases and the number reported per country varied from 51.5% to 88.0%, depending on the year. Fifty-two extensively drug-resistant (XDR) TB cases received treatment regimens over five years, with variations across countries. All patients received free follow-up examinations, nutritional and financial support for travel expenses to the outpatient care and treatment centers. The MDR-TB treatment success rates for all regimens between 2018 and 2021 ranged from 44.4 to 90.9%, varying by country and year. The information system relied on primary tools, reporting tools, and digital solutions. Progress has been made in MDR-TB management; however, challenges persist, necessitating resources to enhance access to rapid molecular screening tests.
Published: 2024
Full Text: View/download PDF

2. Deep-sea deployment of the KM3NeT neutrino telescope detection units by self-unrolling

Author: The KM3NeT Collaboration, Aiello, S., Albert, A., Garre, S. Alves, Aly, Z., Ameli, F., Anassontzis, E. G., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Anton, G., Ardid, M., Aublin, J., Bagatelas, C., Bakker, R., Barbarino, G., Baret, B., Pree, S. Basegmez du, Bendahman, M., Berbeen, E., Berg, A. M. van den, Bertin, V., Biagi, S., Billault, M., Bissinger, M., Boettcher, M., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caiffi, B., Caillat, L., Calvo, D., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Colonges, S., Coniglione, R., Corredoira, I., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Onofrio, A., Dallier, R., De Palma, M., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donà, R., Donzau, C., Dornic, D., Dörr, M., Drouhin, D., Eberl, T., Eddyamoui, A., van Eeden, T., van Eijk, D., Bojaddaini, I. El, Elsaesser, D., Enzenhöfer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipović, M. D., Filippini, F., Fusco, L. A., Gabella, O., Gal, T., Soto, A. Garcia, Garufi, F., Gatelet, Y., Geißelbrecht, N., Gialanella, L., Giorgio, E., Gostiaux, L., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Grella, G., Grmek, A., Guderian, D., Guidii, C., Hallmann, S., Hamdaoui, H., van Haren, H., van Heerwaarden, J., Heijboer, A., Hekaloa, A., Henry, S., Hernández-Rey, J. J., Hillebrand, T., Hofestädt, J., Huang, F., Ibnsalih, W. Idrissi, Ilioni, A., Illuminati, G., James, C. W., de Jong, M., de Jong, P., Jung, B. J., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, Kistauri, G., van der Knaap, F., Koffeman, E. N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Laan, M., Lahmann, R., Lamare, P., Larosa, G., Laurence, J., Breton, R. Le, Leonardi, O., Leone, F., Leonora, E., Levi, G., Lincetto, M., Clark, M. Lindsey, Lipreau, T., Longhitano, F., LopezCotoa, D., Maderer, L., Mańczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Mazzou, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Morganti, M., Moser, M., Moussa, A., Muller, R., Pérez, D. Muñoz, Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Fearraigh, B. Ó, O'Sullivan, M., Organokov, M., Orlando, A., González, J. Palacios, Papalashvili, G., Papaleo, R., Pastore, C., Păun, A. M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Pikounis, K., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Pühlhofer, G., Pulvirenti, S., Rabyang, O., Raffaelli, F., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Richer, M., Rivoire, S., Rovelli, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schnabel, J., Schumann, J., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Taiutii, M., Tayalati, Y., Tenllado, E., Tézier, D., Thakore, T., Tingay, S., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: KM3NeT is a research infrastructure being installed in the deep Mediterranean Sea. It will house a neutrino telescope comprising hundreds of networked moorings - detection units or strings equipped with optical instrumentation to detect the Cherenkov radiation generated by charged particles from neutrino-induced collisions in its vicinity. In comparison to moorings typically used for oceanography, several key features of the KM3NeT string are different: the instrumentation is contained in transparent and thus unprotected glass spheres; two thin Dyneema ropes are used as strength members; and a thin delicate backbone tube with fibre-optics and copper wires for data and power transmission, respectively, runs along the full length of the mooring. Also, compared to other neutrino telescopes such as ANTARES in the Mediterranean Sea and GVD in Lake Baikal, the KM3NeT strings are more slender to minimise the amount of material used for support of the optical sensors. Moreover, the rate of deploying a large number of strings in a period of a few years is unprecedented. For all these reasons, for the installation of the KM3NeT strings, a custom-made, fast deployment method was designed. Despite the length of several hundreds of metres, the slim design of the string allows it to be compacted into a small, re-usable spherical launching vehicle instead of deploying the mooring weight down from a surface vessel. After being lowered to the seafloor, the string unfurls to its full length with the buoyant launching vehicle rolling along the two ropes.The design of the vehicle, the loading with a string, and its underwater self-unrolling are detailed in this paper.
Published: 2020

3. The Control Unit of the KM3NeT Data Acquisition System

Author: Aiello, S., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Aublin, J., Bagatelas, C., Barbarino, G., Baret, B., Pree, S. Basegmez du, Bendahman, M., Berbee, E., Berg, A. M. van den, Bertin, V., Biagi, S., Biagioni, A., Bissinger, M., Boumaaza, J., Bourret, S., Bouta, M., Bouvet, G., Bouwhuis, M., Bozza, C., Branzas, H., Bruchner, M., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Calvo, D., Capone, A., Celli, S., Chabab, M., Chau, N., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., D'Onofrio, A., Dallier, R., De Palma, M., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donà, R., Donzaud, C., Dornic, D., Dörr, M., Durocher, M., Eberl, T., Bojaddaini, I. El, Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Fermani, P., Ferrara, G., Filipovic, M. D., Franco, A., Fusco, L. A., Gal, T., Soto, A. Garcia, Garufi, F., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Grégoire, T., Grella, G., Guderian, D., Guidi, C., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Illuminati, G., James, C. W., de Jong, M., de Jong, P., Kadler, M., Kalaczynski, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, van der Knaap, F., Koffeman, E. N., Kooijman, P., Kouchner, A., Kulikovskiy, V., Lahmann, R., Larosa, G., Breton, R. Le, Leone, F., Leonora, E., Levi, G., Lincetto, M., Lonardo, A., Longhitano, F., Lopez-Coto, D., Maggi, G., Manczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martignac, G., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mazzou, S., Mele, R., Melis, K. W., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nielsen, C., Fearraigh, B. O', Organokov, M., Orlando, A., Panagopoulos, V., Papalashvili, G., Papaleo, R., Pastore, C., Pavalas, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Pikounis, K., Pisanti, O., Poirè, C., Polydefki, G., Popa, V., Post, M., Pradier, T., Puhlhofer, G., Pulvirenti, S., Quinn, L., Raffaelli, F., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Reubelt, J., Riccobene, G., Richer, M., Rigalleau, L., Rovelli, A., Salvadori, I., Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schnabel, J., Sciacca, V., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Strandberg, B., Stransky, D., Taiuti, M., Tayalati, Y., Tenllado, E., Thakore, T., Tingay, S., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Vannoye, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczynski, R., de Wolf, E., Zaborov, D., Zegarelli, A., Zornoza, J. D., and Zúñiga, J.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: The KM3NeT Collaboration runs a multi-site neutrino observatory in the Mediterranean Sea. Water Cherenkov particle detectors, deep in the sea and far off the coasts of France and Italy, are already taking data while incremental construction progresses. Data Acquisition Control software is operating off-shore detectors as well as testing and qualification stations for their components. The software, named Control Unit, is highly modular. It can undergo upgrades and reconfiguration with the acquisition running. Interplay with the central database of the Collaboration is obtained in a way that allows for data taking even if Internet links fail. In order to simplify the management of computing resources in the long term, and to cope with possible hardware failures of one or more computers, the KM3NeT Control Unit software features a custom dynamic resource provisioning and failover technology, which is especially important for ensuring continuity in case of rare transient events in multi-messenger astronomy. The software architecture relies on ubiquitous tools and broadly adopted technologies and has been successfully tested on several operating systems.
Published: 2019
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4. On the Relationship between Traffic Hysteresis and String Stability of Vehicle Platoons

Author: Mattas, K., Albano, G., Donà, R., He, Y., and Ciuffo, B.
Published: 2023
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5. KM3NeT front-end and readout electronics system: hardware, firmware and software

Author: The KM3NeT Collaboration, Aiello, S., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Aublin, J., Bagatelas, C., Barbarino, G., Baret, B., Pree, S. Basegmez du, Belias, A., Berbee, E., Berg, A. M. van den, Bertin, V., van Beveren, V., Biagi, S., Biagioni, A., Bianucci, S., Billault, M., Bissinger, M., Bos, P., Boumaaza, J., Bourret, S., Bouta, M., Bouvet, G., Bouwhuis, M., Bozza, C., Brânzaş, H., Briel, M., Bruchner, M., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Calvo, D., Capone, A., Celli, S., Chabab, M., Chau, N., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, B., Coleiro, A., Molla, M. Colomer, Colonges, S., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., D'Onofrio, A., Dallier, R., De Palma, M., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donà, R., Donzaud, C., Dornic, D., Dörr, M., Durocher, M., Eberl, T., van Eeden, T., Bojaddaini, I. El, Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Fermani, P., Ferrara, G., Filipović, M. D., Fusco, L. A., Gajanana, D., Gal, T., Soto, A. Garcia, Garufi, F., Gialanella, L., Giorgio, E., Giuliante, A., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Grégoire, T., Grella, G., Guderian, D., Guidi, C., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Santiago, E. Huesca, Illuminati, G., James, C. W., Jansweijer, P., Jongen, M., de Jong, M., de Jong, P., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, van der Knaap, F., Koffeman, E. N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., K., Meghna K., Lahmann, R., Larosa, G., Breton, R. Le, Leone, F., Leonora, E., Levi, G., Lincetto, M., Lonardo, A., Longhitano, F., Lopez-Coto, D., Maggi, G., Mańczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martignac, G., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mazzou, S., Mele, R., Melis, K. W., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musico, P., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nielsen, C., Fearraigh, B. Ó, Organokov, M., Orlando, A., Panagopoulos, V., Papalashvili, G., Papaleo, R., Pastore, C., Păvălaş, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pikounis, K., Pisanti, O., Poirè, C., Polydefki, G., Popa, V., Post, M., Pradier, T., Pühlhofer, G., Pulvirenti, S., Quinn, L., Raffaelli, F., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Reubelt, J., Riccobene, G., Richer, M., Rigalleau, L., Rovelli, A., Salvadori, I., Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schmelling, J., Schnabel, J., Sciacca, V., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Strandberg, B., Stransky, D., Taiuti, M., Tayalati, Y., Tenllado, E., Thakore, T., Timmer, P., Tingay, S., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Zaborov, D., Zegarelli, A., Zornoza, J. D., and Zúñiga, J.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The KM3NeT research infrastructure being built at the bottom of the Mediterranean Sea will host water-Cherenkov telescopes for the detection of cosmic neutrinos. The neutrino telescopes will consist of large volume three-dimensional grids of optical modules to detect the Cherenkov light from charged particles produced by neutrino-induced interactions. Each optical module houses 31 3-inch photomultiplier tubes, instrumentation for calibration of the photomultiplier signal and positioning of the optical module and all associated electronics boards. By design, the total electrical power consumption of an optical module has been capped at seven watts. This paper presents an overview of the front-end and readout electronics system inside the optical module, which has been designed for a 1~ns synchronization between the clocks of all optical modules in the grid during a life time of at least 20 years., Comment: Prepared submission to Journal of Astronomical Telescopes, Instruments, and Systems (JATIS)
Published: 2019

6. Dependence of atmospheric muon flux on seawater depth measured with the first KM3NeT detection units

Author: KM3NeT Collaboration, Ageron, M., Aiello, S., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Aublin, J., Bagatelas, C., Barbarino, G., Baret, B., Pree, S. Basegmez du, Belias, A., Berbee, E., Berg, A. M. van den, Bertin, V., van Beveren, V., Biagi, S., Biagioni, A., Bianucci, S., Billault, M., Bissinger, M., de Boer, R., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Briel, M., Bruchner, M., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caillat, L., Calì, C., Calvo, D., Capone, A., Celli, S., Chabab, M., Chau, N., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Colonges, S., Coniglione, R., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., D'Onofrio, A., Dallier, R., De Palma, M., De Sio, C., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donà, R., Donzaud, C., van Dooren, L., Dornic, D., Dörr, M., Durocher, M., Eberl, T., van Eeden, T., Bojaddaini, I. El, Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Fermani, P., Ferrara, G., Filipović, M. D., Fusco, L. A., Gajanana, D., Gal, T., Soto, A. Garcia, Garufi, F., Gialanella, L., Giorgio, E., Giuliante, A., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Grégoire, T., Grella, G., Grimaldi, A., Grmek, A., Guderian, D., Guerzoni, M., Guidi, C., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Henry, S., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Santiago, E. Huesca, Illuminati, G., James, C. W., Jansweijer, P., Jongen, M., de Jong, M., de Jong, P., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U. F., Kayzel, F., Keller, P., Chowdhury, N. R. Khan, van der Knaap, F., Koffeman, E. N., Kooijman, P., Koopstra, J., Kouchner, A., Kreter, M., Kulikovskiy, V., K., Meghna K., Lahmann, R., Lamare, P., Larosa, G., Laurence, J., Breton, R. Le, Leone, F., Leonora, E., Levi, G., Librizzi, F., Lincetto, M., Litrico, P., Alvarez, C. D. Llorens, Lonardo, A., Longhitano, F., Lopez-Coto, D., Maggi, G., Mańczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mele, R., Melis, K. W., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musico, P., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nielsen, C., Fearraigh, B. Ó, Organokov, M., Orlando, A., Panagopoulos, V., Pancaldi, G., Papalashvili, G., Papaleo, R., Pastore, C., Păvălaş, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pikounis, K., Pisanti, O., Poirè, C., Polydefki, G., Popa, V., Post, M., Pradier, T., Pühlhofer, G., Pulvirenti, S., Quinn, L., Raffaelli, F., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Reubelt, J., Riccobene, G., Rigalleau, L., Rizza, G., Rocco, R., Rovelli, A., Royon, J., Salemi, M., Salvadori, I., Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schmelling, J., Sciacca, V., Sciliberto, D., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Strandberg, B., Stransky, D., Stüven, T., Taiuti, M., Tayalati, Y., Tenllado, E., Tézier, D., Thakore, T., Theraube, S., Timmer, P., Tingay, S., Trovato, A., Tsagkli, S., Tzamariudaki, E., Tzanetatos, D., Valieri, C., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Zaborov, D., Zegarelli, A., Zornoza, J. D., and Zúñiga, J.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: KM3NeT is a research infrastructure located in the Mediterranean Sea, that will consist of two deep-sea Cherenkov neutrino detectors. With one detector (ARCA), the KM3NeT Collaboration aims at identifying and studying TeV-PeV astrophysical neutrino sources. With the other detector (ORCA), the neutrino mass ordering will be determined by studying GeV-scale atmospheric neutrino oscillations. The first KM3NeT detection units were deployed at the Italian and French sites between 2015 and 2017. In this paper, a description of the detector is presented, together with a summary of the procedures used to calibrate the detector in-situ. Finally, the measurement of the atmospheric muon flux between 2232-3386 m seawater depth is obtained., Comment: 15 pages, 9 figures
Published: 2019
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7. A Search for Cosmic Neutrino and Gamma-Ray Emitting Transients in 7.3 Years of ANTARES and Fermi LAT Data

Author: Solares, H. A. Ayala, Cowen, D. F., DeLaunay, J. J., Fox, D. B., Keivani, A., Mostafá, M., Murase, K., Turley, C. F., Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Barrios-Martı, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Moursli, R. Cherkaoui El, Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Dı'az, A. F., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donà, R., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. El, Khayati, N. El, Elsässer, D., Enzenhöfer, A., Ettahiri, A., Fassi, F., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Grégoire, T., Ruiz, R. Gracia, Graf, K., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Illuminati, G., James, C. W., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Breton, R. Le, Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Lotze, M., Loucatos, S., Maggi, G., Marcelin, M., Margiotta, A., Marinelli, A., Martınez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nielsen, C., Nuñez, A., Organokov, M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sánchez-Losa, A., Salah-Eddine, A., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Thakore, T., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., and Zúñiga, J.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We analyze 7.3 years of ANTARES high-energy neutrino and Fermi LAT {\gamma}-ray data in search of cosmic neutrino + {\gamma}-ray ({\nu}+{\gamma}) transient sources or source populations. Our analysis has the potential to detect either individual {\nu}+{\gamma} transient sources (durations {\delta}t < 1000~s), if they exhibit sufficient {\gamma}-ray or neutrino multiplicity, or a statistical excess of {\nu}+{\gamma} transients of lower multiplicities. Treating ANTARES track and cascade event types separately, we establish detection thresholds by Monte Carlo scrambling of the neutrino data, and determine our analysis sensitivity by signal injection against scrambled datasets. We find our analysis is sensitive to {\nu}+{\gamma} transient populations responsible for $>$5\% of the observed gamma-coincident neutrinos in the track data at 90\% confidence. Applying our analysis to the unscrambled data reveals no individual {\nu}+{\gamma} events of high significance; two ANTARES track + Fermi {\gamma}-ray events are identified that exceed a once per decade false alarm rate threshold ($p=17\%$). No evidence for subthreshold {\nu}+{\gamma} source populations is found among the track ($p=39\%$) or cascade ($p=60\%$) events. While TXS 0506+056, a blazar and variable (non-transient) Fermi {\gamma}-ray source, has recently been identified as the first source of high-energy neutrinos, the challenges in reconciling observations of the Fermi {\gamma}-ray sky, the IceCube high-energy cosmic neutrinos, and ultra-high energy cosmic rays using only blazars suggest a significant contribution by other source populations. Searches for transient sources of high-energy neutrinos remain interesting, with the potential for neutrino clustering or multimessenger coincidence searches to lead to discovery of the first {\nu}+{\gamma} transients., Comment: 11 pages, 5 figures, 2 tables
Published: 2019
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8. ANTARES neutrino search for time and space correlations with IceCube high-energy neutrino events

Author: ANTARES Collaboration, Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Baret, B., Barrios-Martí, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Moursli, R. Cherkaoui El, Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Díaz, A. F., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donà, R., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. El, yati, N. El Kha, Elsässer, D., Enzenhöfer, A., tahiri, A. E, Fassi, F., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Grégoire, T., Ruiz, R. Gracia, Graf, K., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Illuminati, G., James, C. W., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Breton, R. Le, Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Lotze, M., Loucatos, S., Maggi, G., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nielsen, C., Nuñez, A., Organokov, M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sánchez-Losa, A., Salah-Eddine, A., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Thakore, T., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., and Zúñiga, J.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: In the past years, the IceCube Collaboration has reported in several analyses the observation of astrophysical high-energy neutrino events. Despite a compelling evidence for the first identification of a neutrino source, TXS 0506+056, the origin of the majority of these events is still unknown. In this paper, a possible transient origin of the IceCube astrophysical events is searched for using neutrino events detected by the ANTARES telescope. The arrival time and direction of 6894 track-like and 160 shower-like events detected over 2346 days of livetime are examined to search for coincidences with 54 IceCube high-energy track-like neutrino events, by means of a maximum likelihood method. No significant correlation is observed and upper limits on the one-flavour neutrino fluence from the direction of the IceCube candidates are derived. The non-observation of time and space correlation within the time window of 0.1 days with the two most energetic IceCube events constrains the spectral index of a possible point-like transient neutrino source, to be harder than $-2.3$ and $-2.4$ for each event, respectively., Comment: 14 pages, 5 figures
Published: 2019
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9. Measuring the atmospheric neutrino oscillation parameters and constraining the 3+1 neutrino model with ten years of ANTARES data

Author: ANTARES Collaboration, Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Avgitas, T., Baret, B., Barrios-Martí, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Moursli, R. Cherkaoui El, Chiarusi, T., Circella, M., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Díaz, A. F., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donà, R., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. El, Khayati, N. El, Elsässer, D., Enzenhöfer, A., Ettahiri, A., Fassi, F., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Gozzini, R., Grégoire, T., Ruiz, R. Gracia, Graf, K., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Illuminati, G., James, C. W., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Lahmann, R., Breton, R. Le, Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lotze, M., Loucatos, S., Maggi, G., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nielsen, C., Nuñez, A., Organokov, M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sánchez-Losa, A., Salah-Eddine, A., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Thakore, T., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., and Zúñiga, J.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: The ANTARES neutrino telescope has an energy threshold of a few tens of GeV. This allows to study the phenomenon of atmospheric muon neutrino disappearance due to neutrino oscillations. In a similar way, constraints on the 3+1 neutrino model, which foresees the existence of one sterile neutrino, can be inferred. Using data collected by the ANTARES neutrino telescope from 2007 to 2016, a new measurement of $\Delta m^2_{32}$ and $\theta_{23}$ has been performed - which is consistent with world best-fit values - and constraints on the 3+1 neutrino model have been derived.
Published: 2018

10. Search for Multi-messenger Sources of Gravitational Waves and High-energy Neutrinos with Advanced LIGO during its first Observing Run, ANTARES and IceCube

Author: ANTARES, IceCube, LIGO, Collaborations, Virgo, Albert, A., Andre, M., Anghinolfi, M., Ardid, M., Aubert, J. -J., Aublin, J., Avgitas, T., Baret, B., Barrios-Marti, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouwhuis, M. C., Brânzas, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., Moursli, R. Cherkaoui El, Chiarusi, T., Circella, M., Coelho, J. A. B., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Diaz, A. F., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Dona, R., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. El, Khayati, N. El, Elsasser, D., Enzenhofer, A., Ettahiri, A., Fassi, F., Felis, I., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Gregoire, T., Ruiz, R. Gracia, Graf, K., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernandez-Rey, J. J., Hol, J., Hofestadt, J., Illuminati, G., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Lahmann, R., Lefevre, D., Leonora, E., Levi, G., Lotze, M., Loucatos, S., Maggi, G., Marcelin, M., Margiotta, A., Marinelli, A., Martinez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nunez, A., Organokov, M., Pavalas, G. E., Pellegrino, C., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sanchez-Losa, A., Saldana, M., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schussler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., Zuniga, J., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Arguelles, C., Auffenberg, J., Axani, S., Backes, P., Bagherpour, H., Bai, X., Barbano, A., Barron, J. P., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Borner, M., Bos, F., Boser, S., Botner, O., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Brenzke, M., Bretz, H. -P., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Carver, T., Cheung, E., Chirkin, D., Clark, K., Classen, L., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., Day, M., de Andre, J. P. A. M., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Diaz-Velez, J. C., di Lorenzo, V., Dujmovic, H., Dumm, J. 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R., Koirala, R., Kolanoski, H., Kopke, L., Kopper, C., Kopper, S., Koschinsky, J. P., Koskinen, D. J., Kowalski, M., Krings, K., Kroll, M., Kruckl, G., Kunwar, S., Kurahashi, N., Kyriacou, A., Labare, M., Lanfranchi, J. L., Larson, M. J., Lauber, F., Leonard, K., Leuermann, M., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lunemann, J., Luszczak, W., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Maris, I. C., Maruyama, R., Mase, K., Maunu, R., Meagher, K., Medici, M., Meier, M., Menne, T., Merino, G., Meures, T., Miarecki, S., Micallef, J., Momente, G., Montaruli, T., Moore, R. W., Moulai, M., Nagai, R., Nahnhauer, R., Nakarmi, P., Naumann, U., Neer, G., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Peiffer, P., Pepper, J. A., Heros, C. Perez de los, Pieloth, D., Pinat, E., Pizzuto, A., Plum, M., Price, P. B., Przybylski, G. T., Raab, C., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Reimann, R., Relethford, B., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schoneberg, S., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stasik, A., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stol, A., Strotjohann, N. L., Stuttard, T., Sullivan, G. W., Sutherland, M., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Toale, P. A., Tobin, M. N., Tonnis, C., Toscano, S., Tosi, D., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. 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G., Ascenzi, S., Ashton, G., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., AultONeal, K., Austin, C., Avendano, V., Avila-Alvarez, A., Babak, S., Bacon, P., Badaracco, F., Bader, M. K. M., Bae, S., Baker, P. T., Baldaccini, F., Ballardin, G., Ballmer, S. W., Banagiri, S., Barayoga, J. C., Barclay, S. E., Barish, B. C., Barker, D., Barkett, K., Barnum, S., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Bazzan, M., Becsy, B., Bejger, M., Belahcene, I., Bell, A. S., Beniwal, D., Berger, B. K., Bergmann, G., Bernuzzi, S., Bero, J. J., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bidler, J., Bilenko, I. A., Bilgili, S. A., Billingsley, G., Birch, J., Birney, R., Birnholtz, O., Biscans, S., Biscoveanu, S., Bisht, A., Bitossi, M., Bizouard, M. A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. 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T., Meacher, D., Meadors, G. D., Mehmet, M., Mehta, A. K., Meidam, J., Melatos, A., Mendell, G., Mercer, R. A., Mereni, L., Merilh, E. L., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Metzdorff, R., Meyers, P. M., Miao, H., Michel, C., Middleton, H., Mikhailov, E. E., Milano, L., Miller, A. L., Miller, A., Millhouse, M., Mills, J. C., Milovich-Goff, M. C., Minazzoli, O., Minenkov, Y., Mishkin, A., Mishra, C., Mistry, T., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Mo, G., Moffa, D., Mogushi, K., Mohapatra, S. R. P., Montani, M., Moore, C. J., Moraru, D., Moreno, G., Morisaki, S., Mours, B., Mow-Lowry, C. M., Mukherjee, Arunava, Mukherjee, D., Mukherjee, S., Mukund, N., Mullavey, A., Munch, J., Muniz, E. A., Muratore, M., Murray, P. G., Nardecchia, I., Naticchioni, L., Nayak, R. K., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neunzert, A., Ng, K. Y., Ng, S., Nguyen, P., Nichols, D., Nissanke, S., Nocera, F., North, C., Nuttall, L. 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E., Sanchis-Gual, N., Sandberg, V., Sanders, J. R., Santiago, K. A., Sarin, N., Sassolas, B., Saulson, P. R., Sauter, O., Savage, R. L., Schale, P., Scheel, M., Scheuer, J., Schiettekatte, F., Schmidt, P., Schnabel, R., Schofield, R. M. S., Schonbeck, A., Schreiber, E., Schulte, B. W., Schutz, B. F., Schwalbe, S. G., Scott, J., Scott, S. M., Seidel, E., Sellers, D., Sengupta, A. S., Sennett, N., Sentenac, D., Sequino, V., Sergeev, A., Setyawati, Y., Shaddock, D. A., Shaffer, T., Shahriar, M. S., Shaner, M. B., Shao, L., Sharma, P., Shawhan, P., Shen, H., Shink, R., Shoemaker, D. H., Shoemaker, D. M., ShyamSundar, S., Siellez, K., Sieniawska, M., Sigg, D., Silva, A. D., Singer, L. P., Singh, N., Singhal, A., Sintes, A. M., Sitmukhambetov, S., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smith, J. R., Smith, R. J. E., Somala, S., Son, E. J., Sorazu, B., Sorrentino, F., Souradeep, T., Sowell, E., Spencer, A. P., Srivastava, A. 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A., Vahlbruch, H., Vajente, G., Valdes, G., van Bakel, N., van Beuzekom, M., Brand, J. F. J. van den, Broeck, C. Van Den, Vander-Hyde, D. C., van der Schaaf, L., van Heijningen, J. V., van Veggel, A. A., Vardaro, M., Varma, V., Vass, S., Vasuth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Venugopalan, G., Verkindt, D., Vetrano, F., Vicere, A., Viets, A. D., Vine, D. J., Vinet, J. -Y., Vitale, S., Vo, T., Vocca, H., Vorvick, C., Vyatchanin, S. P., Wade, A. R., Wade, L. E., Wade, M., Walet, R., Walker, M., Wallace, L., Walsh, S., Wang, G., Wang, H., Wang, J. Z., Wang, W. H., Wang, Y. F., Ward, R. L., Warden, Z. A., Warner, J., Was, M., Watchi, J., Weaver, B., Wei, L. -W., Weinert, M., Weinstein, A. J., Weiss, R., Wellmann, F., Wen, L., Wessel, E. K., Weels, P., Westhouse, J. W., Wette, K., Whelan, J. T., Whiting, B. F., Whittle, C., Wilken, D. M., Williams, D., Williamson, A. R., Willis, J. L., Willke, B., Wimmer, M. H., Winkler, W., Wipf, C. C., Wittel, H., Woan, G., Woehler, J., Wofford, J. K., Worden, J., Wright, J. L., Wu, D. S., Wysocki, D. M., Xiao, L., Yamamoto, H., Yancey, C. C., Yang, L., Yap, M. J., Yazback, M., Yeeles, D. W., Yu, Hang, Yu, Haocun, Yuen, S. H. R., Yvert, M., Zadrozny, A. K., Zadrozny, A., Zanolin, M., Zelenova, T., Zendri, J. -P., Zevin, M., Zhang, J., Zhang, L., Zhang, T., Zhao, C., Zhou, M., Zhou, Z., Zhu, X. J., Zucker, M. E., and Zweizig, J.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Astrophysical sources of gravitational waves, such as binary neutron star and black hole mergers or core-collapse supernovae, can drive relativistic outflows, giving rise to non-thermal high-energy emission. High-energy neutrinos are signatures of such outflows. The detection of gravitational waves and high-energy neutrinos from common sources could help establish the connection between the dynamics of the progenitor and the properties of the outflow. We searched for associated emission of gravitational waves and high-energy neutrinos from astrophysical transients with minimal assumptions using data from Advanced LIGO from its first observing run O1, and data from the ANTARES and IceCube neutrino observatories from the same time period. We focused on candidate events whose astrophysical origin could not be determined from a single messenger. We found no significant coincident candidate, which we used to constrain the rate density of astrophysical sources dependent on their gravitational wave and neutrino emission processes., Comment: 20 pages, 2 figures
Published: 2018
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11. Sensitivity of the KM3NeT/ARCA neutrino telescope to point-like neutrino sources

Author: The KM3NeT Collaboration, Aiello, S., Akrame, S. E., Ameli, F., Anassontzis, E. G., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Aublin, J., Avgitas, T., Bagatelas, C., Barbarino, G., Baret, B., Barrios-Martí, J., Belias, A., Berbee, E., Berg, A. van den, Bertin, V., Biagi, S., Biagioni, A., Biernoth, C., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M., Bozza, C., Brânzas, H., Bruchner, M., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Calvo, D., Capone, A., Celli, S., Chabab, M., Chau, N., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., D'Onofrio, A., Dallier, R., De Sio, C., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donà, R., Donzaud, C., Dornic, D., Dörr, M., Durocher, M., Eberl, T., van Eijk, D., Bojaddaini, I. El, Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Fermani, P., Ferrara, G., Filipovic, M. D., Fusco, L. A., Gal, T., Garcia, A., Garufi, F., Gialanella, L., Giorgio, E., Giuliante, A., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Grégoire, T., Grella, G., Hallmann, S., Hamdaoui, H., van Haren, H., Heid, T., Heijboer, A., Hekalo, A., Hernández-Rey, J. J., Hofestädt, J., Illuminati, G., James, C. W., Jongen, M., de Jong, M., de Jong, P., Kadler, M., Kalaczynski, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, Kiessling, D., Koffeman, E. N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Kunhikannan-Kannichankandy, M., Lahmann, R., Larosa, G., Breton, R. Le, Leone, F., Leonora, E., Levi, G., Lincetto, M., Lonardo, A., Longhitano, F., Coto, D. Lopez, Lotze, M., Maderer, L., Maggi, G., Manczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mele, R., Melis, K. W., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nielsen, C., Fearraigh, B. Ó, Organokov, M., Orlando, A., Ottonello, S., Panagopoulos, V., Papalashvili, G., Papaleo, R., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pikounis, K., Pisanti, O., Poirè, C., Polydefki, G., Popa, V., Post, M., Pradier, T., Pühlhofer, G., Pulvirenti, S., Quinn, L., Raffaelli, F., Randazzo, N., Razzaque, S., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Richer, M., Rigalleau, L., Rovelli, A., Saffer, M., Salvadori, I., Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schumann, J., Sciacca, V., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Strandberg, B., Stransky, D., Stüven, T., Taiuti, M., Tatone, F., Tayalati, Y., Tenllado, E., Thakore, T., Trovato, A., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., de Wolf, E., Zaborov, D., Zornoza, J. D., and Zúñiga, J.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: KM3NeT will be a network of deep-sea neutrino telescopes in the Mediterranean Sea. The KM3NeT/ARCA detector, to be installed at the Capo Passero site (Italy), is optimised for the detection of high-energy neutrinos of cosmic origin. Thanks to its geographical location on the Northern hemisphere, KM3NeT/ARCA can observe upgoing neutrinos from most of the Galactic Plane, including the Galactic Centre. Given its effective area and excellent pointing resolution, KM3NeT/ARCA will measure or significantly constrain the neutrino flux from potential astrophysical neutrino sources. At the same time, it will test flux predictions based on gamma-ray measurements and the assumption that the gamma-ray flux is of hadronic origin. Assuming this scenario, discovery potentials and sensitivities for a selected list of Galactic sources and to generic point sources with an $E^{-2}$ spectrum are presented. These spectra are assumed to be time independent. The results indicate that an observation with $3\sigma$ significance is possible in about six years of operation for the most intense sources, such as Supernovae Remnants RX\,J1713.7-3946 and Vela Jr. If no signal will be found during this time, the fraction of the gamma-ray flux coming from hadronic processes can be constrained to be below 50\% for these two objects., Comment: 32 pages, 9 figures, submitted to Astroparticle Physics
Published: 2018
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12. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

Author: Schell, John C, Wisidagama, Dona R, Bensard, Claire, Zhao, Helong, Wei, Peng, Tanner, Jason, Flores, Aimee, Mohlman, Jeffrey, Sorensen, Lise K, Earl, Christian S, Olson, Kristofor A, Miao, Ren, Waller, T Cameron, Delker, Don, Kanth, Priyanka, Jiang, Lei, DeBerardinis, Ralph J, Bronner, Mary P, Li, Dean Y, Cox, James E, Christofk, Heather R, Lowry, William E, Thummel, Carl S, and Rutter, Jared
Subjects: Biochemistry and Cell Biology, Biological Sciences, Digestive Diseases, Regenerative Medicine, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Generic health relevance, Acrylates, Animals, Anion Transport Proteins, Cell Differentiation, Cell Proliferation, Cells, Cultured, Drosophila Proteins, Drosophila melanogaster, Genotype, Glycolysis, Humans, Intestinal Mucosa, Intestines, Lactic Acid, Mice, Knockout, Mitochondria, Mitochondrial Membrane Transport Proteins, Mitochondrial Proteins, Monocarboxylic Acid Transporters, Phenotype, Pyruvic Acid, RNA Interference, Receptors, G-Protein-Coupled, Signal Transduction, Stem Cells, Time Factors, Tissue Culture Techniques, Transfection, Medical and Health Sciences, Developmental Biology, Biochemistry and cell biology
Abstract: Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient mitochondrial pyruvate uptake. In contrast, proliferative cells, including many cancer and stem cells, perform glycolysis robustly but limit fractional mitochondrial pyruvate oxidation. We sought to understand the role this transition from glycolysis to pyruvate oxidation plays in stem cell maintenance and differentiation. Loss of the MPC in Lgr5-EGFP-positive stem cells, or treatment of intestinal organoids with an MPC inhibitor, increases proliferation and expands the stem cell compartment. Similarly, genetic deletion of the MPC in Drosophila intestinal stem cells also increases proliferation, whereas MPC overexpression suppresses stem cell proliferation. These data demonstrate that limiting mitochondrial pyruvate metabolism is necessary and sufficient to maintain the proliferation of intestinal stem cells.
Published: 2017

13. An Overview of the Management of Drug-Resistant Tuberculosis in Six French-Speaking African Countries from 2018 to 2022.

Author: Badoum, Gisèle, Ouédraogo, Abdoul R., Fiogbé, Attannon A., Kuate Kuate, Albert, Soumana, Alphazazi, Diop, Yacine Mar, Dogo, Mohammed F., Mbitikon, Olivia B., Combary, Adjima, Agodokpessi, Gildas, Affolabi, Dissou, Bisso, Annie, Atimbada, Dona R., Menon, Sonia, and Koura, Kobto G.
Published: 2024
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14. gSeaGen: The KM3NeT GENIE-based code for neutrino telescopes

Author: Aiello, S., Albert, A., Garre, S. Alves, Aly, Z., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Anton, G., Ardid, M., Aublin, J., Bagatelas, C., Barbarino, G., Baret, B., Basegmez du Pree, S., Bendahman, M., Berbee, E., van den Berg, A.M., Bertin, V., Biagi, S., Biagioni, A., Bissinger, M., Boettcher, M., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruchner, M., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Calvo, D., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J.A.B., Coleiro, A., Molla, M. Colomer, Coniglione, R., Corredoira, I., Coyle, P., Creusot, A., Cuttone, G., D’Onofrio, A., Dallier, R., De Palma, M., Di Palma, I., Díaz, A.F., Diego-Tortosa, D., Distefano, C., Domi, A., Donà, R., Donzaud, C., Dornic, D., Dörr, M., Drouhin, D., Durocher, M., Eberl, T., van Eijk, D., El Bojaddaini, I., Elsaesser, D., Enzenhöfer, A., Roselló, V. Espinosa, Fermani, P., Ferrara, G., Filipović, M.D., Filippini, F., Franco, A., Fusco, L.A., Gabella, O., Gal, T., Soto, A. Garcia, Garufi, F., Gatelet, Y., Geißelbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S.R., Gracia, R., Graf, K., Grasso, D., Grella, G., Guderian, D., Guidi, C., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hernández-Rey, J.J., Hofestädt, J., Huang, F., Ibnsalih, W. Idrissi, Illuminati, G., James, C.W., de Jong, M., de Jong, P., Jung, B.J., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U.F., Chowdhury, N.R. Khan, van der Knaap, F., Koffeman, E.N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Larosa, G., Le Breton, R., Leonardi, O., Leone, F., Leonora, E., Levi, G., Lincetto, M., Lindsey Clark, M., Lipreau, T., Lonardo, A., Longhitano, F., Lopez-Coto, D., Maderer, L., Mańczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J.A., Martini, A., Marzaioli, F., Mastroianni, S., Mazzou, S., Melis, K.W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L.S., Modebadze, Z., Mollo, C.M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C.A., Ó Fearraigh, B., Organokov, M., Orlando, A., Papalashvili, G., Papaleo, R., Pastore, C., Paun, A.M., Păvălaş, G.E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Pikounis, K., Pisanti, O., Poirè, C., Popa, V., Post, M., Pradier, T., Pühlhofer, G., Pulvirenti, S., Quinn, L., Rabyang, O., Raffaelli, F., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Reubelt, J., Riccobene, G., Richer, M., Rivoire, S., Rovelli, A., Greus, F. Salesa, Samtleben, D.F.E., Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schnabel, J., Sciacca, V., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S.M., Taiuti, M., Tayalati, Y., Tenllado, E., Thakore, T., Tingay, S., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Vannoye, G., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Zaborov, D., Zavatarelli, S., Zegarelli, A., Zornoza, J.D., Zúñiga, J., and Zywucka, N.
Published: 2020
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15. The Control Unit of the KM3NeT Data Acquisition System

Author: Aiello, S., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Aublin, J., Bagatelas, C., Barbarino, G., Baret, B., du Pree, S. Basegmez, Bendahman, M., Berbee, E., van den Berg, A.M., Bertin, V., van Beveren, V., Biagi, S., Biagioni, A., Bissinger, M., Boumaaza, J., Bourret, S., Bouta, M., Bouvet, G., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruchner, M., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Calvo, D., Capone, A., Celli, S., Chabab, M., Chau, N., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J.A.B., Coleiro, A., Molla, M. Colomer, Colonges, S., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., D’Onofrio, A., Dallier, R., De Palma, M., Di Palma, I., Díaz, A.F., Diego-Tortosa, D., Distefano, C., Domi, A., Donà, R., Donzaud, C., Dornic, D., Dörr, M., Durocher, M., Eberl, T., El Bojaddaini, I., Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Fermani, P., Ferrara, G., Filipović, M.D., Franco, A., Fusco, L.A., Gal, T., Soto, A. Garcia, Garufi, F., Gialanella, L., Giorgio, E., Gozzini, S.R., Gracia, R., Graf, K., Grasso, D., Grégoire, T., Grella, G., Guderian, D., Guidi, C., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hernández-Rey, J.J., Hofestädt, J., Huang, F., Illuminati, G., James, C.W., Jansweijer, P., de Jong, M., de Jong, P., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U.F., Chowdhury, N.R. Khan, van der Knaap, F., Koffeman, E.N., Kooijman, P., Kouchner, A., Kulikovskiy, V., Lahmann, R., Larosa, G., Le Breton, R., Leone, F., Leonora, E., Levi, G., Lincetto, M., Clark, M. Lindsey, Lonardo, A., Longhitano, F., Lopez-Coto, D., Maggi, G., Mańczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martignac, G., Martin, L., Martínez-Mora, J.A., Martini, A., Marzaioli, F., Mazzou, S., Mele, R., Melis, K.W., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L.S., Mollo, C.M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C.A., Nielsen, C., Ó Fearraigh, B., Organokov, M., Orlando, A., Panagopoulos, V., Papalashvili, G., Papaleo, R., Pastore, C., Păvălaş, G.E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Pikounis, K., Pisanti, O., Poirè, C., Polydefki, G., Popa, V., Post, M., Pradier, T., Pühlhofer, G., Pulvirenti, S., Quinn, L., Raffaelli, F., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Reubelt, J., Riccobene, G., Richer, M., Rigalleau, L., Rovelli, A., Salvadori, I., Samtleben, D.F.E., Sánchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schnabel, J., Sciacca, V., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S.M., Strandberg, B., Stransky, D., Taiuti, M., Tayalati, Y., Tenllado, E., Thakore, T., Tingay, S., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Vannoye, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Zaborov, D., Zegarelli, A., Zornoza, J.D., and Zúñiga, J.
Published: 2020
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16. Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

Author: Bensard, Claire L., Wisidagama, Dona R., Olson, Kristofor A., Berg, Jordan A., Krah, Nathan M., Schell, John C., Nowinski, Sara M., Fogarty, Sarah, Bott, Alex J., Wei, Peng, Dove, Katja K., Tanner, Jason M., Panic, Vanja, Cluntun, Ahmad, Lettlova, Sandra, Earl, Christian S., Namnath, David F., Vázquez-Arreguín, Karina, Villanueva, Claudio J., Tantin, Dean, Murtaugh, L. Charles, Evason, Kimberley J., Ducker, Gregory S., Thummel, Carl S., and Rutter, Jared
Published: 2020
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17. Sensitivity of the KM3NeT/ARCA neutrino telescope to point-like neutrino sources

Author: Aiello, S., Akrame, S.E., Ameli, F., G. Anassontzis, E., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Aublin, J., Avgitas, T., Bagatelas, C., Barbarino, G., Baret, B., Barrios-Martí, J., Belias, A., Berbee, E., van den Berg, A., Bertin, V., Biagi, S., Biagioni, A., Biernoth, C., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruchner, M., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Calvo, D., Capone, A., Celli, S., Chabab, M., Chau, N., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J.A.B., Coleiro, A., Molla, M. Colomer, Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., D’Onofrio, A., Dallier, R., De Sio, C., Di Palma, I., Díaz, A.F., Diego-Tortosa, D., Distefano, C., Domi, A., Donà, R., Donzaud, C., Dornic, D., Dörr, M., Durocher, M., Eberl, T., van Eijk, D., El Bojaddaini, I., Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Fermani, P., Ferrara, G., D. Filipović, M., Fusco, L.A., Gal, T., Garcia, A., Garufi, F., Gialanella, L., Giorgio, E., Giuliante, A., Gozzini, S.R., Gracia, R., Graf, K., Grasso, D., Grégoire, T., Grella, G., Hallmann, S., Hamdaoui, H., van Haren, H., Heid, T., Heijboer, A., Hekalo, A., Hernández-Rey, J.J., Hofestädt, J., Illuminati, G., James, C.W., Jongen, M., de Jong, M., de Jong, P., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U.F., Khan Chowdhury, N.R., Kießling, D., Koffeman, E.N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Kunhikannan Kannichankandy, M., Lahmann, R., Larosa, G., Le Breton, R., Leone, F., Leonora, E., Levi, G., Lincetto, M., Lonardo, A., Longhitano, F., Lopez Coto, D., Lotze, M., Maderer, L., Maggi, G., Mańczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J.A., Martini, A., Marzaioli, F., Mele, R., Melis, K.W., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L.S., Mollo, C.M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C.A., Nielsen, C., Ó Fearraigh, B., Organokov, M., Orlando, A., Ottonello, S., Panagopoulos, V., Papalashvili, G., Papaleo, R., Păvălaş, G.E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pikounis, K., Pisanti, O., Poiré, C., Polydefki, G., Popa, V., Post, M., Pradier, T., Pühlhofer, G., Pulvirenti, S., Quinn, L., Raffaelli, F., Randazzo, N., Razzaque, S., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Richer, M., Rigalleau, L., Rovelli, A., Saffer, M., Salvadori, I., Samtleben, D.F.E., Sánchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schumann, J., Sciacca, V., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S.M., Strandberg, B., Stransky, D., Stüven, T., Taiuti, M., Tatone, F., Tayalati, Y., Tenllado, E., Thakore, T., Trovato, A., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., de Wolf, E., Zaborov, D., Zornoza, J.D., and Zúñiga, J.
Published: 2019
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18. Biomarker-guided trials: challenges in practice

Author: M, Antoniou, Kolamunnage-Dona, R., J, Wason, R, Bathia, C, Billingham, JM, Bliss, LC, Brown, A, Gillman, J, Paul, and AL, Jorgensen
Published: 2019
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19. Regulation of Drosophila Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism

Author: Dona R. Wisidagama and Carl S. Thummel
Subjects: mitochondria, intestinal homeostasis, metabolism, stem cells, Genetics, QH426-470
Abstract: Multiple signaling pathways in the adult Drosophila enterocyte sense cellular damage or stress and signal to intestinal stem cells (ISCs) to undergo proliferation and differentiation, thereby maintaining intestinal homeostasis. Here we show that misregulation of mitochondrial pyruvate metabolism in enterocytes can stimulate ISC proliferation and differentiation. Our studies focus on the Mitochondrial Pyruvate Carrier (MPC), which is an evolutionarily-conserved protein complex that resides in the inner mitochondrial membrane and transports cytoplasmic pyruvate into the mitochondrial matrix. Loss of MPC function in enterocytes induces Unpaired cytokine expression, which activates the JAK/STAT pathway in ISCs, promoting their proliferation. Upd3 and JNK signaling are required in enterocytes for ISC proliferation, indicating that this reflects a canonical non-cell autonomous damage response. Disruption of lactate dehydrogenase in enterocytes has no effect on ISC proliferation but it suppresses the proliferative response to a loss of enterocyte MPC function, suggesting that lactate contributes to this pathway. These studies define an important role for cellular pyruvate metabolism in differentiated enterocytes to maintain stem cell proliferation rates.
Published: 2019
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20. Experimental evidence of antiproton reflection by a solid surface

Author: Bianconi, A., Corradini, M., Cristiano, A., Leali, M., Rizzini, E. Lodi, Venturelli, L., Zurlo, N., and Dona, R
Subjects: High Energy Physics - Experiment
Abstract: We report here experimental evidence of the reflection of a large fraction of a beam of low energy antiprotons by an aluminum wall. This derives from the analysis of a set of annihilations of antiprotons that come to rest in rarefied helium gas after hitting the end wall of the apparatus. A Monte Carlo simulation of the antiproton path in aluminum indicates that the observed reflection occurs primarily via a multiple Rutherford-style scattering on Al nuclei, at least in the energy range 1-10 keV where the phenomenon is most visible in the analyzed data. These results contradict the common belief according to which the interactions between matter and antimatter are dominated by the reciprocally destructive phenomenon of annihilation., Comment: 5 pages with 5 figures
Published: 2008
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21. Fibre Bragg Gratings to monitor the deformations of a silicon microstrip vertex detector

Author: Donà, R. and Lorenzini, M.
Published: 2018
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22. Present knowledge of the Cabibbo-Kobayashi-Maskawa matrix

Author: Bargiotti, M., Bertin, A., Bruschi, M., Capponi, M., De Castro, S., Dona', R., Faccioli, P., Galli, D., Giacobbe, B., Marconi, U., Massa, I., Piccinini, M., Poli, M., Semprini-Cesari, N., Spighi, R., Vagnoni, V., Vecchi, S., Villa, M., Vitale, A., and Zoccoli, A.
Subjects: High Energy Physics - Phenomenology
Abstract: A complete review of the Cabibbo-Kobayashi-Maskawa (CKM) matrix elements and of the experimental methods for their determination is presented. A critical analysis of the relevant experimental results, and in particular of the most recent ones, allows to improve the accuracies of all the matrix elements. A chi-square minimization with the three-family unitarity constraint on the CKM matrix is performed to test the current interpretation of the CP violating phenomena inside the Standard Model. A complete and unambiguous solution satisfying all the imposed constraints is found. As a by-product of the fit, the precision on the values of the matrix elements is further increased and it is possible to obtain estimates for the important CP violation observables $sin 2\beta$, $sin 2\alpha$ and $\gamma$. Finally, an independent estimation of the CKM elements based on a Bayesian approach is performed. This complementary method constitutes a check of the results obtained, providing also the probability functions of the CKM elements and of the related quantities., Comment: 81 pages, 1 file (with 15 figures); v2: misprints corrected on pages 32 & 35
Published: 2000
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23. Flow angle from intermediate mass fragment measurements

Author: Rami, F., Crochet, P., Dona, R., de Schauenburg, B., Wagner, P., and Collaboration, the FOPI
Subjects: Nuclear Experiment
Abstract: Directed sideward flow of light charged particles and intermediate mass fragments was measured in different symmetric reactions at bombarding energies from 90 to 800 AMeV. The flow parameter is found to increase with the charge of the detected fragment up to Z = 3-4 and then turns into saturation for heavier fragments. Guided by simple simulations of an anisotropic expanding thermal source, we show that the value at saturation can provide a good estimate of the flow angle, $\Theta_{flow}$, in the participant region. It is found that $\Theta_{flow}$ depends strongly on the impact parameter. The excitation function of $\Theta_{flow}$ reveals striking deviations from the ideal hydrodynamical scaling. The data exhibit a steep rise of $\Theta_{\flow}$ to a maximum at around 250-400 AMeV, followed by a moderate decrease as the bombarding energy increases further., Comment: 28 pages Revtex, 6 figures (ps files), to appear in Nucl.Phys.A
Published: 1998
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24. Azimuthal Anisotropies as Stringent Test for Nuclear Transport Models

Author: Crochet, P., Rami, F., Dona, R., and Collaboration, the FOPI
Subjects: Nuclear Experiment
Abstract: Azimuthal distributions of charged particles and intermediate mass fragments emitted in Au+Au collisions at 600AMeV have been measured using the FOPI facility at GSI-Darmstadt. Data show a strong increase of the in-plane azimuthal anisotropy ratio with the charge of the detected fragment. Intermediate mass fragments are found to exhibit a strong momentum-space alignment with respect of the reaction plane. The experimental results are presented as a function of the polar center-of-mass angle and over a broad range of impact parameters. They are compared to the predictions of the Isospin Quantum Molecular Dynamics model using three different parametrisations of the equation of state. We show that such highly accurate data provide stringent test for microscopic transport models and can potentially constrain separately the stiffness of the nuclear equation of state and the momentum dependence of the nuclear interaction., Comment: 26 pages Revtex, 7 ps-figures, to appear in Nucl.Phys.A
Published: 1997
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25. Onset of Nuclear Matter Expansion in Au+Au Collisions

Author: Crochet, P., Rami, F., Gobbi, A., Dona, R., and Collaboration, the FOPI
Subjects: Nuclear Experiment
Abstract: Using the FOPI detector at GSI Darmstadt, excitation functions of collective flow components were measured for the Au+Au system, in the reaction plane and out of this plane, at seven incident energies ranging from 100AMeV to 800AMeV. The threshold energies, corresponding to the onset of sideward-flow (balance energy) and squeeze-out effect (transition energy), are extracted from extrapolations of these excitation functions toward lower beam energies for charged products with Z>2. The transition energy is found to be larger than the balance energy. The impact parameter dependence of both balance and transition energies, when extrapolated to central collisions, suggests comparable although slightly higher values than the threshold energy for the radial flow. The relevant parameter seems to be the energy deposited into the system in order to overcome the attractive nuclear forces., Comment: 26 pages Revtex, 6 ps-figures, to appear in Nucl.Phys.A
Published: 1997
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26. Abundance of Delta Resonances in 58Ni+58Ni Collisions between 1 and 2 AGeV

Author: FOPI Collaboration, Hong, B., Herrmann, N., Ritman, J. L., Best, D., Gobbi, A., Hildenbrand, K. D., Kirejczyk, M., Leifels, Y., Pinkenburg, C., Reisdorf, W., Schuell, D., Sodan, U., Wang, G. S., Wienold, T., Alard, J. P., Amouroux, V., Bastid, N., Belyaev, I., Berek, G., Biegansky, J., Buta, A., Coffin, J. P., Crochet, P., Dona, R., Dupieux, P., Eskef, M., Fintz, P., Fodor, Z., Fraysse, L., Genoux-Lubain, A., Goebels, G., Guillaume, G., Haefele, E., Jundt, F., Kecskemeti, J., Korolija, M., Kotte, R., Kuhn, C., Lebedev, A., Legrand, I., Maazouzi, C., Manko, V., Moesner, J., Mohren, S., Neubert, W., Pelte, D., Petrovici, M., Pras, P., Rami, F., Roy, C., Seres, Z., Sikora, B., Simion, V., Siwek-Wilczynska, K., Somov, A., Tizniti, L., Trzaska, M., Vasiliev, M. A., Wagner, P., Wohlfarth, D., and Zhilin, A.
Subjects: Nuclear Experiment
Abstract: Charged pion spectra measured in 58Ni-58Ni collisions at 1.06, 1.45 and 1.93 AGeV are interpreted in terms of a thermal model including the decay of Delta resonances. The transverse momentum spectra of pions are well reproduced by adding the pions originating from the Delta-resonance decay to the component of thermal pions, deduced from the high transverse momentum part of the pion spectra. About 10 and 18% of the nucleons are excited to Delta states at freeze-out for beam energies of 1 and 2 AGeV, respectively., Comment: 14 pages, LaTeX with 3 included figures; submitted to Physics Letters B
Published: 1997
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27. An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

Author: McCommis, Kyle S., Hodges, Wesley T., Bricker, Daniel K., Wisidagama, Dona R., Compan, Vincent, Remedi, Maria S., Thummel, Carl S., and Finck, Brian N.
Published: 2016
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28. An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

Author: Kyle S. McCommis, Wesley T. Hodges, Daniel K. Bricker, Dona R. Wisidagama, Vincent Compan, Maria S. Remedi, Carl S. Thummel, and Brian N. Finck
Subjects: Internal medicine, RC31-1245
Abstract: Objective: Transport of pyruvate into the mitochondrial matrix by the Mitochondrial Pyruvate Carrier (MPC) is an important and rate-limiting step in its metabolism. In pancreatic β-cells, mitochondrial pyruvate metabolism is thought to be important for glucose sensing and glucose-stimulated insulin secretion. Methods: To evaluate the role that the MPC plays in maintaining systemic glucose homeostasis, we used genetically-engineered Drosophila and mice with loss of MPC activity in insulin-producing cells. Results: In both species, MPC deficiency results in elevated blood sugar concentrations and glucose intolerance accompanied by impaired glucose-stimulated insulin secretion. In mouse islets, β-cell MPC-deficiency resulted in decreased respiration with glucose, ATP-sensitive potassium (KATP) channel hyperactivity, and impaired insulin release. Moreover, treatment of pancreas-specific MPC knockout mice with glibenclamide, a sulfonylurea KATP channel inhibitor, improved defects in islet insulin secretion and abnormalities in glucose homeostasis in vivo. Finally, using a recently-developed biosensor for MPC activity, we show that the MPC is rapidly stimulated by glucose treatment in INS-1 insulinoma cells suggesting that glucose sensing is coupled to mitochondrial pyruvate carrier activity. Conclusions: Altogether, these studies suggest that the MPC plays an important and ancestral role in insulin-secreting cells in mediating glucose sensing, regulating insulin secretion, and controlling systemic glycemia. Keywords: Stimulus-coupled secretion, Insulin, β-Cell, Diabetes, Pyruvate, Mitochondria, Drosophila
Published: 2016
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29. External validation and recalibration of an incidental meningioma prognostic model - IMPACT: protocol for an international multicentre retrospective cohort study.

Author: Islim, AI, Millward, CP, Piper, RJ, Fountain, DM, Mehta, S, Kolamunnage-Dona, R, Ali, U, Koszdin, SD, Georgious, T, Mills, SJ, Brodbelt, AR, Mathew, RK, Santarius, T, Jenkinson, MD, IMPACT Study Investigators, International Consortium on Meningioma (ICOM) and British Neurosurgical Trainee Research Collaborative (BNTRC), Islim, AI, Millward, CP, Piper, RJ, Fountain, DM, Mehta, S, Kolamunnage-Dona, R, Ali, U, Koszdin, SD, Georgious, T, Mills, SJ, Brodbelt, AR, Mathew, RK, Santarius, T, Jenkinson, MD, and IMPACT Study Investigators, International Consortium on Meningioma (ICOM) and British Neurosurgical Trainee Research Collaborative (BNTRC)
Abstract: INTRODUCTION: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an estimated prevalence of 3/1000. The management of incidental meningioma varies widely with active clinical-radiological monitoring being the most accepted method by clinicians. Duration of monitoring and time intervals for assessment, however, are not well defined. To this end, we have recently developed a statistical model of progression risk based on single-centre retrospective data. The model Incidental Meningioma: Prognostic Analysis Using Patient Comorbidity and MRI Tests (IMPACT) employs baseline clinical and imaging features to categorise the patient with an incidental meningioma into one of three risk groups: low, medium and high risk with a proposed active monitoring strategy based on the risk and temporal trajectory of progression, accounting for actuarial life expectancy. The primary aim of this study is to assess the external validity of this model. METHODS AND ANALYSIS: IMPACT is a retrospective multicentre study which will aim to include 1500 patients with an incidental intracranial meningioma, powered to detect a 10% progression risk. Adult patients ≥16 years diagnosed with an incidental meningioma between 1 January 2009 and 31 December 2010 will be included. Clinical and radiological data will be collected longitudinally until the patient reaches one of the study endpoints: intervention (surgery, stereotactic radiosurgery or fractionated radiotherapy), mortality or last date of follow-up. Data will be uploaded to an online Research Electronic Data Capture database with no unique identifiers. External validity of IMPACT will be tested using established statistical methods. ETHICS AND DISSEMINATION: Local institutional approval at each participating centre will be required. Results of the study will be reported through peer-revi
Published: 2022

30. Planning Your Staffing Needs: A Handbook for Personnel Workers.

Author: Civil Service Commission, Washington, DC. Bureau of Policies and Standards., Clark, Harry L., and Thurston, Dona R.
Abstract: Staffing needs planning, as distinct from workforce planning, is the systematic estimation of the actions personnel managers must take to provide the required workforce in an organization. This handbook focuses on the pivotal aspects of staffing needs planning, including estimation of future vacancies and analysis and projection of employee turnover. The first section of the book briefly introduces staffing needs planning and the policy issues related to it. The second section explains details of manual methods of projecting turnover losses, including the nature of the retention curve and fitting and using the log-probability curve. Section 3 presents computer methods for analyzing turnover, advancement, and hiring needs, including LOGPRO, LPFILE, LPTEST, GS810, and HIREST. The handbook is designed for use by those with limited statistical training as well as by those who are technically proficient. The computer programs are intended to be general in application, complete, compact, simple, and fully documented. Appendices provide detailed documentation on the manual methods and the computer programs, including full computer program listings, operation manuals, and technical analysis. (Author/JM)
Published: 1977

31. Search for Multimessenger Sources of Gravitational Waves and High-energy Neutrinos with Advanced LIGO during Its First Observing Run, ANTARES, and IceCube

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A, Steinke, M, Steinlechner, J, Steinlechner, S, Steinmeyer, D, Stevenson, S. P, Stocks, D, Stone, R, Stops, D. J, Strain, K. A, Stratta, G, Strigin, S. E, Strunk, A, Sturani, R, Stuver, A. L, Sudhir, V and Summerscales, T. Z., Sun, L, Sunil, S, Suresh, J, Sutton, P. J, Swinkels, B. L, Szczepanczyk, M. J, Tacca, M, Tait, S. C, Talbot, C, Talukder, D, Tanner, D. B, Tapai, M, Taracchini, A, Tasson, J. D, Taylor, R, Thies, F, Thomas, M, Thomas, P, Thondapu, S. R, Thorne, K. A, Thrane, E, Tiwari, Shubhanshu and Tiwari, Srishti and Tiwari, V and Toland, Tonelli, M, Tornasi, Z, Torres-Forne, A, Torrie, Toyra, D, Travasso, F, Traylor, G, Tringali, M. C, Trozzo, L, Trudeau, R, Tsang, K. W, Tse, M, Tso, R, Tsukada, L, Tsuna, D, Tuyenbayev, D, Ueno, K, Ugolini, D, Unnikrishnan, C. S, Urban, A. L, Usman, S. A, Vahlbruch, H, Vajente, G, Valdes, G, van Bakel, N, van Beuzekom, M, van den Brand, J. F. J, Van Den Broeck, C, Vander-Hyde, D. C, van der Schaaf, L, Van, Heijningen, van Veggel, A. A, Vardaro, M, Varma, V, Vass, S, Vasuth, M, Vecchio, A, Vedovato, G, Veitch, J, Veitch, P. J, Venkateswara, K, Venugopalan, G, Verkindt, D, Vetrano, F, Vicere, A, Viets, A. D, Vine, D. J, Vinet, J-Y and Vitale, Vo, T, Vocca, H, Vorvick, C, Vyatchanin, S. P, Wade, A. R, Wade, L. E, Wade, M, Walet, R, Walker, M, Wallace, L, Walsh, S, Wang, G, Wang, H, Wang, J. Z, Wang, W. H, Wang, Y. F, Ward, R. L, Warden, Z. A, Warner, J, Was, M, Watchi, J, Weaver, B, Wei, L-W and Weinert, Weinstein, A. J, Weiss, R, Wellmann, F, Wen, L, Wessel, E. K, Wessels, P, Westhouse, J. W, Wette, K, Whelan, J. T, Whiting, B. F, Whittle, C, Wilken, D. M, Williams, D, Williamson, A. R, Willis, J. L, Willke, B, Wimmer, M. H, Winkler, W, Wipf, C. C, Wittel, H, Woan, G, Woehler, J, Wofford, J. K, Worden, J, Wright, J. L, D. S, Wu, Wysocki, D. M, Xiao, L, Yamamoto, H, Yancey, C. C, Yang, L, Yap, M. J, Yazback, M, Yeeles, D. W, Hang and Yu, Haocun and Yuen, S. H. R., Yvert, M, Zadrozny, A. 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C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., El Moursli, R. Cherkaoui, Chiarusi, T., Circella, M., Coelho, J. A. B., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Díaz, A. F., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Donà, R., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., El Bojaddaini, I., El Khayati, N., Elsässer, D., Enzenhöfer, A., Ettahiri, A., Fassi, F., Felis, I., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Grégoire, T., Ruiz, R. Gracia, Graf, K., Hallmann, S., Van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Illuminati, G., De Jong, M., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Lahmann, R., Lefèvre, D., Leonora, E., Levi, G., Lotze, M., Loucatos, S., Maggi, G., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nuñez, A., Organokov, M., Pǎvǎlaş, G. E., Pellegrino, C., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sánchez-Losa, A., Saldaña, M., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Trovato, A., Vallage, B., Van Elewyck, V., Versari, F., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., Zñiga, J., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Backes, P., Bagherpour, H., Bai, X., Barbano, A., Barron, J. P., Barwick, S. 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D., Vasuth, M., Vicere, A., Wessels, P., Yu, H., Zadrozny, A., Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut Universitaire de Technologie de Colmar, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Collège de France (CdF)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), ESPCI ParisTech, Andre, M, Aubert, Jj, Barrios-Marti, J, Bouwhuis, Mc, Branzas, H, El Moursli, Rc, Coelho, Jab, Diaz, Af, Dona, R, Elsasser, D, Enzenhofer, A, Gregoire, T, Ruiz, Rg, van Haren, H, Heijboer, Aj, Hernandez-Rey, Jj, Hossl, J, Hofestadt, J, de Jong, M, Khan-Chowdhury, Nr, Lefevre, D, Martinez-Mora, Ja, Nunez, A, Pavalas, Ge, Sanchez-Losa, A, Saldana, M, Samtleben, Dfe, Schussler, F, Zornoza, Jd, Zuniga, J, Aartsen, Mg, Aguilar, Ja, Arguelles, C, Barron, Jp, Barwick, Sw, Beatty, Jj, Tjus, Jb, Becker, Kh, Besson, Dz, Borner, M, Boser, S, Bretz, Hp, Collin, Gh, Conrad, Jm, Cowen, Df, de Andre, Jpam, Delaunay, Jj, de Vries, Kd, de Wasseige, G, de With, M, Diaz-Velez, Jc, di Lorenzo, V, Dumm, Jp, Evenson, Pa, Fazely, Ar, Gaisser, Tk, Glusenkamp, T, Gonzalez, Jg, Hill, Gc, Hoffman, Kd, Hunnefeld, M, Jones, Bjp, Kelley, Jl, Klein, Sr, Kopke, L, Koschinsky, Jp, Koskinen, Dj, Kruckl, G, Lanfranchi, Jl, Larson, Mj, Liu, Qr, Mariscal, Cjl, Lunemann, J, Mahn, Kbm, Maris, Ic, Momente, G, Moore, Rw, Nowicki, Sc, Nygren, Dr, Pollmann, Ao, Pankova, Dv, Pepper, Ja, de los Heros, Cp, Price, Pb, Przybylski, Gt, Rea, Ic, Herrera, Se, Schoneberg, S, Spiczak, Gm, Stokstad, Rg, Stossl, A, Strotjohann, Nl, Sullivan, Gw, Toale, Pa, Tobin, Mn, Tonnis, C, Tung, Cf, Turley, Cf, Elorrieta, Mau, van Eijk, D, van Eijndhoven, N, van Santen, J, Wandler, Fd, Watson, Tb, Weiss, Mj, Whelan, Bj, Wiebusch, Ch, Williams, Dr, Wood, Tr, Xu, Dl, Xu, Xw, Yanez, Jp, Abbott, Bp, Abbott, Td, Adya, Vb, Aguiar, Od, Aloy, Ma, Altin, Pa, Anderson, Sb, Anderson, Wg, Angelova, Sv, Araya, Mc, Arene, M, Arun, Kg, Aston, Sm, Bader, Mkm, Baker, Pt, Ballmer, Sw, Barayoga, Jc, Barclay, Se, Barish, Bc, Bayley, Jc, Becsy, B, Berger, Bk, Bero, Jj, Berry, Cpl, Bilenko, Ia, Bilgili, Sa, Bizouard, Ma, Blackburn, Jk, Blair, Cd, Blair, Dg, Blair, Rm, Boom, Ba, Booth, Cd, Brady, Pr, Brau, Je, Briggs, Jh, Brooks, Af, Brown, Dd, Bulten, Hj, Byer, Rl, Bustillo, Jc, Callister, Ta, Camp, Jb, Campbell, Wa, Cannon, Kc, Carney, Mf, Diaz, Jc, Cavaglia, M, Cerda-Duran, P, Chamberlin, Sj, Chase, Ea, Cheeseboro, Bd, Chen, Hy, Cheng, Hp, Cheong, Ck, Chia, Hy, Chung, Kw, Ciobanu, Aa, Clark, Ja, Cohadon, Pf, Collette, Cg, Cominsky, Lr, Cooper, Sj, Corbitt, Tr, Cordero-Carrion, I, Corley, Kr, Costa, Ca, Coughlin, Mw, Coughlin, Sb, Coulon, Jp, Countryman, St, Covas, Pb, Cowan, Ee, Coward, Dm, Cowart, Mj, Coyne, Dc, Creighton, Jde, Creighton, Td, Crowder, Sg, Cullen, Tj, Dal Canton, T, Dalya, G, Danilishin, Sl, Costa, Cfd, Datrier, Leh, Daw, Ej, Deleglise, S, Del Pozzo, W, Demarchi, Lm, de Varona, O, Diaz, Mc, Di Fiore, L, Di Giovanni, M, Di Girolamo, T, Di Lieto, A, Di Pace, S, Di Renzo, F, Dooley, Kl, Downes, Tp, Driggers, Jc, Ducoin, Jg, Dwyer, Se, Easter, Pj, Edo, Tb, Edwards, Mc, Eisenstein, Ra, Essick, Rc, Etienne, Zb, Evans, Tm, Farr, Wm, Fauchon-Jones, Ej, Fejer, Mm, Ferreira, Ec, Ferreira, Ta, Fisher, Rp, Fishner, Jm, Font, Ja, Forsyth, Pwf, Fournier, Jd, Frolov, Vv, Gabbard, Ha, Gadre, Bu, Gaebel, Sm, Gair, Jr, Ganija, Mr, Gaonkar, Sg, Garcia-Quiros, C, Giaime, Ja, Giardina, Kd, Gonzalez, G, Castro, Jmg, Gorodetsky, Ml, Gossan, Se, Green, Ac, Gretarsson, Em, Guidi, Gm, Gulati, Hk, Gupta, Mk, Gustafson, Ek, Hall, Br, Hall, Ed, Hamilton, Ez, Hanke, Mm, Hannuksela, Oa, Harry, Gm, Harry, Iw, Haster, Cj, Hayes, Fj, Heintze, Mc, Heptonstall, Aw, Hernandez, Fj, Holgado, Am, Holland, Na, Holz, De, Howell, Ej, Hoy, Cg, Huerta, Ea, Huttner, Sh, Isa, Hn, Isac, Jm, Iyer, Br, Jadhav, Sj, Janthalur, Nn, Jenkins, Ac, Jones, Aw, Jones, Di, Jonker, Rjg, Kalaghatgi, Cv, Kanner, Jb, Kapadia, Sj, Keerthana, Nv, Kefelian, F, Khalili, Fy, Khazanov, Ea, Kim, Jc, Kim, Ym, King, Ej, King, Pj, Klika, Jh, Knowles, Td, Koehlenbeck, Sm, Korth, Wz, Kozak, Db, Krolak, A, Lackey, Bd, Lai, Kh, Lam, Tl, Lane, Bb, Lang, Rn, Lanza, Rk, Lasky, Pd, Lecoeuche, Yk, Lee, Ch, Lee, Hk, Lee, Hm, Lee, Hw, Li, Kjl, Li, Tgf, Linker, Sd, Littenberg, Tb, Lo, Rkl, Lockerbie, Na, London, Lt, Lough, Jd, Lousto, Co, Lower, Me, Luck, H, Lundgren, Ap, Macleod, Dm, Magana-Sandoval, F, Zertuche, Lm, Magee, Rm, Mansell, Gl, Marka, S, Marka, Z, Martin, Iw, Martin, Rm, Martynov, Dv, Massinger, Tj, Mccann, Jj, Mcclelland, De, Mcguire, Sc, Mcmanus, Dj, Mcwilliams, St, Meadors, Gd, Mehta, Ak, Mercer, Ra, Merilh, El, Meyers, Pm, Mikhailov, Ee, Miller, Al, Mills, Jc, Milovich-Goff, Mc, Mitrofanov, Vp, Mohapatra, Srp, Moore, Cj, Mow-Lowry, Cm, Muniz, Ea, Murray, Pg, Nayak, Rk, Nelson, Tjn, Ng, Ky, Nuttall, Lk, O'Brien, Bd, O'Dea, Gd, Ogin, Gh, Oh, Jj, Oh, Sh, Okada, Ma, Oram, Rj, Ormiston, Rg, Ortega, Lf, Ottaway, Dj, Owen, Bj, Pace, Ae, Page, Ma, Pai, Sa, Palamos, Jr, Pan, Hw, Pang, Pth, Pant, Bc, Pearlstone, Bl, Perez, Cj, Pfeiffer, Hp, Piccinni, Oj, Pong, Dyt, Porter, Ek, Prajapati, Ak, Prodi, Ga, Prokhorov, Lg, Purrer, M, Quinonez, Pj, Quintero, Ea, Raab, Fj, Ramirez, Ke, Reitze, Dh, Richardson, Cj, Richardson, Jw, Ricker, Pm, Robertson, Na, Rollins, Jg, Roma, Vj, Romel, Cl, Romie, Jh, Rosinska, D, Rosofsky, Sg, Ross, Mp, Rudiger, A, Sanchez, Ej, Sanchez, Le, Sanders, Jr, Santiago, Ka, Saulson, Pr, Savage, Rl, Schofield, Rm, Schonbeck, A, Schulte, Bw, Schutz, Bf, Schwalbe, Sg, Scott, Sm, Shaddock, Da, Shaner, Mb, Shoemaker, Dh, Shoemaker, Dm, Silva, Ad, Singer, Lp, Sintes, Am, Slagmolen, Bjj, Slaven-Blair, Tj, Smith, Jr, Smith, Rje, Son, Ej, Spencer, Ap, Srivastava, Ak, Steer, Da, Stevenson, Sp, Stops, Dj, Strain, Ka, Strigin, Se, Stuver, Al, Summerscales, Tz, Sutton, Pj, Swinkels, Bl, Szczepanczyk, Mj, Tait, Sc, Tanner, Db, Tapai, M, Tasson, Jd, Thondapu, Sr, Thorne, Ka, Torres-Forne, A, Torrie, Ci, Toyra, D, Tringali, Mc, Tsang, Kw, Urban, Al, Usman, Sa, van Bakel, N, van Beuzekom, M, van den Brand, Jfj, Van Den Broeck, C, Vander-Hyde, Dc, van der Schaaf, L, van Heijningen, Jv, van Veggel, Aa, Vasuth, M, Veitch, Pj, Vicere, A, Viets, Ad, Vine, Dj, Vinet, Jy, Vyatchanin, Sp, Wade, Ar, Wade, Le, Wang, Jz, Wang, Wh, Wang, Yf, Ward, Rl, Warden, Za, Wei, Lw, Weinstein, Aj, Wessel, Ek, Wessels, P, Westhouse, Jw, Whelan, Jt, Whiting, Bf, Wilken, Dm, Williamson, Ar, Willis, Jl, Wimmer, Mh, Wipf, Cc, Wofford, Jk, Wright, Jl, Wysocki, Dm, Yancey, Cc, Yap, Mj, Yeeles, Dw, Yu, Hc, Yuen, Shr, Zadrozny, Ak, Zendri, Jp, Zhu, Xj, Zucker, Me, Physics, Faculty of Sciences and Bioengineering Sciences, Vriendenkring VUB, Elementary Particle Physics, ITA, USA, GBR, FRA, DEU, ESP, Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Astrofísica, collapse [supernova], neutron star: binary, EVENTS GW150914, Gravitació, 010504 meteorology & atmospheric sciences, neutrino: energy: high, Astronomy, RAY, Binary number, binary [neutron star], Astrophysics, 7. Clean energy, 01 natural sciences, Physical Chemistry, Atomic, IceCube, neutrino, Particle and Plasma Physics, Astronomi, astrofysik och kosmologi, black hole, Astronomy, Astrophysics and Cosmology, LIGO, 010303 astronomy & astrophysics, gravitational wave, ELECTROMAGNETIC SIGNALS, QC, QB, Settore FIS/01, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, [PHYS]Physics [physics], Astrophysics::Instrumentation and Methods for Astrophysics, neutrinos, gravitational waves, 520 Astronomie und zugeordnete Wissenschaften, ddc, observatory, Supernova, astrophysics: density, Physical Sciences, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Astronomy and Astrophysics, Space and Planetary Science, Astronomical and Space Sciences, signature, Physical Chemistry (incl. Structural), supernova: collapse, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astronomy & Astrophysics, Gravitational waves, emission [gravitational radiation], Ones gravitacionals, Coincident, 0103 physical sciences, Gravitational Waves, Neutrinos, LIGO, Virgo, Antares, IceCube, Nuclear, ddc:530, Neutrins, energy: high [neutrino], Neutrinos, STFC, Astrophysique, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Science & Technology, ANTARES, Gravitational wave, Virgo, Organic Chemistry, RCUK, Molecular, Astronomie, Astronomy and Astrophysic, 530 Physik, Sciences de l'espace, Black hole, messenger, Neutron star, Antares, Physics and Astronomy, FISICA APLICADA, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], gravitational radiation: emission, density [astrophysics], ddc:520, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], EMISSION
Abstract: [EN] Astrophysical sources of gravitational waves, such as binary neutron star and black hole mergers or core-collapse supernovae, can drive relativistic outflows, giving rise to non-thermal high-energy emission. High-energy neutrinos are signatures of such outflows. The detection of gravitational waves and high-energy neutrinos from common sources could help establish the connection between the dynamics of the progenitor and the properties of the out¿ow. We searched for associated emission of gravitational waves and high-energy neutrinos from astrophysical transients with minimal assumptions using data from Advanced LIGO from its first observing run O1, and data from the ANTARES and IceCube neutrino observatories from the same time period. We focused on candidate events whose astrophysical origins could not be determined from a single messenger. We found no significant coincident candidate, which we used to constrain the rate density of astrophysical sources dependent on their gravitational-wave and neutrino emission processes., The ANTARES Collaboration acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'energie atomique et aux energies alternatives (CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), Labex OCEVU (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; National Authority for Scientific Research (ANCS), Romania; Ministerio de Economia y Competitividad (MINECO): Plan Estatal de Investigacion (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severo Ochoa Centre of Excellence and MultiDark Consolider (MINECO), and Prometeo and Grisolia programs (Generalitat Valenciana), Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities. The IceCube Collaboration gratefully acknowledges the following support: USA-U.S. National Science Foundation-Office of Polar Programs, U.S. National Science Foundation-Physics Division, Wisconsin Alumni Research Foundation, Center for High Throughput Computing (CHTC) at the University of Wisconsin-Madison, Open Science Grid (OSG), Extreme Science and Engineering Discovery Environment (XSEDE), U.S. Department of Energy-National Energy Research Scientific Computing Center, Particle astrophysics research computing center at the University of Maryland, Institute for Cyber-Enabled Research at Michigan State University, and Astroparticle physics computational facility at Marquette University; Belgium-Funds for Scientific Research (FRS-FNRS and FWO), FWO Odysseus and Big Science programmes, and Belgian Federal Science Policy Office (Belspo); Germany-Bundesministerium fur Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), Helmholtz Alliance for Astroparticle Physics (HAP), Initiative and Networking Fund of the Helmholtz Association, Deutsches Elektronen Synchrotron (DESY), and High Performance Computing cluster of the RWTH Aachen; Sweden-Swedish Research Council, Swedish Polar Research Secretariat, Swedish National Infrastructure for Computing (SNIC), and Knut and Alice Wallenberg Foundation; Australia-Australian Research Council; Canada-Natural Sciences and Engineering Research Council of Canada, Calcul Quebec, Compute Ontario, Canada Foundation for Innovation, WestGrid, and Compute Canada; Denmark-Villum Fonden, Danish National Research Foundation (DNRF); New Zealand-Marsden Fund; Japan-Japan Society for Promotion of Science (JSPS) and Institute for Global Prominent Research (IGPR) of Chiba University; Korea-National Research Foundation of Korea (NRF); Switzerland-Swiss National Science Foundation (SNSF). The LIGO Scientific Collaboration and the Virgo Collaboration gratefully acknowledge the support of the United States National Science Foundation (NSF) for the construction and operation of the LIGO Laboratory and Advanced LIGO as well as the Science and Technology Facilities Council (STFC) of the United Kingdom, the Max-Planck-Society (MPS), and the State of Niedersachsen/Germany for support of the construction of Advanced LIGO and construction and operation of the GEO600 detector. Additional support for Advanced LIGO was provided by the Australian Research Council, etc.
Published: 2019

32. Factors associated with morbidity and mortality outcomes following first cranioplasty

Author: Mustafa, M.A., Millward, C.P., Doherty, J., Islim, A.I., Humphries, T., Gillespie, C.S., Richardson, G.E., Keshwara, S.M., Kolamunnage-Dona, R., Broadbelt, A.R., Jenkinson, M.D., Duncan, C., Sinha, A., and McMahon, C.J.
Published: 2021
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33. A host beetle pheromone regulates development and behavior in the nematode Pristionchus pacificus

Author: Jessica K Cinkornpumin, Dona R Wisidagama, Veronika Rapoport, James L Go, Christoph Dieterich, Xiaoyue Wang, Ralf J Sommer, and Ray L Hong
Subjects: Pristionchus pacificus, necromeny, insect pheromone, lipid-binding protein, chemosensation, nematode, Medicine, Science, Biology (General), QH301-705.5
Abstract: Nematodes and insects are the two most speciose animal phyla and nematode–insect associations encompass widespread biological interactions. To dissect the chemical signals and the genes mediating this association, we investigated the effect of an oriental beetle sex pheromone on the development and behavior of the nematode Pristionchus pacificus. We found that while the beetle pheromone is attractive to P. pacificus adults, the pheromone arrests embryo development, paralyzes J2 larva, and inhibits exit of dauer larvae. To uncover the mechanism that regulates insect pheromone sensitivity, a newly identified mutant, Ppa-obi-1, is used to reveal the molecular links between altered attraction towards the beetle pheromone, as well as hypersensitivity to its paralyzing effects. Ppa-obi-1 encodes lipid-binding domains and reaches its highest expression in various cell types, including the amphid neuron sheath and excretory cells. Our data suggest that the beetle host pheromone may be a species-specific volatile synomone that co-evolved with necromeny.
Published: 2014
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34. Developing a laboratory-based score to predict mortality in patients admitted to the ICU

Author: Iqbal, A, Welters, I, Kolamunnage-Dona, R, Toh, C, and Downey, C
Published: 2015
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35. Behavior Associated with the Water Absorption Response by the Toad, Bufo punctatus

Author: Brekke, Dona R., Hillyard, Stanley D., and Winokur, Robert M.
Published: 1991
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36. Self-limited myocarditis presenting with chest pain and ST segment elevation in adolescents after vaccination with the BNT162b2 mRNA vaccine

Author: Park, Jihyun, primary, Brekke, Dona R., additional, and Bratincsak, Andras, additional
Published: 2021
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37. Force-displacement analysis of PMMA/zircon composites using dynamic mechanical analyzer (DMA)

Author: Hilmi, A R, primary, Dona, R, additional, Purnamasari, N D, additional, Wulandari, W, additional, Fauziyah, N A, additional, and Pratapa, S, additional
Published: 2021
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38. Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells

Author: Zhang, Jin, Nuebel, Esther, Wisidagama, Dona R R, Setoguchi, Kiyoko, Hong, Jason S, Van Horn, Christine M, Imam, Sarah S, Vergnes, Laurent, Malone, Cindy S, Koehler, Carla M, and Teitell, Michael A
Published: 2012
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39. The Search for Neutrinos from TXS 0506+056 with the ANTARES Telescope

Author: Albert A, Andre M, Anghinolfi M, Anton G, Ardid M, Aubert JJ, Aublin J, Avgitas T, Baret B, Barrios-Marti J, Basa S, Belhorma B, Benin V, Biagi S, Bormuth R, Boumaaza J, Bourret S, Bouwhuis MC, Branzas H, Bruijn R, Brunner J, Busto J, Capone A, Caramete L, Carr J, Celli S, Chabab M, El Moursli RC, Chiarusi T, Circella M, Coelho JAB, Coleiro A, Colomer M, Coniglione R, Costantini H, Coyle P, Creusot A, Diaz AF, Deschamps A, Distefano C, Di Palma I, Domi A, Dona R, Donzaud C, Dornic D, Drouhin D, Eberl T, El Bojaddaini I, El Khayati N, Elsasser D, Enzenhofer A, Ettahiri A, Fassi F, Felis I, Fermani P, Ferrara G, Fusco L, Gay P, Glotin H, Gregoire T, Ruiz TG, Graf K, Hallmann S, van Haren H, Heijboer AJ, Hello Y, Hernandez-Rey J, Hossl J, Hofestadt J, Illuminati G, de Jong M, Jongen M, Kadler M, Kalekin O, Katz U, Khan-Chowdhury NR, Kouchner A, Kreter M, Kreykenbohm I, Kulikovskiy V, Lachaud C, Lahmann R, Lefevre D, Leonora E, Lotze M, Loucatos S, Marcelin M, Margiotta A, Marinelli A, Martinez-Mora JA, Mele R, Melis K, Migliozzi P, Moussa A, Navas S, Nezri E, Nunez A, Organokov M, Pavalas GE, Pellegrino C, Piattelli P, Popa V, Pradier T, Quinn L, Racca C, Randazzo N, Riccobene G, Sanchez-Losa A, Saldana M, Salvadori I, Samtleben DFE, Sanguineti M, Sapienza P, Schussler F, Spurio M, Stolarczyk T, Taiuti M, Tayalati Y, Trovato A, Vallage B, Van Elewyck V, Versari F, Vivolo D, Wilms J, Zaborov D, Zornoza JD, Zuniga J, Albert, A, Andre, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, Jj, Aublin, J, Avgitas, T, Baret, B, Barrios-Marti, J, Basa, S, Belhorma, B, Benin, V, Biagi, S, Bormuth, R, Boumaaza, J, Bourret, S, Bouwhuis, Mc, Branzas, H, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chabab, M, El Moursli, Rc, Chiarusi, T, Circella, M, Coelho, Jab, Coleiro, A, Colomer, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Diaz, Af, Deschamps, A, Distefano, C, Di Palma, I, Domi, A, Dona, R, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, El Bojaddaini, I, El Khayati, N, Elsasser, D, Enzenhofer, A, Ettahiri, A, Fassi, F, Felis, I, Fermani, P, Ferrara, G, Fusco, L, Gay, P, Glotin, H, Gregoire, T, Ruiz, Tg, Graf, K, Hallmann, S, van Haren, H, Heijboer, Aj, Hello, Y, Hernandez-Rey, J, Hossl, J, Hofestadt, J, Illuminati, G, de Jong, M, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Khan-Chowdhury, Nr, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lachaud, C, Lahmann, R, Lefevre, D, Leonora, E, Lotze, M, Loucatos, S, Marcelin, M, Margiotta, A, Marinelli, A, Martinez-Mora, Ja, Mele, R, Melis, K, Migliozzi, P, Moussa, A, Navas, S, Nezri, E, Nunez, A, Organokov, M, Pavalas, Ge, Pellegrino, C, Piattelli, P, Popa, V, Pradier, T, Quinn, L, Racca, C, Randazzo, N, Riccobene, G, Sanchez-Losa, A, Saldana, M, Salvadori, I, Samtleben, Dfe, Sanguineti, M, Sapienza, P, Schussler, F, Spurio, M, Stolarczyk, T, Taiuti, M, Tayalati, Y, Trovato, A, Vallage, B, Van Elewyck, V, Versari, F, Vivolo, D, Wilms, J, Zaborov, D, Zornoza, Jd, Zuniga, J, KM3NeT (IHEF, IoP, FNWI), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Groupe de Recherche en Physique des Hautes Energies (GRPHE), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), ANTARES, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut Universitaire de Technologie de Colmar, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de Technologie de Colmar-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Albert, A., Andre, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Aublin, J., Avgitas, T., Baret, B., Barrios-Marti, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouwhuis, M. C., Branzas, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., El Moursli, R. C., Chiarusi, T., Circella, M., Coelho, J. A. B., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Diaz, A. F., Deschamps, A., Distefano, C., Palma, I. D., Domi, A., Dona, R., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. E., Khayati, N. E., Elsasser, D., Enzenhofer, A., Ettahiri, A., Fassi, F., Felis, I., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Gregoire, T., Ruiz, R. G., Graf, K., Hallmann, S., Haren, H. V., Heijboer, A. J., Hello, Y., Hernandez-Rey, J. J., Hossl, J., Hofestadt, J., Illuminati, G., Jong, M. D., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Lahmann, R., Lefevre, D., Leonora, E., Lotze, M., Loucatos, S., Marcelin, M., Margiotta, A., Marinelli, A., Martinez-Mora, J. A., Mele, R., Melis, K., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Nunez, A., Organokov, M., Pavalas, G. E., Pellegrino, C., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Randazzo, N., Riccobene, G., Sanchez-Losa, A., Saldana, M., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schussler, F., Spurio, M., Stolarczyk, T., Taiuti, M., Tayalati, Y., Trovato, A., Vallage, B., Elewyck, V. V., Versari, F., Vivolo, D., Wilms, J., Zaborov, D., Zornoza, J. D., Zuniga, J., Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN)-Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD), André, M., Aubert, J.-J., Barrios-Martí, J., Brânzaş, H., El Moursli, R. Cherkaoui, Díaz, A. F., Palma, I. Di, Donà, R., Bojaddaini, I. El, Khayati, N. El, Elsässer, D., Enzenhöfer, A., Grégoire, T., Ruiz, R. Gracia, Haren, H. van, Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Jong, M. de, Lefèvre, D., Martínez-Mora, J. A., Nuñez, A., Păvălaş, G. E., Sánchez-Losa, A., Saldaña, M., Schüssler, F., Stolarczyk, Th., Elewyck, V. Van, Zúñiga, J., Centre Tecnològic de Vilanova i la Geltrú, and Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques
Subjects: Astrofísica, astroparticle physics, elementary particles, galaxies: active, Astronomy and Astrophysics, Space and Planetary Science, FOS: Physical sciences, Library science, astro-ph.HE, Astrophysics, 01 natural sciences, National authority, IceCube, Marie curie, Bildung, astroparticle physics – elementary particles – galaxies: active, 0103 physical sciences, elementary particle, Neutrins, Neutrinos, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, ANTARES, Telescopis, 010308 nuclear & particles physics, Elementary particles, astroparticle physic, neutrino: detector, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], FISICA APLICADA, active [galaxies], time dependence, Christian ministry, Russian federation, galaxy, Astroparticle physics, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], on-line, Telescopes
Abstract: [EN] The results of three different searches for neutrino candidates, associated with the IceCube-170922A event or from the direction of TXS 0506+056, by the ANTARES neutrino telescope, are presented. The ¿rst search refers to the online follow-up of the IceCube alert; the second is based on the standard time-integrated method employed by the Collaboration to search for point-like neutrino sources; the third uses information from the IceCube time-dependent analysis that reported bursting activity centered on 2014 December 13, as input for an ANTARES time-dependent analysis. The online follow-up and the time-dependent analysis yield no events related to the source. The time-integrated study performed over a period from 2007 to 2017 ¿ts 1.03 signal events, which corresponds to a p-value of 3.4% (not considering trial factors). Only for two other astrophysical objects in our candidate list has a smaller p-value been found. When considering that 107 sources have been investigated, the post-trial p-value for TXS 0506+056 corresponds to 87%., We thank the IceCube Collaboration for sharing information before the public release. The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'energie atomique et aux energies alternatives (CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), Labex OCEVU (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; National Authority for Scientific Research (ANCS), Romania; Ministerio de Economia y Competitividad (MINECO): Plan Estatal de Investigacion (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severo Ochoa Centre of Excellence and MultiDark Consolider (MINECO), and Prometeo and Grisolia programs (Generalitat Valenciana), Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM, and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities.
Published: 2018

40. TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]):An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy

Author: Pushpakom, S., Kolamunnage-Dona, R., Taylor, C., Foster, T., Spowart, C., García-Fiñana, M., Kemp, G.J., Jaki, T., Khoo, S., Williamson, P., Pirmohamed, M., Pushpakom, S., Kolamunnage-Dona, R., Taylor, C., Foster, T., Spowart, C., García-Fiñana, M., Kemp, G.J., Jaki, T., Khoo, S., Williamson, P., and Pirmohamed, M.
Abstract: Background Combination antiretroviral therapy results in metabolic abnormalities which increase cardiovascular disease risk. We evaluated whether telmisartan reduces insulin resistance in human immunodeficiency virus (HIV)–positive individuals on antiretrovirals. Methods We conducted a multicenter, randomized, open-label, dose-ranging controlled trial of telmisartan. Participants with HIV infection receiving combination antiretroviral therapy were randomized equally to either no intervention (control) or 20, 40, or 80 mg telmisartan once daily. The adaptive design allowed testing of all dose(s) of telmisartan in stage I, with the promising dose(s) being taken into stage II. The primary outcome measure was reduction in homeostasis model assessment of insulin resistance (HOMA-IR) at 24 weeks. Results A total of 377 patients were recruited. In stage I, 48, 49, 47, and 45 patients were randomized to control and 20, 40, and 80 mg telmisartan, respectively (total n = 189). At the interim analysis, 80 mg telmisartan was taken forward into stage II. At the end of stage II (n = 105, control; 106, 80-mg arm), there were no differences in HOMA-IR (estimated effect, 0.007; SE, 0.106) at 24 weeks between the telmisartan (80 mg) and nonintervention arms. Longitudinal analysis over 48 weeks showed no change in HOMA-IR, lipid or adipokine levels. There were significant (P ≤ .05), but marginal, improvements in revised Quantitative Insulin Sensitivity Check Index (QUICKI) (0.004) and plasma hs-CRP (−0.222 mg/L) and reduction in liver fat content (1.714 mean reduction; P = .005). Conclusions No significant effect of telmisartan was demonstrated on the primary outcome (HOMA-IR), but there were marginal improvements with some secondary outcome measures. Further studies in this population are warranted to identify novel strategies for preventing cardiovascular morbidity and mortality.
Published: 2020

41. Depressive and manic symptoms are not opposite poles in bipolar disorder

Author: Johnson, S. L., Morriss, R., Scott, J., Paykel, E., Kinderman, P., Kolamunnage-Dona, R., and Bentall, R. P.
Published: 2011
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42. Biomarker-guided trials: Challenges in practice

Author: Antoniou, M., primary, Kolamunnage-Dona, R., additional, Wason, J., additional, Bathia, R., additional, Billingham, C., additional, Bliss, J.M., additional, Brown, L.C., additional, Gillman, A., additional, Paul, J., additional, and Jorgensen, A.L., additional
Published: 2019
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43. Enhanced relapse prevention for bipolar disorder by community mental health teams: cluster feasibility randomised trial

Author: Lobban, F., Taylor, L., Chandler, C., Tyler, E., Kinderman, P., Kolamunnage-Dona, R., Gamble, C., Peters, S., Pontin, E., Sellwood, W., and Morriss, R. K.
Published: 2010
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44. Time-scale and excitation energy partition in sequential binary decays induced by heavy-ion collisions at ≃6 MeV·A

Author: Boccaccio, P., Vannucci, L., Ricci, R.A., Vannini, G., Dona, R., Massa, I., Coffin, J.P., Fintz, P., Guillaume, G., Jundt, F., Rami, F., and Wagner, P.
Published: 1998
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45. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

Author: Dona R. Wisidagama, William E. Lowry, James E. Cox, Kristofor A. Olson, Jason M. Tanner, Helong Zhao, Peng Wei, T. Cameron Waller, John C. Schell, Jared Rutter, Lei Jiang, Carl S. Thummel, Priyanka Kanth, Lise K. Sorensen, Christian S. Earl, Claire L. Bensard, Dean Y. Li, Don A. Delker, Ren Miao, Aimee Flores, Heather R. Christofk, Jeffrey Mohlman, Ralph J. DeBerardinis, and Mary P. Bronner
Subjects: 0301 basic medicine, Time Factors, Cellular differentiation, Mitochondrion, Mitochondrial Membrane Transport Proteins, Medical and Health Sciences, Receptors, G-Protein-Coupled, Tissue Culture Techniques, Mice, chemistry.chemical_compound, immune system diseases, Pyruvic Acid, Receptors, Drosophila Proteins, Glycolysis, Intestinal Mucosa, Cells, Cultured, Mice, Knockout, Cultured, Stem Cells, Cell Differentiation, Biological Sciences, Mitochondria, Cell biology, Intestines, Drosophila melanogaster, Phenotype, Acrylates, Biochemistry, RNA Interference, Stem cell, Signal Transduction, Monocarboxylic Acid Transporters, Pyruvate decarboxylation, Pyruvate dehydrogenase kinase, Genotype, Cells, Knockout, Anion Transport Proteins, PKM2, Biology, Transfection, Article, Mitochondrial Proteins, G-Protein-Coupled, 03 medical and health sciences, Animals, Humans, Lactic Acid, Cell Proliferation, Cell Biology, 030104 developmental biology, chemistry, Pyruvic acid, Developmental Biology
Abstract: Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient mitochondrial pyruvate uptake. In contrast, proliferative cells, including many cancer and stem cells, perform glycolysis robustly but limit fractional mitochondrial pyruvate oxidation. We sought to understand the role this transition from glycolysis to pyruvate oxidation plays in stem cell maintenance and differentiation. Loss of the MPC in Lgr5-EGFP-positive stem cells, or treatment of intestinal organoids with an MPC inhibitor, increases proliferation and expands the stem cell compartment. Similarly, genetic deletion of the MPC in Drosophila intestinal stem cells also increases proliferation, whereas MPC overexpression suppresses stem cell proliferation. These data demonstrate that limiting mitochondrial pyruvate metabolism is necessary and sufficient to maintain the proliferation of intestinal stem cells.
Published: 2017

46. Self-limited myocarditis presenting with chest pain and ST segment elevation in adolescents after vaccination with the BNT162b2 mRNA vaccine.

Author: Park, Jihyun, Brekke, Dona R., and Bratincsak, Andras
Published: 2022
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47. Clustering in dissipative ternary processes induced in medium-mass systems

Author: Vannucci, L., Boccaccio, P., Ricci, R. A., Vannini, G., Dona, R., Massa, I., Coffin, J. P., Fintz, P., Giullaume, G., Jundt, F., Rami, F., and Wagner, P.
Published: 1997
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48. Regulation of

Author: Dona R, Wisidagama and Carl S, Thummel
Subjects: Monocarboxylic Acid Transporters, Stem Cells, fungi, Anion Transport Proteins, Cell Differentiation, intestinal homeostasis, Investigations, Mitochondria, Intestines, Enterocytes, Animals, Drosophila Proteins, Drosophila, Female, Pyruvates, metabolism, Cell Proliferation
Abstract: Multiple signaling pathways in the adult Drosophila enterocyte sense cellular damage or stress and signal to intestinal stem cells (ISCs) to undergo proliferation and differentiation, thereby maintaining intestinal homeostasis. Here we show that misregulation of mitochondrial pyruvate metabolism in enterocytes can stimulate ISC proliferation and differentiation. Our studies focus on the Mitochondrial Pyruvate Carrier (MPC), which is an evolutionarily-conserved protein complex that resides in the inner mitochondrial membrane and transports cytoplasmic pyruvate into the mitochondrial matrix. Loss of MPC function in enterocytes induces Unpaired cytokine expression, which activates the JAK/STAT pathway in ISCs, promoting their proliferation. Upd3 and JNK signaling are required in enterocytes for ISC proliferation, indicating that this reflects a canonical non-cell autonomous damage response. Disruption of lactate dehydrogenase in enterocytes has no effect on ISC proliferation but it suppresses the proliferative response to a loss of enterocyte MPC function, suggesting that lactate contributes to this pathway. These studies define an important role for cellular pyruvate metabolism in differentiated enterocytes to maintain stem cell proliferation rates.
Published: 2019

49. Functional analysis of Aarf domain-containing kinase 1 in Drosophila melanogaster

Author: Geanette Lam, Carl S. Thummel, Dona R. Wisidagama, and Stefan M. Thomas
Subjects: 0301 basic medicine, Ecdysone, Mutant, Longevity, Context (language use), Article, Mitochondrial Proteins, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, RNA interference, Animals, Drosophila Proteins, Abnormalities, Multiple, Gene, Caenorhabditis elegans, biology, Kinase, fungi, biology.organism_classification, Cell biology, Trachea, 030104 developmental biology, Drosophila melanogaster, chemistry, Larva, Mutant Proteins, Protein Kinases, 030217 neurology & neurosurgery, Developmental Biology
Abstract: BACKGROUND: The ADCK proteins are predicted mitochondrial kinases. Most studies of these proteins have focused on the Abc1/Coq8 subfamily, which contributes to Coenzyme Q biosynthesis. In contrast, little is known about ADCK1 despite its evolutionary conservation in yeast, Drosophila, Caenorhabditis elegans and mammals. RESULTS: We show that Drosophila ADCK1 mutants die as second instar larvae with double mouth hooks and tracheal breaks. Tissue-specific genetic rescue and RNAi studies show that ADCK1 is necessary and sufficient in the trachea for larval viability. In addition, tracheal-rescued ADCK1 mutant adults have reduced lifespan, are developmentally delayed, have reduced body size, and normal levels of basic metabolites. CONCLUSION: The larval lethality and double mouth hooks seen in ADCK1 mutants are often associated with reduced levels of the steroid hormone ecdysone, suggesting that this gene could contribute to controlling ecdysone levels or bioavailability. Similarly, the tracheal defects in these animals could arise from defects in intracellular lipid trafficking. These studies of ADCK1 provide a new context to define the physiological functions of this poorly understood member of the ADCK family of predicted mitochondrial proteins.
Published: 2019

50. Search for multimessenger sources of gravitational waves and high-energy neutrinos with advanced LIGO during Its first observing run, ANTARES, and IceCube

Author: Albert, A., Andre, M., Anghinolfi, M., Ardid, M., Aubert, J. J., Aublin, J., Avgitas, T., Baret, B., Barrios-Marti, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Boumaaza, J., Bourret, S., Bouwhuis, M. C., Branzas, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chabab, M., El Moursli, R. C., Chiarusi, T., Circella, M., Coelho, J. A. B., Coleiro, A., Colomer, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Diaz, A. F., Deschamps, A., Distefano, C., Di Palma, I., Domi, A., Dona, R., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., El Bojaddaini, I., El Khayati, N., Elsasser, D., Enzenhofer, A., Ettahiri, A., Fassi, F., Felis, I., Fermani, P., Ferrara, G., Fusco, L., Gay, P., Glotin, H., Gregoire, T., Ruiz, R. G., Graf, K., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Yann, ANTARES Collaboration, IceCube Collaboration, LIGO Scientific Collaboration, and Virgo Collaboration
Subjects: gravitational waves, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, neutrinos, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics::Galaxy Astrophysics
Abstract: Astrophysical sources of gravitational waves, such as binary neutron star and black hole mergers or core-collapse supernovae, can drive relativistic outflows, giving rise to non-thermal high-energy emission. High-energy neutrinos are signatures of such outflows. The detection of gravitational waves and high-energy neutrinos from common sources could help establish the connection between the dynamics of the progenitor and the properties of the outflow. We searched for associated emission of gravitational waves and high-energy neutrinos from astrophysical transients with minimal assumptions using data from Advanced LIGO from its first observing run O1, and data from the ANTARES and IceCube neutrino observatories from the same time period. We focused on candidate events whose astrophysical origins could not be determined from a single messenger. We found no significant coincident candidate, which we used to constrain the rate density of astrophysical sources dependent on their gravitational-wave and neutrino emission processes.
Published: 2019

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