42 results on '"Domoto H"'
Search Results
2. Mucinous cystadenocarcinoma of the breast showing sulfomucin production
- Author
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Domoto, H, Terahata, S, Yamazaki, T, Sato, K, Takeo, H, and Tamai, S
- Published
- 2000
3. Clear cell change in colorectal adenomas: its incidence and histological characteristics
- Author
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Domoto, H, Terahata, S, Senoh, A, Sato, K, Aida, S, and Tamai, S
- Published
- 1999
4. Global supply chains: Gaining from vertical partnerships
- Author
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Kotabe, M., Martin, Xavier, Domoto, H., Mol, M.J., Research Group: Organization, and Department of Management
- Published
- 2005
5. Maintenance support systems using a network technique of programmable controllers
- Author
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Domoto, H., primary, Iwamoto, T., additional, Moriyama, K., additional, and Nakao, S., additional
- Published
- 1997
- Full Text
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6. Determination of plasma phenobarbital concentration by high-performance liquid chromatography in rat offspring
- Author
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Moriyama, M., Yamashita, S., Domoto, H., Funtoo, K., Araki, H., and Gornita, Y.
- Published
- 1999
- Full Text
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7. Supply chains
- Author
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Kotabe, M., Xavier Martin, Domoto, H., Research Group: Organization, and Department of Management
8. An alkaloid and two lignans from Cuscuta chinensis
- Author
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Yahara, S., Domoto, H., Sugimura, C., and Nohara, T.
- Published
- 1994
- Full Text
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9. CDX2-positive Cancer of Unknown Primary With Upper-body Paralysis Was Dramatically Improved by Colorectal Cancer Chemotherapy.
- Author
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Akagi H, Tanaka Y, Wada K, Takahashi M, Yoshida K, and Domoto H
- Subjects
- Humans, Female, Middle Aged, Homeodomain Proteins, CDX2 Transcription Factor, Biomarkers, Tumor, Neoplasms, Unknown Primary, Colorectal Neoplasms pathology, Adenocarcinoma pathology
- Abstract
Background: Caudal-related homeobox transcription factor 2 (CDX2) is expressed in intestinal epithelial cells. CDX2 is a very sensitive marker for the identification of small and large intestine tumors, which is expressed in 85.7-100% of colorectal cancer (CRC) cases., Case Report: A 61-year-old female had been suffering from left shoulder pain for one month. Computed tomography showed osteolytic masses extending to the vertebral arch in the C5, C6, C7, and Th3 vertebral bodies. In addition, a thickening of the sigmoid colon was observed from the rectal-sigmoid colon, suggesting CRC. A colon biopsy revealed poorly differentiated adenocarcinoma and the vertebra excision was metastatic adenocarcinoma. However, immunohistochemically, the vertebra tumor was negative for CK7 and CK20 but positive for CDX2. Therefore, we made the diagnosis of CRC with bone metastasis and decided to start treatment for CRC. Posterior stabilization was performed for the spinal tumor 6 days after admission. About one month after admission, she started treatment with chemotherapy. Initially, her left hand could not move, and she could barely hold the pen with her right hand. After adding cetuximab for the third time, she became able to bend the dorsiflexion of her right wrist joint, grasp a stick with her right hand, and move the fingertips of her left hand a little., Conclusion: The presented case could not be diagnosed as CRC unless CDX2 was examined. Upper body paralysis due to CRC bone metastasis was improved by chemotherapy., (Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2023
- Full Text
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10. Evaluation of Data-Driven Respiration Gating in Continuous Bed Motion in Lung Lesions.
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Nii T, Hosokawa S, Kotani T, Domoto H, Nakamura Y, Tanada Y, Kondo R, and Takahashi Y
- Subjects
- Humans, Positron Emission Tomography Computed Tomography, Respiration, Positron-Emission Tomography methods, Lung, Motion, Fluorodeoxyglucose F18, Lung Neoplasms, Respiratory-Gated Imaging Techniques methods
- Abstract
Respiration gating is used in PET to prevent image quality degradation due to respiratory effects. In this study, we evaluated a type of data-driven respiration gating for continuous bed motion, OncoFreeze AI, which was implemented to improve image quality and the accuracy of semiquantitative uptake values affected by respiratory motion. Methods:
18 F-FDG PET/CT was performed on 32 patients with lung lesions. Two types of respiration-gated images (OncoFreeze AI with data-driven respiration gating, device-based amplitude-based OncoFreeze with elastic motion compensation) and ungated images (static) were reconstructed. For each image, we calculated SUV and metabolic tumor volume (MTV). The improvement rate (IR) from respiration gating and the contrast-to-noise ratio (CNR), which indicates the improvement in image noise, were also calculated for these indices. IR was also calculated for the upper and lower lobes of the lung. As OncoFreeze AI assumes the presence of respiratory motion, we examined quantitative accuracy in regions where respiratory motion was not present using a68 Ge cylinder phantom with known quantitative accuracy. Results: OncoFreeze and OncoFreeze AI showed similar values, with a significant increase in SUV and decrease in MTV compared with static reconstruction. OncoFreeze and OncoFreeze AI also showed similar values for IR and CNR. OncoFreeze AI increased SUVmax by an average of 18% and decreased MTV by an average of 25% compared with static reconstruction. From the IR results, both OncoFreeze and OncoFreeze AI showed a greater IR from static reconstruction in the lower lobe than in the upper lobe. OncoFreeze and OncoFreeze AI increased CNR by 17.9% and 18.0%, respectively, compared with static reconstruction. The quantitative accuracy of the68 Ge phantom, assuming a region of no respiratory motion, was almost equal for the static reconstruction and OncoFreeze AI. Conclusion: OncoFreeze AI improved the influence of respiratory motion in the assessment of lung lesion uptake to a level comparable to that of the previously launched OncoFreeze. OncoFreeze AI provides more accurate imaging with significantly larger SUVs and smaller MTVs than static reconstruction., (© 2023 by the Society of Nuclear Medicine and Molecular Imaging.)- Published
- 2023
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11. Surface CD3-negative monomorphic epitheliotropic intestinal T-cell lymphoma.
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Domoto H, Araki T, Ogai A, Inukai M, Chen CK, Tomita S, Mukai K, and Nakamura N
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- Female, Granzymes, Humans, Immunohistochemistry, Middle Aged, Perforin, Enteropathy-Associated T-Cell Lymphoma diagnosis, Enteropathy-Associated T-Cell Lymphoma genetics, Lymphoma, Extranodal NK-T-Cell pathology
- Abstract
Intestinal T/NK-cell lymphomas include enteropathy-associated T-cell lymphoma (EATL), monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), indolent T-cell lymphoproliferative disorders of the GI tract (ITCLPD), extranodal NK/T-cell lymphoma, nasal type (ENKTL), and intestinal T-cell lymphoma NOS (ITCL-NOS). Here we describe a case of surface CD3-negative MEITL. A 63-year-old Japanese female had a tumor located in the conglomerated ileum, which formed multiple mass lesions. The resected tissue showed a diffuse infiltration of monomorphic medium-sized lymphocytes with epitheliotropism. Flowcytometry using a fresh specimen of the tumor revealed positivity for CD7, CD8, CD38, and CD56, but not surface CD3. On immunohistochemistry, the tumor showed positivity for cytoplasmic CD3, CD8, CD56, TIA-1, Granzyme B, and perforin. EBER with in situ hybridization was negative. Moreover, H3K36me3, which is negative in MEITL with SETD2-mutation, was positive. This is an important case of MEITL due to its oncogenesis.
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- 2022
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12. Fatal Disseminated Tuberculosis and Concurrent Disseminated Cryptococcosis in a Ruxolitinib-treated Patient with Primary Myelofibrosis: A Case Report and Literature Review.
- Author
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Ogai A, Yagi K, Ito F, Domoto H, Shiomi T, and Chin K
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- Aged, Granuloma, Humans, Male, Nitriles, Pyrazoles, Pyrimidines, Cryptococcosis complications, Cryptococcosis diagnosis, Cryptococcosis drug therapy, Primary Myelofibrosis complications, Primary Myelofibrosis drug therapy, Tuberculosis, Miliary
- Abstract
Ruxolitinib, a Janus kinase inhibitor, improves symptoms in patients with myelofibrosis. However, its association with the development of opportunistic infections has been a concern. We herein report a 71-year-old man with primary myelofibrosis who developed disseminated tuberculosis and concurrent disseminated cryptococcosis during ruxolitinib treatment. We also reviewed the literature on disseminated tuberculosis and/or cryptococcosis associated with ruxolitinib treatment. This is the first case of disseminated tuberculosis and concurrent disseminated cryptococcosis during treatment with ruxolitinib. We therefore suggest considering not only disseminated tuberculosis but also cryptococcosis in the differential diagnosis of patients with abnormal pulmonary shadows during ruxolitinib treatment.
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- 2022
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13. [A case of gastric mixed neuroendocrine-non-neuroendocrine neoplasm that developed five years after pancreatic neuroendocrine tumor treatment].
- Author
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Shirakawa C, Mino K, Fukasawa T, Nakatsumi H, Kimura T, Domoto H, and Kawamura H
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- Endoscopy, Gastrointestinal, Humans, Male, Middle Aged, Neuroendocrine Tumors diagnosis, Neuroendocrine Tumors surgery, Pancreatic Neoplasms diagnostic imaging, Pancreatic Neoplasms pathology, Pancreatic Neoplasms surgery, Stomach Neoplasms diagnosis
- Abstract
We present a case of 63-year-old male patient who underwent subtotal stomach-preserving pancreaticoduodenectomy for pancreatic neuroendocrine tumor (NET) G2. He had been followed up for three years and had no signs of recurrence postoperatively. Five years after surgery, he had abdominal pain. Upper gastrointestinal endoscopy showed a gastric tumor. Laparoscopic distal gastrectomy was performed without postoperative complications. The histopathological findings of the resected specimen were consistent with mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN). The immunohistochemical characteristics of the gastric MiNEN lesion were different from those of the pancreatic NET lesion resected five years ago, suggesting that those lesions were heterochronous.
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- 2022
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14. Successful Tepotinib Challenge After Capmatinib-Induced Interstitial Lung Disease in a Patient With Lung Adenocarcinoma Harboring MET Exon 14 Skipping Mutation: Case Report.
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Hashiguchi MH, Sato T, Yamamoto H, Watanabe R, Kagyo J, Domoto H, and Shiomi T
- Abstract
MET tyrosine kinase inhibitors, capmatinib and tepotinib, have been recently introduced for the treatment of advanced NSCLC with MET exon 14 skipping mutations. Although interstitial lung disease (ILD) induced by these drugs is reported, its optimal management and whether they can be rechallenged remain unclear. We report the first successful case of tepotinib treatment after capmatinib-induced ILD. Switching MET tyrosine kinase inhibitors after drug-induced ILD could be a clinical option, which warrants further investigation., (© 2021 The Authors.)
- Published
- 2021
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15. Standard therapy-resistant small cell lung cancer showing dynamic transition of neuroendocrine fate during the cancer trajectory: A case report.
- Author
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Ito F, Sato T, Emoto K, Kaizuka N, Yagi K, Watanabe R, Hashiguchi MH, Ninomiya H, Ikematsu Y, Tanaka K, Domoto H, and Shiomi T
- Abstract
While small cell lung cancer (SCLC) has been treated as a single disease historically, recent studies have suggested that SCLC can be classified into molecular subtypes based on the expression of lineage transcription factors such as achaete-scute homolog 1 (ASCL1), neurogenic differentiation factor 1 (NEUROD1), POU domain class 2 transcription factor 3 (POU2F3) and transcriptional coactivator YAP1 (YAP1). These transcription factor-based subtypes may be specifically targeted in therapy, and recent studies have suggested that the SCLC subtypes represent different stages of dynamic evolution of SCLC rather than independent diseases. Nevertheless, evidence of shift in neuroendocrine differentiation during SCLC evolution has been lacking in the clinical setting. In the present study, a 60-year-old male was diagnosed with extensive SCLC. The tumor responded not to the standard SCLC regimen of carboplatin, etoposide and atezolizumab, but to the non-SCLC regimen of carboplatin, nab-paclitaxel and pembrolizumab. The patient succumbed 5 months after the initial diagnosis and a pathological autopsy was performed. The tumor was originally negative for all four transcription factors, ASCL1, NEUROD1, POU2F3 and YAP1, in the biopsy specimens at diagnosis. Loss of synaptophysin expression and emergence of Myc proto-oncogene protein and YAP1 expression was recorded in the autopsy specimens, suggesting the transition to a decreased neuroendocrine fate during the disease trajectory. This case provides clinical evidence of dynamic transition of neuroendocrine fate during SCLC evolution. In light of SCLC heterogeneity and plasticity, development of precision medicine is required., Competing Interests: Dr Takashi Sato reports personal fees from Chugai Pharmaceutical (Tokyo, Japan) and Bristol Myers Squibb (Tokyo, Japan), outside of the submitted work. Dr Hironori Ninomiya reports personal fees from Merck Sharp and Dohme (Tokyo, Japan) outside the submitted work. Dr Kentaro Tanaka reports grants and personal fees from Chugai Pharmaceutical, and personal fees from Taiho Pharmaceutical (Tokyo, Japan), outside the submitted work. Dr Tetsuya Shiomi reports personal fees from Boehringer Ingelheim (Tokyo, Japan), Bristol Myers Squibb, Chugai Pharmaceutical, Pfizer (Tokyo, Japan) and Taiho Pharmaceutical, outside the submitted work. The remaining authors declare no conflicts of interest., (Copyright © 2020, Spandidos Publications.)
- Published
- 2021
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16. Achievements of true whole-body imaging using a faster acquisition of the lower extremities in variable-speed continuous bed motion.
- Author
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Nii T, Hosokawa S, Shirako K, Nishimura M, Domoto H, Nakamura Y, Tanada Y, Kondo R, and Takahashi Y
- Subjects
- Fluorodeoxyglucose F18, Humans, Lower Extremity diagnostic imaging, Positron-Emission Tomography, Positron Emission Tomography Computed Tomography, Whole Body Imaging
- Abstract
Variable-speed continuous bed motion
18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT), a reliable imaging technique, allows setting the bed motion speed for arbitrary sections of the body. The purpose of this study was to evaluate the relationship between the PET image quality and the bed speed following shortening of the scanning time for the lower extremities to achieve whole-body acquisition optimization of the examination time. Four sets of images were created by editing four-phase dynamic whole-body PET/CT images acquired at a bed speed of 6 and 14 mm/s in the trunk and lower extremities, respectively. The signal-to-noise ratio (SNR) was calculated using regions of interest in the liver, gluteus muscles, thigh, and lower legs, and the relationship between the bed speed and the SNR was assessed. The number of patients with findings in the lower extremities among 967 cases was evaluated. Based on this relationship between the SNR and bed motion speed, it is reasonable to increase the speed of the lower extremities by up to three times that of the trunk. The findings from whole-body FDG-PET imaging revealed that the number of patients with detected lesions in the lower extremities was 6.6% (64/967), bone metastases were found in 2.6%, soft lesions in 1.8%, and inflammation in 2.3%. Images of the lower extremities, which have a better SNR than the trunk, can be acquired at a faster bed speed using the variable-speed continuous bed motion PET., (© 2021. Japanese Society of Radiological Technology and Japan Society of Medical Physics.)- Published
- 2021
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17. A case of lung adenocarcinoma with a novel CD74-ROS1 fusion variant identified by comprehensive genomic profiling that responded to crizotinib and entrectinib.
- Author
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Hashiguchi MH, Sato T, Watanabe R, Kagyo J, Matsuzaki T, Domoto H, Kato T, Nakahara Y, Yokose T, Hiroshima Y, and Shiomi T
- Subjects
- Adenocarcinoma of Lung pathology, Adult, Female, Gene Rearrangement, Humans, Lung Neoplasms pathology, Oncogene Proteins, Fusion genetics, Protein Kinase Inhibitors therapeutic use, Protein-Tyrosine Kinases genetics, Proto-Oncogene Proteins genetics, Adenocarcinoma of Lung drug therapy, Adenocarcinoma of Lung genetics, Benzamides therapeutic use, Crizotinib therapeutic use, Genomics, Indazoles therapeutic use, Lung Neoplasms drug therapy, Lung Neoplasms genetics
- Abstract
ROS1 rearrangements are found in 1-2% of patients with non-small-cell lung cancer. The detection of the rearrangements is crucial since clinically effective molecular targeted drugs are available for them. We present a case of lung adenocarcinoma with a previously unknown ROS1-CD74 fusion variant, CD74 exon 3 fused to ROS1 exon 34, which was not detected by a conventional RT-PCR-based test for ROS1 fusion gene detection but identified by hybrid capture-based next-generation sequencing. This tumor responded to crizotinib initially and to entrectinib after relapse with brain metastasis, indicating the oncogenic activity of this novel fusion variant., (© 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)
- Published
- 2021
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18. Successful Stabilization of Symptomatic Bone Marrow Metastasis Two Times in a Breast Cancer Patient.
- Author
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Akagi H, Shimada A, Chin K, and Domoto H
- Subjects
- Bone Marrow Neoplasms drug therapy, Breast Neoplasms drug therapy, Female, Humans, Middle Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bone Marrow Neoplasms secondary, Breast Neoplasms pathology, Neoplasm Metastasis pathology
- Abstract
Background: Bone marrow metastasis is very uncommon in breast cancer. Cancer patients showing a dramatic response to chemotherapy with full recovery are very rare., Case Report: This is a case report of a 62-year-old woman who underwent partial mastectomy six years previously. The patient presented with increased fatigue and her hemoglobin level was 6.7 g/dl. Pathological examination of a bone marrow biopsy showed metastasis from breast cancer. Systemic therapy was initiated with doxorubicin and cyclophosphamide and pancytopenia was steadily improved. However, 15 months later, she felt severe fatigue again. Eribulin was administered and the patient showed sufficient recovery. She had two bone marrow metastases that caused pancytopenia including severe anemia. However, she survived twice with chemotherapy., Conclusion: Bone marrow metastasis of breast cancer is life-threatening; however, chemotherapy may significantly improve survival., (Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2021
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19. Recurrence after ESD curative resection for early gastric cancer.
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Kamiya A, Katai H, Ishizu K, Wada T, Hayashi T, Otsuki S, Yamagata Y, Yoshikawa T, Sekine S, Nishi T, Kawasaki Y, Ito T, and Domoto H
- Abstract
Background: Endoscopic submucosal dissection (ESD) is gaining ground as a minimally invasive treatment for early gastric cancer (EGC) that has a negligible risk of lymph node metastasis. According to the 5th edition of Japanese gastric cancer treatment guidelines, annual or biannual follow-up with endoscopy is recommended, but follow-up with abdominal ultrasonography or computed tomography (CT) for surveillance of metastases is not recommended after the eCuraA resection. However, we experienced a case of lymph node recurrence following ESD resulting in eCuraA., Case Presentation: A 76-year-old female received ESD for EGC in a previous hospital 4 years ago. Pathological findings were tub1, 30 mm, T1a (M), UL0, Ly0, V0, pHM-, pVM- (eCuraA) according to the 15th edition of Japanese Classification of Gastric Carcinoma. Follow-up esophagogastroduodenoscopy revealed submucosal tumor, which was suspected as a swollen lymph node by CT and endoscopic ultrasound fine-needle aspiration revealed the recurrence of gastric cancer. We performed total gastrectomy with D2 lymph node dissection. Postoperative pathological examination revealed no local recurrent tumor at the ESD site in the stomach. Swollen lymph node was diagnosed as metastasis and lymph node metastasis was limited near the cardia., Conclusion: This case provides valuable information about tumor with a minimum poorly differentiated adenocarcinoma component may develop lymph node metastasis even satisfying the guidelines criteria for curative resection.
- Published
- 2021
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20. [IPSILATERAL SYNCHRONOUS MUCINOUS TUBULAR AND SPINDLE CELL CARCINOMA AND CLEAR CELL PAPILLARY RENAL CELL CARCINOMA: A CASE REPORT AND REVIEW OF THE LITERATURE].
- Author
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Tanigawa M, Huruuchi T, Tamura K, Nakajima F, Domoto H, Mukai K, and Nagashima Y
- Abstract
Renal cell carcinoma (RCC), the most common solid lesion of the kidney, accounts for approximately 2%-3% of all malignancies among adults. Clear cell carcinoma and papillary cell carcinoma are the most common types of renal tumors. Some case reports have described synchronous benign and malignant tumors in the same kidney. In particular, angiomyolipoma and RCC in patients with tuberous sclerosis (TSC) and non-TSC have been reported many times in the literature. However, unilateral concordance of malignant renal tumors is very rare; thus, only few cases have been reported in the literature.Here we report the case of a 58-year-old male who had ipsilateral synchronous mucinous tubular and spindle cell carcinoma (MTSCC) and clear cell papillary renal cell carcinoma (CCPRCC). Both cancers are rare and relatively recently defined subtypes of RCC. Additionally, both were successfully treated using partial nephrectomy. MTSCC has been a distinct entity in the World Health Organization classification of kidney tumors since 2004. The classic type of MTSCC is characterized by small elongated tubules lined with clear cuboidal or spindle cells with mucinous stroma. Neoplastic cells always exhibit low-grade histological features. However, unclassified variants of MTSCC, such as mucin-poor, papillary, high-grade, and sarcomatoid variants, have also been reported. MTSCC is considered to have a relatively good prognosis, but some patients with poor prognoses have recently been reported. CCPRCC is a recently recognized entity and represents the fourth most common variant of RCC. It has unique morphological and immunohistochemical features and shows indolent clinical behavior. Microscopically, CCPRCC may mimic other RCCs with clear cell features, such as clear cell RCC, translocation RCC, and papillary RCC, with clear cell changes. In 2006, CCPRCC was described as a subtype of renal tumors in patients with end-stage renal disease. However, currently, CCPRCC has also been shown to occur in kidneys with normal function.To the best of our knowledge, this is the first report of ipsilateral synchronous MTSCC and CCPRCC, which we present with a review of the pertinent literature.
- Published
- 2020
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21. Invasive Solid Papillary Carcinoma of the Nipple With Pagetoid Extension and Nodal Metastasis.
- Author
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Domoto H, Watanabe A, Sakata M, Shimada A, and Mukai K
- Subjects
- Aged, 80 and over, Axilla, Biopsy, Breast Neoplasms diagnostic imaging, Breast Neoplasms surgery, Carcinoma, Ductal, Breast diagnostic imaging, Carcinoma, Ductal, Breast surgery, Carcinoma, Papillary diagnostic imaging, Carcinoma, Papillary surgery, Female, Humans, Lymph Node Excision, Lymph Nodes pathology, Lymph Nodes surgery, Lymphatic Metastasis, Magnetic Resonance Imaging, Mastectomy, Neoplasm Invasiveness pathology, Nipples diagnostic imaging, Nipples surgery, Paget's Disease, Mammary diagnostic imaging, Paget's Disease, Mammary surgery, Breast Neoplasms pathology, Carcinoma, Ductal, Breast pathology, Carcinoma, Papillary pathology, Nipples pathology, Paget's Disease, Mammary pathology
- Abstract
We report a case of invasive solid papillary carcinoma (SPC) of the nipple with Pagetoid extension to the skin and lymph node metastasis. SPC is an uncommon primary breast cancer accounting for less than 1% of all breast cancers. Only 2 cases occurring in the nipple have been reported. However, both cases were without Pagetoid extension or lymph node metastasis. The presently reported tumor consisted of irregularly shaped solid cell nests with delicate fibrovascular cores. The tumor cells had round nuclei with low-grade atypia and eosinophilic cytoplasm. Neuroendocrine differentiation was confirmed by immunohistochemical positivity for CD56, synaptophysin, and chromogranin A. Immunohistochemistry also confirmed the absence of myoepithelial cells around the tumor cell nests. Therefore, a diagnosis of invasive SPC was made. Additionally, tumor cell deposits in the intramammary and axillary lymph nodes were identified, and these deposits had the same histological characteristics as the invasive SPC of the nipple. The invasiveness of SPC can be difficult to determine. However, the tumor cell nests in the current case exhibited a retraction artifact, which is known to be associated with invasive carcinoma and a poor prognosis, as well as morphological patterns that have been previously identified as characteristic of invasive SPC. Although SPC is widely recognized as having a favorable outcome, the existence of exceptionally aggressive cases occurring in the nipple must be recognized. Additional cases of invasive SPC of the nipple are needed to analyze the clinicopathological correlation.
- Published
- 2018
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22. [Resection of a Granulocyte Colony-Stimulating Factor-Producing Anaplastic Carcinoma of the Pancreas, Associated with Humoral Hypercalcemia of Malignancy].
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Seki H, Yasui N, Shimada A, Matsumoto H, and Domoto H
- Subjects
- Aged, Fatal Outcome, Humans, Liver Neoplasms secondary, Male, Pancreatic Neoplasms pathology, Pancreatic Neoplasms surgery, Pancreaticoduodenectomy, Granulocyte Colony-Stimulating Factor biosynthesis, Hypercalcemia etiology, Pancreatic Neoplasms complications, Paraneoplastic Syndromes etiology
- Abstract
We herein report the case of a 65-year-old man who presented with an anaplastic carcinoma of the pancreas, producing granulocyte colony-stimulating factor (G-CSF). The patient's laboratory data showed an increase in his serum CA19-9 levels 1 year after he had undergone surgery for transverse colon cancer. Computed tomography (CT) showed a mass in the pancreatic head. Following a diagnosis of primary or metastatic pancreatic cancer, we performed the pancreatoduodenectomy. The postoperative course was uneventful. However, on postoperative day 28, he suffered a disturbance of consciousness and demonstrated hypercalcemia with elevated serum levels of parathyroid hormone-related protein (PTHrP). CT revealed multiple liver metastases and massive ascites. His serum Ca level decreased temporarily, and he subsequently died 58 days after the pancreatoduodenectomy. A pathological examination revealed pleomorphic-type anaplastic carcinoma of the pancreas. Immunohistochemical staining showed the tumor cells to be positive for G-CSF. To the best of our knowledge, there have been no reports of G-CSF-producing anaplastic carcinoma of the pancreas associated with humoral hypercalcemia of malignancy.
- Published
- 2018
23. A mass protruding from the pancreas featuring extensive myxoid change.
- Author
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Takahashi H, Ogata S, Domoto H, Oda T, Kawaguchi S, Kato K, Teramura Y, and Nakanishi K
- Published
- 2018
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24. Up-Regulation of Antioxidant Proteins in the Plasma Proteome during Saturation Diving: Unique Coincidence under Hypobaric Hypoxia.
- Author
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Domoto H, Iwaya K, Ikomi F, Matsuo H, Tadano Y, Fujii S, Tachi K, Itoh Y, Sato M, Inoue K, and Shinomiya N
- Subjects
- Amino Acid Sequence, Diving, Haptoglobins metabolism, Humans, Isoelectric Point, Male, Orosomucoid chemistry, Orosomucoid metabolism, Peptides chemistry, Prealbumin chemistry, Prealbumin metabolism, Tandem Mass Spectrometry, Up-Regulation, Antioxidants metabolism, Blood Proteins metabolism, Electrophoresis, Gel, Two-Dimensional, Hypoxia, Proteome analysis
- Abstract
Saturation diving (SD) is one of the safest techniques for tolerating hyperbaric conditions for long durations. However, the changes in the human plasma protein profile that occur during SD are unknown. To identify differential protein expression during or after SD, 65 blood samples from 15 healthy Japanese men trained in SD were analyzed by two-dimensional fluorescence difference gel electrophoresis. The expression of two proteins, one 32.4 kDa with an isoelectric point (pI) of 5.8 and the other 44.8 kDa with pI 4.0, were elevated during SD to 60, 100, and 200 meters sea water (msw). The expression of these proteins returned to pre-diving level when the SD training was completed. The two proteins were identified using in-gel digestion and mass spectrometric analysis; the 32.4 kDa protein was transthyretin and the 44.8 kDa protein was alpha-1-acid glycoprotein 1. Oxidation was detected at methionine 13 of transthyretin and at methionine 129 of alpha-1-acid glycoprotein 1 by tandem mass spectrometry. Moreover, haptoglobin was up-regulated during the decompression phase of 200 msw. These plasma proteins up-regulated during SD have a common function as anti-oxidants. This suggests that by coordinating their biological effects, these proteins activate a defense mechanism to counteract the effects of hyperbaric-hyperoxic conditions during SD., Competing Interests: The authors have declared that no competing interests except for the salaries for the author [YI] who is employed by a commercial company: JEOL. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
- Published
- 2016
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25. Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.
- Author
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Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Ikebuchi Y, Ito K, Kusanagi Y, Chiba T, Tadokoro S, Takada Y, Oikawa Y, Inoue H, Suzuki K, Okada R, Nishiyama J, Domoto H, Watanabe S, Fujita M, Morimoto Y, Naito M, Nishio K, Hishida A, Wakai K, Asai Y, Niwa K, Kamakura K, Nonoyama S, Sakurai Y, Hosoya T, Kanai Y, Suzuki H, Hamajima N, and Shinomiya N
- Subjects
- ATP Binding Cassette Transporter, Subfamily G, Member 2, ATP-Binding Cassette Transporters chemistry, Amino Acid Sequence, Genotype, Humans, Japan, Molecular Sequence Data, Neoplasm Proteins chemistry, ATP-Binding Cassette Transporters genetics, Genetics, Population, Gout genetics, Mutation, Neoplasm Proteins genetics
- Abstract
Gout based on hyperuricemia is a common disease with a genetic predisposition, which causes acute arthritis. The ABCG2/BCRP gene, located in a gout-susceptibility locus on chromosome 4q, has been identified by recent genome-wide association studies of serum uric acid concentrations and gout. Urate transport assays demonstrated that ABCG2 is a high-capacity urate secretion transporter. Sequencing of the ABCG2 gene in 90 hyperuricemia patients revealed several nonfunctional ABCG2 mutations, including Q126X. Quantitative trait locus analysis of 739 individuals showed that a common dysfunctional variant of ABCG2, Q141K, increases serum uric acid. Q126X is assigned to the different disease haplotype from Q141K and increases gout risk, conferring an odds ratio of 5.97. Furthermore, 10% of gout patients (16 out of 159 cases) had genotype combinations resulting in more than 75% reduction of ABCG2 function (odds ratio, 25.8). Our findings indicate that nonfunctional variants of ABCG2 essentially block gut and renal urate excretion and cause gout.
- Published
- 2009
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26. Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia.
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Matsuo H, Chiba T, Nagamori S, Nakayama A, Domoto H, Phetdee K, Wiriyasermkul P, Kikuchi Y, Oda T, Nishiyama J, Nakamura T, Morimoto Y, Kamakura K, Sakurai Y, Nonoyama S, Kanai Y, and Shinomiya N
- Subjects
- Case-Control Studies, DNA Mutational Analysis, Exons, Heterozygote, Humans, Models, Biological, Molecular Sequence Data, Mutation, Missense, Glucose Transport Proteins, Facilitative genetics, Mutation, Uric Acid blood, Uric Acid metabolism
- Abstract
Renal hypouricemia is an inherited disorder characterized by impaired renal urate (uric acid) reabsorption and subsequent low serum urate levels, with severe complications such as exercise-induced acute renal failure and nephrolithiasis. We previously identified SLC22A12, also known as URAT1, as a causative gene of renal hypouricemia. However, hypouricemic patients without URAT1 mutations, as well as genome-wide association studies between urate and SLC2A9 (also called GLUT9), imply that GLUT9 could be another causative gene of renal hypouricemia. With a large human database, we identified two loss-of-function heterozygous mutations in GLUT9, which occur in the highly conserved "sugar transport proteins signatures 1/2." Both mutations result in loss of positive charges, one of which is reported to be an important membrane topology determinant. The oocyte expression study revealed that both GLUT9 isoforms showed high urate transport activities, whereas the mutated GLUT9 isoforms markedly reduced them. Our findings, together with previous reports on GLUT9 localization, suggest that these GLUT9 mutations cause renal hypouricemia by their decreased urate reabsorption on both sides of the renal proximal tubules. These findings also enable us to propose a physiological model of the renal urate reabsorption in which GLUT9 regulates serum urate levels in humans and can be a promising therapeutic target for gout and related cardiovascular diseases.
- Published
- 2008
- Full Text
- View/download PDF
27. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.
- Author
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Umetani M, Domoto H, Gormley AK, Yuhanna IS, Cummins CL, Javitt NB, Korach KS, Shaul PW, and Mangelsdorf DJ
- Subjects
- Animals, Aorta, Thoracic drug effects, Binding, Competitive drug effects, Cardiotonic Agents metabolism, Cell Culture Techniques, Cell Line, Cells, Cultured, Cholesterol, Dietary administration & dosage, DNA, Complementary, Dose-Response Relationship, Drug, Drug Administration Schedule, Estrogens metabolism, Female, Glutathione Transferase metabolism, Humans, Hydroxycholesterols administration & dosage, Hydroxycholesterols blood, Inhibitory Concentration 50, Injections, Subcutaneous, Kidney cytology, Kinetics, Male, Mice, Mice, Knockout, Nitric Oxide antagonists & inhibitors, Nitric Oxide Synthase Type II antagonists & inhibitors, Nitric Oxide Synthase Type III, RNA, Messenger metabolism, Receptors, Estrogen antagonists & inhibitors, Receptors, Estrogen genetics, Recombinant Fusion Proteins antagonists & inhibitors, Selective Estrogen Receptor Modulators administration & dosage, Selective Estrogen Receptor Modulators blood, Vasodilation drug effects, Cardiotonic Agents antagonists & inhibitors, Cardiotonic Agents pharmacology, Estrogens pharmacology, Hydroxycholesterols pharmacology, Selective Estrogen Receptor Modulators pharmacology
- Abstract
The cardioprotective effects of estrogen are mediated by receptors expressed in vascular cells. Here we show that 27-hydroxycholesterol (27HC), an abundant cholesterol metabolite that is elevated with hypercholesterolemia and found in atherosclerotic lesions, is a competitive antagonist of estrogen receptor action in the vasculature. 27HC inhibited both the transcription-mediated and the non-transcription-mediated estrogen-dependent production of nitric oxide by vascular cells, resulting in reduced estrogen-induced vasorelaxation of rat aorta. Furthermore, increasing 27HC levels in mice by diet-induced hypercholesterolemia, pharmacologic administration or genetic manipulation (by knocking out the gene encoding the catabolic enzyme CYP7B1) decreased estrogen-dependent expression of vascular nitric oxide synthase and repressed carotid artery reendothelialization. As well as antiestrogenic effects, there were proestrogenic actions of 27HC that were cell-type specific, indicating that 27HC functions as an endogenous selective estrogen receptor modulator (SERM). Taken together, these studies point to 27HC as a contributing factor in the loss of estrogen protection from vascular disease.
- Published
- 2007
- Full Text
- View/download PDF
28. Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma.
- Author
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Iwaya K, Oikawa K, Semba S, Tsuchiya B, Mukai Y, Otsubo T, Nagao T, Izumi M, Kuroda M, Domoto H, and Mukai K
- Subjects
- Actin-Related Protein 2 genetics, Actin-Related Protein 3 genetics, Actins physiology, Adenocarcinoma blood supply, Adenocarcinoma pathology, Colorectal Neoplasms blood supply, DNA Primers, Female, Humans, Immunohistochemistry, In Situ Hybridization, Liver Neoplasms blood supply, Liver Neoplasms pathology, Male, Neoplasm Invasiveness, Polymerase Chain Reaction, RNA, Messenger genetics, Wiskott-Aldrich Syndrome Protein Family genetics, Actin-Related Protein 2 physiology, Actin-Related Protein 3 physiology, Colorectal Neoplasms pathology, Liver Neoplasms secondary, Wiskott-Aldrich Syndrome Protein Family physiology
- Abstract
Directed movement of normal cells occurs when actin-related protein 2 and 3 complex (Arp2/3 complex) triggers the actin polymerization that forms lamellipodia immediately after binding to WAVE2. In order to determine whether the same mechanism correlates with liver metastasis from colorectal cancer, paired mirror sections of 154 cancer specimens (29 cases with liver metastasis and 125 cases without liver metastasis in which T factor, gender, primary tumor site, and age at operation were matched) were examined immunohistochemically for the localization of Arp2 and WAVE2. Expression of both Arp2 and WAVE2 was detected in the same cancer cells in 55 (35.7%) of the 154 cases, but not detected in the normal colonic epithelial cells. Univariate analysis showed that the colocalization was significantly predictive of liver metastasis (risk ratio [RR] 8.760. Likewise, histological grade (RR 2.46), lymphatic invasion (RR 9.95), and tumor budding (RR 4.00) were significant predictors. Among these, colocalization and lymphatic invasion were shown to be independent risk factors by multivariate analysis. Another 59 colorectal specimens were examined for mRNA expression of Arp2 by real time polymerase chain reaction. High mRNA levels of Arp2, that in situ hybridization revealed to be expressed by the cancer cells, were significantly associated with liver metastasis. However, its effect was absorbed by the influence of risk of the colocalization that is closely related to high expression of Arp2. These results indicate that the colocalization of Arp2 and WAVE2 is an independent risk factor for liver metastasis of colorectal carcinoma.
- Published
- 2007
- Full Text
- View/download PDF
29. A case of chronic expanding haematoma on the finger.
- Author
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Chijiwa T and Domoto H
- Subjects
- Capillaries, Chronic Disease, Endothelial Cells pathology, Fingers blood supply, Fingers surgery, Hematoma diagnostic imaging, Hematoma surgery, Humans, Immunohistochemistry methods, Male, Middle Aged, Regional Blood Flow, Ultrasonography, Fingers pathology, Hematoma pathology
- Abstract
We describe a patient with a chronic expanding haematoma developing in the right middle finger. Preoperative ultrasonography showed a cystic-like lesion upon the digital flexor tendon. Pathologic examination revealed a chronic organising haematoma surrounded by fibrous granulation tissue. Neither endothelial nor neoplastic cells were identified. We diagnosed this lesion as a chronic expanding haematoma (CEH) based upon the clinical course and pathological findings. The cause of our case was hypothesised to be repeated strain from the handle of heavy bag.
- Published
- 2006
- Full Text
- View/download PDF
30. TLS-CHOP target gene DOL54 expression in liposarcomas and malignant fibrous histiocytomas.
- Author
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Domoto H, Hosaka T, Oikawa K, Ohbayashi T, Ishida T, Izumi M, Iwaya K, Toguchida J, Kuroda M, and Mukai K
- Subjects
- Blotting, Northern, Humans, Liposarcoma, Myxoid genetics, Reverse Transcriptase Polymerase Chain Reaction, Transcription Factor CHOP, CCAAT-Enhancer-Binding Proteins biosynthesis, Gene Expression Regulation, Neoplastic, Histiocytoma, Benign Fibrous genetics, Liposarcoma genetics, Oncogene Proteins, Fusion biosynthesis, RNA-Binding Protein FUS biosynthesis
- Abstract
Downstream of the gene for the liposarcoma-associated fusion oncoprotein 54 (DOL54) is a target gene of the myxoid liposarcoma and round cell liposarcoma (M-LPS/RC-LPS) oncogene, TLS/FUS-CHOP. The DOL54 gene product is closely associated with adipogenic differentiation. DOL54 overexpression resulted in tumorigenicity when Chinese Hamster Ovary (CHO) cells were injected subcutaneously into nude mice. The biological significance of DOL54 expression for human malignant soft tissue tumors, however, has not yet been investigated. We examined TLS-CHOP and DOL54 expression in M-LPS/RC-LPS, well-differentiated liposarcoma and malignant fibrous histiocytoma (MFH), a tumor whose cellular origin has not been determined. We observed DOL54 expression in 50% of M-LPS/RC-LPS cases (in which TLS-CHOP was also expressed) and 33% of MFH cases, suggesting that a portion of MFH lesions may either derive from adipocytic precursor cells or have the potential to undergo adipogenic differentiation. In this manner, M-LPS/RC-LPS and MFH lesions may share tumorigenic characteristics, resulting from the unscheduled expression of DOL54.
- Published
- 2002
- Full Text
- View/download PDF
31. Vitamin D receptor as an intestinal bile acid sensor.
- Author
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Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, and Mangelsdorf DJ
- Subjects
- Animals, Binding, Competitive, COS Cells, Cell Line, Colonic Neoplasms prevention & control, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System genetics, Cytochrome P-450 Enzyme System metabolism, DNA-Binding Proteins metabolism, Dimerization, Gene Expression Regulation, Enzymologic, Histone Acetyltransferases, Humans, Ligands, Lithocholic Acid analogs & derivatives, Lithocholic Acid pharmacology, Male, Mice, Nuclear Receptor Coactivator 1, Oxidoreductases, N-Demethylating genetics, Oxidoreductases, N-Demethylating metabolism, Pregnane X Receptor, Promoter Regions, Genetic, Rats, Receptors, Calcitriol agonists, Receptors, Calcitriol genetics, Receptors, Cytoplasmic and Nuclear metabolism, Receptors, Steroid metabolism, Transcription Factors metabolism, Transfection, Aryl Hydrocarbon Hydroxylases, Intestine, Small metabolism, Lithocholic Acid metabolism, Receptors, Calcitriol metabolism
- Abstract
The vitamin D receptor (VDR) mediates the effects of the calcemic hormone 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3]. We show that VDR also functions as a receptor for the secondary bile acid lithocholic acid (LCA), which is hepatotoxic and a potential enteric carcinogen. VDR is an order of magnitude more sensitive to LCA and its metabolites than are other nuclear receptors. Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine. These studies offer a mechanism that may explain the proposed protective effects of vitamin D and its receptor against colon cancer.
- Published
- 2002
- Full Text
- View/download PDF
32. Invasive ductal carcinoma associated with tubular adenoma of the breast.
- Author
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Domoto H, Tsuda H, Miyakawa K, Shinoda A, and Nanasawa T
- Subjects
- Adenoma diagnostic imaging, Adenoma therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biopsy, Needle, Breast Neoplasms diagnostic imaging, Breast Neoplasms therapy, Carcinoma, Intraductal, Noninfiltrating diagnostic imaging, Carcinoma, Intraductal, Noninfiltrating therapy, Chemotherapy, Adjuvant, Cyclophosphamide administration & dosage, Female, Fluorouracil administration & dosage, Humans, Lymph Node Excision, Mammography, Mastectomy, Methotrexate administration & dosage, Middle Aged, Neoplasms, Multiple Primary diagnostic imaging, Neoplasms, Multiple Primary therapy, Radiotherapy, Treatment Outcome, Ultrasonography, Adenoma pathology, Breast Neoplasms pathology, Carcinoma, Intraductal, Noninfiltrating pathology, Neoplasms, Multiple Primary pathology
- Abstract
We report an extremely rare case of the colocalization of a tubular adenoma and an invasive ductal carcinoma occurring in a 55-year-old woman. Following radiographical evaluation, fine-needle aspiration cytology of the left breast tumor was undertaken. Because cytological examination revealed malignancy, a partial mastectomy was performed. Histologically, the tumor (measuring 1.7 x 1.3 cm) comprised two distinct parts: tubular adenoma and invasive ductal carcinoma. The invasive ductal carcinoma showed a solid pattern, high nuclear and structural atypia and frequent mitotic figures, while the tubular adenoma consisted of a proliferation of small ducts lined by single layers of epithelial and myoepithelial cells with bland nuclei and inconspicuous nucleoli. The histological boundary was clearly defined between the tubular adenoma and the invasive ductal carcinoma, and between the tubular adenoma and the surrounding breast tissue. The current case might be a collision between separate tubular adenoma and invasive ductal carcinoma, but the malignant transformation of a tubular adenoma cannot be ruled out. Both the long-term observation of this case and analysis of more cases may enable us to determine the histological characteristics and clinical significance of invasive ductal carcinoma associated with tubular adenoma.
- Published
- 2002
- Full Text
- View/download PDF
33. Decrease in platelet count during saturation diving.
- Author
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Domoto H, Nakabayashi K, Hashimoto A, Suzuki S, and Kitamura T
- Subjects
- Adult, Analysis of Variance, Cell Survival physiology, Decompression Sickness blood, Electrocardiography, Humans, Decompression Sickness diagnosis, Diving physiology, Platelet Count
- Abstract
Background: The change in platelet count (PC) occurring during saturation diving has rarely been discussed. We set out to clarify the details of this change in PC, and its relationship with: i) the storage depth and duration of the saturation dive, and ii) the presence of decompression bubbles., Methods: In a total of 42 divers, the change in PC was measured in 8 simulated saturation dives (1992-1998) using a Deep Diving Simulator with decompression procedures based on the modified DUKE-GKSS schedule. Blood samples were taken before the dive, at the bottom (twice), during decompression, on surfacing, and about 1 wk after surfacing. Decompression bubbles were examined by ultrasonic M-mode echocardiography., Results: PC (mean +/- SD x 10(4) x microl(-1)) was 23.9 +/- 4.85, 24.9 +/- 4.9, 24.2 +/- 4.8, 19.2 +/- 4.4*, 20.1 +/- 4.5*, 25.0 +/- 5.1 on the occasions listed above (*= p < 0.05 vs. pre-dive). The PC showed no correlation with either storage depth or dive duration. Decompression bubbles were detected during decompression in only 2 divers (4.8%), and the bubbles disappeared immediately after surfacing. In these 2 divers the decreases in PC values from baseline to the middle of decompression and on surfacing were 2 and 2.7 x 10(4) x microl(-1), and 3.4 and 1.7 x 10(4) x microl(-1) respectively. No diver complained of decompression sickness., Conclusion: The magnitude of the decrease in PC (< 5 x 10(4) x microl(-1)) and the time to recover to the pre-dive value (< 1 wk) suggests that changes in PC during saturation diving should not cause any clinical problems. The mechanisms underlying the decrease in PC remain unclear.
- Published
- 2001
34. Chondrosarcomatous differentiation in metastatic deposit of serous papillary cystadenocarcinoma.
- Author
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Domoto H, Mano Y, Kita T, Kikuchi Y, Sato K, Aida S, and Tamai S
- Subjects
- Cell Differentiation, Chondrosarcoma metabolism, Cystadenocarcinoma, Papillary metabolism, Diagnosis, Differential, Female, Humans, Immunohistochemistry, Keratins analysis, Lymphatic Metastasis, Middle Aged, Mucin-1 analysis, Ovarian Neoplasms metabolism, S100 Proteins analysis, Vimentin analysis, Chondrosarcoma pathology, Cystadenocarcinoma, Papillary pathology, Ovarian Neoplasms pathology
- Abstract
A rare case of serous papillary cystadenocarcinoma of the ovary showing chondrosarcomatous differentiation in a metastatic deposit late in the clinical course is reported. A 49-year-old female underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy for bilateral ovarian tumors. Histological diagnosis was serous papillary cystadenocarcinoma of both ovaries with lymph node metastasis. After six courses of chemotherapy, she was confirmed to be in complete remission following a second laparotomy. Following additional chemotherapy, a third laparotomy disclosed swollen left inguinal lymph nodes. In one of these nodes, approximately 5.0 cm in greatest diameter, the predominant histological features were: chondrosarcoma of the bone and soft tissue, with small foci of serous papillary adenocarcinoma and squamous epithelium. A histological transition between mesenchymal and epithelial areas was identified. Immunohistochemical positivity for broad-spectrum cytokeratin (AE1/AE3), vimentin, epithelial membrane antigen, and S-100 protein was observed in both chondrosarcomatous and epithelial areas. The current evidence may suggest that the chondrosarcomatous differentiation was derived from the metastatic epithelial component.
- Published
- 2000
- Full Text
- View/download PDF
35. Reduced growth hormone receptor messenger ribonucleic acid in an aged man with chronic malnutrition and growth hormone resistance.
- Author
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Shuto Y, Nakano T, Sanno N, Domoto H, Sugihara H, and Wakabayashi I
- Subjects
- Aged, Aged, 80 and over, Gene Expression, Human Growth Hormone analysis, Human Growth Hormone blood, Humans, Immunohistochemistry, Insulin-Like Growth Factor Binding Protein 3 blood, Insulin-Like Growth Factor I metabolism, Liver metabolism, Male, Pituitary Gland chemistry, Thyrotropin analysis, Drug Resistance, Human Growth Hormone pharmacology, Nutrition Disorders complications, RNA, Messenger metabolism, Receptors, Somatotropin genetics
- Abstract
A severely malnourished 87-yr-old man presented with hypoglycemia. Serum GH levels were elevated, and serum levels of insulin-like growth factor I (IGF-I), IGF-binding protein-3, and GH-binding protein were extremely reduced. The patient's GH was biologically active. Administration of GH for 4 consecutive days resulted in a slight increment in serum IGF-I levels, but no elevation of serum IGF-binding protein-3. The expression of GH receptor messenger ribonucleic acid in the liver was greatly reduced. An autopsy revealed a Rathke's cleft cyst confined to the sella turcica. Immunohistochemical studies for GH showed that there was nothing to suggest a tumor overproducing GH. In addition, TSH levels were elevated in the presence of normal thyroid hormone levels, and there was a cluster of cells showing strong immunohistochemical staining for the TSH beta-subunit in the pituitary. In this patient, the decreased expression of GH receptor messenger ribonucleic acid in the liver may have been responsible for the GH resistance, which was probably caused by malnutrition.
- Published
- 1999
- Full Text
- View/download PDF
36. Three cases of spinal decompression sickness treated by U.S. Navy Treatment Table 7.
- Author
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Ito M, Domoto H, Tadano Y, and Itoh A
- Subjects
- Adult, Decompression Sickness diagnosis, Decompression Sickness etiology, Decompression Sickness physiopathology, Humans, Hyperbaric Oxygenation adverse effects, Hyperbaric Oxygenation instrumentation, Male, Middle Aged, Respiratory Function Tests, Severity of Illness Index, Time Factors, Treatment Outcome, Decompression Sickness therapy, Diving adverse effects, Hyperbaric Oxygenation methods, Military Personnel, Naval Medicine
- Abstract
For patients of type 2 decompression sickness, recompression therapy using U.S. Navy Treatment Table 6 (TT6) and its extensions is the most common means of treatment. However, some cases are resistant to the recompression therapy, and the outcome of TT6 is not always satisfactory. Although a new table, the U.S. Navy Treatment Table 7 (TT7) was described in 1985 in the U.S. Navy Diving Manual, to date few cases who were treated using TT7 have been reported. Here, we report three cases of spinal decompression sickness who received treatment according to TT7. Two were sports scuba divers, and the other a commercial diver. TT7 was applied later than 4 d after onset in all three cases; two patients were remarkably improved during the recompression therapy, while the other improved to a certain extent after additional repetitive TT6. Mild impairment of lung function, probably due to pulmonary oxygen toxicity, was observed on lung function testing in one case. In all cases, after additional TT6 and/or rehabilitation, patients were able to return to active daily living.
- Published
- 1999
37. Nodular hidradenoma of the breast: report of two cases with literature review.
- Author
-
Domoto H, Terahata S, Sato K, and Tamai S
- Subjects
- Actins analysis, Adenoma, Sweat Gland chemistry, Adult, Biomarkers, Tumor analysis, Breast Neoplasms chemistry, Breast Neoplasms, Male chemistry, Female, Humans, Immunohistochemistry, Male, Middle Aged, Mucin-1 analysis, Sweat Gland Neoplasms chemistry, Adenoma, Sweat Gland pathology, Breast Neoplasms pathology, Breast Neoplasms, Male pathology, Sweat Gland Neoplasms pathology
- Abstract
Two cases of nodular hidradenoma of the breast with possibly different origins are reported. Case 1 is of a 58-year-old female with a breast mass in the left, outer lower-quadrant. A histogenetical origin in the skin adnexal glands was suspected due to its superficial location and immunohistochemical findings. Case 2 is of a 44-year-old male with a subareolar nodule and nipple discharge. Histological examination demonstrated that the tumor was located deep in the breast tissue, was surrounded by dilated mammary ducts and exhibited intraductal extensions, which are all features mimicking those of breast cancer. Immunohistochemical positivity against gross cystic disease fluid protein-15 was weakly identified and negativity for endoplasmic reticulum was observed. This case can be interpreted as arising in the mammary ducts. It is well known that various kinds of skin adnexal tumors arise in the breast tissue; however, nodular hidradenoma of the breast is still a rare benign neoplasm. Clinically, nodular hidradenoma of the breast tends to occur in the nipple or subareolar region of the female breast. It should be kept in mind that nodular hidradenoma may occur in mammary ducts and it should be included when differential diagnoses are made of subareolar breast tumors.
- Published
- 1998
- Full Text
- View/download PDF
38. [A case of colonic muco-submucosal elongated polyp with ischemic colitis as a first diagnostic clue].
- Author
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Domoto H, Terahata S, Sakai Y, Katoh S, Iwai A, and Itoh K
- Subjects
- Colonic Polyps pathology, Female, Humans, Intestinal Mucosa pathology, Middle Aged, Colitis, Ischemic etiology, Colonic Polyps complications, Colonic Polyps diagnosis
- Published
- 1998
39. Influence of lactation on plasma phenobarbital concentrations in rats.
- Author
-
Moriyama M, Yamashita S, Furuno K, Sato T, Domoto H, Yamatogi Y, Kawasaki H, and Gomita Y
- Subjects
- Administration, Oral, Analysis of Variance, Animals, Anticonvulsants administration & dosage, Anticonvulsants pharmacokinetics, Anticonvulsants pharmacology, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Female, Phenobarbital administration & dosage, Phenobarbital pharmacokinetics, Phenobarbital pharmacology, Pregnancy, Rats, Rats, Wistar, Anticonvulsants blood, Lactation blood, Phenobarbital blood
- Abstract
The effect of lactation on the pharmacokinetics of phenobarbital (PB) after delivery was studied in female rats. Non-pregnant animals received PB 20 mg/kg/day twice for 6-7 days before mating, during pregnancy and after delivery. Chronic PB did not significantly influence changes in the body weight of rats after delivery. On the first post-delivery day, the plasma PB concentration in the PB-treated rats was significantly higher than that in PB-treated, non-pregnant rats (non-pregnant rats); and thereafter, it gradually decreased until ablactation on the 20th day. After ablactation, plasma PB concentrations gradually returned to the level before delivery. In PB-treated rats, pharmacokinetic parameters (Cmax, AUC0-12) of PB between 0 and 12 hr after a single oral administration were significantly decreased during lactation. These results suggest that PB administered during lactation is transferred in part to offspring through maternal milk.
- Published
- 1997
- Full Text
- View/download PDF
40. Effect of pregnancy on plasma phenobarbital concentrations in rats.
- Author
-
Moriyama M, Domoto H, Yamashita S, Furuno K, Oishi R, Kawasaki H, and Gomita Y
- Subjects
- Animals, Body Weight, Female, Pregnancy, Rats, Rats, Wistar, Time Factors, Anticonvulsants pharmacokinetics, Phenobarbital pharmacokinetics, Pregnancy, Animal blood
- Abstract
We examined the pharmacokinetics of phenobarbital before and during pregnancy in rats. Animals were divided into four groups: (a) control, (b) pregnant, (c) phenobarbital-treated, and (d) phenobarbital-treated pregnant groups. The increase in body weight of nonpregnant or pregnant rats was not influenced by long-term phenobarbital treatment. Plasma phenobarbital concentrations during the period of long-term phenobarbital treatment with a fixed dosage by body weight were not significantly affected by pregnancy. Furthermore, pregnancy did not affect pharmacokinetic parameters of phenobarbital between 0.25 and 24h after administration. These results suggest that pregnancy does not influence on the pharmacokinetics of long-term phenobarbital treatment at a fixed dosage by body weight.
- Published
- 1995
- Full Text
- View/download PDF
41. Reaction of hen egg-white lysozyme with tetranitromethane: a new side reaction, oxidative bond cleavage at glycine 104, and sequential nitration of three tyrosine residues.
- Author
-
Yamada H, Yamashita T, Domoto H, and Imoto T
- Subjects
- Animals, Chickens, Egg White, Muramidase metabolism, Protein Conformation, Glycine chemistry, Muramidase chemistry, Tetranitromethane chemistry, Tyrosine chemistry
- Abstract
We found that the reaction of hen egg-white lysozyme with an equimolar amount of tetranitromethane (TNM) at pH 8.0 and room temperature yielded derivatives in which the N-C bond of Gly104 is oxidatively cleaved, and a mono-nitrotyrosine lysozyme in which Tyr23 is nitrated. This bond cleavage occurred more predominantly with a decrease in the nitration of Tyr23, when the reaction was carried out under more dilute conditions. A possible mechanism in which a phenoxyl radical of Tyr 23 (an intermediate of nitration) is involved was proposed for this oxidative bond cleavage. When lysozyme was reacted with a 10 times molar excess of TNM, in addition to a mono-nitrotyrosine lysozyme in which only Try23 is nitrated, a di-nitrotyrosine lysozyme in which Tyr20 and Tyr23 are both nitrated and a tri-nitrotyrosine lysozyme in which Tyr20, Tyr23, and Tyr53 are all nitrated were obtained. However, no other possible mono- or di-nitrotyrosine lysozymes could be isolated. Thus, it is concluded that the three tyrosine residues in lysozyme are essentially nitrated sequentially with TNM in the order of Tyr23, Tyr20, and Tyr53. Since the derivatives obtained here were all active, none of the three tyrosine residues or the residues around Gly104 are considered to be very important for the lysozyme activity.
- Published
- 1990
- Full Text
- View/download PDF
42. Dinitrophenylation as a probe for the determination of environments of amino groups in protein. Reactivities of individual amino groups in lysozyme.
- Author
-
Yamada H, Matsunaga N, Domoto H, and Imoto T
- Subjects
- Amines, Amino Acids analysis, Egg White, Peptide Fragments analysis, Protein Binding, Trypsin, Dinitrofluorobenzene, Muramidase, Nitrobenzenes, Proteins
- Abstract
Dinitrophenylation of hen egg white lysozyme with 2,4-dinitrofluorobenzene (DNFB) was carried out at pH 7-11 and room temperature in order to examine whether dinitrophenylation could be applied to determine the environments of individual amino groups in lysozyme or not. Lightly dinitrophenylated lysozyme was reduced, S-carboxymethylated and then subjected to reversed-phase high-performance liquid chromatography (RP-HPLC). All tryptic peptides, which contained dinitrophenylated amino groups (one alpha-amino group, Lys 1(alpha), and six epsilon-amino groups, Lys 1(epsilon), Lys 13, Lys 33, Lys 96, Lys 97, and Lys 116), could be separated and monitored by absorbance measurement at 360 nm on RP-HPLC. The relative reactivities of individual amino groups, determined from the relative peak areas of dinitrophenylated tryptic peptides at 360 nm, were found to be sensitive to the reaction pH and to the presence of the trimer of N-acetyl-D-glucosamine or NaCl. It was concluded that dinitrophenylation of a protein with DNFB followed by peptide analysis by RP-HPLC with detection at 360 nm is a good method for probing the environments of individual amino groups in the protein.
- Published
- 1986
- Full Text
- View/download PDF
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