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16 results on '"Domnich, Maksim"'

1. Nonfunctional TGF-β/ALK1/ENG signaling pathway supports neutrophil proangiogenic activity in hereditary hemorrhagic telangiectasia

Author

Duerig, Inga, primary, Pylaeva, Ekaterina, additional, Ozel, Irem, additional, Wainwright, Sami, additional, Thiel, Ilona, additional, Bordbari, Sharareh, additional, Domnich, Maksim, additional, Siakaeva, Elena, additional, Lakomek, Antonia, additional, Toppe, Felicia, additional, Schleupner, Carolin, additional, Geisthoff, Urban, additional, Lang, Stephan, additional, Droege, Freya, additional, and Jablonska, Jadwiga, additional

Published
2023
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2. During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes

Author

Pylaeva, Ekaterina, primary, Korschunow, Georg, additional, Spyra, Ilona, additional, Bordbari, Sharareh, additional, Siakaeva, Elena, additional, Ozel, Irem, additional, Domnich, Maksim, additional, Squire, Anthony, additional, Hasenberg, Anja, additional, Thangavelu, Kruthika, additional, Hussain, Timon, additional, Goetz, Moritz, additional, Lang, Karl S., additional, Gunzer, Matthias, additional, Hansen, Wiebke, additional, Buer, Jan, additional, Bankfalvi, Agnes, additional, Lang, Stephan, additional, and Jablonska, Jadwiga, additional

Published
2022
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3. IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes

Author

Hussain, Timon, primary, Domnich, Maksim, additional, Bordbari, Sharareh, additional, Pylaeva, Ekaterina, additional, Siakaeva, Elena, additional, Spyra, Ilona, additional, Ozel, Irem, additional, Droege, Freya, additional, Squire, Anthony, additional, Lienenklaus, Stefan, additional, Sutter, Kathrin, additional, Hasenberg, Anja, additional, Gunzer, Matthias, additional, Lang, Stephan, additional, and Jablonska, Jadwiga, additional

Published
2022
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4. Evaluation of Immunoregulatory Biomarkers on Plasma Small Extracellular Vesicles for Disease Progression and Early Therapeutic Response in Head and Neck Cancer

Author

Jablonska, Jadwiga, primary, Rist, Malwina, additional, Spyra, Ilona, additional, Tengler, Luisa, additional, Domnich, Maksim, additional, Kansy, Benjamin, additional, Giebel, Bernd, additional, Thakur, Basant Kumar, additional, Rotter, Nicole, additional, Lang, Stephan, additional, and Ludwig, Sonja, additional

Published
2022
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6. SIRT1 ‐mediated deacetylation of FOXO3a transcription factor supports pro‐angiogenic activity of interferon‐deficient tumor‐associated neutrophils

Author

Bordbari, Sharareh, primary, Mörchen, Britta, additional, Pylaeva, Ekaterina, additional, Siakaeva, Elena, additional, Spyra, Ilona, additional, Domnich, Maksim, additional, Droege, Freya, additional, Kanaan, Oliver, additional, Lang, Karl Sebastian, additional, Schadendorf, Dirk, additional, Lang, Stephan, additional, Helfrich, Iris, additional, and Jablonska, Jadwiga, additional

Published
2021
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7. B-Helper Neutrophils in Regional Lymph Nodes Correlate with Improved Prognosis in Patients with Head and Neck Cancer

Author

Pylaeva, Ekaterina, primary, Ozel, Irem, additional, Squire, Anthony, additional, Spyra, Ilona, additional, Wallner, Charlotte, additional, Korek, Magdalena, additional, Korschunow, Georg, additional, Domnich, Maksim, additional, Siakaeva, Elena, additional, Goetz, Moritz, additional, Bankfalvi, Agnes, additional, Lang, Stephan, additional, Kansy, Benjamin, additional, and Jablonska, Jadwiga, additional

Published
2021
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8. SIRT1‐mediated deacetylation of FOXO3a transcription factor supports pro‐angiogenic activity of interferon‐deficient tumor‐associated neutrophils.

Author

Bordbari, Sharareh, Mörchen, Britta, Pylaeva, Ekaterina, Siakaeva, Elena, Spyra, Ilona, Domnich, Maksim, Droege, Freya, Kanaan, Oliver, Lang, Karl Sebastian, Schadendorf, Dirk, Lang, Stephan, Helfrich, Iris, and Jablonska, Jadwiga

Subjects
FORKHEAD transcription factors, TRANSCRIPTION factors, NEUTROPHILS, TYPE I interferons, DEACETYLATION, POST-translational modification
Abstract

Angiogenesis plays an important role during tumor growth and metastasis. We could previously show that Type I interferon (IFN)‐deficient tumor‐associated neutrophils (TANs) show strong pro‐angiogenic activity, and stimulate tumor angiogenesis and growth. However, the exact mechanism responsible for their pro‐angiogenic shift is not clear. Here, we set out to delineate the molecular mechanism and factors regulating pro‐angiogenic properties of neutrophils in the context of Type I IFN availability. We demonstrate that neutrophils from IFN‐deficient (Ifnar1−/−) mice efficiently release pro‐angiogenic factors, such as VEGF, MMP9 or BV8, and thus significantly support the vascular normalization of tumors by increasing the maturation of perivascular cells. Mechanistically, we could show here that the expression of pro‐angiogenic factors in neutrophils is controlled by the transcription factor forkhead box protein O3a (FOXO3a), which activity depends on its post‐translational modifications, such as deacetylation or phosphorylation. In TANs isolated from Ifnar1−/− mice, we observe significantly elevated SIRT1, resulting in SIRT1‐mediated deacetylation of FOXO3a, its nuclear retention and activation. Activated FOXO3a supports in turn the transcription of pro‐angiogenic genes in TANs. In the absence of SIRT1, or after its inhibition in neutrophils, elevated kinase MEK/ERK and PI3K/AKT activity is observed, leading to FOXO3a phosphorylation, cytoplasmic transfer and inactivation. In summary, we have found that FOXO3a is a key transcription factor controlling the angiogenic switch of neutrophils. Post‐translational FOXO3a modifications regulate its transcriptional activity and, as a result, the expression of pro‐angiogenic factors supporting development of vascular network in growing tumors. Therefore, targeting FOXO3a activity could provide a novel strategy of antiangiogenic targeted therapy for cancer. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Impaired Release of Neutrophil Extracellular Traps and Anemia-Associated T Cell Deficiency in Hereditary Hemorrhagic Telangiectasia

Author

Droege, Freya, primary, Pylaeva, Ekaterina, additional, Siakaeva, Elena, additional, Bordbari, Sharareh, additional, Spyra, Ilona, additional, Thangavelu, Kruthika, additional, Lueb, Carolin, additional, Domnich, Maksim, additional, Lang, Stephan, additional, Geisthoff, Urban, additional, and Jablonska, Jadwiga, additional

Published
2020
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