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7. The influence of tumor- and treatment-related factors on the development of local recurrence in osteosarcoma after adequate surgery. An analysis of 1355 patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols

Author

Andreou, D., Bielack, S.S., Carrle, D., Kevric, M., Kotz, R., Winkelmann, W., Jundt, G., Werner, M., Fehlberg, S., Kager, L., Kühne, T., Lang, S., Dominkus, M., Exner, G.U., Hardes, J., Hillmann, A., Ewerbeck, V., Heise, U., Reichardt, P., and Tunn, P. -U.

Published
2011
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8. Das Klarzellsarkom der Sehnen, Aponeurosen und Fascien – Eine internationale Multicenterstudie der European Musculo-skeletal Oncology Society (EMSOS) und der Sektion 13 Muskuloskelettale Tumoren der DGOOC

Author

Bruns, J, Hillmann, M, Frenos, F, Dominkus, M, Kluba, T, Südkamp, NP, Panzica, M, Tunn, PU, Alpan, B, Hardes, J, Bakhshai, Y, Goldenitsch, E, Leithner, A, Lenze, U, San-Julian Aranguren, M, Rudert, M, and Gebert, C

Subjects
Fascien, ddc: 610, Sehnen, Überleben, Medicine and health, Aponeurose, Weichteiltumor, Klarzellsarkom, Therapie
Abstract

Fragestellung: Das Klarzellsarkom der Sehnen, Aponeurosen und Fascien (CCSA) ist ein seltenes Weichteilsarkom, über das es kaum größere Erfahrungen gibt. Deshalb wurde von der EMSOS in Kooperation mit der Sektion Tumoren der DGOOC eine retrospektive, internationale Multicenter-Studie [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2021
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35. Osteosarcoma over the age of forty

Author

Grimer, R.J, Cannon, S.R, Taminiau, A.M, Bielack, S, Kempf-Bielack, B, Windhager, R, Dominkus, M, Saeter, G, Bauer, H, Meller, I, Szendroi, M, Folleras, G, San-Julian, M, and van der Eijken, J

Published
2003
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39. The influence of tumor- and treatment-related factors on the development of local recurrence in osteosarcoma after adequate surgery. An analysis of 1355 patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols

Author

Andreou, D., Bielack, S. S., Carrle, D., Kevric, M., Kotz, R., Winkelmann, W., Jundt, G., Werner, M., Fehlberg, S., Kager, L., Kühne, T., Lang, S., Dominkus, M., Exner, G. U., Hardes, J., Hillmann, A., Ewerbeck, V., Heise, U., Reichardt, P., Tunn, P. -U, Andreou, D., Bielack, S. S., Carrle, D., Kevric, M., Kotz, R., Winkelmann, W., Jundt, G., Werner, M., Fehlberg, S., Kager, L., Kühne, T., Lang, S., Dominkus, M., Exner, G. U., Hardes, J., Hillmann, A., Ewerbeck, V., Heise, U., Reichardt, P., and Tunn, P. -U

Abstract

Background: Local recurrence (LR) in osteosarcoma is associated with very poor prognosis. We sought to evaluate which factors correlate with LR in patients who achieved complete surgical remission with adequate margins. Patients and methods: We analyzed 1355 patients with previously untreated high-grade central osteosarcoma of the extremities, the shoulder and the pelvis registered in neoadjuvant Cooperative Osteosarcoma Study Group trials between 1986 and 2005. Seventy-six patients developed LR. Results: Median follow-up was 5.56 years. No participation in a study, pelvic tumor site, limb-sparing surgery, soft tissue infiltration beyond the periosteum, poor response to neoadjuvant chemotherapy, failure to complete the planned chemotherapy protocol and biopsy at a center other than the one performing the tumor resection were significantly associated with a higher LR rate. No differences were found for varying surgical margin widths. Surgical treatment at centers with small patient volume and additional surgery in the primary tumor area, other than biopsy and tumor resection, were significantly associated with a higher rate of ablative surgery. Conclusions: Patient enrollment in clinical trials and performing the biopsy at experienced institutions capable of undertaking the tumor resection without compromising the oncological and functional outcome should be pursued in the future

Published
2017

50. The influence of tumor- and treatment-related factors on the development of local recurrence in osteosarcoma after adequate surgery. An analysis of 1355 patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols

Author

Andreou, D, Bielack, S S, Carrle, D, Kevric, M, Kotz, R, Winkelmann, W, Jundt, G, Werner, M, Fehlberg, S, Kager, L, Kühne, T, Lang, S, Dominkus, M, Exner, G U, Hardes, J, Hillmann, A, Ewerbeck, V, Heise, U, Reichardt, P, Tunn, P-U, Andreou, D, Bielack, S S, Carrle, D, Kevric, M, Kotz, R, Winkelmann, W, Jundt, G, Werner, M, Fehlberg, S, Kager, L, Kühne, T, Lang, S, Dominkus, M, Exner, G U, Hardes, J, Hillmann, A, Ewerbeck, V, Heise, U, Reichardt, P, and Tunn, P-U

Abstract

Patient enrollment in clinical trials and performing the biopsy at experienced institutions capable of undertaking the tumor resection without compromising the oncological and functional outcome should be pursued in the future.

Published
2011

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