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3 results on '"Dominique Lespinasse"'

1. People Living With HIV Have More Intact HIV DNA in Circulating CD4+ T Cells if They Have History of Pulmonary Tuberculosis

Author

Marc Antoine Jean Juste, Yvetot Joseph, Dominique Lespinasse, Alexandra Apollon, Parmida Jamshidi, Myung Hee Lee, Maureen Ward, Esther Brill, Yanique Duffus, Uche Chukwukere, Ali Danesh, Winiffer Alberto, Daniel Fitzgerald, Jean Pape, R Jones, and Kathryn Dupnik

Subjects
HIV, tuberculosis, virus latency, proviruses, Haiti, interleukin-1, Pathology, RB1-214, Immunologic diseases. Allergy, RC581-607
Abstract

Background: A primary barrier to curing HIV is the HIV reservoir. The leading infectious cause of death worldwide for people living with HIV is tuberculosis (TB), but we do not know how TB impacts the HIV reservoir. Methods: Participants in identification and validation cohorts were selected from previously enrolled studies at Groupe Haïtien d’Étude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO) in Port au Prince, Haiti. Intact and non-intact proviral DNA were quantified using droplet digital PCR of peripheral blood mononuclear cell (PBMC)-derived CD4+ T cells. Kruskal-Wallis tests were used to compare medians with tobit regression for censoring. Results: In the identification cohort, we found that people living with HIV with a history of active pulmonary TB (n=19) had higher levels of intact provirus than people living with HIV without a history of active TB (n=47) (median 762; IQR, 183-1173 vs 117; IQR, 24-279 intact provirus per million CD4, respectively; P=0.0001). This difference also was seen in the validation cohort (n=31), (median 102; IQR, 0-737 vs 0; IQR, 0-24.5 intact provirus per million CD4, P=0.03) for TB vs no-TB history groups, respectively. The frequencies of CD4+ T cells with any detectable proviral fragment was directly proportional to the levels of interleukin-1 beta (r=0.524, P= 0.0025) and interleukin-2 (r=0.622, P=0.0002). Conclusions: People living with HIV with a history of active pulmonary TB have more HIV provirus in their circulating CD4+ T cells, even years after TB cure. We need to characterize which CD4+ T cells are harboring intact provirus to consider the impact of T cell-targeting HIV cure interventions for people living in TB-endemic areas.

Published
2024
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2. Individual and Composite Adverse Pregnancy Outcomes in a Randomized Trial on Isoniazid Preventative Therapy Among Women Living With Human Immunodeficiency Virus

Author

Nahida Chakhtoura, Fuanglada Tongprasert, Mandisa Nyati, Grace Montepiedra, Amy James Loftis, Gaerolwe Masheto, Patrick Jean-Philippe, Tsungai Chipato, Sandesh Patil, Carolyne Onyango-Makumbi, James S. Ngocho, Teacler Nematadzira, Dominique Lespinasse, Bonnie Zimmer, Amita Gupta, Gerhard Theron, Adriana Weinberg, Katie McCarthy, and Lisa Aaron

Subjects
IPT, Microbiology (medical), medicine.medical_specialty, adverse pregnancy outcomes, Adolescent, medicine.medical_treatment, HIV Infections, 030204 cardiovascular system & hematology, Logistic regression, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Acquired immunodeficiency syndrome (AIDS), Pregnancy, law, parasitic diseases, Isoniazid, Humans, Tuberculosis, Medicine, 030212 general & internal medicine, Child, Online Only Articles, business.industry, Obstetrics, Infant, Newborn, Pregnancy Outcome, HIV, medicine.disease, Confidence interval, Clinical trial, Major Articles and Commentaries, Low birth weight, AcademicSubjects/MED00290, Infectious Diseases, Interpersonal psychotherapy, Female, medicine.symptom, business
Abstract

Background International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1078, a randomized noninferiority study designed to compare the safety of starting isoniazid preventive therapy (IPT) in women living with human immunodeficiency virus (HIV) either during pregnancy or after delivery, showed that IPT during pregnancy increased the risk of composite adverse pregnancy outcomes, but not individual outcomes. Many known factors are associated with adverse pregnancy outcomes: these factors’ associations and effect modifications with IPT and pregnancy outcomes were examined. Methods Pregnant women living with HIV from 8 countries with tuberculosis incidences >60/100 000 were randomly assigned to initiate 28 weeks of IPT either during pregnancy or at 12 weeks after delivery. Using univariable and multivariable logistic regression and adjusting for factors associated with pregnancy outcomes, composite and individual adverse pregnancy outcome measures were analyzed. Results This secondary analysis included 925 mother-infant pairs. All mothers were receiving antiretrovirals. The adjusted odds of fetal demise, preterm delivery (PTD), low birth weight (LBW), or a congenital anomaly (composite outcome 1) were 1.63 times higher among women on immediate compared to deferred IPT (95% confidence interval [CI], 1.15–2.31). The odds of fetal demise, PTD, LBW, or neonatal death within 28 days (composite outcome 2) were 1.62 times higher among women on immediate IPT (95% CI, 1.14–2.30). The odds of early neonatal death within 7 days, fetal demise, PTD, or LBW (composite outcome 3) were 1.74 times higher among women on immediate IPT (95% CI, 1.22–2.49). Conclusions We confirmed higher risks of adverse pregnancy outcomes associated with the initiation of IPT during pregnancy, after adjusting for known risk factors for adverse pregnancy outcomes., After adjusting for known risk factors, we compared composite and individual adverse pregnancy outcomes in women with human immunodeficiency virus initiating isoniazid preventive therapy during or after pregnancy, and found higher risks of adverse pregnancy outcomes with initiation during pregnancy.

Published
2020

3. Synthetic Approach to D-Psicofuranosyl Nucleosides and Their 1-Deoxy Analogues

Author

Annie Brouiller, Jean-Marc Ricca, and Anne-Dominique Lespinasse

Subjects
chemistry.chemical_classification, Nucleophilic addition, Chemistry, Stereochemistry, Reagent, Genetics, Organic chemistry, Sugar moiety, Biochemistry, Lactone
Abstract

The sugar moiety of ketofuranosyl nucleosides derived from D-psicofuranose and 1-deoxy-D-psicofuranose are readily available through nucleophilic addition of D-ribono-1,4 -lactone with lithiated reagents.

Published
1988

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