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165 results on '"Dominique, Stéphane"'

1. CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma

Author

Mal, Hervé, Le Guen, Pierre, Dupin, Clairelyne, Meurice, Jean Claude, Verdaguer, Marion, de Keizer, Joe, Delétage-Métreau, Céline, Le Mao, Raphael, Tromer, Cécile, Fajole, Gaëlle, Rayez, Mélanie, Raymond, Christel Saint, Gheerbrant, Hubert, Badatcheff, Anne, Person, Christine, Macey, Julie, Dermant, Xavier, Boitiaux, Jean-François, Gosset-Woimant, Marine, Metz-Favre, Carine, Degot, Tristan, Poulet, Claire, Popin, Elisabeth, Gamez, Anne Sophie, Boissin, Clément, Prevotat, Anne, Mangiapan, Gilles, Brouquières, Danielle, Le Floch, Hervé, Morisse-Pradier, Hélène, Sattler, Caroline, Muti, Daniela, Germaud, Patrick, Dirou, Stéphanie, Paris, Audrey, Melloni, Boris, Ballouhey, Julia, Bondeelle, Louise, Laurent, Lucie, Belleguic, Chantal, Kerjouan, Mallorie, Deslée, Gaëtan, Dury, Sandra, Bergot, Emmanuel, Magnier, Romain, Morel, Hugues, Lemaire, Bertrand, Tumino, Cécile, Sénéchal, Agathe, Choinier, Pascaline, Parrot, Antoine, Godet, Cendrine, Brun, Anne-Laure, Couturaud, Francis, Laurent, François, Frat, Jean-Pierre, Marchand-Adam, Sylvain, Gagnadoux, Frédéric, Blanchard, Elodie, Taillé, Camille, Philippe, Bruno, Hirschi, Sandrine, Andréjak, Claire, Bourdin, Arnaud, Chenivesse, Cécile, Dominique, Stéphane, Murris-Espin, Marlène, Rivière, Frédéric, Garcia, Gilles, Blanc, François-Xavier, Goupil, François, Bergeron, Anne, Flament, Thomas, Priou, Pascaline, Ragot, Stéphanie, and Cadranel, Jacques

Published
2024
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2. Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Naccache, Jean-Marc, Jouneau, Stéphane, Didier, Morgane, Borie, Raphaël, Cachanado, Marine, Bourdin, Arnaud, Reynaud-Gaubert, Martine, Bonniaud, Philippe, Israël-Biet, Dominique, Prévot, Grégoire, Hirschi, Sandrine, Lebargy, François, Marchand-Adam, Sylvain, Bautin, Nathalie, Traclet, Julie, Gomez, Emmanuel, Leroy, Sylvie, Gagnadoux, Frédéric, Rivière, Frédéric, Bergot, Emmanuel, Gondouin, Anne, Blanchard, Elodie, Parrot, Antoine, Blanc, François-Xavier, Chabrol, Alexandre, Dominique, Stéphane, Gibelin, Aude, Tazi, Abdellatif, Berard, Laurence, Brillet, Pierre Yves, Debray, Marie-Pierre, Rousseau, Alexandra, Kerjouan, Mallorie, Freynet, Olivia, Dombret, Marie-Christine, Gamez, Anne-Sophie, Nieves, Ana, Beltramo, Guillaume, Pastré, Jean, Le Borgne-Krams, Aurélie, Dégot, Tristan, Launois, Claire, Plantier, Laurent, Wémeau-Stervinou, Lidwine, Cadranel, Jacques, Chenivesse, Cécile, Valeyre, Dominique, Crestani, Bruno, Cottin, Vincent, Simon, Tabassome, and Nunes, Hilario

Published
2022
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3. Clinical phenotype of adult-onset systemic histiocytosis harboring BRAF in-frame deletions

Author

Papo, Matthias, primary, Razanamahéry, Jérôme, additional, Da Silva, Malik, additional, Hélias-Rodzewicz, Zofia, additional, Potapenko, Vsevolod, additional, Bota, Suzanna, additional, Leguy-Seguin, Vanessa, additional, Dominique, Stéphane, additional, Lhote, Raphaël, additional, Moyon, Quentin, additional, Taïeb, Dov, additional, Abrassart, Tom, additional, Campana, Marion, additional, Keo, Visal, additional, Rivière, Etienne, additional, Lucidarme, Olivier, additional, Cohen-Aubart, Fleur, additional, Amoura, Zahir, additional, Haroche, Julien, additional, and Emile, Jean-François, additional

Published
2024
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4. CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma.

Author

Godet, Cendrine, Brun, Anne-Laure, Couturaud, Francis, Laurent, François, Frat, Jean-Pierre, Marchand-Adam, Sylvain, Gagnadoux, Frédéric, Blanchard, Elodie, Taillé, Camille, Philippe, Bruno, Hirschi, Sandrine, Andréjak, Claire, Bourdin, Arnaud, Chenivesse, Cécile, Dominique, Stéphane, Mangiapan, Gilles, Murris-Espin, Marlène, Rivière, Frédéric, Garcia, Gilles, and Blanc, François-Xavier

Subjects
PULMONARY aspergillosis, ASTHMA, COMPUTED tomography, END of treatment, ADULTS
Abstract

One of the major challenges in managing allergic bronchopulmonary aspergillosis remains consistent and reproducible assessment of response to treatment. What are the most relevant changes in CT scan parameters over time for assessing response to treatment? In this ancillary study of a randomized clinical trial (NebuLamB), patients with asthma with available CT scan and without exacerbation during a 4-month allergic bronchopulmonary aspergillosis exacerbation treatment period (corticosteroids and itraconazole) were included. Changed CT scan parameters were assessed by systematic analyses of CT scan findings at initiation and end of treatment. CT scans were assessed by two radiologists anonymized to the clinical data. Radiologic parameters were determined by selecting those showing significant changes over time. Improvement of at least one, without worsening of the others, defined the radiologic response. Agreement between radiologic changes and clinical and immunologic responses was likewise investigated. Among the 139 originally randomized patients, 132 were included. We identified five CT scan parameters showing significant changes at end of treatment: mucoid impaction extent, mucoid impaction density, centrilobular micronodules, consolidation/ground-glass opacities, and bronchial wall thickening (P <.05). These changes were only weakly associated with one another, except for mucoid impaction extent and density. No agreement was observed between clinical, immunologic, and radiologic responses, assessed as an overall response, or considering each of the parameters (Cohen κ, −0.01 to 0.24). Changes in extent and density of mucoid impaction, centrilobular micronodules, consolidation/ground-glass opacities, and thickening of the bronchial walls were found to be the most relevant CT scan parameters to assess radiologic response to treatment. A clinical, immunologic, and radiologic multidimensional approach should be adopted to assess outcomes, probably with a composite definition of response to treatment. ClinicalTrials.gov; No.: NCT02273661; URL: www.clinicaltrials.gov) [ABSTRACT FROM AUTHOR]

Published
2024
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7. Similarities and differences of interstitial lung disease associated with pathogenic variants in SFTPC and ABCA3 in adults.

Author

Diesler, Rémi, Legendre, Marie, Si‐Mohamed, Salim, Brillet, Pierre‐Yves, Wemeau, Lidwine, Manali, Effrosyni D., Gagnadoux, Frédéric, Hirschi, Sandrine, Lorillon, Gwenaël, Reynaud‐Gaubert, Martine, Bironneau, Vanessa, Blanchard, Elodie, Bourdin, Arnaud, Dominique, Stéphane, Justet, Aurélien, Macey, Julie, Marchand‐Adam, Sylvain, Morisse‐Pradier, Hélène, Nunes, Hilario, and Papiris, Spyros A.

Subjects
INTERSTITIAL lung diseases, IDIOPATHIC pulmonary fibrosis, PULMONARY fibrosis, ADULTS, COMPUTED tomography, LUNG transplantation
Abstract

Background and Objective: Variants in surfactant genes SFTPC or ABCA3 are responsible for interstitial lung disease (ILD) in children and adults, with few studies in adults. Methods: We conducted a multicentre retrospective study of all consecutive adult patients diagnosed with ILD associated with variants in SFTPC or ABCA3 in the French rare pulmonary diseases network, OrphaLung. Variants and chest computed tomography (CT) features were centrally reviewed. Results: We included 36 patients (median age: 34 years, 20 males), 22 in the SFTPC group and 14 in the ABCA3 group. Clinical characteristics were similar between groups. Baseline median FVC was 59% ([52–72]) and DLco was 44% ([35–50]). An unclassifiable pattern of fibrosing ILD was the most frequent on chest CT, found in 85% of patients, however with a distinct phenotype with ground‐glass opacities and/or cysts. Nonspecific interstitial pneumonia and usual interstitial pneumonia were the most common histological patterns in the ABCA3 group and in the SFTPC group, respectively. Annually, FVC and DLCO declined by 1.87% and 2.43% in the SFTPC group, respectively, and by 0.72% and 0.95% in the ABCA3 group, respectively (FVC, p = 0.014 and DLCO, p = 0.004 for comparison between groups). Median time to death or lung transplantation was 10 years in the SFTPC group and was not reached at the end of follow‐up in the ABCA3 group. Conclusion: SFTPC and ABCA3‐associated ILD present with a distinct phenotype and prognosis. A radiologic pattern of fibrosing ILD with ground‐glass opacities and/or cysts is frequently found in these rare conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Phenotypic characterization of interstitial lung disease associated with mutations in SFTPC and ABCA3 in adults

Author

Diesler, Rémi, primary, Legendre, Marie, additional, Si-Mohamed, Salim, additional, Brillet, Pierre-Yves, additional, Wemeau, Lidwine, additional, Manali, Effrosyni D, additional, Gagnadoux, Frédéric, additional, Gondouin, Anne, additional, Hirschi, Sandrine, additional, Lorillon, Gwenael, additional, Reynaud-Gaubert, Martine, additional, Bironneau, Vanessa, additional, Blanchard, Elodie, additional, Bourdin, Arnaud, additional, Dominique, Stéphane, additional, Justet, Aurélien, additional, Macey, Julie, additional, Marchand-Adam, Sylvain, additional, Morisse-Pradier, Hélène, additional, Nunes, Hilario, additional, Papiris, Spyros, additional, Traclet, Julie, additional, Crestani, Bruno, additional, Amsellem, Serge, additional, Nathan, Nadia, additional, Borie, Raphaël, additional, and Cottin, Vincent, additional

Published
2023
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11. Central venous thrombosis and thrombophilia in cystic fibrosis: A prospective study

Author

Munck, Anne, Kheniche, Ahmed, Alberti, Corinne, Hubert, Dominique, Martine, Reynaud-Gaubert, Nove-Josserand, Raphaele, Pin, Isabelle, Bremont, Francois, Chiron, Raphael, Couderc, Laure, Dalphin, Marie Laure, Darviot, Estelle, Delaisi, Bertrand, Dominique, Stéphane, Durieu, Isabelle, Fanton, Annelyse, Fayon, Michael, Gérardin, Michèle, Giniès, Jean-Louis, Giraut, Charlotte, Grenet, Dominique, Guillot, Marcel, Huet, Frédéric, Le bourgeois, Muriel, Murris-Epin, Marlène, Ramel, Sophie, Sardet, Anne, Sermet-Gaudelus, Isabelle, Varaigne, Françoise, Wanin, Stéphanie, Weiss, Laurence, and Hurtaud, Marie-Francoise

Published
2015
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12. Interest of TAPSE/sPAP ratio for noninvasive pulmonary arterial hypertension risk assessment

Author

Fauvel, Charles, primary, Raitiere, Olivier, additional, Boucly, Athénaïs, additional, De Groote, Pascal, additional, Renard, Sébastien, additional, Bertona, Jeanne, additional, Lamblin, Nicolas, additional, Artaud-Macari, Elise, additional, Viacroze, Catherine, additional, Schleifer, Dominique, additional, Dominique, Stéphane, additional, Pichon, Jérémie, additional, Jais, Xavier, additional, Montani, David, additional, Sitbon, Olivier, additional, Savale, Laurent, additional, Humbert, Marc, additional, and Bauer, Fabrice, additional

Published
2022
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17. Rapid Improvement after Starting Elexacaftor–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and Advanced Pulmonary Disease

Author

Burgel, Pierre-Régis, primary, Durieu, Isabelle, additional, Chiron, Raphaël, additional, Ramel, Sophie, additional, Danner-Boucher, Isabelle, additional, Prevotat, Anne, additional, Grenet, Dominique, additional, Marguet, Christophe, additional, Reynaud-Gaubert, Martine, additional, Macey, Julie, additional, Mely, Laurent, additional, Fanton, Annlyse, additional, Quetant, Sébastien, additional, Lemonnier, Lydie, additional, Paillasseur, Jean-Louis, additional, Da Silva, Jennifer, additional, Martin, Clémence, additional, Andrejak, Claire, additional, Becourt, Arnaud, additional, Mounard, Julie, additional, Poulet, Claire, additional, Rames, Cinthia, additional, Talleux, Marie, additional, Chevalier, Marie-Chantal, additional, Darviot, Estelle, additional, Jouvenot, Marie, additional, Marien, Caroline, additional, Paris, Audrey, additional, Pelatan, Cécile, additional, Person, Christine, additional, Priou, Pascaline, additional, Troussier, Françoise, additional, Urban, Thierry, additional, Dalphin, Marie-Laure, additional, Dalphin, Jean-Charles, additional, Ladaurade, Alice, additional, Pernet, Didier, additional, Richaud-Thiriez, Bénédicte, additional, Roux-Claude, Pauline, additional, Blanc, Nathalia, additional, Boisserie-Lacroix, Vincent, additional, Bui, Stephanie, additional, Collet, Cyrielle, additional, Debelleix, Stéphane, additional, Bergot, Emmanuel, additional, Brouard, Jacques, additional, Campbell, Karine, additional, Laurans, Muriel, additional, Ribault, Virginie, additional, Borderon, Corinne, additional, Heraud, Marie-Christine, additional, Labbe, Guillaume, additional, Montcouquiol, Sylvie, additional, Petit, Isabelle, additional, Ruivard, Marc, additional, Delestrain, Céline, additional, Douvry, Benoit, additional, Epaud, Ralph, additional, Maitre, Bernard, additional, Remus, Natascha, additional, Beltramo, Guillaume, additional, Houzel, Anne, additional, Huet, Frédéric, additional, Perez, Stéphanie, additional, Boldron-Ghaddar, Amale, additional, Scalbert, Manuela, additional, Bouzioukh, Rabah, additional, Simon, Charles, additional, Camara, Boubou, additional, Hamidfar, Rébecca, additional, Llerena, Catherine, additional, Pin, Isabelle, additional, Deschildre, Antoine, additional, Gicquello, Alice, additional, Le Rouzic, Olivier, additional, Leroy, Clara, additional, Paris, Nicolas, additional, Perez, Thierry, additional, Thumerelle, Caroline, additional, Turck, Dominique, additional, Wizla, Nathalie, additional, Dupuy-Grasset, Magali, additional, Languepin, Jane, additional, Masson-Rouchaud, Alexandra, additional, Menetrey, Céline, additional, Durupt, Stéphane, additional, L’Excellent, Sophie, additional, Nove-Josserand, Raphaele, additional, Ohlmann, Camille, additional, Reix, Phillipe, additional, Reynaud, Quitterie, additional, Werck-Gallois, Marie-Christine, additional, Baravalle, Mélissandre, additional, Coltey, Bérangère, additional, Desmazes-Dufeu, Nadine, additional, Dubus, Jean-Christophe, additional, Gautier, Clarisse, additional, Rey, Jean-Baptiste, additional, Stremler, Nathalie, additional, Caimmi, Davide, additional, Devrait, Margot, additional, Moreau, Johan, additional, Billon, Yves, additional, Blondé, Aurore, additional, Guillaumot, Anne, additional, Kiefer, Sébastien, additional, Peretti, Laura, additional, Tatopoulos, Aurélie, additional, Tiotiu, Angélica, additional, Benhamida, Myriam, additional, Bihouee, Tiphaine, additional, Eschapasse, Emmanuel, additional, Tissot, Adrien, additional, Giannantonio, Marie, additional, Leroy, Sylvie, additional, Piccini-Bailly, Carole, additional, Pradelli, Johana, additional, Messika, Jonathan, additional, Boussaud, Véronique, additional, Burgel, Pierre-Régis, additional, Carlier, Nicolas, additional, Honoré, Isabelle, additional, Hubert, Dominique, additional, Kanaan, Reem, additional, Bailly-Botuha, Céline, additional, Chedevergne, Frédérique, additional, De Blic, Jacques, additional, Delacourt, Christophe, additional, Drummond, David, additional, Fauroux, Brigitte, additional, Karila, Chantal, additional, Le Bourgeois, Muriel, additional, Sermet, Isabelle, additional, Delaisi, Bertrand, additional, Gerardin, Michèle, additional, Houdouin, Veronique, additional, Leclainche, Laurence, additional, Aubertin, Guillaume, additional, Berdah, Laura, additional, Clement, Annick, additional, Corvol, Harriet, additional, Nathan, Nadia, additional, Prevost, Blandine, additional, Richard, Nicolas, additional, Tamalet, Aline, additional, Taytard, Jessica, additional, Thouvenin, Guillaume, additional, Tourniaire, Barbara, additional, Abely, Michel, additional, Bessaci-Kabouya, Katia, additional, Dury, Sandra, additional, Ravoninjatovo, Bruno, additional, Dabadie, Alain, additional, Dagorne, Michel, additional, Deneuville, Eric, additional, Jamin, Marie, additional, Ribault, Mélanie, additional, Vigier, Clémentine, additional, Belleguic, Chantal, additional, Brinchault, Graziella, additional, Desrues, Benoit, additional, Barzic, Audrey, additional, Dirou-Prigent, Anne, additional, Le Bihan, Jean, additional, Revert, Krista, additional, Ropars, Thomas, additional, Couderc, Laure, additional, Dominique, Stéphane, additional, Morisse-Pradier, Hélène, additional, Pramil, Stéphanie, additional, Thiberville, Luc, additional, Allou, Nathalie, additional, Enaud, Laurent, additional, Gachelin, Elsa, additional, Huchot, Eric, additional, Payet, Annabelle, additional, Perisson, Caroline, additional, Piyaraly, Saguiraly, additional, Valois, Sophie, additional, Herzog, Audrey, additional, Kessler, Romain, additional, Porzio, Michele, additional, Weiss, Laurence, additional, Beaumont, Laurence, additional, Brugiere, Olivier, additional, Colin, Sylvie, additional, Verdiere, de, additional, Cuquemelle, Elise, additional, De Miranda, Sandra, additional, Monem Hamid, Adbdul, additional, Parquin, François, additional, Picard, Clément, additional, Roux, Antoine, additional, Roy, Charlotte, additional, Bremont, François, additional, Didier, Alain, additional, Dupuis, Marion, additional, Faviez, Guillaume, additional, Labouret, Géraldine, additional, Mittaine, Marie, additional, Murris-Espin, Marlène, additional, Roditis, Léa, additional, Cosson, Laure, additional, Diot, Patrice, additional, Flament, Thomas, additional, Giraut, Charlotte, additional, Mankikian, Julie, additional, Arnouat, Baptiste, additional, Mousset, Gaétane, additional, Storni, Véronique, additional, Vigneron, Philippe, additional, Coirier-Duet, Emmanuelle, additional, and Gabsi, Asma, additional

Published
2021
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18. Panniculitis in a Woman With Opportunistic Pulmonary Coinfection by Pneumocystis jirovecii and Cryptococcus neoformans

Author

Tedbirt, Billal, Duval-Modeste, Anne-Benedicte, Courville, Philippe, Dominique, Stéphane, Vera, Pierre, Regaieg, Hamza, Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), and Normandie Université (NU)

Subjects
MESH: Humans, MESH: Middle Aged, MESH: Fluorodeoxyglucose F18, [SDV]Life Sciences [q-bio], MESH: Cryptococcosis, MESH: Cryptococcus neoformans, MESH: Opportunistic Infections, MESH: Positron Emission Tomography Computed Tomography, MESH: Female, MESH: Pneumocystis carinii, MESH: Coinfection, MESH: Treatment Outcome, MESH: Pneumonia, Pneumocystis
Abstract

International audience; A 56-year-old woman, with history of psoriasis well controlled on ustekinumab, underwent 18F-FDG PET/CT to explore first onset of histologically proven skin panniculitis of unknown origin. PET/CT showed high uptake in panniculitis lesions in limbs and in a lung opacity suggestive of pneumonia. Based on PET/CT findings, a bronchoalveolar lavage revealed pulmonary coinfection by Pneumocystis jirovecii and Cryptococcus neoformans. Thus, hematogenous dissemination of infection was suspected as etiology of panniculitis. She was treated with fluconazole and trimethoprim-sulfamethoxazole, leading to total resolution of skin lesions. Posttherapeutic PET/CT showed complete metabolic response of skin and pulmonary lesions.

Published
2021

19. Nebulised liposomal-amphotericin-B as maintenance therapy in ABPA: a randomised, multicentre, trial

Author

Godet, Cendrine, Couturaud, Francis, Marchand-Adam, Sylvain, Pison, Christophe, Gagnadoux, Frédéric, Blanchard, Elodie, Taillé, Camille, Philippe, Bruno, Hirschi, Sandrine, Andréjak, Claire, Bourdin, Arnaud, Chenivesse, Cécile, Dominique, Stéphane, Bassinet, Laurence, Murris-Espin, Marlène, Rivière, Frédéric, Garcia, Gilles, Caillaud, Denis, Blanc, François-Xavier, Goupil, François, Bergeron, Anne, Gondouin, Anne, Frat, Jean-Pierre, Flament, Thomas, Camara, Boubou, Priou, Pascaline, Brun, Anne-Laure, Laurent, François, Ragot, Stéphanie, Cadranel, Jacques, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience; Background In allergic bronchopulmonary aspergillosis (ABPA), prolonged nebulised antifungal treatment may be a strategy for maintaining remission. Methods We performed a randomised, single-blind, clinical trial in 30 centres. Patients with controlled ABPA after a 4-month attack treatment (corticosteroids and itraconazole) were randomly assigned to nebulised liposomal-amphotericin-B or placebo for 6 months. The primary outcome was occurrence of a first severe clinical exacerbation within 24 months following randomisation. Secondary outcomes included the median time-to-first severe clinical exacerbation, number of severe clinical exacerbations per patient, ABPA-related biological parameters. Results Among 174 enrolled patients with ABPA from March 2015 through July 2017, 139 were controlled after 4-month attack treatment and were randomised. The primary outcome occurred in 33 (50.8%) of 65 patients in nebulised liposomal-amphotericin-B group and 38 (51.3%) of 74 in placebo group (absolute difference −0.6%, 95% CI −16.8% to +15.6%, odds ratio 0.98, 95% CI 0.50 to 1.90; p=0.95). The median time-to-first severe clinical exacerbation was longer in liposomal-amphotericin-B group, 337 days (IQR, 168 to 476) versus 177 (64 to 288). At the end of maintenance therapy, total immunoglobulin-E and Aspergillus precipitins were significantly decreased in nebulised liposomal-amphotericin-B group. Conclusions In ABPA, maintenance therapy using nebulised liposomal-amphotericin-B did not reduce the risk of severe clinical exacerbation. The presence of some positive secondary outcomes creates clinical equipoise for further research.

Published
2021

21. Effect of one-year lumacaftor–ivacaftor treatment on glucose tolerance abnormalities in cystic fibrosis patients

Author

Misgault, Bastien, Chatron, Eva, Reynaud, Quitterie, Touzet, Sandrine, Abely, Michel, Melly, Laurent, Dominique, Stéphane, Troussier, Françoise, Ronsin-Pradel, Olivia, Gerardin, Michèle, Mankikian, Julie, Cosson, Laure, Chiron, Raphael, Bounyar, Leila, Porzio, Michel, Durieu, Isabelle, Weiss, Laurence, Kessler, Romain, and Kessler, Laurence

Published
2020
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22. Large Granular Lymphocyte Leukemia and Precapillary Pulmonary Hypertension

Author

Cherel, Brieuc, primary, Humbert, Marc, additional, LeBlanc, Francis R., additional, Zambello, Renato, additional, Hamidou, Mohamed, additional, Lifermann, François, additional, Montani, David, additional, Leoncin, Matteo, additional, Decaux, Olivier, additional, Pastoret, Cedric, additional, Le Bourgeois, Amandine, additional, Dominique, Stéphane, additional, Chabanne, Céline, additional, Loughran, Thomas P., additional, and Lamy, Thierry, additional

Published
2020
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25. Real-Life Safety and Effectiveness of Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis

Author

Burgel, Pierre-Régis, primary, Munck, Anne, additional, Durieu, Isabelle, additional, Chiron, Raphaël, additional, Mely, Laurent, additional, Prevotat, Anne, additional, Murris-Espin, Marlene, additional, Porzio, Michele, additional, Abely, Michel, additional, Reix, Philippe, additional, Marguet, Christophe, additional, Macey, Julie, additional, Sermet-Gaudelus, Isabelle, additional, Corvol, Harriet, additional, Bui, Stéphanie, additional, Lemonnier, Lydie, additional, Dehillotte, Clémence, additional, Da Silva, Jennifer, additional, Paillasseur, Jean-Louis, additional, Hubert, Dominique, additional, Mounard, Julie, additional, Poulet, Claire, additional, Rames, Cinthia, additional, Person, Christine, additional, Troussier, Françoise, additional, Urban, Thierry, additional, Dalphin, Marie-Laure, additional, Dalphin, Jean-Claude, additional, Pernet, Didier, additional, Richaud-Thiriez, Bénédicte, additional, Fayon, Mickael, additional, Macey-Caro, Julie, additional, Campbell, Karine, additional, Laurans, Muriel, additional, Borderon, Corinne, additional, Heraud, Marie-Christine, additional, Labbé, André, additional, Montcouquiol, Sylvie, additional, Bassinet, Laurence, additional, Remus, Natascha, additional, Fanton, Annlyse, additional, Houzel-Charavel, Anne, additional, Huet, Frédéric, additional, Perez-Martin, Stéphanie, additional, Boldron-Ghaddar, Amale, additional, Scalbert, Manuela, additional, Camara, Boubou, additional, Llerena, Catherine, additional, Pin, Isabelle, additional, Quétant, Sébastien, additional, Cottereau, Aurélie, additional, Deschildre, Antoine, additional, Gicquello, Alice, additional, Perez, Thierry, additional, Stervinou-Wemeau, Lidwine, additional, Thumerelle, Caroline, additional, Wallaert, Benoit, additional, Wizla, Nathalie, additional, Languepin, Jane, additional, Ménétrey, Céline, additional, Dupuy-Grasset, Magalie, additional, Bazus, Lucie, additional, Buchs, Clelia, additional, Jubin, Virginie, additional, Werck-Gallois, Marie-Christine, additional, Mainguy, Catherine, additional, Perrin, Thomas, additional, Toutain-Rigolet, Agnès, additional, Durupt, Stéphane, additional, Reynaud, Quitterie, additional, Nove-Josserand, Raphaele, additional, Baravalle-Einaudi, Melisande, additional, Coltey, Bérangère, additional, Dufeu, Nadine, additional, Dubus, Jean-Christophe, additional, Stremler, Nathalie, additional, Caimmi, Davide, additional, Billon, Yves, additional, Derelle, Jocelyne, additional, Kieffer, Sébastien, additional, Pichon, Anne-Sophie, additional, Schweitzer, Cyril, additional, Tatopoulos, Aurélie, additional, Abbes, Sarah, additional, Bihouée, Tiphaine, additional, Danner-Boucher, Isabelle, additional, David, Valérie, additional, Haloun, Alain, additional, Tissot, Adrien, additional, Leroy, Sylvie, additional, Bailly-Piccini, Carole, additional, Clément, Annick, additional, Tamalet, Aline, additional, Burgel, Pierre-Régis, additional, Honoré, Isabelle, additional, Kanaan, Reem, additional, Martin, Clémence, additional, Bailly, Cécile, additional, Chédevergne, Frédérique, additional, De Blic, Jacques, additional, Fauroux, Brigitte, additional, Le Bourgeois, Murielle, additional, Delaisi, Bertrand, additional, Gérardin, Michèle, additional, Abély, Michel, additional, Ravoninjatovo, Bruno, additional, Belleguic, Chantal, additional, Desrues, Benoit, additional, Brinchault, Graziella, additional, Dagorne, Michel, additional, Deneuville, Eric, additional, Lefeuvre, Sylvaine, additional, Dirou, Anne, additional, Le Bihan, Jean, additional, Ramel, Sophie, additional, Dominique, Stéphane, additional, Payet, Annabelle, additional, Kessler, Romain, additional, Rosner, Vincent, additional, Weiss, Laurence, additional, de Miranda, Sandra, additional, Grenet, Dominique, additional, Hamid, Abdoul, additional, Picard, Clément, additional, Brémont, François, additional, Didier, Alain, additional, Labouret, Géraldine, additional, Mittaine, Marie, additional, Murris-Espin, Marlène, additional, Têtu, Laurent, additional, Cosson, Laure, additional, Giraut, Charlotte, additional, Henriet, Anne-Cécile, additional, Mankikian, Julie, additional, Marchand, Sophie, additional, Hugé, Sandrine, additional, Storni, Véronique, additional, and Coirier-Duet, Emmanuelle, additional

Published
2020
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26. Spectrum and Prognosis of Antineutrophil Cytoplasmic Antibody–associated Vasculitis-related Bronchiectasis: Data from 61 Patients

Author

Lhote, Raphael, primary, Chilles, Marie, additional, Groh, Matthieu, additional, Puéchal, Xavier, additional, Guilpain, Philippe, additional, Ackermann, Félix, additional, Amoura, Zahir, additional, Annesi-Maesano, Isabella, additional, Barba, Thomas, additional, Catherinot, Emilie, additional, Cohen-Aubart, Fleur, additional, Cohen, Pascal, additional, Cottin, Vincent, additional, Couderc, Louis-Jean, additional, De Boysson, Hubert, additional, Delbrel, Xavier, additional, Dominique, Stéphane, additional, Duhaut, Pierre, additional, Fain, Olivier, additional, Hachulla, Eric, additional, Hamidou, Mohamed, additional, Kahn, Jean-Emmanuel, additional, Legendre, Christophe, additional, Le Quellec, Alain, additional, Lhote, François, additional, Lifermann, François, additional, Mathian, Alexis, additional, Néel, Antoine, additional, Nunes, Hilario, additional, Subra, Jean-François, additional, Terrier, Benjamin, additional, Mouthon, Luc, additional, Diot, Elisabeth, additional, Guillevin, Loïc, additional, Brillet, Pierre-Yves, additional, and Tcherakian, Colas, additional

Published
2019
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30. Pleuroparenchymal fibroelastosis after allogeneic hematopoietic stem cell transplantation

Author

Bondeelle, Louise, primary, Gras, Julien, additional, Michonneau, David, additional, Houdouin, Véronique, additional, Hermet, Eric, additional, Blin, Nicolas, additional, Nicolini, Franck, additional, Michallet, Mauricette, additional, Dominique, Stéphane, additional, Huynh, Anne, additional, Leroy, Sylvie, additional, Socié, Gérard, additional, Thabut, Gabriel, additional, Reynaud-Gaubert, Martine, additional, Tazi, Abdellatif, additional, and Bergeron, Anne, additional

Published
2019
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34. The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

Author

Gentili, Matteo, Lahaye, Xavier, Nadalin, Francesca, Nader, Guilherme P.F., Puig Lombardi, Emilia, Herve, Solène, De Silva, Nilushi, Rookhuizen, Derek, Zueva, Elina, Goudot, Christel, Maurin, Mathieu, Bochnakian, Aurore, Amigorena, Sebastian, Piel, Matthieu, Fachinetti, Daniele, Manel, Nicolas, Beauvarlet, Jennifer, Bensadoun, Paul, Darbo, Elodie, Labrunie, Gaelle, Rousseau, Benoit, Richard, Elodie, Draskovic, Irena, Dupuy, Jean-William, Nath Das, Rabindra, Guédin, Aurore, Robert, Guillaume, Orange, François, Croce, Sabrina, Valesco, Valerie, Soubeyran, Pierre, Ryan, Kevin, Mergny, Jean-Louis, Mergny, Mojgan, Borie, Raphael, Bouvry, Diane, Cottin, Vincent, Gauvain, Clement, Cazes, Aurélie, Debray, Marie-Pierre, Cadranel, Jacques, Dieudé, Philippe, Degot, Tristan, Dominique, Stéphane, Gamez, Anne Sophie, Jaillet, Madeleine, Juge, Pierre-Antoine, Londono-Vallejo, Arturo, Mailleux, Arnaud, Mal, Herve, Boileau, Catherine, Ménard, Christelle, Nunes, Hilario, Prevot, Grégoire, Quetant, Sébastien, Revy, Patrick, Traclet, Julie, Wemeau-Stervinou, Lidwine, Wislez, Marie, Kannengiesser, Caroline, Crestani, Bruno, Immunité et cancer (U932), Institut Curie-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (LCQB), Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut Curie, Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Institut Bergonié - Département de médecine, Université Bordeaux Segalen - Bordeaux 2-Centre régional de lutte contre le cancer [CRLCC], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Centre Commun de Mesures Imagerie Cellulaire, Université de Lille, Sciences et Technologies, Telomeres and Cancer Laboratory, Centre Génomique Fonctionnelle Bordeaux [Bordeaux] (CGFB), Institut Polytechnique de Bordeaux-Université de Bordeaux Ségalen [Bordeaux 2], Acides Nucléiques : Régulations Naturelle et Artificielle (ARNA), Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'Anatomie Pathologique Générale, CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Plateforme de génétique moléculaire des cancers d'Aquitaine, Institut Bergonié - CRLCC Bordeaux, University of Glasgow, Régulation et dynamique des génomes, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de pneumologie [Avicenne], Hôpital Avicenne, Rétrovirus et Pathologie Comparée (RPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université Paris Diderot - Paris 7 (UPD7), Service de pneumologie et réanimation [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Tenon [APHP], Service de rhumatologie [Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 (UPD7), Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Département des Maladies Respiratoires [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Biologie de l'Os et du Cartilage : Régulations et Ciblages Thérapeutiques (BIOSCAR (UMR_S_1132 / U1132)), Dynamique de l'information génétique : bases fondamentales et cancer (DIG CANCER), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie-Centre National de la Recherche Scientifique (CNRS), Service de pneumologie B, Université Paris Descartes - Paris 5 (UPD5), CHU, Hôpital Larrey, Respiratory Disease, CHU Grenoble-Hôpital Michallon, Developpement Normal et Pathologique du Système Immunitaire, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Pneumologie et Immuno-Allergologie, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Theranoscan, Université Pierre et Marie Curie - Paris 6 (UPMC), Hôpital Bichat - Claude Bernard, Physiopathologie et Epidemiologie de l'Insuffisance Respiratoire, ANR-10-LABX-77, LABEX VRI, ANR-10-IDEX-0001-02 PSL∗, LABEX DCBIOL, ACTERIA FoundationACTERIA Foundation, Fondation Schlumberger pour l’Education et la Recherche, ECTZ36691, ANRSANRS, VIH2016126002, SidactionSidaction, DIM Biothérapies, 727408 STIMUNITY, European Research CouncilEuropean Research Council, French Ministry of Education, Research, and Technology, DCBIO 751735, Marie Skłodowska-Curie Individual Fellowship, ALTF 1298-2016, EMBO Long-term fellowship, ANR INNATENUCLEOTIDES, Fondation BMS, Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut Curie [Paris], Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Bergonié [Bordeaux], UNICANCER, UNICANCER-UNICANCER, Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Sorbonne Université, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Pierre et Marie Curie - Paris 6 (UPMC), Service de Pneumologie et Immuno-Allergologie [CHU LIlle], Pole Cardio-vasculaire et pulmonaire [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Biologie Cellulaire et Cancer, Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Sorbonne Université (SU), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-CHU Rouen

Subjects
0301 basic medicine, Male, [SDV]Life Sciences [q-bio], [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], chemistry.chemical_compound, Mice, 0302 clinical medicine, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, Transfection, interferon, nuclear envelope, Compartmentalization (psychology), Nucleotidyltransferases, Cell biology, Nuclear DNA, 3. Good health, centromere, Female, Adult, Satellite DNA, Guanosine, LINE, satellite DNA, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, DNA, Satellite, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, 03 medical and health sciences, Protein Domains, Animals, Humans, dendritic cells, 030304 developmental biology, Cell Nucleus, Innate immune system, DNA, IRF3, Immunity, Innate, Mice, Inbred C57BL, 030104 developmental biology, chemistry, cGAMP, 030217 neurology & neurosurgery, HeLa Cells, cGAS, STING
Abstract

Summary Cytosolic DNA activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS), an innate immune sensor pivotal in anti-microbial defense, senescence, auto-immunity, and cancer. cGAS is considered to be a sequence-independent DNA sensor with limited access to nuclear DNA because of compartmentalization. However, the nuclear envelope is a dynamic barrier, and cGAS is present in the nucleus. Here, we identify determinants of nuclear cGAS localization and activation. We show that nuclear-localized cGAS synthesizes cGAMP and induces innate immune activation of dendritic cells, although cGAMP levels are 200-fold lower than following transfection with exogenous DNA. Using cGAS ChIP-seq and a GFP-cGAS knockin mouse, we find nuclear cGAS enrichment on centromeric satellite DNA, confirmed by imaging, and to a lesser extent on LINE elements. The non-enzymatic N-terminal domain of cGAS determines nucleo-cytoplasmic localization, enrichment on centromeres, and activation of nuclear-localized cGAS. These results reveal a preferential functional association of nuclear cGAS with centromeres., Graphical Abstract, Highlights • Nuclear-localized cGAS activates a cellular innate immune response • Nuclear cGAS is 200-fold less active toward self-DNA than exogenous cytosolic DNA • Nuclear cGAS is enriched on centromeric satellite and LINE DNA repeats • The non-enzymatic N-terminal of cGAS determines nuclear localization and activity, cGAS is a well-established innate immune sensor of cytosolic DNA, but its presence in the nucleus is poorly understood. Gentili et al. find that nuclear cGAS is active and enriched on centromeres and LINE DNA repeats. Nuclear-cytoplasmic distribution, centromere association, and nuclear activation are determined by its non-enzymatic N-terminal domain.

Published
2019

35. Spectrum and Prognosis of Antineutrophil Cytoplasmic Antibody-associated Vasculitis-related Bronchiectasis: Data from 61 Patients.

Author

Lhote, Raphael, Chilles, Marie, Groh, Matthieu, Puéchal, Xavier, Guilpain, Philippe, Ackermann, Félix, Amoura, Zahir, Annesi-Maesano, Isabella, Barba, Thomas, Catherinot, Emilie, Cohen-Aubart, Fleur, Cohen, Pascal, Cottin, Vincent, Couderc, Louis-Jean, De Boysson, Hubert, Delbrel, Xavier, Dominique, Stéphane, Duhaut, Pierre, Fain, Olivier, and Hachulla, Eric

Published
2020
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36. Vinblastine chemotherapy in adult patients with langerhans cell histiocytosis: a multicenter retrospective study

Author

Tazi, Abdellatif, primary, Lorillon, Gwenaël, additional, Haroche, Julien, additional, Neel, Antoine, additional, Dominique, Stéphane, additional, Aouba, Achille, additional, Bouaziz, Jean-David, additional, de Margerie-Melon, Constance, additional, Bugnet, Emmanuelle, additional, Cottin, Vincent, additional, Comont, Thibault, additional, Lavigne, Christian, additional, Kahn, Jean-Emmanuel, additional, Donadieu, Jean, additional, and Chevret, Sylvie, additional

Published
2017
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37. In vivo probe-confocal laser endomicroscopy in amiodarone-related pneumonia

Author

Salaün, Mathieu, Roussel, Francis, Bourg Heckly, Genevieve, Vever-Bizet, Christine, Dominique, Stéphane, Genevois, Anne, Jounieaux, Vincent, Zalcman, Gérard, Bergot, Emmanuel, Vergnon, Jean-Michel, Thiberville, Luc, Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Laboratoire Jean PERRIN, Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Service d'imagerie médicale [CHU Rouen], Service de Pneumologie et Réanimation, CHU Amiens-Picardie, Centre de recherche clinique [CHU Caen] (CRC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER, Service de pneumologie [CHU Caen], Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Pneumologie et Oncologie thoracique [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-CHU Rouen, Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Pneumologie [Saint-Etienne], CHU Saint-Etienne, and Breton, Céline

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2013

38. Extrathoracic investigation in adult patients with isolated pulmonary langerhans cell histiocytosis

Author

Tazi, Abdellatif, primary, de Margerie-Mellon, Constance, additional, Vercellino, Laetitia, additional, Naccache, Jean Marc, additional, Fry, Stéphanie, additional, Dominique, Stéphane, additional, Jouneau, Stéphane, additional, Lorillon, Gwenaël, additional, Bugnet, Emmanuelle, additional, Chiron, Raphael, additional, Wallaert, Benoit, additional, Valeyre, Dominique, additional, and Chevret, Sylvie, additional

Published
2016
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39. Outcome of anti-PL12 positive patients with antisynthetase syndrome.[Profil évolutif du syndrome des antisynthétases avec anticorps anti-PL12]

Author

Marie, Isabelle, Josse, Séverine, Decaux, Olivier, Dominique, Stéphane, Landron, Cédric, Roblot, Pascal, Jouneau, Stéphane, Vittecoq, Olivier, Jouen, Fabienne, Service de Médecine Interne [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Service de Médecine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes], CHU Pontchaillou [Rennes], Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Service de Médecine Interne, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Service de rhumatologie [CHU Rouen], Laboratoire d'immunologie et biothérapies [Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, and Le Corre, Morgane

Subjects
MESH: Myositis, MESH: Alanine-tRNA Ligase, MESH: Humans, MESH: Middle Aged, [SDV.CAN] Life Sciences [q-bio]/Cancer, MESH: Autoantibodies, MESH: Retrospective Studies, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Female, MESH: Male, MESH: Prognosis
Abstract

International audience; OBJECTIVES: The aim of the present study was to assess the outcome in anti-PL12 patients with antisynthetase syndrome (ASS). METHODS: The medical records of anti-PL12 (n=5) patients with ASS were retrospectively analyzed without prior selection. To exclude false-positive patients, we included patients who were successively tested positive for anti-PL12 antibody at least twice by immunodot and/or Western blot. RESULTS: Anti-PL12 patients experienced: myositis (n=2), Raynaud's phenomenon (n=2), mechanic's hands (n=1), joint impairment (n=4), digestive involvement (n=2), and interstitial lung disease (ILD) (n=4). The two patients with myositis exhibited deterioration of muscle manifestations despite therapy. As regards outcome of ILD, patients developed resolution (n=1), stabilization (n=1) or deterioration (n=2) of pulmonary status. One patient died of pyogenic pneumonia. CONCLUSION: Our series underscores that the presence of anti-PL12 antibody is associated with a particular phenotype of ASS characterized by: (1) less frequent although severe/steroid refractory myositis; (2) less common mechanic's hands and calcinosis cutis; (3) both frequent and severe ILD. Taken together, our findings suggest that PM/DM patients should routinely undergo the search for anti-PL12 antibody as this autoantibody appears to impact patients' prognosis. Furthermore, ILD patients with anti-PL12 antibody should routinely undergo clinical screening for underlying ASS.

Published
2013

42. The natural history of adult pulmonary Langerhans cell histiocytosis: a prospective multicentre study

Author

Tazi, Abdellatif, primary, de Margerie, Constance, additional, Naccache, Jean Marc, additional, Fry, Stéphanie, additional, Dominique, Stéphane, additional, Jouneau, Stéphane, additional, Lorillon, Gwenaël, additional, Bugnet, Emmanuelle, additional, Chiron, Raphael, additional, Wallaert, Benoit, additional, Valeyre, Dominique, additional, and Chevret, Sylvie, additional

Published
2015
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43. Distal lung elastic network alterations in pulmonary fibrosis, a prospective controlled study using in-vivo confocal endomicroscopy

Author

Salaün, Mathieu, Jounieaux, Vincent, Zalcman, Gérard, Genevois, Anne, Dominique, Stéphane, Roussel, Florian, Bourg-Heckly, Geneviève, Vever-Bizet, Christine, Lachkar, Samy, Hauss, Pierre-Alexandre, Bota, Suzanna, Thiberville, Luc, Breton, Céline, Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Service de Pneumologie et Réanimation, CHU Amiens-Picardie, Centre de recherche clinique [CHU Caen] (CRC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER, Service d'imagerie médicale [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen], Laboratoire Jean PERRIN, Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-CHU Rouen, and Hôpital Charles Nicolle [Rouen]-CHU Rouen

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

44. In vivo microimaging of the alveolar capillary network during alveoscopy

Author

Thiberville, Luc, Salaün, Mathieu, Hauss, Pierre-Alexandre, Lachkar, Samy, Dominique, Stéphane, Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), and Breton, Céline

Published
2009

45. In vivo confocal fluorescence endomicroscopy of lung cancer

Author

Thiberville, Luc, Salaün, Mathieu, Lachkar, Samy, Dominique, Stéphane, Moreno-Swirc, Sophie, Vever-Bizet, Christine, Bourg-Heckly, Geneviève, Breton, Céline, Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Laboratoire de Biophysique Moléculaire Cellulaire et Tissulaire (BIOMOCETI), Université Paris 13 (UP13)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physicochimie biomoléculaire et cellulaire (LPBC), Programme Hospitalier de Recherche Clinique 2007, French ministry of Health, - Canceropole Nord Ouest , Lille, France- Institut National du Cancer, (Grant INCa-Lilly # 0612-3D1317-31), Boulogne Billancourt, France- Association pour le traitement à Domicile de l'Insuffisance Respiratoire (ADIR), Rouen, France., Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-CHU Rouen, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris 13 (UP13)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Abstract

International audience; With recent advances in computer and optics engineering, diagnostic endoscopy of the respiratory tract has now entered the era of microscopic imaging.Fibered confocal fluorescence microscopy (FCFM) is based on the principle of confocal microscopy, where the microscope objective has been replaced by a thin fiberoptic probe. FCFM has a lateral resolution of 3µm, a field of view of 600 µm and produces real-time imaging at 9 frames per second in contact with the probe tip. FCFM has the capability to image in real time the epithelial and subepithelial layers of the proximal bronchial tree, as well as the more distal parts of the lungs, from the terminal bronchioles down to the alveolar ducts and sacs. Potential applications of FCFM include « optical biopsy » assessment of early bronchial cancers, bronchial wall remodelling evaluation, diffuse peripheral lung disease exploration as well as in-vivo diagnosis of peripheral lung nodules. The technique has also the potential to be coupled with fluorescence molecular imaging. This strategy may help in the future to enable early diagnosis, rapid typing of molecular markers and assessment of therapeutic outcome in many lung diseases. This paper reviews the capabilities and possible limitations of confocal microendoscopy for proximal and distal lung exploration with special focus on lung cancer imaging in-vivo. Introduction : Confocal microscopy allows in-vivo optical sectionning of cells and tissue with enhanced lateral and axial resolutions (1, 2). Translating the principles of confocal microscopy into the clinic for endomicroscopy is currently the subject of significant scientific efforts (1, 2), which recently ended in the availability of commercial systems for both animal (3-5) and human in vivo explorations (6-8).Confocal endomicroscopes aim at providing to the clinician « optical biopsies », i.e. in vivo microscopic imaging, of a living tissue during endoscopy (9, 10). Such systems have recently been applied to the in-vivo microscopic imaging of both the proximal (7) and distal respiratory systems (8). Current commercially available confocal endomicroscopy system for lung exploration (Cellvizio®, Mauna Kea Technologies, Paris, France) uses the principle of proximal scanning in which the illumination light scans the proximal part of a coherent fiber bundle or miniprobe. This bundle conducts the light back and forth from the imaged area at the tip of the miniprobe (11). This fiber bundle or catheter based system, also described as « fibered confocal fluorescent microscopy (FCFM) » uses very thin and flexible miniprobes (300µm to 2 mm in diameter) that can contain up to 30,000 compacted microfibers. Similar to conventional confocal microscopes, FCFM uses two rapidly moving mirrors to scan the microfibers across the coherent fiber bundle in a raster fashion. Each microfiber, which is scanned one at a time by the laser light, acts as a light delivery and collection system and is, in essence, its own pinhole. The main advantages of this design is the very small size and the flexibility of the probe that can reach the more distal part of the lungs (8), as well as the fast image collection speed that helps to avoid artifacts due to tissue movement. Specific miniprobes for bronchial and alveolar imaging have a diameter of 1mm that can enter the working channel of any adult bronchoscope. These miniprobes are devoid of distal optics and have a depth of focus of 0-50 µm, a lateral resolution of 3µm for a field of view of 600 x 600 µm. The system produces endomicroscopic imaging in real time at 9 to 12 frames / second. Two different wave lengths are currently available. The Cellvizio 488 nm is used for autofluorescence imaging of the respiratory tract as well as for fluorescein induced imaging of the GI tract (7, 8, 12). Another device at 660 nm excitation can be used for epithelial cell imaging after topical application of exogenous fluorophores such as methylene blue (13-15). The main limitations are related to the maximal imaging capabilities (30,000 pixels) which restrict the lateral resolution to the fiber intercore distance (3µm), and the fact that the focus point of the system cannot be adjusted. Interpretation of the data also relies on the fluorescence properties of the imaged tissue. Human In-vivo confocal microimaging of the normal lung using FCFM . FCFM imaging of the proximal bronchi. FCFM can easily be performed during a fiberoptic bronchoscopy under local anesthesia (7, 8) . The technique of in-vivo bronchial FCFM imaging is simple : the miniprobe is introduced into the 2mm working channel of the bronchoscope and the probe tip applied onto the bronchial mucosae under sight control. The depth of focus being 50 µm below the contact surface, the system can image the first layers of the bronchial subepithelial connective tissue, presumably the lamina densa and the lamina reticularis (7). At 488 nm excitation, FCFM produces very precise microscopic fluorescent images of the bronchial basement membrane zone (Figure 1). FCFM bronchial microimaging reveals a mat of large fibers mainly oriented along the longitudinal axis of the airways with crosslinked smaller fibers, as well as larger openings – 100µm to 200 µm - corresponding to the bronchial glands origins. In vivo, the technique also makes it possible to record high resolution images of small airways such as terminal bronchioles, which are recognizable by the presence of the helicoidal imprint of the smooth muscle on the inner part of the bronchiole. (7) Fluorescence properties of the bronchial mucosae at 488 nm excitation are determined by the concentration of various cellular and extracellular fluorophores, including the intracellular flavins, that could originate from the epithelial cells, and specific crosslinks of collagens and elastin present in the subepithelial areas (1, 16, 17). Microspectrometer experiments coupled with FCFM imaging, have clearly demonstrated that the main fluorescence signal emitted after 488nm excitation from both bronchial and alveolar human system originates from the elastin component of the tissue (7, 8, 18). Indead, flavin cellular autofluorescence appears too weak to allow imaging of the epithelial layer using 488nm FCFM without exogenous fluorophore (19). Similarly, the collagen fluorescence does not significantly affect the FCFM image produced at 488nm, the fluorescence yield of collagen at this wave length being at least one order of magnitude smaller than that of elastin. As a result, 488nm excitation FCFM specifically images the elastin respiratory network that is contained in the basement membrane of the proximal airways and participates to the axial backbone of the peripheral interstitial respiratory system. In the future, it is possible that a modified FCFM device using several wavelengths (20), or devices based on a multiphoton approach (2) may enable imaging of collagen, elastin and flavins simultaneously. Distal lung FCFM imaging in-vivo : from the distal bronchioles down to the lung acini. In the acinus, elastin is present in the axial backbone of the alveolar ducts and alveolar entrances, as well as in the external sheath of the extra-alveolar microvessels (21, 22). FCFM acinar imaging is easily obtained by pushing forward the probe a few centimeters after the endoscope is distally blocked into a sub-segmental bronchi. When progressing towards the more distal parts of the lungs, the entry into the alveolar space is obtained by penetration through the bronchiolar wall. Alveolar fluorescence imaging in active smokers dramatically differs from imaging in non-smokers. The alveolar areas of smokers are usually filled with highly fluorescent cells corresponding to alveolar fluorescent macrophages, the presence of which appears very specific of active smoking. (8). In situ alveolar microspectrometric measurements have been performed in active smokers, which evidenced that the main fluorophore contributing to the FCFM alveolar signal corresponds to the tobacco tar by itself, explaining this difference (8, 18). Potential clinical applications of bronchoalveolar confocal imaging. Preliminary studies have shown that per endoscopic FCFM could be used to study specific basement membrane remodeling alterations in benign or malignant / premalignant bronchial alterations (7). The FCFM microstructure of the bronchial walls underlying premalignant epithelia is significantly altered. In these precancerous conditions, the elastic fibered pattern of the lamina reticularis is absent or disorganized in almost every preinvasive lesions (Figure 1). This supports the hypothesis of an early degradation of the basement membrane components in preinvasive bronchial lesions. However, while this observation shed some light on the origin of the autofluorescence defect in precancerous bronchial lesions, the absence of epithelial cell visualisation does not allow the technique to differentiate between the different grades of progression of the precancerous bronchial lesions such as metaplasia / dysplasia / carcinoma in situ. In order to be successfully applied to the exploration of precancerous / cancerous bronchial epithelial layer, the FCFM technique would need to be coupled with the use of an exogenous non toxic fluorophore. Ex-vivo studies have shown that the resolution of the system is not a limitation for nuclear or cellular imaging (7, 8) . Exogenous fluorophores that could be activated at 488 nm such as Acriflavin - a putative mutagen agent - or fluorescein solution, which does not stain the nuclei (23) are not approved for intrabronchial use. Recently, Lane et al. have used a confocal microendoscope prototype at 488 nm excitation and topical physiological PH cresyl violet to provide cellular contrast in the bronchial epithelium both in-vitro and in-vivo (24). Methylene blue is a non toxic agent which is commonly used during bronchoscopy for the diagnostic of broncho-pleural fistulae. MB is also used in gastroenterology for chromo-endoscopic detection of precancerous lesions (25-27), as well as for in-vivo microscopic examination of the GI tract and bronchus using a novel endocytoscopic system (28, 29). MB is a potent fluorophore which enters the nuclei and reversibelly binds to the DNA, before being reabsorbed by the lymphatics. In order to give a fluorescent signal, MB needs to be excited around 660 nm, and is therefore accessible to FCFM intravital imaging using this excitation wave length. Preliminary study has demonstrated that Cellvizio 660 / topical methylene blue makes it possible to reproducibly image the epithelial layer of the main bronchi. Future studies using this technique could make it possible to differentiate normal, premalignant and malignant alterations at the microscopic level. If this strategy is successful, FCFM may become a very powerful technique for in vivo diagnostic of early malignant and premalignant conditions of the bronchial tree, allowing the analysis of both the epithelial and subepithelial layers during the same procedure. Coupled to electromagnetic navigation or radial EBUS, FCFM could also image microstructural and cellular patterns of peripheral solide lung nodules in-vivo at both 448nm and 660 nm (14, 15) (figure 2). Until now, confocal microendoscopy of the airways has only used endogenous autofluorescence or simple fluorescent contrast agents to visualize the in-vivo cellular and interstitial organization of the airways and distal lung parenchyma. In the future, using molecular contrast coumponds, it will be possible to extend the range of biomarkers that may be imaged. Pilot studies exploring this strategy have recently been published, that provided specific confocal imaging of molecular probes in precancerous conditions of the oral cavity ex-vivo (30) and of colonic dysplasia in-vivo (31). Coupled to FCFM, molecular imaging may help in the future to enable early diagnosis, rapid typing of molecular markers and assessment of therapeutic outcome in many lung diseases.

Published
2009

46. Analyse morphométique alvéolaire in-vivo chez le sujet sain

Author

Salaün, Mathieu, Bourg-Heckly, Geneviève, Roussel, Francis, Moreno-Swirc, Sophie, Vever-Bizet, Christine, Bota, Suzanna, Hauss, Pierre-Alexandre, Lachkar, Samy, Dominique, Stéphane, Thiberville, Luc, Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU), and Breton, Céline

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2009

47. [Aspergillosis and sarcoidosis]

Author

Lachkar, Sammy, Dominique, Stéphane, Thiberville, Luc, Nouvet, Georges, Genevois, Anne, Breton, Céline, Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Hôpital Charles Nicolle [Rouen], CHU Rouen, and Normandie Université (NU)-Normandie Université (NU)-CHU Rouen

Subjects
Adult, Male, Hemoptysis, Antifungal Agents, MESH: Humans, MESH: Middle Aged, Lung Diseases, Fungal, MESH: Hemoptysis, MESH: Sarcoidosis, Pulmonary, MESH: Adult, Middle Aged, MESH: Antifungal Agents, Embolization, Therapeutic, MESH: Lung Diseases, Fungal, MESH: Male, Immunocompromised Host, MESH: Embolization, Therapeutic, Sarcoidosis, Pulmonary, MESH: Immunocompromised Host, Aspergillosis, Humans, MESH: Aspergillosis
Abstract

International audience; INTRODUCTION: Diffuse fibrosing sarcoidosis represents an important predisposing factor for infection by Aspergillus sp. The clinical features and specific complications are illustrated by 3 case reports. BACKGROUND: Patients with chronic fibrosing sarcoidosis and cystic changes or cavitation in the upper lobes are the most prone to aspergillosis. Aspergilloma is the most common form and can be difficult to distinguish from chronic necrotising aspergillosis. Sarcoidosis with aspergillosis is associated with an increased incidence of respiratory failure and fatal haemoptysis. The 3 cases presented in this paper also illustrate the poor efficacy of oral antifungal drugs and bronchial embolisation. Surgery is often necessary but may be difficult on account of the extent of the lesions and poor respiratory function. VIEWPOINT: In the future the use of new drugs such as voriconazole and posaconazole may improve the prognosis of this complication. CONCLUSION: Aspergillosis represents a frequent complication of diffuse fibrosing sarcoidosis which warrants early detection and treatment on account of its poor prognosis.

Published
2007

48. Progressive multifocal leukoencephalopathy in patients with sarcoidosis

Author

Jamilloux, Yvan, primary, Néel, Antoine, additional, Lecouffe-Desprets, Marie, additional, Fèvre, Anne, additional, Kerever, Sebastien, additional, Guillon, Benoit, additional, Bouvry, Diane, additional, Varron, Loig, additional, Redares, Cécile, additional, Dominique, Stéphane, additional, Roux, Mareille, additional, Chapelon-Abric, Catherine, additional, Valeyre, Dominique, additional, Ducray, François, additional, Bernard, Claire, additional, Broussolle, Christiane, additional, Hamidou, Mohamed, additional, and Sève, Pascal, additional

Published
2014
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