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459 results on '"Dominici, C."'

5. Testosterone-mediated activation of androgenic signalling sustains in vitro the transformed and radioresistant phenotype of rhabdomyosarcoma cell lines

Author

Giannattasio, S., Megiorni, F., Di Nisio, V., Del Fattore, A., Fontanella, R., Camero, S., Antinozzi, C., Festuccia, C., Gravina, G. L., Cecconi, S., Dominici, C., Di Luigi, L., Ciccarelli, C., De Cesaris, P., Riccioli, A., Zani, B. M., Lenzi, A., Pestell, R. G., Filippini, A., Crescioli, C., Tombolini, V., and Marampon, F.

Published
2019
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10. Deuterium inventory in Tore Supra: Coupled carbon–deuterium balance

Author

Pégourié, B., Panayotis, S., Languille, P., Martin, C., Dittmar, T., Gauthier, E., Hatchressian, J.-C., Pascal, J.-Y., Roubin, P., Ruffe, R., Tsitrone, E., Vartanian, S., Wang, H., Beauté, A., Bouvet, J., Brosset, C., Bucalossi, J., Cabié, M., Caprin, E., Courtois, X., Dachicourt, R., Delchambre, E., Dominici, C., Douai, D., Ekedahl, A., Gunn, J.P., Hakola, A., Jacob, W., Khodja, H., Likonen, J., Linez, F., Litnovsky, A., Marandet, Y., Markelj, S., Martinez, A., Mayer, M., Meyer, O., Monier-Garbet, P., Moreau, P., Negrier, V., Oddon, P., Pardanaud, C., Pasquet, B., Pelicon, P., Petersson, P., Philipps, V., Possnert, G., Reiter, D., Roth, J., Roure, I., Rubel, M., Saint-Laurent, F., Samaille, F., and Vavpetič, P.

Published
2013
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18. Neuroblastoma: contemporary management

Author

Mullassery, D., Dominici, C., Jesudason, E.C., McDowell, H.P., and Losty, P.D.

Subjects
Neuroblastoma -- Diagnosis, Neuroblastoma -- Care and treatment, Neuroblastoma -- Development and progression
Published
2009

20. MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1

Author

Vescarelli, E., Gerini, G., Megiorni, F., Anastasiadou, E., Pontecorvi, P., Solito, L., De Vitis, C., Camero, S., Marchetti, Claudia, Mancini, R., Benedetti Panici, P., Dominici, C., Romano, Federica, Angeloni, A., Marchese, Cinzia, Ceccarelli, Simona, Marchetti C. (ORCID:0000-0001-7098-8956), Romano F., Marchese C., Ceccarelli S., Vescarelli, E., Gerini, G., Megiorni, F., Anastasiadou, E., Pontecorvi, P., Solito, L., De Vitis, C., Camero, S., Marchetti, Claudia, Mancini, R., Benedetti Panici, P., Dominici, C., Romano, Federica, Angeloni, A., Marchese, Cinzia, Ceccarelli, Simona, Marchetti C. (ORCID:0000-0001-7098-8956), Romano F., Marchese C., and Ceccarelli S.

Abstract

Background: Ovarian cancer (OC) is the most lethal gynecological malignancy and the second leading cause of cancer-related death in women. Treatment with PARP inhibitors (PARPi), such as Olaparib, has been recently introduced for OC patients, but resistance may occur and underlying mechanisms are still poorly understood. The aim of this study is to identify target genes within the tumor cells that might cause resistance to Olaparib. We focused on Neuropilin 1 (NRP1), a transmembrane receptor expressed in OC and correlated with poor survival, which has been also proposed as a key molecule in OC multidrug resistance. Methods: Using three OC cell lines (UWB, UWB-BRCA and SKOV3) as model systems, we evaluated the biological and molecular effects of Olaparib on OC cell growth, cell cycle, DNA damage and apoptosis/autophagy induction, through MTT and colony forming assays, flow cytometry, immunofluorescence and Western blot analyses. We evaluated NRP1 expression in OC specimens and cell lines by Western blot and qRT-PCR, and used RNA interference to selectively inhibit NRP1. To identify miR-200c as a regulator of NRP1, we used miRNA target prediction algorithms and Pearsons' correlation analysis in biopsies from OC patients. Then, we used a stable transfection approach to overexpress miR-200c in Olaparib-resistant cells. Results: We observed that NRP1 is expressed at high levels in resistant cells (SKOV3) and is upmodulated in partially sensitive cells (UWB-BRCA) upon prolonged Olaparib treatment, leading to poor drug response. Our results show that the selective inhibition of NRP1 is able to overcome Olaparib resistance in SKOV3 cells. Moreover, we demonstrated that miR-200c can target NRP1 in OC cells, causing its downmodulation, and that miR-200c overexpression is a valid approach to restore Olaparib sensitivity in OC resistant cells. Conclusions: These data demonstrate that miR-200c significantly enhanced the anti-cancer efficacy of Olaparib in drug-resistant OC cells

Published
2020

23. Age-dependent Prognostic Significance of N-myc Copy Number in Neuroblastoma1

Author

Tonini, G. P., primary, Badiali, M., additional, Cavazzana, A., additional, Di Martino, D., additional, Dominici, C., additional, Fontana, V., additional, Iolascon, A., additional, Lanino, E., additional, Basso, G., additional, Pession, A., additional, Raschellá, G., additional, Strigini, P., additional, Sansone, R., additional, and De Bernardi, B., additional

Published
1990
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24. Testosterone-mediated activation of androgenic signalling sustains in vitro the transformed and radioresistant phenotype of rhabdomyosarcoma cell lines

Author

Giannattasio, S., primary, Megiorni, F., additional, Di Nisio, V., additional, Del Fattore, A., additional, Fontanella, R., additional, Camero, S., additional, Antinozzi, C., additional, Festuccia, C., additional, Gravina, G. L., additional, Cecconi, S., additional, Dominici, C., additional, Di Luigi, L., additional, Ciccarelli, C., additional, De Cesaris, P., additional, Riccioli, A., additional, Zani, B. M., additional, Lenzi, A., additional, Pestell, R. G., additional, Filippini, A., additional, Crescioli, C., additional, Tombolini, V., additional, and Marampon, F., additional

Published
2018
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27. 3D Distribution of Tyrosine Hydroxylase, Vasopressin and Oxytocin Neurons in the Transparent Postnatal Mouse Brain

Author

Godefroy, D., Dominici, C., Hardin-Pouzet, H., Anouar, Y., Melik-Parsadaniantz, S., Rostène, W., Goazigo, A. Reaux-Le, Institut de la Vision, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuroplasticité des comportements de reproduction = Neuroplasticity of Reproductive Behaviors (NPS-11), Neurosciences Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), and HAL-UPMC, Gestionnaire

Subjects
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Abstract

International audience; Over the years, advances in immunohistochemistry techniques have been a critical step in detecting and mapping neuromodulatory substances in the central nervous system. The better quality and specificity of primary antibodies, new staining procedures and the spectacular development of imaging technologies have allowed such progress. Very recently, new methods permitting tissue transparency have been successfully used on brain tissues. In this work, we combined whole-mount immunostaining for tyrosine hydroxylase (TH), oxytocin (OXT) and arginine vasopressin (AVP), with iDISCO+ clearing method, light-sheet microscopy and semi automated counting of 3D-labelled neurons to obtain a 3D distribution of these neuronal populations in a 5-day postnatal (P5) mouse brain. Segmentation procedure and 3D reconstruction allowed us to map with high resolution TH staining the various catecholaminergic cell groups and their ascending and descending fiber pathways. We show that TH pathways are present in the whole P5 mouse brain, similar to what was observed in the adult rat brain.

Published
2017
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28. MULTICENTER, PROSPECTIVE, CONTROLLED DOUBLE-BLIND STUDY COMPARING FIB-19-01, A PHYTOTHERAPY TREATMENT FOR FIBROMYALGIA, TO A DIETARY SUPPLEMENT AND TO CONVENTIONAL TREATMENT IN PATIENTS SUFFERING FROM FIBROMYALGIA

Author

Bertin, P., Baron, D., Barmaki, M., Russ, I., Maindet-Dominici, C., Fardellone, Patrice, Ginies, P., Conrozier, T., Nizard, J., CHU Amiens-Picardie, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, FLAveur, VIsion et Comportement du consommateur (FLAVIC), Etablissement National d'Enseignement Supérieur Agronomique de Dijon (ENESAD)-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), Centre Hospitalier de Belfort (Service de Rhumatologie), CH Belfort-Montbéliard, Assistance aux Gestes et Applications THErapeutiques (AGATHE), Institut des Systèmes Intelligents et de Robotique (ISIR), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Annual European Congress of Rheumatology, Madrid, SPAIN, JUN 14-17, 2017; International audience; Background Current therapeutic modalities for fibromyalgia syndrome (FMS) do not provide satisfactory results to a high percentage of patients and new approaches have to be explored.Objectives This randomised, double-blind, controlled study was aimed to assess the efficacy and safety of adding a new treatment of herbal medicine, specifically developed to improve the quality of life of patients with FMS (Fib-19–01), to the current therapeutic regimen.Methods In this double-blind, placebo-controlled study, females with FMS, insufficiently improved by their current treatments, were randomised in one of the 3 following arms: Patients of arm 1 received Fib-19–01, 1 tablet twice a day. Those of arm 2 received a food supplement claimed to have analgesic properties (FSAP), in a double-blind way, and patients of arm 3 continued the previous treatment. without adding anything else (NoT). All continued the conventional treatment throughout the 6 months of follow-up. Inclusion criteria: women suffering from FMS (ACR criteria) with a Fibromyalgia Index Questionnaire FIQ >46. The primary endpoint was the change in FIQ score between baseline (Day 0) and month 6 (M6). Secondary Criteria included variation between D0 and M6 of the following scores: Pichot scale, Pittsburgh Sleep Quality Index (PSQI) index, SF-12 mental and social, SF-12 physical, HAD scales for depression and anxiety. Statistical analysis: Comparison intra-group (D0-M6) and intergroup on the ITT population.Results The ITT and per protocol populations were constituted of 101 and 75 patients. They were not statistically different and were in accordance with that expected (age 49, BMI 25, high percentage of antidepressant and anticonvulsant treatments). FIQ decrease throughout the follow-up was significant only in the Fib-19–01 group; (p

Published
2017
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30. Validation of bleeding classifications in coronary artery bypass grafting

Author

Brascia, D. (Debora), Reichart, D. (Daniel), Onorati, F. (Francesco), Perrotti, A. (Andrea), Ruggieri, V. G. (Vito G.), Bounader, K. (Karl), Verhoye, J. P. (Jean Philippe), Santarpino, G. (Giuseppe), Fischlein, T. (Theodor), Maselli, D. (Daniele), Dominici, C. (Carmelo), Mariscalco, G. (Giovanni), Gherli, R. (Riccardo), Rubino, A. S. (Antonino S.), De Feo, M. (Marisa), Bancone, C. (Ciro), Gatti, G. (Giuseppe), Santini, F. (Francesco), Dalén, M. (Magnus), Saccocci, M. (Matteo), Faggian, G. (Giuseppe), Tauriainen, T. (Tuomas), Kinnunen, E.-M. (Eeva-Maija), Nicolini, F. (Francesco), Gherli, T. (Tiziano), Rosato, S. (Stefano), Biancari, F. (Fausto), Brascia, D. (Debora), Reichart, D. (Daniel), Onorati, F. (Francesco), Perrotti, A. (Andrea), Ruggieri, V. G. (Vito G.), Bounader, K. (Karl), Verhoye, J. P. (Jean Philippe), Santarpino, G. (Giuseppe), Fischlein, T. (Theodor), Maselli, D. (Daniele), Dominici, C. (Carmelo), Mariscalco, G. (Giovanni), Gherli, R. (Riccardo), Rubino, A. S. (Antonino S.), De Feo, M. (Marisa), Bancone, C. (Ciro), Gatti, G. (Giuseppe), Santini, F. (Francesco), Dalén, M. (Magnus), Saccocci, M. (Matteo), Faggian, G. (Giuseppe), Tauriainen, T. (Tuomas), Kinnunen, E.-M. (Eeva-Maija), Nicolini, F. (Francesco), Gherli, T. (Tiziano), Rosato, S. (Stefano), and Biancari, F. (Fausto)

Abstract

Perioperative bleeding is a determinant of poor outcome in patients undergoing coronary artery bypass grafting (CABG), but there is a lack of adequate stratification of its severity. The ability of the European registry of Coronary Artery Bypass Grafting (E-CABG), Universal Definition of Perioperative Bleeding (UDPB), Study of Platelet Inhibition and Patient Outcomes (PLATO), Clopidogrel and Aspirin Optimal Dose Usage to Reduce Recurrent Events−Seventh Organization to Assess Strategies in Ischemic Syndromes (CURRENT-OASIS 7), Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q Wave Coronary Events (ESSENCE), and SafeTy and Efficacy of Enoxaparin in Percutaneous coronary intervention patients, an internationaL randomized Evaluation (STEEPLE) bleeding classifications to predict early mortality, stroke, acute kidney injury (AKI) stage 3, and deep sternal wound infection/mediastinitis was investigated in 3,730 patients from the prospective, multicentre E-CABG registry. Increasing grades of the E-CABG, UDPB, PLATO, and CURRENT-OASIS 7 classifications were associated with increasing risks of early mortality, had similar receiver-operating characteristic area under the curves (>0.7), and were predictive also when adjusted for EuroSCORE II. The E-CABG and UDPB classifications had satisfactory area under the curves (>0.6) in predicting stroke, AKI stage 3, and deep sternal wound infection/mediastinitis even when adjusted for EuroSCORE II. The PLATO and CURRENT-OASIS 7 classifications had similar predictive ability for stroke and AKI stage 3 as confirmed by multivariate analysis adjusted for EuroSCORE II but showed inferior ability in predicting severe wound infection compared to the E-CABG and UDPB classifications. The STEEPLE and ESSENCE classifications had a poor ability of predicting all these adverse events. Decision curve analysis showed a benefit of the E-CABG bleeding classification over the other classifications in predicting all adverse events. In concl

Published
2017

31. DEVELOPMENT OF A SPME-GC-MS BASED METHOD FOR ANALYSIS OF ORGANOCHLORINATED SMOKE AGENTS IN SOIL AND ITS APPLICATION ABOUT THE CHARACTERIZATION OF A FORMER MILITARY SITE

Author

Sassolini, A, Dominici, C, Saurini, M, Guidotti, M, Cenciarelli, O, Malizia, A, Ludovici, G, Carestia, M, Di Giovanni, D, Gabbarini, V, Gabriele, J, Bellecci, C, Palombi, L, and Gaudio, P

Subjects
pollution from military activity, Solid Phase Micro Extraction, Settore FIS/01 - Fisica Sperimentale, carbon tetrachloride, smoke agents, Solid Phase Micro Extraction, smoke agents, hexachloroethane, carbon tetrachloride, pollution from military activity, hexachloroethane
Published
2015

38. Noonan syndrome-like disorder with loose anagen hair: A second case with neuroblastoma

Author

Garavelli, L, Cordeddu, V, Errico, S, Bertolini, P, Street, M, Rosato, S, Pollazzon, M, Wischmeijer, A, Ivanovski, I, Daniele, P, Bacchini, E, Lombardi, A, Izzi, G, Biasucci, G, Del Rossi, C, Corradi, D, Cazzaniga, G, Dominici, C, Rossi, C, De Luca, A, Bernasconi, S, Riccardi, R, Legius, E, Tartaglia, M, Garavelli, Livia, Cordeddu, Viviana, Errico, Stefania, Bertolini, Patrizia, Street, Maria Elisabeth, Rosato, Simonetta, Pollazzon, Marzia, Wischmeijer, Anita, Ivanovski, Ivan, Daniele, Paola, Bacchini, Ermanno, Lombardi, Alfonsa Anna, Izzi, Giancarlo, Biasucci, Giacomo, Del Rossi, Carmine, Corradi, Domenico, Cazzaniga, Giovanni, Dominici, Carlo, Rossi, Cesare, De Luca, Alessandro, Bernasconi, Sergio, Riccardi, Riccardo, Legius, Eric, Tartaglia, Marco, Garavelli, L, Cordeddu, V, Errico, S, Bertolini, P, Street, M, Rosato, S, Pollazzon, M, Wischmeijer, A, Ivanovski, I, Daniele, P, Bacchini, E, Lombardi, A, Izzi, G, Biasucci, G, Del Rossi, C, Corradi, D, Cazzaniga, G, Dominici, C, Rossi, C, De Luca, A, Bernasconi, S, Riccardi, R, Legius, E, Tartaglia, M, Garavelli, Livia, Cordeddu, Viviana, Errico, Stefania, Bertolini, Patrizia, Street, Maria Elisabeth, Rosato, Simonetta, Pollazzon, Marzia, Wischmeijer, Anita, Ivanovski, Ivan, Daniele, Paola, Bacchini, Ermanno, Lombardi, Alfonsa Anna, Izzi, Giancarlo, Biasucci, Giacomo, Del Rossi, Carmine, Corradi, Domenico, Cazzaniga, Giovanni, Dominici, Carlo, Rossi, Cesare, De Luca, Alessandro, Bernasconi, Sergio, Riccardi, Riccardo, Legius, Eric, and Tartaglia, Marco

Abstract

Noonan-like syndrome with loose anagen hair (NSLH), also known as Mazzanti syndrome, is a RASopathy characterized by craniofacial features resembling Noonan syndrome, cardiac defects, cognitive deficits and behavioral issues, reduced growth generally associated with GH deficit, darkly pigmented skin, and an unique combination of ectodermal anomalies. Virtually all cases of NSLH are caused by an invariant and functionally unique mutation in SHOC2 (c.4A>G, p.Ser2Gly). Here, we report on a child with molecularly confirmed NSLH who developed a neuroblastoma, first suspected at the age 3 months by abdominal ultrasound examination. Based on this finding, scanning of the SHOC2 coding sequence encompassing the c.4A>G change was performed on selected pediatric cohorts of malignancies documented to occur in RASopathies (i.e., neuroblastoma, brain tumors, rhabdomyosarcoma, acute lymphoblastic, and myeloid leukemia), but failed to identify a functionally relevant cancer-associated variant. While these results do not support a major role of somatic SHOC2 mutations in these pediatric cancers, this second instance of neuroblastoma in NSLAH suggests a possible predisposition to this malignancy in subjects heterozygous for the c.4A>G SHOC2 mutation.

Published
2015

45. Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma

Author

Anna C. Berardi, Marsilio, S., Rofani, C., Salvucci, O., Altavista, P., Perla, F. M., Diomedi-Camassei, F., Uccini, S., Kokai, G., Landuzzi, L., Mcdowell, H. P., Dominici, C., A.C. Berardi, S. Marsilio, C. Rofani, O. Salvucci, P. Altavista, F.M. Perla, F. Diomedi-Camassei, S. Uccini, G. Kokai, L. Landuzzi, H.P. McDowell, and C. Dominici.

Subjects
Cell Line, Tumor, Eph-B, Humans, Ephrin-B2, Ephrin-B1, RNA, Messenger, Ligands, Ephrins, RHABDOMYOSARCOMA, EPHRIN, Receptors, Eph Family, Up-Regulation
Abstract

BACKGROUND: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. MATERIALS AND METHODS: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. RESULTS: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r = 0.97, p < 0.01) and EphB3 (r = 0.94, p < 0.05); overexpression of ephrin-B2 correlated with overexpression of EphB1 (r = 0.94, p < 0.05), EphB2 (r = 0.88, p < 0.01) and EphB4 (r = 0.76, p < 0.01). In alveolar tumours, no similar correlations were found. A correlation between EphB2 and EphB4 receptors was demonstrated in both tumour types, being positive in embryonal cases (r = 0.81, p < 0.01) and negative in alveolar (r = -1.00, p < 0.01). CONCLUSION: A global up-regulation of ephrin-B and EphB receptors in RMS tumours was found. The correlation between EphB2 and EphB4 receptors suggests a possible role for ephrin-B and EphB receptors in RMS development

Published
2008

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