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1. OCTAPUS: Empowering Next Generation Central Offices with Cross-Layer Network Intelligence Towards a Reconfigurable Data Plane

Author

Gatzianas, M., Kalfas, G., Vagionas, C., Vargemidou, M., Papadakis, A., Saliou, F., Theodoropoulou, E., Lyberopoulos, G., Piscione, P., Abdulwahed, A., Giardina, P., Gavrilut, V., Alsted, C., Gardes, F., Zeimpekis, I., Domínguez, T., Yu, X., Chakraborty, I., Atwi, H., Dris, S., Argyris, N., Bakopoulos, P., Petridou, S., Miliou, A., Pleros, N., Rannenberg, Kai, Editor-in-Chief, Soares Barbosa, Luís, Editorial Board Member, Carette, Jacques, Editorial Board Member, Tatnall, Arthur, Editorial Board Member, Neuhold, Erich J., Editorial Board Member, Stiller, Burkhard, Editorial Board Member, Stettner, Lukasz, Editorial Board Member, Pries-Heje, Jan, Editorial Board Member, Kreps, David, Editorial Board Member, Rettberg, Achim, Editorial Board Member, Furnell, Steven, Editorial Board Member, Mercier-Laurent, Eunika, Editorial Board Member, Winckler, Marco, Editorial Board Member, Malaka, Rainer, Editorial Board Member, Maglogiannis, Ilias, editor, Iliadis, Lazaros, editor, Karydis, Ioannis, editor, Papaleonidas, Antonios, editor, and Chochliouros, Ioannis, editor

Published
2024
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4. New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality

Author

Lin, John C, Spinella, Philip C., Fitzgerald, Julie C., Tucci, Marisa, Bush, Jenny L., Nadkarni, Vinay M., Thomas, Neal J., Weiss, Scott L., Fontela, P., Tucci, M., Dumistrascu, M., Skippen, P., Krahn, G., Bezares, E., Puig, G., Puig Ramos, A., Garcia, R., Villar, M., Bigham, M., Polanski, T., Latifi, S., Giebner, D., Anthony, H., Hume, J., Galster, A., Linnerud, L., Sanders, R., Hefley, G., Madden, K., Thompson, A., Shein, S., Gertz, S., Han, Y., Williams, T., Hughes Schalk, A., Chandler, H., Orioles, A., Zielinski, E., Doucette, A., Zebuhr, C., Wilson, T., Dimitriades, C., Ascani, J., Layburn, S., Valley, S., Markowitz, B., Terry, J., Morzov, R., Mcinnes, A., Mcarthur, J., Woods, K., Murkowski, K., Spaeder, M., Sharron, M., Wheeler, D., Beckman, E., Frank, E., Howard, K., Carroll, C., Nett, S., Jarvis, D., Patel, V., Higgerson, R., Christie, L., Typpo, K., Deschenes, J., Kirby, A., Uhl, T., Rehder, K., Cheifetz, I., Wrenn, S., Kypuros, K., Ackerman, K., Maffei, F., Bloomquist, G., Rizkalla, N., Kimura, D., Shah, S., Tigges, C., Su, F., Barlow, C., Michelson, K., Wolfe, K., Goodman, D., Campbell, L., Sorce, L., Bysani, K., Monjure, T., Evans, M., Totapally, B., Chegondi, M., Rodriguez, C., Frazier, J., Steele, L., Viteri, S., Costarino, A., Thomas, N., Spear, D., Hirshberg, E., Lilley, J., Rowan, C., Rider, C., Kane, J., Zimmerman, J., Greeley, C., Lin, J., Jacobs, R., Parker, M., Culver, K., Loftis, L., Jaimon, N., Goldsworthy, M., Diliberto, M., Alen, C., Gessouroun, M., Sapru, A., Lang, T., Alkhouli, M., Kamath, S., Friel, D., Daufeldt, J., Hsing, D., Carlo, C., Pon, S., Scimeme, J., Shaheen, A., Hassinger, A., Qiao, H., Giuliano, J., Tala, J., Vinciguerra, D., Fernandez, A., Carrero, R., Hoyos, P., Jaramillo, J., Posada, A., Izquiierdo, L., Pineres Olave, B. E., Donado, J., Dalmazzo, R., Rendich, S., Palma, L., Lapadula, M., Acuna, C., Cruces, P., De Clety, S. Clement, Dujardin, M., Berghe, C., Renard, S., Zurek, J., Steinherr, H., Mougkou, K., Critselis, E., Di Nardo, M., Picardo, S., Tortora, F., Rossetti, E., Fragasso, T., Cogo, Paola, Netto, R., Dagys, A., Gurskis, V., Kevalas, R., Neeleman, C., Lemson, J., Luijten, C., Wojciech, K., Pagowska Klimek, I., Szczepanska, M., Karpe, J., Nunes, P., Almeida, H., Rios, J., Vieira, M., Garcia Iniguez, J. P., Revilla, P., Urbano, J., Lopez Herce, J., Bustinza, A., Cuesta, A., Hofheinz, S., Rodriguez Nunez, A., Sanagustin, S., Gonzalez, E., Riaza, M., Piaya, R., Soler, P., Esteban, E., Laraudogoitia, J., Monge, C., Herrera, V., Granados, J., Gonzalez, C., Koroglu, T., Ozcelik, E., Baines, P., Plunkett, A., Davis, P., George, S., Tibby, S., Harris, J., Agbeko, R., Lampitt, R., Brierley, J., Peters, M., Jones, A., Dominguez, T., Thiruchelvam, T., Deep, A., Ridley, L., Bowen, W., Levin, R., Macleod, I., Gray, M., Hemat, N., Alexander, J., Ali, S., Pappachan, J., Mccorkell, J., Fortune, P., Macdonald, M., Hudnott, P., Suyun, Q., Singhi, S., Nallasamy, K., Lodha, R., Shime, N., Tabata, Y., Saito, O., Ikeyama, T., Kawasaki, T., Lum, L., Abidin, A., Kee, S., Tang, S., Jalil, R., Guan, Y., Yao, L., Lin, K., Ong, J., Salloo, A., Doedens, L., Mathivha, L., Reubenson, G., Moaisi, S., Pentz, A., Green, R., Schibler, A., Erickson, S., Mceneiry, J., Long, D., Dorofaeff, T., Coulthard, M., Millar, J., Delzoppo, C., Williams, G., Morritt, M., Watts, N., Beca, J., Sherring, C., and Bushell, T.

Subjects
Male, medicine.medical_specialty, Adolescent, Cross-sectional study, Multiple Organ Failure, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Prevalence, children, epidemiology, multiple organ dysfunction syndrome, severe sepsis, Pediatrics, Perinatology and Child Health, Critical Care and Intensive Care Medicine, 030204 cardiovascular system & hematology, Global Health, Intensive Care Units, Pediatric, Pediatrics, Article, Sepsis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Epidemiology, medicine, Humans, Hospital Mortality, Prospective Studies, 030212 general & internal medicine, Child, Intensive care medicine, Prospective cohort study, Septic shock, business.industry, Infant, Newborn, Infant, Perinatology and Child Health, Prognosis, medicine.disease, Clinical trial, Cross-Sectional Studies, Phenotype, Child, Preschool, Disease Progression, Female, Multiple organ dysfunction syndrome, business
Abstract

Copyright © 2016 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.Objectives: To describe the epidemiology, morbidity, and mortality of new or progressive multiple organ dysfunction syndrome in children with severe sepsis. Design: Secondary analysis of a prospective, cross-sectional, point prevalence study. Setting: International, multicenter PICUs. Patients: Pediatric patients with severe sepsis identified on five separate days over a 1-year period. Interventions: None. Measurements and Main Results: Of 567 patients from 128 PICUs in 26 countries enrolled, 384 (68%) developed multiple organ dysfunction syndrome within 7 days of severe sepsis recognition. Three hundred twenty-seven had multiple organ dysfunction syndrome on the day of sepsis recognition. Ninety-one of these patients developed progressive multiple organ dysfunction syndrome, whereas an additional 57 patients subsequently developed new multiple organ dysfunction syndrome, yielding a total proportion with severe sepsis-associated new or progressive multiple organ dysfunction syndrome of 26%. Hospital mortality in patients with progressive multiple organ dysfunction syndrome was 51% compared with patients with new multiple organ dysfunction syndrome (28%) and those with single-organ dysfunction without multiple organ dysfunction syndrome (10%) (p < 0.001). Survivors of new or progressive multiple organ dysfunction syndrome also had a higher frequency of moderate to severe disability defined as a Pediatric Overall Performance Category score of greater than or equal to 3 and an increase of greater than or equal to 1 from baseline: 22% versus 29% versus 11% for progressive, new, and no multiple organ dysfunction syndrome, respectively (p < 0.001). Conclusions: Development of new or progressive multiple organ dysfunction syndrome is common (26%) in severe sepsis and is associated with a higher risk of morbidity and mortality than severe sepsis without new or progressive multiple organ dysfunction syndrome. Our data support the use of new or progressive multiple organ dysfunction syndrome as an important outcome in trials of pediatric severe sepsis although efforts are needed to validate whether reducing new or progressive multiple organ dysfunction syndrome leads to improvements in more definitive morbidity and mortality endpoints.

Published
2017

7. FIRST-line support for Assistance in Breathing in Children (FIRST-ABC): a multicentre pilot randomised controlled trial of high-flow nasal cannula therapy versus continuous positive airway pressure in paediatric critical care

Author

Ramnarayan, P, Lister, P, Dominguez, T, Habibi, P, Edmonds, N, Canter, RR, Wulff, J, Harrison, DA, Mouncey, PM, and Peters, MJ

Subjects
Male, FEASIBILITY, Critical Care, United Kingdom Paediatric Intensive Care Society Study Group (PICS-SG), ACUTE VIRAL BRONCHIOLITIS, Continuous positive airway pressure, INFANTS, Pilot Projects, INTENSIVE-CARE, Intensive Care Units, Pediatric, NONINVASIVE VENTILATION, Critical Care Medicine, General & Internal Medicine, London, Cannula, Humans, Child, Critical Care Outcomes, 11 Medical and Health Sciences, Science & Technology, Paediatric critical care, Oxygen Inhalation Therapy, Infant, Emergency & Critical Care Medicine, MECHANICAL VENTILATION, High-flow nasal cannula therapy, Child, Preschool, Female, Life Sciences & Biomedicine, Non-invasive respiratory support
Abstract

Background Although high-flow nasal cannula therapy (HFNC) has become a popular mode of non-invasive respiratory support (NRS) in critically ill children, there are no randomised controlled trials (RCTs) comparing it with continuous positive airway pressure (CPAP). We performed a pilot RCT to explore the feasibility, and inform the design and conduct, of a future large pragmatic RCT comparing HFNC and CPAP in paediatric critical care. Methods In this multi-centre pilot RCT, eligible patients were recruited to either Group A (step-up NRS) or Group B (step-down NRS). Participants were randomised (1:1) using sealed opaque envelopes to either CPAP or HFNC as their first-line mode of NRS. Consent was sought after randomisation in emergency situations. The primary study outcomes were related to feasibility (number of eligible patients in each group, proportion of eligible patients randomised, consent rate, and measures of adherence to study algorithms). Data were collected on safety and a range of patient outcomes in order to inform the choice of a primary outcome measure for the future RCT. Results Overall, 121/254 eligible patients (47.6%) were randomised (Group A 60%, Group B 44.2%) over a 10-month period (recruitment rate for Group A, 1 patient/site/month; Group B, 2.8 patients/site/month). In Group A, consent was obtained in 29/33 parents/guardians approached (87.9%), while in Group B 84/118 consented (71.2%). Intention-to-treat analysis included 113 patients (HFNC 59, CPAP 54). Most reported adverse events were mild/moderate (HFNC 8/59, CPAP 9/54). More patients switched treatment from HFNC to CPAP (Group A: 7/16, 44%; Group B: 9/43, 21%) than from CPAP to HFNC (Group A: 3/13, 23%; Group B: 5/41, 12%). Intubation occurred within 72 h in 15/59 (25.4%) of HFNC patients and 10/54 (18.5%) of CPAP patients (p = 0.38). HFNC patients experienced fewer ventilator-free days at day 28 (Group A: 19.6 vs. 23.5; Group B: 21.8 vs. 22.2). Conclusions Our pilot trial confirms that, following minor changes to consent procedures and treatment algorithms, it is feasible to conduct a large national RCT of non-invasive respiratory support in the paediatric critical care setting in both step-up and step-down NRS patients. Trial registration clinicaltrials.gov, NCT02612415. Registered on 23 November 2015.

Published
2018

8. Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis

Author

Thakkar, Rajan K., primary, Weiss, Scott L., additional, Fitzgerald, Julie C., additional, Keele, Luke, additional, Thomas, Neal J., additional, Nadkarni, Vinay M., additional, Muszynski, Jennifer A., additional, Hall, Mark W., additional, Fontela, P., additional, Tucci, M., additional, Dumistrascu, M., additional, Skippen, P., additional, Krahn, G., additional, Bezares, E., additional, Puig, G., additional, Puig-Ramos, A., additional, Garcia, R., additional, Villar, M., additional, Bigham, M., additional, Polanski, T., additional, Latifi, S., additional, Giebner, D., additional, Anthony, H., additional, Hume, J., additional, Galster, A., additional, Linnerud, L., additional, Sanders, R., additional, Hefley, G., additional, Madden, K., additional, Thompson, A., additional, Shein, S., additional, Gertz, S., additional, Han, Y., additional, Williams, T., additional, Hughes-Schalk, A., additional, Chandler, H., additional, Orioles, A., additional, Zielinski, E., additional, Doucette, A., additional, Zebuhr, C., additional, Wilson, T., additional, Dimitriades, C., additional, Ascani, J., additional, Layburn, S., additional, Valley, S., additional, Markowitz, B., additional, Terry, J., additional, Morzov, R., additional, Mcinnes, A., additional, McArthur, J., additional, Woods, K., additional, Murkowski, K., additional, Spaeder, M., additional, Sharron, M., additional, Wheeler, D., additional, Beckman, E., additional, Frank, E., additional, Howard, K., additional, Carroll, C., additional, Nett, S., additional, Jarvis, D., additional, Patel, V., additional, Higgerson, R., additional, Christie, L., additional, Typpo, K., additional, Deschenes, J., additional, Kirby, A., additional, Uhl, T., additional, Rehder, K., additional, Cheifetz, I., additional, Wrenn, S., additional, Kypuros, K., additional, Ackerman, K., additional, Maffei, F., additional, Bloomquist, G., additional, Rizkalla, N., additional, Kimura, D., additional, Shah, S., additional, Tigges, C., additional, Su, F., additional, Barlow, C., additional, Michelson, K., additional, Wolfe, K., additional, Goodman, D., additional, Campbell, L., additional, Sorce, L., additional, Bysani, K., additional, Monjure, T., additional, Evans, M., additional, Totapally, B., additional, Chegondi, M., additional, Rodriguez, C., additional, Frazier, J., additional, Steele, L., additional, Viteri, S., additional, Costarino, A., additional, Thomas, N., additional, Spear, D., additional, Hirshberg, E., additional, Lilley, J., additional, Rowan, C., additional, Rider, C., additional, Kane, J., additional, Zimmerman, J., additional, Greeley, C., additional, Lin, J., additional, Jacobs, R., additional, Parker, M., additional, Culver, K., additional, Loftis, L., additional, Jaimon, N., additional, Goldsworthy, M., additional, Fitzgerald, J., additional, Weiss, S., additional, Nadkarni, V., additional, Bush, J., additional, Diliberto, M., additional, Allen, C., additional, Gessouroun, M., additional, Sapru, A., additional, Lang, T., additional, Alkhouli, M., additional, Kamath, S., additional, Friel, D., additional, Daufeldt, J., additional, Hsing, D., additional, Carlo, C., additional, Pon, S., additional, Scimeme, J., additional, Shaheen, A., additional, Hassinger, A., additional, Qiao, H., additional, Giuliano, J., additional, Tala, J., additional, Vinciguerra, D., additional, Fernandez, A., additional, Carrero, R., additional, Hoyos, P., additional, Jaramillo, J., additional, Posada, A., additional, Izquiierdo, L., additional, Olave, B.E. Piñeres, additional, Donado, J., additional, Dalmazzo, R., additional, Rendich, S., additional, Palma, L., additional, Lapadula, M., additional, Acuna, C., additional, Cruces, P., additional, De Clety, S. Clement, additional, Dujardin, M., additional, Berghe, C., additional, Renard, S., additional, Zurek, J., additional, Steinherr, H., additional, Mougkou, K., additional, Critselis, E., additional, Di Nardo, M., additional, Picardo, S., additional, Tortora, F., additional, Rossetti, E., additional, Fragasso, T., additional, Cogo, P., additional, Netto, R., additional, Dagys, A., additional, Gurskis, V., additional, Kevalas, R., additional, Neeleman, C., additional, Lemson, J., additional, Luijten, C., additional, Wojciech, K., additional, Pagowska-Klimek, I., additional, Szczepanska, M., additional, Karpe, J., additional, Nunes, P., additional, Almeida, H., additional, Rios, J., additional, Vieira, M., additional, Iniguez, J. P. Garcia, additional, Revilla, P., additional, Urbano, J., additional, Lopez-Herce, J., additional, Bustinza, A., additional, Palacios, A., additional, Hofheinz, S., additional, Rodriguez-Nunez, A., additional, Sanagustin, S., additional, Gonzalez, E., additional, Riaza, M., additional, Piaya, R., additional, Soler, P., additional, Esteban, E., additional, Laraudogoitia, J., additional, Monge, C., additional, Herrera, V., additional, Granados, J., additional, Gonzalez, C., additional, Koroglu, T., additional, Ozcelik, E., additional, Baines, P., additional, Plunkett, A., additional, Davis, P., additional, George, S., additional, Tibby, S., additional, Harris, J., additional, Agbeko, R., additional, Lampitt, R., additional, Brierley, J., additional, Peters, M., additional, Jones, A., additional, Dominguez, T., additional, Thiruchelvam, T., additional, Deep, A., additional, Ridley, L., additional, Bowen, W., additional, Levin, R., additional, Macleod, I., additional, Gray, M., additional, Hemat, N., additional, Alexander, J., additional, Ali, S., additional, Pappachan, J., additional, McCorkell, J., additional, Fortune, P., additional, MacDonald, M., additional, Hudnott, P., additional, Suyun, Q., additional, Singhi, S., additional, Nallasamy, K., additional, Lodha, R., additional, Shime, N., additional, Tabata, Y., additional, Saito, O., additional, Ikeyama, T., additional, Kawasaki, T., additional, Lum, L., additional, Abidin, A., additional, Kee, S., additional, Tang, S., additional, Jalil, R., additional, Guan, Y., additional, Yao, L., additional, Lin, K., additional, Ong, J., additional, Salloo, A., additional, Doedens, L., additional, Mathivha, L., additional, Reubenson, G., additional, Moaisi, S., additional, Pentz, A., additional, Green, R., additional, Schibler, A., additional, Erickson, S., additional, McEneiry, J., additional, Long, D., additional, Dorofaeff, T., additional, Coulthard, M., additional, Millar, J., additional, Delzoppo, C., additional, Williams, G., additional, Morritt, M., additional, Watts, N., additional, Beca, J., additional, Sherring, C., additional, and Bushell, T., additional

Published
2019
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12. XX Semana de la Enseñanza de la Física

Author

Infante Luna, Esperanza Del Pilar, primary, Camacho Beltrán, Ángela Stella, additional, Manogue, Corinne A., additional, Monroy, Ignacio Alberto, additional, Varela, Karla, additional, Dray, Tevian, additional, Araujo, Juan Carlos, additional, Murcia Correa, Stefany, additional, Giraldo-Gallo, Paula, additional, Herrera, William, additional, Herrera, Edwin, additional, Avilán Vargas, Nicolás, additional, Castiblanco, Olga L., additional, Calderón Triana, Clara Lilia, additional, Cadavid, Doris, additional, Fonseca, Y., additional, Garibello, B., additional, Avilán, N., additional, Herreño, César, additional, Bóhorquez, O., additional, Ramos Bonilla, Mayra Alejandra, additional, López Segura, Claudia Patricia, additional, Calderón Vanegas, Wilson Camilo, additional, Morales, J., additional, Mejía, G., additional, Paredes, C., additional, Mancera, M., additional, Hernández, D., additional, García-Farieta, J.E., additional, Laserna, H., additional, Silva, S., additional, Hurtado, A., additional, Reyes, J., additional, Montaña, Daniel, additional, Cajamarca, D. A., additional, Villamil, S., additional, Munévar, E., additional, Calderón, G., additional, Buitrago, C., additional, Roncancio, M., additional, Espinosa, Camilo, additional, Padilla, Juan Nicolás, additional, Mera, D., additional, Ayala, C., additional, Santiesteban, Herley, additional, Pardo, C., additional, Hernández, Daniel Francisco, additional, Mancera, Mateo, additional, Rubiano, Joan, additional, Rodríguez, A., additional, Quiroga, Paola, additional, Salazar, Deisy, additional, Rivera, L., additional, Romero, J., additional, Hernández, A., additional, Quevedo, Y., additional, Infante, P., additional, García, María Fernanda, additional, Salas, J., additional, Ortega, C., additional, Gualteros, Erick, additional, Avilan, Nicolás, additional, Arias, D., additional, Roncancio, Edwin, additional, España, B., additional, Prieto, Diego, additional, Ramírez, Mayra, additional, Peña, L., additional, Rodríguez, R., additional, Hernandez, J., additional, Dominguez, T., additional, Farfán, C., additional, Guataquirá, José Efraín, additional, Torres, J. N., additional, Calderon, E., additional, Mendoza, I., additional, Rojas, G., additional, Vizcaíno, Diego Fernando, additional, and De la rosa, R., additional

Published
2018
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13. Prototype tests and description of a 60 tesla quasi-continuous magnet

Author

Sims, J.R., Dominguez, T., Northington, T.E., Pacheco, M.D., Rickel, D.G., Robinson, E.L., Rogers, J.D., and Schillig, J.B.

Subjects
Magnets -- Research, Business, Electronics, Electronics and electrical industries
Abstract

The National High Magnetic Field Laboratory has designed and will build a large bore, 60 tesla, 100 ms (quasi continuous) flat-top magnet for installation and use at Los Alamos. The magnet consists of eight concentric, resistive, solenoid coils fabricated from high strength, high conductivity copper supported by external stainless steel shells. Before each pulse the magnet is cooled to 77 K with liquid nitrogen. The energy for the magnet is provided through converter power supplies from a 1430 MVA, 24 kV alternating current energy storage generator. Plans for prototype tests of full scale portions of the magnet are discussed. A detailed description of the magnet is presented along with available information on fabrication methods to be employed in its manufacture.

Published
1994

14. Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs

Author

Giuliano, John S, Markovitz, Barry P., Brierley, Joe, Levin, Richard, Williams, Gary, Lum, Lucy Chai See, Dorofaeff, Tavey, Cruces, Pablo, Bush, Jenny L., Keele, Luke, Nadkarni, Vinay M., Thomas, Neal J., Fitzgerald, Julie C., Weiss, Scott L., Fontela, P., Tucci, M., Dumistrascu, M., Skippen, P., Krahn, G., Bezares, E., Puig, G., Puig Ramos, A., Garcia, R., Villar, M., Bigham, M., Polanski, T., Latifi, S., Giebner, D., Anthony, H., Hume, J., Galster, A., Linnerud, L., Sanders, R., Hefley, G., Madden, K., Thompson, A., Shein, S., Gertz, S., Han, Y., Williams, T., Hughes Schalk, A., Chandler, H., Orioles, A., Zielinski, E., Doucette, A., Zebuhr, C., Wilson, T., Dimitriades, C., Ascani, J., Layburn, S., Valley, S., Markowitz, B., Terry, J., Morzov, R., Mcinnes, A., Mcarthur, J., Woods, K., Murkowski, K., Spaeder, M., Sharron, M., Wheeler, D., Beckman, E., Frank, E., Howard, K., Carroll, C., Nett, S., Jarvis, D., Patel, V., Higgerson, R., Christie, L., Typpo, K., Deschenes, J., Kirby, A., Uhl, T., Rehder, K., Cheifetz, I., Wrenn, S., Kypuros, K., Ackerman, K., Maffei, F., Bloomquist, G., Rizkalla, N., Kimura, D., Shah, S., Tigges, C., Su, F., Barlow, C., Michelson, K., Wolfe, K., Goodman, D., Campbell, L., Sorce, L., Bysani, K., Monjure, T., Evans, M., Totapally, B., Chegondi, M., Rodriguez, C., Frazier, J., Steele, L., Viteri, S., Costarino, A., Thomas, N., Spear, D., Hirshberg, E., Lilley, J., Rowan, C., Rider, C., Kane, J., Zimmerman, J., Greeley, C., Lin, J., Jacobs, R., Parker, M., Culver, K., Loftis, L., Jaimon, N., Goldsworthy, M., Fitzgerald, J., Weiss, S., Nadkarni, V., Bush, J., Diliberto, M., Alen, C., Gessouroun, M., Sapru, A., Lang, T., Alkhouli, M., Kamath, S., Friel, D., Daufeldt, J., Hsing, D., Carlo, C., Pon, S., Scimeme, J., Shaheen, A., Hassinger, A., Qiao, H., Giuliano, J., Tala, J., Vinciguerra, D., Fernandez, A., Carrero, R., Hoyos, P., Jaramillo, J., Posada, A., Izquiierdo, L., Piñeres Olave, B. E., Donado, J., Dalmazzo, R., Rendich, S., Palma, L., Lapadula, M., Acuna, C., Cruces, P., Clement De Clety, S., Dujardin, M., Berghe, C., Renard, S., Zurek, J., Steinherr, H., Mougkou, K., Critselis, E., Di Nardo, M., Picardo, S., Tortora, F., Rossetti, E., Fragasso, T., Cogo, Paola, Netto, R., Dagys, A., Gurskis, V., Kevalas, R., Neeleman, C., Lemson, J., Luijten, C., Wojciech, K., Pagowska Klimek, I., Szczepanska, M., Karpe, J., Nunes, P., Almeida, H., Rios, J., Vieira, M., Revilla, P., Urbano, J., Lopez Herce, J., Bustinza, A., Cuesta, A., Hofheinz, S., Rodriguez Nunez, A., Sanagustin, S., Gonzalez, E., Riaza, M., Piaya, R., Soler, P., Esteban, E., Laraudogoitia, J., Monge, C., Herrera, V., Granados, J., Gonzalez, C., Koroglu, T., Ozcelik, E., Baines, P., Plunkett, A., Davis, P., George, S., Tibby, S., Harris, J., Agbeko, R., Lampitt, R., Brierley, J., Peters, M., Jones, A., Dominguez, T., Thiruchelvam, T., Deep, A., Ridley, L., Bowen, W., Levin, R., Macleod, I., Gray, M., Hemat, N., Alexander, J., Ali, S., Pappachan, J., Mccorkell, J., Fortune, P., Macdonald, M., Hudnott, P., Suyun, Q., Singhi, S., Nallasamy, K., Lodha, R., Shime, N., Tabata, Y., Saito, O., Ikeyama, T., Kawasaki, T., Lum, L., Abidin, A., Kee, S., Tang, S., Jalil, R., Guan, Y., Yao, L., Lin, K., Ong, J., Salloo, A., Doedens, L., Mathivha, L., Reubenson, G., Moaisi, S., Pentz, A., Green, R., Schibler, A., Erickson, S., Mceneiry, J., Long, D., Dorofaeff, T., Coulthard, M., Millar, J., Delzoppo, C., Williams, G., Morritt, M., Watts, N., Beca, J., Sherring, C., and Bushell, T.

Subjects
Male, Pediatrics, Cross-sectional study, shock, Critical Care and Intensive Care Medicine, Severity of Illness Index, 0302 clinical medicine, Prevalence, Hospital Mortality, Prospective Studies, 030212 general & internal medicine, Practice Patterns, Physicians', Child, Prospective cohort study, Pediatric intensive care unit, Perinatology and Child Health, Europe, Treatment Outcome, Child, Preschool, outcome, children, management, pediatric intensive care unit, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, medicine.medical_specialty, Adolescent, Critical Care, Intensive Care Units, Pediatric, Sepsis, 03 medical and health sciences, Intensive care, Severity of illness, medicine, Humans, Healthcare Disparities, business.industry, Organ dysfunction, Infant, Newborn, Infant, 030208 emergency & critical care medicine, Health Status Disparities, medicine.disease, United States, Clinical trial, Cross-Sectional Studies, Multivariate Analysis, Emergency medicine, business
Abstract

Copyright © 2016 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.Objectives: Pediatric severe sepsis remains a significant global health problem without new therapies despite many multicenter clinical trials. We compared children managed with severe sepsis in European and U.S. PICUs to identify geographic variation, which may improve the design of future international studies. Design: We conducted a secondary analysis of the Sepsis PRevalence, OUtcomes, and Therapies study. Data about PICU characteristics, patient demographics, therapies, and outcomes were compared. Multivariable regression models were used to determine adjusted differences in morbidity and mortality. Setting: European and U.S. PICUs. Patients: Children with severe sepsis managed in European and U.S. PICUs enrolled in the Sepsis PRevalence, OUtcomes, and Therapies study. Interventions: None. Measurements and Main Results: European PICUs had fewer beds (median, 11 vs 24; p < 0.001). European patients were younger (median, 1 vs 6 yr; p < 0.001), had higher severity of illness (median Pediatric Index of Mortality-3, 5.0 vs 3.8; p = 0.02), and were more often admitted from the ward (37% vs 24%). Invasive mechanical ventilation, central venous access, and vasoactive infusions were used more frequently in European patients (85% vs 68%, p = 0.002; 91% vs 82%, p = 0.05; and 71% vs 50%; p < 0.001, respectively). Raw morbidity and mortality outcomes were worse for European compared with U.S. patients, but after adjusting for patient characteristics, there were no significant differences in mortality, multiple organ dysfunction, disability at discharge, length of stay, or ventilator/vasoactive-free days. Conclusions: Children with severe sepsis admitted to European PICUs have higher severity of illness, are more likely to be admitted from hospital wards, and receive more intensive care therapies than in the United States. The lack of significant differences in morbidity and mortality after adjusting for patient characteristics suggests that the approach to care between regions, perhaps related to PICU bed availability, needs to be considered in the design of future international clinical trials in pediatric severe sepsis.

Published
2016

15. Comparison of Pediatric Severe Sepsis Managed in US and European ICUs

Author

Giuliano, J.S., Markovitz, B.P., Brierley, J., Levin, R., Williams, G., Lum, L.C.S., Dorofaeff, T., Cruces, P., Bush, J.L., Keele, L., Nadkarni, V.M., Thomas, N.J., Fitzgerald, J.C., Weiss, S.L., Fontela, P., Tucci, M., Dumistrascu, M., Skippen, P., Krahn, G., Bezares, E., Puig, G., Puig-Ramos, A., Garcia, R., Villar, M., Bigham, M., Polanski, T., Latifi, S., Giebner, D., Anthony, H., Hume, J., Galster, A., Linnerud, L., Sanders, R., Hefley, G., Madden, K., Thompson, A., Shein, S., Gertz, S., Han, Y., Williams, T., Hughes-Schalk, A., Chandler, H., Orioles, A., Zielinski, E., Doucette, A., Zebuhr, C., Wilson, T., Dimitriades, C., Ascani, J., Layburn, S., Valley, S., Markowitz, B., Terry, J., Morzov, R., McInnes, A., McArthur, J., Woods, K., Murkowski, K., Spaeder, M., Sharron, M., Wheeler, D., Beckman, E., Frank, E., Howard, K., Carroll, C., Nett, S., Jarvis, D., Patel, V., Higgerson, R., Christie, L., Typpo, K., Deschenes, J., Kirby, A., Uhl, T., Rehder, K., Cheifetz, I., Wrenn, S., Kypuros, K., Ackerman, K., Maffei, F., Bloomquist, G., Rizkalla, N., Kimura, D., Shah, S., Tigges, C., Su, F., Barlow, C., Michelson, K., Wolfe, K., Goodman, D., Campbell, L., Sorce, L., Bysani, K., Monjure, T., Evans, M., Totapally, B., Chegondi, M., Rodriguez, C., Frazier, J., Steele, L., Viteri, S., Costarino, A., Spear, D., Hirshberg, E., Lilley, J., Rowan, C., Rider, C., Kane, J., Zimmerman, J., Greeley, C., Lin, J., Jacobs, R., Parker, M., Culver, K., Loftis, L., Jaimon, N., Goldsworthy, M., Fitzgerald, J., Nadkarni, V., Bush, J., Diliberto, M., Alen, C., Gessouroun, M., Sapru, A., Lang, T., Alkhouli, M., Kamath, S., Friel, D., Daufeldt, J., Hsing, D., Carlo, C., Pon, S., Scimeme, J., Shaheen, A., Hassinger, A., Qiao, H., Giuliano, J., Tala, J., Vinciguerra, D., Fernandez, A., Carrero, R., Hoyos, P., Jaramillo, J., Posada, A., Izquiierdo, L., Piñeres Olave, B.E., Donado, J., Dalmazzo, R., Rendich, S., Palma, L., Lapadula, M., Acuna, C., Clement De Clety, S., Dujardin, M., Berghe, C., Renard, S., Zurek, J., Steinherr, H., Mougkou, K., Critselis, E., Di Nardo, M., Picardo, S., Tortora, F., Rossetti, E., Fragasso, T., Cogo, P., Netto, R., Dagys, A., Gurskis, V., Kevalas, R., Neeleman, C., Lemson, J., Luijten, C., Wojciech, K., Pagowska-Klimek, I., Szczepanska, M., Karpe, J., Nunes, P., Almeida, H., Rios, J., Vieira, M., Revilla, P., Urbano, J., Lopez-Herce, J., Bustinza, A., Cuesta, A., Hofheinz, S., Rodriguez-Nunez, A., Sanagustin, S., Gonzalez, E., Riaza, M., Piaya, R., Soler, P., Esteban-Torne E, Laraudogoitia, J., Monge, C., Herrera, V., Granados, J., Gonzalez, C., Koroglu, T., Ozcelik, E., Baines, P., Plunkett, A., Davis, P., George, S., Tibby, S., Harris, J., Agbeko, R., Lampitt, R., Peters, M., Jones, A., Dominguez, T., Thiruchelvam, T., Deep, A., Ridley, L., Bowen, W., Macleod, I., Gray, M., Hemat, N., Alexander, J., Ali, S., Pappachan, J., McCorkell, J., Fortune, P., MacDonald, M., Hudnott, P., Suyun, Q., Singhi, S., Nallasamy, K., Lodha, R., Shime, N., Tabata, Y., Saito, O., Ikeyama, T., Kawasaki, T., Lum, L., Abidin, A., Kee, S., Tang, S., Jalil, R., Guan, Y., Yao, L., Lin, K., Ong, J., Salloo, A., Doedens, L., Mathivha, L., Reubenson, G., Moaisi, S., Pentz, A., Green, R., Schibler, A., Erickson, S., McEneiry, J., Long, D., Coulthard, M., Millar, J., Delzoppo, C., Morritt, M., Watts, N., Beca, J., Sherring, C., and Bushell, T.

Published
2016

16. DI-060 Written patient information: analysing its quality

Author

Selvi-Sabater, P, primary, Leon-Villa, J, additional, Gorostiza-Frias, I, additional, Alonso-Dominguez, T, additional, Titos-Arcos, JC, additional, Manrsesa-Ramon, N, additional, Soria-Soto, M, additional, Sanchez-Catalcio, MDM, additional, Plaza-Aniorte, J, additional, and Garcia-Motos, C, additional

Published
2017
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17. CP-128 Analysis and evolution of spending on orphan drugs

Author

Selvi-Sabater, P, primary, Leon-Villar, J, additional, Alonso-Dominguez, T, additional, Espuny-Miró, A, additional, Titos-Arcos, JC, additional, Sanchez-Catalicio, MDM, additional, Aranda-Garcia, A, additional, Gorostiza-Frias, I, additional, Manresa-Ramon, N, additional, and Soria-Soto, M, additional

Published
2017
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18. OHP-021 Utilisation analisys of lenalidomide in multiple myeloma

Author

Selvi-Sabater, P, primary, Leon-Villar, J, additional, Soria-Soto, M, additional, Sanchez-Catalicio, MDM, additional, Gorostiza-Frias, I, additional, Titos-Arcos, JC, additional, Alonso-Dominguez, T, additional, Manresa-Ramon, N, additional, Plaza-Aniorte, J, additional, and Espuny-Miró, A, additional

Published
2017
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19. Identification and characterization of grapevine genetic resources maintained in Eastern European Collections

Author

Maul, E., Toepfer, R., Carka, F., Cornea, V., Crespan, M., Dallakyan, M., Andres Dominguez, T., Lorenzis, G., Dejeu, L., Goryslavets, S., Maria Stella Grando, Hovannisyan, N., Hudcovicova, M., Hvarleva, T., Ibanez, J., Kiss, E., Kocsis, L., Lacombe, T., Laucou, V., Maghradze, D., Maletic, E., Melyan, G., Mihaljevic, M. Z., Munoz-Organero, G., Musayev, M., Nebish, A., Popescu, C. F., Regner, F., Risovanna, V., Ruisa, S., Salimov, V., Savin, G., Schneider, A., Stajner, N., Ujmajuridze, L., Failla, O., Institut für Rebenzüchtung Geilweilerhof, Julius Kühn-Institut (JKI), Agricultural University of Tirana, Research and Practical Institute for Horticulture and Food Technologies, Centro di ricerca per la Viticoltura (CRAVIT), Department of Ecology and Nature Protection, University of Podlasie, Instituto Madrileño de Investigación y Desarrollo Rural, Agrario y Alimentario (IMIDRA), Università degli Studi di Milano [Milano] (UNIMI), Faculty of Horticulture, University of Agronomical Sciences and Veterinary Medicine, National Institute for Vine and Wine ‘Magarach’, Istituto Agrario di San Michele all'Adige (IASMA), Plant Production Research, AgroBioInstitute, Instituto de Ciencias de la Vid y el Vino - Institute of Grapevine and Wine Sciences, Partenaires INRAE, Institute of Genetics and Biotechnology, Szent István University, University of Pannonia, Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP), Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Institute of Horticulture, Viticulture and Oenology, Agricultural University of Georgia, Department of Viticulture and Enology [Zagreb], Faculty of Agriculture [Zagreb] (UNIZG), University of Zagreb-University of Zagreb, Academy of Viticulture and Wine-making, Azerbaijan National Academy of Sciences (ANAS), HBLAuBA Klosterneuburg, State Institute of Fruit-Growing, Azerbaijani Scientific Research Institute of Viticulture and Winemaking, Istituto di Virologia Vegetale, Università degli studi di Torino (UNITO), University of Ljubljana, and National Center for Grapevine and Fruit Tree Planting Material Propagation (AGRO)

Subjects
0106 biological sciences, Identification, biodiversity, grapevine, microsatellites, identification, documentation, germplasm preservation, Characterization, Documentation, 01 natural sciences, Germplasm preservation, 03 medical and health sciences, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Microsatellites, Genetic resources, 030304 developmental biology, 0303 health sciences, Biodiversity, Settore AGR/07 - GENETICA AGRARIA, Eastern Europe collection, Grapevine, 010606 plant biology & botany
Abstract

The Near East and the Caucasus regions are considered as gene and domestication centre for grapevine. In an earlier project “Conservation and Sustainable Use of Grapevine Genetic Resources in the Caucasus and Northern Black Sea Region” (2003-2007) it turned out that 2,654 accessions from autochthonous cultivars maintained by Armenia, Azerbaijan, Georgia, Moldova, Russian Federation and Ukraine in ten grapevine collections may belong to 1,283 cultivars. But trueness to type assessment by morphology and genetic fingerprinting still needed to be done. In COST Action FA1003 a first step in that direction was initiated. The following countries participated: Albania, Armenia, Austria, Azerbaijan, Bulgaria, Croatia, Georgia, Hungary, Latvia, Moldova, Romania, Slovakia, Slovenia and Ukraine. Mainly Vitis vinifera accessions (1098 samples) and 76 Vitis sylvestris individuals were analyzed by nine SSR-markers (VVS2, VVMD5, VVMD7, VVMD25, VVMD27, VVMD28, VVMD32, VrZag62, VrZag79). Cultivar identity confirmation/rejection was attempted for 306 genotypes/cultivars by comparison of the generated genetic profiles with international SSR-marker databases and ampelographic studies. The outcome proved unambiguously the necessity of morphologic description and photos (a) for comparison with bibliography, (b) for a clear and explicit definition of the cultivar and (c) the detection of sampling errors and misnomers. From the 1,098 analyzed accessions, 997 turned out to be indigenous to the participating countries. The remaining 101 accessions were Western European cultivars. The 997 fingerprints of indigenous accessions resulted in 658 unique profiles/cultivars. From these 353 (54 %) are only maintained in the countries of origin and 300 (46 %) unique genotypes exist only once in the Eastern European collections. For these 300 genotypes duplicate preservation needs to be initiated. In addition, the high ratio of non redundant genetic material of Eastern European origin suggests an immense unexplored diversity. Documentation of the entire information in the European Vitis Database will assist both germplasm maintenance and documentation of cultivar specific data., VITIS - Journal of Grapevine Research, Vol. 54 (2015): Vitis (Special Issue)

Published
2015

20. Acute kidney injury in pediatric severe sepsis : An independent risk factor for death and new disability

Author

Fitzgerald, Julie C., Basu, Rajit K., Akcan-Arikan, Ayse, Izquierdo, Ledys M., Piñeres Olave, Byron E., Hassinger, Amanda B., Szczepanska, Maria, Deep, Akash, Williams, Duane, Sapru, Anil, Roy, Jason A., Nadkarni, Vinay M., Thomas, Neal J., Weiss, Scott L., Furth, Susan, Fontela, P., Tucci, M., Dumistrascu, M., Skippen, P., Krahn, G., Bezares, E., Puig, G., Puig-Ramos, A., Garcia, R., Villar, M., Bigham, M., Polanski, T., Latifi, S., Giebne, D., Anthony, H., Hume, J., Galster, A., Linnerud, L., Sanders, R., Hefley, G., Madden, K., Thompson, A., Shein, S., Gertz, S., Han, Y., Hughes-Schalk, A., Chandler, H., Orioles, A., Zielinski, E., Doucette, A., Zebuhr, C., Wilson, T., Dimitriades, C., Ascani, J., Layburn, S., Valley, S., Markowitz, B., Terry, J., Morzov, R., Mcinnes, A., McArthur, J., Woods, K., Murkowski, K., Spaeder, M., Sharron, M., Wheeler, D., Beckman, E., Frank, E., Howard, K., Carroll, C., Nett, S., Jarvis, D., Patel, V., Higgerson, R., Christie, L., Typpo, K., Deschenes, J., Kirby, A., Uhl, T., Rehder, K., Cheifetz, I., Wrenn, S., Kypuros, K., Ackerman, K., Maffei, F., Bloomquist, G., Rizkalla, N., Kimura, D., Shah, S., Tigges, C., Su, F., Barlow, C., Michelson, K., Wolfe, K., Goodman, D., Campbell, L., Sorce, L., Bysani, K., Monjure, T., Evans, M., Totapally, B., Chegondi, M., Rodriguez, C., Frazier, J., Steele, L., Viteri, S., Costarino, A., Spear, D., Hirshberg, E., Lilley, J., Rowan, C., Rider, C., Kane, J., Zimmerman, J., Greeley, C., Lin, J., Jacobs, R., Parker, M., Culver, K., Loftis, L., Jaimon, N., Goldsworthy, M., Bush, J., Diliberto, M., Allen, C., Gessouroun, M., Lang, T., Alkhouli, M., Kamath, S., Friel, D., Daufeldt, J., Hsing, D., Carlo, C., Pon, S., Scimeme, J., Shaheen, A., Qiao, H., Giuliano, J., Tala, J., Vinciguerra, D., Fernandez, A., Carrero, R., Hoyos, P., Jaramillo, J., Posada, A., Izquiierdo, L., Donado, J., Dalmazzo, R., Rendich, S., Palma, L., Lapadula, M., Acuna, C., Cruces, P., Clement De Clety, S., Dujardin, M., Berghe, C., Renard, S., Zurek, J., Steinherr, H., Mougkou, K., Critselis, E., Di Nardo, M., Picardo, S., Tortora, F., Rossetti, E., Fragasso, T., Cogo, P., Netto, R., Dagys, A., Gurskis, V., Kevalas, R., Neeleman, C., Lemson, J., Luijten, C., Wojciech, K., Pagowska-Klimek, I., Karpe, J., Nunes, P., Almeida, H., Rios, J., Vieira, M., Garcia Iniguez, JP, Revilla, P., Urbano, J., Lopez-Herce, J., Bustinza, A., Palacios, A., Hofheinz, S., Rodriguez-Nunez, A., Sanagustin, S., Gonzalez, E., Riaza, M., Piaya, R., Soler, P., Esteban, E., Laraudogoitia, J., Monge, C., Herrera, V., Granados, J., Gonzalez, C., Koroglu, T., Ozcelik, E., Baines, P., Plunkett, A., Davis, P., George, S., Tibby, S., Harris, J., Agbeko, R., Lampitt, R., Brierley, J., Peters, M., Jones, A., Dominguez, T., Thiruchelvam, T., Ridley, L., Bowen, W., Levin, R., Macleod, I., Gray, M., Hemat, N., Alexander, J., Ali, S., Pappachan, J., McCorkell, J., Fortune, P., MacDonald, M., Hudnott, P., Suyun, Q., Singhi, S., Nallasamy, K., Lodha, R., Shime, N., Tabata, Y., Saito, O., Ikeyama, T., Kawasaki, T., Lum, L., Abidin, A., Kee, S., Tang, S., Jalil, R., Guan, Y., Yao, L., Lin, K., Ong, J., Salloo, A., Doedens, L., Mathivha, L., Reubenson, G., Moaisi, S., Pentz, A., Green, R., Schibler, A., Long, D., Fitzgerald, Julie C., Basu, Rajit K., Akcan-Arikan, Ayse, Izquierdo, Ledys M., Piñeres Olave, Byron E., Hassinger, Amanda B., Szczepanska, Maria, Deep, Akash, Williams, Duane, Sapru, Anil, Roy, Jason A., Nadkarni, Vinay M., Thomas, Neal J., Weiss, Scott L., Furth, Susan, Fontela, P., Tucci, M., Dumistrascu, M., Skippen, P., Krahn, G., Bezares, E., Puig, G., Puig-Ramos, A., Garcia, R., Villar, M., Bigham, M., Polanski, T., Latifi, S., Giebne, D., Anthony, H., Hume, J., Galster, A., Linnerud, L., Sanders, R., Hefley, G., Madden, K., Thompson, A., Shein, S., Gertz, S., Han, Y., Hughes-Schalk, A., Chandler, H., Orioles, A., Zielinski, E., Doucette, A., Zebuhr, C., Wilson, T., Dimitriades, C., Ascani, J., Layburn, S., Valley, S., Markowitz, B., Terry, J., Morzov, R., Mcinnes, A., McArthur, J., Woods, K., Murkowski, K., Spaeder, M., Sharron, M., Wheeler, D., Beckman, E., Frank, E., Howard, K., Carroll, C., Nett, S., Jarvis, D., Patel, V., Higgerson, R., Christie, L., Typpo, K., Deschenes, J., Kirby, A., Uhl, T., Rehder, K., Cheifetz, I., Wrenn, S., Kypuros, K., Ackerman, K., Maffei, F., Bloomquist, G., Rizkalla, N., Kimura, D., Shah, S., Tigges, C., Su, F., Barlow, C., Michelson, K., Wolfe, K., Goodman, D., Campbell, L., Sorce, L., Bysani, K., Monjure, T., Evans, M., Totapally, B., Chegondi, M., Rodriguez, C., Frazier, J., Steele, L., Viteri, S., Costarino, A., Spear, D., Hirshberg, E., Lilley, J., Rowan, C., Rider, C., Kane, J., Zimmerman, J., Greeley, C., Lin, J., Jacobs, R., Parker, M., Culver, K., Loftis, L., Jaimon, N., Goldsworthy, M., Bush, J., Diliberto, M., Allen, C., Gessouroun, M., Lang, T., Alkhouli, M., Kamath, S., Friel, D., Daufeldt, J., Hsing, D., Carlo, C., Pon, S., Scimeme, J., Shaheen, A., Qiao, H., Giuliano, J., Tala, J., Vinciguerra, D., Fernandez, A., Carrero, R., Hoyos, P., Jaramillo, J., Posada, A., Izquiierdo, L., Donado, J., Dalmazzo, R., Rendich, S., Palma, L., Lapadula, M., Acuna, C., Cruces, P., Clement De Clety, S., Dujardin, M., Berghe, C., Renard, S., Zurek, J., Steinherr, H., Mougkou, K., Critselis, E., Di Nardo, M., Picardo, S., Tortora, F., Rossetti, E., Fragasso, T., Cogo, P., Netto, R., Dagys, A., Gurskis, V., Kevalas, R., Neeleman, C., Lemson, J., Luijten, C., Wojciech, K., Pagowska-Klimek, I., Karpe, J., Nunes, P., Almeida, H., Rios, J., Vieira, M., Garcia Iniguez, JP, Revilla, P., Urbano, J., Lopez-Herce, J., Bustinza, A., Palacios, A., Hofheinz, S., Rodriguez-Nunez, A., Sanagustin, S., Gonzalez, E., Riaza, M., Piaya, R., Soler, P., Esteban, E., Laraudogoitia, J., Monge, C., Herrera, V., Granados, J., Gonzalez, C., Koroglu, T., Ozcelik, E., Baines, P., Plunkett, A., Davis, P., George, S., Tibby, S., Harris, J., Agbeko, R., Lampitt, R., Brierley, J., Peters, M., Jones, A., Dominguez, T., Thiruchelvam, T., Ridley, L., Bowen, W., Levin, R., Macleod, I., Gray, M., Hemat, N., Alexander, J., Ali, S., Pappachan, J., McCorkell, J., Fortune, P., MacDonald, M., Hudnott, P., Suyun, Q., Singhi, S., Nallasamy, K., Lodha, R., Shime, N., Tabata, Y., Saito, O., Ikeyama, T., Kawasaki, T., Lum, L., Abidin, A., Kee, S., Tang, S., Jalil, R., Guan, Y., Yao, L., Lin, K., Ong, J., Salloo, A., Doedens, L., Mathivha, L., Reubenson, G., Moaisi, S., Pentz, A., Green, R., Schibler, A., and Long, D.

Abstract

Objectives: The prevalence of septic acute kidney injury and impact on functional status of PICU survivors are unknown. We used data from an international prospective severe sepsis study to elucidate functional outcomes of children suffering septic acute kidney injury. Design: Secondary analysis of patients in the Sepsis PRevalence, OUtcomes, and Therapies point prevalence study: acute kidney injury was defined on the study day using Kidney Disease Improving Global Outcomes definitions. Patients with no acute kidney injury or stage 1 acute kidney injury ("no/mild acute kidney injury") were compared with those with stage 2 or 3 acute kidney injury ("severe acute kidney injury"). The primary outcome was a composite of death or new moderate disability at discharge defined as a Pediatric Overall Performance Category score of 3 or higher and increased by 1 from baseline. Setting: One hundred twenty-eight PICUs in 26 countries. Patients: Children with severe sepsis in the Sepsis PRevalence, OUtcomes, and Therapies study. Interventions: None. Measurements and Main Results: One hundred two (21%) of 493 patients had severe acute kidney injury. More than twice as many patients with severe acute kidney injury died or developed new moderate disability compared with those with no/mild acute kidney injury (64% vs 30%; p < 0.001). Severe acute kidney injury was independently associated with death or new moderate disability (adjusted odds ratio, 2.5; 95% CI, 1.5-4.2; p = 0.001) after adjustment for age, region, baseline disability, malignancy, invasive mechanical ventilation, albumin administration, and the pediatric logistic organ dysfunction score. Conclusions: In a multinational cohort of critically ill children with severe sepsis and high mortality rates, septic acute kidney injury is independently associated with further increased death or new disability.

Published
2016

21. Comparison of pediatric severe sepsis managed in U.S. and European ICUs

Author

Giuliano, John S., Markovitz, Barry P., Brierley, Joe, Levin, Richard, Williams, Gary, Lum, Lucy Chai See, Dorofaeff, Tavey, Cruces, Pablo, Bush, Jenny L., Keele, Luke, Nadkarni, V., Thomas, Neal J., Fitzgerald, Julie C., Weiss, Scott L., Fontela, P., Tucci, M., Dumistrascu, M., Skippen, P., Krahn, G., Bezares, E., Puig, G., Puig-Ramos, A., Garcia, R., Villar, M., Bigham, M., Polanski, T., Latifi, S., Giebner, D., Anthony, H., Hume, J., Galster, A., Linnerud, L., Sanders, R., Hefley, G., Madden, K., Thompson, A., Shein, S., Gertz, S., Han, Y., Williams, T., Hughes-Schalk, A., Chandler, H., Orioles, A., Zielinski, E., Doucette, A., Zebuhr, C., Wilson, T., Dimitriades, C., Ascani, J., Layburn, S., Valley, S., Terry, J., Morzov, R., McInnes, A., McArthur, J., Woods, K., Murkowski, K., Spaeder, M., Sharron, M., Wheeler, D., Beckman, E., Frank, E., Howard, K., Carroll, C., Nett, S., Jarvis, D., Patel, V., Higgerson, R., Christie, L., Typpo, K., Deschenes, J., Kirby, A., Uhl, T., Rehder, K., Cheifetz, I., Wrenn, S., Kypuros, K., Ackerman, K., Maffei, F., Bloomquist, G., Rizkalla, N., Kimura, D., Shah, S., Tigges, C., Su, F., Barlow, C., Michelson, K., Wolfe, K., Goodman, D., Campbell, L., Sorce, L., Bysani, K., Monjure, T., Evans, M., Totapally, B., Chegondi, M., Rodriguez, C., Frazier, J., Steele, L., Viteri, S., Costarino, A., Spear, D., Hirshberg, E., Lilley, J., Rowan, C., Rider, C., Kane, J., Zimmerman, J., Greeley, C., Lin, J., Jacobs, R., Parker, M., Culver, K., Loftis, L., Jaimon, N., Goldsworthy, M., Diliberto, M., Alen, C., Gessouroun, M., Sapru, A., Lang, T., Alkhouli, M., Kamath, S., Friel, D., Daufeldt, J., Hsing, D., Carlo, C., Pon, S., Scimeme, J., Shaheen, A., Hassinger, A., Qiao, H., Tala, J., Vinciguerra, D., Fernandez, A., Carrero, R., Hoyos, P., Jaramillo, J., Posada, A., Izquiierdo, L., Piñeres Olave, B. E., Donado, J., Dalmazzo, R., Rendich, S., Palma, L., Lapadula, M., Acuna, C., Clement De Clety, S., Dujardin, M., Berghe, C., Renard, S., Zurek, J., Steinherr, H., Mougkou, K., Critselis, E., Di Nardo, M., Picardo, S., Tortora, F., Rossetti, E., Fragasso, T., Cogo, P., Netto, R., Dagys, A., Gurskis, V., Kevalas, R., Neeleman, C., Lemson, J., Luijten, C., Wojciech, K., Pagowska-Klimek, I., Szczepanska, M., Karpe, J., Nunes, P., Almeida, H., Rios, J., Vieira, M., Revilla, P., Urbano, J., Lopez-Herce, J., Bustinza, A., Cuesta, A., Hofheinz, S., Rodriguez-Nunez, A., Sanagustin, S., Gonzalez, E., Riaza, M., Piaya, R., Soler, P., Esteban, E., Laraudogoitia, J., Monge, C., Herrera, V., Granados, J., Gonzalez, C., Koroglu, T., Ozcelik, E., Baines, P., Plunkett, A., Davis, P., George, S., Tibby, S., Harris, J., Agbeko, R., Lampitt, R., Peters, M., Jones, A., Dominguez, T., Thiruchelvam, T., Deep, A., Ridley, L., Bowen, W., Macleod, I., Gray, M., Hemat, N., Alexander, J., Ali, S., Pappachan, J., McCorkell, J., Fortune, P., MacDonald, M., Hudnott, P., Suyun, Q., Singhi, S., Nallasamy, K., Lodha, R., Shime, N., Tabata, Y., Saito, O., Ikeyama, T., Kawasaki, T., Abidin, A., Kee, S., Tang, S., Jalil, R., Guan, Y., Yao, L., Lin, K., Ong, J., Salloo, A., Doedens, L., Mathivha, L., Reubenson, G., Moaisi, S., Pentz, A., Green, R., Giuliano, John S., Markovitz, Barry P., Brierley, Joe, Levin, Richard, Williams, Gary, Lum, Lucy Chai See, Dorofaeff, Tavey, Cruces, Pablo, Bush, Jenny L., Keele, Luke, Nadkarni, V., Thomas, Neal J., Fitzgerald, Julie C., Weiss, Scott L., Fontela, P., Tucci, M., Dumistrascu, M., Skippen, P., Krahn, G., Bezares, E., Puig, G., Puig-Ramos, A., Garcia, R., Villar, M., Bigham, M., Polanski, T., Latifi, S., Giebner, D., Anthony, H., Hume, J., Galster, A., Linnerud, L., Sanders, R., Hefley, G., Madden, K., Thompson, A., Shein, S., Gertz, S., Han, Y., Williams, T., Hughes-Schalk, A., Chandler, H., Orioles, A., Zielinski, E., Doucette, A., Zebuhr, C., Wilson, T., Dimitriades, C., Ascani, J., Layburn, S., Valley, S., Terry, J., Morzov, R., McInnes, A., McArthur, J., Woods, K., Murkowski, K., Spaeder, M., Sharron, M., Wheeler, D., Beckman, E., Frank, E., Howard, K., Carroll, C., Nett, S., Jarvis, D., Patel, V., Higgerson, R., Christie, L., Typpo, K., Deschenes, J., Kirby, A., Uhl, T., Rehder, K., Cheifetz, I., Wrenn, S., Kypuros, K., Ackerman, K., Maffei, F., Bloomquist, G., Rizkalla, N., Kimura, D., Shah, S., Tigges, C., Su, F., Barlow, C., Michelson, K., Wolfe, K., Goodman, D., Campbell, L., Sorce, L., Bysani, K., Monjure, T., Evans, M., Totapally, B., Chegondi, M., Rodriguez, C., Frazier, J., Steele, L., Viteri, S., Costarino, A., Spear, D., Hirshberg, E., Lilley, J., Rowan, C., Rider, C., Kane, J., Zimmerman, J., Greeley, C., Lin, J., Jacobs, R., Parker, M., Culver, K., Loftis, L., Jaimon, N., Goldsworthy, M., Diliberto, M., Alen, C., Gessouroun, M., Sapru, A., Lang, T., Alkhouli, M., Kamath, S., Friel, D., Daufeldt, J., Hsing, D., Carlo, C., Pon, S., Scimeme, J., Shaheen, A., Hassinger, A., Qiao, H., Tala, J., Vinciguerra, D., Fernandez, A., Carrero, R., Hoyos, P., Jaramillo, J., Posada, A., Izquiierdo, L., Piñeres Olave, B. E., Donado, J., Dalmazzo, R., Rendich, S., Palma, L., Lapadula, M., Acuna, C., Clement De Clety, S., Dujardin, M., Berghe, C., Renard, S., Zurek, J., Steinherr, H., Mougkou, K., Critselis, E., Di Nardo, M., Picardo, S., Tortora, F., Rossetti, E., Fragasso, T., Cogo, P., Netto, R., Dagys, A., Gurskis, V., Kevalas, R., Neeleman, C., Lemson, J., Luijten, C., Wojciech, K., Pagowska-Klimek, I., Szczepanska, M., Karpe, J., Nunes, P., Almeida, H., Rios, J., Vieira, M., Revilla, P., Urbano, J., Lopez-Herce, J., Bustinza, A., Cuesta, A., Hofheinz, S., Rodriguez-Nunez, A., Sanagustin, S., Gonzalez, E., Riaza, M., Piaya, R., Soler, P., Esteban, E., Laraudogoitia, J., Monge, C., Herrera, V., Granados, J., Gonzalez, C., Koroglu, T., Ozcelik, E., Baines, P., Plunkett, A., Davis, P., George, S., Tibby, S., Harris, J., Agbeko, R., Lampitt, R., Peters, M., Jones, A., Dominguez, T., Thiruchelvam, T., Deep, A., Ridley, L., Bowen, W., Macleod, I., Gray, M., Hemat, N., Alexander, J., Ali, S., Pappachan, J., McCorkell, J., Fortune, P., MacDonald, M., Hudnott, P., Suyun, Q., Singhi, S., Nallasamy, K., Lodha, R., Shime, N., Tabata, Y., Saito, O., Ikeyama, T., Kawasaki, T., Abidin, A., Kee, S., Tang, S., Jalil, R., Guan, Y., Yao, L., Lin, K., Ong, J., Salloo, A., Doedens, L., Mathivha, L., Reubenson, G., Moaisi, S., Pentz, A., and Green, R.

Abstract

Objectives: Pediatric severe sepsis remains a significant global health problem without new therapies despite many multicenter clinical trials. We compared children managed with severe sepsis in European and U.S. PICUs to identify geographic variation, which may improve the design of future international studies. Design: We conducted a secondary analysis of the Sepsis PRevalence, OUtcomes, and Therapies study. Data about PICU characteristics, patient demographics, therapies, and outcomes were compared. Multivariable regression models were used to determine adjusted differences in morbidity and mortality. Setting: European and U.S. PICUs. Patients: Children with severe sepsis managed in European and U.S. PICUs enrolled in the Sepsis PRevalence, OUtcomes, and Therapies study. Interventions: None. Measurements and Main Results: European PICUs had fewer beds (median, 11 vs 24; p < 0.001). European patients were younger (median, 1 vs 6 yr; p < 0.001), had higher severity of illness (median Pediatric Index of Mortality-3, 5.0 vs 3.8; p = 0.02), and were more often admitted from the ward (37% vs 24%). Invasive mechanical ventilation, central venous access, and vasoactive infusions were used more frequently in European patients (85% vs 68%, p = 0.002; 91% vs 82%, p = 0.05; and 71% vs 50%; p < 0.001, respectively). Raw morbidity and mortality outcomes were worse for European compared with U.S. patients, but after adjusting for patient characteristics, there were no significant differences in mortality, multiple organ dysfunction, disability at discharge, length of stay, or ventilator/vasoactive-free days. Conclusions: Children with severe sepsis admitted to European PICUs have higher severity of illness, are more likely to be admitted from hospital wards, and receive more intensive care therapies than in the United States. The lack of significant differences in morbidity and mortality after

Published
2016

22. Group IV compounds for integrated photonic applications

Author

Gardes, F. Y., primary, Littlejohns, C. G., additional, Nedeljkovic, M., additional, Dominguez, T. Bucio, additional, Hattasan, N., additional, Banakar, M., additional, Mastronardi, L., additional, Khokhar, A. Z., additional, Grabska, K., additional, Reed, G. T., additional, Mashanovich, G. Z., additional, Runge, A. F., additional, Franz, Y., additional, Peacock, A., additional, Al-Attili, A., additional, and Saito, S., additional

Published
2016
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26. CP-107 Analisis of pharmacy interventions between 2010 and 2015

Author

Selvi-Sabater, P, primary, Gomez-Gil, A, additional, Ventura-Lopez, M, additional, Sanchez-Quiles, I, additional, Garcia-Motos, C, additional, Titos-Arcos, JC, additional, Alonso-Dominguez, T, additional, Gorostiza-Frias, I, additional, Manresa-Ramón, R, additional, and Guerrero-Bautista, R, additional

Published
2016
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29. Distance Flippled Classroom vs. TraditionalFlipped Classroom: A comparative study

Author

Domínguez Torres, Luis Carlos, Vega Peña, Neil Valentín, Sierra Barbosa, Diego Orlando, and Pepín Rubio, Juan José

Subjects
coronavirus infections, education distance, education medical undergraduate, learning, Medicine, Medicine (General), R5-920
Abstract

Introduction: In this study were compared the effects of the Conventional Flipped Classroom (virtual component for independent study + face-to-face component for the interactive discussion of clinical cases) and the Remote Flipped Classroom (FRFC) (virtual component for independent study + “online” component for the interactive discussion of clinical cases), as a teaching / learning strategy in the face of the COVID- 19 pandemic, on the self-directed learning of surgical students. Methods: Self-directed learning levels, as a result indicator of the change in methodological strategy, were compared in a group of undergraduate students participating in a conventional flipped classroom in 2017 to those of a group of students participating in a remote flipped classroom in 2020, during the surgery course at the Universidad de La Sabana, in Chía - Colombia. For this purpose, the Preparedness Scale for Self-Directed Learning (EPAD), validated to the Spanish language, was used. Results: In both groups, the levels of self-directed learning were acceptable. No significant effect (positive or negative) of either of the two models of flipped classroom was identified on the self-directed learning (d Cohen = -0.08; IC95% -0.42 – 0.24). Conclusions: The remote flipped classroom is an alternative to the conventional inverted classroom that does not compromise the self-directed learning of surgery students.

Published
2021
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30. ChemInform Abstract: Structure of 2,7,7-Trimethyl-5,6,7,8-tetrahydro-4H-furo(3,2-c)azepine- 4-thione

Author

M. SORIANO-GARCIA, E. CORTES C., E. CORTES R., J. G. AVILA Z., and A. DOMINGUEZ T.

Subjects
Crystal, chemistry.chemical_compound, chemistry, Stereochemistry, Furan, Molecule, General Medicine, Azepine, Ring (chemistry), Unit (ring theory)
Abstract

The asymmetric unit of the title compound contains two molecules with very similar geometry. The five-membered furan ring is planar and is cis-fused to the seven-membered azepine ring. The seven-membered ring adopts a twisted-sofa conformation TS1 [Boessenkool & Boeyens (1980). J. Crystallogr. Spectrosc. Res. 10, 11-18]. N-H...S bonds link adjacent molecules in the crystal

Published
2010

34. Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study

Author

Weiss, Scott L, Fitzgerald, Julie C., Maffei, Frank A., Kane, Jason M., Rodriguez Nunez, Antonio, Hsing, Deyin D., Franzon, Deborah, Kee, Sze Ying, Bush, Jenny L., Roy, Jason A., Thomas, Neal J., Nadkarni, Vinay M., Fontela, P., Tucci, M., Dumistrascu, M., Skippen, P., Krahn, G., Bezares, E., Puig, G., Puig Ramos, A., Garcia, R., Villar, M., Bigham, M., Polanski, T., Latifi, S., Giebner, D., Anthony, H., Hume, J., Galster, A., Linnerud, L., Sanders, R., Hefley, G., Madden, K., Thompson, A., Shein, S., Gertz, S., Han, Y., Williams, T., Hughes Schalk, A., Chandler, H., Orioles, A., Zielinski, E., Doucette, A., Zebuhr, C., Wilson, T., Dimitriades, C., Ascani, J., Layburn, S., Valley, S., Markowitz, B., Terry, J., Morzov, R., Mcinnes, A., Mcarthur, J., Woods, K., Murkowski, K., Spaeder, M., Sharron, M., Wheeler, D., Beckman, E., Frank, E., Howard, K., Carroll, C., Nett, S., Jarvis, D., Patel, V., Higgerson, R., Christie, L., Typpo, K., Deschenes, J., Kirby, A., Uhl, T., Rehder, K., Cheifetz, I., Wrenn, S., Kypuros, K., Ackerman, K., Maffei, F., Bloomquist, G., Rizkalla, N., Kimura, D., Shah, S., Tigges, C., Su, F., Barlow, C., Michelson, K., Wolfe, K., Goodman, D., Campbel, L., Sorce, L., Bysani, K., Monjure, T., Evans, M., Totapally, B., Chegondi, M., Rodriguez, C., Frazier, J., Steele, L., Viteri, S., Costarino, A., Thomas, N., Spear, D., Hirshberg, E., Lilley, J., Rowan, C., Rider, C., Kane, J., Zimmerman, J., Greeley, C., Lin, J., Jacobs, R., Parker, M., Culver, K., Loftis, L., Jaimon, N., Goldsworthy, M., Fitzgerald, J., Weiss, S., Nadkarni, V., Bush, J., Diliberto, M., Alen, C., Gessouroun, M., Sapru, A., Lang, T., Alkhouli, M., Kamath, S., Friel, D., Daufeldt, J., Hsing, D., Carlo, C., Pon, S., Scimeme, J., Shaheen, A., Hassinger, A., Qiao, H., Giuliano, J., Tala, J., Vinciguerra, D., Fernandez, A., Carrero, R., Hoyos, P., Jaramillo, J., Posada, A., Izquiierdo, L., Piñeres Olave, B. E., Donado, J., Dalmazzo, R., Rendich, S., Palma, L., Lapadula, M., Acuna, C., Cruces, P., Clement De Clety, S., Dujardin, M., Berghe, C., Renard, S., Zurek, J., Steinherr, H., Mougkou, K., Critselis, E., Di Nardo, M., Picardo, S., Tortora, F., Rossetti, E., Fragasso, T., Cogo, Paola, Netto, R., Dagys, A., Gurskis, V., Kevalas, R., Neeleman, C., Lemson, J., Luijten, C., Wojciech, K., Pagowska Klimek, I., Szczepanska, M., Karpe, J., Nunes, P., Almeida, H., Rios, J., Vieira, M., Revilla, P., Urbano, J., Lopez Herce, J., Bustinza, A., Cuesta, A., Hofheinz, S., Rodriguez Nunez, A., Sanagustin, S., Gonzalez, E., Riaza, M., Piaya, R., Soler, P., Esteban, E., Laraudogoitia, J., Monge, C., Herrera, V., Granados, J., Gonzalez, C., Koroglu, T., Ozcelik, E., Baines, P., Plunkett, A., Davis, P., George, S., Tibby, S., Harris, J., Agbeko, R., Lampitt, R., Bierley, J., Peters, M., Jones, A., Dominguez, T., Thiruchelvam, T., Deep, A., Ridley, L., Bowen, W., Levin, R., Macleod, I., Gray, M., Hemat, N., Alexander, J., Ali, S., Pappachan, J., Mccorkell, J., Schibler, A., Fortune, P., Macdonald, M., Hudnott, P., Erickson, S., Millar, J., Delzoppo, C., Williams, G., Morritt, M., Mceneiry, J., Long, D., Dorofaeff, T., Coulthard, M., Watts, N., Suyun, Q., Singhi, S., Nallasamy, K., Lodha, R., Shime, N., Tabata, Y., Saito, O., Ikeyama, T., Kawasaki, T., Lum, L., Abidin, A., Kee, S., Tang, S., Jalil, R., Beca, J., Sherring, C., Bushell, T., Guan, Y., Yao, L., Lin, K., Ong, J., Salloo, A., Doedens, L., Mathivha, L., Reubenson, G., Moaisi, S., Pentz, A., and Green, R.

Subjects
Male, medicine.medical_specialty, Biomedical Research, Adolescent, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Practice Patterns, macromolecular substances, Critical Care and Intensive Care Medicine, Sepsis, Intensive care, Epidemiology, Severity of illness, Clinical endpoint, Prevalence, Medicine, Humans, Practice Patterns, Physicians', Preschool, Intensive care medicine, Child, Pediatric intensive care unit, Observer Variation, Physicians', business.industry, Research, Organ dysfunction, Infant, Newborn, Infant, Child, Preschool, Female, Treatment Outcome, Newborn, medicine.disease, 3. Good health, Clinical trial, medicine.symptom, business
Abstract

Introduction Consensus criteria for pediatric severe sepsis have standardized enrollment for research studies. However, the extent to which critically ill children identified by consensus criteria reflect physician diagnosis of severe sepsis, which underlies external validity for pediatric sepsis research, is not known. We sought to determine the agreement between physician diagnosis and consensus criteria to identify pediatric patients with severe sepsis across a network of international pediatric intensive care units (PICUs). Methods We conducted a point prevalence study involving 128 PICUs in 26 countries across 6 continents. Over the course of 5 study days, 6925 PICU patients Results Of the 706 patients, 301 (42.6 %) met both definitions. The inter-rater agreement (κ ± SE) between physician diagnosis and consensus criteria was 0.57 ± 0.02. Of the 438 patients with a physician’s diagnosis of severe sepsis, only 69 % (301 of 438) would have been eligible to participate in a clinical trial of pediatric severe sepsis that enrolled patients based on consensus criteria. Patients with physician-diagnosed severe sepsis who did not meet consensus criteria were younger and had lower severity of illness and lower PICU mortality than those meeting consensus criteria or both definitions. After controlling for age, severity of illness, number of comorbid conditions, and treatment in developed versus resource-limited regions, patients identified with severe sepsis by physician diagnosis alone or by consensus criteria alone did not have PICU mortality significantly different from that of patients identified by both physician diagnosis and consensus criteria. Conclusions Physician diagnosis of pediatric severe sepsis achieved only moderate agreement with consensus criteria, with physicians diagnosing severe sepsis more broadly. Consequently, the results of a research study based on consensus criteria may have limited generalizability to nearly one-third of PICU patients diagnosed with severe sepsis.

Published
2015

36. Complete characterizations of Kadec-Klee properties in Orlicz spaces

Author

Dominguez, T., Hudzik, H., Genaro López, Mastyło, M., Sims, B., and Universidad de Sevilla. Departamento de Análisis Matemático

Subjects
Kadec-Klee property for local (global) convergence in measure, Orlicz spaces
Abstract

We study the connections between the Kadec-Klee property for local convergence in measure H`, the Kadec-Klee property for global onvergence in measure Hg and the ∆2-condition for Orlicz function spaces Lϕ equipped with either the Luxemburg norm k · kϕ or the Orlicz norm k · k0 ϕ. Nominally, we prove that for (Lϕ, k · kϕ) the conditions: ϕ satisfies an appropriate ∆2-condition and Lϕ ∈ H`, Lϕ ∈ Hg are equivalent, although Lϕ ∈ Hg is not equivalent to Eϕ ∈ Hg. In contrast, we also prove that, in the case of a non-atomic infinite measure space, properties H` and Hg for (Lϕ, k · k0 ϕ) do not coincide. More precisely, we prove that if ϕ vanishes only at zero, then both these properties coincide and they are equivalent to ϕ ∈ ∆2. However, if ϕ vanishes outside zero, then (Lϕ, k · k0 ϕ) ∈ Hg if and only if ϕ ∈ ∆2(∞). Since in the last case (Lϕ, k k0 ϕ) is not order continuous, properties H` and Hg differ. Analogous results are also proved for the subspace Eϕ of Lϕ. It is also worth mentioning that the criteria for Eϕ ∈ H` as well as for Eϕ ∈ Hg were not previously known. It follows from the criteria that the appropriate regularity ∆2-condition for ϕ is necessary for Eϕ ∈ H`, E ϕ 0 ∈ H`, Eϕ ∈ Hg and E ϕ 0 ∈ Hg although these spaces are order continuous for any ϕ.

Published
2003

37. Oxidation of carbon based materials for innovative energy systems (HTR, fusion reactor): Status and further needs

Author

Moormann, R., Hinssen, H.-K., Latge, C., Dumesnil, J., Veltkamp, A. C., Grabon, V., Beech, D., Buckthorpe, D., Dominguez, T., Krüssenberg, A.-K., and Wu, C. H.

Subjects
Oxidation of carbon based materials
Abstract

Following an overview on kinetics of carbon/gas-reactions, status and further needs in selected safety relevant fields of graphite oxidation in HTR and fusion reactors are outlined: Considering severe air ingress, lack of experimental data on Boudouard reaction and in the field of advanced oxidation kinetics was detected. Development of coatings, protecting against oxidation, has to focus on stability under neutron irradiation and on general feasability of coatings on HTR pebble fuel graphite. Oxidation in normal operation of direct-cycle HTR requires examinations on gas atmospheres and on catalytic effects. Advanced carbon materials like CFCs and mixed materials should be developed and tested with respect to their oxidation resistance in a common HTR/fusion task. In an interim HTR fuel storage radiolytic oxidation in normal operation and thermal oxidation in accidents have to be considered. Plans for future work in these fields are described.

Published
2000

48. TRACHEOSTOMIES IN 100 PEDIATRIC PATIENTS WITH CONGENITAL AND ACQUIRED HEART DISEASE

Author

Marino, B S., primary, Nathan, A, additional, Lee, A, additional, Ravishankar, C, additional, Tabbutt, S, additional, Bird, G L., additional, Tomlinson, R S., additional, Sheikh, F, additional, Ahearn, L K., additional, Godinez, R I., additional, Nicolson, S C., additional, Gaynor, J W., additional, Spray, T L., additional, Wetmore, R, additional, and Dominguez, T E., additional

Published
2005
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50. The CECRE: Supervision and control of wind and solar photovoltaic generation in Spain.

Author

de la Torre, M., Juberias, G., Dominguez, T., and Rivas, R.

Abstract

High penetration of renewable technologies, especially of wind and solar photovoltaic, has added further requirements to the control and supervision of power systems. In particular, their dispersion and their non-manageable variability involve the need to increase the attention and readiness to act of power system operators. In order to cope with these challenges in an efficient manner, control centers must be equipped with tools that automate processes in order to aid operators. One example of such a control center is the Spanish TSO's CECRE, equipped with tools and communication capabilities to supervise all the commercial wind and 60% of the solar photovoltaic generation installed in the Spanish peninsular system. In this system wind energy accounted for 16% and solar for 2.5% of the total electrical energy produced in the year 2010 and is one of the systems in the world with the highest non-manageable renewable energy penetration levels. In addition, the CECRE checks whether the real time generation scenario of these technologies is admissible and issues limitations as set-points to each single plant when the technical constraints detected can only be solved by means of reducing the non-manageable renewable generation. This paper describes the tools involved in this process and how the three presently possible types of constraints to integration are managed: congestions either in the transmission or distribution system, generation trips due to voltage dips and off-peak power balance feasibility. [ABSTRACT FROM PUBLISHER]

Published
2012
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