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1. Aberrant DNA methylation impacts HOX genes expression in bone marrow mesenchymal stromal cells of myelodysplastic syndromes and de novo acute myeloid leukemia

Author

Roux, Benjamin, Picou, Frédéric, Debeissat, Christelle, Koubi, Myriam, Gallay, Nathalie, Hirsch, Pierre, Ravalet, Noémie, Béné, Marie C., Maigre, Michel, Hunault, Mathilde, Mosser, Jean, Etcheverry, Amandine, Gyan, Emmanuel, Delhommeau, François, Domenech, Jorge, and Herault, Olivier

Published
2022
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3. Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells

Author

Kouzi, Farah, Zibara, Kazem, Bourgeais, Jerome, Picou, Frederic, Gallay, Nathalie, Brossaud, Julie, Dakik, Hassan, Roux, Benjamin, Hamard, Sophie, Le Nail, Louis-Romee, Hleihel, Rita, Foucault, Amelie, Ravalet, Noemie, Rouleux-Bonnin, Florence, Gouilleux, Fabrice, Mazurier, Frederic, Bene, Marie C., Akl, Haidar, Gyan, Emmanuel, Domenech, Jorge, El-Sabban, Marwan, and Herault, Olivier

Published
2020
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4. Characteristics, combinations, treatments, and survival of second primary hematological neoplasm: a retrospective single-center cohort of 49 patients (Hemo2study)

Author

Chalopin, Thomas, Vallet, Nicolas, Arbion, Flavie, Barin, Carole, Rault, Emmanuelle, Villate, Alban, Eloit, Martin, La Rochelle, Laurianne Drieu, Foucault, Amélie, Ertault, Marjan, Dartigeas, Caroline, Benboubker, Lotfi, Estienne, Marie-Hélène, Domenech, Jorge, Hérault, Olivier, and Gyan, Emmanuel

Published
2019
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5. SmartLife – Exergames and Smart Textiles to Promote Energy-Related Behaviours Among Adolescents

Author

Doménech, Jorge, Ferri, Josué, Costa, Ruben, Oliveira, Pedro, Grilo, Antonio, Cardon, Greet, DeSmet, Ann, Schwarz, Ayla, Stragier, Jeroen, Pomazanskyi, Andrew, Danilins, Jevgenijs, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Göbel, Stefan, editor, Garcia-Agundez, Augusto, editor, Tregel, Thomas, editor, Ma, Minhua, editor, Baalsrud Hauge, Jannicke, editor, Oliveira, Manuel, editor, Marsh, Tim, editor, and Caserman, Polona, editor

Published
2018
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6. Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs)

Author

Aggoune, Djamel, Sorel, Nathalie, Bonnet, Marie-Laure, Goujon, Jean-Michel, Tarte, Karin, Hérault, Olivier, Domenech, Jorge, Réa, Delphine, Legros, Laurence, Johnson-Ansa, Hyacinthe, Rousselot, Philippe, Cayssials, Emilie, Guerci-Bresler, Agnès, Bennaceur-Griscelli, Annelise, Chomel, Jean-Claude, and Turhan, Ali G.

Published
2017
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7. Correction: Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells

Author

Kouzi, Farah, Zibara, Kazem, Bourgeais, Jerome, Picou, Frederic, Gallay, Nathalie, Brossaud, Julie, Dakik, Hassan, Roux, Benjamin, Hamard, Sophie, Le Nail, Louis-Romee, Hleihel, Rita, Foucault, Amelie, Ravalet, Noemie, Rouleux-Bonnin, Florence, Gouilleux, Fabrice, Mazurier, Frederic, Bene, Marie C., Akl, Haidar, Gyan, Emmanuel, Domenech, Jorge, El-Sabban, Marwan, and Herault, Olivier

Published
2020
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9. Low-Dose Pesticides Alter Primary Human Bone Marrow Mesenchymal Stem/Stromal Cells through ALDH2 Inhibition

Author

Foucault, Amélie, primary, Ravalet, Noémie, additional, Besombes, Joevin, additional, Picou, Frédéric, additional, Gallay, Nathalie, additional, Babin, Laetitia, additional, Bourgeais, Jérôme, additional, Hamard, Sophie, additional, Domenech, Jorge, additional, Loyer, Pascal, additional, Vallet, Nicolas, additional, Lejeune, Julien, additional, Gyan, Emmanuel, additional, Béné, Marie C., additional, Vallette, François, additional, Olivier, Christophe, additional, and Hérault, Olivier, additional

Published
2021
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14. Comentarios a las Sentencias de Unificación de Doctrina. Civil y Mercantil : Volumen 10, 2018

Author

Tolsada, Mariano Yzquierdo, Director Catedrático de Derecho civil, Royo-Villanova, Segismundo Álvarez, Abad, Bernardo Arroyo, Trejo, Ricardo Cabanas, Caravaca, Alfonso-luis Calvo, González, Javier Carrascosa, Gómez, José Antonio Cobacho, de Amunátegui Rodríguez, Cristina, de Paula Blasco Gascó, Francisco, Luelmo, Andrés Domínguez, Miguel, Ignacio Farrando, Domínguez, Ignacio Gallego, Inchausti, Fernando Gascón, Lanzón, Ignacio Gomá, Lanzón, Fernando Gomá, Hernández, Rut González, Martín-Calero, Cristina Guilarte, Santiago, Pilar Gutiérrez, Pombo, Eugenio Llamas, Grande, Javier Mendieta, garcía, Carmen muñoz, Doménech, Jorge Ortega, García-Castrillón, Carmen Otero, hereza, Juan perez, Trigo, Francisco Redondo, Arregui, Rodrigo Tena, García, Enrique Vallines, Tolsada, Mariano Yzquierdo, Quintanilla, Sara Zubero, Tolsada, Mariano Yzquierdo, Royo-Villanova, Segismundo Álvarez, Abad, Bernardo Arroyo, Trejo, Ricardo Cabanas, Caravaca, Alfonso-luis Calvo, González, Javier Carrascosa, Gómez, José Antonio Cobacho, de Amunátegui Rodríguez, Cristina, de Paula Blasco Gascó, Francisco, Luelmo, Andrés Domínguez, Miguel, Ignacio Farrando, Domínguez, Ignacio Gallego, Inchausti, Fernando Gascón, Lanzón, Ignacio Gomá, Lanzón, Fernando Gomá, Hernández, Rut González, Martín-Calero, Cristina Guilarte, Santiago, Pilar Gutiérrez, Pombo, Eugenio Llamas, Grande, Javier Mendieta, garcía, Carmen muñoz, Doménech, Jorge Ortega, García-Castrillón, Carmen Otero, hereza, Juan perez, Trigo, Francisco Redondo, Arregui, Rodrigo Tena, García, Enrique Vallines, Tolsada, Mariano Yzquierdo, and Quintanilla, Sara Zubero

Published
2019
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15. A comparative study of the capacity of mesenchymal stromal cell lines to form spheroids

Author

Deynoux, Margaux, Sunter, Nicola, Ducrocq, Elfi, Dakik, Hassan, Guibon, Roseline, Burlaud-Gaillard, Julien, Brisson, Lucie, Rouleux-Bonnin, Florence, le Nail, Louis-Romée, Hérault, Olivier, Domenech, Jorge, Roingeard, Philippe, Fromont, Gaëlle, Mazurier, Frédéric, ERL 7001 LNOx (Leukemic Niche & redOx metabolism / Niche leucémique et métabolisme redOx) (LNOx), Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours (UT)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Anatomie et cytologie pathologique [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Nutrition, croissance et cancer (U 1069) (N2C), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme IBISA de Microscopie Electronique [CHRU de Tours] (UNIV Tours), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Université de Tours (UT), Morphogénèse et antigénicité du VIH et du virus des Hépatites (MAVIVH - U1259 Inserm - CHRU Tours ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Chirurgie orthopédique [Tours], Service d'Hématologie biologique [Tours], The authors acknowledge the Ministry of Research (MD), the ARC Foundation (MD, HD), the French Society of Hematology (MD), the 'Ligue contre le Cancer (NS)', and the Lebanese south governate (HD) for their funding. This work was supported by the French Committees of the 'Ligue Contre le Cancer Grand-Ouest' [16 (Charente), 36 (Indre), 37 (Indre-et-Loire), 41 (Loire et Cher), and 86 (Vendée)] and the Région Centre Val de Loire (FM)., Bodescot, Myriam, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Centre National de la Recherche Scientifique (CNRS)-Microenvironnement des niches tumorales (CNRS GDR 3697 Micronit ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours (UT)-Université de Tours (UT), Université de Tours-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS)-Université de Tours, and Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS)

Subjects
Autophagic Cell Death, Cell Lines, Science, Apoptosis, [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Research and Analysis Methods, Cell Line, Mice, Animal Cells, Spheroids, Cellular, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Animals, Humans, Electron Microscopy, Hypoxia, Cell Aggregation, Cell Proliferation, Staining, Microscopy, Cell Death, Stem Cells, Biology and Life Sciences, Cell Staining, Mesenchymal Stem Cells, Cell Biology, Cell Dedifferentiation, Cell Hypoxia, Oxidative Stress, Cell Processes, Specimen Preparation and Treatment, embryonic structures, Medicine, Biological Cultures, Scanning Electron Microscopy, Cellular Types, Stem Cell Lines, Research Article
Abstract

International audience; Mesenchymal stem cells (MSC)-spheroid models favor maintenance of stemness, ex vivo expansion and transplantation efficacy. Spheroids may also be considered as useful surrogate models of the hematopoietic niche. However, accessibility to primary cells, from bone marrow (BM) or adipose tissues, may limit their experimental use and the lack of consistency in methods to form spheroids may affect data interpretation. In this study, we aimed to create a simple model by examining the ability of cell lines, from human (HS-27a and HS-5) and murine (MS-5) BM origins, to form spheroids, compared to primary human MSCs (hMSCs). Our protocol efficiently allowed the spheroid formation from all cell types within 24 hours. Whilst hMSC-spheroids began to shrink after 24 hours, the size of spheroids from cell lines remained constant during three weeks. The difference was partially explained by the balance between proliferation and cell death, which could be triggered by hypoxia and induced oxidative stress. Our results demonstrate that, like hMSCs, MSC cell lines make reproductible spheroids that are easily handled. Thus, this model could help in understanding mechanisms involved in MSC functions and may provide a simple model by which to study cell interactions in the BM niche.

Published
2020

16. Involvement of GPx-3 in the Reciprocal Control of Redox Metabolism in the Leukemic Niche

Author

Vignon, Christine, primary, Debeissat, Christelle, additional, Bourgeais, Jérôme, additional, Gallay, Nathalie, additional, Kouzi, Farah, additional, Anginot, Adrienne, additional, Picou, Frédéric, additional, Guardiola, Philippe, additional, Ducrocq, Elfi, additional, Foucault, Amélie, additional, Ravalet, Noémie, additional, Le Nail, Louis-Romée, additional, Domenech, Jorge, additional, Béné, Marie-Christine, additional, Le Bousse-Kerdilès, Marie-Caroline, additional, Gyan, Emmanuel, additional, and Herault, Olivier, additional

Published
2020
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17. Aberrant DNA methylation impacts HOXgenes expression in bone marrow mesenchymal stromal cells of myelodysplastic syndromes and de novo acute myeloid leukemia

Author

Roux, Benjamin, Picou, Frédéric, Debeissat, Christelle, Koubi, Myriam, Gallay, Nathalie, Hirsch, Pierre, Ravalet, Noémie, Béné, Marie C., Maigre, Michel, Hunault, Mathilde, Mosser, Jean, Etcheverry, Amandine, Gyan, Emmanuel, Delhommeau, François, Domenech, Jorge, and Herault, Olivier

Abstract

DNA methylation, a major biological process regulating the transcription, contributes to the pathophysiology of hematologic malignancies, and hypomethylating agents are commonly used to treat myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML). In these diseases, bone marrow mesenchymal stromal cells (MSCs) play a key supportive role through the production of various signals and interactions. The DNA methylation status of MSCs, likely to reflect their functionality, might be relevant to understand their contribution to the pathophysiology of these diseases. Consequently, the aim of our study was to analyze the modifications of DNA methylation profiles of MSCs induced by MDS or AML. MSCs from MDS/AML patients were characterized via5-methylcytosine quantification, gene expression profiles of key regulators of DNA methylation, identification of differentially methylated regions (DMRs) by methylome array, and quantification of DMR-coupled genes expression. MDS and AML-MSCs displayed global hypomethylation and under-expression of DNMT1and UHRF1. Methylome analysis revealed aberrant methylation profiles in all MDS and in a subgroup of AML-MSCs. This aberrant methylation was preferentially found in the sequence of homeobox genes, especially from the HOXfamily (HOXA1, HOXA4, HOXA5, HOXA9, HOXA10, HOXA11, HOXB5, HOXC4, and HOXC6), and impacted on their expression. These results highlight modifications of DNA methylation in MDS/AML-MSCs, both at global and focal levels dysregulating the expression of HOXgenes well known for their involvement in leukemogenesis. Such DNA methylation in MSCs could be the consequence of the malignant disease or could participate in its development through defective functionality or exosomal transfer of HOX transcription factors from MSCs to hematopoietic cells.

Published
2022
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18. Correction: Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells

Author

Kouzi, Farah, primary, Zibara, Kazem, additional, Bourgeais, Jerome, additional, Picou, Frederic, additional, Gallay, Nathalie, additional, Brossaud, Julie, additional, Dakik, Hassan, additional, Roux, Benjamin, additional, Hamard, Sophie, additional, Le Nail, Louis-Romee, additional, Hleihel, Rita, additional, Foucault, Amelie, additional, Ravalet, Noemie, additional, Rouleux-Bonnin, Florence, additional, Gouilleux, Fabrice, additional, Mazurier, Frederic, additional, Bene, Marie C., additional, Akl, Haidar, additional, Gyan, Emmanuel, additional, Domenech, Jorge, additional, El-Sabban, Marwan, additional, and Herault, Olivier, additional

Published
2019
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19. A comparative study of the capacity of mesenchymal stromal cell lines to form spheroids

Author

Deynoux, Margaux, primary, Sunter, Nicola, additional, Ducrocq, Elfi, additional, Dakik, Hassan, additional, Guibon, Roseline, additional, Burlaud-Gaillard, Julien, additional, Brisson, Lucie, additional, le Nail, Louis-Romée, additional, Hérault, Olivier, additional, Domenech, Jorge, additional, Roingeard, Philippe, additional, Fromont, Gaëlle, additional, and Mazurier, Frédéric, additional

Published
2019
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20. Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells

Author

Kouzi, Farah, primary, Zibara, Kazem, additional, Bourgeais, Jerome, additional, Picou, Frederic, additional, Gallay, Nathalie, additional, Brossaud, Julie, additional, Dakik, Hassan, additional, Roux, Benjamin, additional, Hamard, Sophie, additional, Le Nail, Louis-Romee, additional, Hleihel, Rita, additional, Foucault, Amelie, additional, Ravalet, Noemie, additional, Rouleux-Bonnin, Florence, additional, Gouilleux, Fabrice, additional, Mazurier, Frederic, additional, Bene, Marie C., additional, Akl, Haidar, additional, Gyan, Emmanuel, additional, Domenech, Jorge, additional, El-Sabban, Marwan, additional, and Herault, Olivier, additional

Published
2019
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31. n-3 Polyunsaturated fatty acids induce acute myeloid leukemia cell death associated with mitochondrial glycolytic switch and Nrf2 pathway activation

Author

Picou, Frédéric, primary, Debeissat, Christelle, additional, Bourgeais, Jérôme, additional, Gallay, Nathalie, additional, Ferrié, Elise, additional, Foucault, Amélie, additional, Ravalet, Noémie, additional, Maciejewski, Aurore, additional, Vallet, Nicolas, additional, Ducrocq, Elfi, additional, Haddaoui, Lamya, additional, Domenech, Jorge, additional, Hérault, Olivier, additional, and Gyan, Emmanuel, additional

Published
2018
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33. Influence of hypoxia on the domiciliation of Mesenchymal Stem Cells after infusion into rats: possibilities of targeting pulmonary artery remodeling via cells therapies?

Author

Domenech Jorge, Pages Jean-Christophe, Bonnet Nicolas, Vaudin Pascal, Rochefort Gaël Y, Charbord Pierre, and Eder Véronique

Subjects
arteries, hypertension, pulmonary, hypoxia, lung, remodeling, mesenchymal stem cells., Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Bone marrow (BM) cells are promising tools for vascular therapies. Here, we focused on the possibility of targeting the hypoxia-induced pulmonary artery hypertension remodeling with systemic delivery of BM-derived mesenchymal stem cells (MSCs) into non-irradiated rats. Methods Six-week-old Wistar rats were exposed to 3-week chronic hypoxia leading to pulmonary artery wall remodeling. Domiciliation of adhesive BM-derived CD45- CD73+ CD90+ MSCs was first studied after a single intravenous infusion of Indium-111-labeled MSCs followed by whole body scintigraphies and autoradiographies of different harvested organs. In a second set of experiments, enhanced-GFP labeling allowed to observe distribution at later times using sequential infusions during the 3-week hypoxia exposure. Results A 30% pulmonary retention was observed by scintigraphies and no differences were observed in the global repartition between hypoxic and control groups. Intrapulmonary radioactivity repartition was homogenous in both groups, as shown by autoradiographies. BM-derived GFP-labeled MSCs were observed with a global repartition in liver, in spleen, in lung parenchyma and rarely in the adventitial layer of remodeled vessels. Furthermore this global repartition was not modified by hypoxia. Interestingly, these cells displayed in vivo bone marrow homing, proving a preservation of their viability and function. Bone marrow homing of GFP-labeled MSCs was increased in the hypoxic group. Conclusion Adhesive BM-derived CD45- CD73+ CD90+ MSCs are not integrated in the pulmonary arteries remodeled media after repeated intravenous infusions in contrast to previously described in systemic vascular remodeling or with endothelial progenitor cells infusions.

Published
2005
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34. Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses

Author

Bourgeais, Jerome, Ishac, Nicole, Medrzycki, Magdalena, Brachet-Botineau, Marie, Desbourdes, Laura, Gouilleux-Gruart, Valérie, Pecnard, Emmanuel, Rouleux-Bonnin, Florence, Gyan, Emmanuel, Domenech, Jorge, Mazurier, Frédéric, Moriggl, Richard, Bunting, Kevin, Herault, Olivier, Gouilleux, Fabrice, Génétique, immunothérapie, chimie et cancer (GICC), UMR 7292 CNRS [2012-2017] (GICC UMR 7292 CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Développement normal et pathologique des lymphocytes et signalisation, Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hématologie, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Medizinische Universität Wien = Medical University of Vienna, Gouilleux, Fabrice, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Université de Tours-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, Fusion Proteins, bcr-abl, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Cell Cycle Checkpoints, Catalase, Models, Biological, Antioxidants, Oxidative Stress, [SDV.CAN] Life Sciences [q-bio]/Cancer, chronic myeloid leukemia, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], STAT5 Transcription Factor, Humans, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Reactive Oxygen Species, STAT5, Glutaredoxins, Research Paper, Bcr-Abl, Signal Transduction
Abstract

International audience; STAT5 transcription factors are frequently activated in hematopoietic neoplasms and are targets of various tyrosine kinase oncogenes. Evidences for a crosstalk between STAT5 and reactive oxygen species (ROS) metabolism have recently emerged but mechanisms involved in STAT5-mediated regulation of ROS still remain elusive. We demonstrate that sustained activation of STAT5 induced by Bcr-Abl in chronic myeloid leukemia (CML) cells promotes ROS production by repressing expression of two antioxidant enzymes, catalase and glutaredoxin-1(Glrx1). Downregulation of catalase and Glrx1 expression was also observed in primary cells from CML patients. Catalase was shown not only to reduce ROS levels but also, to induce quiescence in Bcr-Abl-positive leukemia cells. Furthermore, reduction of STAT5 phosphorylation and upregulation of catalase and Glrx1 were also evidenced in leukemia cells co-cultured with bone marrow stromal cells to mimic a leukemic niche. This caused downregulation of ROS levels and enhancement of leukemic cell quiescence. These data support a role of persistent STAT5 signaling in the regulation of ROS production in myeloid leukemias and highlight the repression of antioxidant defenses as an important regulatory mechanism.

Published
2017

35. Characteristics, combinations, treatments, and survival of second primary hematological neoplasm: a retrospective single-center cohort of 49 patients (Hemo2study).

Author

Chalopin, Thomas, Vallet, Nicolas, Arbion, Flavie, Barin, Carole, Rault, Emmanuelle, Villate, Alban, Eloit, Martin, La Rochelle, Laurianne Drieu, Foucault, Amélie, Ertault, Marjan, Dartigeas, Caroline, Benboubker, Lotfi, Estienne, Marie-Hélène, Domenech, Jorge, Hérault, Olivier, and Gyan, Emmanuel

Subjects
SECONDARY primary cancer, HEMATOLOGIC malignancies, HODGKIN'S disease, MULTIPLE myeloma, PROGRESSION-free survival
Abstract

The coexistence of dual hematological neoplasms is very rare. Sequential or synchronous neoplasms in hematology are an uncommon and complex clinical situation. The aim of the Hemo2 study was to describe the clinical characteristics and analyze the outcome of these patients. We performed a retrospective review of all patients diagnosed with sequential or synchronous hematological malignancies in the university hospital of Tours, between 2007 and 2018. We identified 49 patients in our study, with a prevalence of 0.89%. Sequential and synchronous combinations were found in 36 (73%) and 13 (27%) patients, respectively. One patient presented three sequential neoplasms. The median cumulative incidence was 6 years (95% CI 3-7). Among all neoplasms diagnosed (n = 99), we found 79 lymphoid neoplasms (LNs) (80%) and 20 myeloid neoplasms (MNs) (20%). Sex ratio was 1.88 with 65% of males and 35% of females. The most common LNs were Hodgkin lymphoma (n = 16; 16%) and multiple myeloma (n = 11; 11%). The most frequent MN was essential thrombocythemia (n = 5; 5%). The most common combination was Hodgkin lymphoma and follicular lymphoma in five (10%) patients. The overall survival from the first diagnosis (OS1) at 5 years was 82.4% (95% CI 72.1-94.3). The median overall survival from the second diagnosis (OS2) was 98 months (95% CI 44-NR) and 5-year OS2 was 58.7% (95% CI 45.5-75.7). Median progression-free survival from the second diagnosis (PFS) was 47 months (95% CI 27-NR) with 5-year PFS of 49% (95% CI 35.9-67). OS and PFS did not statistically differ between synchronous and sequential dual neoplasms. In this cohort, that the death relative risk (RR) was significantly lower if the second neoplasm appeared after more than 4 years following the first diagnosis (OR 0.37 (95% CI 0.16-0.90)). The Hemo2study confirmed the rarity of dual hematological neoplasms. In this cohort, HL and FL were the most frequent combinations. Our results may support that synchronous and sequential dual neoplasms bear the same prognosis. Further studies are needed to better characterize these uncommon clinical situations. [ABSTRACT FROM AUTHOR]

Published
2019
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36. Merkel cell carcinomas infiltrated with CD33 + myeloid cells and CD8 + T cells are associated with improved outcome

Author

Kervarrec, Thibault, primary, Gaboriaud, Pauline, additional, Berthon, Patricia, additional, Zaragoza, Julia, additional, Schrama, David, additional, Houben, Roland, additional, Le Corre, Yannick, additional, Hainaut-Wierzbicka, Ewa, additional, Aubin, Francois, additional, Bens, Guido, additional, Domenech, Jorge, additional, Guyétant, Serge, additional, Touzé, Antoine, additional, and Samimi, Mahtab, additional

Published
2018
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40. Alteration Analysis of Bone Marrow Mesenchymal Stromal Cells from De Novo Acute Myeloid Leukemia Patients at Diagnosis

Author

Desbourdes, Laura, primary, Javary, Joaquim, additional, Charbonnier, Thomas, additional, Ishac, Nicole, additional, Bourgeais, Jerome, additional, Iltis, Aurore, additional, Chomel, Jean-Claude, additional, Turhan, Ali, additional, Guilloton, Fabien, additional, Tarte, Karin, additional, Demattei, Marie-Veronique, additional, Ducrocq, Elfi, additional, Rouleux-Bonnin, Florence, additional, Gyan, Emmanuel, additional, Hérault, Olivier, additional, and Domenech, Jorge, additional

Published
2017
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41. Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses

Author

Bourgeais, Jerome, primary, Ishac, Nicole, additional, Medrzycki, Magdalena, additional, Brachet-Botineau, Marie, additional, Desbourdes, Laura, additional, Gouilleux-Gruart, Valerie, additional, Pecnard, Emmanuel, additional, Rouleux-Bonnin, Florence, additional, Gyan, Emmanuel, additional, Domenech, Jorge, additional, Mazurier, Frederic, additional, Moriggl, Richard, additional, Bunting, Kevin D., additional, Herault, Olivier, additional, and Gouilleux, Fabrice, additional

Published
2016
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43. Characterization of chicken adherent spleen cells and functional interaction with Toxoplasma gondii protozoan

Author

Quéré, Pascale, Pierre, Josette, Hoang, My Dung, Esnault, Evelyne, Domenech, Jorge, Sibille, Pierre, Dimier-Poisson, Isabelle, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Université Francois Rabelais [Tours], Génétique, immunothérapie, chimie et cancer (GICC), UMR 7292 CNRS [2012-2017] (GICC UMR 7292 CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), BBSRC Roslin Institute. Edinburgh, GBR., Institut National de la Recherche Agronomique (INRA)-Université de Tours, Université de Tours-Centre National de la Recherche Scientifique (CNRS), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

44. Integración de pilas de combustible en hospitales

Author

Mas Domenech, Jorge, Llorca Piqué, Jordi, Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, and Llorca i Piqué, Jordi

Subjects
Hospitals -- Energy consumption, Hospitals -- Consum d'energia, Energies::Energia elèctrica::Electricitat [Àrees temàtiques de la UPC], Enginyeria química::Química física::Electroquímica [Àrees temàtiques de la UPC], Piles de combustible, Fuel cells
Abstract

En este proyecto se realiza un estudio sobre la integración de pilas de combustible en hospitales, concretamente en una clínica de la cual se han podido obtener datos fiables del sistema de generación de electricidad existente, así como los consumos de energía (térmica y eléctrica). El objetivo del presente proyecto consiste en sustituir el grupo electrógeno actual por una pila de combustible y comparar esta solución con la existente. En primer lugar se lleva a cabo un estudio del sistema actual: características del grupo electrógeno, identificación de las cargas críticas (suministro crítico), etc. Una vez se conoce el sistema actual, se escoge un modelo de pila de combustible adecuado: en el presente caso se trata de una pila de combustible para aplicaciones estacionarias que es capaz de suministrar la potencia eléctrica que genera el actual grupo electrógeno. La pila escogida (en realidad todo el sistema) se alimenta directamente de gas natural, y mediante un proceso de reformado dentro del mismo sistema, se obtiene el hidrógeno que alimenta la pila de combustible propiamente dicha. La pila de combustible actúa como un sistema de cogeneración, ya que además de producir electricidad se produce calor útil. La principal diferencia del sistema actual con el sistema que se propone, radica no únicamente en el hecho de cambiar un grupo electrógeno por una pila de combustible, sino en el hecho de que con la pila de combustible, además de utilizarla en caso de fallo en el suministro eléctrico (función del grupo electrógeno actual), se puede satisfacer gran parte de la demanda energética eléctrica y térmica de una manera menos contaminante y más económica que obteniéndola de la red eléctrica o de la caldera. Esta configuración de utilizar conjuntamente la pila de combustible con la red eléctrica, pasa por encontrar para cada mes del año el grado de utilización óptimo de la pila. Finalmente se comprueba que la realización del presente proyecto está justificada desde un punto de vista medio ambiental, y atendiéndose a motivos económicos, hay que tener en cuenta que la inversión se recupera al cabo de bastante tiempo y que la rentabilidad no es especialmente elevada.

Published
2009

48. Molecular Characterization of the Leukemic Niche in Chronic Myeloid Leukemia (CML) and Evaluation of a Leukemia / Niche Cross-Talk

Author

Aggoune, Djamel, primary, Sorel, Nathalie, additional, Marsafy, Sanaa El, additional, Bonnet, Marie Laure, additional, Clay, Denis, additional, Meunier, Marie Claude, additional, Tarte, Karin, additional, Herault, Olivier, additional, Domenech, Jorge, additional, Guerci, Agnès, additional, Chomel, Jean-Claude, additional, and Turhan, Ali G, additional

Published
2012
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