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22. Change of Circulating Vascular Endothelial Growth Factor Level and Reduction of Anhedonia Are Associated in Patients With Major Depressive Disorder Treated With Repetitive Transcranial Magnetic Stimulation

Author

Elemery, Monika, Kiss, Szilvia, Dome, Peter, Pogany, Laszlo, Faludi, Gabor, and Lazary, Judit

Subjects
Psychiatry and Mental health
Abstract

AimVascular endothelial growth factor (VEGF) has been implicated in mediating the effect of antidepressant therapies as it plays a significant role in the neurogenesis. Anhedonia, an endophenotype of major depressive disorder (MDD), is related to the dorsolateral prefrontal cortex, the major focus of brain stimulation in MDD. The aim of our study was to analyze the change of serum VEGF level after rTMS treatment in association with anhedonia.Materials and MethodsA dataset of 17 patients with TRD who were treated with antidepressants and bilateral rTMS for 2 × 5 days was analyzed. Depression was measured by the Montgomery–Asberg Depression Scale (MADRS) and anhedonia by the Snaith–Hamilton Pleasure Scale (SHAPS) for monitoring the symptom changes. The serum VEGF levels and symptoms were assessed on the first (V1), on the 14th (V2), and on the 28th day (V3). The level of VEGF was measured by ELISA assay.ResultsThere was no significant association between MADRS scores and serum VEGF levels at any timepoint. The decrease in the SHAPS score was significantly associated with the increase in VEGF level between V1 and V2 (p = 0.001). The VEGF levels were significantly higher in non-responders than in responders (p = 0.04). The baseline VEGF level has been proven as a significant predictor of treatment response (p = 0.045).ConclusionOur results suggest that serum VEGF can be sensitive to the changes of anhedonia during rTMS treatment. Considering that the most widely used depression scales are not applicable for the assessment of anhedonia, measurement of anhedonia in rTMS treatment studies of patients with TRD can be suggested as more appropriate data on distinct pathogenic pathways and specific biomarkers of the disorder.

Published
2022
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32. JSE sees fresh opportunities despite pandemic setbacks: Running a stock exchange under lockdown has not been easy, but JSE CEO Leila Fourie sees these as exhilarating times with new opportunities emerging

Author

Dome, Peter

Subjects
Chief executive officers -- Interviews, Securities industry -- Officials and employees -- Economic aspects, Stock exchanges -- Economic aspects, Epidemics -- Economic aspects -- South Africa, COVID-19 -- Economic aspects, Securities industry, Business, Business, international
Abstract

When Leila Fourie was appointed Group CEO of the Johannesburg Stock Exchange (JSE) in October 2019, 'in many ways, it was like going back home,' she says. Fourie held executive [...]

Published
2020

33. Relationship of suicide rates to economic variables in Europe: 2000–2011

Author

Fountoulakis, Konstantinos N., Kawohl, Wolfram, Theodorakis, Pavlos N., Kerkhof, Ad J. F. M., Navickas, Alvydas, Höschl, Cyril, Lecic-Tosevski, Dusica, Sorel, Eliot, Rancans, Elmars, Palova, Eva, Juckel, Georg, Isacsson, Goran, Jagodic, Helena Korosec, Botezat-Antonescu, Ileana, Warnke, Ingeborg, Rybakowski, Janusz, Azorin, Jean Michel, Cookson, John, Waddington, John, Pregelj, Peter, Demyttenaere, Koen, Hranov, Luchezar G., Stevovic, Lidija Injac, Pezawas, Lucas, Adida, Marc, Figuera, Maria Luisa, Pompili, Maurizio, Jakovljević, Miro, Vichi, Monica, Perugi, Giulio, Andrasen, Ole, Vukovic, Olivera, Mavrogiorgou, Paraskevi, Varnik, Peeter, Bech, Per, Dome, Peter, Winkler, Petr, Salokangas, Raimo K. R., From, Tiina, Danileviciute, Vita, Gonda, Xenia, Rihmer, Zoltan, Benhalima, Jonas Forsman, Grady, Anne, Leadholm, Anne Katrine Kloster, Soendergaard, Susan, Nordt, Carlos, and Lopez-Ibor, Juan

Published
2014

34. Novel antidepressant drugs: Beyond monoamine targets

Author

Gonda, Xenia, Dome, Peter, Neill, Joanna C., and Tarazi, Frank I.

Abstract

AbstractTreatment of major depressive disorder (MDD) including treatment-resistant depression (TRD) remains a major unmet need. Although there are several classes of dissimilar antidepressant drugs approved for MDD, the current drugs have either limited efficacy or are associated with undesirable side effects and withdrawal symptoms. The efficacy and side effects of antidepressant drugs are mainly attributed to their actions on different monoamine neurotransmitters (serotonin, norepinephrine, and dopamine). Development of new antidepressants with novel targets beyond the monoamine pathways may fill the unmet need in treatment of MDD and TRD. The recent approval of intranasal Esketamine (glutamatergic agent) in conjunction with an oral antidepressant for the treatment of adult TRD patients was the first step toward expanding beyond the monoamine targets. Several other glutamatergic (AXS-05, REL-1017, AV-101, SLS-002, AGN24175, and PCN-101) and GABAergic (brexanolone, zuranolone, and ganaxolone) drugs are currently in different stages of clinical development for MDD, TRD and other indications. The renaissance of psychedelic drugs and the emergence of preliminary positive clinical trial results with psilocybin, Ayahuasca, 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), and lysergic acid diethylamide (LSD) may pave the way towards establishing this class of drugs as effective therapies for MDD, TRD and other neuropsychiatric disorders. Going beyond the monoamine targets appears to be an effective strategy to develop novel antidepressant drugs with superior efficacy, safety, and tolerability for the improved treatment of MDD and TRD.

Published
2023
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46. MOESM1 of Relationship of suicide rates with climate and economic variables in Europe during 2000â 2012

Author

Fountoulakis, Konstantinos, Chatzikosta, Isaia, Pastiadis, Konstantinos, Prodromos Zanis, Kawohl, Wolfram, Kerkhof, Ad, Navickas, Alvydas, Höschl, Cyril, Dusica Lecic-Tosevski, Sorel, Eliot, Elmars Rancans, Palova, Eva, Juckel, Georg, Isacsson, Goran, Jagodic, Helena, Botezat-Antonescu, Ileana, Rybakowski, Janusz, Azorin, Jean, Cookson, John, Waddington, John, Pregelj, Peter, Demyttenaere, Koen, Hranov, Luchezar, Stevovic, Lidija, Pezawas, Lucas, Adida, Marc, Figuera, Maria, Jakovljević, Miro, Vichi, Monica, Perugi, Giulio, Andreassen, Ole, Vukovic, Olivera, Mavrogiorgou, Paraskevi, Varnik, Peeter, Dome, Peter, Winkler, Petr, Salokangas, Raimo, From, Tiina, Danileviciute, Vita, Gonda, Xenia, Zoltan Rihmer, Forsman, Jonas, Grady, Anne, Hyphantis, Thomas, Dieset, Ingrid, Soendergaard, Susan, Pompili, Maurizio, and Bech, Per

Subjects
ComputingMilieux_THECOMPUTINGPROFESSION, GeneralLiterature_INTRODUCTORYANDSURVEY, ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES, Software_PROGRAMMINGLANGUAGES
Abstract

Additional file 1. Web appendix.

Published
2016
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48. Relationship of suicide rates with climate and economic variables in Europe during 2000-2012

Author

Fountoulakis, Konstantinos N, Chatzikosta, Isaia, Pastiadis, Konstantinos, Zanis, Prodromos, Kawohl, Wolfram, Kerkhof, Ad J F M, Navickas, Alvydas, Höschl, Cyril, Lecic-Tosevski, Dusica, Sorel, Eliot, Rancans, Elmars, Palova, Eva, Juckel, Georg, Isacsson, Goran, Jagodic, Helena Korosec, Botezat-Antonescu, Ileana, Rybakowski, Janusz, Azorin, Jean Michel, Cookson, John, Waddington, John, Pregelj, Peter, Demyttenaere, Koen, Hranov, Luchezar G, Stevovic, Lidija Injac, Pezawas, Lucas, Adida, Marc, Figuera, Maria Luisa, Jakovljević, Miro, Vichi, Monica, Perugi, Giulio, Andreassen, Ole A, Vukovic, Olivera, Mavrogiorgou, Paraskevi, Varnik, Peeter, Dome, Peter, Winkler, Petr, Salokangas, Raimo K R, From, Tiina, Danileviciute, Vita, Gonda, Xenia, Rihmer, Zoltan, Forsman, Jonas, Grady, Anne, Hyphantis, Thomas, Dieset, Ingrid, Soendergaard, Susan, Pompili, Maurizio, Bech, Per, Fountoulakis, Konstantinos N, Chatzikosta, Isaia, Pastiadis, Konstantinos, Zanis, Prodromos, Kawohl, Wolfram, Kerkhof, Ad J F M, Navickas, Alvydas, Höschl, Cyril, Lecic-Tosevski, Dusica, Sorel, Eliot, Rancans, Elmars, Palova, Eva, Juckel, Georg, Isacsson, Goran, Jagodic, Helena Korosec, Botezat-Antonescu, Ileana, Rybakowski, Janusz, Azorin, Jean Michel, Cookson, John, Waddington, John, Pregelj, Peter, Demyttenaere, Koen, Hranov, Luchezar G, Stevovic, Lidija Injac, Pezawas, Lucas, Adida, Marc, Figuera, Maria Luisa, Jakovljević, Miro, Vichi, Monica, Perugi, Giulio, Andreassen, Ole A, Vukovic, Olivera, Mavrogiorgou, Paraskevi, Varnik, Peeter, Dome, Peter, Winkler, Petr, Salokangas, Raimo K R, From, Tiina, Danileviciute, Vita, Gonda, Xenia, Rihmer, Zoltan, Forsman, Jonas, Grady, Anne, Hyphantis, Thomas, Dieset, Ingrid, Soendergaard, Susan, Pompili, Maurizio, and Bech, Per

Abstract

BACKGROUND: It is well known that suicidal rates vary considerably among European countries and the reasons for this are unknown, although several theories have been proposed. The effect of economic variables has been extensively studied but not that of climate.METHODS: Data from 29 European countries covering the years 2000-2012 and concerning male and female standardized suicidal rates (according to WHO), economic variables (according World Bank) and climate variables were gathered. The statistical analysis included cluster and principal component analysis and categorical regression.RESULTS: The derived models explained 62.4 % of the variability of male suicidal rates. Economic variables alone explained 26.9 % and climate variables 37.6 %. For females, the respective figures were 41.7, 11.5 and 28.1 %. Male suicides correlated with high unemployment rate in the frame of high growth rate and high inflation and low GDP per capita, while female suicides correlated negatively with inflation. Both male and female suicides correlated with low temperature.DISCUSSION: The current study reports that the climatic effect (cold climate) is stronger than the economic one, but both are present. It seems that in Europe suicidality follows the climate/temperature cline which interestingly is not from south to north but from south to north-east. This raises concerns that climate change could lead to an increase in suicide rates. The current study is essentially the first successful attempt to explain the differences across countries in Europe; however, it is an observational analysis based on aggregate data and thus there is a lack of control for confounders.

Published
2016

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