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Your search keyword '"Dolotov, Oleg V."' showing total 11 results
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11 results on '"Dolotov, Oleg V."'

5. Composite Coatings Based on Recombinant Spidroins and Peptides with Motifs of the Extracellular Matrix Proteins Enhance Neuronal Differentiation of Neural Precursor Cells Derived from Human Induced Pluripotent Stem Cells

Author

Novosadova, Ekaterina V., primary, Dolotov, Oleg V., additional, Novosadova, Lyudmila V., additional, Davydova, Lubov I., additional, Sidoruk, Konstantin V., additional, Arsenyeva, Elena L., additional, Shimchenko, Darya M., additional, Debabov, Vladimir G., additional, Bogush, Vladimir G., additional, and Tarantul, Vyacheslav Z., additional

Published
2023
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9. Semax, an analog of ACTH(4–10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus

Author

Dolotov, Oleg V., primary, Karpenko, Ekaterina A., additional, Inozemtseva, Lyudmila S., additional, Seredenina, Tamara S., additional, Levitskaya, Natalia G., additional, Rozyczka, Joanna, additional, Dubynina, Elena V., additional, Novosadova, Ekaterina V., additional, Andreeva, Lyudmila A., additional, Alfeeva, Lyudmila Yu., additional, Kamensky, Andrey A., additional, Grivennikov, Igor A., additional, Myasoedov, Nikolay F., additional, and Engele, Jürgen, additional

Published
2006
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11. Effects of behaviorally active ACTH (4–10) analogue – Semax on rat basal forebrain cholinergic neurons.

Author

Grivennikov, Igor A., Dolotov, Oleg V., Zolotarev, Yuri A., Andreeva, Ludmila A., Myasoedov, Nikolai F., Leacher, Lauren, Black, Ira B., and Dreyfus, Cheryl F.

Subjects
*NEURONS, *PROSENCEPHALON, *ALZHEIMER'S disease, *DEMENTIA, *MOLECULES, *ADRENOCORTICOTROPIC hormone, *CEREBROVASCULAR disease
Abstract

PURPOSE. It is well established that cholinergic neurons of the basal forebrain degenerate in Alzheimer's dementia. Although recent studies were concentrated on screening molecules that might reduce the concomitant cell loss, little is known about therapeutically promising molecules. We studied the effect of Semax (Met-Glu-His-Phe-Pro-Gly-Pro), a behaviorally active adrenocorticotropic hormone (4–10) analogue, on survival of cholinergic basal forebrain neurons in vitro. Semax is known to stimulate learning and memory and can be successfully used for treatment of ischemic stroke. METHODS. Primary cultures of neuronal and glial cells from basal forebrain of rats were used in all experiments. The stability of Semax in cell cultures was tested by HPLC analysis. Cell survival in neuronal cultures was quantitated using immocytochemical and cytochemical analyses as well as detection of choline acetyltransferase activity. RESULTS. We have shown that Semax may approximately 1.5–1.7 fold increase survival of cholinergic basal forebrain neurons in vitro. Moreover, Semax (100 nM) stimulated activity of choline acetyltransferase in dissociated basal forebrain tissue cultures. However, the numbers of GABA-ergic neurons, total neuron specific enolase neurons were not affected. In concentration from 1 nM to 10 μM, Semax did not affect proliferation of glial cells in primary cultures. CONCLUSION. Implications of these findings with respect to Alzheimer's disease remain to be clarified. [ABSTRACT FROM AUTHOR]

Published
2008
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