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171 results on '"Dolka I"'

14. Monitored therapy of sporadic mycobacteriosis caused by Mycobacterium genavense in Atlantic canaries (Serinus canaria) and Bengalese finch (Lonchura striata)

Author

Ledwoń Aleksandra, Dolka Izabella, Adamczyk Krzysztof, and Szeleszczuk Piotr

Subjects
avian mycobacteriosis, canary infectious diseases, cryptosporidium galli, mycobacterium genavense, qpcr, Veterinary medicine, SF600-1100
Abstract

Mycobacteriosis is a significant disease of companion and wild birds which causes emaciation and widely distributed lesions, as well as being a potential zoonosis. Its primary aetiological agents in birds are Mycobacterium avium subsp. avium and the fastidious Mycobacterium genavense. This study monitored the therapy of birds naturally infected with Mycobacterium genavense to gain understanding of its effectiveness and the interrelation of co-infections with the disease course and pharmacotherapy.

Published
2021
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15. Mutations of p53 gene in canine sweat gland carcinomas probably associated with UV radiation

Author

Jasik Agnieszka, Kycko Anna, Olech Monika, Wyrostek Krzysztof, Śmiech Anna, Łopuszyński Wojciech, Otrocka-Domagała Iwona, Mikiewicz Mateusz, and Dolka Izabella

Subjects
dog, apocrine sweat gland carcinoma, p53 gene, mutations, uvr, Veterinary medicine, SF600-1100
Abstract

Apocrine sweat gland carcinomas (ASGCs) are rare malignant skin tumours in dogs and humans. The literature published so far focuses mostly on the clinico-epidemiological aspect of these tumours, but little is known about their pathogenesis. In this study we aimed to determine whether the p53 gene is involved in the carcinogenesis of the apocrine sweat gland in dogs and whether ultraviolet radiation (UV) is related to it.

Published
2021
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19. Gene expression profiles in canine mammary carcinomas of various grades of malignancy

Author

Pawlowski, K.M., Maciejewski, R., Dolka, I., Mol, B.W.J., and Universiteit Utrecht

Abstract

Background The frequency of mammary malignancies in canine patients is even three times over than in human. In various types of cancer different intracellular signalling pathways are perturbed, thus the patients with pathologically the same type of cancer often have dissimilar genetic defects in their tumours and respond in a heterogeneous manner to anticancer treatment. That is why the objective of the hereby study was to assess the gene expression profiles in canine mammary carcinomas (in unsupervised manner) classified by pathologists as grade 1 (well differentiated), grade 2 (moderately differentiated) and grade 3 (poorly differentiated) and compare their molecular and pathological classifications. Results Our unsupervised analysis classified the examined tissues into three groups. The first one significantly differed from the others and consisted of four carcinomas of grade 3 and one carcinoma of grade 2. The second group consisted of four grade 1 car cinomas. The very heterogeneous (based on their pathological parameters) group was the last one which consisted of two grade 1 carcinomas, two grade 3 carcinomas and five grade 2 carcinomas. Hierarchical dendrogram showed that the most malignant tumour group had significantly distinct gene expression. Conclusions Molecular classification of canine mammary tumours is not identical with pathological classification. In our opinion molecular and pathological characterization of canine mammary malignancy can complement one another. However, furthers studies in this field are required.

Published
2013

35. Multidrug therapy of Mycobacterium avium subsp. avium infection in experimentally inoculated budgerigars ( Melopsittacus undulatus ).

Author

Ledwoń, A., Dolka, I., Dolka, B., Cegiełkowska, M., Czopowicz, M., and Szeleszczuk, P.

Subjects
*MYCOBACTERIUM avium, *MYCOBACTERIOSIS, *BUDGERIGAR, *POLYPHARMACY, *BIRD diseases, *DISEASES
Abstract

The aim of the study was to determine whether the four-month experimental therapy of mycobacteriosis in budgerigars may cause a complete recovery. A group of nine budgerigars was infected with aMycobacterium aviumsubsp.aviumisolate with proven pathogenicity for budgerigars. Five weeks post-inoculation, multidrug therapy was started. Another group comprising six birds received the same treatment but no infection, and the third group also comprising six birds was kept without infection or treatment as a control. The adopted antibiotic regimen included clarithromycin 61 mg/kg b.w., moxifloxacin 25 mg/kg b.w. and ethambutol 60 mg/kg b.w. administered by crop gavage every 12 h for 18 weeks. Despite a significant improvement in the condition of the infected, treated birds, the four-month therapy was not sufficient for the complete recovery of all. [ABSTRACT FROM PUBLISHER]

Published
2015
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49. Genetic changes in pigeon paramyxovirus type-1 induced by serial passages in chickens and microscopic lesions caused by the virus in various avian hosts

Author

Olszewska-Tomczyk Monika, Dolka Izabella, Świętoń Edyta, and Śmietanka Krzysztof

Subjects
pigeons, poultry, pigeon paramyxovirus type-1, histopathological lesions, high-throughput sequencing, Veterinary medicine, SF600-1100
Abstract

Introduction: Genotype VI of avian avulavirus 1 (AAvV-1) has pigeons and doves as its reservoir and is often termed pigeon paramyxovirus type-1 (PPMV-1). The pathogenesis of PPMV-1 infections in poultry is largely obscure. It is known that PPMV-1 requires a series of passages in chickens before it becomes adapted to gallinaceous poultry.

Published
2018
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