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Your search keyword '"Dolgushina, Nataliya V."' showing total 21 results
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21 results on '"Dolgushina, Nataliya V."'

5. Procoagulant Status and Fibrinolytic Activity in COVID-19 Patients during Illness and Convalescence.

Author

Beznoshchenco, Olga S., Romanov, Andrey Yu., Dolgushina, Nataliya V., Gorodnova, Elena A., Ivanets, Tatiana Yu., Yarotskaya, Ekaterina L., Pyregov, Aleksey V., Grachev, Sergej V., and Sukhikh, Gennady T.

Subjects
COVID-19 pandemic, COVID-19, MULTIPLE organ failure, CONVALESCENCE, SARS-CoV-2
Abstract

SARS-CoV-2 (Severe Acute Respiratory Syndrome-related CoronaVirus 2) activates the immune system, causing thrombin dysregulation and tissue damage and reduces endothelium anticoagulant function, leading to excessive thrombin formation. Hypercoagulability, which causes multiple organ failure in critically ill COVID-19 (COronaVIrus Disease 2019) patients, can be detected by viscoelastic tests like thromboelastography and rotational thromboelastometry (ROTEM). We aimed to assess the coagulation system status and fibrinolytic activity using ROTEM thromboelastometry in patients with COVID-19 and convalescents. The observational prospective study included 141 patients with COVID-19: Group 1—patients with mild (n = 39), Group 2—patients with moderate (n = 65), and Group 3—patients with severe (n = 37) COVID-19. The coagulation status was assessed twice—during the disease and in convalescence. The male gender, age > 56 years, overweight, and obesity were risk factors for developing severe COVID-19. During the disease in patients with moderate and severe COVID-19, the hemostatic system was characterized by a procoagulant status, which persists during the period of convalescence. Fibrinolysis shutdown was detected in both moderate and severe patients with COVID-19. The procoagulant status of the coagulation system and the shutdown of fibrinolysis are typical for patients with moderate to severe COVID-19. In convalescents, activation of coagulation remains, which indicates the need to monitor the hemostatic system after Illness. [ABSTRACT FROM AUTHOR]

Published
2024
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9. The use of the thrombodynamics test in the diagnostics of hemostasis disorders in patients with COVID-19 of varying severity

Author

Krechetova, Liubov V., primary, Nechipurenko, Dmitry Yu., additional, Shpilyuk, Margarita A., additional, Beznoshchenko, Olga S., additional, Beresneva, Evgeniya A., additional, Markelov, Mikhail I., additional, Ivanets, Tatiana Yu., additional, Gavrilova, Tatiana Yu., additional, Kozachenko, Irena F., additional, Esayan, Rosa M., additional, Pyregov, Aleksei V., additional, Khachatryan, Nelly A., additional, Kodatskii, Dmitrii S., additional, Spiridonov, Ilya S., additional, Dolgushina, Nataliya V., additional, Gorodnova, Elena A., additional, Ataullakhanov, Fazoil I., additional, Rumyantsev, Alexander G., additional, and Degtyarev, Dmitriy N., additional

Published
2021
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11. SARS-CoV-2 Peptide Bioconjugates Designed for Antibody Diagnostics

Author

Ryzhov, Ivan M., primary, Tuzikov, Alexander B., additional, Nizovtsev, Alexey V., additional, Baidakova, Ludmila K., additional, Galanina, Oxana E., additional, Shilova, Nadezhda V., additional, Ziganshina, Marina M., additional, Dolgushina, Nataliya V., additional, Bayramova, Guldana R., additional, Sukhikh, Gennady T., additional, Williams, Eleanor C., additional, Nagappan, Radhika, additional, Henry, Stephen M., additional, and Bovin, Nicolai V., additional

Published
2021
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12. Additional file 2 of Epithelial apical glycosylation changes associated with thin endometrium in women with infertility - a pilot observational study

Author

Ziganshina, Marina M., Dolgushina, Nataliya V., Kulikova, Galina V., Fayzullina, Nafisa M., Yarotskaya, Ekaterina L., Khasbiullina, Nailia R., Abdurakhmanova, Nigora F., Asaturova, Aleksandra V., Shchegolev, Alexander I., Dovgan, Alina A., and Sukhikh, Gennady T.

Subjects
urogenital system, female genital diseases and pregnancy complications, reproductive and urinary physiology
Abstract

Additional file 2: Table S2. Glycoconjugates contents on the apical surface of the luminal and glandular epithelial cells in patients with “thin” endometrium (group 1) and patients with normal endometrium (group 2).

Published
2021
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13. Additional file 1 of Epithelial apical glycosylation changes associated with thin endometrium in women with infertility - a pilot observational study

Author

Ziganshina, Marina M., Dolgushina, Nataliya V., Kulikova, Galina V., Fayzullina, Nafisa M., Yarotskaya, Ekaterina L., Khasbiullina, Nailia R., Abdurakhmanova, Nigora F., Asaturova, Aleksandra V., Shchegolev, Alexander I., Dovgan, Alina A., and Sukhikh, Gennady T.

Subjects
carbohydrates (lipids)
Abstract

Additional file 1: Table S1. The list of glycans. This Table represents all glycans (oligo- and polysaccharides) printed on microarrays used in this work.

Published
2021
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21. The role of extracellular inducer of matrix metalloproteinases in premature rupture of membranes.

Author

Sukhikh, Gennady T., Kan, Natalia E., Tyutyunnik, Victor L., Sannikova, Maya V., Dubova, Elena A., Pavlov, Konstantin A., Amiraslanov, Elrad Y., and Dolgushina, Nataliya V.

Subjects
PREMATURE rupture of fetal membranes, MATRIX metalloproteinases, DELIVERY (Obstetrics), PREGNANCY, IMMUNOGLOBULINS, AMNION, EPITHELIAL cells, EPITHELIUM, IMMUNOHISTOCHEMISTRY, PREGNANCY complications, PROTEOLYTIC enzymes, CROSS-sectional method
Abstract

Objective: To investigate the role of matrix metalloproteinases (MMP-2, MMP-9) and their inducer (CD147) in premature rupture of membranes (PROM) at term labor.Methods: In a cross-sectional study, 24 women aged 19-39, with 37-40-week pregnancy, and no clinical and histological signs of chorioamnionitis, were divided into two groups with and without PROM. The histological and immunohistochemical study of the fetal membranes was performed with polyclonal rabbit antibodies to MMP-2/MMP-9 and monoclonal rabbit antibodies to CD147.Results: The analysis of MMP revealed the increase of MMP-9 expression in the amniotic epithelium during premature membrane rupture both in rupture area, and beyond it, and increased MMR-2 expression in the mesodermal cells. We also found high level of CD147 in the amniotic epithelium in PROM group. The above-mentioned changes were found in all areas of fetal membranes, regardless of the rupture localization.Conclusions: The study results demonstrate the increased expression of MMR-2 and MMR-9, which regulate the catabolism of fetal membrane extracellular matrix proteins, in amniotic membranes of women with PROM at term labor. The increased expression of CD147 may be one of the mechanisms triggering PROM in the absence of infection. [ABSTRACT FROM AUTHOR]

Published
2016
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