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11 results on '"Dolatyari, Vahideh"'

8. Luminescent Heterobimetallic PtII–AuIComplexes Bearing N-Heterocyclic Carbenes (NHCs) as Potent Anticancer Agents

Author

Dolatyari, Vahideh, Shahsavari, Hamid R., Fereidoonnezhad, Masood, Farhadi, Fahimeh, Akhlaghi, Shiva, Latouche, Camille, Sakamaki, Yoshie, and Beyzavi, Hudson

Abstract

This study aims to probe into new series of heterobimetallic PtII–AuIcomplexes with a general formula of [Pt(p-MeC6H4)(dfppy)(μ-dppm)Au(NHC)]OTf, NHC = IPr, 2; IMes, 3; dfppy = 2-(2,4-difluorophenyl)pyridinate; dppm = 1,1-bis(diphenylphosphino)methane, which are the resultant of the reaction between [Pt(p-MeC6H4)(dfppy)(κ1-dppm)], 1, with [AuCl(NHC)], NHC = IPr, B; IMes, C, in the presence of [Ag(OTf)]. In the heterobimetallic complexes, the dppm ligand is settled between both metals as an unsymmetrical bridging ligand. Several techniques are employed to characterize the resulting compounds. Moreover, the photophysical properties of the complexes are investigated by means of UV–vis and photoluminescence spectroscopy. Furthermore, the experimental study is enriched by ab initio calculations (density functional theory (DFT) and time-dependent DFT (TD-DFT)) to assess the role of Pt and Au moieties in the observed optical properties. It is revealed that 1–3is luminescent in the solid state and solution at different temperatures. In addition, the achieved results indicate the emissive properties of 1–3are originated from a mixed 3IL/3MLCT excited state with major contribution of intraligand charge transfer (dfppy). A comparative study is conducted into the cytotoxic activities of starting materials and 1–3against different human cancer cell lines such as the pancreas (MIA-PaCa2), breast (MDA-MB-231), cervix (HeLa), and noncancerous breast epithelial cell line (MCF-10A). The achieved results suggest the heterobimetallic PtII–AuIspecies as optimal compounds that signify the existence of cooperative and synergistic effects in their structures. The complex 3is considered as the most cytotoxic compound with the maximum selectivity index in our screened complex series. Moreover, it is disclosed that 3effectively causes cell death by inducing apoptosis in MIA-PaCa2 cells. Furthermore, the finding results by fluorescent cell microscopy manifest cytoplasmic staining of 3rather than nucleus.

Published
2023
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9. Phosphorescent cyclometalated Ir(iii) complexes comprising chelating thiolate ligands as pH-activatable sensors

Author

Institute for Advanced Studies in Basic Sciences (Iran), Iran Science Elites Federation, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Gobierno de Aragón, European Commission, Paziresh, Sareh, Babadi Aghakhanpour, Reza, Shahsavari, Hamid R., Dolatyari, Vahideh, Ara, Irene, Masoud Nabavizadeh, Seyed, Institute for Advanced Studies in Basic Sciences (Iran), Iran Science Elites Federation, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Gobierno de Aragón, European Commission, Paziresh, Sareh, Babadi Aghakhanpour, Reza, Shahsavari, Hamid R., Dolatyari, Vahideh, Ara, Irene, and Masoud Nabavizadeh, Seyed

Abstract

A series of cyclometalated Ir(III) complexes possessing the general formula of [Ir(pqe)2(S^N)], pqe = 2-phenyl-quinoline-4-carboxylic acid methyl ester, S^N = pyridine-2-thiolate (Spy, B1); pyrimidine-2-thiolate (SpyN, B2); 5-(trifluoromethyl)-pyridine-2-thiolate (SpyCF3, B3); 2-thiazoline-2-thiolate (Stz, B4) and benzothiazole-2-thiolate (SBt, B5), were synthesized and characterized using several spectroscopies and analytical techniques. These compounds were photophysically investigated using UV-Vis absorption and photoluminescence spectroscopies. The complexes demonstrate strong red emissions in their CH2Cl2 solutions at 298 K but with different quantum efficiencies (B3 > B2 > B1 > B5 > B4). The emissions majorly originate from a 3MLCT (metal to ligand charge transfer) character along with smaller contributions of 3ILCT (intra ligand charge transfer) and 3L′LCT (ligand to ligand charge transfer; L = pqe, L′ = S^N). The esteric functional group (COOMe) on the pqe ligand can be easily converted to COO−Na+ in a hydrolysis process, resulting in the corresponding complexes [Na2{Ir(pqc)2(S^N)}], S^N = Spy, C1; SpyN, C2; SpyCF3, C3, being very water-soluble. Based on this hydrolysis, a large blue-shift is observed for the emissions of C1–C3 compared to B1–B5 which is supported by density functional theory (DFT) calculations. Also, the emission intensity of these complexes is sensitive to pH and steadily increases with the pH of solutions. The lifetime values as the other function of emission is changed by varying the pH values, wherein the graphs of lifetime/pH become quasi-linear. The slopes of the lines, as an index for the pH-sensitivity property, demonstrate the trend of C3 > C2 > C1 for the pH sensitivity of the complexes.

Published
2022

11. Luminescent Heterobimetallic Pt II -Au I Complexes Bearing N -Heterocyclic Carbenes (NHCs) as Potent Anticancer Agents.

Author

Dolatyari V, Shahsavari HR, Fereidoonnezhad M, Farhadi F, Akhlaghi S, Latouche C, Sakamaki Y, and Beyzavi H

Subjects
Humans, Methane pharmacology, HeLa Cells, Spectrum Analysis methods, Antineoplastic Agents pharmacology
Abstract

This study aims to probe into new series of heterobimetallic Pt II -Au I complexes with a general formula of [Pt( p -MeC 6 H 4 )(dfppy)(μ-dppm)Au(NHC)]OTf, NHC = IPr, 2 ; IMes, 3 ; dfppy = 2-(2,4-difluorophenyl)pyridinate; dppm = 1,1-bis(diphenylphosphino)methane, which are the resultant of the reaction between [Pt( p -MeC 6 H 4 )(dfppy)(κ 1 -dppm)], 1 , with [AuCl(NHC)], NHC = IPr, B ; IMes, C , in the presence of [Ag(OTf)]. In the heterobimetallic complexes, the dppm ligand is settled between both metals as an unsymmetrical bridging ligand. Several techniques are employed to characterize the resulting compounds. Moreover, the photophysical properties of the complexes are investigated by means of UV-vis and photoluminescence spectroscopy. Furthermore, the experimental study is enriched by ab initio calculations (density functional theory (DFT) and time-dependent DFT (TD-DFT)) to assess the role of Pt and Au moieties in the observed optical properties. It is revealed that 1 - 3 is luminescent in the solid state and solution at different temperatures. In addition, the achieved results indicate the emissive properties of 1 - 3 are originated from a mixed 3 IL/ 3 MLCT excited state with major contribution of intraligand charge transfer (dfppy). A comparative study is conducted into the cytotoxic activities of starting materials and 1 - 3 against different human cancer cell lines such as the pancreas (MIA-PaCa2), breast (MDA-MB-231), cervix (HeLa), and noncancerous breast epithelial cell line (MCF-10A). The achieved results suggest the heterobimetallic Pt II -Au I species as optimal compounds that signify the existence of cooperative and synergistic effects in their structures. The complex 3 is considered as the most cytotoxic compound with the maximum selectivity index in our screened complex series. Moreover, it is disclosed that 3 effectively causes cell death by inducing apoptosis in MIA-PaCa2 cells. Furthermore, the finding results by fluorescent cell microscopy manifest cytoplasmic staining of 3 rather than nucleus.

Published
2023
Full Text
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