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6. Trends in CVD Risk Factors for Youth with Incident Diabetes: SEARCH for Diabetes in Youth.

Author

Bell, Ronny A., Rigdon, Joseph, Bellatorre, Anna, Dabelea, Dana, D'Agostino, Ralph, Divers, Jasmin, Dolan, Lawrence M., Jensen, Elizabeth, Liese, Angela D., Lustigova, Eva, Marcovina, Santica M., Merjaneh, Lina, Pettitt, David J., Pihoker, Catherine, Shah, Amy S., South, Andrew M., Wagenknecht, Lynne E., and Hoffman, Robert P.

Subjects
CARDIOVASCULAR disease related mortality, PREDIABETIC state, KIDNEY function tests, CROSS-sectional method, EARLY medical intervention, BODY mass index, LIPIDS, SEX distribution, LOGISTIC regression analysis, CARDIOVASCULAR diseases risk factors, CAUSES of death, DESCRIPTIVE statistics, LONGITUDINAL method, WAIST circumference, AGE factors in disease, RACE, CYSTATINS, ODDS ratio, RESEARCH methodology, DIASTOLIC blood pressure, DATA analysis software, DIABETES, REGRESSION analysis, GLOMERULAR filtration rate, BIOMARKERS, TIME, ADOLESCENCE
Abstract

Objectives. Cardiovascular disease (CVD) is the leading cause of death and disability among persons with diabetes. Early intervention on cardiovascular risk factors (CRFs) is important in reducing CVD burden. The SEARCH for Diabetes in Youth study assessed CRFs in incident cohorts of youth aged <20 years established from 2002 to 2016. Research Design and Methods. Regression models assessed trends over each incident year for lipids (total cholesterol (TC), HDL‐c, LDL‐c, triglycerides (TG), VLDL‐c, and non‐HDL‐c), kidney function (albumin/creatinine ratio (ACR) ≥30 and ≥300, cystatin C, serum creatinine and estimated glomerular filtration rate (eGFR)), systolic and diastolic blood pressure (BP) z‐scores, BMI z‐score, waist circumference (WC), and an inflammatory marker (C‐reactive protein (CRP)). Models were stratified by diabetes type (type 1 diabetes (T1D), N = 4,600; type 2 diabetes (T2D), N = 932) and adjusted for age at diagnosis, sex, race/ethnicity, and diabetes duration. An interaction analysis assessed differential time trends by type. Results. For youth with T1D, all CRFs significantly improved over time, with the exception of ACR > 300, cystatin C, serum creatinine, eGFR, and CRP. For youth with T2D, TC, LDL‐c, and non‐HDL‐c significantly improved, while eGFR, BMI z‐score, and CRP significantly worsened. Significant differences in trends over time by type were seen for TC, HDL‐c, BMI z‐score, BP z‐scores, WC, and CRP. Conclusions. Overall, improvements in CRFs were more often observed in youth with T1D. Youth with T2D had worsening trends over time in BMI z‐score, CRP, and kidney function. Further research is needed to better understand these trends and their implications for long‐term CVD risk. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Household Food Insecurity Is Associated With Physical Activity in Youth and Young Adults With Diabetes: A Cross-Sectional Study

Author

Reid, Lauren A., primary, Geraci, Marco, additional, Mendoza, Jason A., additional, Merchant, Anwar T., additional, Reboussin, Beth A., additional, Pate, Russell R., additional, Dolan, Lawrence M., additional, Sauder, Katherine A., additional, Lustigova, Eva, additional, Kim, Grace, additional, and Liese, Angela D., additional

Published
2024
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9. Diabetes Stigma and Psychosocial Outcomes in Adolescents and Young Adults: The SEARCH for Diabetes in Youth Study

Author

Eitel, Kelsey B., primary, Roberts, Alissa J., additional, D’Agostino, Ralph, additional, Barrett, Catherine E., additional, Bell, Ronny A., additional, Bellatorre, Anna, additional, Cristello, Angelica, additional, Dabelea, Dana, additional, Dolan, Lawrence M., additional, Jensen, Elizabeth T., additional, Liese, Angela D., additional, Reynolds, Kristi, additional, Marcovina, Santica M., additional, and Pihoker, Catherine, additional

Published
2023
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10. Self-Reported Food Security in Adolescents with Type 1 Diabetes: Association with Hemoglobin A1c and Mental Health Symptoms Independent of Household Food Security

Author

Julceus, Emmanuel F., primary, Frongillo, Edward A., additional, Mendoza, Jason A., additional, Sauder, Katherine A., additional, Malik, Faisal S., additional, Jensen, Elizabeth T., additional, Dolan, Lawrence M., additional, Bellatorre, Anna, additional, Dabelea, Dana, additional, Reboussin, Beth A., additional, Reynolds, Kristi, additional, Pihoker, Catherine, additional, and Liese, Angela D., additional

Published
2023
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11. Insulin pump use and glycemic control in adolescents with type 1 diabetes: Predictors of change in method of insulin delivery across two years

Author

Wong, Jenise C, Dolan, Lawrence M, Yang, Tony T, and Hood, Korey K

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Brain Disorders, Autoimmune Disease, Mental Health, Depression, Pediatric, Diabetes, Metabolic and endocrine, Adolescent, Blood Glucose, Diabetes Mellitus, Type 1, Female, Humans, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Longitudinal Studies, Male, adolescent, depression, diabetes mellitus, insulin pump, type 1 diabetes, Paediatrics and Reproductive Medicine, Endocrinology & Metabolism, Clinical sciences, Paediatrics
Abstract

Few studies have explored durability of insulin pump use, and none have explored the link between depression and pump discontinuation. To examine the relationship between depressive symptoms [measured by the Children's Depression Inventory (CDI)], method of insulin delivery, and hemoglobin A1c (A1c), mixed models were used with data from 150 adolescents with type 1 diabetes (T1D) and visits every 6 months for 2 years. Of the 63% who used a pump, compared with multiple daily injections (MDI) at baseline, there were higher proportions who were non-minorities, had caregivers with a college degree, private insurance, and two caregivers in the home (p ≤ 0.01). After adjusting for time, sex, age, T1D duration, frequency of blood glucose monitoring, ethnicity, insurance, and caregiver number and education, baseline pump use was associated with -0.79% lower mean A1c [95% confidence interval (CI): -1.48, -0.096; p = 0.03]. For those using a pump at baseline, but switching to MDI during the study (n = 9), mean A1c was 1.38% higher (95% CI: 0.68, 2.08; p < 0.001) than that for those who did not switch method of delivery. A 10-point increase in CDI was associated with a 0.39% increase in A1c (95% CI: 0.16, 0.61; p = 0.001), independent of pump use. Regarding the temporal relationship between CDI score and changing method of insulin delivery, prior higher CDI score was associated with switching from pump to MDI (odds ratio = 1.21; 95% CI: 1.05, 1.39; p = 0.007). Clinicians should be aware of the associations between depressive symptoms, change in insulin delivery method, and the effect on glycemic control.

Published
2015

12. Type 1 diabetes is associated with an increase in cholesterol absorption markers but a decrease in cholesterol synthesis markers in a young adult population

Author

Semova, Ivana, Levenson, Amy E., Krawczyk, Joanna, Bullock, Kevin, Williams, Kathryn A., Wadwa, R. Paul, Shah, Amy S., Khoury, Philip R., Kimball, Thomas R., Urbina, Elaine M., de Ferranti, Sarah D., Bishop, Franziska K., Maahs, David M., Dolan, Lawrence M., Clish, Clary B., and Biddinger, Sudha B.

Published
2019
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13. Household Food Insecurity and Cognition in Youth and Young Adults with Youth-Onset Diabetes

Author

Brown, Andrea D., primary, Liese, Angela D., additional, Shapiro, Allison L. B., additional, Frongillo, Edward A., additional, Wilkening, Greta, additional, Fridriksson, Julius, additional, Merchant, Anwar T., additional, Henkin, Leora, additional, Jensen, Elizabeth T., additional, Reboussin, Beth A., additional, Shah, Amy S., additional, Marcovina, Santica, additional, Dolan, Lawrence M., additional, Dabelea, Dana, additional, Pihoker, Catherine, additional, and Mendoza, Jason A., additional

Published
2023
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17. Diabetes Stigma and Psychosocial Outcomes in Adolescents and Young Adults: The SEARCH for Diabetes in Youth Study.

Author

Eitel, Kelsey B., Roberts, Alissa J., D’Agostino Jr., Ralph, Barrett, Catherine E., Bell, Ronny A., Bellatorre, Anna, Cristello, Angelica, Dabelea, Dana, Dolan, Lawrence M., Jensen, Elizabeth T., Liese, Angela D., Reynolds, Kristi, Marcovina, Santica M., and Pihoker, Catherine

Subjects
YOUNG adults, TYPE 1 diabetes, TYPE 2 diabetes, SOCIAL stigma, TEENAGERS
Abstract

OBJECTIVE: To examine the association between diabetes stigma, socioeconomic status, psychosocial variables, and substance use in adolescents and young adults (AYAs) with type 1 or type 2 diabetes. RESEARCH DESIGN AND METHODS: This is a cross-sectional analysis of AYAs from the SEARCH for Diabetes in Youth study who completed a survey on diabetes-related stigma, generating a total diabetes stigma score. Using multivariable modeling, stratified by diabetes type, we examined the relationship of diabetes stigma with variables of interest. RESULTS: Of the 1,608 AYAs who completed the diabetes-related stigma survey, 78% had type 1 diabetes, and the mean age was 21.7 years. Higher diabetes stigma scores were associated with food insecurity (P = 0.001), disordered eating (P < 0.0001), depressive symptoms (P < 0.0001), and decreased health-related (P < 0.0001) and diabetes-specific quality of life (P < 0.0001). CONCLUSIONS: Diabetes stigma is associated with food insecurity, disordered eating, and lower psychosocial well-being. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Prevalence, Progression, and Modifiable Risk Factors for Diabetic Retinopathy in Youth and Young Adults With Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study

Author

Jensen, Elizabeth T., primary, Rigdon, Joseph, additional, Rezaei, Kasra A., additional, Saaddine, Jinan, additional, Lundeen, Elizabeth A., additional, Dabelea, Dana, additional, Dolan, Lawrence M., additional, D’Agostino, Ralph, additional, Klein, Barbara, additional, Meuer, Stacy, additional, Mefford, Matthew T., additional, Reynolds, Kristi, additional, Marcovina, Santica M., additional, Mottl, Amy, additional, Mayer-Davis, Beth, additional, and Lawrence, Jean M., additional

Published
2023
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20. Exploring Racial and Ethnic Differences in Arterial Stiffness Among Youth and Young Adults With Type 1 Diabetes

Author

Sauder, Katherine A., primary, Glueck, Deborah H., additional, Harrall, Kylie K., additional, D'Agostino, Ralph, additional, Dolan, Lawrence M., additional, Lane, Abbi D., additional, Liese, Angela D., additional, Lustigova, Eva, additional, Malik, Faisal S., additional, Marcovina, Santica, additional, Mayer‐Davis, Elizabeth, additional, Mottl, Amy, additional, Pihoker, Catherine, additional, Reynolds, Kristi, additional, Shah, Amy S., additional, Urbina, Elaine M., additional, Wagenknecht, Lynne E., additional, Daniels, Stephen R., additional, and Dabelea, Dana, additional

Published
2023
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21. Diabetes Stigma and Clinical Outcomes in Adolescents and Young Adults: The SEARCH for Diabetes in Youth Study

Author

Eitel, Kelsey B., primary, Roberts, Alissa J., additional, D’Agostino, Ralph, additional, Barrett, Catherine E., additional, Bell, Ronny A., additional, Bellatorre, Anna, additional, Cristello, Angelica, additional, Dabelea, Dana, additional, Dolan, Lawrence M., additional, Jensen, Elizabeth T., additional, Liese, Angela D., additional, Mayer-Davis, Elizabeth J., additional, Reynolds, Kristi, additional, Marcovina, Santica M., additional, and Pihoker, Catherine, additional

Published
2023
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24. Self-Reported Food Security in Adolescents with Type 1 Diabetes: Association with Hemoglobin A1cand Mental Health Symptoms Independent of Household Food Security

Author

Julceus, Emmanuel F, Frongillo, Edward A, Mendoza, Jason A, Sauder, Katherine A, Malik, Faisal S, Jensen, Elizabeth T, Dolan, Lawrence M, Bellatorre, Anna, Dabelea, Dana, Reboussin, Beth A, Reynolds, Kristi, Pihoker, Catherine, and Liese, Angela D

Abstract

Typically, child exposure to food insecurity is assessed by caregiver reports of household food security. Child report has the potential for greater accuracy because it pertains only to the child whose experiences may differ from caregiver reports.

Published
2024
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26. Association of Elevated Arterial Stiffness with Cardiac Target Organ Damage and Cardiac Autonomic Neuropathy in Young Adults with Diabetes: The SEARCH for Diabetes in Youth Study

Author

Urbina, Elaine M., primary, Isom, Scott, primary, Dabelea, Dana, primary, Jr., Ralph D’Agostino,, primary, Daniels, Stephen R., primary, Dolan, Lawrence M., primary, Imperatore, Giuseppina, primary, Lustigova, Eva, primary, Marcovina, Santica, primary, Mottl, Amy, primary, Pihoker, Catherine, primary, and Shah, Amy S, primary

Published
2023
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32. The Frequency of Undiagnosed Celiac Disease in Youth with Type 1 Diabetes and Its Association with Diabetic Retinopathy: The SEARCH for Diabetes in Youth Study

Author

Brady, Ryan P., Jensen, Elizabeth T., Rigdon, Joseph, Crimmins, Nancy A., Mallon, Daniel, Dolan, Lawrence M., Imperatore, Giuseppina, Kahkoska, Anna R., Mottl, Amy K., Honor, Ann, Pettitt, David J., Merjaneh, Lina, Dabelea, Dana, and Shah, Amy S.

Abstract

Aims. Celiac disease (CD) in adults with type 1 diabetes has been associated with increased cardiovascular risk and the earlier occurrence of diabetes-associated complications. In the Search for Diabetes in Youth study, we aimed to assess the frequency of CD and the potential for undiagnosed CD among youth with childhood onset type 1 diabetes. In addition, we assessed the burden of cardiovascular risk factors and diabetes-associated complications in youth with type 1 diabetes by CD status and IgA tissue transglutaminase autoantibody (tTGA) levels. Methods. 2,444 youths with type 1 diabetes completed a CD questionnaire and underwent tTGA testing. Integrating the celiac disease questionnaire and tTGA results for this cross-sectional analysis, participants were categorized as follows: (1) reported CD; (2) seropositive for CD (no reported CD and seropositive tTGA); and (3) type 1 diabetes only (comparison group: no reported CD and seronegative tTGA). Subanalyses were performed on those with no reported CD and tTGA ≥10x ULN, designated potentially undiagnosed CD. Cardiovascular risk factors and diabetes-associated complications were evaluated by CD status and tTGA levels utilizing a Poisson model to estimate relative risk. Results. Reported CD in youths with type 1 diabetes was 7%. Seropositivity for tTGA with no reported CD was present in 4%, and 1.2% had potentially undiagnosed CD. Youths with potentially undiagnosed CD had a 2.69x higher risk of diabetic retinopathy than comparison group. In addition, CD with tTGA

Published
2023
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33. Changes in Bone Marrow Adipose Tissue in Transgender and Gender Non-Conforming Youth Undergoing Pubertal Suppression: A Pilot Study

Author

Nasomyont, Nat, primary, Meisman, Andrea R., additional, Ecklund, Kirsten, additional, Vajapeyam, Sridhar, additional, Cecil, Kim M., additional, Tkach, Jean A., additional, Altaye, Mekibib, additional, Corathers, Sarah D., additional, Conard, Lee Ann, additional, Kalkwarf, Heidi J., additional, Dolan, Lawrence M., additional, and Gordon, Catherine M., additional

Published
2022
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38. A longitudinal assessment of diabetes autoantibodies in the SEARCH for diabetes in youth study

Author

Merjaneh, Lina, primary, Dolan, Lawrence M., additional, Suerken, Cynthia K., additional, D'Agostino, Ralph, additional, Imperatore, Giuseppina, additional, Saydah, Sharon, additional, Roberts, Alissa, additional, Marcovina, Santica, additional, Mayer‐Davis, Elizabeth J., additional, Dabelea, Dana, additional, Lawrence, Jean M., additional, and Pihoker, Catherine, additional

Published
2022
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39. Household Food Insecurity and Fear of Hypoglycemia in Adolescents and Young Adults with Diabetes and Parents of Youth with Diabetes

Author

Reid, Lauren A., primary, Zheng, Siyu, primary, Mendoza, Jason A., primary, Reboussin, Beth A., primary, Roberts, Alissa, primary, Sauder, Katherine A., primary, Lawrence, Jean M., primary, Jensen, Elizabeth, primary, Henkin, Leora, primary, Flory, Kate, primary, Knight, Lisa, primary, Pihoker, Catherine, primary, Dolan, Lawrence M., primary, Apperson, Elaine, primary, and Liese, Angela D., primary

Published
2022
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41. Longitudinal Changes in Arterial Stiffness and Heart Rate Variability in Youth-Onset Type 1 Versus Type 2 Diabetes: The SEARCH for Diabetes in Youth Study

Author

Shah, Amy S., primary, Isom, Scott, additional, D’Agostino, Ralph, additional, Dolan, Lawrence M., additional, Dabelea, Dana, additional, Imperatore, Giuseppina, additional, Mottl, Amy, additional, Lustigova, Eva, additional, Pihoker, Catherine, additional, Marcovina, Santica, additional, and Urbina, Elaine M., additional

Published
2022
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42. 345-OR: Longitudinal Changes in Arterial Stiffness and Heart Rate Variability in Youth-Onset Type 1 vs. Type 2 Diabetes

Author

SHAH, AMY S., primary, ISOM, SCOTT, additional, DAGOSTINO, RALPH, additional, DOLAN, LAWRENCE M., additional, DABELEA, DANA, additional, IMPERATORE, GIUSEPPINA, additional, MOTTL, AMY K., additional, LUSTIGOVA, EVA, additional, PIHOKER, CATHERINE, additional, MARCOVINA, SANTICA M., additional, and URBINA, ELAINE M., additional

Published
2022
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43. 53-OR: Diabetes Stigma and Clinical Outcomes in Adolescents and Young Adults: The SEARCH for Diabetes in Youth Study

Author

EITEL, KELSEY B., primary, ROBERTS, ALISSA J., additional, DAGOSTINO, RALPH, additional, BELL, RONNY A., additional, BELLATORRE, ANNA, additional, BARRETT, CATHERINE E., additional, CRISTELLO, ANGELICA, additional, DABELEA, DANA, additional, DOLAN, LAWRENCE M., additional, JENSEN, ELIZABETH T., additional, LIESE, ANGELA D., additional, MARCOVINA, SANTICA M., additional, MAYER-DAVIS, ELIZABETH J., additional, REYNOLDS, KRISTI, additional, and PIHOKER, CATHERINE, additional

Published
2022
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44. 1084-P: Trends in Cardiovascular Risk Factors (CRF) for Youth with Incident Diabetes: The SEARCH for Diabetes in Youth Study

Author

BELL, RONNY A., primary, RIGDON, JOSEPH, additional, BELLATORRE, ANNA, additional, DABELEA, DANA, additional, DAGOSTINO, RALPH, additional, DIVERS, JASMIN, additional, DOLAN, LAWRENCE M., additional, IMPERATORE, GIUSEPPINA, additional, JENSEN, ELIZABETH T., additional, LIESE, ANGELA D., additional, LUSTIGOVA, EVA, additional, MARCOVINA, SANTICA M., additional, MERJANEH, LINA, additional, PETTITT, DAVID J., additional, PIHOKER, CATHERINE, additional, SHAH, AMY S., additional, SOUTH, ANDREW M., additional, and WAGENKNECHT, LYNNE E., additional

Published
2022
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45. 1085-P: Exploring Racial and Ethnic Disparities in Arterial Stiffness in Type 1 Diabetes

Author

SAUDER, KATHERINE A., primary, GLUECK, DEBORAH H., additional, HARRALL, KYLIE K., additional, DAGOSTINO, RALPH, additional, DOLAN, LAWRENCE M., additional, LANE-CORDOVA, ABBI, additional, LIESE, ANGELA D., additional, LUSTIGOVA, EVA, additional, MALIK, FAISAL, additional, MARCOVINA, SANTICA M., additional, MAYER-DAVIS, ELIZABETH J., additional, MOTTL, AMY K., additional, PIHOKER, CATHERINE, additional, REYNOLDS, KRISTI, additional, SHAH, AMY S., additional, URBINA, ELAINE M., additional, WAGENKNECHT, LYNNE E., additional, DANIELS, STEPHEN R., additional, and DABELEA, DANA, additional

Published
2022
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46. 1-LB: Trends in Incidence and Age at Diagnosis of Youth-Onset Type 2 Diabetes, 2002–2018—The SEARCH for Diabetes in Youth Study

Author

SAUDER, KATHERINE A., primary, WAGENKNECHT, LYNNE E., additional, LIESE, ANGELA D., additional, DABELEA, DANA, additional, MARCOVINA, SANTICA M., additional, PIHOKER, CATHERINE, additional, REYNOLDS, KRISTI, additional, SHAH, AMY S., additional, DOLAN, LAWRENCE M., additional, BELLATORRE, ANNA, additional, LAWRENCE, JEAN M., additional, DIVERS, JASMIN, additional, and JENSEN, ELIZABETH T., additional

Published
2022
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47. 102-OR: Association of Elevated Arterial Stiffness with Cardiac Target Organ Damage in Young Adults with Diabetes: The Search for Diabetes in Youth Study

Author

URBINA, ELAINE M., primary, ISOM, SCOTT, additional, DABELEA, DANA, additional, DAGOSTINO, RALPH, additional, DANIELS, STEPHEN R., additional, DOLAN, LAWRENCE M., additional, IMPERATORE, GIUSEPPINA, additional, LUSTIGOVA, EVA, additional, MARCOVINA, SANTICA M., additional, MOTTL, AMY K., additional, PIHOKER, CATHERINE, additional, and SHAH, AMY S., additional

Published
2022
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49. 570-P: Household Food Insecurity, Stress, and Anxiety among Youth and Young Adults with Diabetes

Author

BROWN, ANDREA D., primary, MENDOZA, JASON A., additional, FRONGILLO, EDWARD A., additional, FLORY, KATE, additional, REBOUSSIN, BETH A., additional, JENSEN, ELIZABETH T., additional, DOLAN, LAWRENCE M., additional, BELLATORRE, ANNA, additional, MALIK, FAISAL, additional, MARCOVINA, SANTICA M., additional, PIHOKER, CATHERINE, additional, and LIESE, ANGELA D., additional

Published
2022
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50. 597-P: Diabetes Stigma, Sociodemographics, and Psychosocial Outcomes in Adolescents and Young Adults: The SEARCH for Diabetes in Youth Study

Author

EITEL, KELSEY B., primary, ROBERTS, ALISSA J., additional, DAGOSTINO, RALPH, additional, BELL, RONNY A., additional, BELLATORRE, ANNA, additional, BARRETT, CATHERINE E., additional, CRISTELLO, ANGELICA, additional, DABELEA, DANA, additional, DOLAN, LAWRENCE M., additional, JENSEN, ELIZABETH T., additional, LIESE, ANGELA D., additional, MARCOVINA, SANTICA M., additional, MAYER-DAVIS, ELIZABETH J., additional, REYNOLDS, KRISTI, additional, and PIHOKER, CATHERINE, additional

Published
2022
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