43 results on '"Dokurno, Pawel"'
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2. The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its Analogues
3. Design and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate
4. Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B
5. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
6. A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinaseElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00439b
7. Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors
8. Crystal structure of the M‐fragment of α‐catenin: implications for modulation of cell adhesion
9. Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor
10. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
11. Theoretical studies on the structure, thermochemistry, vibrational spectroscopy, and other features of HfX(sub 6)(super 2-) (X = F, Cl, Br, I). Electrostatic energy in hexahalogenohafnates
12. Abstract 4482: S64315 (MIK665) is a potent and selective Mcl1 inhibitor with strong antitumor activity across a diverse range of hematologic tumor models
13. Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity
14. Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
15. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth
16. Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)
17. Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)
18. Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution
19. Structure-guided design of α-amino acid-derived Pin1 inhibitors
20. Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas
21. Abstract 2782: Bcl-2 selective antagonists show antitumor activity without dose limiting platelet toxicity
22. Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity
23. Corrigendum to “Structure-guided design of α-amino acid-derived Pin1 inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 586]
24. ChemInform Abstract: Synthesis, X-Ray Structure and High-Resolution NMR Spectroscopy of Methyl 3-Azido-2,3-dideoxy-α-D-arabino-hexopyranoside (XI).
25. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
26. Abstract A212: A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor‐induced apoptosis in HCT116 colon carcinoma cells
27. Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design
28. Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping
29. Molecular Basis of AKAP Specificity for PKA Regulatory Subunits
30. Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: Protein structure-guided design and SAR
31. Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2
32. Structure of the AAA ATPase p97
33. Crystal structure at 1.95 å resolution of the breast tumour-specific antibody SM3 complexed with its peptide epitope reveals novel hypervariable loop recognition
34. Conformational analysis of the first observed non-proline cis-peptide bond occurring within the complementarity determining region (CDR) of an antibody
35. X-Ray, Quantum Mechanics and Density Functional Methods in the Examination of Structure and Tautomerism of N-Methyl-Substituted Acridin-9-amine Derivatives
36. Theoretical Studies on the Structure, Thermochemistry, Vibrational Spectroscopy, and Other Features of HfX62- (X = F, Cl, Br, I). Electrostatic Energy in Hexahalogenohafnates
37. Theoretical Studies on the Geometry, Thermochemistry, Vibrational Spectroscopy, and Charge Distribution in TiX62- (X = F, Cl, Br, I). Coulombic Energy in hexahalogenotitanate Lattices
38. Theoretical studies on structure, thermochemistry, vibrational spectroscopy, and other features of ZrX2−6 (X=F,Cl,Br,I): Coulombic energy in inorganic and organic hexahalogenozirconates
39. Electrostatic energy in inorganic and organic hexahalogenoplatinate lattices
40. Thermal properties, thermolysis and thermochemistry of alkanaminium iodides
41. Crystal structure of the M-fragment of a-catenin: implications for modulation of cell adhesion.
42. ChemInform Abstract: Synthesis, X-Ray Structure and High-Resolution NMR Spectroscopy of Methyl 3-Azido-2,3-dideoxy-α-D-arabino-hexopyranoside (XI).
43. Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
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