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9 results on '"Dokoumetzidis, Aris"'

1. Modeling and administration scheduling of fractional-order pharmacokinetic systems

Author

Herceg, Domagoj, Ntouskas, Sotiris, Sopasakis, Pantelis, Dokoumetzidis, Aris, Macheras, Panos, Sarimveis, Haralambos, and Patrinos, Panagiotis

Subjects
Mathematics - Dynamical Systems, Mathematics - Optimization and Control
Abstract

Fractional-order dynamical systems were recently introduced in the field of pharmacokinetics where they proved powerful tools for modeling the absorption, disposition, distribution and excretion of drugs which are liable to anomalous diffusion, deep tissue trapping and other nonlinear phenomena. In this paper we present several ways to simulate such fractional-order pharmacokinetic models and we evaluate their accuracy and complexity on a fractional-order pharmacokinetic model of Amiodarone, an anti-arrhythmic drug. We then propose an optimal administration scheduling scheme and evaluate it on a population of patients.

Published
2017

3. Fractional Pharmacokinetics

Author

Dokoumetzidis, Aris, Antman, S.S, Editor-in-chief, Greengard, L., Editor-in-chief, Holmes, P.J., Editor-in-chief, Durrett, R., Series editor, Glass, L., Series editor, Goriely, Alain, Series editor, Kohn, R., Series editor, Krishnaprasad, P. S., Series editor, Murray, J.D., Series editor, Peskin, C., Series editor, Sastry, S.S., Series editor, Sneyd, J., Series editor, Macheras, Panos, and Iliadis, Athanassios

Published
2016
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5. Comparative pharmacokinetics of the three echinocandins in ICU patients

Author

Mainas, Efstratios, primary, Apostolopoulou, Olympia, additional, Siopi, Maria, additional, Apostolidi, Styliani, additional, Neroutsos, Efthymios, additional, Mirfendereski, Helene, additional, Marchand, Sandrine, additional, Couet, William, additional, Dokoumetzidis, Aris, additional, Valsami, Georgia, additional, Sambatakou, Helen, additional, Dimopoulos, George, additional, and Meletiadis, Joseph, additional

Published
2020
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6. Modeling and administration scheduling of fractional-order pharmacokinetic systems

Author

Herceg, Domagoj Ntouskas, Sotiris Sopasakis, Pantelis and Dokoumetzidis, Aris Macheras, Panos Sarimveis, Haralambos and Patrinos, Panagiotis

Abstract

Fractional-order dynamical systems were recently introduced in the field of pharmacokinetics where they proved powerful tools for modeling the absorption, disposition, distribution and excretion of drugs which are liable to anomalous diffusion, deep tissue trapping and other nonlinear phenomena. In this paper we present several ways to simulate such fractional order pharmacokinetic models and we evaluate their accuracy and complexity on a fractional order pharmacokinetic model of Amiodarone, an anti-arrhythmic drug. We then propose an optimal administration scheduling scheme and evaluate it on a population of patients. (C) 2017, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

Published
2017

8. Modeling and administration scheduling of fractional-order pharmacokinetic systems**The work of the last author was supported by the KU Leuven Research Council under BOF/STG-15-043.

Author

Herceg, Domagoj, Ntouskas, Sotiris, Sopasakis, Pantelis, Dokoumetzidis, Aris, Macheras, Panos, Sarimveis, Haralambos, and Patrinos, Panagiotis

Abstract

Fractional-order dynamical systems were recently introduced in the field of pharmacokinetics where they proved powerful tools for modeling the absorption, disposition, distribution and excretion of drugs which are liable to anomalous diffusion, deep tissue trapping and other nonlinear phenomena. In this paper we present several ways to simulate such fractional-order pharmacokinetic models and we evaluate their accuracy and complexity on a fractional-order pharmacokinetic model of Amiodarone, an anti-arrhythmic drug. We then propose an optimal administration scheduling scheme and evaluate it on a population of patients.

Published
2017
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9. Commentary on the MID3 Good Practices Paper.

Author

Manolis, Efthymios, Brogren, Jacob, Cole, Susan, Hay, Justin L., Nordmark, Anna, Karlsson, Kristin E., Lentz, Frederike, Benda, Norbert, Wangorsch, Gaby, Pons, Gerard, Zhao, Wei, Gigante, Valeria, Serone, Francesca, Standing, Joseph F., Dokoumetzidis, Aris, Vakkilainen, Juha, van den Heuvel, Michiel, Mangas Sanjuan, Victor, Taminiau, Johannes, and Kerwash, Essam

Subjects
DRUG development, MEDICAL practice, SIMULATION methods & models
Abstract

During the last 10 years the European Medicines Agency (EMA) organized a number of workshops on modeling and simulation, working towards greater integration of modeling and simulation (M&S) in the development and regulatory assessment of medicines. In the 2011 EMA - European Federation of Pharmaceutical Industries and Associations (EFPIA) Workshop on Modelling and Simulation, European regulators agreed to the necessity to build expertise to be able to review M&S data provided by companies in their dossier. This led to the establishment of the EMA Modelling and Simulation Working Group (MSWG). Also, there was agreement reached on the need for harmonization on good M&S practices and for continuing dialog across all parties. The MSWG acknowledges the initiative of the EFPIA Model-Informed Drug Discovery and Development (MID3) group in promoting greater consistency in practice, application, and documentation of M&S and considers the paper is an important contribution towards achieving this objective. [ABSTRACT FROM AUTHOR]

Published
2017
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